MedWorm provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest medical blog items that have been tagged with 'colorectal cancer'. Sat, 03 Sep 2011 02:02:38 +0100 http://www.medworm.com/index.php?rid=5008199&cid=t_121701_87_f&fid=39187&url=http%3A%2F%2Fgetbetterhealth.com%2Fcounter-intuitive-results-several-cancer-screening-tests-dont-improve-health-outcomes%2F2011.07.07 Nearly forty years ago, President Richard Nixon famously declared a “War on Cancer” by signing the National Cancer Act of 1971. Like the Manhattan Project, the Apollo program that was then landing men on the Moon, and the ongoing (and eventually successful) World Health Organization-led initiative to eradicate smallpox from the face of the Earth, the “War on Cancer” was envisioned as a massive, all-out research and treatment effort. We would bomb cancer into submission with powerful regimens of chemotherapy, experts promised, or, failing that, we would invest in early detection of cancers so that they could be more easily cured at earlier stages. It was in the spirit of the latter that the National Cancer Institute launched the Prostate, Lung, Colorectal, and Ovarian Cancer (PLCO) ... Better Health blogs http://www.medworm.com/rss/comments.php?id=5008199 Thu, 07 Jul 2011 12:00:19 +0100 5008199 http://www.medworm.com/index.php?rid=4759043&cid=t_121701_150_f&fid=35777&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FPharmalot%2F%7E3%2FF7d0dGHppWA%2F Top of the morning to you. Gray skies are hovering over the Pharmalot corporate campus, but our spirits remain sunny. And why not? This inspires us to trot out one of our favorite sayings, courtesy of the morning mayor: ‘Every brand new day should be unwrapped like a precious gift.’ So while you tug on the ribbon, here are a few items to get you started. Have a great day, everyone, and smile… Merck To Buy Back Up To $5 Billion In Stock (Reuters) Teva Resumes Manufacturing At California Site (Orange County Business Journal) J&J Agrees To Buy Synthes For $21.3 Billion (Bloomberg News) Supreme Court Skeptical About Vermont Data Mining Law (Bellingham Herald) Lupin May Wait To Sell Birth Control Pills In The US (Bloomberg News) Merck And Biogen Expand Facilities In North... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=4759043 Wed, 27 Apr 2011 11:54:02 +0100 4759043 http://www.medworm.com/index.php?rid=4709154&cid=t_121701_83_f&fid=34856&url=http%3A%2F%2Finsidesurgery.com%2F2011%2F04%2Flynch-syndrome-hereditary-nonpolyposis-colon-cancere%2F Pathophysiology 1) carcinoma usually arising in proximal (right) colon 2) one of the following criteria must be met for diagnosis – colorectal cancer occurring in at least two generations, patient less than 50 years old, three or greater relatives with colon cancer (at least 2 of which are first-degree relatives) Histology/Gross Pathology usually a poorly differentiated colon carcinoma Poorly differentiated right colon cancer - normal fern-like tissue is at upper right Associated Conditions increased incidence of ovarian cancer and endometrial cancer Biochemistry tumors have a high level of genomic instability (microsatellites) (Source: Inside Surgery) Inside Surgery blogs http://www.medworm.com/rss/comments.php?id=4709154 Thu, 14 Apr 2011 02:31:38 +0100 4709154 http://www.medworm.com/index.php?rid=4600538&cid=t_121701_87_f&fid=39187&url=http%3A%2F%2Fgetbetterhealth.com%2Fcolon-cancer-screening-guideline-truths-and-myths%2F2011.03.16 Colon cancer screening has a particular personal interest for me — one of my colleagues in residency training had her father die of colon cancer when she was a teenager. No one should lose a loved one to a disease that, when caught early, is often treatable. But for both men and women, colon cancer is the third most common cancer behind lung cancer and prostate cancer in men, and behind lung cancer and breast cancer in women, it’s the second most lethal. The problem is that patients are often confused about which test is the right one. Is it simply a stool test? Flexible sigmoidoscopy? Colonoscopy? Virtual colonoscopy? Isn’t there just a blood test that can be done? (No.) In simple terms, this is what you need to know: All men and women age 50 and older should be scr... Better Health blogs http://www.medworm.com/rss/comments.php?id=4600538 Wed, 16 Mar 2011 13:00:00 +0100 4600538 http://www.medworm.com/index.php?rid=4399770&cid=t_121701_136_f&fid=37846&url=http%3A%2F%2Fhealthinfoispower.wordpress.com%2F2011%2F01%2F25%2Foutside-the-box-the-rogosin-institute-is-fighting-cancer-with-cancer-cells-in-clinical-trials%2F Researchers at the Rogosin Institute are using cancer “macrobeads” to fight cancer.  Cancer cells in the beads secrete proteins which researchers believe could signal a patient’s cancer to stop growing, shrink or even die. The treatment is currently being tested in human clinical trials. Two groundbreaking preclinical studies demonstrate for the first time that encapsulated [...] (Source: Libby's H*O*P*E*) Libby's H*O*P*E* blogs http://www.medworm.com/rss/comments.php?id=4399770 Wed, 26 Jan 2011 05:36:17 +0100 4399770 http://www.medworm.com/index.php?rid=3943036&cid=t_121701_155_f&fid=38412&url=http%3A%2F%2Fpathlabmed.typepad.com%2Fsurgical_pathology_and_la%2F2010%2F09%2Fprognostic-factors-in-t1-colorectal-adenocarcinoma.html A frequently encountered specimen is the adenocarcinoma with submucosal invasion arising in a dysplastic adenomatous polyp or sessile lesion that has been resected endoscopically.  While much effort is directed at determining margin adequacy and depth of invasion, less attention has been given to other parameters that may be associated with risk of lymph node (LN) metastasis. Measuring the depth of invasion is frequnetly problematic given the morcellated nature of most specimens.  Generally, if the lesion is felt to be adequately excised, a formal colectomy may not necessarily be needed since the risk of LN metastasis in a T1 tumor is felt to be too low to warrent the morbidity of a colectomy. A recent article in the August 2010 Modern Pathology sought to detect patients at hig... The Daily Sign-Out blogs http://www.medworm.com/rss/comments.php?id=3943036 Tue, 07 Sep 2010 11:40:00 +0100 3943036 http://www.medworm.com/index.php?rid=3640953&cid=t_121701_86_f&fid=36669&url=http%3A%2F%2Ffadelibrary.wordpress.com%2F2010%2F06%2F08%2Fjournal-of-medical-screening-2010-volume-17-no-1%2F JJournal of Medical Screening 2010 (Volume 17 No 1) Contents Page Fade Fave: Endorsement by the primary care practitioner consistently improves participation in screening for colorectal cancer: a longitudinal analysis Fade Skinny:Investigates the effect of general practice (GP) and general practitioner (GPR) endorsement for faecal occult blood test (FOBT)-based screening on maintenance of participation in screening over four successive screening rounds. It finds that associating a GPR or medical practice of recent contact with an invitation to screen achieves better participation and re-participation than does an invitation from a centralized screening unit. Furthermore, enhanced participation can be achieved by practice endorsement alone without requiring actual GPR