MedWorm provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest medical blog items that have been tagged with 'amyloid'. Sat, 03 Sep 2011 02:01:25 +0100 http://www.medworm.com/index.php?rid=4872258&cid=t_109726_122_f&fid=34755&url=http%3A%2F%2Fneuropsychological.blogspot.com%2F2011%2F05%2Falzheimers-and-bapineuzumab-j-will-seek.html J&J Will Seek FDA Approval by 2013 for Alzheimer’s DrugBloomberg NewsBy Alex NussbaumMay 26, 2011 10:38 AM CTRead the news article (Source: BrainBlog) BrainBlog blogs http://www.medworm.com/rss/comments.php?id=4872258 Thu, 26 May 2011 17:09:00 +0100 4872258 http://www.medworm.com/index.php?rid=4813669&cid=t_109726_150_f&fid=35777&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FPharmalot%2F%7E3%2FVsf-59_lCGQ%2F In a blistering missive, the Public Citizen consumer group has charged that researchers with ties to Eli Lilly withheld important data from the Journal of the American Medical Association concerning their recent study of an imaging agent for Alzheimer’s disease. Last March, the FDA declined to approve the drug over concerns that scans can be accurately read, but Lilly continues to seek approval. In a letter published yesterday in JAMA, Public Citizen criticized the January 19 study, which examined whether brain scans using Lilly’s Amyvid, an experimental dye to detect brain abnormalities, was effective. However, the consumer group charged the authors excluded data on the extent to which the scans could be intepreted accurately from one doctor to the next (here is the study and ... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=4813669 Wed, 11 May 2011 13:26:24 +0100 4813669 http://www.medworm.com/index.php?rid=4399677&cid=t_109726_122_f&fid=36582&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FSharpBrains%2F%7E3%2Fk7HhdSXLx0w%2F This article from the Washington Post explains how neuroplasticity will help Rep. Gabrielle Giffords recover from her brain injury: brain reorganization after injury is far more common and extensive than previously thought … neuroplasticity depends to a great degree on experience — which is to say, what the brain is forced to do in the critical weeks and months after it is injured. When an area with a specific function is destroyed, the brain first attempts to recruit nearby cells, which are often doing similar tasks, to change and perform the function of the destroyed cells. . 2. In this study, Dr. Yaffe and her colleagues measured risks of Alzheimer’s by measuring beta amyloid (the protein fragment that makes up Alzheimer’s plaque) levels in the blood. They found that the less ... SharpBrains blogs http://www.medworm.com/rss/comments.php?id=4399677 Tue, 25 Jan 2011 17:07:27 +0100 4399677 http://www.medworm.com/index.php?rid=4377664&cid=t_109726_122_f&fid=34755&url=http%3A%2F%2Fneuropsychological.blogspot.com%2F2011%2F01%2Ffda-pcns-drugs-advisory-committee_20.html A fuller report from The New York Times:F.D.A. Sees Promise in Alzheimer’s Imaging DrugBy GINA KOLATAThe New York TimesPublished: January 20, 2011"A committee voted that the agency should approve the first test that can show the characteristic plaques of Alzheimer’s disease in the brain of a living person."Read the full article (Source: BrainBlog) BrainBlog blogs http://www.medworm.com/rss/comments.php?id=4377664 Fri, 21 Jan 2011 01:59:00 +0100 4377664 http://www.medworm.com/index.php?rid=4372133&cid=t_109726_122_f&fid=34755&url=http%3A%2F%2Fneuropsychological.blogspot.com%2F2011%2F01%2Falzheimers-products.html FromThe New York Times:Tests Show Promise for Early Diagnosis of Alzheimer’sBy GINA KOLATAThe New York TimesPublished: January 18, 2011"Researchers report major advances on two vexing questions about Alzheimer’s: How do you know if someone who is demented has it? And how can you screen the general population for risk?"Read the full