MedWorm provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest medical blog items that have been tagged with 'antibody'. Sat, 03 Sep 2011 02:12:03 +0100 http://www.medworm.com/index.php?rid=4921689&cid=t_159330_136_f&fid=37846&url=http%3A%2F%2Fhealthinfoispower.wordpress.com%2F2011%2F06%2F09%2F2011-asco-additional-phase-iii-study-data-support-the-potential-role-of-avastin-in-newly-diagnosed-recurrent-ovarian-cancer%2F Positive results from two bevacizumab (Avastin®) phase III clinical studies were presented at the 2011 American Society of Clinical Oncology Annual Meeting on June 4. The data reported add to the growing body of evidence in support of bevacizumab use to treat recurrent and newly-diagnosed ovarian cancer. Positive results from two bevacizumab (Avastin®) phase III [...] (Source: Libby's H*O*P*E*) Libby's H*O*P*E* blogs http://www.medworm.com/rss/comments.php?id=4921689 Thu, 09 Jun 2011 23:15:13 +0100 4921689 http://www.medworm.com/index.php?rid=4636113&cid=t_159330_139_f&fid=38879&url=http%3A%2F%2Fwww.virology.ws%2Ffib0071.flv I joined Marc Pelletier, Andre Nantel, and George Farr on episode 71 of Futures in Biotech for a conversation about the 1000 genome project, the billion dollar human proteome, how antibodies block viral infection, and capturing anti-matter. Download audio FiB #71 (42 MB .mp3, 87 minutes) Download video (211 MB .mp4) (Source: virology blog) virology blog blogs http://www.medworm.com/rss/comments.php?id=4636113 Tue, 30 Nov 2010 20:39:39 +0100 4636113 http://www.medworm.com/index.php?rid=4158813&cid=t_159330_139_f&fid=38879&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FVirologyBlog%2F%7E3%2FTmOWer8-iJc%2F Antibodies are an important component of the host defense against viral infection. These molecules, produced 7-14 days after infection, neutralize viral infectivity, thereby limiting the spread of infection. Antibodies are thought to neutralize viral infectivity in several ways: by forming noninfectious aggregates that cannot enter cells, or by blocking virion attachment to cells or uncoating (figure). A new mechanism has just joined this list, in which antibody bound virions are degraded in the cell cytoplasm. A cytoplasmic protein called TRIM21 (tripartite motif-containing 21) was recently found to bind with high affinity to the conserved regions of antibody molecules. The presence of this activity in many mammalian species suggested that there could be ways that antibodies operate withi... virology blog blogs http://www.medworm.com/rss/comments.php?id=4158813 Thu, 11 Nov 2010 18:34:51 +0100 4158813 http://www.medworm.com/index.php?rid=4017874&cid=t_159330_139_f&fid=38879&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FVirologyBlog%2F%7E3%2FXOYZJusvX68%2F Many virological techniques are based on the specificity of the antibody-antigen reaction. Examples in our virology toolbox include western blot analysis and ELISA. While very useful, these methods cannot be used to visualize viral proteins in infected cells or tissues. To do that we must turn to immunostaining. In direct immunostaining (illustrated), an antibody that recognizes a viral antigen is coupled directly to an indicator (a fluorescent dye or an enzyme). Indirect immunostaining is a more sensitive method because a second antibody is coupled to the indicator. The second antibody recognizes a common epitope on the virus-specific antibody. Multiple second antibodies can bind to the first antibody, leading to an increased signal from the indicator compared to direct immunostaining. To... virology blog blogs http://www.medworm.com/rss/comments.php?id=4017874 Thu, 30 Sep 2010 15:06:04 +0100 4017874 http://www.medworm.com/index.php?rid=3938294&cid=t_159330_83_f&fid=34856&url=http%3A%2F%2Finsidesurgery.com%2F2010%2F09%2Fprimary-biliary-cirrhosis%2F Pathophysiology 1) progressive inflammation and destruction of the intrahepatic