MedWorm provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest medical blog items that have been tagged with 'brca2'. Sat, 03 Sep 2011 02:08:45 +0100 http://www.medworm.com/index.php?rid=5103482&cid=t_103647_136_f&fid=37846&url=http%3A%2F%2Fhealthinfoispower.wordpress.com%2F2011%2F08%2F05%2Fin-depth-review-the-cancer-genome-atlas-reports-on-landmark-analysis-of-high-grade-serous-ovarian-cancer%2F An analysis of genomic changes in high grade serous ovarian cancer provides the most comprehensive and integrated view of cancer genes for any cancer type to date. Ovarian serous adenocarcinoma tumors from 489 patients were examined by The Cancer Genome Atlas (TCGA) Research Network and its analyses are reported in the June 30, 2011 issue [...] (Source: Libby's H*O*P*E*) Libby's H*O*P*E* blogs http://www.medworm.com/rss/comments.php?id=5103482 Sat, 06 Aug 2011 00:24:26 +0100 5103482 http://www.medworm.com/index.php?rid=4159429&cid=t_103647_136_f&fid=37846&url=http%3A%2F%2Fhealthinfoispower.wordpress.com%2F2010%2F11%2F11%2Fnew-assay-test-predicts-that-50-of-ovarian-cancers-will-respond-to-in-vitro-parp-inhibition%2F U.K. researchers develop a new test that could be used to select ovarian cancer patients who will benefit from a new class of drugs called “PARP inhibitors.” U.K. researchers have developed a new test that could be used to select which patients with ovarian cancer will benefit from a new class of drugs called “PARP [...] (Source: Libby's H*O*P*E*) Libby's H*O*P*E* blogs http://www.medworm.com/rss/comments.php?id=4159429 Fri, 12 Nov 2010 00:19:19 +0100 4159429 http://www.medworm.com/index.php?rid=4125281&cid=t_103647_150_f&fid=35777&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FPharmalot%2F%7E3%2FDM-zpZVqQwk%2F In a surprising move, the US Justice Department late last week filed a brief indicating the federal government does not support issuing patents on human genes by arguing these are part of nature. The friend-of-the-court filing was made in a closely watched lawsuit over patents held by Myriad Genetics on two genes - BRCA1 and BRCA2 - that are linked to an increased risk of breast and ovarian cancer. Last year, the American Civil Liberties Union and the Public Patent Foundation sued Myriad, the University of Utah Research Foundation and the US Patent & Trademark Office. They charged that Myriad’s refusal to license its patents broadly meant that women who fear they may be at risk of breast or ovarian cancers are prevented from having anyone but Myriad look at the genes in question. Ea... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=4125281 Mon, 01 Nov 2010 13:59:35 +0100 4125281 http://www.medworm.com/index.php?rid=3938295&cid=t_103647_83_f&fid=34856&url=http%3A%2F%2Finsidesurgery.com%2F2010%2F09%2Fprophylactic-mastectomy-shows-survival-benefit-brca1-brca2-patients%2F A new study published in the Journal of the American Medical Association suggests that prophylactic mastectomy and or ovariectomy confers a significant survival advantage in women with the BRCA1 and BRCA2 genetic mutations that predispose them to developing breast and ovarian cancer. The senior author was Dr. Timonthy Rebbeck of the University of Pennsylvania. (Source: Inside Surgery) Inside Surgery blogs http://www.medworm.com/rss/comments.php?id=3938295 Mon, 06 Sep 2010 19:56:53 +0100 3938295 http://www.medworm.com/index.php?rid=3802551&cid=t_103647_136_f&fid=37846&url=http%3A%2F%2Fhealthinfoispower.wordpress.com%2F2010%2F07%2F29%2Fresearchers-identify-missing-link-underlying-dna-repair-platinum-drug-resistance%2F Researchers have discovered an enzyme crucial to a type of DNA repair that also causes resistance to a class of cancer drugs most commonly used against ovarian cancer. Scientists from The University of Texas MD Anderson Cancer Center and the Life Sciences Institute of Zhejiang University in China report the discovery of the enzyme and [...] (Source: Libby's H*O*P*E*) Libby's H*O*P*E* blogs http://www.medworm.com/rss/comments.php?id=3802551 Fri, 30 Jul 2010 04:45:58 +0100 3802551 http://www.medworm.com/index.php?rid=3790886&cid=t_103647_136_f&fid=37846&url=http%3A%2F%2Fhealthinfoispower.wordpress.com%2F2010%2F07%2F26%2Fyale-identifies-kras-gene-variant-in-ovarian-cancer-patients-with-non-brca-family-history-of-breastovarian-cancer%2F