article.The report includes discussion about this week's forthcoming FDA Advisory Committee discussion about Avid Radiopharmaceuticals product. (Source: BrainBlog) BrainBlog blogs http://www.medworm.com/rss/comments.php?id=4372133 Wed, 19 Jan 2011 01:14:00 +0100 4372133 http://www.medworm.com/index.php?rid=4249136&cid=t_109726_122_f&fid=34755&url=http%3A%2F%2Fneuropsychological.blogspot.com%2F2010%2F12%2Falzheimers-impaired-beta-amyloid.html From the NIH:Impaired clearance, not overproduction of toxic proteins, may underlie Alzheimer’s disease09 December 2010In Alzheimer's disease, a protein fragment called beta-amyloid accumulates at abnormally high levels in the brain. Now researchers funded by the National Institutes of Health have found that in the most common, late-onset form of Alzheimer’s disease, beta-amyloid is produced in the brain at a normal rate but is not cleared, or removed from the brain, efficiently. In addition to improving the understanding of what pathways are most important in development of Alzheimer's pathology, these findings may one day lead to improved biomarker measures for early diagnosis as well as a new approach to treating this devastating disorder.Many believe that accumulation of abnormal l... BrainBlog blogs http://www.medworm.com/rss/comments.php?id=4249136 Fri, 10 Dec 2010 07:43:00 +0100 4249136 http://www.medworm.com/index.php?rid=3714108&cid=t_109726_83_f&fid=34856&url=http%3A%2F%2Finsidesurgery.com%2F2010%2F06%2Famyloidosis%2F Pathophysiology 1) deposition of fibrous, insoluble amyloid protein in extracellular matrices of body 2) clinically ranges from benign to severe sequelae 3) classification is based on fibril-forming protein 4) most common systemic types – primary (idiopathic), secondary, and familial amyloid polyneuropathy (FAP) (Source: Inside Surgery) Inside Surgery blogs http://www.medworm.com/rss/comments.php?id=3714108 Thu, 01 Jul 2010 00:45:16 +0100 3714108 http://www.medworm.com/index.php?rid=3482689&cid=t_109726_139_f&fid=38879&url=http%3A%2F%2Fmedia.rawvoice.com%2Fpmn_twiv%2Fwww.twiv.tv%2FTWiV078.mp3 Hosts: Vincent Racaniello, Alan Dove, Dickson Despommier, and Rich Condit Vincent, Alan, Dickson, and Rich talk about treating arthritis with a tanapox virus protein, Darwinian evolution of prions in cell culture, and the connection between cold weather fronts and outbreaks of avian H5N1 influenza in Europe. This episode is sponsored by Data Robotics Inc. Use the promotion code TWIVPOD to receive $75-$500 off a Drobo. Win a free Drobo S! Contest rules here. Download TWiV #78 (53 MB .mp3, 73 minutes) Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email. Links for this episode: Treating arthritis with a tanapox virus protein that antagonizes TNF (press release and research article) Darwinian evolution of prions in cell culture (abstract) Simple diagram ... virology blog blogs http://www.medworm.com/rss/comments.php?id=3482689 Sun, 18 Apr 2010 16:56:38 +0100 3482689 http://www.medworm.com/index.php?rid=3346578&cid=t_109726_122_f&fid=34755&url=http%3A%2F%2Fneuropsychological.blogspot.com%2F2010%2F03%2Falzheimers-disease-beta-and-immune.html Old Enemy Might Help to Prevent Alzheimer’sBy GINA KOLATAThe New York TimesPublished: March 8, 2010"Harvard researchers are taking a new look at beta amyloid, which was thought to be a chief villain in Alzheimer’s whose function was that of a waste product in the brain."Read the full article (Source: BrainBlog) BrainBlog blogs http://www.medworm.com/rss/comments.php?id=3346578 Mon, 08 Mar 2010 23:02:00 +0100 3346578 http://www.medworm.com/index.php?rid=3216168&cid=t_109726_139_f&fid=38879&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FVirologyBlog%2F%7E3%2FCJBHpj7d-rk%2F Fragments of an abundant protein produced by the prostate form amyloid fibrils that enhance infection of cells by human