MedWorm provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest medical blog items that have been tagged with 'atypical antipsychotics'. Sat, 03 Sep 2011 02:39:50 +0100 http://www.medworm.com/index.php?rid=4911818&cid=t_176257_150_f&fid=35777&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FPharmalot%2F%7E3%2F6PnSSHy9aJg%2F In explaining his decision to penalize Johnson & Johnson a healthy $327 million for deceptive marketing of its Risperdal antipsychotic, South Carolina Circuit Court Judge Roger Crouch late last week made a point of reciting a part of the famed credo that is religiously repeated by execs at the health care giant: “We believe our first responsibility is to the doctors, nurses and patients, to mothers and fathers and all others who use our products and services. In meeting their needs, everything we do must be of high quality.” Why? He wanted to contrast the credo with actions taken by the Johnson & Johnson team. To set the stage for his remarks, Crouch offered this: “It it is the loss of the company’s focus, upon the primary objective of its credo, which bri... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=4911818 Wed, 08 Jun 2011 12:08:23 +0100 4911818 http://www.medworm.com/index.php?rid=4911810&cid=t_176257_150_f&fid=34768&url=http%3A%2F%2Fpharmagossip.blogspot.com%2F2011%2F06%2Fprescribed-antipsychotics-aged-3.html Watch the full episode. See more Need To Know.Hat tip: http://seroquellawsuitblog.blogspot.com/ (Source: PharmaGossip) PharmaGossip blogs http://www.medworm.com/rss/comments.php?id=4911810 Tue, 07 Jun 2011 05:21:00 +0100 4911810 http://www.medworm.com/index.php?rid=4893907&cid=t_176257_150_f&fid=34768&url=http%3A%2F%2Fpharmagossip.blogspot.com%2F2011%2F06%2Fintroducing-seroquel-lawsuit-blog.html http://seroquellawsuitblog.blogspot.com/ (Source: PharmaGossip) PharmaGossip blogs http://www.medworm.com/rss/comments.php?id=4893907 Thu, 02 Jun 2011 04:02:00 +0100 4893907 http://www.medworm.com/index.php?rid=4876513&cid=t_176257_150_f&fid=34768&url=http%3A%2F%2Fpharmagossip.blogspot.com%2F2011%2F05%2Frisperidone-damned-with-faint-praise.html http://onlinelibrary.wiley.com/o/cochrane/clsysrev/articles/CD006918/pdf_fs.html (Source: PharmaGossip) PharmaGossip blogs http://www.medworm.com/rss/comments.php?id=4876513 Sat, 28 May 2011 05:17:00 +0100 4876513 http://www.medworm.com/index.php?rid=4803525&cid=t_176257_150_f&fid=35777&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FPharmalot%2F%7E3%2Ff59stkxE_2w%2F The unnecessary use of antipsychotics in nursing homes has been controversial for several years. Now, a report from the US Department of Health & Human Services Office of Inspector General finds that, in the six-month period from January through June 2007, 51 percent of Medicare claims for atypical antipsychotics were erroneous. This amounted to a $116 million series of mistakes. The OIG report was generated at the request of US Senator Chuck Grassley, who expressed concern that atypical antipsychotics - the newest generation of such meds - were being prescribed on an off-label basis, given that the side effects associated with the drugs include increased risk of death in elderly persons with dementia. Nursing homes are a big business for these drugs. But as the OIG notes, Medicare re... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=4803525 Mon, 09 May 2011 21:25:07 +0100 4803525 http://www.medworm.com/index.php?rid=4759025&cid=t_176257_150_f&fid=34768&url=http%3A%2F%2Fpharmagossip.blogspot.com%2F2011%2F04%2Fas-of-31-march-2011-legal-defence-costs.html Source (Source: PharmaGossip) PharmaGossip blogs http://www.medworm.com/rss/comments.php?id=4759025 Thu, 28 Apr 2011 08:01:00 +0100 4759025 http://www.medworm.com/index.php?rid=4759031&cid=t_176257_150_f&fid=34768&url=http%3A%2F%2Fpharmagossip.blogspot.com%2F2011%2F04%2Fastrazeneca-seroquel-click-to-chat-to.html Click here! (Source: PharmaGossip) PharmaGossip blogs http://www.medworm.com/rss/comments.php?id=4759031 Wed, 27 Apr 2011 15:23:00 +0100 4759031 http://www.medworm.com/index.php?rid=4464694&cid=t_176257_150_f&fid=34768&url=http%3A%2F%2Fpharmagossip.blogspot.com%2F2011%2F02%2Fwhat-were-astrazenecas-senior.html Looks like full marks fromDr John Patterson back in 2001But wait! There's more:Martin Nicklasson 2002Nigel Doran 2004Geoff Birkett 2004 (Source: PharmaGossip) PharmaGossip blogs