bile ducts 2) causes development of cirrhosis 3) likely has an autoimmune component Signs and Symptoms 1) fatigue 2) jaundice 3) pruritus 4) hepatomegaly 5) splenomegaly 6) xanthelasma 7) diagnosis is often made on asymptomatic laboratory detection Characteristic Test Findings Laboratory – 1) increased alkaline phosphatase (3 times normal value) 2) mildly elevated AST and ALT 3) antimitochondrial antibody Histology/Gross Pathology Ludwig’s classification describes histology – portal and periportal scarring and fibrosis and cirrhosis Associated Conditions 1) osteoporosis 2) hypercholesterolemia 3) thyroid disease (15%) 4) scleroderma (15%) 5) joint pain 6) dry eyes/mouth (75%) 7) gallstones (30... Inside Surgery blogs http://www.medworm.com/rss/comments.php?id=3938294 Mon, 06 Sep 2010 20:20:23 +0100 3938294 http://www.medworm.com/index.php?rid=3946234&cid=t_159330_139_f&fid=38879&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FVirologyBlog%2F%7E3%2Fh1f6DEG1Yr8%2F A more rapid method than Western blot analysis to detect a specific protein in a cell, tissue, organ, or body fluid is enzyme-linked immunosorbent assay, or ELISA. This method, which does not require fractionation of the sample by gel electrophoresisis, is based on the property of proteins to readily bind to a plastic surface. To detect viral proteins in serum or clinical samples, a capture antibody, directed against the protein, is linked to a solid support such as a plastic 96 well microtiter plate, or a bead. The clinical specimen is added, and if viral antigens are present, they will be captured by the bound antibody. The bound viral antigen is then detected by using a second antibody linked to an enzyme. A chromogenic molecule – one that is converted by the enzyme to an easily ... virology blog blogs http://www.medworm.com/rss/comments.php?id=3946234 Fri, 16 Jul 2010 16:28:49 +0100 3946234 http://www.medworm.com/index.php?rid=3617782&cid=t_159330_83_f&fid=34856&url=http%3A%2F%2Finsidesurgery.com%2F2010%2F05%2Fmononucleosis%2F Pathophysiology infection with Epstein-Barr virus (or sometimes CMV with slightly different clinical presentation) in adolescence or early adulthood Signs and Symptoms 1) prodrome of fatigue, malaise, and myalgias 2) tender but mobile lymphadenopathy (especially in posterior cervical chain) 3) fever 4) exudate pharyngitis 5) splenomegaly 6) splenic rupture (0.5%) 7) mouth petechiae 8) gingivitis 9) abdominal pain 10) rash (10%) 11) symptoms usually resolve in 3-4 weeks Characteristic Test Findings Laboratory – 1) leukocytosis with at least 10% lymphocytes 2) presence of Paul-Bunnell heterophile antibody (this is the basis of the diagnostic monospot test) 3) presence of transient cold agglutinins 4) increased AST, ALT, alkaline phosphatase Histology/Gross Pathology 1) atypical lymphcy... Inside Surgery blogs http://www.medworm.com/rss/comments.php?id=3617782 Mon, 31 May 2010 18:58:03 +0100 3617782 http://www.medworm.com/index.php?rid=3311889&cid=t_159330_136_f&fid=37846&url=http%3A%2F%2Fhealthinfoispower.wordpress.com%2F2010%2F02%2F25%2Fgenentech-announces-positive-results-of-avastin-phase-iii-study-in-women-with-advanced-ovarian-cancer%2F Genentech announces positive results of Avastin Phase III study (GOG 218) in women with advanced ovarian cancer. The study showed that women who continued maintenance use of Avastin alone, after receiving Avastin in combination with chemotherapy, lived longer without the disease worsening compared to those who received chemotherapy alone. This is the first Phase [...] (Source: Libby's H*O*P*E*) Libby's H*O*P*E* blogs http://www.medworm.com/rss/comments.php?id=3311889 Thu, 25 Feb 2010 18:40:30 +0100 3311889 http://www.medworm.com/index.php?rid=3306783&cid=t_159330_83_f&fid=34856&url=http%3A%2F%2Finsidesurgery.com%2F2010%2F02%2Fsystemic-lupus-erythematous-sle%2F Pathophysiology 1) systemic disorder with tissue