MedWorm provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest medical blog items that have been tagged with 'cancer lung'. Sat, 03 Sep 2011 02:06:34 +0100 http://www.medworm.com/index.php?rid=5125976&cid=t_303864_155_f&fid=38412&url=http%3A%2F%2Fpathlabmed.typepad.com%2Fsurgical_pathology_and_la%2F2011%2F08%2Fwclc-2011-oral-presentations-squamous-cell-carcinoma.html This study involved a tissue microarray constructed from 568 patients with stage 1 NSCLC with detailed histopathological and clinical data.  SOX2 gene data was determined by FISH and SOX2 protein expression was assessed by IHC.  This data was correlated then with clinicopathological findings and OS and cancer-specific survival. Increased SOX2 gene amplification or polysomy was found in 4% of (17/429) evaluable samples but 16/17 (94%) were associated with non-ADC histology.  SOX2 protein expression was found in 48% of NSCLC and was associated with non-ADC histology (P<0.001): SOX2 expression was identified in 78% of SQC specimens (178/227) but only in 15% of ADC (29/191).  Further, SOX2 protein expression was significantly associated with high grade tumors, patien... The Daily Sign-Out blogs http://www.medworm.com/rss/comments.php?id=5125976 Fri, 12 Aug 2011 12:05:00 +0100 5125976 http://www.medworm.com/index.php?rid=5119013&cid=t_303864_155_f&fid=38412&url=http%3A%2F%2Fpathlabmed.typepad.com%2Fsurgical_pathology_and_la%2F2011%2F08%2Fwclc-2011-summary-from-plenary-session.html There were three themes from the Monday, July 3 plenery session at the 2011 14th World Conference on Lung Cancer.  First, the effect of smoking cessation on lung cancer incidence was discussed in relation to a recent study showing that women who smoke 20 cigarettes a day have a risk of developing lung cancer 30 times higher than non-smokers.  However, the study also showed that quitting before age 50 reduced the risk to sic times higher and quitting before age 40 reduced it to 1.2 times higher almost completely eliminating the risk from smoking. The second major theme discussed the shift from squamous cell carcinoma (SQC) to adenocarcinoma (ADC) as the most prevalent histologic type of lung cancer.  The development of cigarette filters was discussed as one reason for this... The Daily Sign-Out blogs http://www.medworm.com/rss/comments.php?id=5119013 Wed, 10 Aug 2011 20:30:00 +0100 5119013 http://www.medworm.com/index.php?rid=5008199&cid=t_303864_87_f&fid=39187&url=http%3A%2F%2Fgetbetterhealth.com%2Fcounter-intuitive-results-several-cancer-screening-tests-dont-improve-health-outcomes%2F2011.07.07 Nearly forty years ago, President Richard Nixon famously declared a “War on Cancer” by signing the National Cancer Act of 1971. Like the Manhattan Project, the Apollo program that was then landing men on the Moon, and the ongoing (and eventually successful) World Health Organization-led initiative to eradicate smallpox from the face of the Earth, the “War on Cancer” was envisioned as a massive, all-out research and treatment effort. We would bomb cancer into submission with powerful regimens of chemotherapy, experts promised, or, failing that, we would invest in early detection of cancers so that they could be more easily cured at earlier stages. It was in the spirit of the latter that the National Cancer Institute launched the Prostate, Lung, Colorectal, and Ovarian Cancer (PLCO) ... Better Health blogs http://www.medworm.com/rss/comments.php?id=5008199 Thu, 07 Jul 2011 12:00:19 +0100 5008199 http://www.medworm.com/index.php?rid=4842011&cid=t_303864_155_f&fid=38412&url=http%3A%2F%2Fpathlabmed.typepad.com%2Fsurgical_pathology_and_la%2F2011%2F05%2Fincidentalomas-revisited.html In this study, sarcoidosis was diagnosed by EBUS-FNA in 22% of patients and 2 patients developed lung cancer 2 years after initial finding. While I concur with the basic premise of the post (i.e. that one shouldn't jump into a full-blown diagnostic work-up of an incidental finding), I think we should also insist on developing evidence-based criteria for managing these types of findings such as, Fleishner criteria for lung nodules. (Source: The Daily Sign-Out) The Daily Sign-Out blogs http://www.medworm.com/rss/comments.php?id=4842011 Thu, 19 May 2011 11:17:00 +0100 4842011 http://www.medworm.com/index.php?rid=4795068&cid=t_303864_155_f&fid=38412&url=http%3A%2F%2Fpathlabmed.typepad.com%2Fsurgical_pathology_and_la%2F2011%2F05%2Fddr2-kinase-mutations-in-lung-squamous-cell-carcinoma.html Yes--you read that right! The journal Cancer Discovery reports in a publish ahead-of-print article (abstract)the discovery of mutations in the discoidin domain receptor 2 tyrosine kinase (DDR2) gene in a series of lung squamous cell carcinomas (SQC) that may identify a  potential therapeutic target similar to those described for lung adenocarcinomas.  Interestingly, DDR2 is a receptor kinase that normally binds collagen as its ligand and has been shown to promote cell migration, proliferation, and survival when activated by ligand binding and phosphorylation. While subtypes of lung adenocarcinoma (ADC) have been increasingly better defined and characterized on multiple levels with respect to identifying therapeutic targets/responses, minimal progress has been made with squamous... The Daily Sign-Out blogs http://www.medworm.com/rss/comments.php?id=4795068 Fri, 06 May 2011 16:40:35 +0100 4795068 http://www.medworm.com/index.php?rid=4684777&cid=t_303864_155_f&fid=38412&url=http%3A%2F%2Fpathlabmed.typepad.com%2Fsurgical_pathology_and_la%2F2011%2F04%2Faberrant-wnt1-and-beta-catenin-expression-in-nsclc.html This month's April 2011 Journal of Thoracic Oncology has an interesting paper by Xu and colleagues (abstract) that examines Wnt1 expression in non-small cell lung cancer (NSCLC) in relation to downstream Wnt signaling molecules, including beta-catenin, and correlates different marker expression with traditional clinicopathological parameters. This is an immunohistochemical study of a tissue microarray composed of 262 NSCLC resected specimens.    