A team of Yale researchers have identified a genetic marker that can help predict the risk of developing ovarian cancer, a hard to detect and often deadly form of cancer. A team of Yale researchers have identified a genetic marker that can help predict the risk of developing ovarian cancer, a hard to detect and [...] (Source: Libby's H*O*P*E*) Libby's H*O*P*E* blogs http://www.medworm.com/rss/comments.php?id=3790886 Tue, 27 Jul 2010 05:00:00 +0100 3790886 http://www.medworm.com/index.php?rid=3761592&cid=t_103647_136_f&fid=36032&url=http%3A%2F%2Fwww.everydayhealth.com%2Fblog%2Flife-with-breast-cancer%2Fhair-paste-for-chemo-hair%2F Yesterday I went to the salon to get my hair done for a family wedding this weekend. It reminded me that when I was at the BRCA conference earlier this summer in Toronto, I sat beside a woman whose hair had just begun to grow back — it was barely three-fourths of an inch long. She lamented that she had a wedding to go to that coming weekend and had no idea how she was going to look good with the limited amount of hair she had to work with. I recommended that she try using a hair product that my hairstylist recommended and showed me how to use when my hair began growing back. It’s a fun product called hair paste. When hair starts growing back, it isn’t quite the hairdo we were dreaming about during chemotherapy. My hair was curly and looked like I had four tufted patches on my... Life with Breast Cancer blogs http://www.medworm.com/rss/comments.php?id=3761592 Fri, 16 Jul 2010 16:03:59 +0100 3761592 http://www.medworm.com/index.php?rid=3754035&cid=t_103647_136_f&fid=36032&url=http%3A%2F%2Fwww.everydayhealth.com%2Fblog%2Flife-with-breast-cancer%2Fis-cancer-gone-or-just-waiting-to-get-me%2F Every now and then I struggle with the question of whether cancer will come back or if it is hiding inside of me and is just looking for an opportunity to plant its ugly, insidious self in some organ. I don’t understand if the cancer went away or if it is just dormant. When it comes to breast cancer no one likes to tell you that you are cured, and when the word remission is used it just sounds like the cancer has gone into hiding. Like most breast cancer survivors, I say things like “I had cancer,” or “I don’t have breast cancer anymore,” but this doesn’t speak to the actual status of cancer in my body. Some experts like to say that we all have cancer cells in our bodies — it is just a matter of whether it develops or not. I tested positive for the BRCA... Life with Breast Cancer blogs http://www.medworm.com/rss/comments.php?id=3754035 Wed, 14 Jul 2010 18:50:38 +0100 3754035 http://www.medworm.com/index.php?rid=3641325&cid=t_103647_150_f&fid=35777&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FPharmalot%2F%7E3%2Fjh8svxjHFBA%2F Nice to see you again. Another shiny day here on the Pharmalot corporate campus. As usual, we are hustling the short people off to the schoolhouse. And yes, to cope we are downing the mandatory cup of stimulation. How will you cope today? Perhaps getting started with the news of the world. Here, in fact, are a few items. Have a great day, everyone… Genzyme Nominates Former Amgen Exec To Its Board (Reuters) Glaxo May Slash Hundreds Of Jobs In Ireland (The Irish Examiner) Merck KGgA Reapplies With FDA For MS Pill (Reuters) Australia To Review Breast Cancer Gene Patent (The Age) Otsuka Pharma To Buy 1,300 iPads For Sales Reps (Bloomberg News) Cheap Gout Drug Can Help With Angina Pain (Reuters) MS Pill Risk-Sharing Plan Is A Costly Failure To NHS (PharmaTimes) (Source: Pharmalot) Pharmalot blogs http://www.medworm.com/rss/comments.php?id=3641325 Tue, 08 Jun 2010 11:50:44 +0100 3641325 http://www.medworm.com/index.php?rid=3501683&cid=t_103647_136_f&fid=37846&url=http%3A%2F%2Fhealthinfoispower.wordpress.com%2F2010%2F04%2F23%2Fparp-inhibitor-olaparib-benefits-women-with-inherited-ovarian-cancer-based-upon-platinum-drug-sensitivity%2F Olaparib (AZD2281), a new type of cancer drug known as a “PARP inhibitor,” produced promising results in patients with platinum-refractory, platinum-resistant, and platinum-sensitive ovarian cancer linked to an inherited BRCA1 or BRCA2 gene mutation. A new type of cancer drug — known as a “PARP inhibitor” — produced