http://www.medworm.com/rss/comments.php?id=4464694 Fri, 11 Feb 2011 23:01:00 +0100 4464694 http://www.medworm.com/index.php?rid=4309666&cid=t_176257_109_f&fid=34750&url=http%3A%2F%2Fpsychcentral.com%2Fblog%2Farchives%2F2011%2F01%2F04%2Fwhy-doctors-oversell-benefits-undersell-risks-and-side-effects%2F Virtually across the board of medicine and psychiatry, doctors will constantly and consistently oversell the benefits of a given treatment, and undersell the risks and side effects of it. This may not be as surprising when you look at some of the key factors into how medical and psychiatric treatment is learned and then conducted on patients. Why do doctors often oversell the benefits of a given treatment, and minimize the risks and side effects of it? 1. Treatment is rarely experienced first-hand. While you don’t need to undergo surgery to understand the benefits of surgery or how to do surgery, you will surely have a great appreciation to the patient’s perspective if every surgeon was required to get an appendectomy before being allowed to practice. Surgeons know, in most ca... World of Psychology blogs http://www.medworm.com/rss/comments.php?id=4309666 Tue, 04 Jan 2011 20:24:09 +0100 4309666 http://www.medworm.com/index.php?rid=4272591&cid=t_176257_150_f&fid=34768&url=http%3A%2F%2Fpharmagossip.blogspot.com%2F2010%2F12%2Fazs-brennan-speaks-pass-me-bucket-of.html Bucket storyThe Seroquel storyQuestion 1. How much did Dave Brennan know about "The Seroquel Issue" at the time?http://pharmagossip.blogspot.com/2009/10/astrazeneca-to-pay-520-million-to.htmlThe pharmaceutical company AstraZeneca said Thursday (29/Oct/09) that it had reached a $520 million agreement to settle two federal investigations and two whistle-blower lawsuits over the sale and marketing of its blockbuster psychiatric drug Seroquel.One of the investigations related to “selected physicians who participated in clinical trials involving Seroquel,” AstraZeneca disclosed in a government filing. The other case related to off-label promotion of the drug.H. Waxman's letter:http://oversight.house.gov/Documents/20070305175741-03469.pdfThe Zoladex issue:http://www.justice.gov/opa/pr/2003/J... PharmaGossip blogs http://www.medworm.com/rss/comments.php?id=4272591 Sun, 19 Dec 2010 21:14:00 +0100 4272591 http://www.medworm.com/index.php?rid=4139471&cid=t_176257_150_f&fid=34768&url=http%3A%2F%2Fpharmagossip.blogspot.com%2F2010%2F11%2Fdr-melissa-delbello-speaks-but-this.html Sen. Charles Grassley's hall of shame: The chairman of the Senate Finance Committee raised the case of Dr. Melissa DelBello, a psychiatrist who got hundreds of thousands of dollars in travel expenses, consulting fees, and lecture payments from AstraZeneca. DelBello also happened to be lead author of a study that concluded kids did well on AstraZeneca's antipsychotic med Seroquel.Here's the timeline: DelBello authored the study, published in 2002. In 2003, she got $100,000 from the drugmaker, or so she told the University of Cincinnati. In 2004, she reported $80,000. AstraZeneca's figures total $238,000.Grassley was pretty peeved not only about the apparent conflict of interest--which AstraZeneca denied; DelBello wasn't available for comment--but also by the fact that DelBello also got NIH ... PharmaGossip blogs http://www.medworm.com/rss/comments.php?id=4139471 Sat, 06 Nov 2010 04:53:00 +0100 4139471 http://www.medworm.com/index.php?rid=3662919&cid=t_176257_150_f&fid=34768&url=http%3A%2F%2Fpharmagossip.blogspot.com%2F2010%2F06%2Fstings-in-tail.html (Source: PharmaGossip) PharmaGossip blogs http://www.medworm.com/rss/comments.php?id=3662919 Tue, 15 Jun 2010 05:46:00 +0100 3662919 http://www.medworm.com/index.php?rid=3534089&cid=t_176257_150_f&fid=34768&url=http%3A%2F%2Fpharmagossip.blogspot.com%2F2010%2F05%2Futah-goes-for-j-and-astrazeneca.html http://freepdfhosting.com/4223749c08.pdfAs always Ed covers the story well. (Source: PharmaGossip) PharmaGossip blogs http://www.medworm.com/rss/comments.php?id=3534089 Wed, 05 May 2010 13:03:00 +0100 3534089 http://www.medworm.com/index.php?rid=3524454&cid=t_176257_150_f&fid=34768&url=http%3A%2F%2Fpharmagossip.blogspot.com%2F2010%2F05%2Fastrazeneca-crestor-diabetes-connection.html The statin drug Crestor, made by AstraZeneca, recently received an expanded label indication from the FDA to include patients with normal cholesterol levels. At the same time, new studies indicate