immunodeficiency virus type 1. These fibrils, called semen-derived enhancer of virus infection (SEVI), have been found to boost infection of prostate cells by the retrovirus XMRV. Is this evidence that XMRV causes prostate cancer? Because most HIV-1 infections are a consequence of genital exposure to semen of virus-infected men, seminal fluid was screened for peptides or proteins that enhance viral infectivity. Peptides (34 – 40 amino acids in length) derived from prostatic acidic phosphates, a common protein found in semen, were found to dramatically enhance HIV-1 infection of cultured cells. These peptide fragments form amyloid fibrils which bind both virions and ... virology blog blogs http://www.medworm.com/rss/comments.php?id=3216168 Thu, 28 Jan 2010 03:13:24 +0100 3216168 http://www.medworm.com/index.php?rid=2923445&cid=t_109726_137_f&fid=35426&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FTheAlzheimersReadingRoom%2F%7E3%2FqzxGa5HxXxE%2Fmanipulating-brain-inflammation-may.html In a surprising reversal of long-standing scientific belief, researchers at the Mayo Clinic campus in Florida have discovered that... Comments welcome.....Sharing Welcome...Did you see the Worried About Alzheimer's series? (Source: Alzheimer's Reading Room, The) Alzheimer's Reading Room, The blogs http://www.medworm.com/rss/comments.php?id=2923445 Sat, 24 Oct 2009 08:22:00 +0100 2923445 http://www.medworm.com/index.php?rid=2851967&cid=t_109726_131_f&fid=34989&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FGeneticsHealth%2F%7E3%2F4lh20j6D4h4%2F A good eight hours of sleep really does our life good, well into the twilight years! A new study has found that sleep abnormalities in midlife may be linked to the onset of Alzheimer’s later in life. Chronic sleep abnormalities include  insomnia, late-night habits, sleep deprivation and irregular sleep habits. Alzheimer’s is triggered as the peptide amyloid-beta transforms into plaque in the brain’s fluid, and amyloid-beta naturally increases during the day and decreases at night. Published in Science Express, neurologist Jae-Eun Kang and her colleagues found, in both men and mice, that concentrations of amyloid-beta increases during periods of sleep deprivation. When the researchers kept mice awake for an extra 6 hours, the levels of amyloid-beta spiked. So the scientists are ... Genetics and Health blogs http://www.medworm.com/rss/comments.php?id=2851967 Wed, 30 Sep 2009 22:13:00 +0100 2851967 http://www.medworm.com/index.php?rid=2630234&cid=t_109726_122_f&fid=34755&url=http%3A%2F%2Fneuropsychological.blogspot.com%2F2009%2F07%2Falzheimers-disease-amyloid-jitteriness.html A Bloomberg News report about the state of clinical trials of those Alzheimer's disease candidates in the processes/stages in amyloid levels and amyloid deposition: read article here (Source: BrainBlog) BrainBlog blogs http://www.medworm.com/rss/comments.php?id=2630234 Wed, 22 Jul 2009 20:21:00 +0100 2630234 http://www.medworm.com/index.php?rid=2606201&cid=t_109726_137_f&fid=35426&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FTheAlzheimersReadingRoom%2F%7E3%2FZ2mmDsqxq-s%2Fdimebolin-increases-brain-beta-amyloid.html "This result is highly unexpected in what may prove to be a clinically beneficial Alzheimer's drug," Samuel Gandy said. "We need more research to further clarify how dimebolin affects beta amyloid levels in the brain.""A number of ideas need to be pursued. It may turn out that the drug works by getting toxic amyloid out of brain nerve cells. Or, the effects of dimebolin on other brain systems may override its effect on increasing beta amyloid. Finally, the drug's beneficial actions might have nothing to do with amyloid, which, if true, indicates the existence of important therapeutic targets independent of beta amyloid," Gandy added.For more Insight into