MedWorm provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest medical blog items that have been tagged with 'clopidogrel'. Sat, 03 Sep 2011 02:38:12 +0100 http://www.medworm.com/index.php?rid=3929410&cid=t_134610_131_f&fid=35743&url=http%3A%2F%2Fthegenesherpa.blogspot.com%2F2010%2F08%2Fplavix-and-2c19-brewhahhah.html Yes,I am a little slow Yes,It has been a long time. But,I am back. With a serious hankering to smash some studies. I already pooh pooh'd the Migraine SNP study on Twitter, but the Plavix stuff.....That deserves a blogpost. To quote a famous caridologist and friend "If Plavix really didn't work for 30% of patients, why don't we see more in-stent thrombosis?" Translation: Your science is nice, but how does it fly in the real world? I have to tell you, at first I couldn't answer. It was a great question. Do a full third of people have that severe failure? The obvious answer is NO. If 1/3 rethrombosed, we wouldn't be using Drug Eluting Stents.So what is the answer:Apparently a BMS (I.E. Plavix maker) funded study investigated thisWe hypothesized that the benefits of clopidogrel as compared wit... Gene Sherpas: Personalized Medicine and You blogs http://www.medworm.com/rss/comments.php?id=3929410 Tue, 31 Aug 2010 23:46:00 +0100 3929410 http://www.medworm.com/index.php?rid=3399107&cid=t_134610_131_f&fid=35743&url=http%3A%2F%2Fthegenesherpa.blogspot.com%2F2010%2F03%2Fpgx-in-dtcg-doesnt-stand-up-to-useful.html HT Don Rule today as well as the ENTIRE Pharmacogenomics Advisory Group that I am a proud member of.Don wrote this comment a few days ago"I was curious about what SNPs the DTC companies offer so I wrote a little applet (http://snpweb.cloudapp.net/#/PharmGKBSNPs) to compare them to the SNPs in PharmGKB. It turns out the the Cytochromes are particularly sparse."Well Don, you are correct. Even more so, as we began to review SNP data it became crystal clear on Monday.The reason I was pissed about 23andMe doing the CF testing is because they missed hundreds of potential carrier alleles. What was even more so angering when I realized, you could be "tested" by one of these DTCG companies for "Plavix Metabolism" and come up with the absolute wrong answer. Imagine that. Most people turn to DNA for ... Gene Sherpas: Personalized Medicine and You blogs http://www.medworm.com/rss/comments.php?id=3399107 Wed, 24 Mar 2010 11:38:00 +0100 3399107 http://www.medworm.com/index.php?rid=2553180&cid=t_134610_131_f&fid=35743&url=http%3A%2F%2Fthegenesherpa.blogspot.com%2F2009%2F06%2Fgreat-job-mike-2c19-meets-grade.html I was flipping through the internal medicine news yesterday when I saw a colleague. Mike Murray, Clinical Chief up at the Brigham who had given me some good advice re: being a fellow and academia...... He and a couple other internal medicine geneticists write a column called "Genetics in Your Practice" Which is a welcome addition to what my wife and I (Both Internists) believe is one of the best print publications out there for keeping ahead of the curve with IM and subspecialties....Well,Mike wrote about Plavix, which, as you know, I have been all over since the studies came out in January showing significant differences in outcomes clinically with patients who cannot activate Plavix. Why was I all over it? Because it had met some criteria which I think will define what a good PGx test is... Gene Sherpas: Personalized Medicine and You blogs http://www.medworm.com/rss/comments.php?id=2553180 Mon, 29 Jun 2009 11:57:00 +0100 2553180 http://www.medworm.com/index.php?rid=2249492&cid=t_134610_117_f&fid=36026&url=http%3A%2F%2Fwww.everydayhealth.com%2Fblog%2Fzimney-health-and-medical-news-you-can-use%2Fif-you-take-plavix-read-this-now%2F If you or someone you know takes Plavix (clopidogrel), which is an anticlotting medication (often referred to as a blood thinner), you should take note of recent findings suggesting a potential problem when it is taken along with other drugs known as proton pump inhibitors. Proton pump inhibitors (PPIs) are drugs that reduce stomach acid and they are often prescribed along with Plavix because it can irritate the stomach in some patients. The PPIs help to reduce the stomach irritation. But recent findings are suggesting that PPIs might reduce the effectiveness of Plavix, which could be a problem since Plavix is most often prescribed for people who are at risk of having a heart attack or stroke and if it didn’t work they could be at risk of serious problems. So if you do take Plavix and if... Dr. Z's Medical Report