MedWorm provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest medical blog items that have been tagged with 'cancer dna'. Sat, 03 Sep 2011 02:15:00 +0100 http://www.medworm.com/index.php?rid=3119028&cid=t_211874_136_f&fid=36070&url=http%3A%2F%2Fnetwork.nature.com%2Fpeople%2Fbasanta%2Fblog%2F2009%2F12%2F21%2Fis-the-dna-in-our-cells-always-the-same This challenges one of my fundamental assumptions in biology: that of all somatic cells sharing the same genome. In an article entitled BAK1 Gene Variation and Abdominal Aortic Aneurysms the authors show that the BAK1 gene, associated with apoptosis, exists in multiple variants in our bodies. Specifically the authors found differences between the gene found in the blood cells and other tissues. The authors also hypothesise that multiple variants of genes may exist within nondiseased tissues. Until now the assumption was that only tumour cells had a different DNA than the other eukaryotic cells in our organism. These results represent a challenge for a multitude of genetic studies based on the assumption that the genetics of blood cells (which are comparatively easy to obtain for those stu... Cancerevo: Evolution and cancer blogs http://www.medworm.com/rss/comments.php?id=3119028 Wed, 23 Dec 2009 21:46:05 +0100 3119028 http://www.medworm.com/index.php?rid=2950962&cid=t_211874_136_f&fid=37846&url=http%3A%2F%2Fhealthinfoispower.wordpress.com%2F2009%2F11%2F01%2Funusual-metals-may-forge-new-ovarian-colon-cancer-drugs%2F Drugs made using unusual metals could form an effective treatment against colon and ovarian cancer, including cancerous cells that have developed immunity to other drugs, according to research at the University of Warwick and the University of Leeds. Drugs made using unusual metals could form an effective treatment against colon and ovarian cancer, including cancerous cells [...] (Source: Libby's H*O*P*E*) Libby's H*O*P*E* blogs http://www.medworm.com/rss/comments.php?id=2950962 Mon, 02 Nov 2009 02:57:13 +0100 2950962 http://www.medworm.com/index.php?rid=2882976&cid=t_211874_86_f&fid=36669&url=http%3A%2F%2Ffadelibrary.wordpress.com%2F2009%2F10%2F12%2Fnew-england-journal-of-medicine-2009-vol-361-no-15%2F This article looks at how DNA damage can cause cancer and many other diseases related to ageing. The author presents evidence that cancer and diseases of ageing are two sides of the DNA damage problem. (Print subscription held at Fade Library) Posted in Journals Tagged: Ageing, Cancer, DNA Damage (Source: Fade Library) Fade Library blogs http://www.medworm.com/rss/comments.php?id=2882976 Mon, 12 Oct 2009 10:49:29 +0100 2882976 http://www.medworm.com/index.php?rid=1955292&cid=t_211874_131_f&fid=34989&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FGeneticsHealth%2F%7E3%2FfWi6LNJnRnQ%2F For the first time, US researchers have decoded all the genes of a woman who died of myeloid leukemia, and they found 10 mutations that contributed to the development of her cancer. This finding is significant on several fronts. It’s the first time that a cancer genome has been sequenced. The scientists took samples of both cancer and normal skin cells from the same woman, and sequenced the DNA on both samples. Previous to this, the focus was on select regions of the genome, called candidate regions, suspected of carrying genes that cause or contribute to cancer. The study also found that 8 of the 10 mutations have never been suspected as contributing to the disease. The researchers found them on every cancer cell and none in the normal samples, which suggests that these mutations ... Genetics and Health blogs http://www.medworm.com/rss/comments.php?id=1955292 Wed, 12 Nov 2008 14:51:03 +0100 1955292 http://www.medworm.com/index.php?rid=1791659&cid=t_211874_105_f&fid=35048&url=http%3A%2F%2Ffeeds.feedburner.com%2F%7Er%2FMedicineAndMan%2F%7E3%2F391822458%2F Not according to this article in Discover Magazine. Alan E. Guttmacher, now acting director of