The authors define aberrant beta-catenin expression as: 1) decreased membranous pattern in less than 70% of tumor cells, 2) cytoplasmic pattern of expression, or 3) nuclear pattern of expression.  As expected, the majority of patients are stage 1 or 2 but nearly 36% of the study population are never-smokers--over 50% in ... The Daily Sign-Out blogs http://www.medworm.com/rss/comments.php?id=4684777 Tue, 05 Apr 2011 19:55:50 +0100 4684777 http://www.medworm.com/index.php?rid=4600724&cid=t_303864_131_f&fid=34989&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FGeneticsHealth%2F%7E3%2FTl43_02SqrE%2F photo: Thinkstock If you live anywhere around New York City, or have visited the area recently, you may have seen these new anti-smoking commercials that are part of the New York City Health Department’s campaign called: NYC Quits! Obviously, the ads are meant to shock and disturb us (and our loved ones) into never touching another cigarette again. And they sure as hell are shocking and disturbing. (Watch videos of both below.) So much so, that as soon as these emphysema sufferers and stroke victims come on the air, both my husband and I reach for the remote to hit the mute button or change the channel. Not because we’re callous human beings, but because we’re both lifelong non-smokers, so we’re not the target audience anyway. (Doubtless the NYC Health Department an... Genetics and Health blogs http://www.medworm.com/rss/comments.php?id=4600724 Wed, 16 Mar 2011 22:17:20 +0100 4600724 http://www.medworm.com/index.php?rid=4575213&cid=t_303864_136_f&fid=35283&url=http%3A%2F%2Fwww.cancer.org%2FAboutUs%2FDrLensBlog%2Fpost%2F2011%2F03%2F11%2FThe-Stories-Of-Cancer-When-Kill-Me-Is-Not-An-Option.aspx Cancer is emotional.  It is emotional for patients, families, friends and colleagues.  And there are few moments that are more touching to the human soul than hearing their stories recounting their journey, whether it is a success or unfortunately not.  These stories are frequently incredible accounts of human spirit.   Yesterday--in a room of 1200 cancer professionals at the annual meeting of the National Comprehensive Cancer Network in Hollywood, Florida--there were stories told that left no one untouched.  A moment when you could hear a pin drop, and see tears in the eyes of professionals who have seen so much heartache you would think they were used to it by now.   There was the football coach almost everyone knows who said that although he had been a lead... Dr. Len's Cancer Blog blogs http://www.medworm.com/rss/comments.php?id=4575213 Fri, 11 Mar 2011 16:18:00 +0100 4575213 http://www.medworm.com/index.php?rid=4326998&cid=t_303864_131_f&fid=34989&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FGeneticsHealth%2F%7E3%2FydV3A--zJng%2F photo: The New York Times In the New York Times series “Patient Voices,” real people who suffer from a slew of terrible physical and mental diseases and conditions – including bipolar disorder, migraines, lupus, multiple sclerosis, obsessive-compulsive disorder, Crohn’s disease, lung cancer, eating disorders, type 2 diabetes, and H.I.V. – talk via audio files about what it’s like to live and struggle with their health challenges. Well worth a listen. via The New York Times Post from: BlissTree Audio: Patients Talk About Living With Physical and Mental Illness (Source: Genetics and Health) Genetics and Health blogs http://www.medworm.com/rss/comments.php?id=4326998 Sun, 09 Jan 2011 18:08:38 +0100 4326998 http://www.medworm.com/index.php?rid=4275599&cid=t_303864_155_f&fid=38412&url=http%3A%2F%2Fpathlabmed.typepad.com%2Fsurgical_pathology_and_la%2F2010%2F12%2Foptimal-panel-for-differentiating-nsclc-in-small-specimens.html This study makes several practical points that can be nicely summarized as bullets: For ADC the most sensitive marker and best negative predictor is CK7: 93% sensitivity, 91% NPV. For ADC the most specific marker and best positive predictor is Napsin A: 94% specificity, 90% PPV. TTF-1 has similar specificity as Napsin A for ADC. For SQC the most sensitive marker and best negative predictor is p63: 84% sensitivity, 86% NPV. For SQC the most spepcific marker and best positive predictor is NTKR2 (a neurotrophic tyrosine kinase receptor, rarely used outside of research labs) but CK5/6 has a nearly identical specificity and PPV: about 95% specificity, about 95% PPV. No single marker is BOTH highly sensitive and specific for either ADC or SQC. The authors identified a 6-marker panel that inclu... The Daily Sign-Out blogs http://www.medworm.com/rss/comments.php?id=4275599 Tue, 21 Dec 2010 12:22:00 +0100 4275599 http://www.medworm.com/index.php?rid=4233364&cid=t_303864_136_f&fid=35283&url=http%3A%2F%2Fwww.cancer.org%2FAboutUs%2FDrLensBlog%2Fpost%2F2010%2F12%2F06%2FWill-An-Aspirin-A-Day-Keep-Cancer-Away-Maybe-But-Not-Just-Yet.aspx In this study, the researchers examined data from 8 previous studies that looked at aspirin as a means of reducing the chances of a vascular event, such as heart attack or stroke either as an initial preventive measure or a subsequent prevention strategy after someone had suffered an event.  They looked at studies that included patients who had been treated with daily aspirin for at least 4 years or longer.    They then examined the death certificates of those people in the trials who were thought to have died of cancer, and examined more detailed medical records of patients treated in three trials in the United Kingdom so they could have a longer term evaluation of aspirin's impact on deaths from cancer.   