MedWorm provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest medical blog items that have been tagged with 'binding'. Sat, 03 Sep 2011 02:25:32 +0100 http://www.medworm.com/index.php?rid=5028158&cid=t_282481_87_f&fid=36438&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FCato-at-liberty%2F%7E3%2F1bQcSKcql2Y%2F By Walter OlsonThe New York Times has an article today on the plight of Central Falls, Rhode Island, a 19,000-population industrial city that may declare bankruptcy under the fiscal weight of $80 million in pension obligations for police and fire officers. Unlike some coverage of municipal fiscal woes, this one does not dance around the way some of the problem originates in misguided labor policy: The city, just north of Providence, is small and poor, but over the years it has promised police officers and firefighters retirement benefits like those offered in big, rich states like California and New York. These uniformed workers can retire after just 20 years of service, receive free health care in retirement, and qualify for full disability pensions when only partly disabled. “Promi... Cato-at-liberty blogs http://www.medworm.com/rss/comments.php?id=5028158 Tue, 12 Jul 2011 20:27:20 +0100 5028158 http://www.medworm.com/index.php?rid=3935736&cid=t_282481_139_f&fid=38879&url=http%3A%2F%2Fmedia.rawvoice.com%2Fpmn_twiv%2Fwww.twiv.tv%2FTWiV097.mp3 Hosts: Vincent Racaniello, Peter Sarnow, and Bert Semler On episode #97 of the podcast This Week in Virology, Vincent visited Peter Sarnow and Bert Semler during a trip to California, and spoke with them about their work on internal ribosome entry, and the requirement for a cellular microRNA for hepatitis C virus replication. Download TWiV #97 (66 MB .mp3, 91 minutes) Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio. Links for this episode: Eukaryotic mRNAs that might contain an IRES (PNAS) Modulation of HCV RNA abundance by a liver-specific microRNA (Science) Viral small RNAs (PLoS Pathogens) Bridging IRES elements to the translation apparatus (Biochim Biophys Acta) A nucleo-cytoplasmic SR pro... virology blog blogs http://www.medworm.com/rss/comments.php?id=3935736 Sun, 05 Sep 2010 22:18:41 +0100 3935736 http://www.medworm.com/index.php?rid=2886211&cid=t_282481_77_f&fid=37259&url=http%3A%2F%2Fwww.horizonpress.com%2Fblogger%2F2009%2F10%2Fns1-protein-of-influenza-viruses-is.html The NS1 protein of influenza A viruses is a small (230-237-amino acid), multi-functional dimeric protein that participates in both protein-RNA and protein-protein interactions. It is comprised of two functional domains: N-terminal (amino acids 1-73) RNA-binding domain; and C-terminal (amino acids 74-230/237) effector domain. Here we focus on several of the best-characterized functional interactions of the NS1 protein. A major role of the NS1 protein is to counter host cell antiviral responses. Thus, the RNA-binding domain binds double-stranded (ds) RNA, thereby inhibiting the dsRNA activation of the antiviral oligo A synthetase/RNase L pathway that is induced by interferon-α/β (IFN-α/β). A region of the effector domain binds the protein kinase PKR, thereby preventing ... Microbiology Blog: The weblog for microbiologists. blogs http://www.medworm.com/rss/comments.php?id=2886211 Mon, 12 Oct 2009 15:31:00 +0100 2886211 http://www.medworm.com/index.php?rid=3016943&cid=t_282481_139_f&fid=38879&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FVirologyBlog%2F%7E3%2FLCpPTwJRsoY%2F The classical complement pathway begins when the initiator protein C1q binds directly to the surface of a pathogen, or to an antibody that is bound to a microbe. There is a binding site for C1q on the Fc portion of antibody molecules. C1q can also recognize molecular patterns characteristic of pathogens, much like the Toll-like receptors. C1q binding to antibody or a pathogen surface initiates an unusual protease cascade with one or more members of a set of seven activating enzymes. This set of cleavages, which occurs on the surface of the microbe, leads to the formation of the membrane attack complex that produces holes in membranes of cells and viruses. Other products of the cascade include mediators of inflammation, which recruit white blood cells to the site of infection. Still mor... virology blog blogs http://www.medworm.com/rss/comments.php?id=3016943 Fri, 02 Oct 2009 02:37:04 +0100 3016943 http://www.medworm.com/index.php?rid=2785966&cid=t_282481_107_f&fid=36698&url=http%3A%2F%2Fminingdrugs.blogspot.com%2F2009%2F09%2F50-million-chemicals-and-accelerating.html (via NatureNews) As reported by the Chemical Abstract Service (CAS) have they reached 50 million registered chemical entities.Here some numbers to think aboutCAS needed 33 years for registering the first 10 million compounds, that is one new compound every 101.5 seconds.the last 9 months CAS registered 10 million compounds, in other words, every 2.3 seconds a new compound was created !So, chemistry has improved its efficiency 44 times !This resulted in a drastically increasing patenting rate as mentioned by David Bradley. O.k. what happens now to your actual lead structure series? Don't panic! Just get enough money for mining CAS directly ... mmmh ... just kidding.Second choice? Extract all 50 million structures from PDF patents, which is really difficult and noisy, I mean it.Third choice?... Mining Drug Space blogs http://www.medworm.com/rss/comments.php?id=2785966 Thu, 10 Sep 