Alzheimer's DiseaseSubscribe to The Alzheimer's Reading RoomSurprisingly, Dimebolin Increases Brain Beta Amyloid in Alzheimer's Mouse Mod... Alzheimer's Reading Room, The blogs http://www.medworm.com/rss/comments.php?id=2606201 Thu, 16 Jul 2009 01:06:36 +0100 2606201 http://www.medworm.com/index.php?rid=2606200&cid=t_109726_137_f&fid=35426&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FTheAlzheimersReadingRoom%2F%7E3%2FY3bw0QgKeZI%2Fimmunotherapy-against-tau-tangles-in.html "We believe that these results point to the therapeutic potential of phosphorylated-tau-immunotherapy in Alzheimer's," Rosenmann said. "We devoted significant effort to address not only the anti-tangle effect but also safety of a phosphorylated-tau vaccine. This was done in order to identify early in the preclinical stage any potential hazard of this potential Alzheimer's therapy."For more Insight into Alzheimer's DiseaseSubscribe to The Alzheimer's Reading RoomImmunotherapy Against Tau Tangles in Alzheimer's Mouse ModelsImmunotherapy (treatment by inducing, enhancing, or suppressing an immune response) targeting beta amyloid is being researched widely by companies and academics as a therapeutic option for Alzheimer's disease. Earlier, late stage, anti-amyloid immunotherapy trials in peopl... Alzheimer's Reading Room, The blogs http://www.medworm.com/rss/comments.php?id=2606200 Wed, 15 Jul 2009 13:09:12 +0100 2606200 http://www.medworm.com/index.php?rid=2602198&cid=t_109726_137_f&fid=35426&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FTheAlzheimersReadingRoom%2F%7E3%2FZ2mmDsqxq-s%2Fdimebolin-increases-brain-beta-amyloid.html "This result is highly unexpected in what may prove to be a clinically beneficial Alzheimer's drug," Samuel Gandy said. "We need more research to further clarify how dimebolin affects beta amyloid levels in the brain.""A number of ideas need to be pursued. It may turn out that the drug works by getting toxic amyloid out of brain nerve cells. Or, the effects of dimebolin on other brain systems may override its effect on increasing beta amyloid. Finally, the drug's beneficial actions might have nothing to do with amyloid, which, if true, indicates the existence of important therapeutic targets independent of beta amyloid," Gandy added.For more Insight into Alzheimer's DiseaseSubscribe to The Alzheimer's Reading RoomSurprisingly, Dimebolin Increases Brain Beta Amyloid in Alzheimer's Mouse Mod... Alzheimer's Reading Room, The blogs http://www.medworm.com/rss/comments.php?id=2602198 Wed, 15 Jul 2009 11:46:29 +0100 2602198 http://www.medworm.com/index.php?rid=2602203&cid=t_109726_137_f&fid=35426&url=http%3A%2F%2Fwww.alz.org%2Ficad%2Fdocuments%2Fabstracts%2Fabstracts_biomarkers_ICAD09.pdf Changes in the brain measured with MRI and PET scans, combined with memory tests and detection of risk proteins in body fluids, may lead to earlier and more accurate diagnosis of Alzheimer's, according to new research reported today at the Alzheimer's Association 2009 International Conference on Alzheimer's Disease (ICAD 2009) in Vienna.For more Insight into Alzheimer's DiseaseSubscribe to The Alzheimer's Reading RoomNew Results from ADNI Data Bring Us Closer to Earlier Detection of Alzheimer's Vienna, July 14, 2009 – Changes in the brain measured with MRI and PET scans, combined with memory tests and detection of risk proteins in body fluids, may lead to earlier and more accurate diagnosis of Alzheimer's, according to new research reported today at the Alzheimer's Association 2009 Inter... Alzheimer's Reading Room, The blogs http://www.medworm.com/rss/comments.php?id=2602203 Tue, 14 Jul 2009 16:24:42 +0100 2602203 http://www.medworm.com/index.php?rid=2580350&cid=t_109726_117_f&fid=36026&url=http%3A%2F%2Fwww.everydayhealth.com%2Fblog%2Fzimney-health-and-medical-news-you-can-use%2Fcaffeine-cures-alzheimers-and-other-misleading-headlines%2F