The researchers found 674 cancer deaths among 25,570 patients.&... Dr. Len's Cancer Blog blogs http://www.medworm.com/rss/comments.php?id=4233364 Mon, 06 Dec 2010 23:39:00 +0100 4233364 http://www.medworm.com/index.php?rid=4175981&cid=t_303864_155_f&fid=38412&url=http%3A%2F%2Fpathlabmed.typepad.com%2Fsurgical_pathology_and_la%2F2010%2F11%2Fassociation-between-egfr-mutations-and-ercc1-expression-in-nsclc.html Gandara and colleagues from UC Davis Cancer Center have published ahead-of-print on October 21, 2010 in Journal of Thoracic Oncology an interesting article examining the association between EGFR activating mutations and ERCC1 gene expression in NSCLC. NSCLC tumors that show EGFR activating mutations are also more likely to show low expression of ERCC1 mRNA levels according to this study.  This might explain (at least in part) the clinical observation that suggest enhanced efficacy of platinum-based chemotherapy in patients with EGFR-mutant NSCLCs. The authors performed microdissection of tumors from 1207 patients with NSCLC and analyzed EGFR mutation by allele-specific by PCR and ERCC1 mRNA expression by RT-PCR. Median ERCC1 expression was histology-related: adenocarcinoma (ADC... The Daily Sign-Out blogs http://www.medworm.com/rss/comments.php?id=4175981 Wed, 17 Nov 2010 12:04:00 +0100 4175981 http://www.medworm.com/index.php?rid=4172337&cid=t_303864_155_f&fid=38412&url=http%3A%2F%2Fpathlabmed.typepad.com%2Fsurgical_pathology_and_la%2F2010%2F11%2Fnovember-is-lung-cancer-awareness-month.html Sometimes I can't help but feel, especially as one with a steadfast interest in lung pathology (and lung cancer, in particular), that attention and funding for lung cancer research is the neglected ugly sister to breast cancer. Well, November is Lung Cancer Awareness Month! The numbers are staggering and worth considering: lung cancer is the most frequent cause of cancer deaths in the U.S. It is estimated in 2010 that about 222,000 men and women will be diagnosed with lung cancer and about 157,000 will die from the disease.  Compare these numbers with breast cancer (207,000 diagnosed, 40,000 deaths), prostate cancer (218,000 diagnosed, 32,000 deaths), and colon cancer (143,000 diagnosed, 53,000 deaths).  In other words, more people will die from lung cancer this year than b... The Daily Sign-Out blogs http://www.medworm.com/rss/comments.php?id=4172337 Tue, 16 Nov 2010 21:55:20 +0100 4172337 http://www.medworm.com/index.php?rid=4119749&cid=t_303864_155_f&fid=38412&url=http%3A%2F%2Fpathlabmed.typepad.com%2Fsurgical_pathology_and_la%2F2010%2F10%2Fgenetic-changes-and-risk-of-lung-cancer-and-copd.html Clipped an interesting item from FierceBiotech but haven't tracked down the main paper yet.  Specifically, it appears differences in a gene on chromosome 15 coding for a nicotine receptor contributes to nicotine addiction, which subsequently influences risk of COPD and lung cancer: Your DNA influences how much you smoke and whether you will develop lung cancer or chronic obstructive pulmonary disease (COPD), according to researchers led by Washington University School of Medicine in St. Louis and published in the journal Public Library of Science (PLoS) Genetics. In what they called the first large-scale effort to match genetics with smoking, lung cancer and COPD combined, researchers studied 38,000 smokers and found that two groups of gene variants on chromosome 15 influence ... The Daily Sign-Out blogs http://www.medworm.com/rss/comments.php?id=4119749 Tue, 26 Oct 2010 18:21:30 +0100 4119749 http://www.medworm.com/index.php?rid=3907795&cid=t_303864_155_f&fid=38412&url=http%3A%2F%2Fpathlabmed.typepad.com%2Fsurgical_pathology_and_la%2F2010%2F08%2Flung-adenocarcinoma-variants.html There are five common types of adenocarcinoma (actually I would say four since "mixed" doesn't seem to me a specific 'type") recognized in the WHO classification of lung cancer.  But this classification also includes five rare but distinctive variants: fetal adenocarcinoma, mucin-producing adencarcinomas (mucinous "colloid" adenocarcinoma, mucinous cystadenocarcinoma, and signet ring adenocarcinoma), and clear cell adenocarcinoma.  While rare to exceedingly rare as pure tumors, the variant patterns are important to be aware of because they occur much more commonly as a component of mixed type adenocarcinomas, are associated with particular clinicopathologic features, and often require the exclusion of a different primary site.  Anoth... The Daily Sign-Out blogs http://www.medworm.com/rss/comments.php?id=3907795 Thu, 26 Aug 2010 11:20:00 +0100 3907795 http://www.medworm.com/index.php?rid=3876597&cid=t_303864_87_f&fid=34872&url=http%3A%2F%2Fblisstree.com%2Ffeel%2F195608%2F People in China Don’t Know Smoking Risk: A government survey released today reveals that only one quarter of Chinese people believe that smoking cigarettes increases the risk of cancer. (via Reuters) Post from: BlissTree (Source: Healthbolt) Healthbolt blogs http://www.medworm.com/rss/comments.php?id=3876597 Tue, 17 Aug 2010 20:13:42 +0100 3876597 http://www.medworm.com/index.php?rid=3813213&cid=t_303864_155_f&fid=38412&url=http%3A%2F%2Fpathlabmed.typepad.com%2Fsurgical_pathology_and_la%2F2010%2F08%2Fnew-data-challenges-assumptions-about-smoking-and-lung-cancer.html Data presented at the recent 11th International Lung Cancer Congress challenges the commonly accepted notion that most lung cancer patients are current smokers or only recently quit after the onset of lung cancer-related symptoms.  A retrospective study of 626 lung cancer patients treated at a tertiary care center reported that 77% of patients had a smoking history--but only 14.7% were smoking at the time of diagnosis.  