that statins increase the risk of diabetes by 9%. For low-heart-risk patients, the risk-benefit analysis might not support statins. Naveed Sattar, MD PhD, author of the Lancet paper highlighting the diabetes risk, spoke with The HCC. He reviewed his findings and posed some possible biological mechanisms of action to explain how statins could causes diabetes. Other drugs, such as antipsychotics, are well known to cause diabetes. Login to view the story. Register on http://thehcc.tv/ The Healthcare Channel on http://thehcc.tv/ (Source: PharmaGossip) PharmaGossip blogs http://www.medworm.com/rss/comments.php?id=3524454 Sat, 01 May 2010 16:29:00 +0100 3524454 http://www.medworm.com/index.php?rid=3519699&cid=t_176257_150_f&fid=34768&url=http%3A%2F%2Fpharmagossip.blogspot.com%2F2010%2F04%2Fjay-byrne-v-fluence-and-astrazeneca.html Jay Byrne From SpinProfiles Jump to: navigation, search Jay Byrne is Monsanto's former Director of Public Affairs and former Internet Outreach Programs Director. Prior to Monsanto, Byrne worked for USAID. Since leaving Monsanto, Byrne has become president of Internet PR company V-Fluence[1], whose vice-president, Richard Levine, was formerly part of the Monsanto team for Monsanto's Internet PR firm Bivings Group. V-Fluence is based, like Monsanto, in St. Louis. Monsanto is one of its clients.[2] Covert Monsanto-Bivings campaign Byrne is believed to have been the chief architect of the covert Monsanto-Bivings PR campaign which involved attacks on the company's critics via front e-mails, such as those of Andura Smetacek and Mary Murphy, and material posted on the website of a fa... PharmaGossip blogs http://www.medworm.com/rss/comments.php?id=3519699 Fri, 30 Apr 2010 06:16:00 +0100 3519699 http://www.medworm.com/index.php?rid=3476076&cid=t_176257_150_f&fid=34768&url=http%3A%2F%2Fpharmagossip.blogspot.com%2F2010%2F04%2Fastrazeneca-seroquel-waynes-world.html Wayne L Pines book - in full!Insider is engrossed! (Source: PharmaGossip) PharmaGossip blogs http://www.medworm.com/rss/comments.php?id=3476076 Thu, 15 Apr 2010 18:13:00 +0100 3476076 http://www.medworm.com/index.php?rid=3468012&cid=t_176257_150_f&fid=34768&url=http%3A%2F%2Fpharmagossip.blogspot.com%2F2010%2F04%2Fastrazeneca-seroquel-reinstein-payments.html All 20 pages of them!Back story here. (Source: PharmaGossip) PharmaGossip blogs http://www.medworm.com/rss/comments.php?id=3468012 Wed, 14 Apr 2010 08:19:00 +0100 3468012 http://www.medworm.com/index.php?rid=3390987&cid=t_176257_150_f&fid=34768&url=http%3A%2F%2Fpharmagossip.blogspot.com%2F2010%2F03%2Fastrazeneca-seroquel-is-this-canadian.html "Weight change minimal and dose independent (in controlled clinical trials)"Dear oh dear! (Source: PharmaGossip) PharmaGossip blogs http://www.medworm.com/rss/comments.php?id=3390987 Sun, 21 Mar 2010 22:21:00 +0100 3390987 http://www.medworm.com/index.php?rid=3354569&cid=t_176257_150_f&fid=34768&url=http%3A%2F%2Fpharmagossip.blogspot.com%2F2010%2F03%2Fj-risperdal-did-j-plan-to-break-rules.html Documents from a lawsuit by the state of Louisiana accusing J&J of off-label marketing shed fresh light on the company's long-standing desire to broaden the market for Risperdal beyond the ailments listed initially on the label—psychotic disorders linked to schizophrenia. J&J disclosed the documents from the suit, filed in the Opelousas district court in September 2004, after Bloomberg News asked the court to unseal them. The case is scheduled to go to trial in September. As early as 1994, the filings show, the FDA ordered J&J's Janssen Pharmaceuticals unit, which developed Risperdal, to stop making false and misleading marketing claims about the drug's superiority to competing medicines. In 1999 the FDA warned J&J in a letter that its marketing materials for geriatric pa... PharmaGossip blogs http://www.medworm.com/rss/comments.php?id=3354569 Thu, 11 Mar 2010 10:14:00 +0100 3354569 http://www.medworm.com/index.php?rid=3247074&cid=t_176257_150_f&fid=34768&url=http%3A%2F%2Fpharmagossip.blogspot.com%2F2010%2F02%2Fastrazeneca-seroquel-read-full.html HereListen here (Source: PharmaGossip) PharmaGossip blogs http://www.medworm.com/rss/comments.php?id=3247074 Fri, 05 Feb 2010 21:58:00 +0100 3247074 http://www.medworm.com/index.php?rid=3223486&cid=t_176257_150_f&fid=34768&url=http%3A%2F%2Fpharmagossip.blogspot.com%2F2010%2F01%2Fdrug-marketing-is-very-sophisticated.html