Not really, but I’d imagine that headline caught your eye and grabbed your attention, which is what it was supposed to do. The study on which that claim is based was widely and often quite misleadingly trumpeted across the Internet yesterday (July 6, 2009). Although some responsible sites included in the headline that the tests were done in mice, many concealed this important fact until you were well into the article and had already been exposed to whatever advertising was on the page. I’d already seen several misleading headlines before I realized the studies were in mice and I’m sure that many people didn’t ever get the full story. The entire webisode was set in motion by the University of South Florida Health’s press release, a slick piece of PR entitled &#... Dr. Z's Medical Report blogs http://www.medworm.com/rss/comments.php?id=2580350 Tue, 07 Jul 2009 17:37:16 +0100 2580350 http://www.medworm.com/index.php?rid=2349592&cid=t_109726_137_f&fid=35426&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FTheAlzheimersReadingRoom%2F%7E3%2FmkOsjMYc4OA%2Falzheimers-new-findings-resolve-long.html This is interesting and exciting news. Definitely worth reading and considering."When you understand these mechanisms better, you have a better chance of being able to pharmaceutically counteract them as a possible treatment. For instance, if amyloid-beta thins membranes, this general effect might be difficult to treat. On the other hand, if it forms pores, this effect might be treatable with pore blockers. Ion channel blockers are medications sold today to treat a variety of diseases," Mayer said.Follow the Alzheimer's Reading Room on TwitterSubscribe to The Alzheimer's Reading Room--via EmailFor a decade, Alzheimer's disease researchers have been entrenched in debate about one of the mechanisms believed to be responsible for brain cell death and memory loss in the illness.Now researchers... Alzheimer's Reading Room, The blogs http://www.medworm.com/rss/comments.php?id=2349592 Fri, 17 Apr 2009 16:19:19 +0100 2349592 http://www.medworm.com/index.php?rid=1658240&cid=t_109726_107_f&fid=36698&url=http%3A%2F%2Fminingdrugs.blogspot.com%2F2008%2F07%2Fquotes-from-neighbors-july-2008.html ==Receptors: Can't Live With 'Em, Can't Understand 'Em (In the pipeline)==At various points in my drug discovery career, I’ve worked on G-protein-coupled receptor (GPCR) targets. Most everyone in the drug industry has at some point – a significant fraction of the known drugs work through them, even though we have a heck of a time knowing what their structures are like.For those outside the field, GPCRs are a ubiquitous mode of signaling between the interior of a cell and what’s going on outside it, which accounts for the hundreds of different types of the things. ...==A-β Dimers- The Long-Sought Minimal Culprit in Alzheimer's Disease? (The Curious Wavefunction)==Following on the heels of the headline-making Nature publication that demonstrated that NSAIDs (Non-steroidal AntiInflamma... Mining Drug Space blogs http://www.medworm.com/rss/comments.php?id=1658240 Sun, 27 Jul 2008 19:27:00 +0100 1658240 http://www.medworm.com/index.php?rid=1618108&cid=t_109726_137_f&fid=35357&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FAlzheimersNotes%2F%7E3%2F334866458%2F The Scripps Research Institute scientists have discovered that tetrahydrocannabinol or THC, the active ingredient in marijuana inhibits the formation of amyloid plaque, a primary pathological marker for Alzheimer’s disease. The study, using both computer modeling and biochemical assays, found that THC inhibits the enzyme acetylcholinesterase (AChE). AChe works as a “molecular chaperone” and speeds up the creation of amyloid plaque in the brains of Alzheimer victims. As THC seems to be a strong inhibitor of these plaques, it