involvement. (NHS Athe... Fade Library blogs http://www.medworm.com/rss/comments.php?id=3640953 Tue, 08 Jun 2010 13:16:28 +0100 3640953 http://www.medworm.com/index.php?rid=3635697&cid=t_121701_86_f&fid=36669&url=http%3A%2F%2Ffadelibrary.wordpress.com%2F2010%2F06%2F07%2Fgut-2010-volume-59-number-5%2F Contents Page Fade Fave: Guidelines for colorectal cancer screening and surveillance in moderate and high risk groups (update from 2002) Fade Skinny: Provides updated guidance on the appropriateness, method and frequency of screening for people at moderate and high risk from colorectal cancer. This guidance provides some new recommendations for those with inflammatory bowel disease and for those at moderate risk resulting from a family history of colorectal cancer. (NHS Athens is required to access this article online) Filed under: Athens Password, E-Journals Tagged: Athens Password, Colorectal Cancer, Current Awareness, E-Journals, Mass Screening (Source: Fade Library) Fade Library blogs http://www.medworm.com/rss/comments.php?id=3635697 Mon, 07 Jun 2010 09:38:42 +0100 3635697 http://www.medworm.com/index.php?rid=3302396&cid=t_121701_111_f&fid=36048&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FAHeartyLife%2F%7E3%2FFs5n-F6Sz34%2F If you go for a colonoscopy to check out the health of your bowels (colon), it may be in your best interest to ensure the doctor who is performing the test is a gastroenterologist, a GI doctor. While general practitioners can and do perform some colonoscopies, they don’t have the formal training of the GI doctors and can easily miss something that may otherwise have been noted. According to a study published in the Clinical Gastroenterology and Hepatology, GI doctors who performed colonoscopies had a higher colorectal cancer detection rate than did other doctors. Researchers looked at 110,402 residents who lived in the province of Ontario, Canada, and who were 50 to 80 years old at the time of their colonoscopy. All had been told that their colonoscopy was negative, meaning nothing u... A Hearty Life blogs http://www.medworm.com/rss/comments.php?id=3302396 Tue, 23 Feb 2010 17:55:39 +0100 3302396 http://www.medworm.com/index.php?rid=3339766&cid=t_121701_136_f&fid=35300&url=http%3A%2F%2Fwww.metastaticlivercancer.org%2F2010-02-11-cancer-treatment%2Ferbitux-erbitux-head-and-neck-cancer%2F Jim’s son is now getting better thanks to his holistic cancer treatments and Erbitux. Erbitux isn’t chemotherapy but in stead are antibodies helping your body to fight the cancer. Pretty logical approach to cure cancer: not using a poisonous chemotherapy in the hope to kill the cancer without killing the person buy making sure your body has an extra advantage in fighting the cancer by "adding antibodies". What is Erbitux? Erbitux is a mouse/human monoclonal antibody – monoclonal meaning all of them are cloned or made originating from the same cell. It is an epidermal growth factor receptor inhibitor and given by intravenous infusion for treatment of metastatic colorectal cancer and Erbitux is also known to treat head and neck cancer. Jim’s son is now t... Metastatic liver cancer blogs http://www.medworm.com/rss/comments.php?id=3339766 Thu, 11 Feb 2010 15:04:57 +0100 3339766 http://www.medworm.com/index.php?rid=3246855&cid=t_121701_86_f&fid=36669&url=http%3A%2F%2Ffadelibrary.wordpress.com%2F2010%2F02%2F06%2Fjournal-of-medical-screening-2009-volume-16-no-4%2F Contents Page Fade Fave: Perceived barriers to flexible sigmoidoscopy screening for colorectal cancer among UK ethnic minority groups: a qualitative study Fade Skinny: Evidence from existing UK screening programmes indicates disparities in uptake rates between UK ethnic minorities and the white majority population. Looks at beliefs about bowel cancer, perceived barriers to the test and ideas about ways to increase uptake. Finds most barriers were shared by all ethnic groups but health educators should supplement approaches designed for the majority to incorporate the specific needs of individual minority groups to ensure equitable access. (NHS Athens is required to access this article online) Filed under: Athens Password, Current Awareness, E-Journals Tagged: Athens Password, Colorectal C... Fade Library blogs http://www.medworm.com/rss/comments.php?id=3246855 Sat, 06 Feb 2010 08:50:04 +0100 3246855 http://www.medworm.com/index.php?rid=3243758&cid=t_121701_87_f&fid=34872&url=http%3A%2F%2Fwww.blisstree.com%2Fhealthbolt%2Ftake-home-a-personal-colonoscopy-video%2F We may be entering a whole new world of home videos if researchers from Indiana University Hospital in the United States have their way. If you were offered the chance to take home a video of your very own colonoscopy, would you? Would you go as far as to pay for one? The researchers conducted a survey of patients who underwent colonoscopies to see if they would like a video and if they would be willing to pay for one. Currently, videos are done if a procedure is going to be used as a teaching tool, but otherwise, recording is not done. However, since the effectiveness of colonoscopies are one of the tests that depend on the skill of the practitioner, a number of suspicious lesions may be missed during the procedure if it is not recorded. It turned out that a majority of the respondents sa... Healthbolt blogs http://www.medworm.com/rss/comments.php?id=3243758 Fri, 05 Feb 2010 12:52:20 +0100 3243758 http://www.medworm.com/index.php?rid=3167477&cid=t_121701_155_f&fid=38412&url=http%3A%2F%2Fpathlabmed.typepad.com%2Fsurgical_pathology_and_la%2F2010%2F01%2Fnodal-staging-score-a-tool-to-assess-adequate-staging-of-node-negative-colon-cancer----g%25C3%25B6nen-et-al-27-36-6166----journa.html Gonen, Schrag and Weiser recently report a study of colorectal cancer patients from the 1994-2005 SEER database to quantify the likelihood that a node-negative patient is, in fact, node-negative.  This is an interesting alternative method of assessing adequate staging of CRC in contrast to the usual "one-size-fits-all" minimum lymph node criteria (namely, 12).  They have developed a "nodal staging score" (NSS) that expresses the probability of a patient being "true negative" and find that this score depends on the T stage.  Overall, the probability of missing a positive node that is actually present is 29.7% if only 5 nodes are examined; 20.0% if eight are examined; 13.6% if 12 nodes are examined.  However, for a NSS of 90% (that is, a ... The Daily Sign-Out blogs http://www.medworm.com/rss/comments.php?id=3167477 Tue, 12 Jan 2010 20:32:02 +0100 3167477 http://www.medworm.com/index.php?rid=3083204&cid=t_121701_155_f&fid=38412&url=http%3A%2F%2Fpathlabmed.typepad.com%2Fsurgical_pathology_and_la%2F2009%2F12%2Fleave-well-enough-alone.html The standard of care for treatment of mCRC has been surgical resection followed by adjuvant chemotherapy.  In patients presenting with symptomatic mCRC, palliative surgery is performed for bleeding, obstruction, or perforation, while in patients presenting with non-emergent symptoms and limited disease, surgery may be undertaken with a curative intent.  