MedWorm provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest medical blog items that have been tagged with 'agonist'. Sat, 03 Sep 2011 02:46:28 +0100 http://www.medworm.com/index.php?rid=5159257&cid=t_437924_112_f&fid=34971&url=http%3A%2F%2Fblog.drmalpani.com%2F2011%2F08%2Fhow-antagon-and-other-gnrh-anatgonists.html In the past, most in-vitro fertilization (IVF) centres used pituitary down-regulation with gonadotrophin-releasing hormone (GnRH) agonists to prevent a premature LH surge and premature ovulation and luteinization. However, this required at least 7–14 days of GnRH agonist pretreatment. This is why researchers developed molecules which would cause an immediate blockage of the GnRH receptors on the pituitary gland, to stop the pituitary from producing gonadotropins instantly . This was felt to be a more rational approach , as these would induce instant downregulation , and prevent a spontaneous LH surge more effectively . Brand names of the GnRH antagonists include Antagon and Cetroride. Thus , treatment with the antagonist can be limited to only those 4-6 days when high oestradiol levels... The Patient's Doctor blogs http://www.medworm.com/rss/comments.php?id=5159257 Wed, 24 Aug 2011 04:41:00 +0100 5159257 http://www.medworm.com/index.php?rid=4622509&cid=t_437924_151_f&fid=36896&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FSuboxoneTalkZone%2F%7E3%2FJUCM1S6JwUs%2F I recently resumed writing for the expert forum on addiction at MedHelp.Org. One result of writing for MedHelp is that I receive a number of e-mails from people with questions about specific issues related to buprenorphine. The most common questions are from people on buprenorphine undergoing surgery, asking about the safety of anesthesia and about postoperative pain control. There are very significant problems with medical coverage for patients on buprenorphine undergoing surgery. Patients on buprenorphine will occasionally need surgery, and in such cases there are often no doctors willing and/or competent to manage postoperative pain. Psychiatrists, frankly, have little knowledge or experience in this area. Before psychiatry residency, medical school graduates generally complete a medica... Suboxone Talk Zone blogs http://www.medworm.com/rss/comments.php?id=4622509 Wed, 23 Mar 2011 01:35:08 +0100 4622509 http://www.medworm.com/index.php?rid=4302290&cid=t_437924_151_f&fid=36896&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FSuboxoneTalkZone%2F%7E3%2Fw04RB3n_ILQ%2F I often receive e-mails asking for advice on tapering Suboxone, or asking how long Suboxone withdrawal should last.  People who read my blog know my approach to stopping Suboxone; I see it as an exercise in futility even in the rare cases where the person is successful, because of a relapse rate that verges on 100%. A couple myths to get out of the way… there is NO evidence that withdrawal becomes more difficult the longer a person is on buprenorphine.  In fact, from my experience the opposite is true.  The feelings and emotions during withdrawal are aggravated by the guilt and shame of active using, and the further from active using a person gets, the less the suffering during withdrawal—and the better able the person is to keep some perspective on what is happening, rather than dr... Suboxone Talk Zone blogs http://www.medworm.com/rss/comments.php?id=4302290 Fri, 31 Dec 2010 23:33:38 +0100 4302290 http://www.medworm.com/index.php?rid=4179523&cid=t_437924_150_f&fid=35777&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FPharmalot%2F%7E3%2FggN0pc0DhfA%2F Less than a year after the FDA issued a warning about the long-term use of long-acting beta agonists, Saudi Arabian regulatory authorities have revoked marketing authorization for four such products - including GlaxoSmithKline’s Serevent and Foradil, which is sold by Novartis - over increased risks of worsening asthma symptoms, hospitalizations of children and adults, and deaths. In a statement, the SFDA says recent evidence found that LABAs were associated with increased risk of asthma-related deaths, intubation (the placement of a tube into the windpipe) and hospitalization of 2.8 percent for every 1,000 patients using a long-acting beta agonist compared to those who did not use such a medication. In analyzing data, the agency noted there were 16 deaths among LABA patients versus ... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=4179523 Thu, 18 Nov 2010 13:28:42 +0100 4179523 http://www.medworm.com/index.php?rid=3287809&cid=t_437924_111_f&fid=36048&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FAHeartyLife%2F%7E3%2FIRWQnw1WH60%2F They seem to be everywhere: medication pumps and devices for people with asthma. For people who have asthma, these pumps and inhalers are literal life savers sometimes. Asthma medications that are inhaled by pump, disk, or inhaler, come in a couple of categories: Immediate action and prophylactic (preventative), although some medications provide a bit of both. The immediate action medications are ones such as Ventolin, which helps open the airways and allows for air exchange. The preventative ones often have long-acting beta agonist, or LABA, in them, to help keep the airway open. These medications include Advair and Symbicort, which combine LABA with corticosteroids, and Serevent and Foradi, which contain the LABA only. Because these inhaled versions of medication are everywhere, it does ... A Hearty Life blogs http://www.medworm.com/rss/comments.php?id=3287809 Fri, 19 Feb 2010 15:16:53 +0100 3287809 http://www.medworm.com/index.php?rid=2584410&cid=t_437924_151_f&fid=36896&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FSuboxoneTalkZone%2F%7E3%2FIU-lNRW3NrE%2F For those of you who like to do some scientific reading, a recent meta-analysis looked at clonidine’s efficacy in reducing the symptoms of opiate withdrawal.  