MedWorm provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest medical blog items that have been tagged with 'c peptide'. Sat, 03 Sep 2011 02:29:13 +0100 http://www.medworm.com/index.php?rid=4230118&cid=t_113645_83_f&fid=34856&url=http%3A%2F%2Finsidesurgery.com%2F2010%2F12%2Finsulinoma-2%2F is a type of pancreatic neuroendocrine tumor which arise from the insulin producing beta cells in the pancreas. They are almost always benign (90%), are the most commonly occurring neuroendocrine tumor, and are equally distributed throughout the pancreas parenchyma. The classic symptom complex is Whipple’s triad – neuromuscular symptoms with fasting or exercise, hypoglycemia, and symptom relief with administration of glucose. The diagnosis is largely suggested by laboratory studies of hypoglycemia in the setting of hyperinsulinism. Surreptitious insulin administration can be detected by testing for C-peptide levels, which are high in insulinoma and normal if the high insulin levels are secondary to administered doses. (Source: Inside Surgery) Inside Surgery blogs http://www.medworm.com/rss/comments.php?id=4230118 Sun, 05 Dec 2010 18:22:10 +0100 4230118 http://www.medworm.com/index.php?rid=3440998&cid=t_113645_134_f&fid=34841&url=http%3A%2F%2Fwww.diabetesmine.com%2F2010%2F04%2Fbeating-the-odds-with-richard-vaughn-over-half-a-century-of-diabetes.html Richard Vaughn is a bit of a legend in the diabetes online community. Known more widely as Richard157 on several diabetes forums, Richard began sharing his story of living with type 1 diabetes for over 60 years via forum posts in 2007 and has become an inspiration for many. Last week, Richard also became a [...] (Source: Diabetes Mine) Diabetes Mine blogs http://www.medworm.com/rss/comments.php?id=3440998 Tue, 06 Apr 2010 13:00:24 +0100 3440998 http://www.medworm.com/index.php?rid=1815390&cid=t_113645_134_f&fid=35137&url=http%3A%2F%2Fdiabetesupdate.blogspot.com%2F2008%2F09%2Fwhat-does-that-c-peptide-test-result.html This study concluded this inconsistency was greatest, "...especially at higher C-peptide concentrations. Within-laboratory imprecision also varied, with some methods giving much more consistent results than others." It is usually suggested that because of the different test protocols and reference ranges in use, you use the same lab to compare C-peptide values, when trying to determine if your C-peptide levels are dropping. But the results of the study above suggest that "within laboratory imprecision" is significant enough to make this a questionable strategy, too.Labs may also not provide on a reference range for fasting C-peptide test results since most doctors order only fasting C-peptide tests. This can be a problem for those of us who have forms of diabetes where our beta cells are a... Diabetes Update blogs http://www.medworm.com/rss/comments.php?id=1815390 Mon, 22 Sep 2008 13:29:00 +0100 1815390 http://www.medworm.com/index.php?rid=868212&cid=t_113645_87_f&fid=34867&url=http%3A%2F%2Fwww.thediabetesblog.com%2F2007%2F09%2F13%2Fthe-specials-tonight-are-fulminant-and-non-fulminant%2F This study may be the antithesis of conventional wisdom for preventing complications. Staking all hopes on blood sugar control is heavily optimistic. Yes controlling blood sugar does lessen the workload for existing beta cells, and thus extends the lifespan of each beta cell. Research suggests that c-peptide offers protection to beta cells, both from apoptosis (cell death) and encourages new cell growth. This new cell growth applies to beta cells and other cells of the body that endure long-term Type 1 diabetes complications. Diabetics are instructed that maintaining normal blood sugars is the Holy Grail of preventing long-term complications. Yes and no. The truth is controlling your blood sugar will not allow complications of Type 1 diabetes to develop as quickly, presuming you still had ... The Diabetes Blog blogs http://www.medworm.com/rss/comments.php?id=868212 Thu, 13 Sep 2007 04:00:00 +0100 868212 http://www.medworm.com/index.php?rid=776156&cid=t_113645_134_f&fid=35152&url=http%3A%2F%2Fsstrumello.blogspot.com%2F2007%2F08%2Fshow-me-money.html August 1 marked the start of JDRF's "Promise to Remember Me" campaign. A major objective of the campaign this year is to convince the Federal Government to renew the Special Statutory Funding Program for Type 1 Diabetes Research, which is set to expire in 2008. President George W. Bush signed the last extension of that program (in 2000 or 2001, I can't recall), so its possible he will also approve it this year if the legislation is sent to the White House for approval. What's at stake is more than one-third (35% to be exact) of all Federal funding allocated to type 1 diabetes research which comes from that "special" program. (The remainder comes from the annually appropriated funds to the NIH to support type 1 diabetes, and a tiny, highly targeted funding program also exists within the Dep... Scott's Web Log blogs http://www.medworm.com/rss/comments.php?id=776156 Thu, 02 Aug 2007 18:15:00 +0100 776156 http://www.medworm.com/index.php?rid=682744&cid=t_113645_87_f&fid=34867&url=http%3A%2F%2Fwww.thediabetesblog.com%2F2007%2F06%2F20%2Fdiamyd-clinical-trial-speed-bump%2F Filed under: Type 1, Childhood, Drugs, Research, Opinion, ProductsCircumstances of confusion invalidated a Diamyd clinical trial to protect insulin-producing cells in diabetes patients. This confusion amounts to a speed bump, but Diamyd intends to press on. The company admitted hat the Phase II clinical trial of its gene therapy had been botched following a mix up over which patients received the drug and which got placebo. Diamyd is a vaccine based on GAD65, a major factor for diabetes due to an autoimmune reaction. The company designed the vaccine to reduce the need of insulin injections and prevent the destruction of beta cells that produce insulin in the pancreas. Also, by protecting these cells, it may allow them to regenerate in a non-autoimmune environment, and possibly set the stag... The Diabetes Blog blogs http://www.medworm.com/rss/comments.php?id=682744 Wed, 20 Jun 2007 04:00:00 +0100 682744 http://www.medworm.com/index.php?rid=637984&cid=t_113645_87_f&fid=34867&url=http%3A%2F%2Fwww.thediabetesblog.com%2F2007%2F05%2F24%2Fi-love-you-you-re-perfect-now-change%2F Filed under: Type 1, Type 2, Childhood, Adult Onset, Lifestyle, Drugs, Research, SupportFor more the more than 300,000 users that once relied on animal-derived insulin, the final chapter of animal insulin is finally ending for the US market. In December 2007, Novo Nordisk has officially decided to discontinue making animal-insulin. Their explanation doesn't go into great detail why they chose to discontinue it. But the supporting evidence they use to warrant the decision is a little weak. Novo says, animal insulin is derived from the pancreas of slaughtered animals. This statement is as true as the statement "human insulin is derived from the pancreas of slaughtered humans". Novo continues, since that time there has been significant improvement of insulin quality and formulation. Absolute... The Diabetes Blog blogs http://www.medworm.com/rss/comments.php?id=637984 Thu, 24 May 2007 04:00:00 +0100 637984 http://www.medworm.com/index.php?rid=612021&cid=t_113645_87_f&fid=34867&url=http%3A%2F%2Fwww.thediabetesblog.com%2F2007%2F05%2F14%2Fmad-money-says-novo-nordisk-sell-sell-sell%2F Filed under: Type 1, Type 2, Childhood, Adult Onset, Drugs, Research, Daily News, OpinionMad Money is a stock show on CNBC hosted by Jim Cramer - a well-known iron fist on Wall Street. He has a following of stock enthusiasts who regard his recommendations (buy or sell) as gospel. Why is he so good at what he does? He just wants to help you make money. And to this end -- the reason I bring Cramer's passionate drive to The Diabetes Blog is simple: last week he called Novo Nordisk as a SELL. Cramer said he's beginning to worry about a backlash on drug stocks. He