The role and value of surgery in patients with unresectable stage 4 colon cancer and a synchronous asymptomatic primary tumor is being currently investigated by the National Surgical Adjuvant Breast and Bowel Project in a prospective phase II study (NSABP C-10).  Current recommendations for treatment of mCRC are: Patients with evidence of significant obstruction, perforation, or uncontrolled bleeding shou... The Daily Sign-Out blogs http://www.medworm.com/rss/comments.php?id=3083204 Sun, 13 Dec 2009 16:02:12 +0100 3083204 http://www.medworm.com/index.php?rid=3067327&cid=t_121701_155_f&fid=38412&url=http%3A%2F%2Fpathlabmed.typepad.com%2Fsurgical_pathology_and_la%2F2009%2F12%2Fmore-recommendations-for-lymph-node-adequacy-in-crc.html The Dutch National Working Group on Gastrointestinal Cancers has recently released colorectal cancer guidelines which includes a recommendation of a minimum of 10 lymph nodes to establish a negative lymph node status.  At the same time, the group states that "determining the lymph node status of a patient requires evaluation as many lymph nodes as possible using conventional techniques." (emphasis mineThe discussion of this recommendation states that "no definitive criteria were found in the literature regarding the minimum number of examined lymph nodes.  There is no evidence to support 12 lymph nodes, as recommended by TNM." (emphasis mine)Furthermore, they specifically do not recommend using immunohistochemistry to detect metastases or pre-treatment of me... The Daily Sign-Out blogs http://www.medworm.com/rss/comments.php?id=3067327 Mon, 07 Dec 2009 19:56:40 +0100 3067327 http://www.medworm.com/index.php?rid=3059902&cid=t_121701_155_f&fid=38412&url=http%3A%2F%2Fpathlabmed.typepad.com%2Fsurgical_pathology_and_la%2F2009%2F12%2Fmicrornas-as-a-predictive-marker-for-stage-ii-crc.html This is an interesting abstract presented at the recent 2009 Association for Molecular Pathology annual meeting which is highlighted in Medscape.  Finding the magic markers that will predict which stage 2 CRC patients will progress without chemotherapy is an intense area of research, as is research into the importance of microRNAs in various diseases.This abstract by Dr. Elizabeth Mambo et al. from Asuragen, Inc. is a small case-matched paired study but demonstrates that 11 microRNAs could potentially be prognostic for CRC recurrence.  Interestingly, they found that most microRNAs associated with CRC recurrence were downregulated but microRNA-21 and microRNA-31 were significantly upregulated compared to tumor specimens from CRC stage 2 patients who did not experienc... The Daily Sign-Out blogs http://www.medworm.com/rss/comments.php?id=3059902 Sat, 05 Dec 2009 03:01:49 +0100 3059902 http://www.medworm.com/index.php?rid=2901846&cid=t_121701_155_f&fid=38412&url=http%3A%2F%2Fpathlabmed.typepad.com%2Fsurgical_pathology_and_la%2F2009%2F10%2Frecent-lecture-on-role-of-kras-mutation-in-management-of-colorectal-cancer.html I recently gave a Tumor Board presentation on the role of KRAS mutation testing in the management of colorectal cancer.  The PowerPoint file is attached for educational purposes.  I hope you will find it of interest.Download K-ras lecture upload (Source: The Daily Sign-Out) The Daily Sign-Out blogs http://www.medworm.com/rss/comments.php?id=2901846 Fri, 16 Oct 2009 22:16:21 +0100 2901846 http://www.medworm.com/index.php?rid=2630398&cid=t_121701_155_f&fid=38412&url=http%3A%2F%2Fpathlabmed.typepad.com%2Fsurgical_pathology_and_la%2F2009%2F07%2Fcolorectal-cancer-more-lymph-nodes-not-necessarily-better.html I pulled the following from ASCO Daily News.  I haven't read the full paper myself and, although not surprised by this study's results, I think this will likely be a good paper to use in discussions with surgical and oncologist colleagues.HealthDay (7/20, Thomas) reported, "More isn't necessarily better when it comes to surgically removing lymph nodes to diagnose late-stage colorectal cancer," according to a study published July 20 in the Archives of Surgery. The World Congress of Gastroenterology recommends removing "at least 12 lymph nodes during surgery for colorectal cancer," a standard that has been "widely adopted as a measure of quality in surgical practices."         That benchmark was also ... The Daily Sign-Out blogs http://www.medworm.com/rss/comments.php?id=2630398 Thu, 23 Jul 2009 04:32:35 +0100 2630398 http://www.medworm.com/index.php?rid=2630399&cid=t_121701_155_f&fid=38412&url=http%3A%2F%2Fpathlabmed.typepad.com%2Fsurgical_pathology_and_la%2F2009%2F07%2Ffda-changes-labeling-for-cetuximab-and-panitumumab.html Finally, the FDA announced labeling changes to the anti-EGFR MoAbs cetuximab and panitumumab to reflect the overwhelming evidence supporting the benefit to patients receiving these drugs only with wild-type KRAS (recent CAP Today article).Although still limited to patients with metastatic colorectal cancer, I suspect there will be more uptake of KRAS mutation testing since there was still some confusion out there on the "best" way to test for EGFR because of the delay of the FDA to change the labeling--months after NCCN and ASCO changed their guidelines.Pathologists, oncologists, and patients should inquire about which methodology is being used because there are some critical differences. (Source: The Daily Sign-Out) The Daily Sign-Out blogs http://www.medworm.com/rss/comments.php?id=2630399 Thu, 23 Jul 2009 01:44:56 +0100 2630399 http://www.medworm.com/index.php?rid=2553254&cid=t_121701_155_f&fid=38412&url=http%3A%2F%2Fpathlabmed.typepad.com%2Fsurgical_pathology_and_la%2F2009%2F06%2Fmore-asco-09-updates.html One interesting negative study presented at the recent ASCO meeting was results from the C-08 trial of bevacizumab (Avastin).  This was a trial of stage 2/3 colorectal cancer (CRC) patients randomized to receive either standard chemo or standard chemo plus BEV for 1 year.  Although the rationale for this trial BEV was the successful use of BEV in the setting of metastatic CRC, the results showed no benefit in the adjuvant setting.However, an intriguing observation is that there was a "real" albeit transient benefit for patients receiving the addition of BEV during the year that it was received (a shown by a statistically significant separation in survival curves during the first year of treatment--which suggests that perhaps longer administrations of BEV might provide... The Daily Sign-Out blogs http://www.medworm.com/rss/comments.php?id=2553254 Mon, 29 Jun 2009 14:13:03 +0100 2553254 http://www.medworm.com/index.php?rid=2463078&cid=t_121701_111_f&fid=36048&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FAHeartyLife%2F%7E3%2FxuV4wyW1fBo%2F Young adults in the United States are being diagnosed with more colorectal cancer today than years ago despite a decline that started in the mid-1980s. Screening played a large role in colorectal cancer prevention and detection, which helped lower the numbers. Colonoscopies can detect polyps, overgrowth of tissue, that can become cancerous. If they’re detected and removed through colonoscopy, that’s one less chance of developing the cancer. And, if colorectal cancer does occur, if it’s detected early enough, colorectal cancer has 90% cure rate. But, this is