damage secondary to autoantibodies and immune complex deposition 2) cause is unknown but likely requires an environmental stimulus (example is ultraviolet light) in presence of many susceptibility genes Signs and Symptoms 1) butterfly rash on face 2) short hairs in frontal scalp (”lupus hairs”) 3) “carpet tack” skin lesions 4) pericarditis 5) pericardial effusions 6) pleurisy 7) pleural effusions focal or diffuse proliferative nephritis 9) abdominal pain 10) blindness 11) fatigue (often debilitating) 12) cognitive dysfunction (”lupus cerebritis”) 13) subcutaneous nodules 14) puffiness of hands and feet 15) swan-neck deformities of fingers Characteristic Test Findings Laboratory – 1) anti-ANA antibo... Inside Surgery blogs http://www.medworm.com/rss/comments.php?id=3306783 Thu, 25 Feb 2010 01:54:46 +0100 3306783 http://www.medworm.com/index.php?rid=3126477&cid=t_159330_139_f&fid=38879&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FVirologyBlog%2F%7E3%2F9F6kjjjpdzY%2F In healthy individuals, the first encounter with a virus leads to a primary antibody response. When an infection occurs with the same or a similar virus, a rapid antibody response occurs that is called the secondary antibody response. Antibodies are critical for preventing many viral infections, including influenza. But reinfection may occur if we encounter the same virus before the primary response is complete. Recently three cases of confirmed infection with 2009 influenza H1N1 were reported in Chile. The first patient had laboratory confirmed infection; treatment with oseltamivir resolved symptoms after 48 hours. Twenty days later the patient developed a second bout of laboratory confirmed influenza which was treated with amantadine. The second patient acquired laboratory confirmed i... virology blog blogs http://www.medworm.com/rss/comments.php?id=3126477 Mon, 28 Dec 2009 21:09:44 +0100 3126477 http://www.medworm.com/index.php?rid=3016941&cid=t_159330_139_f&fid=38879&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FVirologyBlog%2F%7E3%2FAAd62pyT5Ec%2F Antibodies produced by infection with a virus, or after immunization with viral vaccines, are effective at preventing viral disease. However humans and higher primates contains “natural antibodies” which are present in serum before viral infection. Natural antibodies can activate the classical complement pathway leading to lysis of enveloped virus particles long before the adaptive immune response is activated. Many natural antibodies are directed against the disaccharide galactose α(1,3)-galactose (α-Gal) (illustration), which is found as a terminal sugar on glycosylated cell surface proteins. Humans, apes, and Old World monkeys lack the gene encoding the enzyme galactosyltransferase, which attaches α-Gal to membrane proteins. Lower primates, most other animals, and bact... virology blog blogs http://www.medworm.com/rss/comments.php?id=3016941 Tue, 06 Oct 2009 17:37:01 +0100 3016941 http://www.medworm.com/index.php?rid=2662628&cid=t_159330_136_f&fid=37846&url=http%3A%2F%2Fhealthinfoispower.wordpress.com%2F2009%2F08%2F01%2Ftrojan-horse-for-ovarian-cancer-nanoparticles-turn-immune-system-soldiers-against-tumor-cells%2F In a feat of trickery, Dartmouth Medical School immunologists have devised a Trojan horse to help overcome ovarian cancer, unleashing a surprise killer in the surroundings of a hard-to-treat tumor. Using nanoparticles–ultra small bits– the team has reprogrammed a protective cell that ovarian cancers have corrupted to feed their growth, turning the cells back [...] (Source: Libby's H*O*P*E*) Libby's H*O*P*E* blogs http://www.medworm.com/rss/comments.php?id=2662628 Sat, 01 Aug 2009 21:59:42 +0100 2662628 http://www.medworm.com/index.php?rid=2741088&cid=t_159330_139_f&fid=38879&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FVirologyBlog%2F%7E3%2FXhG1BwK-CIs%2F With the looming prospect of