advised that viewers should not be greedy and should take gains in Novo Nordisk (NVO). Perhaps the NY Times article raised some eyebrows at Big Pharma. It appears doctors are receiving handsome gifts and stipends for handing out samp... The Diabetes Blog blogs http://www.medworm.com/rss/comments.php?id=612021 Mon, 14 May 2007 04:00:00 +0100 612021 http://www.medworm.com/index.php?rid=558434&cid=t_113645_87_f&fid=34867&url=http%3A%2F%2Fwww.thediabetesblog.com%2F2007%2F04%2F21%2Fc-peptide-the-path-to-enlightenment-of-diabetic-complications%2F Filed under: Type 1, Childhood, Lifestyle, Drugs, Research, OpinionAs a diabetic with the esteemed honor of pouring my heart and soul out for an audience as well-informed as you - I feel it is OUR job to inform our doctor's of the important discoveries being made in diabetes. The discovery I am most concerned with these days is raising awareness of C-peptide. When I learned that all forms of synthetic human insulin these days DO NOT have C-peptide (like natural human insulin does) I asked my doctor what C-peptide does. My doctor explained, "C-peptide is nothing more than a biomarker to tell us [doctors] how much insulin your body is naturally producing." When Chrissie in Belgium asked her doctor he told her that [C-peptide] has absolutely no importance. Uh oh... Doctor's are convinced th... The Diabetes Blog blogs http://www.medworm.com/rss/comments.php?id=558434 Sat, 21 Apr 2007 04:00:00 +0100 558434 http://www.medworm.com/index.php?rid=554445&cid=t_113645_87_f&fid=34867&url=http%3A%2F%2Fwww.thediabetesblog.com%2F2007%2F04%2F19%2Fdiamyd-results-on-newly-diagnosed-type-1-diabetes%2F Filed under: Type 1, Childhood, Adult Onset, Drugs, ResearchDiamyd showed promising results in slowing the attack on remaining islets in recently diagnosed type 1 diabetics. Diamyd is a therapy specifically designed to preserve residual beta cells in recently diagnosed type 1-diabetes. The results from the Diamyd study demonstrated that the group of 35 recently diagnosed type 1-diabetes patients that received Diamyd produced approximately twice as much meal stimulated insulin, as measured by C-peptide levels. These results were present 15 months after the first treatment. Insulin and C-peptide are produced in equal amounts. As C-peptide is easier to measure, meal stimulated C-peptide levels is the most important parameter to follow in a type 1-diabetes study where the aim is to preserve be... The Diabetes Blog blogs http://www.medworm.com/rss/comments.php?id=554445 Thu, 19 Apr 2007 04:00:00 +0100 554445 http://www.medworm.com/index.php?rid=545825&cid=t_113645_87_f&fid=34867&url=http%3A%2F%2Fwww.thediabetesblog.com%2F2007%2F04%2F16%2Fcustomer-for-life-but-only-what-they-want-to-sell%2F This study was published around the time when all of the synthetic human insulins were sweeping the Nation. I tried calling my local CVS Pharmacy on Saturday morning to see if I could get some purified porcine insulin. No such luck. Go figure. The big guys were successful at convincing the medical community and patients that no other insulin is better. Correction - no other insulin is cheaper to manufacture and that means it is better for them. And the importance of C-peptide was overlooked entirely - or was it? C-peptide prevents the complications associated with injecting insulin - but that sounds like another marketable drug. After all - synthetic human insulin doesn't have C-peptide. REAL HUMAN INSULIN does (the way it comes out of the beta cells, in natural form, it does)!!! And as lo... The Diabetes Blog blogs http://www.medworm.com/rss/comments.php?id=545825 Mon, 16 Apr 2007 04:00:00 +0100 545825 http://www.medworm.com/index.php?rid=541236&cid=t_113645_87_f&fid=34867&url=http%3A%2F%2Fwww.thediabetesblog.com%2F2007%2F04%2F13%2Fada-response-back-and-forthcoming%2F Filed under: Type 1, Childhood, Adult Onset, Daily News, Events, Opinion, SupportFair and balanced, just like Fox News -- I want to let everyone know that the "Matt P" I spoke to, at the ADA responded to my blog about the aforementioned conversation. His response is #17 and it is sincere and genuine -- certifiable in my book. Again, let me reiterate that the nature of my call to the ADA was to ask for their assistance in getting a big pharmaceutical company to sponsor C-peptide FDA trials here in the US. Thanks again to Matt. He really is doing all he can, but there seems to be a suspicious roadblock holding up the research here in the US. Any guesses? Without further adieu, here's Matt: I hope people will take time to read my reply to yesterday's post about ADA and c-peptide. I work for A... The Diabetes Blog blogs http://www.medworm.com/rss/comments.php?id=541236 Fri, 13 Apr 2007 04:00:00 +0100 541236 http://www.medworm.com/index.php?rid=503970&cid=t_113645_87_f&fid=34867&url=http%3A%2F%2Fwww.thediabetesblog.com%2F2007%2F03%2F27%2Fc-peptide-missing-in-action%2F Filed under: Type 1, Type 2, Childhood, Adult Onset, Lifestyle, Drugs, ResearchWhen treating diabetes, today's doctors focus on establishing blood glucose control, but often overlook the need to protect against common diabetic complications such as blindness, kidney damage, and nerve damage. The DCCT, even with a comprehensive treatment program, had a complication rate of approximately 40% of participants. People who do not have diabetes make insulin with C-peptide. Those of us diabetics who inject synthetic insulin do not get the C-peptide. When scientists began developing insulin - they weeded out the pieces of the amino acid chain they felt were insignificant in lowering blood glucose. Synthetic insulin was designed to reduce the dangerous buildup of excess sugar in the bloodstream. Uh ... The Diabetes Blog blogs http://www.medworm.com/rss/comments.php?id=503970 Tue, 27 Mar 2007 04:00:00 +0100 503970 http://www.medworm.com/index.php?rid=497207&cid=t_113645_87_f&fid=34867&url=http%3A%2F%2Fwww.thediabetesblog.com%2F2007%2F03%2F23%2Fnew-immune-modulating-drugs%2F Filed under: Type 1, Type 2, Childhood, Adult Onset, Drugs, Research, ProductsJust like a referee to normalize play throughout the game - DiaKine Therapeutics is developing ways to normalize the body's immune system. The new drugs modulate cytokines, part of the body's immune system, which mistakenly attack normal organs and tissue and cause diseases such as: diabetes, multiple sclerosis and inflammatory bowel disease. Research by Dr. Nadler and his collaborators published in 2006 showed that controlling certain cytokines can arrest the progression of, or reverse, type 1 diabetes in an animal model. The company's first product, IsletLifeLSF Media 1 is designed to improve the viability and insulin producing capabilities of harvested islet cells prior to transplant. This would potentially i... The Diabetes Blog blogs http://www.medworm.com/rss/comments.php?id=497207 Fri, 23 Mar 2007 04:00:00 +0100 497207 http://www.medworm.com/index.php?rid=478744&cid=t_113645_87_f&fid=34867&url=http%3A%2F%2Fwww.thediabetesblog.com%2F2007%2F03%2F14%2Fstop-your-insulin-inhibitions%2F Filed under: Type 2, Adult Onset, Diet, Lifestyle, ResearchKnocking out the gene for a peptide associated with insulin was shown to protect mice against the harmful effects of a high-fat diet. Urocortin 3 plays a role in the increased production of insulin in response to high caloric intake in animals. Scientists found that by removing the urocortin 3 gene from mice, they did not develop the age-related insulin resistance and high blood sugar observed in the normal control mice. The metabolisms of normal mice were compared to the metabolisms of those without the urocortin 3 gene. When placed on a high caloric diet for three months, the mice without the urocortin 3 gene packed on the same amount of weight but had lower insulin levels. But these mice also had lower blood sugar, improved gluc... The Diabetes Blog blogs http://www.medworm.com/rss/comments.php?id=478744 Wed, 14 Mar 2007 04:00:00 +0100 478744