promising results in patients with ovarian cancer linked [...] (Source: Libby's H*O*P*E*) Libby's H*O*P*E* blogs http://www.medworm.com/rss/comments.php?id=3501683 Sat, 24 Apr 2010 00:38:57 +0100 3501683 http://www.medworm.com/index.php?rid=3499284&cid=t_103647_136_f&fid=37846&url=http%3A%2F%2Fhealthinfoispower.wordpress.com%2F2010%2F04%2F22%2Fincreased-ovarian-cancer-metastases-identified-in-women-with-brca-gene-mutations-may-shed-light-on-new-treatment-approach%2F U.K. researchers have found that patients with hereditary ovarian cancer – whose tumors are caused by faulty BRCA1 or BRCA2 genes – are more likely to experience metastases of the liver, lung, spleen, and viscera. … [T]he researchers suggest that ovarian cancer patients whose tumors spread to the solid organs … should be tested for [...] (Source: Libby's H*O*P*E*) Libby's H*O*P*E* blogs http://www.medworm.com/rss/comments.php?id=3499284 Thu, 22 Apr 2010 22:32:44 +0100 3499284 http://www.medworm.com/index.php?rid=3420754&cid=t_103647_150_f&fid=35777&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FPharmalot%2F%7E3%2FaaOWXNbIdu0%2F A federal judge struck down patents held by Myriad Genetics on two genes linked to an increased risk of breast and ovarian cancer, essentially challenging the idea that anyone can hold patents on human genes. The opinion (see here) is almost certain to be appealed, but may still have significant implications for the biopharma industry. “This marks the first time a court has found patents on genes unlawful and calls into question the validity of patents now held on approximately 2,000 human genes,” according to the Public Patent Foundation, one of several parties that filed the lawsuit. In explaining his ruling, US District Judge Robert Sweet said he invalidated the patents because DNA’s existence in an isolated form doesn’t alter the fundamental quality of DNA as it... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=3420754 Tue, 30 Mar 2010 12:13:48 +0100 3420754 http://www.medworm.com/index.php?rid=3420680&cid=t_103647_131_f&fid=35743&url=http%3A%2F%2Fthegenesherpa.blogspot.com%2F2010%2F03%2Fend-of-gene-patents.html With the NY district court ruling in ACLU et.al. v USPTO/MYGN it appears clear that the bar for gene patents is super high and most will likely not reach it. Does this mean the end of gene patents or even just the BRCA1/2 patents?No, but it is the beginning of slipshod sequencing and a whole host of labs testing for BRCA1/2 sequences. It is also the making of a SCOTUS case.But here's why I think Myriad STILL is the gold standard.A. They have the experience doing this testingB. They have the infrastructure to handle national samplesC. They have the ability to analyze rare variants best. Why? They have the samples.....That being said, could Quest or LabCorp begin BRCA testing? Yes and they would do a hell of a job.One thing is for certain, Myriad will have a hard time justifying that 3120 US... Gene Sherpas: Personalized Medicine and You blogs http://www.medworm.com/rss/comments.php?id=3420680 Mon, 29 Mar 2010 23:44:00 +0100 3420680 http://www.medworm.com/index.php?rid=3153592&cid=t_103647_136_f&fid=37846&url=http%3A%2F%2Fhealthinfoispower.wordpress.com%2F2010%2F01%2F07%2Felevated-proteins-may-warn-of-ovarian-cancer-but-sufficient-lead-time-predictive-value-still-lacking%2F Fred Hutchinson Cancer Center researchers discovered that concentrations of the serum biomarkers CA125, human epididymis protein 4 (HE4), and mesothelin began to rise 3 years before clinical diagnosis of ovarian cancer, according to a new study published online December 30 in the Journal of the National Cancer Institute. However, the biomarkers became substantially elevated only [...] (Source: Libby's H*O*P*E*) Libby's H*O*P*E* blogs http://www.medworm.com/rss/comments.php?id=3153592 Thu, 07 Jan 2010 22:22:08 +0100 3153592 http://www.medworm.com/index.php?rid=2725213&cid=t_103647_136_f&fid=37846&url=http%3A%2F%2Fhealthinfoispower.wordpress.com%2F2009%2F08%2F21%2Fua-research-team-designing-holographic-imaging-system-for-ovarian-cancer%2F University of Arizona researchers Jennifer Barton and Ray Kostuk have received a five-year, $2.4 million grant from the National Institutes of Health to build the instrument that they hope will one day