really only for people over 50 years old as regular colon screenings aren’t usually suggested for younger people who aren’t considered to be high risk. Now, however, according to an article published in the... A Hearty Life blogs http://www.medworm.com/rss/comments.php?id=2463078 Mon, 08 Jun 2009 10:29:08 +0100 2463078 http://www.medworm.com/index.php?rid=2447733&cid=t_121701_111_f&fid=36048&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FAHeartyLife%2F%7E3%2FCZHE1Q_cJ8w%2F Colorectal cancer is the fourth most common cancer in the United States . It’s also one of the most detectable and treatable of all, with up to a 90% cure rate if caught in the early stages. Most often, once a cancer starts showing symptoms, it’s advanced quite a bit. So, the best way to find early cancers is through proper screening. The way to find - and prevent - colorectal cancer is through screening colonoscopies. X-ray showing polyps A long tube (endoscope) with a camera on one end is inserted into your rectum and then advanced slowly into your bowel, checking for anything unusual. The images are sent to a screen where the doctor can see the bowel lining. If something is seen, using the scope, the doctor can usually remove a piece of tissue to have it examined. Colonoscop... A Hearty Life blogs http://www.medworm.com/rss/comments.php?id=2447733 Mon, 01 Jun 2009 11:18:59 +0100 2447733 http://www.medworm.com/index.php?rid=2593223&cid=t_121701_136_f&fid=35300&url=http%3A%2F%2Fwww.metastaticlivercancer.org%2F2009-05-08-cancer-treatment%2Fcolon-cancer-treatment-2%2F   All medical info and patients experiences related to colon cancer treatment in order to better follow the discussion between Lisa whose dad had colon cancer and Mag whose father underwent colon cancer surgery 2 weeks ago.   Read first what doctors can tell you about colon cancer treatments and read more below many cancer stories about patients and their loved ones needing to deal with colon cancer.   Notice that:   in a conventional medicine prognosis, the patient’s general health comes last  in all our cancer survival stories we stress on doing everything you can to improve your general health first!   Wikipedia also has a huge coverage about colorectal cancer.   Colon cancer treatments according to your doctor   Prognosis or chance of re... Metastatic liver cancer blogs http://www.medworm.com/rss/comments.php?id=2593223 Fri, 08 May 2009 05:41:32 +0100 2593223 http://www.medworm.com/index.php?rid=2390450&cid=t_121701_155_f&fid=38412&url=http%3A%2F%2Fpathlabmed.typepad.com%2Fsurgical_pathology_and_la%2F2009%2F05%2Fpetacc3-study-and-correlation-of-molecular-markers-with-stagespecific-prognosis.html The Pan-European Trials in Alimentary Tract Cancers (PETACC-3) is a large phase III randomized trial that yielded pathologic samples evaluable for IHC and molecular testing from 1404 patients with stage II/III cancer in a substudy to correlate various markers with stage-specific prognosis.  The markers evaluated included p53, SMAD4, thymidylate synthase, telomerase, MSI, 18q LOH, KRAS mutation, and BRAF mutation.The study compared 420 stage II patients and 984 stage III patients.  The most interesting finding from this substudy is strikingly different changes in marker expression between the two groups.  This suggests that stage II and stage III CRC develop through distinctly different molecular pathways and, thus, may represent different biological and clinico-pathologic... The Daily Sign-Out blogs http://www.medworm.com/rss/comments.php?id=2390450 Wed, 06 May 2009 20:32:37 +0100 2390450 http://www.medworm.com/index.php?rid=2390451&cid=t_121701_155_f&fid=38412&url=http%3A%2F%2Fpathlabmed.typepad.com%2Fsurgical_pathology_and_la%2F2009%2F05%2Ftumor-budding-in-colorectal-cancer.html Is assessment of tumor budding in colorectal cancer ready for inclusion in the CAP Cancer Checklist?Tumor budding can be defined as isolated or small clusters of invasive tumor cells at the invasive tumor front that invade a short distance into a desmoplastic stroma.  Although originally defined by Ueda et al. in the context of the desmoplastic stromal response in rectal carcinoma, this phenomenon has been studied in colon carcinoma as well.  Others studies looking at the immunoprofile of tumor budding have also been published in the last couple of years, e.g. expression of EpCAM (Gosens et al. Mod Pathol 2007;20:221-232).Several small Japanese studies published in the last year have examined the association of tumor budding with adverse prognosis.  One of the problems wi... The Daily Sign-Out blogs http://www.medworm.com/rss/comments.php?id=2390451 Tue, 05 May 2009 19:08:12 +0100 2390451 http://www.medworm.com/index.php?rid=2349513&cid=t_121701_136_f&fid=37846&url=http%3A%2F%2Fhealthinfoispower.wordpress.com%2F2009%2F04%2F19%2Ftumor-promoting-protein-cox-2-is-the-target-of-first-joint-symposium-between-aacr-asco%2F “An inflammatory protein implicated in a variety of cancers is the target of the first joint symposium between the nation’s two premier cancer research organizations.  The presidents of the American Association for Cancer Research (AACR) and the American Society of Clinical Oncology (ASCO) organized the session focused on the COX-2 enzyme and cancer treatment Monday [...] (Source: Libby's H*O*P*E*) Libby's H*O*P*E* blogs http://www.medworm.com/rss/comments.php?id=2349513 Mon, 20 Apr 2009 05:03:52 +0100 2349513 http://www.medworm.com/index.php?rid=2326621&cid=t_121701_136_f&fid=37846&url=http%3A%2F%2Fhealthinfoispower.wordpress.com%2F2009%2F04%2F01%2Fphrma-report-shows-record-number-of-development-drugs-to-treat-cancer-63-ovarian-cancer-203-solid-tumor-drugs-listed%2F “Responding to President Obama’s call for ‘a cure for cancer in our time,’ the Pharmaceutical Research and Manufacturers of America (PhRMA) delivered a new report today on medicines in the research pipeline for cancer. The report shows that America’s pharmaceutical research and biotechnology companies are testing a record 861 new cancer medicines and vaccines. The [...] (Source: Libby's H*O*P*E*) Libby's H*O*P*E* blogs http://www.medworm.com/rss/comments.php?id=2326621 Wed, 01 Apr 2009 21:06:11 +0100 2326621 http://www.medworm.com/index.php?rid=2107756&cid=t_121701_87_f&fid=34935&url=http%3A%2F%2Fmedicine.com.my%2Fwp%2F%3Fp%3D5866 strWebsiteID = window.document.location.toString();strSplitWeb = strWebsiteID.split("/")strWebsiteID = strSplitWeb[2];document.write(”“); from the Malaysian Medical Resources New Technique Encourages Extra Stem Cell Production, Colorectal Cancer Risk Lower Among Women Taking HRT, Physical Fitness Maintains Mental Fitness in Women (Source: Malaysian Medical Resources) Malaysian Medical Resources blogs http://www.medworm.com/rss/comments.php?id=2107756 Thu, 15 Jan 2009 05:00:00 +0100 2107756 http://www.medworm.com/index.php?rid=2078791&cid=t_121701_87_f&fid=35060&url=http%3A%2F%2Fwww.healthnewsblog.com%2Fcgi-bin%2Fhnblog.pl%3Fhnblog%3D1231081 The Washington Post reports that the colonoscopy is much better at detecting colorectal cancer on the left side of the colon than the right. The procedure does a good job of detecting early signs of disease on