the National Human Genome Research Institute at the National Institutes of Health, agrees with Khoury. “If you read the fine print carefully, these Web sites don’t usually make false claims, but I think a lot of people will have false hopes. The information is incomplete at best and, in some cases, very likely wrong,” Guttmacher says. “The results look scientific,” he adds, but don’t be fooled. Bottom line: If there is no indication, don’t waste money. (Image source: Wikipedia) And of course, there are certain conditions in which DNA testing may be worth it, especially when there are multiple family members in multiple generations afflicted by a certain disorder (e.g. BRCA... Medicine and Man blogs http://www.medworm.com/rss/comments.php?id=1791659 Sat, 13 Sep 2008 21:30:28 +0100 1791659 http://www.medworm.com/index.php?rid=1399177&cid=t_211874_131_f&fid=35008&url=http%3A%2F%2Fscienceroll.com%2F2008%2F04%2F25%2Fpersonalized-medicine-real-clinical-examples%2F There are more than 60 articles in the personalized medicine category on my blog and I have a page dedicated to this emerging field of medicine. I also wrote a summary about it. But now it is time to show you some real examples; some cases and ideas that could play a major role in the future of healthcare. Genetic tests and pharmacogenetic variants which are used in clinical practice or will be used soon. I would like to consider this post as a continuously developing collection or database of examples and ideas. Please let me know if you know other examples of personalized medicine that were published in a peer-reviewed journal. Azathioprine (AZA) and 6-mercaptopurine (6- MP) in inflammatory bowel disease¹: Thiopurine S-methyltransferase (TPMT) is a key metabolic enzyme for azathiopri... ScienceRoll blogs http://www.medworm.com/rss/comments.php?id=1399177 Fri, 25 Apr 2008 19:00:41 +0100 1399177 http://www.medworm.com/index.php?rid=1392532&cid=t_211874_131_f&fid=34989&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FGeneticsHealth%2F%7E3%2F275796141%2F (Photo: Breast cancer cell , courtesy www.hopeforcancer.com) Scientists believe they have identified a gene that may be able to limit the growth of breast cancer tumors. The US National Cancer Institute, led by geneticist Kent Hunter found in tests on mice that tumors containing the bromodomain 4  or Brd4 gene ended up 10 times smaller than ones that did not. In typically growing cells, Brd4 is a nuclear protein that’s associated with chromatin. It apparently influences DNA replication and cell cycle progression. Because of its previously identified physical interaction with an invasiveness-suppressing GTPase activating protein called Sipa1, Hunter and his colleagues decided to delve into Brd4’s role in breast cancer. The team then carried out research into 1,240 patients, split bet... Genetics and Health blogs http://www.medworm.com/rss/comments.php?id=1392532 Wed, 23 Apr 2008 01:09:35 +0100 1392532 http://www.medworm.com/index.php?rid=1258595&cid=t_211874_150_f&fid=35777&url=http%3A%2F%2Ffeeds.feedburner.com%2F%7Er%2FPharmalot%2F%7E3%2F241437369%2F The genetic mutations in cancer cells may vary in every patient, a study found, suggesting that drugs will need to be tailored more finely to small groups, The Wall Street Journal reports. The small study, by doctors at the Brigham and Women’s Hospital in Boston and scientists from a gene-reading unit of Roche Holding AG, is among the first to look comprehensively at the genes in cancerous tumors to find which genes went awry. The docs examined four patients with a rare and deadly lung-sac cancer called pleural mesothelioma, which strikes about 3,000 people a year. Every patient’s tumor had a different group of mutated genes, and no gene was mutated in more than one patient. That could explain why chemotherapy drugs work well in some patients and not at all in others, but it a... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=1258595 Tue, 26 Feb 2008 11:35:34 +0100 1258595 http://www.medworm.com/index.php?rid=1132178&cid=t_211874_131_f&fid=34989&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FGeneticsHealth%2F%7E3%2F212104559%2F    Male Down’s Syndrome with trisome at chromosome 21 People with Down’s Syndrome are less likey to get solid tumor cancers, research from Johns Hopkins University has revealed. Up to 95% of Down’s syndrome cases are caused by “trisomy 21″, in which the baby has three, rather than two, copies of chromosome 21, and the hundreds of genes it contains. Advances in medical management of Down’s Syndrome patients has increased life expectancy from around 30 years of age to over 60 years of age.  This increase led to some studies finding that adults with Down’s syndrome appear to have less chance of developing certain cancers which involved “solid” tumors. On mouse studies, the Johns Hopkins team pinpointed a single gene, Ets2, and found t... Genetics and Health blogs http://www.medworm.com/rss/comments.php?id=1132178 Sun, 06 Jan 2008 16:13:30 +0100 1132178 http://www.medworm.com/index.php?rid=1002517&cid=t_211874_131_f&fid=35008&url=http%3A%2F%2Fscienceroll.com%2F2007%2F11%2F04%2Fgene-genie-19-geneticalization%2F Many thanks to Ricardo Vidal for the logo! Gene Genie is the blog carnival of genes and gene-related diseases. Our plan is to cover the whole genome before 2082 (it means 14-15 genes every two weeks). But we also accept articles on the news of genomics and personalized genetics. Let’s get ready to the geneticalization: DNA: Hsien-Hsien Lei at Eye on DNA tells us that New Line Genetics and SellMyDNA.com Offer $5,000 for Your DNA. Would you sell it? Nature’s Nascent has a short report about the amazing story of Hugh Rienhoff, his daughter and her DNA. Misha Angrist at Genomeboy comments the same story in the Don’t try this at home, kids post. Genes: Matt Mealiffe at DNA and You talks about several genes linked to eye color. Steve Murphy, our Gene Sherpa, expresses his opinio... ScienceRoll blogs http://www.medworm.com/rss/comments.php?id=1002517 Sun, 04 Nov 2007 10:10:37 +0100 1002517 http://www.medworm.com/index.php?rid=944703&cid=t_211874_131_f&fid=35743&url=http%3A%2F%2Fthegenesherpa.blogspot.com%2F2007%2F10%2Finteresting-readers.html Over the last week I have been working on a little personal genome search project. I was contacted by one of my readers to help her find someone to "donate" her genome to. Initially I was surprised to receive such a request. Especially because I have railed against using the genome for a crystal ball.But she was vehement that she wanted to donate her genome. Now I Have to tell you that I was then convinced of her altruism. She didn't know where to turn so we began with the usual suspects Dr Church, Dr Collins, Dr Rothberg, Hodosh. But when we were turned away a window opened.I turns out Dr Venter's Institute is looking to turn out 10k genomes in 10 years. The perfect project.....provided these subjects have appropriate care providers to help out......Since Helix Health is taking patients n... Gene Sherpas: Personalized Medicine and You blogs http://www.medworm.com/rss/comments.php?id=944703 Thu, 11 Oct 2007 22:17:00 +0100 944703 http://www.medworm.com/index.php?rid=966607&cid=t_211874_107_f&fid=36585&url=http%3A%2F%2Ffeeds.feedburner.com%2F%7Er%2FHighlightHealth%2F%7E3%2F160625653%2F This article was published on Highlight HEALTH. (Source: Highlight HEALTH) Highlight HEALTH blogs http://www.medworm.com/rss/comments.php?id=966607 Mon, 24 Sep 2007 14:23:18 +0100 966607 http://www.medworm.com/index.php?rid=687113&cid=t_211874_131_f&fid=35743&url=http%3A%2F%2Fthegenesherpa.blogspot.com%2F2007%2F06%2Fnot-all-drugs-benefit-all-man.html While Bertalan Mesko at ScienceRoll is introducing us to the best medicine 2.0 tools, i am reviewing some results from the American Society of Clinical Oncology meeting last week.In another example of how we need to examine patients