MedWorm provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest medical blog items that have been tagged with 'atp'. Sat, 03 Sep 2011 02:28:30 +0100 http://www.medworm.com/index.php?rid=4893640&cid=t_105307_113_f&fid=39278&url=http%3A%2F%2Fblogsite.mdbuyline.com%2F%3Fp%3D274 Each year, over 600,000 Americans suffer from a stroke, and 25% of those strokes are fatal.  Currently, the only therapy for an ischemic stroke patient is Plasminogen Activator (tPA), a drug designed to help dissolve the blood clot and restore blood flow to the brain, keeping further tissue damage from occurring.     However, transcranial laser therapy (TLT) is a two- to three-hour procedure in which infrared light is applied to 20 sites around the skull within 24 hours of the onset of a stroke.  The light is used to stimulate the production of ATP (Adenosine-5′-triphosphate) in the mitochondria, a key element for neural development and the cell survival after a stroke. Currently, two clinical trials have been performed (NEST1 and NEST 2) with a third underway.  Results of the... MD Buyline blogs http://www.medworm.com/rss/comments.php?id=4893640 Thu, 02 Jun 2011 13:39:41 +0100 4893640 http://www.medworm.com/index.php?rid=3625499&cid=t_105307_87_f&fid=39187&url=http%3A%2F%2Fgetbetterhealth.com%2Fpain-relief-study-has-potential-with-a-spin%2F2010.06.03 The development of drugs and other treatments for specific symptoms or conditions relies heavily on either serendipity (the chance finding of a beneficial effect) or on an understanding of underlying mechanisms. In pain, for example, there are limited ways in which we can block pain signals –- such as activating opiate receptors, or inhibiting prostaglandins. There are only so many ways in which you can interact with these systems. The discovery of a novel mechanism of modulating pain is therefore most welcome, and has the potential of leading to entirely new treatments that may have a better side effect profile than existing treatments and also have an additive clinical effect. A recent study by Nana Goldman et. al., published in Nature Neuroscience, adds to our understanding of pain re... Better Health blogs http://www.medworm.com/rss/comments.php?id=3625499 Thu, 03 Jun 2010 12:00:53 +0100 3625499 http://www.medworm.com/index.php?rid=2761546&cid=t_105307_77_f&fid=37259&url=http%3A%2F%2Fwww.horizonpress.com%2Fblogger%2F2009%2F09%2Fabc-conference.html February 27 - March 5, 2010 ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases Innsbruck, Austria Further information 3rd FEBS Special Meeting on ABC Proteins - ABC2010 ABC2010 will cover all basic and applied aspects of ABC proteins, both in normal and cancer cells, as well as their important roles in genetic diseases as well as drug resistance phenomena in cancer or microbial systems. Leading scientists from all over the world and representatives of major pharmaceutical companies will present and discuss latest news on ABC proteins operating in bacteria, fungi, plants, parasites and humans. We were able to commit numerous leading experts to participate, with many new faces attending as plenary speakers. Suggested reading: ABC Transporters in Microorganisms... Microbiology Blog: The weblog for microbiologists. blogs http://www.medworm.com/rss/comments.php?id=2761546 Thu, 03 Sep 2009 15:42:00 +0100 2761546 http://www.medworm.com/index.php?rid=2274434&cid=t_105307_77_f&fid=37259&url=http%3A%2F%2Fwww.horizonpress.com%2Fblogger%2F2009%2F03%2Fabc-transporters.html ABC transporters are fascinating molecular systems that catalyze the vectorial transport of a great variety of substrates across biological membranes. They constitute a large superfamily of primary active transport systems that are present in all kingdoms of life, and play a diversity of physiological roles. A prominent characteristic of these systems is that they share a highly conserved domain, the ATP binding cassette (ABC), which binds and hydrolyzes ATP. The amino acid sequence of this cassette displays three major conserved motifs: the Walker A and Walker B motifs commonly found in P-loop containing ATPases or GTPases and a specific signature motif known as the linker peptide, the ABC signature motif, or simply the C loop.The year 2006 marked the 20th anniversary of the identificatio... Microbiology Blog: The weblog for microbiologists. blogs http://www.medworm.com/rss/comments.php?id=2274434 Wed, 18 Mar 2009 11:35:00 +0100 2274434 http://www.medworm.com/index.php?rid=2259405&cid=t_105307_122_f&fid=35068&url=http%3A%2F%2Fbrainwindows.wordpress.com%2F2009%2F03%2F12%2Fbackground-perceval-the-atpadp-sensor%2F Recently, Brain Windows mentioned the report A genetically encoded fluorescent reporter of ATP:ADP ratio. We invited Dr. Jim Berg, the lead author of the study to provide additional background to our readers. Below, Jim provides a fascinating look at rationale behind sensor development.  