Moreover, 60% of the remaining patients with a smoking history had not smoked for a mean of 18 years--and the other 40% had stopped smoking within 10 years of diagnosis.  The research team was led by Dr. Cindy Mong from UCLA-David Geffen School of Medicine.In addition, a relationship between the time interval of smoking cessation and tumor histologic type ... The Daily Sign-Out blogs http://www.medworm.com/rss/comments.php?id=3813213 Mon, 02 Aug 2010 14:00:00 +0100 3813213 http://www.medworm.com/index.php?rid=3807528&cid=t_303864_155_f&fid=38412&url=http%3A%2F%2Fpathlabmed.typepad.com%2Fsurgical_pathology_and_la%2F2010%2F07%2Fmrna-subtypes-in-lung-squamous-cell-carcinoma.html With all the recent studies looking at various distinct histological and molecular subtypes in lung adenocarcinoma, lung squamous cell carcinoma has been somewhat neglected.  Pathologists have recognized variability in morphological appearances in squamous cell carcinomas and there is a wide range of clinical outcomes.  Although the recent WHO classification recognizes four uncommon histological variants, their biological and clinical significance is not clear.  Moreover, clinical differences between other less-defined morphological patterns are unknown.A paper published online on July 19, 2010 on Clinical Cancer Research by Wilkerson et al. from University of North Carolina sheds a new light of lung squamous cell carcinoma (abstract).  They describe four novel repr... The Daily Sign-Out blogs http://www.medworm.com/rss/comments.php?id=3807528 Sat, 31 Jul 2010 14:19:12 +0100 3807528 http://www.medworm.com/index.php?rid=3807395&cid=t_303864_87_f&fid=39187&url=http%3A%2F%2Fgetbetterhealth.com%2Fa-poem-about-an-ending%2F2010.07.31 She coughs and heaves a breathless goodbye into the bedside phone. Her lungs damp, bloated, sacked honeycomb wheeze with vanishing bees. The room of sensors and startling noise has not air to float upon. Morphine slakes a thirst for breathable sky and calms the panic within. The shame of living, of death smiling, savoring smoke and ash. Eyes closed she imagines her son, boy, man, precious evermore. Flowers. Beautiful white, red, and black from a husband who waits. Starstuff spinning in galaxies far, with summer lightning bugs. And then it is upon her, the moment, dreaded, practiced, boundless. We run through soft sands lit by moonlight, now tumbling under waves. All that matters doesn’t. And all that happens matters. The absence of pain and hunger the end of struggle and story mark an in... Better Health blogs http://www.medworm.com/rss/comments.php?id=3807395 Sat, 31 Jul 2010 14:00:06 +0100 3807395 http://www.medworm.com/index.php?rid=3767335&cid=t_303864_155_f&fid=38412&url=http%3A%2F%2Fpathlabmed.typepad.com%2Fsurgical_pathology_and_la%2F2010%2F07%2Fmucinous-bronchioloalveolar-carcinoma-of-lung-and-alk-mutation.html In this study, 96% of responders had adenocarcinoma histology--primarily signet ring morphology.This is surely a very exceptional case since mucinous ACa/BAC is a very distinctive histological subtype and has been also characterized at the molecular level as being associated with KRAS mutation.  The point is that histology is not a perfect predictor of potentially druggable molecular pathologies.  If targeted therapy is being contemplated in NSCLC, we should adopt a systematic approach to all NSCLC regardless of histology.  At this point, while we are identifying patients who may potentially benefit from targeted therapy, we are building a database that will allow a more full appreciation of the relationship between histological type and molecular pathology.Thanks t... The Daily Sign-Out blogs http://www.medworm.com/rss/comments.php?id=3767335 Tue, 20 Jul 2010 04:06:14 +0100 3767335 http://www.medworm.com/index.php?rid=3746686&cid=t_303864_87_f&fid=34872&url=http%3A%2F%2Fblisstree.com%2Ffeel%2F187949%2F Cancer Deaths Dropping: Death rates for cancer are on a constant downward slope, thanks to early detection, people quitting smoking, and better treatments. (via Web MD) Post from: BlissTree (Source: Healthbolt) Healthbolt blogs http://www.medworm.com/rss/comments.php?id=3746686 Fri, 09 Jul 2010 19:54:41 +0100 3746686 http://www.medworm.com/index.php?rid=3644739&cid=t_303864_87_f&fid=36050&url=http%3A%2F%2Fblisstree.com%2Flive%2Flung-cancer-rates-increasing-in-women%2F In the battle of the sexes, no one wants to win for “highest rate of lung cancer”, but women are slowly earning the title. Overall lung cancer rates and the rate among men have both gone down over the past three decades, but the rate of lung cancer in women has simultaneously increased, stumping doctors and researchers. Men still suffer a higher rate of lung cancer than women overall, but the chart below shows how the balance is slowly tipping. Researchers suspect that estrogen may play a role, possibly encouraging the growth of cancerous cells, but behaviors might also be a factor: While women typically start smoking later, they also take longer to quit. Though research on estrogen and cancer isn’t yet conclusive, ditching your cigarettes quick should be a top priority i... Breastfeeding 1-2-3 blogs http://www.medworm.com/rss/comments.php?id=3644739 Tue, 08 Jun 2010 21:41:54 +0100 3644739 http://www.medworm.com/index.php?rid=3607842&cid=t_303864_155_f&fid=38412&url=http%3A%2F%2Fpathlabmed.typepad.com%2Fsurgical_pathology_and_la%2F2010%2F05%2Fmutations-amok-in-lung-cancer.html A team from Genentech reports their findings in this week's Nature 465, 473-477 (27 May 2010) of direct tumor sequencing of a 51-year-old man with a 19-pack-year smoking history.  Note the greater than 50,000 mutations compared with paired "normal" lung. (egads!!!)  Not surprisingly, they found mutation of KRAS.  