mass immunization against influenza, it’s important to understand how vaccines work. To do this we must have a good understanding of adaptive immune defenses. Today we’ll begin a discussion of the humoral arm of the adaptive immune response – antibodies. Antibodies are large proteins produced by vertebrates that play important roles in identifying and eliminating foreign objects. The basic structural unit is composed of two heavy chains and two light chains, as shown in this diagram. Antibodies bind other molecules known as antigens. Binding occurs in a small region near the ends of the heavy and light chain called the hypervariable region (labeled only on one arm in the figure). As the name implies, this region is extremely variable, which ... virology blog blogs http://www.medworm.com/rss/comments.php?id=2741088 Wed, 22 Jul 2009 20:16:04 +0100 2741088 http://www.medworm.com/index.php?rid=2616738&cid=t_159330_111_f&fid=36048&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FAHeartyLife%2F%7E3%2FmFTON_zX3KA%2F Here’s some exciting news for diabetics. In fact, the more I read about diabetes treatment these days, the more excited I become. A group of researchers took non-obese diabetic mice which had recently developed Type 1 diabetes, and injected them with an “anti-CD3 monoclonal antibody for five days, followed by transplantation of embryonic pancreatic tissue, and, for short-term glucose control, implantation of a subcutaneous insulin pellet.” Most of the mice maintained normal blood sugars after the removal of the insulin pellet. The transplanted cells were shown to migrate to the pancreas of the test subjects. Is this a cure for diabetes? Sorry - but no. Still, this is exciting research that tells more and more about how the body tolerates transplanted cells and tissue. Th... A Hearty Life blogs http://www.medworm.com/rss/comments.php?id=2616738 Sun, 19 Jul 2009 20:55:40 +0100 2616738 http://www.medworm.com/index.php?rid=2417147&cid=t_159330_136_f&fid=37846&url=http%3A%2F%2Fhealthinfoispower.wordpress.com%2F2009%2F05%2F18%2Fmesothelin-a-potential-new-target-for-ovarian-cancer-immunotherapy%2F Researchers have generated altered immune cells that are able to shrink, and in some cases eradicate, large tumors in mice. The immune cells target mesothelin, a protein that is highly expressed, or translated in large amounts from the mesothelin gene, on the surface of several types of cancer cells. The approach, developed by researchers at [...] (Source: Libby's H*O*P*E*) Libby's H*O*P*E* blogs http://www.medworm.com/rss/comments.php?id=2417147 Tue, 19 May 2009 04:51:22 +0100 2417147 http://www.medworm.com/index.php?rid=2365380&cid=t_159330_136_f&fid=37846&url=http%3A%2F%2Fhealthinfoispower.wordpress.com%2F2009%2F04%2F23%2Fpreclinical-results-validate-lpathomab-as-a-potential-future-treatment-for-ovarian-cancer%2F “Lpath, Inc. … , the category leader in bioactive-lipid-targeted therapeutics, reported compelling new in vivo and in vitro results relating to its preclinical drug candidate, Lpathomab, in various ovarian cancer studies …” “Lpath Presents Compelling New Preclinical Results of Its Anti-Cancer Drug Candidate, Lpathomab(TM), at the AACR 100th Annual Meeting - New In Vivo and In Vitro [...] (Source: Libby's H*O*P*E*) Libby's H*O*P*E* blogs http://www.medworm.com/rss/comments.php?id=2365380 Thu, 23 Apr 2009 23:28:32 +0100 2365380 http://www.medworm.com/index.php?rid=2349515&cid=t_159330_136_f&fid=37846&url=http%3A%2F%2Fhealthinfoispower.wordpress.com%2F2009%2F04%2F15%2Fstanford-researchers-harness-nanoparticles-to-track-cancer-cell-changes%2F “A new imaging technology could give scientists the ability to simultaneously measure as many as 100 or more distinct features in or on a single cell. In a disease such as cancer, that capability would provide a much better picture of what’s going on in individual tumor cells. A Stanford