MedWorm provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest medical blog items that have been tagged with 'clinicaltrials'. Sat, 03 Sep 2011 02:28:39 +0100 http://www.medworm.com/index.php?rid=3816758&cid=t_107461_150_f&fid=35777&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FPharmalot%2F%7E3%2FmShjsSO3yyM%2F A new study finds that clinical trials funded by the pharmaceutical industry are more likely to report a positive outcome, but less likely to be published shortly after completion than trials funded by other sources, such as the federal government, non-profit groups or academia. Unlike previous studies on this topic, the researchers say their study broadens the debate because they made a point of examining 546 trials that were registered on ClinicalTrials.gov and involved five widely used classes of meds for treating depression, high cholesterol, high blood pressure, heartburn and schizophrenia. All of the trials occurred between 2000 and 2006. The study, which was published in The Annals of Internal Medicine, found 346 trials, or 63 percent, were primarily funded by industry, 74 or 14 per... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=3816758 Tue, 03 Aug 2010 14:50:41 +0100 3816758 http://www.medworm.com/index.php?rid=2984986&cid=t_107461_136_f&fid=37846&url=http%3A%2F%2Fhealthinfoispower.wordpress.com%2F2009%2F11%2F11%2Fnationwide-registry-to-match-study-volunteers-with-researchers%2F Individuals who want to participate in research studies can connect online with researchers nationwide through the first disease-neutral, volunteer recruitment registry.  ResearchMatch.org is a not-for-profit secure Web site, designed to provide people who are interested in participating in research the opportunity to be matched with studies that may be the right fit for them. NIH Announces [...] (Source: Libby's H*O*P*E*) Libby's H*O*P*E* blogs http://www.medworm.com/rss/comments.php?id=2984986 Thu, 12 Nov 2009 06:32:15 +0100 2984986 http://www.medworm.com/index.php?rid=1802936&cid=t_107461_150_f&fid=35777&url=http%3A%2F%2Ffeeds.feedburner.com%2F%7Er%2FPharmalot%2F%7E3%2F394244811%2F Less than 20 percent of registered clinical trials of cancer meds are eventually published in medical journals, according to a reviewy published online today by the The Oncologist medical journal. A search of the National Institutes of Health’s ClinicalTrials.gov web site identified 2,028 registered research studies of cancer treatments. Major medical journals, you may recall, require all studies considered for publication be registered at ClinicalTrials.gov or another publicly accessible database. And a subsequent search of the National Library of Medicine’s PubMed database showed that just 17.6 percent of the trials were eventually published in peer-reviewed medical journals. The publication rate was particularly low for “industry-sponsored” studies, such as tho... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=1802936 Tue, 16 Sep 2008 14:26:15 +0100 1802936 http://www.medworm.com/index.php?rid=1720553&cid=t_107461_150_f&fid=35777&url=http%3A%2F%2Ffeeds.feedburner.com%2F%7Er%2FPharmalot%2F%7E3%2F370003556%2F Since the International Committee of Medical Journal Editors began requiring clinical trials to be registered in a public trial registry at their outset as a condition of publication, ClinicalTrials.gov has become a useful repository of interesting data, Nature Reviews notes. And so a report examined all “industry-sponsored” Phase II through Phase IV studies on November 1, 2007, including trials that were first registered between October 2005 and September 2007. And what do we learn? Most registered trials were in oncology, followed by central nervous system disorders, cardiology, infectious diseases, endocrinology, and respiratory diseases. These six therapeutic areas accounted for 68 percent of 3,515l protocols and 74 percent of 94,135 sites. The number of registered trials ... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=1720553 Wed, 20 Aug 2008 14:12:36 +0100 1720553 http://www.medworm.com/index.php?rid=733623&cid=t_107461_87_f&fid=34865&url=http%3A%2F%2Fwww.thecancerblog.com%2F2007%2F07%2F13%2Fa-vaccine-for-prostate-cancer%2F Filed under: Prostate Cancer, Drug, Clinical Trials, ResearchThere's good news for prostate cancer patients who've had the disease spread to other parts of the body -- a new treatments, currently being tried out on hundreds of patients with promising results. The drug is called GVAX and it's referred to as a vaccine, although it doesn't work like most vaccines in the sense that it is administered after diagnosis and progression of the disease. According to this news story, GVAX works by adding prostate cancer cells to the