could well be that it could provide therapeutic treatment for the symptoms and progression of Alzheimer’s disease. While Scripps Research scientists are quick to state that they are not advocating the use of marijuana, they do say that “&... Alzheimer's Notes blogs http://www.medworm.com/rss/comments.php?id=1618108 Mon, 14 Jul 2008 07:08:17 +0100 1618108 http://www.medworm.com/index.php?rid=1543150&cid=t_109726_109_f&fid=34750&url=http%3A%2F%2Fpsychcentral.com%2Fblog%2Farchives%2F2008%2F06%2F25%2Fpromising-new-alzheimers-research-published%2F Which came first, the beta-amyloid plaque or the Alzheimer’s? It’s the plaque, but only one subtype, according to a new report by Harvard researchers in the online journal Nature Medicine and profiled in this TIME article from Sunday. Physicians and researchers have long noted the presence of these plaques, made up of “sticky” beta-amyloid proteins, in the brains of Alzheimer’s patients, and wondered whether there might be some connection between the plaque and the disease. To complicate things, however, beta-amyloid plaques have also been found in patients with no sign of the disease, making scientists wonder whether the plaques could be an advance warning sign of Alzheimer’s rather than a byproduct of the disorder. So, how was this chicken-and-egg problem solved? Researcher... World of Psychology blogs http://www.medworm.com/rss/comments.php?id=1543150 Wed, 25 Jun 2008 06:16:46 +0100 1543150 http://www.medworm.com/index.php?rid=1419139&cid=t_109726_134_f&fid=36049&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FDiabetesNotes%2F%7E3%2F282991760%2F We have all read the recent studies linking diabetes and Alzheimer’s disease. Diabetics have an over 35% higher chance of developing Alzheimer’s then non-diabetics. That is a huge finding. Now researchers have discovered why this occurs. Neurobiology of Aging, investigators led by David R. Schubert, Ph.D., professor in the Cellular Neurobiology Laboratory, report that the blood vessels in the brain of young diabetic mice are damaged by the interaction of elevated blood glucose levels characteristic of diabetes and low levels of beta amyloid, a peptide that clumps to form the senile plaques that riddle the brains of Alzheimer’s patients. We all have small levels of amyloid circulating throughout our blood but in diabetics there is a toxic interaction between the amyloid an... Diabetes Notes blogs http://www.medworm.com/rss/comments.php?id=1419139 Sat, 03 May 2008 23:23:36 +0100 1419139 http://www.medworm.com/index.php?rid=988487&cid=t_109726_111_f&fid=36048&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FAHeartyLife%2F%7E3%2F176817444%2F And yet another link to Alzheimer’s disease from another chronic disease process… It seems that anti-hypertensives have proven to benefit in the prevention and treatment of Alzheimer’s disease. Such implications could aid in the ultimate cure and care of this dreadful mind altering disease. Just what anti-hypertensives made the list? …significantly benefit from the treatment with the anti-hypertensive agent Valsartan, found to pharmacologically prevent beta-amyloid production in the brain even when delivered to Alzheimer’s disease mice at doses 3-4 fold lower than the minimal equivalent dose prescribed for the treatment of hypertension in humans. Other anti-hypertension drugs with beneficial results included Propranolol HCI, Carvedilol, Losartan, Nicardipine H... A Hearty Life blogs http://www.medworm.com/rss/comments.php?id=988487 Mon, 29 Oct 2007 19:34:37 +0100 988487 http://www.medworm.com/index.php?rid=958838&cid=t_109726_117_f&fid=34612&url=http%3A%2F%2Fwww.thedoctorweighsin.com%2Fjournal%2F2007%2F10%2F17%2Falzheimers-disease-is-there-daylight-at-the-end-of-the-tunne.html So let’s be honest, baby boomer, aren’t you worried about turning a geezer