MedWorm provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest medical blog items that have been tagged with 'adverse drug reactions'. Sat, 03 Sep 2011 02:47:55 +0100 http://www.medworm.com/index.php?rid=4214185&cid=t_97449_109_f&fid=34504&url=http%3A%2F%2Fwww.blacktriangle.org%2Fblog%2F%3Fp%3D2163 The safety of newly marketed drugs is always provisional, based on the relatively limited population the drugs are used in prior to marketing. The number of subjects who take a drug in clinical trials is large enough to detect efficacy, but too small to detect rare, but serious, adverse events. In addition, the patients are [...] (Source: Black Triangle) Black Triangle blogs http://www.medworm.com/rss/comments.php?id=4214185 Tue, 30 Nov 2010 09:43:21 +0100 4214185 http://www.medworm.com/index.php?rid=4022951&cid=t_97449_109_f&fid=34504&url=http%3A%2F%2Fwww.blacktriangle.org%2Fblog%2F%3Fp%3D2130 Just a short note. A couple of years ago there was a great deal of fuss about paracetamol and a possible link with asthma in children [Lancet]. The study reported on was a large retrospective study (205 487 children) involving surveying parents about their children’s previous paracetamol use and symptoms of asthma. There is an [...] (Source: Black Triangle) Black Triangle blogs http://www.medworm.com/rss/comments.php?id=4022951 Fri, 01 Oct 2010 15:39:20 +0100 4022951 http://www.medworm.com/index.php?rid=3934499&cid=t_97449_109_f&fid=34504&url=http%3A%2F%2Fwww.blacktriangle.org%2Fblog%2F%3Fp%3D2102 (Source: Black Triangle) Black Triangle blogs http://www.medworm.com/rss/comments.php?id=3934499 Sat, 04 Sep 2010 10:24:50 +0100 3934499 http://www.medworm.com/index.php?rid=2865723&cid=t_97449_109_f&fid=34504&url=http%3A%2F%2Fwww.blacktriangle.org%2Fblog%2F%3Fp%3D2029 I’m presenting a couple of posters at the International Society of Pharmacovigilance Conference this week. One is concerned with possible neuropsychiatric reactions to varenicline, and the other uses the DoTS ADR classification system to analyse reports of angioedema with angiotensin-II receptor antagonists. Further details at the links in the text. (Source: Black Triangle) Black Triangle blogs http://www.medworm.com/rss/comments.php?id=2865723 Tue, 06 Oct 2009 10:24:22 +0100 2865723 http://www.medworm.com/index.php?rid=2688738&cid=t_97449_109_f&fid=34504&url=http%3A%2F%2Fwww.blacktriangle.org%2Fblog%2F%3Fp%3D2010 many of those prescribed Tamiflu are stockpiling it to be sure of having access to the powerful drug Independent 10th of August Doctors should stop giving Tamiflu to children as a routine treatment for swine flu, researchers concluded after finding the drug can cause more harm than good. Independent 11th of August To be fair, no wonder people are [...] (Source: Black Triangle) Black Triangle blogs http://www.medworm.com/rss/comments.php?id=2688738 Tue, 11 Aug 2009 07:30:10 +0100 2688738 http://www.medworm.com/index.php?rid=2441789&cid=t_97449_109_f&fid=34504&url=http%3A%2F%2Fwww.blacktriangle.org%2Fblog%2F%3Fp%3D1973 I have a new article in The Pharmaceutical Journal published with a colleague Dr Deborah Layton looking at the neuraminidase inhibitors oseltamivir and zanamivir. Cox A, Layton D. Adverse drug reactions: Neuraminidase inhibitors: widespread use for influenza may reveal more adverse effects. The Pharmaceutical Journal 2009; 282:621-622 The neuraminidase inhibitors (NAIs), oseltamivir (Tamiflu) and zanamivir (Relenza), are [...] (Source: Black Triangle) Black Triangle blogs http://www.medworm.com/rss/comments.php?id=2441789 Fri, 22 May 2009 18:22:28 +0100 2441789 http://www.medworm.com/index.php?rid=2405463&cid=t_97449_109_f&fid=34504&url=http%3A%2F%2Fwww.blacktriangle.org%2Fblog%2F%3Fp%3D1963 The Guardian has an interesting piece on Orwell and the writing of 1984. The information about