be used to monitor women at high risk for ovarian cancer. Two University of Arizona [UA] researchers have formed a research team to [...] (Source: Libby's H*O*P*E*) Libby's H*O*P*E* blogs http://www.medworm.com/rss/comments.php?id=2725213 Sat, 22 Aug 2009 02:26:23 +0100 2725213 http://www.medworm.com/index.php?rid=2702485&cid=t_103647_136_f&fid=37846&url=http%3A%2F%2Fhealthinfoispower.wordpress.com%2F2009%2F08%2F14%2Fwomen-often-opt-to-surgically-remove-their-breasts-ovaries-to-reduce-cancer-risk%2F Many women at high risk for breast or ovarian cancer are choosing to undergo surgery as a precautionary measure to decrease their cancer risk, according to a report in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research. PHILADELPHIA – Many women at high risk for breast or ovarian cancer are [...] (Source: Libby's H*O*P*E*) Libby's H*O*P*E* blogs http://www.medworm.com/rss/comments.php?id=2702485 Fri, 14 Aug 2009 21:45:23 +0100 2702485 http://www.medworm.com/index.php?rid=2667652&cid=t_103647_136_f&fid=37846&url=http%3A%2F%2Fhealthinfoispower.wordpress.com%2F2009%2F08%2F03%2Fbeyond-brca1-brca2-u-k-researchers-identify-genetic-defect-that-could-increase-risk-of-ovarian-cancer-up-to-40%2F Scientists have located a region of DNA which – when altered – can increase the risk of ovarian cancer according to research published in Nature Genetics today. An international research group led by scientists based at the Cancer Research UK Genetic Epidemiology Unit, at the University of Cambridge and UCL (University College London) searched [...] (Source: Libby's H*O*P*E*) Libby's H*O*P*E* blogs http://www.medworm.com/rss/comments.php?id=2667652 Mon, 03 Aug 2009 21:59:29 +0100 2667652 http://www.medworm.com/index.php?rid=2649245&cid=t_103647_136_f&fid=37846&url=http%3A%2F%2Fhealthinfoispower.wordpress.com%2F2009%2F07%2F28%2Fvox-populi-libby-well-be-missing-you%2F Vox Populi:  Libby, We’ll Be Missing You. Dear Libby, One year ago today, you left us after an extended battle with ovarian cancer.  You are missed as a wife, a daughter, a sister, an aunt and a cousin.  You were, and continue to be, a very special family member to your loved ones who remain behind.  [...] (Source: Libby's H*O*P*E*) Libby's H*O*P*E* blogs http://www.medworm.com/rss/comments.php?id=2649245 Tue, 28 Jul 2009 21:49:25 +0100 2649245 http://www.medworm.com/index.php?rid=2415712&cid=t_103647_136_f&fid=37846&url=http%3A%2F%2Fhealthinfoispower.wordpress.com%2F2009%2F05%2F17%2Fsymptoms-of-ovarian-cancer-remain-relatively-stabile-over-time-as-reported-by-high-risk-women%2F Researchers from the Fred Hutchinson Cancer Research Center reported recently that symptoms of ovarian cancer tend to be relatively stable over time for women who are at increased risk of ovarian cancer based upon family history of cancer or BRCA 1/2 gene mutation. Researchers from the Fred Hutchinson Cancer Research Center, located in Seattle, Washington, recently [...] (Source: Libby's H*O*P*E*) Libby's H*O*P*E* blogs http://www.medworm.com/rss/comments.php?id=2415712 Mon, 18 May 2009 02:08:18 +0100 2415712 http://www.medworm.com/index.php?rid=2405977&cid=t_103647_136_f&fid=37846&url=http%3A%2F%2Fhealthinfoispower.wordpress.com%2F2009%2F05%2F12%2Fupci-launches-clinical-trial-for-patients-with-hereditary-breast-and-ovarian-cancers%2F “The University of Pittsburgh Cancer Institute (UPCI) will be the primary site for a clinical trial of ABT-888, a drug previously proven in combination treatments to improve chemotherapy’s effectiveness by lowering cancer cells’ resistance to treatment. This trial will, for the first time, examine ABT-888 as a single agent for patients with cancers related to [...] (Source: Libby's H*O*P*E*) Libby's H*O*P*E* blogs http://www.medworm.com/rss/comments.php?id=2405977 Wed, 13 May 2009 01:59:01 +0100 2405977 http://www.medworm.com/index.php?rid=2381062&cid=t_103647_136_f&fid=37846&url=http%3A%2F%2Fhealthinfoispower.wordpress.com%2F2009%2F04%2F30%2Fwomen-of-diverse-ethnic-ancestry-have-similar-risk-of-carrying-brca-mutations-as-those-with-western-european-ancestry%2F ” …The study, performed by researchers at Philadelphia’s Fox Chase Cancer Center and Myriad Genetics, Inc., analyzed the prevalence of BRCA1/BRCA2 gene mutations in patients of different ethnicities