MedWorm provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest medical blog items that have been tagged with 'amino acids'. Sat, 03 Sep 2011 02:23:44 +0100 http://www.medworm.com/index.php?rid=5174664&cid=t_172098_109_f&fid=34750&url=http%3A%2F%2Fpsychcentral.com%2Fblog%2Farchives%2F2011%2F08%2F29%2Fnutritional-supplements-to-treat-adhd-bipolar-depression-empowerplus%2F In this study, only 49 percent of the participants kept providing the researchers data at 6 months — meaning the majority of them dropped out of the study before the 6 months were up! LOCF is generally frowned upon in good research unless there’s a very good rationale for its use. Why? Because research shows that this method gives a biased estimate of the treatment effect and underestimates the variability of the estimated result. In other words, it stacks the deck to demonstrate a treatment’s effectiveness — even when it might not be. It’s a research slight of hand. The bigger problem with this study and most of the studies cited by TrueHope is that they all suffer from significant design problems. All are open-label designs with biased, self-selected samples... World of Psychology blogs http://www.medworm.com/rss/comments.php?id=5174664 Mon, 29 Aug 2011 15:45:54 +0100 5174664 http://www.medworm.com/index.php?rid=4841826&cid=t_172098_131_f&fid=35007&url=http%3A%2F%2Fbooks.mcgraw-hill.com%2Fmedical%2Fommbid%2Fblog%2F2011%2F03%2F27%2Fpathophysiology-of-ucds%2F Ammonia accumulation in urea cycle defects (UCDs) leads to several cellular dysfunctions such as amino acid disturbances and disrupted neurotransmitter signaling (reviewed in Braissant et al, 2010, Mol Genet Metab 100 Suppl 1:S3-S12). Also, the pathophysiology of UCDs does not simply involve ammonia, and this is clinically supported by the fact that specific clinical features are seen in some UCDs and not others (such as hypertension in ASL deficiency, which could be cause by nitric oxide deficiency). Indeed, creatine synthesis in the brain can be altered by either an accumulation or deficiency of arginine (Brosnan et al, 2010, Mol Genet Metab 100 Suppl 1:S49-S52). Philippe Campeau (Source: The OMMBID Blog) The OMMBID Blog blogs http://www.medworm.com/rss/comments.php?id=4841826 Mon, 28 Mar 2011 01:20:47 +0100 4841826 http://www.medworm.com/index.php?rid=4305112&cid=t_172098_151_f&fid=36896&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FSuboxoneTalkZone%2F%7E3%2FAKUTLpy0n0M%2F Aarghh! (he said, moaning in frustration…)  I realize that it isn’t so much anger that shortens our lives as much as the repression of that anger—so pardon my venting!  I just finished an appointment with a patient who described something that is all too common, and that really makes my blood boil. I’ve seen ‘Tom’ in my practice for about three years, since he presented with severe heroin addiction.  He once made good money working in the financial industry, but was reduced by addiction to a shadow of his former self.  He had infections in his arms from using needles, to the point of being in danger of losing one of his arms because of destruction of the limb’s blood supply.  He had tried stopping dozens of times without success, having only several ‘clean days’ in a... Suboxone Talk Zone blogs http://www.medworm.com/rss/comments.php?id=4305112 Sun, 02 Jan 2011 17:27:41 +0100 4305112 http://www.medworm.com/index.php?rid=4055889&cid=t_172098_131_f&fid=35007&url=http%3A%2F%2Fbooks.mcgraw-hill.com%2Fmedical%2Fommbid%2Fblog%2F%3Fp%3D1340 This study concludes that sapropterin results in increased stability of blood phenylalanine levels in BH4-responsive PKU. Sapropterin therapy increases stability of blood phenylalanine levels in patients with BH4-responsive phenylketonuria (PKU). Burton et al. Mol Genet Metab. 2010 Oct-Nov;101(2-3):110-4. Epub 2010 Jun 27. posted by Yannis Trakadis   (Source: The OMMBID Blog) The OMMBID Blog blogs http://www.medworm.com/rss/comments.php?id=4055889 Mon, 11 Oct 2010 04:56:19 +0100 4055889 http://www.medworm.com/index.php?rid=3938421&cid=t_172098_122_f&fid=36582&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FSharpBrains%2F%7E3%2FncOsKc_7GXs%2F Many parents, health care professionals, and educators agree that there is a pressing need to develop effective treatments for ADHD to complement or substitute for traditional medication and behavior therapy approaches. This is because such treatments do not work for everyone, important difficulties often remain even when these treatments are effective, and evidence for the long-term benefits of these treatments remains less compelling than one would like. In addition, in the case of