the treatment of Orwell’s tuberculosis (TB) seems to indicate that he suffered a fairly severe skin hypersensivity reaction to streptomycin. “In 1947 there was no cure for TB - doctors prescribed fresh air and a regular diet - but there [...] (Source: Black Triangle) Black Triangle blogs http://www.medworm.com/rss/comments.php?id=2405463 Sun, 10 May 2009 23:38:52 +0100 2405463 http://www.medworm.com/index.php?rid=2313667&cid=t_97449_109_f&fid=34504&url=http%3A%2F%2Fwww.blacktriangle.org%2Fblog%2F%3Fp%3D1944 On Friday 17th April 2009 you could attend a one day course at Aston University on drug metabolism. Drug metabolism exerts a powerful influence on drug action - from complete failure of a drug’s effectiveness to life-threatening toxicity. This course focuses on the aims, responses and processes of human drug biotransformation systems. As a result, it [...] (Source: Black Triangle) Black Triangle blogs http://www.medworm.com/rss/comments.php?id=2313667 Mon, 06 Apr 2009 17:12:14 +0100 2313667 http://www.medworm.com/index.php?rid=2182288&cid=t_97449_109_f&fid=34504&url=http%3A%2F%2Fwww.blacktriangle.org%2Fblog%2F%3Fp%3D1901 An important study in the UK looks at the occurance of adverse drug reactions in hospital in-inpatients. It’s a six month study of in-patients at a Liverpool hospital, and can be considered a follow-up on the study on ADRs seen at admission in the BMJ. Over six months, there were a total of 3695 patient episodes [...] (Source: Black Triangle) Black Triangle blogs http://www.medworm.com/rss/comments.php?id=2182288 Thu, 12 Feb 2009 01:44:37 +0100 2182288 http://www.medworm.com/index.php?rid=2147458&cid=t_97449_109_f&fid=34504&url=http%3A%2F%2Fwww.blacktriangle.org%2Fblog%2F%3Fp%3D1890 Here’s an interesting report of a series of vaccine reactions: A group of schoolchildren in Luton were taken to hospital after complaining that they felt unwell following an injection this morning (January 30). Seven students from Year 10 at Icknield High School were taken to the Luton & Dunstable Hospital as they became ill immediately after receiving [...] (Source: Black Triangle) Black Triangle blogs http://www.medworm.com/rss/comments.php?id=2147458 Fri, 30 Jan 2009 22:05:58 +0100 2147458 http://www.medworm.com/index.php?rid=2094665&cid=t_97449_109_f&fid=34504&url=http%3A%2F%2Fwww.blacktriangle.org%2Fblog%2F%3Fp%3D1869 Deborah Layton and I have a brief article in The Pharmaceutical Journal this week on the subject of antispychotics and the evidence for the risk of stroke associated with their use. Layton D, Cox A. Antipsychotics and stroke: the story to date. The Pharmaceutical Journal 2009; 282: 30 You have to register to read it. (Source: Black Triangle) Black Triangle blogs http://www.medworm.com/rss/comments.php?id=2094665 Sat, 10 Jan 2009 10:06:03 +0100 2094665 http://www.medworm.com/index.php?rid=2094666&cid=t_97449_109_f&fid=34504&url=http%3A%2F%2Fwww.blacktriangle.org%2Fblog%2F%3Fp%3D1868 Cox A. Involving patients in reporting adverse drug reactions should be welcomed. The Pharmaceutical Journal 2009; 282: 16-17 Patients are no longer the passive recipients of drug therapy instigated by medical professionals. There is increasing patient engagement in individual decisions about their own drug therapy, public discussions about the provision of high cost drugs in the [...] (Source: Black Triangle) Black Triangle blogs http://www.medworm.com/rss/comments.php?id=2094666 Sat, 10 Jan 2009 09:57:50 +0100 2094666 http://www.medworm.com/index.php?rid=1901190&cid=t_97449_109_f&fid=34504&url=http%3A%2F%2Fwww.blacktriangle.org%2Fblog%2F%3Fp%3D1852 The EMEA’s Committee for Medicinal Products for Human Use (CHMP) have pulled the marketing authorisation for rimonabant (Acomplia) [PDF]. This isn’t much of a surprise. What is interesting in this case is the