A meta-analysis, by the way, is when someone takes a number of studies that sometimes didn’t reach significant conclusions and combines the numbers, creating a larger study group that sometimes shows significant results that were missed in the smaller study.  There are limitations to such an approach, but it is still a common approach to looking at infrequent things.    The infamous ‘black box warnings’ on SSRIs about suicidal ideation in children came from meta-analysis of old studies of antidepressants. Alpha2-adrenergic agonists for the management of opioid withdrawal SuboxDoc ... Suboxone Talk Zone blogs http://www.medworm.com/rss/comments.php?id=2584410 Wed, 08 Jul 2009 18:31:16 +0100 2584410 http://www.medworm.com/index.php?rid=2269130&cid=t_437924_151_f&fid=36896&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FSuboxoneTalkZone%2F%7E3%2F_Aa53zs0W9s%2F On a message board called ‘opiophile’, a person wrote about being a long-term opiate addict, then taking methadone for a couple years, then going on Suboxone for a couple years.  He eventually stopped Suboxone, and had a miserable period of withdrawal… which never, by his recollection, ever totally went away.  He works for the Democratic Party (not secret info– it was in his post) and eventually used opiate agonists again (hydrocodone and oxycodone)… during his time in DC for the Obama inaugauration.  He described how wonderful he felt, experiencing the opiate sensations while at the same time ‘being part of history’. He returned to normal, boring, miserable life… until discovering a source for ‘Kratom’.  Kratom is a plant imp... Suboxone Talk Zone blogs http://www.medworm.com/rss/comments.php?id=2269130 Sun, 15 Mar 2009 16:22:42 +0100 2269130 http://www.medworm.com/index.php?rid=2018094&cid=t_437924_150_f&fid=35777&url=http%3A%2F%2Ffeeds.feedburner.com%2F%7Er%2FPharmalot%2F%7E3%2F476110210%2F In an advance of an advisory committee meeting next week, FDA staffers are recommending approval be withdrawn for several asthma meds known as long-acting beta agonists, or LABAs, for children younger than 18 years old, due to an increased risk of asthma-related deaths and attacks (back story here and here on FDA concerns and requests for more data). The drugs include Glaxo’s Advair and Serevent, AstraZeneca’s Symbicort and Novartis’ Foradil, which Schering-Plough markets in the US. The FDA staffers, in fact, also urge yanking approval of Serevent and Foradil for asthma in people of all ages and question whether LABAs should still be approved for treating ashtma (these are the FDA briefing materials). Serevent and Foradil contain LABAs only, while Advair and Symbicort com... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=2018094 Fri, 05 Dec 2008 22:24:51 +0100 2018094 http://www.medworm.com/index.php?rid=934022&cid=t_437924_122_f&fid=35055&url=http%3A%2F%2Fsarasotaneurology.com%2F2007%2F10%2F08%2Fnew-findings-in-restless-legs-syndrome%2F One of the most frustrating neurological conditions is restless legs syndrome (RLS.) It is characterized by an intense overwhelming need to move your legs at night or when sitting or resting. This can be so severe that affected individuals have difficulty sitting through a movie or driving in a car for any distance. Occasionally RLS can be associated with abnormal sensation, particularly in the feet and lower legs. The abnormal sensory symptoms are a form of peripheral neuropathy that is associated with RLS. Symptoms can be so severe as to be an impairment to sleep and feeling of well being. RLS is consider to be a form of sleep disorder, even though individuals can have symptoms during the day, while awake. New research findings that were reported in the New England Journal of Medicine in... Sarasota Neurology blogs http://www.medworm.com/rss/comments.php?id=934022 Mon, 08 Oct 2007 11:13:34 +0100 934022 http://www.medworm.com/index.php?rid=894215&cid=t_437924_122_f&fid=35055&url=http%3A%2F%2Fsarasotaneurology.com%2F2007%2F09%2F24%2Ffda-approves-new-alzheimers-medication-patch%2F The FDA has recently approved the dementia fighting drug Exelon in a patch form. The new formulation, Transdermal Exelon, offers patients a new and unique way to get medication which can help with improving cognitive function and slow down memory loss in patients suffering from Alzheimer’s disease. The new patch is also FDA approved for patients with Parkinson associated dementia. This is the second patch approved for use in treatment of Parkinson disease. The other is Neupro, a transdermal patch containing the dopamine agonist rotigotine. Transdermal Exelon joins the group of other medications used to treat Alzheimer’s disease, such as Aricept, Razadyne and Namenda. The patch for of Exelon offers the advantage of not having to take a pill twice daily, continuous medication adm... Sarasota Neurology blogs http://www.medworm.com/rss/comments.php?id=894215 Mon, 24 Sep 2007 11:04:16 +0100 894215