body, but these new cells are unable to replicate. Several members of my family have battled prostate cancer to varying degrees of success, and I know that it's really widespread. So this is great news, and I hope GVAX is the miracle the prostate cancer is looking for. By... The Cancer Blog blogs http://www.medworm.com/rss/comments.php?id=733623 Fri, 13 Jul 2007 04:00:00 +0100 733623 http://www.medworm.com/index.php?rid=516398&cid=t_107461_87_f&fid=34867&url=http%3A%2F%2Fwww.thediabetesblog.com%2F2007%2F04%2F02%2Fpig-islets-10-years-and-counting%2F Filed under: Type 1, Childhood, Lifestyle, Research, Events, SupportIn 1996 a 41 year old male (a type 1 diabetic for 18 years) was injected with biocapsules containing pig islets to regulate his blood sugar level. The transplanted cells helped reduce the patient's insulin requirement by 34% for over a year, which provided better control. By 2005 the patient's glycated hemoglobin levels (HbA1c) remained lower than the pre-transplant levels. Ten years later, the patent contacted Living Cell Technologies to inform them that he believed the transplanted pig islets were still alive and well. After tests were conducted, it was concluded that the pig cells were (as he reported) still functioning. This proved that the LCT patented technology for xenotransplantation was effective. It allows the is... The Diabetes Blog blogs http://www.medworm.com/rss/comments.php?id=516398 Mon, 02 Apr 2007 04:00:00 +0100 516398 http://www.medworm.com/index.php?rid=509318&cid=t_107461_87_f&fid=34867&url=http%3A%2F%2Fwww.thediabetesblog.com%2F2007%2F03%2F29%2Faccidental-diabetes-drug%2F Filed under: Type 2, Adult Onset, Drugs, ResearchMuch like a roadblock, but with a fortuitous outcome -- an experimental heart drug didn't achieve the primary goal of a late-stage trial but it did dramatically reduce the risk patients would develop diabetes. The anti-oxidant, anti-inflammatory drug, the first of its kind, reduced the risk of developing diabetes by 64% and demonstrated a small but statistically significant reduction in blood sugar after 12 months. The study included data from 6,144-patients. The company believes this finding to be a serendipitous outcome, despite the initial shortcomings of the trial objective. They need to confirm it in a large clinical trial. The impressive diabetes results may come as a surprise to investors who have abandoned AtheroGenics or who have b... The Diabetes Blog blogs http://www.medworm.com/rss/comments.php?id=509318 Thu, 29 Mar 2007 04:00:00 +0100 509318 http://www.medworm.com/index.php?rid=503970&cid=t_107461_87_f&fid=34867&url=http%3A%2F%2Fwww.thediabetesblog.com%2F2007%2F03%2F27%2Fc-peptide-missing-in-action%2F Filed under: Type 1, Type 2, Childhood, Adult Onset, Lifestyle, Drugs, ResearchWhen treating diabetes, today's doctors focus on establishing blood glucose control, but often overlook the need to protect against common diabetic complications such as blindness, kidney damage, and nerve damage. The DCCT, even with a comprehensive treatment program, had a complication rate of approximately 40% of participants. People who do not have diabetes make insulin with C-peptide. Those of us diabetics who inject synthetic insulin do not get the C-peptide. When scientists began developing insulin - they weeded out the pieces of the amino acid chain they felt were insignificant in lowering blood glucose. Synthetic insulin was designed to reduce the dangerous buildup of excess sugar in the bloodstream. Uh ... The Diabetes Blog blogs http://www.medworm.com/rss/comments.php?id=503970 Tue, 27 Mar 2007 04:00:00 +0100 503970 http://www.medworm.com/index.php?rid=397037&cid=t_107461_86_f&fid=34466&url=http%3A%2F%2Fclinicalevidence.blogspot.com%2F2007%2F01%2Fclinical-trial-registration.html In an editorial by Drazen and Zarin in this week's NEJM, "Salvation by Registration," there's a brief tale about an author who submitted a paper to the journal, and the reported trial was incorrectly entered into clinicaltrials.gov - the paper was initially refused due to this issue, and it turned out that the trial's sponser was responsible for the incomplete record in the database. One of the co-authors inadvertently worked around this issue by creating a new, complete and accurate record, and the paper is included in this week's issue.The editorial points out the importance of a complete trial protocol submission to a public registry in compliance with the ICMJE initiative; they also point to the ineffectiveness of duplicate efforts on the part of the study sponsor and the study investi... Clinical Evidence, Searching Tidbits, and Other Minutiae blogs http://www.medworm.com/rss/comments.php?id=397037 Thu, 11 Jan 2007 22:18:00 +0100 397037