medication treatment, some individuals experience intolerable side effects and many have concerns about taking ADHD medication for an extended period. One alternative approach to treating ADHD has relied on the use of Compound Herbal Preparations (CHP) derived from traditional Chinese medicine. Practitioners o... SharpBrains blogs http://www.medworm.com/rss/comments.php?id=3938421 Mon, 06 Sep 2010 11:05:56 +0100 3938421 http://www.medworm.com/index.php?rid=2381153&cid=t_172098_151_f&fid=36896&url=http%3A%2F%2Fsuboxonetalkzone.com%2F%3Ffeed%3Drss A question from a reader: I had a very serious back injury and was prescribed pain medications for this and it snowballed from there. I went from taking percocet for pain as prescribed to stealing oxycontin and crushing it whole just to stay out of withdrawal in a matter of a couple years. While I never injected or snorted anything, I feel my addiction was just as serious as a heroine abuser. I was also never caught at work or luckily in any legal trouble. But, I lost friends and family and most of all my self esteem and my health began to deteriorate. I looked in the mirror one day and completely broke down when I saw what I had become.  I am now beginning my journey to recovery which is much harder than I had ever imagined. I am trying to do it the natural way. While I find suboxone to ... Suboxone Talk Zone blogs http://www.medworm.com/rss/comments.php?id=2381153 Thu, 30 Apr 2009 04:26:39 +0100 2381153 http://www.medworm.com/index.php?rid=2321724&cid=t_172098_129_f&fid=36038&url=http%3A%2F%2Fwww.everydayhealth.com%2Fblog%2Ftrevis-life-with-multiple-sclerosis-ms%2Fnext-generation-interferons-for-ms%2F Oral drugs are the hottest topic among people living with multiple sclerosis.  We are all tired of daily, weekly injections (sometimes thrice weekly!), monthly or quarterly infusions.  “If only a pill for this” seems to be a mantra. The thing is: no drug is without potential (and in the case of MS, serious) side effects. Then you may ask, “what about the people who are stable on their current meds?”  If you are doing “well” on your current drugs, is it even a good idea to switch for the simple reason of convenience? I attended a meeting a few weeks ago where I learned about the next generation of “injectables” and it seems pretty interesting. This particular drug was a new version of the Interferon Beta drugs.  Unlike the current formulat... Life with MS blogs http://www.medworm.com/rss/comments.php?id=2321724 Fri, 03 Apr 2009 22:02:41 +0100 2321724 http://www.medworm.com/index.php?rid=2295346&cid=t_172098_131_f&fid=35007&url=http%3A%2F%2Fbooks.mcgraw-hill.com%2Fmedical%2Fommbid%2Fblog%2F%3Fp%3D1295 This article highlights the importance of investigating for possible deletions when mutations are not found for genetic disorders. Good reading, Philippe Campeau (Source: The OMMBID Blog) The OMMBID Blog blogs http://www.medworm.com/rss/comments.php?id=2295346 Sun, 22 Mar 2009 20:16:04 +0100 2295346 http://www.medworm.com/index.php?rid=1625648&cid=t_172098_131_f&fid=35007&url=http%3A%2F%2Fbooks.mcgraw-hill.com%2Fmedical%2Fommbid%2Fblog%2F%3Fp%3D1286 This study performed by 8 US sites included 183 patients. The data was obtained by interviews, physical examinations, neuropsychological testing and laboratory analyses. OTC deficiency was the most frequent condition. 39% of all patients had intellectual and developmental disabilities. For more details on this very useful cross-sectional study, please refer to: Mol Genet Metab. 2008 Aug;94(4):397-402. Epub 2008 Jun 17. Cross-sectional multicenter study of patients with urea cycle disorders in the United States. Tuchman M, Lee B, Lichter-Konecki U, Summar ML, Yudkoff M, Cederbaum SD, Kerr DS, Diaz GA, Seashore MR, Lee HS, McCarter RJ, Krischer JP, Batshaw ML; Urea Cycle Disorders Consortium of the Rare Diseases Clinical Research Network. Thank you very much in advance for your contribution... The OMMBID Blog blogs http://www.medworm.com/rss/comments.php?id=1625648 Tue, 15 Jul 2008 15:54:53 +0100 1625648 http://www.medworm.com/index.php?rid=1371918&cid=t_172098_87_f&fid=34872&url=http%3A%2F%2Fwww.healthbolt.net%2F2008%2F04%2F14%2Frandom-fact-of-the-day-stress-does-cause-gray-hair%2F Just the news you wanted to hear to start your week, right? Sorry, but it’s true. Stress can, in fact, cause your hair to gray. Why? Stress hormones like cortisol can mess with melanocytes (simply, hair cells). Suddenly, the cells have trouble surviving and/or producing the pigment that keeps your hair its original color. Hence, those pigments disappear and out pops a gray (or white) hair. Naturally, controlling