the left side of the colon, or large intestine, but is not as effective at spotting potential problems of the right side of the organ. This means a colonoscopy's success at preventing colorectal cancer deaths seems to lie with its ability to uncover so-called "left-sided" problems. "We did find that colonoscopies are effective -- that's the good news. It's still one of the best screening tests for any cancer that we have," said study author Dr. Nancy Baxter, a colorectal surgeon with St. Michael's Hospital in Toronto. "But it's not perfect," she added. "And it does not appear t... HealthNewsBlog.com blogs http://www.medworm.com/rss/comments.php?id=2078791 Wed, 31 Dec 2008 22:40:00 +0100 2078791 http://www.medworm.com/index.php?rid=1889028&cid=t_121701_131_f&fid=34989&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FGeneticsHealth%2F%7E3%2Fr8fMfElnjtQ%2F It’s the Sunday edition of Genetics and Health so let’s sum up some of the genetic research and news that came up this week. A grand rounds lecture "Molecular Genetics of Colorectal Cancer" by Vincent Yang presents an overview on the role of genes in colorectal carcinoma, and shares initial findings on a cell cycle modulator gene. The NY Times article, "Man Who Helped Set the Stage for Nobel-Winning Work Has Left Science" profiles Dr. Douglas C. Prasher, the scientist who provided the essential piece of evidence that helped the work of Nobel Price Chemistry winners Roger Y. Tsien and Martin Chalfie. You’ll be surprised to find out Dr. Prasher’s latest employment. A "pleasure" gene is behind an obese person’s insatiable desire t... Genetics and Health blogs http://www.medworm.com/rss/comments.php?id=1889028 Mon, 20 Oct 2008 03:22:05 +0100 1889028 http://www.medworm.com/index.php?rid=1806235&cid=t_121701_115_f&fid=34678&url=http%3A%2F%2Fwww.catscanman.net%2Fblog%2F2008%2F09%2Fct-in-colorectal-cancer-8%2F Note: This is a series of images of CT scan in the diagnosis, staging and therapeutic follow-up of colorectal cancers, which I prepared for a talk that I had to give to general practitioners. By ‘prepared’ I mean I had selected representative images and annotated them to show the abnormality to laymen. So this series is not going to be exhaustively informative or educative. I would suggest places like this and this for more information on colorectal cancers for health professionals and patients who stumble in here from search engines. Sigmoid Colon Coronal & oblique sagittal MPR images (above & below) show an ‘apple core‘ mass (pink oval in the image above & black arrows in the image below)  involving a short segment of the Sigmoid colon with severe irregular ... scan man's notes blogs http://www.medworm.com/rss/comments.php?id=1806235 Fri, 19 Sep 2008 02:30:42 +0100 1806235 http://www.medworm.com/index.php?rid=1794375&cid=t_121701_115_f&fid=34678&url=http%3A%2F%2Fwww.catscanman.net%2Fblog%2F2008%2F09%2Fct-in-colorectal-cancer-7%2F Note: This is a series of images of CT scan in the diagnosis, staging and therapeutic follow-up of colorectal cancers, which I prepared for a talk that I had to give to general practitioners. By ‘prepared’ I mean I had selected representative images and annotated them to show the abnormality to laymen. So this series is not going to be exhaustively informative or educative. I would suggest places like this and this for more information on colorectal cancers for health professionals and patients who stumble in here from search engines. Sigmoid Colon Mid-sagittal and oblique coronal MPR images show concentric wall thickening in a long segment of the Sigmoid colon (yellow arrows in the image above and within the pink oval in the image below) with severe irregular luminal narrowin... scan man's notes blogs http://www.medworm.com/rss/comments.php?id=1794375 Mon, 15 Sep 2008 18:35:19 +0100 1794375 http://www.medworm.com/index.php?rid=1788685&cid=t_121701_115_f&fid=34678&url=http%3A%2F%2Fwww.catscanman.net%2Fblog%2F2008%2F09%2Fct-in-colorectal-cancer-6%2F Note: This is a series of images of CT scan in the diagnosis, staging and therapeutic follow-up of colorectal cancers, which I prepared for a talk that I had to give to general practitioners. By ‘prepared’ I mean I had selected representative images and annotated them to show the abnormality to laymen. So this series is not going to be exhaustively informative or educative. I would suggest places like this and this for more information on colorectal cancers for health professionals and patients who stumble in here from search engines. Descending Colon Coronal & sagittal MPR images (above & below) from a plain CT scan with air-distended large bowel show an ‘apple core‘ mass (white arrows) in the proximal  Descending colon with luminal occlusion. Coronal MP... scan man's notes blogs http://www.medworm.com/rss/comments.php?id=1788685 Fri, 12 Sep 2008 18:35:52 +0100 1788685 http://www.medworm.com/index.php?rid=1782597&cid=t_121701_115_f&fid=34678&url=http%3A%2F%2Fwww.catscanman.net%2Fblog%2F2008%2F09%2Fct-in-colorectal-cancer-5%2F Note: This is a series of images of CT scan in the diagnosis, staging and therapeutic follow-up of colorectal cancers, which I prepared for a talk that I had to give to general practitioners. By ‘prepared’ I mean I had selected representative images and annotated them to show the abnormality to laymen. So this series is not going to be exhaustively informative or educative. I would suggest places like this and this for more information on colorectal cancers for health professionals and patients who stumble in here from search engines. Transverse Colon Oblique transverse MIP image showing a  mass with concentric wall thickening and ‘apple core‘ appearance (black arrows) in the left side of the Transverse colon with severe irregular luminal narrowing. Contrast enema... scan man's notes blogs http://www.medworm.com/rss/comments.php?id=1782597 Thu, 11 Sep 2008 09:12:18 +0100 1782597 http://www.medworm.com/index.php?rid=1711848&cid=t_121701_131_f&fid=35743&url=http%3A%2F%2Fthegenesherpa.blogspot.com%2F2008%2F08%2Fnew-brcathis-time-its-colon.html This is a fantastic review. I have been very careful trying to avoid hyping tests. I do this because we need validation and some evidence for use would be nice. The problem is that sometimes a test is so powerful that it should not be sat on. This was the case with the BRCA genes. Even in 1996 Francis Collins was warning about testing without really thinking out the consequences. From his 1996 article in the New England Journal of Medicine. The benefits of presymptomatic testing to determine susceptibility to common cancers such as those of the breast, ovary, colon, and prostate are potentially substantial. Nonetheless, it is critical that we create safeguards to ensure that the benefits of testing exceed the risks. The technical ability to perform tests for mutations should not be confuse... Gene Sherpas: Personalized Medicine and You blogs http://www.medworm.com/rss/comments.php?id=1711848 Mon, 18 Aug 2008 10:53:00 +0100 1711848 http://www.medworm.com/index.php?rid=1637996&cid=t_121701_136_f&fid=36051&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FCancerCommentary%2F%7E3%2F339122109%2F