pharmacogenomics prior to instituting therapy the SWOG (South Western Oncology Group) in the U.S. releases results of a collaborative effort with two clinical groups in Japan (Japan Multinational Trial Organization). The researchers were interested in how these different groups metabolized certain chemotherapeutic agents Paclitaxel and Carboplatin. Now what is interesting about this study presented at the ASCO conference is the fact that they were able to isolate two gene polymorphisms responsible for these effects. In patients with certain variations in the CY... Gene Sherpas: Personalized Medicine and You blogs http://www.medworm.com/rss/comments.php?id=687113 Sat, 09 Jun 2007 12:14:00 +0100 687113 http://www.medworm.com/index.php?rid=654444&cid=t_211874_87_f&fid=34865&url=http%3A%2F%2Fwww.thecancerblog.com%2F2007%2F06%2F02%2Ffour-more-breast-cancer-genes-found%2F Filed under: Breast Cancer, Research, Daily newsFour more breast cancer genes have been uncovered by a team of international scientists, a discovery that may rival in importance the cloning of the BRCA2 gene in 1995. Scientists say women with mutated versions of these genes have a pretty low risk of contracting breast cancer, though, and it's unlikely that screening tests for such mutations will be developed.Genetic causes of breast cancer account for 5 to 10 percent of all cases. Lifestyle factors, such as smoking and environmental influences, account for the rest. Until now, only 25 percent of the genes suspected to cause inherited breast cancer had been identified. The four new genes -- FRFR2, TNRC9, MAP3K1, and LSP1 -- are believed to be fairly common yet account for only four percent ... The Cancer Blog blogs http://www.medworm.com/rss/comments.php?id=654444 Sat, 02 Jun 2007 04:00:00 +0100 654444 http://www.medworm.com/index.php?rid=687122&cid=t_211874_131_f&fid=35743&url=http%3A%2F%2Fthegenesherpa.blogspot.com%2F2007%2F05%2Fso-whaddya-think-rick-from-my-biotech.html So Whaddya Think? Rick from My Biotech Life put together this little guy. He seems motivated, excited and ready to hit the trail. But I need to know....Should he stay or should he go? Because the Sherpa Shoppe is here! Oh and about this weekend's posts regarding "major breast cancer genes" The media seems to think they are the best thing since BRCAs.The Sherpa Says: Hogwash. Those genes have so little penetrance that a family history will tell you more. And to Hsien and EyeOnDNA, if you don't have a family history, then an environmental history will indicate even more risk than these genes. One things for sure, I am glad I don't live in Canada. But as for the Diet Coke....I threw mine out yesterday :) (Source: Gene Sherpas: Personalized Medicine and You) Gene Sherpas: Personalized Medicine and You blogs http://www.medworm.com/rss/comments.php?id=687122 Tue, 29 May 2007 20:30:00 +0100 687122 http://www.medworm.com/index.php?rid=687125&cid=t_211874_131_f&fid=35743&url=http%3A%2F%2Fthegenesherpa.blogspot.com%2F2007%2F05%2Fblame-portugal.html With all apologies to my good friend Rick Vidal at My Biotech Life I am here to report a tremendous disservice done to all of us western hemispherians(is that even a word?) by the Portuguese.On the 20th of May in the Journal of Clinical Oncology an article was presented examining the BRCA2 rearrangements in 210 high risk cancer families. The rearrangement they described, occurs in 1/3 of all male breast cancers that they identified. Why the big deal? Well, only 7 rearrangements to date have been described in the BRCA2 gene. In addition these rearrangements are not picked up in point mutation sequencing. Which brings me to a very important point regarding genetic testing. No Test Gives a Yes or No Answer. These tests require skilled interpretation as well as counseling to evaluate for furth... Gene Sherpas: Personalized Medicine and You blogs http://www.medworm.com/rss/comments.php?id=687125 Thu, 24 May 2007 15:45:00 +0100 687125