at risk for hereditary breast and ovarian cancer. The study included test results of 46,276 women during the ten-year period from 1996 to 2006. Study subjects encompassed [...] (Source: Libby's H*O*P*E*) Libby's H*O*P*E* blogs http://www.medworm.com/rss/comments.php?id=2381062 Thu, 30 Apr 2009 23:12:40 +0100 2381062 http://www.medworm.com/index.php?rid=2299060&cid=t_103647_136_f&fid=37846&url=http%3A%2F%2Fhealthinfoispower.wordpress.com%2F2009%2F03%2F31%2Fpresident-of-md-anderson-outlines-10-steps-to-achieve-progress-against-cancer%2F “The Houston Chronicle recently published a commentary by John Mendelsohn, M.D., president of M. D. Anderson, outlining actions the nation should take to achieve great progress against cancer. … Here are 10 steps we can take to ensure that deaths decrease more rapidly, the ranks of survivors swell, and an even greater number of cancers [...] (Source: Libby's H*O*P*E*) Libby's H*O*P*E* blogs http://www.medworm.com/rss/comments.php?id=2299060 Wed, 01 Apr 2009 01:03:00 +0100 2299060 http://www.medworm.com/index.php?rid=2299065&cid=t_103647_136_f&fid=37846&url=http%3A%2F%2Fhealthinfoispower.wordpress.com%2F2009%2F03%2F24%2Froutine-screening-for-hereditary-breast-and-ovarian-cancer-recommended-by-acog-sgo%2F Evaluating a patient’s risk of hereditary breast and ovarian cancer syndrome is an important first step in cancer prevention and early detection and should be a routine part of ob-gyn practice. Those who are likely to have the syndrome should be referred for further assessment to a clinician with expertise in genetics, according to a [...] (Source: Libby's H*O*P*E*) Libby's H*O*P*E* blogs http://www.medworm.com/rss/comments.php?id=2299065 Wed, 25 Mar 2009 03:55:32 +0100 2299065 http://www.medworm.com/index.php?rid=2218535&cid=t_103647_136_f&fid=37846&url=http%3A%2F%2Fhealthinfoispower.wordpress.com%2F2009%2F02%2F26%2Ftwo-studies-address-risk-reduction-screening-for-brca-12-gene-mutation-carriers%2F “Prophylactic salpingo-oophorectomy - removal of the ovaries and fallopian tubes–reduces the relative risk of breast cancer by approximately 50 percent and the risk of ovarian and fallopian tube cancer by approximately 80 percent in women who carry a mutation in the BRCA1 or BRCA2 gene, researchers report in the January 13 online issue of the [...] (Source: Libby's H*O*P*E*) Libby's H*O*P*E* blogs http://www.medworm.com/rss/comments.php?id=2218535 Thu, 26 Feb 2009 22:56:50 +0100 2218535 http://www.medworm.com/index.php?rid=1883378&cid=t_103647_131_f&fid=34989&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FGeneticsHealth%2F%7E3%2FvRo_X15ST5A%2F Good news for the state of Illinois! Women who are at high risk for developing breast and/or ovarian cancer will receive insurance coverage under Medicaid. Genetic tests for BRCA1 and BRCA2, and counseling will be available for low-income women with a strong family history of breast cancer or previous cancer diagnosis, writes the Chigaco Tribune. Women with mutated BRCA1 or BRCA2 gene are 3 to 7 times more likely to develop breast cancer, and have a 16 to 60 percent lifetime risk for getting ovarian cancer than women without the mutations. Last year, about 22,000 low-income women enrolled in Medicaid were treated for breast cancer. Let’s hope other states follow suit, so more women with very little resources can have themselves tested. What’s not clear from the article, and ... Genetics and Health blogs http://www.medworm.com/rss/comments.php?id=1883378 Fri, 17 Oct 2008 03:09:42 +0100 1883378 http://www.medworm.com/index.php?rid=1769127&cid=t_103647_131_f&fid=35743&url=http%3A%2F%2Fthegenesherpa.blogspot.com%2F2008%2F09%2Fstand-up-to-cancer.html Let's Join together and beat cancer down! As I posted earlier about Christina Applegate and now about Mia Perovetz. Cancer can destroy families. Why not stand up to it. That's what celebrities are doing tonight. My friend Walter recently posted on this.....you can see it Here!We have to beat cancer! Tune in tonight September 5th, at 8:00 pm EST and PST, ABC, CBS and NBC will donate one hour of simultaneous commercial-free prime time for a national fundraising event. Tune in donate and let's stop cancer in its tracks! (Source: Gene Sherpas: Personalized Medicine and You) Gene Sherpas: Personalized