A FLINDERS University study has exposed "corrupt" drug company marketing practices including covering up adverse side effects and pushing patients on to new, more expensive drugs even when they are less effective. Psychiatrist Peter Parry and American colleague Glen Spielmans studied 400 internal emails and research documents unearthed mainly through court cases. "Drug marketing is a very sophisticated system which corrupts every part of the scientific and medical network," Dr Parry said. Dr Parry said one disturbing finding was that, regardless of the health benefits, drug companies were pushing patients towards their own patented drugs because they could make bigger profits. Such products were called "blockbuster drugs" in the industry because they could make more than $1 billion in p... PharmaGossip blogs http://www.medworm.com/rss/comments.php?id=3223486 Sat, 30 Jan 2010 02:44:00 +0100 3223486 http://www.medworm.com/index.php?rid=3212594&cid=t_176257_150_f&fid=34768&url=http%3A%2F%2Fpharmagossip.blogspot.com%2F2010%2F01%2Fbbc-podcasts-file-on-4.html BBC - Podcasts - File on 4 (Source: PharmaGossip) PharmaGossip blogs http://www.medworm.com/rss/comments.php?id=3212594 Wed, 27 Jan 2010 03:00:00 +0100 3212594 http://www.medworm.com/index.php?rid=3212596&cid=t_176257_150_f&fid=34768&url=http%3A%2F%2Fpharmagossip.blogspot.com%2F2010%2F01%2Fastrazeneca-seroquel-listen-to-bbc-file.html HereFile on 4 is on BBC Radio 4 on Tuesday, 26 January , at 2000 GMT, repeated Sunday, 31 January, at 1700 GMT. You can also listen via the BBC iPlayer after broadcast or download thepodcast. (Source: PharmaGossip) PharmaGossip blogs http://www.medworm.com/rss/comments.php?id=3212596 Tue, 26 Jan 2010 22:19:00 +0100 3212596 http://www.medworm.com/index.php?rid=3208677&cid=t_176257_150_f&fid=34768&url=http%3A%2F%2Fpharmagossip.blogspot.com%2F2010%2F01%2Fthis-is-must-read-marketing-based.html Contact Glen Spielmans for a copyOr access it hereAbstract: While much excitement has been generated surrounding evidence-based medicine, internal documents from the pharmaceutical industry suggest that the publicly available evidence base may not accurately represent the underlying data regarding its products. The industry and its associated medical communication firms state that publications in the medical literature primarily serve marketing interests. Suppression and spinning of negative data and ghostwriting have emerged as tools to help manage medical journal publications to best suit product sales, while disease mongering and market segmentation of physicians are also used to efficiently maximize profits. We propose that while evidence-based medicine is a noble ideal, marketing-base... PharmaGossip blogs http://www.medworm.com/rss/comments.php?id=3208677 Tue, 26 Jan 2010 14:04:00 +0100 3208677 http://www.medworm.com/index.php?rid=3194009&cid=t_176257_150_f&fid=34768&url=http%3A%2F%2Fpharmagossip.blogspot.com%2F2010%2F01%2Fthis-sounds-interesting-file-on-4.html A British drug company is being sued by more than 15,000 people in the United States who claim its bestselling antipsychotic drug caused severe weight gain, diabetes and other serious medical conditions.Ann Alexander investigates concerns about the way it was marketed and asks how much the public should be told about the drugs they take.File on 4 - SourceHmmm! I wonder which antipsychotic that might be? (Source: PharmaGossip) PharmaGossip blogs http://www.medworm.com/rss/comments.php?id=3194009 Thu, 21 Jan 2010 08:25:00 +0100 3194009 http://www.medworm.com/index.php?rid=3167449&cid=t_176257_150_f&fid=35777&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FPharmalot%2F%7E3%2F39bF0JITF2Q%2F The use of atypical antipsychotics to treat elderly patients with dementia appears to have decreased following an advisory issued in 2005 by the FDA concerning the increased risk of death, according to a report in the Archives of Internal Medicine, one of the JAMA/Archives journals. This was an off-label use, by the way. Researchers analyzed nationally representative data to assess rates of atypical antipsychotic drug use between January 2003 and December 2008. From January 2003 to March 2005, the rate of atypical drug mentions increased 34 percent per year, including a 16 percent increase among patients with dementia. In the year before the FDA advisory, approximately 13.6 million atypical antipsychotic mentions occurred, 0.8 million of which involved patients with dementia (here is the a... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=3167449 Tue, 12 Jan 2010 18:28:48 +0100 3167449 http://www.medworm.com/index.php?rid=2570607&cid=t_176257_109_f&fid=34750&url=http%3A%2F%2Fpsychcentral.com%2Fblog%2Farchives%2F2009%2F07%2F02%2Fbreakthrough-for-schizophrenia-and-bipolar%2F Earlier today, we reported that NIMH-funded researchers at three different genetic research institutes from around the world collaborated and published three new studies yesterday in the journal, Nature, that suggested a true breakthrough in our understanding of schizophrenia and bipolar disorder. And to think that just earlier this week, I was dismissing the largely inconclusive findings of genetics research in mental illness. One of the researchers commented on the findings: “There was substantial overlap in the genetic risk for schizophrenia and bipolar disorder that was specific to mental disorders. We saw no association between the suspect gene variants and half a dozen common non-psychiatric disorders.” This is an important discovery — that some of the roots of schi... World of Psychology blogs http://www.medworm.com/rss/comments.php?id=2570607 Thu, 02 Jul 2009 19:00:34 +0100 2570607 http://www.medworm.com/index.php?rid=2473571&cid=t_176257_109_f&fid=34750&url=http%3A%2F%2Fpsychcentral.com%2Fblog%2Farchives%2F2009%2F06%2F12%2F9-myths-of-bipolar-disorder%2F Bipolar disorder has been the focus of attention in recent years, as a new slew of psychiatric medications have been developed to help treat it. Such medications drive pharmaceutical marketing and increased educational efforts surrounding bipolar disorder (for better or worse). But many myths surround bipolar disorder — what it is, what it means, and how it’s treated. Here’s to busting a few of the most common ones. 1. Bipolar disorder means I’m really “crazy.” While bipolar disorder is a serious mental disorder, it is no more serious than most other mental disorders. Having a mental disorder doesn’t mean you’re “crazy,” it just means you have a concern that is negatively impacting how you live your life. Left unaddressed, this co... World of Psychology blogs http://www.medworm.com/rss/comments.php?id=2473571 Fri, 12 Jun 2009 13:11:46 +0100 2473571 http://www.medworm.com/index.php?rid=2398818&cid=t_176257_109_f&fid=34750&url=http%3A%2F%2Fpsychcentral.com%2Fblog%2Farchives%2F2009%2F05%2F07%2Fsurprise-approval-of-fanapt-makes-stock-go-wild%2F Shares of Vanda Pharmaceuticals, the makers of Fanapt (iloperidone), surged today after the U.S. Food and Drug Administration sprang a surprise drug approval for Fanapt for schizophrenia late yesterday. In afternoon trading today, the stock hit $10.00 a share, over 8 times what the stock was trading just a day earlier. It fell back to trading around $7.54 - $7.95 range at this time. The drug has a better safety profile in clinical trials than other atypical antipsychotics, which some analysts believe will help boost prescriptions when it goes on the market this summer. Of course, the safety profile may be overly optimistic, as it was for other atypical antipsychotics before they hit the market and reality set in (e.g., use on a more diverse population). Certainly the company could’ve... World of Psychology blogs http://www.medworm.com/rss/comments.php?id=2398818 Thu, 07 May 2009 19:58:34 +0100 2398818 http://www.medworm.com/index.php?rid=2389934&cid=t_176257_109_f&fid=34750&url=http%3A%2F%2Fpsychcentral.com%2Fblog%2Farchives%2F2009%2F05%2F05%2Fmore-drugs-prescribed-but-seniors-prescriptions-double%2F News out today shows that psychiatric prescriptions have risen 73 percent in adults and 50 percent for children in the 1996 to 2006 time period. Seniors’ prescriptions for medications such as antidepressants and atypical antipsychotics during the same time period doubled (something that USA Today strangely terms as a “spike,” despite it occurring over a decade). The problem with this data is that we really don’t have much to compare it to. Is a 7 percent annual increase in psychiatric prescriptions over a 10 year time period indicative of over-prescribing and effective pharmaceutical marketing? Or would we expect a similar increase no matter what? (Sadly, no researchers track “prescriptions” of psychotherapy, so we don’t even have other treatment