University School of Medicine team [...] (Source: Libby's H*O*P*E*) Libby's H*O*P*E* blogs http://www.medworm.com/rss/comments.php?id=2349515 Wed, 15 Apr 2009 21:38:07 +0100 2349515 http://www.medworm.com/index.php?rid=2326616&cid=t_159330_136_f&fid=37846&url=http%3A%2F%2Fhealthinfoispower.wordpress.com%2F2009%2F04%2F07%2Fcnto-328-shows-promise-for-ovarian-cancer-in-small-clinical-trial-say-uk-scientists%2F British scientists have developed and clinically tested a drug that could prolong the lives of ovarian cancer patients. A clinical trial of the drug, codenamed CNTO328, has been carried out at the Centre for Experimental Cancer Medicine, which is part of Barts and the London School of Medicine and Dentistry. … The drug is an [...] (Source: Libby's H*O*P*E*) Libby's H*O*P*E* blogs http://www.medworm.com/rss/comments.php?id=2326616 Sun, 12 Apr 2009 03:04:22 +0100 2326616 http://www.medworm.com/index.php?rid=2323808&cid=t_159330_132_f&fid=35016&url=http%3A%2F%2Fpeanutbutter.wordpress.com%2F2009%2F04%2F07%2Fhupo-psi-par-standard-format-for-protein-affinity-reagents%2F Image via Wikipedia HUPO PSI-PAR: standard format for protein affinity reagents is now available for Public Comment on the PSI Web site for the next 30 days. The public comment period enables the wider community to provide feedback on a proposed standard before it is formally accepted, and thus is an important step in the standardisation process. This message is to encourage you to contribute to the standards development activity by commenting on the material that is available online. We invite both positive and negative comments. If negative comments are being made, these could be on the relevance, clarity, correctness, appropriateness, etc, of the proposal as a whole or of specific parts of the proposal. If you do not feel well placed to comment on this document, but know someone who ... peanutbutter blogs http://www.medworm.com/rss/comments.php?id=2323808 Tue, 07 Apr 2009 08:34:35 +0100 2323808 http://www.medworm.com/index.php?rid=2115491&cid=t_159330_132_f&fid=35016&url=http%3A%2F%2Fpeanutbutter.wordpress.com%2F2009%2F01%2F19%2Fall-change-in-2009-no-more-academia%2F Image via Wikipedia Last week I completed what was my first week of working in academia in 2009 and also my last for the foreseeable future. I have decided to leave academia, as well as Newcastle to take a position in a Biotech company in Cambridge. I have certainly enjoyed just over 5 years working in Newcastle encompassing my PhD and a postdoc. Within that time my research interests have developed from representing scientific data, to data standards to ontology development. I am still maintaining some of my research interests in my new position. I will be working for an antibody company called Abcam, and as part of my role I will be investigating how to represent their product catalogue as an ontology and how users can have a more direct interaction with it. I am really looking forwar... peanutbutter blogs http://www.medworm.com/rss/comments.php?id=2115491 Mon, 19 Jan 2009 22:04:26 +0100 2115491 http://www.medworm.com/index.php?rid=2382468&cid=t_159330_107_f&fid=38577&url=http%3A%2F%2Fbiosingularity.wordpress.com%2F2008%2F10%2F24%2Fnew-hope-for-multiple-sclerosis-sufferers%2F A drug which was developed in Cambridge and initially designed to treat a form of leukaemia has also proven effective against combating the debilitating neurological disease multiple sclerosis (MS). The study, led by researchers from the University of Cambridge, has found that alemtuzumab not only stops MS from advancing in patients with early stage active relapsing-remitting [...] (Source: Biosingularity) Biosingularity blogs http://www.medworm.com/rss/comments.php?id=2382468 Fri, 24 Oct 2008 00:01:22 +0100 2382468 http://www.medworm.com/index.php?rid=1637996&cid=t_159330_136_f&fid=36051&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FCancerCommentary%2F%7E3%2F339122109%2F