The magnitude and breadth of mutations is staggering and was surprising to the researchers.  Certainly give pause to ongoing efforts to identify oncogene-addicted tumors amenable to targeted therapy.excerpt from abstract:Here we present the complete sequences of a primary lung tumour (60× coverage) and adjacent normal tissue (46×). Comparing the two genomes, we identify a wide variety of somatic variations, including >50,000 high-confi... The Daily Sign-Out blogs http://www.medworm.com/rss/comments.php?id=3607842 Thu, 27 May 2010 20:30:00 +0100 3607842 http://www.medworm.com/index.php?rid=3508148&cid=t_303864_87_f&fid=36050&url=http%3A%2F%2Fblisstree.com%2Flive%2Flung-cancer-smoke-signals-women-still-at-high-risk%2F A new report features some scary stats about lung cancer, which is the leading cause of death among both men and women. Check this out: Lung cancer is the leading cause of cancer death in women, killing more women each year than breast and all gynecological cancers combined. Every day, nearly 300 women will be diagnosed with lung cancer and about 200 women will die of it. Lung cancer incidence in women has increased six-fold over the past 30 years. Twenty percent of women diagnosed with lung cancer today have never smoked. Report conducted by the Mary Horrigan Connors Center For Women’s Health and Gender Biology. photo: Thinkstock Post from: BlissTree Lung Cancer Smoke Signals: Women Still at High Risk (Source: Breastfeeding 1-2-3) Breastfeeding 1-2-3 blogs http://www.medworm.com/rss/comments.php?id=3508148 Tue, 27 Apr 2010 13:03:02 +0100 3508148 http://www.medworm.com/index.php?rid=3486999&cid=t_303864_87_f&fid=34865&url=http%3A%2F%2Fwww.thecancerblog.com%2F2010%2F04%2F20%2Fdid-you-get-cancer-from-your-parents%2F Filed under: PreventionSome cancers like breast, colon, prostate and lung cancer run in families. Mutated cancer-causing genes can be passed from parents to children. But family history accounts for only about 5 to 10 percent of most fatal cancers. Even those who have inherited a high-risk genetic mutation like the BRCA-1 or BRCA-2 genes for breast cancer, can protect themselves. Scientists have identified three types of genes that affect your cancer risk. They are oncogenes, which encourage cells to proliferate in excess; tumor suppressor genes, which normally stop cells from multiplying out of control, but which can become damaged and ineffective; and mismatch-repair genes, which normally help to repair mistakes in DNA, but which can be damaged, allowing mistakes to accumulate. Other ... The Cancer Blog blogs http://www.medworm.com/rss/comments.php?id=3486999 Mon, 19 Apr 2010 23:00:00 +0100 3486999 http://www.medworm.com/index.php?rid=2876378&cid=t_303864_155_f&fid=38412&url=http%3A%2F%2Fpathlabmed.typepad.com%2Fsurgical_pathology_and_la%2F2009%2F10%2Ftoo-many-sox-can-be-a-bad-thing.html Nature Genetics published a fascinating article online on October 4 by Bass et al. identifying SOX2 amplification in lung and esophageal squamous cell carcinomas (SqCC).  It is refreshing to read a good study of squamous cell carcinomas since there has been so much published recently on lung adenocarcinomas.This is a multi-institutional study that first examined 40 esophageal SqCC and 47 lung SqCC using SNP arrays to determine copy number changes and GISTIC (Genomic Identification of Significant Targets in Cancer) to score the significance of recurrent chromosomal gains and losses in order to identify peak regions likely to harbor tumor-driving genes.The most significant amplified peak in lung SqCC was at chromosome 3q26.33, found in 11/47 lung SqCC and 6/40 esophageal SqCC.  I... The Daily Sign-Out blogs http://www.medworm.com/rss/comments.php?id=2876378 Thu, 08 Oct 2009 20:42:45 +0100 2876378 http://www.medworm.com/index.php?rid=3808800&cid=t_303864_136_f&fid=35300&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Fmetastatic-liver-cancer%2F%7E3%2FqsgtVwKJX30%2F Christmas didn’t bring any joy this year. Nicole’s father passed away 2 weeks after Nicole’s last post featured at Give Nicole a hug: her father has stage iv lung cancer.   Give your condolences to Nicole in a comment.   Make an extra effort to keep in touch with care-givers who lost their loved ones to cancer.   For them [...] (Source: Metastatic liver cancer) Metastatic liver cancer blogs http://www.medworm.com/rss/comments.php?id=3808800 Fri, 02 Jan 2009 03:05:58 +0100 3808800 http://www.medworm.com/index.php?rid=1990572&cid=t_303864_86_f&fid=36669&url=http%3A%2F%2Ffadelibrary.wordpress.com%2F2008%2F11%2F26%2Fdefinitely-not-the-fifth-largest-city-in-france-new-nice-guidelines%2F Attention deficit hyperactivity disorder (ADHD) Osteoporosis- primary prevention Osteoporosis - secondary prevention Lung cancer (non-small cell) – erlotinib Electrically-stimulated intravesical chemotherapy for superficial bladder cancer Laparoscopic prostatectomy for benign prostatic obstruction Transabdominal artificial bowel sphincter implantation for faecal incontinence Posted in Clinical Governance, Clinical Guidelines, NHS   Tagged: Bladder Cancer, Clinical Guidelines, Drug Therapy, Faecal Incontinence, Hyperactivity, Lung Cancer, Osteoporosis, Surgery    (Source: Fade Library) Fade Library blogs http://www.medworm.com/rss/comments.php?id=1990572 Wed, 26 Nov 2008 07:15:04 +0100 1990572 http://www.medworm.com/index.php?rid=1677400&cid=t_303864_136_f&fid=36051&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FCancerCommentary%2F%7E3%2F9mB4u3uACE8%2F Last month, reports came out that Paul Newman has lung cancer. The ‘rumor’ was denied through his publicist. Earlier this month, the old actor has been spotted being pushed on a wheelchair — making the ‘lung cancer rumors’ resurface. Paul Newman was