2009 19:07:00 +0100 2785966 http://www.medworm.com/index.php?rid=2611011&cid=t_282481_111_f&fid=36048&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FAHeartyLife%2F%7E3%2FxPwodQpjcCQ%2F Women can be their own worst enemy sometimes. The fashions that we put up with can cause pain and even disfigurement if we’re slaves to certain fads. We don’t have to look too far back to learn about women who were disfigured in the name of beauty. For hundreds of years, the practice of foot binding was common place in China. The idea was to bind the feet of young girls to form them into tiny, more desirable feet. The practice only ended in the early 1900s. Although not as dramatic as foot binding, we can’t say that we don’t do harmful things to our bodies anymore, all in the name of beauty. Just look at the precarious high heels that many women wear that are known to cause problems like hammertoes and bunions. Believe it or not though, it’s not just shoes. Do... A Hearty Life blogs http://www.medworm.com/rss/comments.php?id=2611011 Thu, 16 Jul 2009 13:30:29 +0100 2611011 http://www.medworm.com/index.php?rid=2441218&cid=t_282481_87_f&fid=35052&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FWomensBioethicsBlog%2F%7E5%2FuRq1BbcEoFE%2FEaglemanetalTimeJNeuro2005.pdf That's not how the song goes, but according to a recent NPR podcast, a recent neuroscience study shows that short people actually may experience things more quickly than tall people. Really, it's more an experiment about the subjective nature of time than about tall vs. short -- from the same neuroscientist who brought us the Possibilitarian movement, Dr. David Eagleman combines psychophysical, behavioral, and computational approaches to understand the neural mechanisms of time perception. For example, touch your nose and toe at the same time. (Humor me, will you?) ... Did you feel the touch at the same time? I did. But if you think about it, shouldn't the signal from the toe take a tiny bit longer longer to get to your brain? After all, your nose is on your face, which is closer to your b... Women's Bioethics Blog blogs http://www.medworm.com/rss/comments.php?id=2441218 Tue, 26 May 2009 19:11:42 +0100 2441218 http://www.medworm.com/index.php?rid=2274434&cid=t_282481_77_f&fid=37259&url=http%3A%2F%2Fwww.horizonpress.com%2Fblogger%2F2009%2F03%2Fabc-transporters.html ABC transporters are fascinating molecular systems that catalyze the vectorial transport of a great variety of substrates across biological membranes. They constitute a large superfamily of primary active transport systems that are present in all kingdoms of life, and play a diversity of physiological roles. A prominent characteristic of these systems is that they share a highly conserved domain, the ATP binding cassette (ABC), which binds and hydrolyzes ATP. The amino acid sequence of this cassette displays three major conserved motifs: the Walker A and Walker B motifs commonly found in P-loop containing ATPases or GTPases and a specific signature motif known as the linker peptide, the ABC signature motif, or simply the C loop.The year 2006 marked the 20th anniversary of the identificatio... Microbiology Blog: The weblog for microbiologists. blogs http://www.medworm.com/rss/comments.php?id=2274434 Wed, 18 Mar 2009 11:35:00 +0100 2274434 http://www.medworm.com/index.php?rid=1049082&cid=t_282481_134_f&fid=36049&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FDiabetesNotes%2F%7E3%2F190390259%2F Glucose and fructose are metabolized in the liver. When there’s too much sugar in the diet, the liver converts it to lipid. Using a mouse model and human liver cell cultures, the scientists discovered that the increased production of lipid shut down a gene called SHBG (sex hormone binding globulin), reducing the amount of SHBG protein in the blood. SHBG protein plays a key role in controlling the amount of testosterone and estrogen that’s available throughout the body. This would indicate that the bodies liver metabolism is all “out of whack” before there are even disease symptoms and we could in turn use SHGB as a bio-marker for liver function. Pretty good idea, huh? Less SHGB protein means more testosterone and estrogen released in the body and an increased risk for infer... Diabetes Notes blogs http://www.medworm.com/rss/comments.php?id=1049082 Sun, 25 Nov 2007 21:30:42 +0100 1049082 http://www.medworm.com/index.php?rid=486274&cid=t_282481_107_f&fid=35025&url=http%3A%2F%2Frrresearch.blogspot.com%2F2007%2F02%2Fwhy-is-h-influenzaes-crp-so-feeble.html One discovery from the grad student's work on Sxy and CRP is that the H. influenzae CRP protein binds CRP sites much less strongly (with much lower affinity) than the E. coli CRP protein does. This is a bit surprising. The two proteins have quite similar sequences, and all the amino acid residues expected to directly contact the DNA are identical. He's going to contact a lab that has done extensive structural analysis of E. coli CRP, to see how difficult it would be to see how well H. influenzae CRP will superimpose on the E. coli structure. One possibility he suggested is that the dimerization domain of H. influenzae CRP could be weak. This would cause the protein to spend less time assembled into the dimers that most readily bind DNA.Until now we (at least I) had thought that the affinit... RRResearch blogs http://www.medworm.com/rss/comments.php?id=486274 Fri, 09 Feb 2007 01:57:00 +0100 486274