ImClone Systems, Inc.’s advanced colorectal cancer drug has now received regulatory approval in Japan. ERBITUX(R) (cetuximab) has received marketing authorization in Japan for use in treating patients with advanced or metastatic colorectal cancer (mCRC). Specifically, this approval allows for the use of ERBITUX to treat patients with epidermal growth factor receptor (EGFR)-positive, curatively unresectable (inoperable), advanced or recurrent CRC, and allows the use of ERBITUX plus irinotecan in second and further lines of mCRC. With this approval, ERBITUX is the first ever EGFR-targeted monoclonal antibody to be submitted for and receive marketing authorization in Japan. ERBITUX (cetuximab) is a monoclonal antibody (IgG1 Mab) designed to inhibit the function of a molecular structure ... Cancer Commentary blogs http://www.medworm.com/rss/comments.php?id=1637996 Fri, 18 Jul 2008 16:00:28 +0100 1637996 http://www.medworm.com/index.php?rid=1531832&cid=t_121701_136_f&fid=36051&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FCancerCommentary%2F%7E3%2F315349454%2F Okay…here goes another news on flavonols from tea, onions, beans and apples. As suggested by findings of a new U.S. study, increased intake of such flavonols may reduce risk of colorectal cancer by as much as 76 percent. Findings were published in this month’s Cancer Epidemiology Biomarkers & Prevention: Analysis of data from a randomised dietary intervention trial showed that the overall class of flavonoid compounds was not associated with a risk reduction, but flavonols - a sub-group of flavonoids, did significantly reduce risk. The study adds to a growing body of science linking increased consumption of flavonol-rich foods, such as fruit and vegetables, to risk reductions for a range of cancers, including lung, pancreatic, and breast cancer. Flavonols, a sub-group of fla... Cancer Commentary blogs http://www.medworm.com/rss/comments.php?id=1531832 Thu, 19 Jun 2008 11:10:14 +0100 1531832 http://www.medworm.com/index.php?rid=1406944&cid=t_121701_115_f&fid=34678&url=http%3A%2F%2Fwww.catscanman.net%2Fblog%2F%3Fp%3D328 Note: This is a series of images of CT scan in the diagnosis, staging and therapeutic follow-up of colorectal cancers, which I prepared for a talk that I had to give to general practitioners. By ‘prepared’ I mean I had selected representative images and annotated them to show the abnormality to laymen. So this series is not going to be exhaustively informative or educative. I would suggest places like this and this for more information on colorectal cancers for health professionals and patients who stumble in here from search engines. Hepatic Flexure Oblique coronal MPR image showing a large exophytic mass at the Hepatic Flexure of colon with mild circumferential wall thickening in the Ascending Colon. The ileo-caecal junction is normal. Multiple metastases are seen in the Liv... scan man's notes blogs http://www.medworm.com/rss/comments.php?id=1406944 Tue, 29 Apr 2008 15:05:07 +0100 1406944 http://www.medworm.com/index.php?rid=1349494&cid=t_121701_115_f&fid=34678&url=http%3A%2F%2Fwww.catscanman.net%2Fblog%2F%3Fp%3D319 Note: This is a series of images of CT scan in the diagnosis, staging and therapeutic follow-up of colorectal cancers, which I prepared for a talk that I had to give to general practitioners. By ‘prepared’ I mean I had selected representative images and annotated them to show the abnormality to laymen. So this series is not going to be exhaustively informative or educative. I would suggest places like this and this for more information on colorectal cancers for health professionals and patients who stumble in here from search engines. Caecum & Ascending Colon Coronal curved MPR image showing a circumferential ‘apple core‘ mass involving the Caecum and proximal Ascending Colon (black arrow). The ileo-caecal junction is involved with some wall thickening in a sho... scan man's notes blogs http://www.medworm.com/rss/comments.php?id=1349494 Fri, 04 Apr 2008 14:10:27 +0100 1349494 http://www.medworm.com/index.php?rid=1347330&cid=t_121701_115_f&fid=34678&url=http%3A%2F%2Fwww.catscanman.net%2Fblog%2F%3Fp%3D316 Note: This is a series of images of CT scan in the diagnosis, staging and therapeutic follow-up of colorectal cancers, which I prepared for a talk that I had to give to general practitioners. By ‘prepared’ I mean I had selected representative images and annotated them to show the abnormality to laymen. So this series is not going to be exhaustively informative or educative. I would suggest places like this and this for more information on colorectal cancers for health professionals and patients who stumble in here from search engines. Ascending Colon Coronal MPR1 image showing a circumferential ‘apple core‘ mass in the proximal Ascending Colon (yellow arrow). The following sagittal MIP1 image shows the same mass (yellow arrow). Both images show iodinated oral contr... scan man's notes blogs http://www.medworm.com/rss/comments.php?id=1347330 Thu, 03 Apr 2008 03:54:34 +0100 1347330 http://www.medworm.com/index.php?rid=1344193&cid=t_121701_115_f&fid=34678&url=http%3A%2F%2Fwww.catscanman.net%2Fblog%2F%3Fp%3D315 Note: My blogging is suffering. Partially because of a busy work schedule and more due to a sustained case of writer’s block. I am taking the easy way out by starting this series of posts on colorectal cancers. I have said it a few times before in my blog and it bears repeating that I usually refrain from posting anything overtly radiological as it seems too much like work. So this series is not going to be exhaustively informative or educative. I would suggest places like this and this for more information on colorectal cancers for health professionals and patients who stumble in here from search engines. It is just a series of images on CT scan in the diagnosis, staging and therapeutic follow-up of colorectal cancers. I had prepared a set of images from my collection for a talk tha... scan man's notes blogs http://www.medworm.com/rss/comments.php?id=1344193 Wed, 02 Apr 2008 08:42:29 +0100 1344193 http://www.medworm.com/index.php?rid=1329220&cid=t_121701_136_f&fid=36051&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FCancerCommentary%2F%7E3%2F258393662%2F Colorectal cancer - sometimes called (large) bowel cancer or simply colon cancer - seems to be in the air this week. Now that the month of March is nearly over and before I totally forget, let me quickly mention that this month is National Colorectal Cancer Awareness Month. According to CDC : March is National Colorectal Cancer Awareness Month. In 2004, a total of 145,083 cases of colorectal cancer were diagnosed in U.S. adults, and 53,580 adults died from this disease (1). Although regular colorectal cancer screening can reduce the incidence of and mortality from this disease, (2) approximately 40% of U.S. residents who should be screened for colorectal cancer have not been screened in accordance with national guidelines (3). Source: CDC press release. Tags: colorectal-cancer, March 2008,... Cancer Commentary blogs http://www.medworm.com/rss/comments.php?id=1329220 Wed, 26 Mar 2008 16:00:28 +0100 1329220 http://www.medworm.com/index.php?rid=1325547&cid=t_121701_117_f&fid=36026&url=http%3A%2F%2Fblog.healthtalk.com%2Fzimney%2Frevisiting-colon-cancer-myths%2F March is National Colorectal Cancer Awareness Month, so I thought I’d republish a posting from last year that helps dispel a few myths about this disease: 1- Colon cancer is primarily a disease of men. This is false. Colon cancer affects men and women equally, both in terms of diagnosis and death. Everyone must be aware of the risks of colon cancer. 