m... World of Psychology blogs http://www.medworm.com/rss/comments.php?id=2389934 Tue, 05 May 2009 14:24:03 +0100 2389934 http://www.medworm.com/index.php?rid=2387228&cid=t_176257_150_f&fid=34768&url=http%3A%2F%2Fpharmagossip.blogspot.com%2F2009%2F05%2Fhow-many-seroquel-lawsuits-will-there.html Jim Edwards is keeping a running total. (Source: PharmaGossip) PharmaGossip blogs http://www.medworm.com/rss/comments.php?id=2387228 Mon, 04 May 2009 08:11:00 +0100 2387228 http://www.medworm.com/index.php?rid=2376826&cid=t_176257_150_f&fid=34768&url=http%3A%2F%2Fpharmagossip.blogspot.com%2F2009%2F04%2Fwe-have-optimism-based-i-think-on.html Among all patients taking the new generation of antipsychotic medication, children are most likely to suffer severe weight gain and metabolic disturbances.But the use of these drugs to treat children has seen steep growth. Between 1990 and 2000, prescriptions for children and adolescents grew 160 percent, according to a 2005 study; other studies show they continued to grow briskly through the early 2000s.Virtually all of that prescribing has been off-label. Among the atypical antipsychotics, only risperidone (marketed as Risperdal) has been approved by the Food and Drug Administration for use by children with schizophrenia. In June, the FDA will consider a petition by AstraZeneca for permission to promote the use of Seroquel by adolescents (ages 13 to 17) with schizophrenia and by younger ... PharmaGossip blogs http://www.medworm.com/rss/comments.php?id=2376826 Tue, 28 Apr 2009 23:29:00 +0100 2376826 http://www.medworm.com/index.php?rid=2368702&cid=t_176257_150_f&fid=34768&url=http%3A%2F%2Fpharmagossip.blogspot.com%2F2009%2F04%2Fi-kid-you-not.html StoryHat tip: Furious Seasons (Source: PharmaGossip) PharmaGossip blogs http://www.medworm.com/rss/comments.php?id=2368702 Sat, 25 Apr 2009 14:11:00 +0100 2368702 http://www.medworm.com/index.php?rid=2147556&cid=t_176257_150_f&fid=34768&url=http%3A%2F%2Fpharmagossip.blogspot.com%2F2009%2F01%2Fit-was-very-clever-sort-of-con.html "Almost the whole scientific community was conned into thinking — as a consequence of good marketing — that this was a different and better set of drugs. The evidence, as it's all added up, has shown this to be untrue." Dr. Peter Tyrer, a leading psychiatric researcher at Imperial College London"We have been paying $16 billion a year instead of $2 billion a year for drugs that seem to be no better and might be worse." Douglas Leslie, a researcher at the Medical University of South CarolinaRead the article (Source: PharmaGossip) PharmaGossip blogs http://www.medworm.com/rss/comments.php?id=2147556 Sat, 31 Jan 2009 02:28:00 +0100 2147556 http://www.medworm.com/index.php?rid=2018097&cid=t_176257_150_f&fid=35777&url=http%3A%2F%2Ffeeds.feedburner.com%2F%7Er%2FPharmalot%2F%7E3%2F475704352%2F The common distinction between first- and second-generation antipsychotics has no scientific basis and should be dropped, according to a paper in The Lancet. A meta-analysis of 150 double-blind studies found little evidence that newer, so-called atypical antipsychotics are more effective than older drugs for symptoms of schizophrenia, MedPage Today writes. The researchers also found that, although newer drugs induced fewer extrapyramidal effects (including tremor, slurred speech, restlessness, movement disorders, among other things) than Haldol, which is also known as haloperidol, this did not occur when compared with low-potency first-generation agents. “Second-generation antipsychotic drugs differ in many properties” - including structure and mode of action as well as clinica... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=2018097 Fri, 05 Dec 2008 13:59:21 +0100 2018097 http://www.medworm.com/index.php?rid=2018099&cid=t_176257_150_f&fid=35777&url=http%3A%2F%2Ffeeds.feedburner.com%2F%7Er%2FPharmalot%2F%7E3%2F475652570%2F The drugmaker was aware that its antipsychotic causes diabetes as far back as 2000, according to documents filed yesterday in a federal court in Tampa, Florida, Bloomberg News reports. For instance, Wayne Geller, AstraZeneca’s global safety officer, concluded there was “reasonable evidence to suggest Seroquel therapy can cause” diabetes and related conditions, and he drew his conclusions after reviewing studies and internal trials, the documents show. The internal documents were shown publicly for the first time during a hearing over the qualifications of expert witnesses who would testify on behalf of plaintiffs at a trial set to begin in February 2 based on a lawsuit filed by Linda Guinn of Palm Bay, Florida. Only portions of the documents were shown in court, the filings rema... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=2018099 Fri, 05 Dec 2008 12:36:27 +0100 2018099 http://www.medworm.com/index.php?rid=1984811&cid=t_176257_109_f&fid=34750&url=http%3A%2F%2Fpsychcentral.com%2Fblog%2Farchives%2F2008%2F11%2F24%2Fjj-allegedly-funded-positive-research%2F The trickle of incriminating evidence against Dr. Joseph Biederman, a Harvard world-renowned child psychiatrist known for his advocacy of “pediatric bipolar disorder,” has turned into a torrent — of emails and internal documents. The New York Times reports, based upon the release of court documents containing internal documents and emails, that Dr. Biederman was allegedly paid by Johnson & Johnson (J&J) for his promotion of pediatric bipolar disorder and research into showing the efficacy of a drug used to treat it, Risperdal. Lots of good reporting on this today, so let’s start with The Philadelphia Inquirer’s take: Johnson & Johnson gave hundreds of thousands of dollars to a research center run by an influential child psychiatrist explici... World of Psychology blogs http://www.medworm.com/rss/comments.php?id=1984811 Tue, 25 Nov 2008 04:15:53 +0100 1984811 http://www.medworm.com/index.php?rid=1802938&cid=t_176257_150_f&fid=35777&url=http%3A%2F%2Ffeeds.feedburner.com%2F%7Er%2FPharmalot%2F%7E3%2F394153449%2F A new study in the American Journal of Psychiatry found that Lilly’s Zyprexa and Johnson & Johnson’s Risperdal caused more side effects and were less effective for kids with schizophrenia than a 30-year-old generic pill that costs about one-fourth of the widely marketed atypical antipsychotics (back story). Will the results change treatment practices? This remains to be seen, of course, but prescriptions have been climbing for the atypicals for years, as docs use the drugs to treat any number of behaviors and conditions - even unapproved uses, such as ADHD - despite serious side effects. The chart, courtesy of Medco Health Solutions, illustrates recent prescribing trends - the use of all antipsychotics among children soared between 2001 and 2007. For kids younger than nine years o... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=1802938 Tue, 16 Sep 2008 12:24:41 +0100 1802938 http://www.medworm.com/index.php?rid=1798527&cid=t_176257_150_f&fid=35777&url=http%3A%2F%2Ffeeds.feedburner.com%2F%7Er%2FPharmalot%2F%7E3%2F393152896%2F A new study in the American Journal of Psychiatry found that Lilly’s Zyprexa and Johnson & Johnson’s Risperdal caused more side effects and were less effective for children with schizophrenia than a 30-year-old generic pill that costs about one-fourth of the widely marketed atypical antipsychotics, according to Bloomberg News. About half of the children and teenagers taking molindone experienced fewer symptoms, compared with 46 percent of those taking Risperdal and 34 percent of those taking Zyprexa, the study found. Zyprexa costs $215 for the lowest dose used in the study, Risperdal is priced at $123 and molindone is $56, according to Drugstore.com, Bloomberg writes. Most children failed to improve on any of the drugs, but side effects were more common in those taking the... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=1798527 Mon, 15 Sep 2008 12:13:27 +0100 1798527 http://www.medworm.com/index.php?rid=1531138&cid=t_176257_87_f&fid=34595&url=http%3A%2F%2Fnhsblogdoc.blogspot.com%2F2008%2F06%2Flooking-after-patients-with-dementia-4.html The Visual Dictionary of the Human Body, Dorling Kindersley, 1991Carrying on about the dementia saga, the plot thickens. I see that the government’s “new” dementia strategy includes plans to assign every patient with dementia a ‘dementia care advisor' who can be their single contact throughout diagnosis and treatment.The care advisor could bea GP a nurse or even a charity worker.Healthcare RepublicWide range of skills there. This is an incredible attack on the role of the family doctor who has hitherto fulfilled that role for all his patients. I can’t wait for the phone calls from the “concerned” charity worker who, having just read the Dorling Kindersley "PoP Up Book of Dements", wants to