Medicine and You blogs http://www.medworm.com/rss/comments.php?id=1769127 Fri, 05 Sep 2008 22:23:00 +0100 1769127 http://www.medworm.com/index.php?rid=1756994&cid=t_103647_136_f&fid=37846&url=http%3A%2F%2Fhealthinfoispower.wordpress.com%2F2008%2F09%2F02%2Fhollywood-celebs-raise-awareness-regarding-hereditary-breast-and-ovarian-cancer%2F Christina Applegate - Samantha Who? Recently diagnosed in July 2008 with breast cancer, Christina Applegate appeared on ABC’s Good Morning America program in August. The talented, Emmy award winning actress is currently the star of the ABC sitcom “Samantha Who?” Applegate came into the Hollywood limelight when she appeared in popular Fox sitcom “Married [...] (Source: Libby's H*O*P*E*) Libby's H*O*P*E* blogs http://www.medworm.com/rss/comments.php?id=1756994 Wed, 03 Sep 2008 16:43:56 +0100 1756994 http://www.medworm.com/index.php?rid=1717562&cid=t_103647_131_f&fid=35743&url=http%3A%2F%2Fthegenesherpa.blogspot.com%2F2008%2F08%2Fchristina-and-jessica-beat-brca1.html I certainly hope my friends at Speigel and Grau get in contact with Christina Applegate. As I suspected and mentioned on August 7th......It seemed, based on the limited family history I had, that Christina Applegate was a BRCA carrier. Today, I find out I am correct. This is timely news as Helix Health is now releasing the CliniCast from May 21st 2008: "How Genomic Medicine is Changing the Management of Breast and Ovarian Cancer". Interestingly, this was the day which GINA was signed into law. In fact it happened right when Jessica Queller announced to the world that doctors who are "too old" to learn genetics should retire. Well Jessica, I am here to teach those doctors.....If they don't want to learn, then I agree. They should retire. If you want to learn more or even take a listen to ou... Gene Sherpas: Personalized Medicine and You blogs http://www.medworm.com/rss/comments.php?id=1717562 Wed, 20 Aug 2008 00:56:00 +0100 1717562 http://www.medworm.com/index.php?rid=1543906&cid=t_103647_131_f&fid=35743&url=http%3A%2F%2Fthegenesherpa.blogspot.com%2F2008%2F06%2Fburrill-reportdecoded.html Consumers are worried about developing genetic based diseases, but remain reluctant to use genetic tests that will provide early warning signs.That is the lead statement in the executive summary from the Burrill and Company Personalized Medicine and Wellness report issued last week. Many may ask "What's this report have to do with me?" many have even doubted the validity of the report in favor of the blogosphere......In the arena of Genomic Medicine, I would say the blogosphere is pretty one sided.....IN fact, that is why the Sherpa is popular. Until I started blogging, this place was pretty much a mutual admiration society. Further proven by the backlash I received when I said that governmental regulation was coming and then came.So let's go back to the poll.....Second LineCompanies need ... Gene Sherpas: Personalized Medicine and You blogs http://www.medworm.com/rss/comments.php?id=1543906 Tue, 24 Jun 2008 09:00:00 +0100 1543906 http://www.medworm.com/index.php?rid=1349801&cid=t_103647_131_f&fid=35743&url=http%3A%2F%2Fthegenesherpa.blogspot.com%2F2008%2F04%2Fjessica-queller-and-brca1.html First I would like to apologize to Spiegel and Grau. I missed you gracious letter. Please give me a call.Second.....I am catching some serious heat about the deCode rant! I never knew so many smokers were hoping to escape cancer and angrily flaming me with emails. Here's a hint ladies and Gentlemen........Quit Smoking and maybe you will avoid cancer. To all of those who decided to fill my gmail yesterday....thanks for reading this blog. I appreciate your interest.I don't know how many of you picked up the USA Today on March 31st, but in it was a profile on Jessica Queller. She has written a book called:Pretty Is What Changes-Impossible Choices, The Breast Cancer Gene, and How I Defied My DestinyAbout the Book....Eleven months after her mother succumbs to cancer, Jessica Queller has herself... Gene Sherpas: Personalized Medicine and You blogs http://www.medworm.com/rss/comments.php?id=1349801 Fri, 04 Apr 2008 12:30:00 +0100 1349801 http://www.medworm.com/index.php?rid=1286654&cid=t_103647_107_f&fid=36585&url=http%3A%2F%2Ffeeds.feedburner.com%2F%7Er%2FHighlightHEALTH%2F%7E3%2F247573921%2F