2- Colon cancer will show signs or symptoms, so I don’t need to be screened. This is false. Most cases of colon cancer will not show any symptoms at all. And by the time colon cancer becomes symptomatic (change in stool, weight loss, pain, bleeding), the cancer is at an advanced stage. To avoid advanced colon cancer, you must undergo screening prior to the development of symptoms. 3- Colon cancer is a disease of the elderly, so I don&#8... Dr. Z's Medical Report blogs http://www.medworm.com/rss/comments.php?id=1325547 Tue, 25 Mar 2008 18:54:32 +0100 1325547 http://www.medworm.com/index.php?rid=1301914&cid=t_121701_136_f&fid=36051&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FCancerCommentary%2F%7E3%2F251076162%2F An allergic reaction to the cancer drug cetuximab has been found. Sometimes the reaction includes anaphylaxis, a life-threatening condition characterized by a drop in blood pressure, fainting, difficulty breathing, and wheezing. Now researchers funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, have discovered that specific pre-existing antibodies cause the severe reaction to the drug. Cetuximab is an immune-based therapy commonly used to treat persons diagnosed with head and neck cancer, or colon cancer, marketed as the popular brand Erbitux — a product of ImClone Systems Inc. and Bristol-Myers Squibb Company. Find more details from NIAD/NIH. Tags: allergic reaction, cancer-drug, cetuximab, colorectal-cancer, Erbit... Cancer Commentary blogs http://www.medworm.com/rss/comments.php?id=1301914 Fri, 14 Mar 2008 00:19:39 +0100 1301914 http://www.medworm.com/index.php?rid=1292193&cid=t_121701_87_f&fid=34825&url=http%3A%2F%2Fwww.wesleyjsmith.com%2Fblog%2F2008%2F03%2Fwhat-i-have-in-common-with-katie-couric.html I am not a big fan of Katie Couric--but we do have thing in common: We have both had colonoscopies. I bring this rather personal matter up because this is is National Colorectal Cancer Awareness Month. My father died of colon cancer and believe me, you don't want the disease, and if you get it, you want it caught early. Undergoing a colonoscopy can accomplish both goals by removing pre-cancerous growths and detecting cancer that has formed before it spreads.As readers of SHS wish they could forget, my procedure discovered a polyp which has by now been incinerated. For those who wish to go down memory lane, here are the details, and no, I won't post a picture of my colon here at SHS.But do get the procedure. It is painless. You won't even remember much of it because of the drugs. And it cou... Secondhand Smoke blogs http://www.medworm.com/rss/comments.php?id=1292193 Tue, 11 Mar 2008 03:36:00 +0100 1292193 http://www.medworm.com/index.php?rid=1212094&cid=t_121701_97_f&fid=35050&url=http%3A%2F%2Ffeeds.feedburner.com%2F%7Er%2FPharmaGazette%2F%7E3%2F230434278%2Froches_xeloda_gets_ec_approval.html The European Commission has approved Roche's oral chemotherapy Xeloda for treatment of metastatic colorectal cancer in combination with any chemotherapy with or without Avastin.The approval of the new indication will allow more patients that have colorectal cancer that has spread to be able to take advantage of the treatment. Pivotal studies demonstrated that Xeloda tablets provided patients with a more flexible treatment that delivered the same survival rates as previously standard chemotherapy treatments. Other studies have shown Xeloda to be more effective than other standard therapies."Colorectal cancer is a devastating disease and treatment options for patients have been limited," said Professor Jim Cassidy, Cancer Research UK Professor of Oncology and Chair of Medical O... PharmaGazette blogs http://www.medworm.com/rss/comments.php?id=1212094 Wed, 06 Feb 2008 17:00:44 +0100 1212094 http://www.medworm.com/index.php?rid=1187255&cid=t_121701_136_f&fid=36051&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FCancerCommentary%2F%7E3%2F225558102%2F Before it was an aspirin a day keeps the heart doctor away. Now, according to a study published in Gastroenterology (the official journal of the American Gastroenterological Association (AGA) Institute), the use of regular, long-term aspirin and non-steroidal anti-inflammatory drugs (NSAIDs) reduces the risk associated with colorectal cancer. According to Andrew T. Chan, MD, MPH, Massachusetts General Hospital and lead author of the study: “While the results of our study show that aspirin should not currently be recommended for the chemoprevention of colorectal cancer in a healthy population, there is a need for further studies to help identify for which patients the potential benefits outweigh the risks. We also need to improve our understanding of how aspirin works to prevent and i... Cancer Commentary blogs http://www.medworm.com/rss/comments.php?id=1187255 Wed, 30 Jan 2008 00:00:10 +0100 1187255 http://www.medworm.com/index.php?rid=1134201&cid=t_121701_107_f&fid=36585&url=http%3A%2F%2Ffeeds.feedburner.com%2F%7Er%2FHighlightHealth%2F%7E3%2F212653017%2F This article was published on Highlight HEALTH. (Source: Highlight HEALTH) Highlight HEALTH blogs http://www.medworm.com/rss/comments.php?id=1134201 Mon, 07 Jan 2008 16:03:22 +0100 1134201 http://www.medworm.com/index.php?rid=1048755&cid=t_121701_136_f&fid=36051&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FCancerCommentary%2F%7E3%2F190060954%2F According to a new study in mice (led by Zhenhua Liu from Tufts University), moderate deficiency of folate, riboflavin, and vitamins B6 and B12 together may promote the risk of DNA damage and increase the risk of colorectal cancers. The researchers, led by Zhenhua Liu from Tufts University, studied the Wnt pathway - a cellular signalling pathway linked to more than 85 per cent of colon cancers - and found that mild depletion of all four B vitamins was needed to promote the risk of tumour formation. Previously, studies have suggested that folate deficiency alone may promote the risk of colorectal cancer. The new research suggests a more complex interaction. However, the subject of folate and colorectal cancer is controversial, however, with some studies reporting that the B-vitamin may in f... Cancer Commentary blogs http://www.medworm.com/rss/comments.php?id=1048755 Sun, 25 Nov 2007 02:41:15 +0100 1048755 http://www.medworm.com/index.php?rid=1037901&cid=t_121701_136_f&fid=36051&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FCancerCommentary%2F%7E3%2F187705314%2F According to University of California - Irvine cancer researchers, low doses of freeze-dried grape powder inhibit genes linked to the development of sporadic colorectal cancer. Thereby suggesting that a grape-rich diet may help