photographed in a wheelchair during a recent outing in New York following reports that the legendary actor has cancer. The photos, taken on July 7, show a woman pushing Newman in a wheelchair. Well…maybe he is sick. Due to lung cancer or just plain old age, who knows? Let us just wish him good health and peace. Tags: lung-cancer, Paul NewmanShare This (Source: Cancer Commentary) Cancer Commentary blogs http://www.medworm.com/rss/comments.php?id=1677400 Fri, 01 Aug 2008 06:05:18 +0100 1677400 http://www.medworm.com/index.php?rid=1485038&cid=t_303864_136_f&fid=36051&url=http%3A%2F%2Ffeeds.feedburner.com%2F%7Er%2Fb5media%2FCancerCommentary%2F%7E3%2F302568867%2F Increased intake of certain flavonoids in smokers may protect them by as much as 50 percent against lung cancer risk. Such were the findings of a UCLA study: Increasing intakes of epicatechin, catechins, and quercetin, found in tea and vegetables were associated with significant risk reductions. According to lead researcher Zuo-Feng Zhang from UCLA’s Jonsson Cancer Center: “What we found was extremely interesting, that several types of flavonoids are associated with a reduced risk of lung cancer among smokers. The findings were especially interesting because tobacco smoking is the major risk factor for lung cancer.” But still, tobacco smoke must be skipped altogether, because smoking remains a major factor for lung cancer risk. It just so interesting how smokers were prot... Cancer Commentary blogs http://www.medworm.com/rss/comments.php?id=1485038 Sun, 01 Jun 2008 22:00:19 +0100 1485038 http://www.medworm.com/index.php?rid=1472571&cid=t_303864_136_f&fid=35300&url=http%3A%2F%2Fwww.metastaticlivercancer.org%2F2008-05-28-cancer-treatment%2Fmetastatic-cancer-from-lung-to-liver-life-expectancy%2F Mom was asked this week what the metastatic cancer from lung to liver life expectancy was. Which made mom crying rather than answering the question. You need to know that mom being above 75 meets lots of elderly people when going to church, as the older generation sticks to their core habits. Now each mass is dedicated to somebody, and these last 2 weeks that was for father who died of metastatic liver cancer, his brother in law who died from kidney cancer and mom’s parents. Thinking back of what happened with her father having a "belly surgery" at his last days in hospital, we tend to believe he was suffering from colon cancer… So in a moment like this being asked what the life expectancy is of yet another secondary cancer patient made mom cry for what had happene... Metastatic liver cancer blogs http://www.medworm.com/rss/comments.php?id=1472571 Wed, 28 May 2008 02:53:28 +0100 1472571 http://www.medworm.com/index.php?rid=1458423&cid=t_303864_125_f&fid=34820&url=http%3A%2F%2Fwww.dentalblogs.com%2Farchives%2Fadministrator%2Fstudy-suggests-retaining-teeth-deters-cancer%2F In yet another development linking oral health to overall health, a report by researchers at Aichi Cancer Center in Nagoya and Nagoya University Graduate School of Medicine has connected tooth loss with cancer of the esophagus, lungs, and head and neck. While other studies have made similar correlations, this particular report is the largest of its kind. Speculations indicate that the bacteria related to tooth loss could influence development of these diseases. The report refers to the oral cavity as a “gateway between the external environment and the gastrointestinal tract.” Earlier reports linking periodontal disease to heart disease, stroke, diabetes complications, dementia, Alzheimer’s, and low birth weight reflect a similar premise. SOURCE: MedicalNewsToday (Source:... dental blog for dentists about dentistry blogs http://www.medworm.com/rss/comments.php?id=1458423 Wed, 21 May 2008 14:02:21 +0100 1458423 http://www.medworm.com/index.php?rid=1458591&cid=t_303864_131_f&fid=34989&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FGeneticsHealth%2F%7E3%2F294436566%2F (Carbon nanotube picture credit: www.bbc.co.uk/news) Carbon nanotubes - the epitome of the nanotechnology industry - have been found to trigger diseases similar to asbestos in research undertaken on mice including lesions and inflammation.  Use of asbestos triggered a pandemic of lung disease in the 20th Century. These tiny carbon molecules have remarkable properties that could be used for advanced electronics and materials including medical diagnostics.  They are already known to be incorporated into products such as tennis rackets, bicycle handlebars and baseball bats, where they are used because of their strength and light weight. In a series of experiments, researchers injected different lengths of multi-walled nanotubes - which comprise two to 50 concentric cylinders - into the abd... Genetics and Health blogs http://www.medworm.com/rss/comments.php?id=1458591 Tue, 20 May 2008 17:59:33 +0100 1458591 http://www.medworm.com/index.php?rid=1349623&cid=t_303864_131_f&fid=34989&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FGeneticsHealth%2F%7E3%2F264009127%2F A research team comprising scientists from MD Anderson, Johns Hopkins University and the Insitutute for Cancer Research and the University of Cambridge, UK have identified two inherited genetic variations (SNPs) on chromosome 15 associated with increased risk of lung cancer for smokers and former smokers. Individuals who have ever smoked and who have one or two copies of either of these SNPs have increased risks ranging from 28% to 81% of developing lung cancer. The findings are a major step forward in identifying those at high risk for non-small cell lung cancer and for understanding how smoking and genetic factors interact to cause the disease. The team’s findings might also provide support for a growing body of evidence suggesting