MedWorm provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest medical blog items that have been tagged with 'apoe4'. Sat, 03 Sep 2011 02:58:40 +0100 http://www.medworm.com/index.php?rid=2594577&cid=t_126601_131_f&fid=34989&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FGeneticsHealth%2F%7E3%2FIg_XnGRy50A%2F A new gene that could help predict who gets Alzheimer’s and what age has been discovered by Duke University scientists, and it sits close to a gene well-known to increase the risk of the disease. The ApoE4 gene is a genetic risk factor for Alzheimer’s Disease (AD4). People who inherit the ApoE4 gene from one parent are three times more likely to develop AD, and those who carry two copies are ten times more likely to get the disease. The other allele called ApoE3 has not been implicated in developing Alzheimer’s. However,  Dr. Allen Roses, who led the group from Duke, reported that there is another gene called TOMM40 that can predict how soon a person may get Alzheimer’s if he carries the ApoE3 genotype. Apparently, Alzheimer’s can develop by an average of seven years early... Genetics and Health blogs http://www.medworm.com/rss/comments.php?id=2594577 Sun, 12 Jul 2009 06:08:00 +0100 2594577 http://www.medworm.com/index.php?rid=1492318&cid=t_126601_131_f&fid=35743&url=http%3A%2F%2Fthegenesherpa.blogspot.com%2F2008%2F06%2F14-years-and-still-no-good-genes.html I am preparing a talk for the Connecticut Geriatric Society and I am just can't get over it. We haven't found good genes for Late Onset Alzheimer's Disease since 1994. Sure we have SORL1, GALP and MAPT from the sexy Genome Wide Studies....but nothing increases risk like APOE Epsilon4.In fact when you look at all the other genetic risks, NONE top an Odds Ratio of 1.5. Why do a I always harp on Odds Ratios? It's simple. If you can't beat the family history risk increase (300-500%) for a first generation relative, then you can't have much clinical significance, unless you have a multiple gene panel that does.Why is clinical utility so important? Why not just test everyone with everything. I see several problems with this.1. False Reassurances, patients are led to believe they won't get some d... Gene Sherpas: Personalized Medicine and You blogs http://www.medworm.com/rss/comments.php?id=1492318 Wed, 04 Jun 2008 12:58:00 +0100 1492318 http://www.medworm.com/index.php?rid=958838&cid=t_126601_117_f&fid=34612&url=http%3A%2F%2Fwww.thedoctorweighsin.com%2Fjournal%2F2007%2F10%2F17%2Falzheimers-disease-is-there-daylight-at-the-end-of-the-tunne.html So let’s be honest, baby boomer, aren’t you worried about turning a geezer boomer soon? After all, the first of you just got on Social Security. And what about those memory lapses? In your heart of hearts, are’nt you scared just a little bit? If you are not—read on. Here are some sobering statistics. · More than 5 million Americans are estimated to have Alzheimer’s disease or AD today. It is projected that 14.3 million Americans will have the disease by mid-century: a 350 percent increase from 2000, when there were 4 million people with the disease. Reason for the expected explosive growth: a tidal wave of aging baby boomers turning old geezers. In the United States, AD was the 7th leading cause of death in 2004 , with 65,829 number of deaths (and risin... The Doctor Weighs In blogs http://www.medworm.com/rss/comments.php?id=958838 Wed, 17 Oct 2007 00:07:25 +0100 958838 http://www.medworm.com/index.php?rid=687112&cid=t_126601_131_f&fid=35743&url=http%3A%2F%2Fthegenesherpa.blogspot.com%2F2007%2F06%2Fwhy-watson-didnt-want-his-apoe4-results.html Alzheimer's disease (AD) afflicts about 10% of persons over 65 and almost half of those over 85. When Jim Watson had his genome sequenced he asked not to have his ApoE4 status revealed. Why?? Dr Watson did not want to know his genotype status because although twin studies suggest that there are several susceptibility genes which, along with the APOE 4 allele, contribute to up to 80% of LOAD (Late Onset Alzheimer's Disease) cases, the story is nowhere near being finished. Not everyone with APOE4 gets Alzheimer's. In fact, the majority do not......But the picture for those predisposed is getting clearer.This last week a study was released by the team at TGen (Translational Genomics) in the journal Neuron. According to the study:"...suggests that the gene - called GAB2 - modifies an individua... Gene Sherpas: Personalized Medicine and You blogs http://www.medworm.com/rss/comments.php?id=687112 Mon, 11 Jun 2007 20:55:00 +0100 687112