stress is a good defense in this type of situation, but that might not always be possible. Eating foods rich in the amino acids lysine and arginine can help provide a drop in stress, however, so if you’re feeling a bit on edge, grab some peanuts and a carton of yogurt. These superfoods can get you halfway to the recommended 3 grams of lysine and arginine that Slovakian... Healthbolt blogs http://www.medworm.com/rss/comments.php?id=1371918 Tue, 15 Apr 2008 03:13:59 +0100 1371918 http://www.medworm.com/index.php?rid=1271850&cid=t_172098_131_f&fid=34989&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FGeneticsHealth%2F%7E3%2F244491118%2F All amino acids are “left handed” (Image courtesy of www.answersingenesis.com)  Scientists have long known that most compounds in living things exist in mirror-image forms. The two forms are like hands; one is a mirror reflection of the other. They are different, cannot be superimposed, yet identical in their parts. When scientists synthesize these molecules in the laboratory, half of a sample turns out to be “left-handed” and the other half “right-handed.” But amino acids, which are the building blocks of terrestrial proteins, are all “left-handed,” while the sugars of DNA and RNA are “right-handed”. Years ago Arizona State University’s Sandra Pizzarello and professor emeritus John Cronin analyzed amino acids from the Mur... Genetics and Health blogs http://www.medworm.com/rss/comments.php?id=1271850 Sun, 02 Mar 2008 21:21:01 +0100 1271850 http://www.medworm.com/index.php?rid=1079740&cid=t_172098_131_f&fid=35007&url=http%3A%2F%2Fbooks.mcgraw-hill.com%2Fmedical%2Fommbid%2Fblog%2F%3Fp%3D1111 Chantale Langlois, Rossana Jorquera, Diana Orejuela, Anne Bergeron, Milton J. Finegold, William J. Rhead and Robert M. Tanguay, Rescue from neonatal death in the murine model of hereditary tyrosinemia by glutathione monoethylester and vitamin C treatment, Molecular Genetics and MetabolismIn Press, Corrected Proof, , Available online 26 November 2007. (http://www.sciencedirect.com/science/article/B6WNG-4R70K78-2/2/86c9b26444612b49174abacbbe922884) In this article, the authors describe the administration of antioxidants to a mouse model of tyrosinemia type 1. The treatment prevented neonatal death, but the disease still progressed in the mice. Perhaps antioxidants could be used in the future in conjunction with NTBC, if further experiments in mice show that combination therapy decreases the ... The OMMBID Blog blogs http://www.medworm.com/rss/comments.php?id=1079740 Sat, 08 Dec 2007 01:07:14 +0100 1079740 http://www.medworm.com/index.php?rid=1036926&cid=t_172098_131_f&fid=35007&url=http%3A%2F%2Fbooks.mcgraw-hill.com%2Fmedical%2Fommbid%2Fblog%2F%3Fp%3D1104 This study by Salt Lake City investigators looks at a new noninvasive method to measure phenylalanine, by skin iontophoretic extraction.   J Inherit Metab Dis. 2007 Oct 5; [Epub ahead of print] Noninvasive measurement of phenylalanine by iontophoretic extraction in patients with phenylketonuria. Longo N, Li SK, Yan G, Kochambilli RP, Papangkorn K, Berglund D, Ghanem AH, Ashurst CL, Ernst SL, Pasquali M, Higuchi WI.   Thank you very much in advance for your contributions to this blog (Click on login to register and post a comment). Click this link to see the most recent online abstracts of major genetics journals. Philippe Campeau, MD Resident in Medical Genetics at McGill University OMMBID Blog Administrator (Source: The OMMBID Blog) The OMMBID Blog blogs http://www.medworm.com/rss/comments.php?id=1036926 Mon, 19 Nov 2007 19:52:08 +0100 1036926 http://www.medworm.com/index.php?rid=629215&cid=t_172098_131_f&fid=35007&url=http%3A%2F%2Fbooks.mcgraw-hill.com%2Fmedical%2Fommbid%2Fblog%2F%3Fp%3D189   A trial with N-carbamylglutamate may not detect all patients with NAGS deficiency and neonatal onset A. Nordenström, M. Halldin, B. Hallberg & J. Alm Journal of Inherited Metabolic Disease The patient described in this paper has N-Acetylglutamate synthase deficiency. However, he did not initially respond to N-carbamylglutamate. Therefore, the authors recommend that conventional hyperammonemia treatment should not be delayed by a N-carbamylglutamate loading test, but that this drug should still be included in the initial treatment of patients with hyperammonemia of unknown cause.   Thank you very much in advance for your contributions to this blog (Click on login to register and post a message). Philippe Campeau, MD Resident in Medical Genetics at McGill University OMMBID Blog Adm... The OMMBID Blog blogs http://www.medworm.com/rss/comments.php?id=629215 Sun, 20 May 2007 19:49:43 +0100 629215