that nicotine, long known as the prime addictive c... Genetics and Health blogs http://www.medworm.com/rss/comments.php?id=1349623 Fri, 04 Apr 2008 14:18:29 +0100 1349623 http://www.medworm.com/index.php?rid=1281071&cid=t_303864_136_f&fid=36051&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FCancerCommentary%2F%7E3%2F246202699%2F According to a study of more than 77,000 vitamin users , intake of some vitamin supplements do not protect against lung cancer, especially in smokers. Said the study’s author, Christopher G. Slatore, M.D., of the University of Washington, in Seattle: “Our study of supplemental multivitamins, vitamin C, vitamin E and folate did not show any evidence for a decreased risk of lung cancer. Indeed, increasing intake of supplemental vitamin E was associated with a slightly increased risk of lung cancer.” Such were the findings of Dr. Slatore and colleagues from selected prospective cohort of 77,126 men and women between 50 and 76 years of age in the Washington state VITAL (VITamins And Lifestyle) study. From the said population, the team determined their rate of developing lung ... Cancer Commentary blogs http://www.medworm.com/rss/comments.php?id=1281071 Wed, 05 Mar 2008 16:14:12 +0100 1281071 http://www.medworm.com/index.php?rid=1218317&cid=t_303864_136_f&fid=36051&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FCancerCommentary%2F%7E3%2F231509690%2F That may not be unheard of according to a clinical study of a team headed by the international Ludwig Institute for Cancer Research (LICR): What if we could prevent cancer recurrence for years after surgery by giving simple recall injections every two or three years? …has shown that a vaccine against a protein found in cancer cells produces an immune response that can be boosted and strengthened with additional vaccine shots. Patients with resected non-small cell lung cancer (NSCLC) were treated with this investigational agent, also known as an Antigen-Specific Cancer Immunotherapeutic (ASCI), in another clinical study conducted by GlaxoSmithKline. The results showed a reduction in risk of cancer recurrence in these patients, a finding that prompted GlaxoSmithKline to initiate the larges... Cancer Commentary blogs http://www.medworm.com/rss/comments.php?id=1218317 Fri, 08 Feb 2008 10:08:26 +0100 1218317 http://www.medworm.com/index.php?rid=1156938&cid=t_303864_107_f&fid=36585&url=http%3A%2F%2Ffeeds.feedburner.com%2F%7Er%2FHighlightHealth%2F%7E3%2F218040975%2F This article was published on Highlight HEALTH. Related articlesLack of Health Insurance Increases Risk of Cancer DeathDecrease in US Cancer DeathsThe Best of Highlight HEALTH 2007 - The Year in ReviewQuitWinLive - The Great American SmokeoutSmoking Duration vs. Intensity and the Impact on Lung Cancer Risk (Source: Highlight HEALTH) Highlight HEALTH blogs http://www.medworm.com/rss/comments.php?id=1156938 Thu, 17 Jan 2008 05:48:00 +0100 1156938 http://www.medworm.com/index.php?rid=1088765&cid=t_303864_136_f&fid=35300&url=http%3A%2F%2Fmetastaticlivercancer.org%2F2007-12-12-cancer-treatment%2Fcancer-support-from-garden-of-eden%2F Comment from "gardenofeden" at “Sad secondary liver cancer news, please give your support!” , with answer from Metastatic Liver Cancer. Pammy, My heart goes out to you. I too have a sister who has lung cancer that spread to her lymphnodes and now to her liver. She may not even make it through the holidays. Please take this big warm hug from me and may God give you the strength to come through this. A bug hug to Pammy and a big hug to Gardenofeden. A big hug to everybody Thanks Gardenofeden for commenting and adding an extra voice into the support. All the words cannot say what you must be going through, so we keep silent and give an extra hug. Whoever read this: feel free to give your feedback! Sooner or later you will read something that can set your mind more at ease ... Metastatic liver cancer blogs http://www.medworm.com/rss/comments.php?id=1088765 Wed, 12 Dec 2007 09:57:38 +0100 1088765 http://www.medworm.com/index.php?rid=1052346&cid=t_303864_136_f&fid=35300&url=http%3A%2F%2Fmetastaticlivercancer.org%2F2007-11-27-cancer-treatment%2Fwhat-kind-of-man-would-lie-to-his-own-wife-about-having-cancer%2F Do you tell everything to your partner? Or are you like me: when you have a bad day but your partner shows up all happy, do you join in his happiness? Or do you spoil the mood with the bad things that happened in your day? You would say: "gosh, it all depends actually"… That’s why I would be quite interested in "What kind of man would lie to his own wife about having cancer?". The author of this question will be one of the guests of the free reading series organized tomorrow November 28 (free of course!) at : Happy Ending Bar302 Broome Street between Forsyth and Eldridge, 212-334-9676Doors open at 7, show starts at 8 pm sharply! Did father lie about his cancer? After father passed away due to metastatic liver cancer, mom recalled and told us of one night ab... Metastatic liver cancer blogs http://www.medworm.com/rss/comments.php?id=1052346 Tue, 27 Nov 2007 02:48:27 +0100 1052346 http://www.medworm.com/index.php?rid=975027&cid=t_303864_107_f&fid=36585&url=http%3A%2F%2Ffeeds.feedburner.com%2F%7Er%2FHighlightHealth%2F%7E3%2F174153061%2F This article was published on Highlight HEALTH. (Source: Highlight HEALTH) Highlight HEALTH blogs http://www.medworm.com/rss/comments.php?id=975027 Wed, 24 Oct 2007 05:23:26 +0100 975027 http://www.medworm.com/index.php?rid=904577&cid=t_303864_136_f&fid=35300&url=http%3A%2F%2Fmetastaticlivercancer.org%2F2007-09-26-cancer-treatment%2Fstage-4-colon-cancer%2F Although most people already faint when they hear the word cancer, what you really don’t want to hear is a stage 4 