boomer soon? After all, the first of you just got on Social Security. And what about those memory lapses? In your heart of hearts, are’nt you scared just a little bit? If you are not—read on. Here are some sobering statistics. · More than 5 million Americans are estimated to have Alzheimer’s disease or AD today. It is projected that 14.3 million Americans will have the disease by mid-century: a 350 percent increase from 2000, when there were 4 million people with the disease. Reason for the expected explosive growth: a tidal wave of aging baby boomers turning old geezers. In the United States, AD was the 7th leading cause of death in 2004 , with 65,829 number of deaths (and risin... The Doctor Weighs In blogs http://www.medworm.com/rss/comments.php?id=958838 Wed, 17 Oct 2007 00:07:25 +0100 958838 http://www.medworm.com/index.php?rid=908741&cid=t_109726_134_f&fid=36049&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FDiabetesNotes%2F%7E3%2F162104167%2F Now scientists at Northwestern University have discovered why brain insulin signaling — crucial for memory formation — would stop working in Alzheimer’s disease. They have shown that a toxic protein found in the brains of individuals with Alzheimer’s removes insulin receptors from nerve cells, rendering those neurons insulin resistant. (The protein, known to attack memory-forming synapses, is called an ADDL for “amyloid ß-derived diffusible ligand.”) I know I read something similar to this last year. There was preliminary research released stating that there is a direct correlation the way the brain uses, or misuses, insulin and the way that diabetics fight a similar battle. The most current Northwestern University study is so powerful that they are eve... Diabetes Notes blogs http://www.medworm.com/rss/comments.php?id=908741 Thu, 27 Sep 2007 22:20:05 +0100 908741 http://www.medworm.com/index.php?rid=793007&cid=t_109726_137_f&fid=35371&url=http%3A%2F%2Fthecaregiver.blogspot.com%2F2007%2F08%2Fnewly-discovered-antibody-may-be-bodys.html In what could prove to be an important development in the search for a treatment of Alzheimer's disease, NewYork-Presbyterian Hospital/Weill Cornell Medical Center physician-scientists say the results of an initial (Phase I) clinical study provide encouraging evidence that antibodies derived from human plasma can capture the beta-amyloid protein in blood and exert positive effects on patients' thinking abilities.Read more at the Alzheimer's Reading Room: Newly Discovered Antibody May Be Body's Natural Defense Against Alzheimer's (Gammagard) (Source: CareGiver, The) CareGiver, The blogs http://www.medworm.com/rss/comments.php?id=793007 Fri, 10 Aug 2007 15:47:00 +0100 793007 http://www.medworm.com/index.php?rid=696986&cid=t_109726_137_f&fid=35371&url=http%3A%2F%2Fthecaregiver.blogspot.com%2F2007%2F06%2Fclinical-trial-omega-3-fatty-acid.html This study is currently recruiting patients. Personal Note: I have been feeding my mother fish and giving her Omega 3 Oil daily for a couple of years. I believe it is beneficial.For a complete description of the trial including eligibility requirements go to the Clinical Trials PageOfficial Title: A Randomized Double-Blind Placebo-Controlled Trial Of The Effects Of Docosahexaenoic Acid (DHA) In Slowing The Progression Of Alzheimer’s DiseaseStudy Type: InterventionalStudy Design: Treatment, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Efficacy StudyFurther study details as provided by National Institute on Aging (NIA)Primary Outcome Measures:Changes in rate of cognitive and functional decline measured by ADAS-Cog and CDR-SOB Preliminary studies have shown a reduced risk... CareGiver, The blogs http://www.medworm.com/rss/comments.php?id=696986 Tue, 26 Jun 2007 15:56:00 +0100 696986 