reasoning, which not only addresses safety concerns, but also concerns about effectiveness in clinical practice (as opposed to clinical trials). Effectiveness, rather [...] (Source: Black Triangle) Black Triangle blogs http://www.medworm.com/rss/comments.php?id=1901190 Thu, 23 Oct 2008 21:06:21 +0100 1901190 http://www.medworm.com/index.php?rid=1802560&cid=t_97449_109_f&fid=34504&url=http%3A%2F%2Fwww.blacktriangle.org%2Fblog%2F%3Fp%3D1838 In times gone by regulatory bodies concerned with drugs were a black box. Decisions were made and conveyed to the public, with little explanation. Other concerns, that were preliminary and yet to be confirmed by further evidence might be delayed. Public engagement with regulators was minimal. For a number of years things have been changing. The [...] (Source: Black Triangle) Black Triangle blogs http://www.medworm.com/rss/comments.php?id=1802560 Thu, 18 Sep 2008 08:51:46 +0100 1802560 http://www.medworm.com/index.php?rid=1802561&cid=t_97449_109_f&fid=34504&url=http%3A%2F%2Fwww.blacktriangle.org%2Fblog%2F%3Fp%3D1842 Capitalism kills. There is no better example of that principle than in China. The most recent example in the news tonight is that of contaminated baby milk. China says it will launch nationwide testing of all dairy products following the deaths of three babies from contaminated milk formula. More than 6,200 babies have fallen ill after drinking [...] (Source: Black Triangle) Black Triangle blogs http://www.medworm.com/rss/comments.php?id=1802561 Wed, 17 Sep 2008 23:13:30 +0100 1802561 http://www.medworm.com/index.php?rid=1729290&cid=t_97449_109_f&fid=34504&url=http%3A%2F%2Fwww.blacktriangle.org%2Fblog%2F%3Fp%3D1827 There is an excellent paper at the Archives of Internal Medicine describing a seeding trial. The authors of the paper helpfully provide a useful and concise description of a such a trial: Seeding trials are clinical trials designed by pharmaceutical companies to promote the use of pharmacotherapies that were recently approved or are under review by [...] (Source: Black Triangle) Black Triangle blogs http://www.medworm.com/rss/comments.php?id=1729290 Sat, 23 Aug 2008 21:53:10 +0100 1729290 http://www.medworm.com/index.php?rid=1729291&cid=t_97449_109_f&fid=34504&url=http%3A%2F%2Fwww.blacktriangle.org%2Fblog%2F%3Fp%3D1826 Apologies for the lack of posting here in August. I’ve been traveling for reasons of both business and pleasure. Here are a couple of recent non-blog related items I have written. Cox AR, Wood KMG, Marriott JF, Ferner RE. Causality and definitions: How general practitioners decide what to report to spontaneous reporting schemes. Pharmacoepidemiology and [...] (Source: Black Triangle) Black Triangle blogs http://www.medworm.com/rss/comments.php?id=1729291 Sat, 23 Aug 2008 20:39:09 +0100 1729291 http://www.medworm.com/index.php?rid=1683440&cid=t_97449_150_f&fid=35777&url=http%3A%2F%2Ffeeds.feedburner.com%2F%7Er%2FPharmalot%2F%7E3%2F356571056%2F Seems simple, yes? And so a group of Duke University researchers developed a hypothetical model to estimate the expected incremental number of adverse drug events that could be avoided once a drug is widely available. The upshot: “Requiring larger preapproval databases could be a cost-effective means of reducing adverse events in post-approval populations,” they write in Health Affairs. As you may recall, most industry-sponsored clinical trials of new drugs are designed to determine efficacy in order to gain regulatory approval. But the researchers note that detecting adverse drug events is “rarely considered when sample-size calculations are undertaken for clinical trials.” Thus, the statistical power to find side effects is “inherently a by-product” of... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=1683440 Tue, 05 Aug 2008 17:39:31 +0100 1683440 http://www.medworm.com/index.php?rid=1645733&cid=t_97449_109_f&fid=34504&url=http%3A%2F%2Fwww.blacktriangle.org%2Fblog%2F%3Fp%3D1821 Adverse drug reactions (ADRs) are a massive burden on the NHS, and a significant cause of morbidity and mortality. When I worked on a cardiology ward, one of the more serious ADRs that occurred was severe haemorrhage associated with streptokinase. Rather than dying of a heart attack, the drug we gave to patients to improve [...] (Source: Black Triangle) Black Triangle blogs http://www.medworm.com/rss/comments.php?id=1645733 Wed, 23 Jul 2008 06:39:41 +0100 1645733 http://www.medworm.com/index.php?rid=1436718&cid=t_97449_109_f&fid=34504&url=http%3A%2F%2Fwww.blacktriangle.org%2F%2Fwordpress%2Fwp-content%2Famericancliche.mp3 Just testing Podpress. Risk-benefit discussion from American Cliche. (Source: Black Triangle) Black Triangle blogs http://www.medworm.com/rss/comments.php?id=1436718 Mon, 12 May 2008 09:43:21 +0100 1436718 http://www.medworm.com/index.php?rid=1388837&cid=t_97449_109_f&fid=34504&url=http%3A%2F%2Fwww.blacktriangle.org%2Fblog%2F%3Fp%3D1773 Because all medicines have the potential to cause adverse effects, the safety of prescribed medicines is a central concern for health professionals. The initial decision to resort to pharmacological treatment, the choice of drug, and the management and monitoring of the patient require knowledge of drug-induced disease. Additionally, a wider public health duty exists for [...] (Source: Black Triangle) Black Triangle blogs http://www.medworm.com/rss/comments.php?id=1388837 Mon, 21 Apr 2008 08:53:48 +0100 1388837 http://www.medworm.com/index.php?rid=1369635&cid=t_97449_109_f&fid=34504&url=http%3A%2F%2Fwww.blacktriangle.org%2Fblog%2F%3Fp%3D1762 Y Lliwedd, taken on the way down as the clouds lifted. On Friday I made a quick ascent of Snowdon from Pen-y-Pass using the easy Miners track, before a conference at Bangor University. I had the choice of mountain biking in the rain, or walking in snow about 550m. The second seemed the drier option, so [...] (Source: Black Triangle) Black Triangle blogs http://www.medworm.com/rss/comments.php?id=1369635 Sun, 13 Apr 2008 22:07:07 +0100 1369635 http://www.medworm.com/index.php?rid=1362344&cid=t_97449_109_f&fid=34504&url=http%3A%2F%2Fwww.blacktriangle.org%2Fblog%2F%3Fp%3D1759 The past few weeks have had a few interesting papers published on the subject of medicines and children. Children are often ill-served by medication, partly due to the difficulties associated with medication use in children and running clinical trials, and partly because of pharmaceutical companies lack of interest in obtaining paediatric licences for a small [...] (Source: Black Triangle) Black Triangle blogs http://www.medworm.com/rss/comments.php?id=1362344 Wed, 09 Apr 2008 23:30:07 +0100 1362344 http://www.medworm.com/index.php?rid=1327411&cid=t_97449_109_f&fid=34504&url=http%3A%2F%2Fwww.blacktriangle.org%2Fblog%2F%3Fp%3D1747 So what happens when you report a suspected adverse drug reaction to a scheme like the UK’s Yellow Card scheme or the US Medwatch scheme? Although individual reports are examined, large amounts of data can be used to look for drug safety signals. Such signals are a sign that an adverse effect may be associated [...] (Source: Black Triangle) Black Triangle blogs http://www.medworm.com/rss/comments.php?id=1327411 Wed, 26 Mar 2008 00:48:33 +0100 1327411 http://www.medworm.com/index.php?rid=1311465&cid=t_97449_150_f&fid=35777&url=http%3A%2F%2Ffeeds.feedburner.com%2F%7Er%2FPharmalot%2F%7E3%2F253758249%2F More than 3 percent of all deaths seem to be caused by adverse reactions to medical drugs, according to new research, according to a report in Nature. If substantiated by further work, this would make fatal adverse drug reactions the 7th most common cause of death in Sweden, where the research was done. James Ritter, the editor-in-chief of the British Journal of Clinical Pharmacology, which published the research, calls the finding “striking.” “It is a surprisingly high figure,” Donald Singer, a pharmacology expert at the University of Warwick, tells Nature, while wondering if the results can easily be generalized to other areas. Adverse drug reactions are known to be responsible for between 3 percent and 12 percent of hospital admissions, and fatal drug reactions account f... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=1311465 Tue, 18 Mar 2008 17:26:32 +0100 1311465 http://www.medworm.com/index.php?rid=1241728&cid=t_97449_109_f&fid=34504&url=http%3A%2F%2Fwww.blacktriangle.org%2Fblog%2F%3Fp%3D1722 There are plenty of instances of similar sounding drug names causing confusion and adverse events in patients, but this is the first time I’ve seen a similar sounding pharmaceutical factory causing adverse drug reactions. The Chinese facility that supplies the active ingredient of the widely used blood thinner heparin was never inspected by the Food and [...] (Source: Black Triangle) Black Triangle blogs http://www.medworm.com/rss/comments.php?id=1241728 Tue, 19 Feb 2008 16:36:01 +0100 1241728 http://www.medworm.com/index.php?rid=1223612&cid=t_97449_109_f&fid=34504&url=http%3A%2F%2Fwww.blacktriangle.org%2Fblog%2F%3Fp%3D1719 I’m quoted in this article at The Pharmaceutical Journal in relation to general practitioner reporting. “It is really important that we don’t lose the bedrock of GPs because they have the most intense relationships with patients,” said Anthony Cox, a pharmacovigilance pharmacist for the West Midlands Centre for Adverse Drug Reactions. “There has been a slight dip [...] (Source: Black Triangle) Black Triangle blogs http://www.medworm.com/rss/comments.php?id=1223612 Mon, 11 Feb 2008 23:10:11 +0100 1223612 http://www.medworm.com/index.php?rid=1216444&cid=t_97449_109_f&fid=34504&url=http%3A%2F%2Fwww.blacktriangle.org%2Fblog%2F%3Fp%3D1717 I am quoted in tomorrow’s BMJ in an article entitled Most doctors still don’t report adverse reactions to drugs. My comments were made at the Medicines and Healthcare Products Regulatory Agency conference in Birmingham this Monday. Anthony Cox, a pharmacist at the West Midlands Centre for Adverse Drug Reactions, studied what motivates a GP to report [...] (Source: Black Triangle) Black Triangle blogs http://www.medworm.com/rss/comments.php?id=1216444 Thu, 07 Feb 2008 23:53:49 +0100 1216444 http://www.medworm.com/index.php?rid=1153926&cid=t_97449_109_f&fid=34504&url=http%3A%2F%2Fwww.blacktriangle.org%2Fblog%2F%3Fp%3D1699 There are still places available at the MHRA conference, Risk Management of Medicines in EU: Current Experience - Future Direction, on the 4th of February. I’ll be speaking about my qualitative research into the motivating factors which influence general practitioners’ decisions to report adverse drug reactions to the Yellow Card scheme. (Source: Black Triangle) Black Triangle blogs http://www.medworm.com/rss/comments.php?id=1153926 Tue, 15 Jan 2008 23:03:51 +0100 1153926 http://www.medworm.com/index.php?rid=1103376&cid=t_97449_109_f&fid=34504&url=http%3A%2F%2Fwww.blacktriangle.org%2Fblog%2F%3Fp%3D1691 Craig Brown writes: A reader of my parodic A-Z of Eth!cal PR column by Su Barking has kindly sent in a cutting from the magazine PR Week, dated November 9, 2007. “Clew Communications is to provide PR support for the relaunch of the controversial drug Thalidomide,” it reads. A photograph of the MD of Clew Communications, Mary Hicks, [...] (Source: Black Triangle) Black Triangle blogs http://www.medworm.com/rss/comments.php?id=1103376 Tue, 18 Dec 2007 14:52:55 +0100 1103376 