Conclusion Thanks to everyone that contributed articles — it’s been a pleasure to host this months edition of the Cancer Research Carnival. Be sure to take a moment and let your fellow bloggers know this issue is available so that everyone’s hard work can be appreciated and enjoyed by all. You can find more information about the carnival as well as the hosting schedule and past editions at the Cancer Research Blog Carnival. References Cancer Facts & Figures 2008. American Cancer Society. Atlanta, Ga. 2008. Report Says Half a Million Cancer Deaths Have Been Averted Since Death Rate Drop. American Cancer Society Press Release. 2008 Feb 20. Vickers A. Cancer Data? Sorry, Can’t Have It. The New York Times. 2008 Jan 22. Apel et al. Blocked autophagy sensitizes resis... Highlight HEALTH blogs http://www.medworm.com/rss/comments.php?id=1286654 Fri, 07 Mar 2008 20:47:38 +0100 1286654 http://www.medworm.com/index.php?rid=1294839&cid=t_103647_117_f&fid=36026&url=http%3A%2F%2Fblog.healthtalk.com%2Fzimney%2Factor-patrick-swayze-has-cancer-of-the-pancreas%2F The big celebrity news this week is that, unfortunately, Patrick Swayze has pancreatic cancer. It’s unclear what the extent of his disease is because early reports that he might be terminal have been squelched by his team who say that his disease is “limited” and that he has responded well to treatment. We all wish him well, but only time will tell. What’s so unfortunate are the statistics on cancer of the pancreas, which typically has a very high mortality rate with only 15 to 20 percent of people alive after five years. The biggest problem with pancreatic cancer is that the organ is hidden away and its cancer doesn’t usually cause any symptoms until it’s far advanced. That coupled with the facts that there’s no good screening methods and that treatments for cancer of the pa... Dr. Z's Medical Report blogs http://www.medworm.com/rss/comments.php?id=1294839 Fri, 07 Mar 2008 17:28:37 +0100 1294839 http://www.medworm.com/index.php?rid=828073&cid=t_103647_87_f&fid=34865&url=http%3A%2F%2Fwww.thecancerblog.com%2F2007%2F08%2F29%2Fthought-for-the-day-what-would-prevent-you-from-taking-preventa%2F Filed under: Thought for the DayHere's an interesting story: Women in the Canadian province of Quebec are less likely than women elsewhere to take preventative action after learning that they have a certain gene linked to breast and ovarian cancers. Women who carry the BRCA1 or BRCA2 gene mutations have a higher risk of developing cancer, prompting many women to either have their breast or ovaries removed. Two thirds of women in Quebec took no preventative actions after learning of their risk, while only one third failed to take preventative steps in the rest of the country. So, my thought for the day is: What would prevent someone from taking action against a disease that could kill them? Religious beliefs? Lack of knowledge about the disease? Lack of money? And if you found out you were ... The Cancer Blog blogs http://www.medworm.com/rss/comments.php?id=828073 Wed, 29 Aug 2007 04:00:00 +0100 828073 http://www.medworm.com/index.php?rid=734011&cid=t_103647_131_f&fid=35743&url=http%3A%2F%2Fthegenesherpa.blogspot.com%2F2007%2F07%2Fthis-week-in-nejm.html So I have been reading about how the new article in the New England Journal of Medicine shows that BRCA gene mutations are not worse than sporadic breast cancers due to non-BRCA mutations.If you look at the article you will see that there are many reasons why this is flawed thinking. But more importnatly it flies in the face of another study which actually showed and increased risk in worse outcomes with BRCA1 mutations.So on closer inspection what was the NEJM article about?They took all breast cancer specimens available in Israel's National Healthcare repository and looked for 3 I repeat 3 FOUNDER MUTATIONS....... This immediately makes the study invalid to comparison on women who have non ashkenazi mutations, especially if they are not founder mutations.Secondly they analyzed outcomes r... Gene Sherpas: Personalized Medicine and You blogs http://www.medworm.com/rss/comments.php?id=734011 Fri, 13 Jul 2007 01:20:00 +0100 734011 