ImClone Systems, Inc.’s advanced colorectal cancer drug has now received regulatory approval in Japan. ERBITUX(R) (cetuximab) has received marketing authorization in Japan for use in treating patients with advanced or metastatic colorectal cancer (mCRC). Specifically, this approval allows for the use of ERBITUX to treat patients with epidermal growth factor receptor (EGFR)-positive, curatively unresectable (inoperable), advanced or recurrent CRC, and allows the use of ERBITUX plus irinotecan in second and further lines of mCRC. With this approval, ERBITUX is the first ever EGFR-targeted monoclonal antibody to be submitted for and receive marketing authorization in Japan. ERBITUX (cetuximab) is a monoclonal antibody (IgG1 Mab) designed to inhibit the function of a molecular structure ... Cancer Commentary blogs http://www.medworm.com/rss/comments.php?id=1637996 Fri, 18 Jul 2008 16:00:28 +0100 1637996 http://www.medworm.com/index.php?rid=1198675&cid=t_159330_109_f&fid=34750&url=http%3A%2F%2Fpsychcentral.com%2Fblog%2Farchives%2F2008%2F02%2F03%2Findividuals-infected-with-certain-parasite-24-more-likely-to-develop-schizophrenia%2F It has long been hypothesized that it’s unhealthy for pregnant women to change the cat litter, but now more then ever, pregnant women have a reason to hand over the pooper-scooper responsibilities. A recent study published in The American Journal of Psychiatry claims that individuals exposed to the Toxoplasma gondii parasite, which is carried by cats and farm animals, have a 24% greater risk of developing schizophrenia. The researchers that completed this study are planning further studies on whether treating the toxoplasma gondii infection can stop the progression of the schizophrenia. This parasite can be found on undercooked meat and cat feces. It is thought that the parasite can live for up to a year in a damp shaded environment. If you are pregnant or you have children already, yo... World of Psychology blogs http://www.medworm.com/rss/comments.php?id=1198675 Mon, 04 Feb 2008 00:03:41 +0100 1198675 http://www.medworm.com/index.php?rid=1068767&cid=t_159330_134_f&fid=36049&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FDiabetesNotes%2F%7E3%2F194876647%2F Yale school of Medicine, New Haven has developed the means to establish the depletion of B cells in diabetes and proven to reverse the disease that was established in mice. Pretty darn cool. Up to now scientists have been able to do this with RA, rheumatoid arthritis, but haven’t had the tools to recreate this same type of research among diabetic cells. In the study, autoimmune diabetes–susceptible mice were engineered such that their B cells expressed human CD20. Depletion of B cells in these mice before they showed signs of diabetes, using a single dose of a CD20-specific antibody, delayed and/or reduced the onset of disease. It is truly amazing how we can dissect how our bodies work and recreate different situations to enhance and further science! Share This (Source: Diabete... Diabetes Notes blogs http://www.medworm.com/rss/comments.php?id=1068767 Tue, 04 Dec 2007 10:45:06 +0100 1068767 http://www.medworm.com/index.php?rid=988523&cid=t_159330_150_f&fid=35777&url=http%3A%2F%2Ffeeds.feedburner.com%2F%7Er%2FPharmalot%2F%7E3%2F176772939%2F As the day wears on, it may be a good idea to break for a cup of, well, something or take a quick stroll to keep the circulation going. Here are a few items, meanwhile, to help you clear your head… Wyeth Recalls Cough & Cold Meds With Faulty Cups (Yahoo/Reuters) Cambridge Antibody To Change Name To MedImmune (Yahoo/AP) China Raises Standards For Drug Licensing (Yahoo/AP) Shire Launches Website For Clinical Trial Results (PharmaTimes) Share / E-mail (Source: Pharmalot) Pharmalot blogs http://www.medworm.com/rss/comments.php?id=988523 Mon, 29 Oct 2007 17:45:58 +0100 988523