I really like that they came at this problem with a biological question in mind, something I would recommend before anyone start the development of a genetically encoded indicator.   A pixel-by-pixel ratio of the 490 nm excitation image by the 430 nm excitation image from two cultured HEK293 cells expressing Perceval during control conditions (left) and after 40 min of metabolic inhibition with 5 mM 2-deoxyglucose (right)   Here’s a little insight into why we decided to develop a fluorescent sens... Brain Windows blogs http://www.medworm.com/rss/comments.php?id=2259405 Thu, 12 Mar 2009 19:52:55 +0100 2259405 http://www.medworm.com/index.php?rid=1643156&cid=t_105307_109_f&fid=37784&url=http%3A%2F%2Ffeeds.feedburner.com%2F%7Er%2Fpsychblog%2F%7E3%2F334938992%2Fjust-another-psychology-blog-308.html No! It’s your psychology blog! Now I’m back from the ATP Conference and recovered it’s time to announce our new project which actually formed the basis of one of the workshops we did.  Also, a big hi to all those who saw me at the conference and commented on our work on-line. Thanks :) For the past few weeks we’ve (Mark and I) have been working on a new project. Over the last year we’ve both got into blogging in a really big way - my with PsychBLOG and Mark’s PsychNews and we’ve really seen how blogging is an excellent educational tool that everyone should be able to get too. So … this got us thinking - how could we help all you avid readers get your psychology blog off the ground. We’ve come up with Psylent.co.uk. At Psylent.co.uk you... PsychBLOG.co.uk blogs http://www.medworm.com/rss/comments.php?id=1643156 Mon, 14 Jul 2008 09:06:50 +0100 1643156 http://www.medworm.com/index.php?rid=1643160&cid=t_105307_109_f&fid=37784&url=http%3A%2F%2Ffeeds.feedburner.com%2F%7Er%2Fpsychblog%2F%7E3%2F293746748%2Fone-size-fits-all-find-out-at-the-atp-conference.-386.html I’ve mentioned the ATP conference a few times before - but for the uninitiated it’s a yearly conference held by the ATP - and this year it’s in Lincoln and being organised by Phil Banyard (that chap who writes all the books and ex-Chief Examiner). The conference, this year titled ‘the wonder of psychology: inspiring teachers and learners‘, is being held between the 10th and 12th July 2008 and is for teachers of psychology offering updating sessions on psychology, presentations and workshops on teaching and learning, and opportunities to share good practice. There’s an impressive lineup of fantastic Key note speakers, those giving workshops and  stalls of people giving away loads of free stuff (well that’s what I’ve been told at least).  Mar... PsychBLOG.co.uk blogs http://www.medworm.com/rss/comments.php?id=1643160 Mon, 19 May 2008 20:30:49 +0100 1643160 http://www.medworm.com/index.php?rid=832653&cid=t_105307_134_f&fid=36049&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FDiabetesNotes%2F%7E3%2F150317128%2F Scientists have revisited the fact that certain neurons in the brain are activated by glucose. And this time they have identified that defects in the brain’s ability to respond to glucose can play a role in the development of type 2 diabetes. How is this research of clinical use you ask… “By identifying glucose-sensing neurons in the brain as important players in regulating glucose, our findings may open a new avenue of research,” Dr. Coppari said. “Because these neurons play a role in maintaining glucose homeostasis throughout the body, an impairment in their glucose-sensing ability could play a pathogenic role in type 2 diabetes, where homeostasis is altered.” In a nut shell, curb the glucose-sensing neurons into reacting appropriately and there is a d... Diabetes Notes blogs http://www.medworm.com/rss/comments.php?id=832653 Fri, 31 Aug 2007 00:42:21 +0100 832653 http://www.medworm.com/index.php?rid=487431&cid=t_105307_122_f&fid=35068&url=http%3A%2F%2Fbrainwindows.wordpress.com%2F2007%2F03%2F06%2Fatp-and-fret-a-cautionary-note-confirmed%2F In the February issue of Nature Biotechnology, a correspondence piece noted some very surprising findings regarding the sensitivity of genetically-encoded fluorescence resonance energy transfer (FRET) indicators to adenosine triphosphate. During the development of CFP-YFP based FRET reporters for adenosine nucleotides, Willemse et. al. discovered that all of their FRET constructs, including putatively non-responsive controls had a significant response to millimolar levels of ATP. Increasing levels of ATP appeared to quench the acceptor chromophore. The effect appeared specific to ATP, as 10mM ADP had no effect and 10mM GTP had a very small one. They also tested whether there was a direct effect on either the CFP or YFP and found none. Only constructs that underwent FRET showed ATP responsi... Brain Windows blogs http://www.medworm.com/rss/comments.php?id=487431 Tue, 06 Mar 2007 09:14:25 +0100 487431