http://www.medworm.com/index.php?rid=1039976&cid=t_97449_109_f&fid=34504&url=http%3A%2F%2Fwww.blacktriangle.org%2Fblog%2F%3Fp%3D1672 Lots of interesting things happening. The withdrawal of lumiracoxib is covered at adr.org.uk, as are the serious skin reactions to strontium ranelate. The NPC cover recent changes to rosiglitazone’s licence brought in by the FDA, and the psychiatric effects of rimonabant. (Source: Black Triangle) Black Triangle blogs http://www.medworm.com/rss/comments.php?id=1039976 Tue, 20 Nov 2007 23:29:18 +0100 1039976 http://www.medworm.com/index.php?rid=945279&cid=t_97449_109_f&fid=34504&url=http%3A%2F%2Fwww.blacktriangle.org%2Fblog%2F%3Fp%3D1654 It was the thalidomide disaster that first captured public attention about the risks associated with drugs and ensured that major regulatory changes in drug safety would occur throughout the world, including the UK. Paradoxically, thalidomide was initially introduced and marketed to address a serious safety concern. In the 1950s barbiturates were in widespread use. However, [...] (Source: Black Triangle) Black Triangle blogs http://www.medworm.com/rss/comments.php?id=945279 Fri, 12 Oct 2007 08:51:16 +0100 945279 http://www.medworm.com/index.php?rid=882343&cid=t_97449_109_f&fid=34504&url=http%3A%2F%2Fwww.blacktriangle.org%2Fblog%2F%3Fp%3D1647 Here’s a piece of history, I believe this is the first drug safety signal detected by the Yellow Card scheme published in the BMJ in 1964. Cahal, DA. Jaundice and Cardivix. British Medical Journal 1964; 2(5413): 882 (Source: Black Triangle) Black Triangle blogs http://www.medworm.com/rss/comments.php?id=882343 Tue, 18 Sep 2007 21:03:45 +0100 882343 http://www.medworm.com/index.php?rid=682039&cid=t_97449_109_f&fid=34504&url=http%3A%2F%2Fwww.blacktriangle.org%2Fblog%2F%3Fp%3D1596 In the wake of the concerns about rosiglitazone and cardiovascular events, a response at the BMJ arguing that spontaneous reporting is still of importance. (Source: Black Triangle) Black Triangle blogs http://www.medworm.com/rss/comments.php?id=682039 Wed, 20 Jun 2007 13:40:04 +0100 682039 http://www.medworm.com/index.php?rid=682040&cid=t_97449_109_f&fid=34504&url=http%3A%2F%2Fwww.blacktriangle.org%2Fblog%2F%3Fp%3D1595 I have just received copies of my paper published in the Italian Adverse Drug Reaction Bulletin: Cox AR, Gilmartin B. Reazioni indesiderate oculari indotte da farmaci. Adverse Drug Reaction Bulletin 2007; 174: 697-700 (Source: Black Triangle) Black Triangle blogs http://www.medworm.com/rss/comments.php?id=682040 Tue, 19 Jun 2007 12:22:11 +0100 682040 http://www.medworm.com/index.php?rid=673820&cid=t_97449_109_f&fid=34504&url=http%3A%2F%2Fwww.blacktriangle.org%2Fblog%2F%3Fp%3D1590 Here’s a reminder that one should read instructions and treat all medicines, including non-prescription ones, with respect. A 17-year-old athlete has died folllowing excessive use of an over-the-counter topical anti-inflammatory sports rub: Arielle Newman, a cross-country runner at Notre Dame Academy on Staten Island, died after her body absorbed high levels of methyl salicylate, an anti-inflammatory [...] (Source: Black Triangle) Black Triangle blogs http://www.medworm.com/rss/comments.php?id=673820 Mon, 11 Jun 2007 12:32:31 +0100 673820 http://www.medworm.com/index.php?rid=658448&cid=t_97449_109_f&fid=34504&url=http%3A%2F%2Fwww.blacktriangle.org%2Fblog%2F%3Fp%3D1589 Recent MHRA Drug Safety news. (Source: Black Triangle) Black Triangle blogs http://www.medworm.com/rss/comments.php?id=658448 Tue, 05 Jun 2007 20:35:36 +0100 658448 http://www.medworm.com/index.php?rid=622783&cid=t_97449_109_f&fid=34504&url=http%3A%2F%2Fwww.blacktriangle.org%2Fblog%2F%3Fp%3D1585 As a counterpoint to the post about the mouse, it is worth remembering that sometimes suspicions of harm can be true. Here are thirteen facts about thalidomide, some of which you might not have