cancer. Stage 4 colon cancer means that the colon cancer has spread to other organs, generally that’s to the liver but it might as well go to the lungs or any other organ. Most likely father’s metastatic liver cancer with unknown primary would have originated form colon cancer. But because a colonoscopy couldn’t be performed well due to a twist in the colon, we never heard the real answer to this question. Yet we couldn’t be bothered much whether father would have had colon cancer or lung cancer (as he used to smoke when he was younger) or any other cancer for that matter, as a stage 4 cancer normally has no cure. For sure there is not much hope... Metastatic liver cancer blogs http://www.medworm.com/rss/comments.php?id=904577 Wed, 26 Sep 2007 08:06:32 +0100 904577 http://www.medworm.com/index.php?rid=2510413&cid=t_303864_87_f&fid=34865&url=http%3A%2F%2Fwww.thecancerblog.com%2F2007%2F09%2F13%2Froutine-lung-cancer-screening-gets-thumbs-down%2F Filed under: Lung CancerLung cancer screening by using CT scans may not be the best thing to do, according to a recent report by the American College of Chest Physicians (ACCP).That group stated that, outside of research studies, studying lung cancer using CT technology is not worth the risk since it rarely (if at all) leads to reduced lung cancer deaths.The reason? Sounds to easy, but with CT tests only looking at lung cancer detection, actual survival rates were not looked at in many cases (and weren't affected anyway).Read | Permalink | Email this | Linking Blogs | Comments (Source: The Cancer Blog) The Cancer Blog blogs http://www.medworm.com/rss/comments.php?id=2510413 Wed, 12 Sep 2007 23:00:00 +0100 2510413 http://www.medworm.com/index.php?rid=836214&cid=t_303864_136_f&fid=36051&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FCancerCommentary%2F%7E3%2F150862530%2F In lung cancer patients, there is a decades-old method that has been used to predict survival and help determine whether a lung cancer patient will have surgery, chemotherapy or be treated at all. Now, there is a big overhaul of that old method that will allow for a formula called tumour staging –which is based on a tumour’s size, how far it has spread and other factors to predict a patient’s survival odds and to guide treatment. Under the new system -which classifies many tumours as more treatable than in the past – means more surgery or other aggressive therapy can be offered to thousand more lung cancer patients each year. The current system was developed from about 5,000 tumour samples from University of Texas M.D. Anderson Cancer Center in Houston decades ago - before ... Cancer Commentary blogs http://www.medworm.com/rss/comments.php?id=836214 Sat, 01 Sep 2007 09:07:01 +0100 836214 http://www.medworm.com/index.php?rid=828231&cid=t_303864_136_f&fid=35300&url=http%3A%2F%2Fmetastaticlivercancer.org%2F2007-08-29-cancer-treatment%2Fwhy-cancer-keeps-a-secret%2F There is a taboo when it comes to cancer: as if you did something wrong and … gosh, what is more bad than having cancer that you wouldn’t go in the open with it? But there is another reason I noticed now since Mom is above the knife and recovering in hospital. Her sister is visiting [...] (Source: Metastatic liver cancer) Metastatic liver cancer blogs http://www.medworm.com/rss/comments.php?id=828231 Wed, 29 Aug 2007 09:17:40 +0100 828231 http://www.medworm.com/index.php?rid=720460&cid=t_303864_136_f&fid=35300&url=http%3A%2F%2Fmetastaticlivercancer.org%2F2007-07-08-cancer-treatment%2Fwhat-does-spread-as-fast-as-cancer%2F Our Spreads like Cancer Squares! Father wanted to make sure that the voices of cancer would be heard. And we want to show these voices as fast as cancer spreads. So I need your help: do you have a cancer (awareness blog) do you have a loved ones with cancer Tell us about it in a comment, so [...] (Source: Metastatic liver cancer) Metastatic liver cancer blogs http://www.medworm.com/rss/comments.php?id=720460 Sun, 08 Jul 2007 02:54:45 +0100 720460 http://www.medworm.com/index.php?rid=713248&cid=t_303864_131_f&fid=35743&url=http%3A%2F%2Fthegenesherpa.blogspot.com%2F2007%2F07%2Fwhich-came-first-cancer-or-its.html Every now and again I like to throw out the old paradigms and put in some new. Geneticists love this......The So Called "Paradigm Shift"Back in 2005 this was done with Marfan's disease. It is an example I use to teach my students that what they may have learned is wrong. It is wrong because medical teaching is only built on science that has a very limited set of knowns and an immense set of unknowns.This paradigm shift is already in the making. The classical model of how a cancer develops is called the "two-hit" hypothesis. It states that in order to have uncontrolled growth of cells i.e. cancer, you need two hits to genes. Mostly you have to have at least 2 mutations. Sometimes you activate a gene by mutation and other times you may silence the genes. For the last 30 years the view of can... Gene Sherpas: Personalized Medicine and You blogs http://www.medworm.com/rss/comments.php?id=713248 Wed, 04 Jul 2007 01:20:00 +0100 713248 http://www.medworm.com/index.php?rid=620504&cid=t_303864_136_f&fid=35300&url=http%3A%2F%2Fmetastaticlivercancer.org%2F2007-05-16-cancer-treatment%2Fwhen-you-love-you-care%2F Why aren’t decision makers eradicating cancer? Because they don’t love people therefore don’t care. Let me tell you my cancer experience so far: Years ago my very best neighbour and friend died of lung cancer, yet it didn’t affect me much: people die don’t they? Father died of metastatic liver cancer and that had a huge impact [...] (Source: Metastatic liver cancer) Metastatic liver cancer blogs http://www.medworm.com/rss/comments.php?id=620504 Wed, 16 May 2007 02:21:53 +0100 620504