http://www.medworm.com/index.php?rid=654444&cid=t_103647_87_f&fid=34865&url=http%3A%2F%2Fwww.thecancerblog.com%2F2007%2F06%2F02%2Ffour-more-breast-cancer-genes-found%2F Filed under: Breast Cancer, Research, Daily newsFour more breast cancer genes have been uncovered by a team of international scientists, a discovery that may rival in importance the cloning of the BRCA2 gene in 1995. Scientists say women with mutated versions of these genes have a pretty low risk of contracting breast cancer, though, and it's unlikely that screening tests for such mutations will be developed.Genetic causes of breast cancer account for 5 to 10 percent of all cases. Lifestyle factors, such as smoking and environmental influences, account for the rest. Until now, only 25 percent of the genes suspected to cause inherited breast cancer had been identified. The four new genes -- FRFR2, TNRC9, MAP3K1, and LSP1 -- are believed to be fairly common yet account for only four percent ... The Cancer Blog blogs http://www.medworm.com/rss/comments.php?id=654444 Sat, 02 Jun 2007 04:00:00 +0100 654444 http://www.medworm.com/index.php?rid=687125&cid=t_103647_131_f&fid=35743&url=http%3A%2F%2Fthegenesherpa.blogspot.com%2F2007%2F05%2Fblame-portugal.html With all apologies to my good friend Rick Vidal at My Biotech Life I am here to report a tremendous disservice done to all of us western hemispherians(is that even a word?) by the Portuguese.On the 20th of May in the Journal of Clinical Oncology an article was presented examining the BRCA2 rearrangements in 210 high risk cancer families. The rearrangement they described, occurs in 1/3 of all male breast cancers that they identified. Why the big deal? Well, only 7 rearrangements to date have been described in the BRCA2 gene. In addition these rearrangements are not picked up in point mutation sequencing. Which brings me to a very important point regarding genetic testing. No Test Gives a Yes or No Answer. These tests require skilled interpretation as well as counseling to evaluate for furth... Gene Sherpas: Personalized Medicine and You blogs http://www.medworm.com/rss/comments.php?id=687125 Thu, 24 May 2007 15:45:00 +0100 687125 http://www.medworm.com/index.php?rid=509314&cid=t_103647_87_f&fid=34865&url=http%3A%2F%2Fwww.thecancerblog.com%2F2007%2F03%2F29%2Fbreast-mri-now-officially-recommended%2F Filed under: Breast Cancer, Daily newsI get mammograms every six months. I get ultrasounds every six months. I get a breast MRI every year. That's my typical screening routine, intended to keep breast cancer from invading my life for a second time. This combination of testing -- primarily the MRI part -- has not been typical for all at-risk women. It's just the plan my doctors have determined is the best insurance policy for me. But as of yesterday, the American Cancer Society began recommending regular use of MRI scans, rather than conventional mammograms, for women facing a breast cancer risk of 15 percent or more.Family history places one to two percent of women at a 20 percent higher risk of developing the disease than women without such a history. Women carrying a BRCA1 or BRCA 2 gene... The Cancer Blog blogs http://www.medworm.com/rss/comments.php?id=509314 Thu, 29 Mar 2007 04:00:00 +0100 509314 http://www.medworm.com/index.php?rid=481866&cid=t_103647_87_f&fid=34865&url=http%3A%2F%2Fwww.thecancerblog.com%2F2007%2F03%2F19%2Fmore-risk-factors-added-to-breast-cancer-list%2F Filed under: Breast Cancer, Prevention, Daily newsSimply being female puts all women at risk for breast cancer. That and age, race, family history, personal history, genetic make-up, when they had children, when they reach menopause, and a whole host of other possible factors.Now U.S. doctors are officially calling body mass index, breast density, and alcohol consumption predictors of the disease, says Therese Bevers, medical director of the Cancer Prevention Center, at the University of Texas M.D. Anderson Cancer Center in Houston.Bevers helped write updated guidelines for the prevention of breast cancer and presented them at the 12th annual National Comprehensive Cancer Network in Hollywood, Florida on Friday. The guidelines, featuring the revised list of risk factors, also offer treatme... The Cancer Blog blogs http://www.medworm.com/rss/comments.php?id=481866 Mon, 19 Mar 2007 04:00:00 +0100 481866