known. Chemie Grünenthal, who developed thalidomide (Contergan in Germany, Distaval in the UK), had two drugs pulled from the market prior to [...] (Source: Black Triangle) Black Triangle blogs http://www.medworm.com/rss/comments.php?id=622783 Sat, 19 May 2007 22:58:04 +0100 622783 http://www.medworm.com/index.php?rid=610742&cid=t_97449_109_f&fid=34504&url=http%3A%2F%2Fwww.blacktriangle.org%2Fblog%2F%3Fp%3D1582 I’m currently sat in the British Library sifting my way though various tomes concerned with adverse drug reactions, and have come across the following interesting poem about causation by W.R. Espy, buried within a discussion about detection of adverse events: A mouse of my acquaintance in seven days was fed Twice twenty thousand swordfish, and now that [...] (Source: Black Triangle) Black Triangle blogs http://www.medworm.com/rss/comments.php?id=610742 Wed, 16 May 2007 14:33:29 +0100 610742 http://www.medworm.com/index.php?rid=517223&cid=t_97449_109_f&fid=34504&url=http%3A%2F%2Fwww.blacktriangle.org%2Fblog%2F%3Fp%3D1570 “the number of new preparations or new formulations of previously available drugs introduced each year is enormous. Many of these have little virtue and some are stupid or useless mixtures of drugs which add little to modern medicine except expense and unnecessarily increase the number of chemicals a human being is asked to take. Their [...] (Source: Black Triangle) Black Triangle blogs http://www.medworm.com/rss/comments.php?id=517223 Mon, 02 Apr 2007 19:42:58 +0100 517223 http://www.medworm.com/index.php?rid=486919&cid=t_97449_132_f&fid=35011&url=http%3A%2F%2Ffeeds.feedburner.com%2F%7Er%2Fmndoci%2F%7E3%2F102643126%2F A new medicinal chemistry blog has an interesting post about “idiosyncratic” drug reactions, adverse reactions that occur in a small set of patients. For any number of reasons, trying to get a handle on unpredictable ADRs in small patient subpopulations is critical for the pharmaceutical industry. I am no authority on such ADRs and suggest reading the original post for more information, including references and the authors views. Currently, idiosyncratic ADRs are not predictable since their mechanisms are not well understood. This is where I believe that translational research is going to play a strong role. Can we identify potential biomarkers (either metabolic markers or genotypes or anything else) that can help identify potential patient subpopulations that might suffer from... business|bytes|genes|molecules blogs http://www.medworm.com/rss/comments.php?id=486919 Sun, 18 Mar 2007 20:06:20 +0100 486919 http://www.medworm.com/index.php?rid=425056&cid=t_97449_109_f&fid=34504&url=http%3A%2F%2Fwww.blacktriangle.org%2Fblog%2F%3Fp%3D1568 Here’s a copy of my article Recognition and management of drug-induced blood disorders that was published on the 5th of February 2007 in Prescriber. Obviously, given the massive subject this is, a short article of this nature does not address the detailed management of blood dyscrasias, but I hope it alerts people to the possibility [...] (Source: Black Triangle) Black Triangle blogs http://www.medworm.com/rss/comments.php?id=425056 Mon, 19 Feb 2007 20:56:44 +0100 425056 http://www.medworm.com/index.php?rid=409427&cid=t_97449_109_f&fid=34504&url=http%3A%2F%2Fwww.blacktriangle.org%2Fblog%2F%3Fp%3D1555 Any comments about the vet, involved in the H5N1 virus clear-up, admitted to hospital with what is described as mild non-specific symptoms, or a mild respiratory illness are pure speculation. The government are arguing that H4N1 infection is unlikely because of the precautionary measures taken - which makes sense. One of those precautionary measures is the [...] (Source: Black Triangle) Black Triangle blogs http://www.medworm.com/rss/comments.php?id=409427 Wed, 07 Feb 2007 07:30:57 +0100 409427