blogs http://www.medworm.com/rss/comments.php?id=2249492 Fri, 06 Mar 2009 21:47:47 +0100 2249492 http://www.medworm.com/index.php?rid=2234066&cid=t_134610_117_f&fid=36026&url=http%3A%2F%2Fwww.everydayhealth.com%2Fblog%2Fzimney-health-and-medical-news-you-can-use%2Fif-you-take-plavix-read-this-now%2F If you or someone you know takes Plavix (clopidogrel), which is an anticlotting medication (often referred to as a blood thinner), you should take note of recent findings suggesting a potential problem when it is taken along with other drugs known as proton pump inhibitors. Proton pump inhibitors (PPIs) are drugs that reduce stomach acid and they are often prescribed along with Plavix because it can irritate the stomach in some patients. The PPIs help to reduce the stomach irritation. But recent findings are suggesting that PPIs might reduce the effectiveness of Plavix, which could be a problem since Plavix is most often prescribed for people who are at risk of having a heart attack or stroke and if it didn’t work they could be at risk of serious problems. So if you do take Plavix and if... Dr. Z's Medical Report blogs http://www.medworm.com/rss/comments.php?id=2234066 Wed, 04 Mar 2009 20:01:33 +0100 2234066 http://www.medworm.com/index.php?rid=2183097&cid=t_134610_131_f&fid=35743&url=http%3A%2F%2Fthegenesherpa.blogspot.com%2F2009%2F02%2Fprasugrel-saves-clopidogrel.html You gotta love it. The other day I was talking to a pharma rep, yes I do speak with them.....and they were all excited about Effient (generic name Prasugrel). What are these medications and why was the Pharma Rep excited?Well, you see Plavix(generic name Clopidogrel) which is one of the top 3 selling medications in the world is given to people who have had a stroke or heart attack. This medication is given to prevent another heart attack or stroke......Also, this medication is given to people who have received stents in their coronary arteries. This is to prevent the stents from clogging up with platelets.......sort of a Drano in a pill so to speak.It is also given to people who are having an acute heart attack.These 2 medications are blood thinners. How do these thinners work? They block ... Gene Sherpas: Personalized Medicine and You blogs http://www.medworm.com/rss/comments.php?id=2183097 Thu, 12 Feb 2009 12:10:00 +0100 2183097 http://www.medworm.com/index.php?rid=1190043&cid=t_134610_97_f&fid=35050&url=http%3A%2F%2Ffeeds.feedburner.com%2F%7Er%2FPharmaGazette%2F%7E3%2F226123635%2Fsmall_doses_of_plavix_works_on_1.html A new study believes that it has demonstrated that small doses of Plavix (clopidogrel) can be beneficial to children under the age of two who have heart problems.Dr. Jennifer Li, a pediatric cardiologist at Duke University Medical Centerm, recruited 92 children with various heart problems that put them at high risk for developing blood clots. The majority of the children in the study had hypoplastic left heart syndrome, a condition which has a poorly functioning small ventricle. Others had floppy or imperfect heart valves and one child had Kawasaki disease.The children received either clopidogrel or a placebo. Those receiving the treatment of clopidogrel received one of four doses ranging in strength from .01 to .20 milligrams per kilogram of body weight. They received the treatment o... PharmaGazette blogs http://www.medworm.com/rss/comments.php?id=1190043 Tue, 29 Jan 2008 20:42:37 +0100 1190043 http://www.medworm.com/index.php?rid=757953&cid=t_134610_87_f&fid=34866&url=http%3A%2F%2Fwww.thecardioblog.com%2F2007%2F07%2F25%2Fblood-thinner-statin-combination-may-be-safe-after-all%2F Filed under: Research, DrugsWhen it comes to prescribing medicine to someone with more than one medical condition, I'm certain that physicians must be very careful to prescribe right combination of medicines and to be sure that those medicines don't interact with each other. Until recently, it was thought that when heart patients took the anti-clotting drug clopidogrel with a statin to lower their cholesterol, they increased their risk of a dangerous interaction. But recent studies have been leading researchers and heart doctors to believe that the danger isn't significant after all. This is a relief to patients and those who treat them, because many who need anti-clotting drugs also should be taking statins.To hear more about the study's specifics, read this article from HealthDay.Read&nb... The Cardio Blog blogs http://www.medworm.com/rss/comments.php?id=757953 Wed, 25 Jul 2007 04:00:00 +0100 757953