prevent the third most common form of cancer, one that kills more than a half a million people worldwide each year – colorectal cancer. Led by Dr. Randall Holcombe, director of clinical research at the Chao Family Comprehensive Cancer Center at UC Irvine, the study followed up on previous in vitro studies showing that resveratrol, a nutritional supplement derived from grape extract, blocks a cellular signaling pathway known as the Wnt pathway. The Wnt pathway has been linked to more than 85 percent of sporadic colon cancers, which is the most common form of colon ... Cancer Commentary blogs http://www.medworm.com/rss/comments.php?id=1037901 Tue, 20 Nov 2007 13:14:52 +0100 1037901 http://www.medworm.com/index.php?rid=1010678&cid=t_121701_136_f&fid=36051&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FCancerCommentary%2F%7E3%2F180972938%2F Curcumin has long been known for its anti-cancer properties. Curcumin is the yellowish component of turmeric that gives curry its flavor. I am not a fan of dishes that use curry. However, if cooked just right I may actually like it. My mother’s version of chicken curry (not too pungent but not bland either) is one of my favorites. Now, Japanese researchers reported that two molecular analogues of curcumin demonstrate even greater tumor suppressive properties. The team presented their findings from the first test of these molecules in a mouse model of colorectal cancer November 5 at the American Association for Cancer Research Centennial Conference on Translational Cancer Medicine. According to Tohoku University researcher Hiroyuki Shibata, M.D., curcumin is one of the most widely studie... Cancer Commentary blogs http://www.medworm.com/rss/comments.php?id=1010678 Wed, 07 Nov 2007 08:04:36 +0100 1010678 http://www.medworm.com/index.php?rid=938782&cid=t_121701_97_f&fid=35050&url=http%3A%2F%2Ffeeds.feedburner.com%2F%7Er%2FPharmaGazette%2F%7E3%2F167479276%2Fxeloda_capecitabine_better_tha.html Roche Holding AG's (OTC:RHHBY) Xeloda, which is the first FDA approved oral chemotherapy for metastatic breast and colorectal cancer, has proven to be more convenient and have fewer side effects than traditional chemotherapy.In a study of almost 2000 patients, research showed that 71% of patients were still alive after 5 years, after having been given Xeloda, as compared to 68% of those that received standard chemotherapy injections. The study also showed that patients treated with Xeloda spent 85% less time with their doctor or in hospitals and experienced fewer side effects."Standard chemotherapy can be incredibly disruptive to people's lives," said Prof Professor Chris Twelves of the University of Leeds, who led the research. "Patients visit hospital fiv... PharmaGazette blogs http://www.medworm.com/rss/comments.php?id=938782 Tue, 09 Oct 2007 16:00:16 +0100 938782 http://www.medworm.com/index.php?rid=921760&cid=t_121701_97_f&fid=35050&url=http%3A%2F%2Ffeeds.feedburner.com%2F%7Er%2FPharmaGazette%2F%7E3%2F164410536%2Froche_holding_ags_avastin_work_1.html Roche Holding (OTC:RHHBY) announced last week that new clinical data showed that Avastin improved the chances of removal of mestastatic lesions in people with colorectal cancer.Data showed that a large number of patients treated with Avastin combined with regular chemotherapy had their lesions completely removed. The trial was conducted with 1,965 patients with inoperable colorectal cancer. Of those in the trial 12% became eligible and underwent surgery and of the 12% 79% saw complete removal of the lesions."This outcome with Avastin is higher than has been previously seen in trials with other biologics/chemotherapy combinations," Roche said in a statement.Avastin is the first in a class of drugs that tries to starve tumors of their blood and nutrients. (Source: PharmaGazette) PharmaGazette blogs http://www.medworm.com/rss/comments.php?id=921760 Tue, 02 Oct 2007 23:00:42 +0100 921760 http://www.medworm.com/index.php?rid=795094&cid=t_121701_87_f&fid=34865&url=http%3A%2F%2Fwww.thecancerblog.com%2F2007%2F08%2F13%2Fpreventative-steps-could-save-100-000-lives%2F Filed under: Prevention, Research, Daily newsIncreased use of five preventative services would save more than 100,000 lives in the U.S. every year, according to Partnership for Prevention, a nonprofit health policy group.The services and behaviors are taking a low dose of aspirin every day for the prevention of heart disease, offering more services to help smokers quit, offering more colorectal and breast cancer screenings and offering flu shots for those over 50.The report also uncovered racial disparities in the use of preventative care. For example, Hispanic smokers are 55 percent less likely than whites to get help to quit smoking and Asian-Americans are the least likely to take aspirin and get screened for breast and colorectal cancer.The study found that 42,000 lives a year would be ... The Cancer Blog blogs http://www.medworm.com/rss/comments.php?id=795094 Mon, 13 Aug 2007 04:00:00 +0100 795094 http://www.medworm.com/index.php?rid=825748&cid=t_121701_136_f&fid=36051&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FCancerCommentary%2F%7E3%2F143470347%2F Dietary sources of the nutrient choline are red meat, eggs, poultry and dairy product. Choline is involved in the biochemical process known as one-carbon metabolism. As opposed to expected, diets high in choline have been found associated with an increased risk of some colorectal polyps – which can (but do not always) lead to colorectal cancer. Such were the findings of a study published online in the August 7 issue of the Journal of the National Cancer Institute: “Although our results were contrary to expectation based on choline’s role [in one-carbon metabolism], there is a potential biologic basis for the positive association that we observed…Once a tumor is initiated, growth into a detectable [polyp] depends in part on choline availability because choline is needed to make memb... Cancer Commentary blogs http://www.medworm.com/rss/comments.php?id=825748 Mon, 13 Aug 2007 00:05:57 +0100 825748 http://www.medworm.com/index.php?rid=644946&cid=t_121701_87_f&fid=34865&url=http%3A%2F%2Fwww.thecancerblog.com%2F2007%2F05%2F28%2Fvegetarians-have-a-reduced-risk-of-colorectal-cancer%2F Filed under: Colon and Rectal Cancer, Diets, Nutrition, Cancer prevention foodsThere are a number of benefits to a vegetarian diet and here's another one: Lifelong vegetarians have a reduced risk of developing colorectal cancer. The reason why is not made clear in the article but rather just that there's a link. So I wonder: What is it about a vegetarian diet that makes it healthier? Is it that vegetarians consumer more nutrients and antioxidants and less saturated fat? Does it have something to do with how non-meat food is digested? Is it because vegetarian diets are overall lower in calories and therefore less metabolizing means less harmful free agents in the body?I don't think this one study is a reason to quit eating meat, and although I'm not a big meat eater myself, I think that it ... The Cancer Blog blogs http://www.medworm.com/rss/comments.php?id=644946 Mon, 28 May 2007 04:00:00 +0100 644946