suggest a change in medication.Health minister Ivan Lewis said that the strategy woul... NHS Blog Doctor blogs http://www.medworm.com/rss/comments.php?id=1531138 Fri, 20 Jun 2008 18:45:00 +0100 1531138 http://www.medworm.com/index.php?rid=1522436&cid=t_176257_150_f&fid=35777&url=http%3A%2F%2Ffeeds.feedburner.com%2F%7Er%2FPharmalot%2F%7E3%2F313254592%2F The agency is requiring manufacturers of “conventional” antipsychotic drugs to change the labeling to warn about an increased risk of death associated with the off-label use to treat behavioral problems in older people with dementia. In 2005, the FDA announced similar labeling changes for “atypical” antipsychotic drugs. At that time, Black Box warnings were added, and will now be added to the older “conventional” antipsychotics. The warning for both classes of drugs will say that clinical studies indicate that antipsychotic drugs of both types are associated with an increased risk of death when used in elderly patients treated for dementia-related psychosis, according to an FDA statement. Both classes of drugs are dopamine receptor antagonists work by blocking the action of na... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=1522436 Mon, 16 Jun 2008 19:47:12 +0100 1522436 http://www.medworm.com/index.php?rid=1370872&cid=t_176257_150_f&fid=35777&url=http%3A%2F%2Ffeeds.feedburner.com%2F%7Er%2FPharmalot%2F%7E3%2F269961795%2F Four years ago, Lilly and several other drugmakers proposed the creation of The Florida Behavioral Health Collaborative. And they provided $10 million to the state to get it up and running. Soon, an expert panel was convened and recommended state standards, and national scholars with financial ties to drugmakers that sell atypicals were invited to participate, according to The Tampa Bay Tribune. To treat schizophrenia, the panel decided docs should first try an atypical - a newer generation of meds that includes Risperdal, Seroquel, Zyprexa, Geodon and Abilify. If that didn’t work, they should try a different atypical. If that still didn’t work, they should try a third atypical or one of the older generation drugs, the paper writes. A Lilly spokeswoman tells the paper the goal... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=1370872 Mon, 14 Apr 2008 11:49:01 +0100 1370872 http://www.medworm.com/index.php?rid=1347338&cid=t_176257_109_f&fid=34750&url=http%3A%2F%2Fpsychcentral.com%2Fblog%2Farchives%2F2008%2F04%2F03%2Fprior-authorization-the-bane-of-doctors%2F Ahh, prior authorization. Those sweet, seductive words that insurance companies lull themselves to sleep at night with dollar signs jumping over a fence in a pasture. “Prior authorization” means that a doctor can’t prescribe a particular medication (or type of medication) without — you guessed it! — prior authorization from the insurance company. This usually means paperwork, phone calls, and hassle. More hassle than most docs want to bother with unless they really believe the medication is necessary for the continued health and well being of their patient. Insurance companies know this, of course, and so place some of the most expensive medications on the list that requires “prior authorization” to keep their costs low. Well, that’s the t... World of Psychology blogs http://www.medworm.com/rss/comments.php?id=1347338 Thu, 03 Apr 2008 13:55:25 +0100 1347338 http://www.medworm.com/index.php?rid=1340920&cid=t_176257_150_f&fid=35777&url=http%3A%2F%2Ffeeds.feedburner.com%2F%7Er%2FPharmalot%2F%7E3%2F261932598%2F As many as 60 percent of Alzheimer’s patients in nursing homes are given antipsychotics - both older neuroleptics and atypicals - to control behavior. But a study has found that the older meds provided no benefit for patients with mild behavioural problems and were associated with a marked deterioration in verbal skills. The research focused on 165 people with advanced Alzheimer’s who live in nursing homes in UK cities, The BBC reports. The researchers, from Kings College London and the Universities of Oxford and Newcastle, found the drugs offered no long-term benefit for most patients with mild symptoms of disturbed behavior. But just six months of treatment was enough for patients to show a marked deterioration in verbal fluency. Further preliminary analysis already under wa... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=1340920 Tue, 01 Apr 2008 12:34:01 +0100 1340920