http://www.medworm.com/index.php?rid=519690&cid=t_109726_137_f&fid=35371&url=http%3A%2F%2Fthecaregiver.blogspot.com%2F2007%2F04%2Famericans-fear-alzheimers-more-than.html ConclusionAmericans fear Alzheimer’s and the impact that it could have on their lives in the coming years. And although they may recognize the need to look toward the future, the majority hasn’t started making plans.The downside of living longer has a high price: Nearly 50 percent of those who are 85 or older are affected, and the rate of Alzheimer’s increases exponentially every five years past the age of 65. And with the aging of America’s population these numbers are sure to become even more dramatic in the future, making it imperative that individuals and institutions plan for the future.The growing number of people with Alzheimer’s will have an impact on every part of society. The vast majority of people know that this disease may someday affect them, either directly or as a... CareGiver, The blogs http://www.medworm.com/rss/comments.php?id=519690 Wed, 04 Apr 2007 01:40:00 +0100 519690 http://www.medworm.com/index.php?rid=512455&cid=t_109726_137_f&fid=35350&url=http%3A%2F%2Fwww.tangledneuron.info%2Fthe_tangled_neuron%2F2007%2F03%2Fhead_injuries_a.html This study suggests that mild head trauma is not a major risk factor for dementia or AD in the elderly.” Erasmus University, The Netherlands, 1999 review of data from The Rotterdam Study of more than 6000 people - “Moderate and severe head injuries in young men may be associated with increased risk of AD and other dementias in late life. However, the authors cannot exclude the possibility that other unmeasured factors may be influencing this association.” Duke University, 2000 study of the medical records of approximately 1800 retired military personnel, 548 of whom had had head injuries - “Head injury is a risk factor for AD. The magnitude of the risk is proportional to severity and heightened among first-degree relatives of AD patients.” Boston University, 2000 review of da... The Tangled Neuron blogs http://www.medworm.com/rss/comments.php?id=512455 Thu, 22 Mar 2007 14:20:31 +0100 512455 http://www.medworm.com/index.php?rid=513011&cid=t_109726_137_f&fid=35371&url=http%3A%2F%2Fthecaregiver.blogspot.com%2F2007%2F03%2Falzheimers-reading-room-weblog-myriad.html Myriad Genetics, Inc. (NASDAQ: MYGN) (www.myriad.com) announced today that it presented additional results of its completed Phase 2 follow-on study of Flurizan™ in patients with mild Alzheimer's disease at the annual meeting of the American Association for Geriatric Psychiatry (AAGP), held March 1-4, 2007 in New Orleans.Read the release in its entirety at The Alzheimer's Reading Room Weblog (Source: CareGiver, The) CareGiver, The blogs http://www.medworm.com/rss/comments.php?id=513011 Tue, 06 Mar 2007 00:46:00 +0100 513011 http://www.medworm.com/index.php?rid=513010&cid=t_109726_137_f&fid=35371&url=http%3A%2F%2Fthecaregiver.blogspot.com%2F2007%2F02%2Fnew-drug-stops-alzheimers-in-tracks.html The drug -- called Alzhemed -- attacks Amyloid Peptide - the molecule that causes Alzheimer's.Paul Aisen, M.D.: "I think it is tremendously significant."An early study showed Alzhemed stabilized the disease in nearly half of patients. Now, more than 1,000 are being followed. Source ABC7Nearly five-million Americans are living with Alzheimer's disease. Drugs on the market can treat the symptoms -- but not one goes after what causes it. Now, researchers are on the brink of a huge breakthrough with a drug that targets the cause and could stop the disease in its tracks.Frances Goldstein: "I like to paint -- a lot."Jacobo, her husband of 45 years, loves watching her mind at work. Frances has Alzheimer's disease -- diagnosed eight years ago at age 56.Jacobo Goldstein, Wife has Alzheimer's: "For ... CareGiver, The blogs http://www.medworm.com/rss/comments.php?id=513010 Thu, 22 Feb 2007 04:53:00 +0100 513010