MedWorm provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest medical blog items that have been tagged with 'corticotropin'. Sat, 03 Sep 2011 03:00:46 +0100 http://www.medworm.com/index.php?rid=1883516&cid=t_178404_109_f&fid=35671&url=http%3A%2F%2Fwww.anxietyinsights.info%2Freceptor_finding_may_lead_to_more_potent_anxiety_depression.htm Researchers in the Laboratory of Structural Sciences at the independent research organization Van Andel Institute (VAI), have determined how the hormone corticotrophin-releasing factor (CRF) precisely binds to its receptor. This detailed structural information can help drug developers design new drugs for anxiety, depression, and related disorders. "There are a few drugs in development to treat anxiety, depression, and other conditions by targeting the cellular receptor that CRF binds to, but there are no drugs currently on the market," said VAI Distinguished Scientific Investigator Eric Xu, Ph.D. "There is a lot of interest in this receptor as a drug target, and we are the first to determine the structural details necessary to develop an ideal drug." CRF is a hormone and neurotransmitter ... Latest entries from www.anxietyinsights.info blogs http://www.medworm.com/rss/comments.php?id=1883516 Fri, 17 Oct 2008 08:17:00 +0100 1883516 http://www.medworm.com/index.php?rid=1739445&cid=t_178404_109_f&fid=35671&url=http%3A%2F%2Fwww.anxietyinsights.info%2Fresearch_points_to_new_anti_depressant_drug_target.htm The news about antidepressant medications over the past several years has been mixed. The bad news from large multicenter studies such as STAR*D is that current antidepressant medications are effective, but not as effective as one might hope. Thus, there is a significant need for new treatment mechanisms for depression. On that front, there has been mixed news as well. One of the most exciting new drugs to reach human clinical trials, the corticotrophin releasing factor-1 (CRF1) receptor blocker CP-316,311 did not work in a large clinical trial sponsored by Pfizer Pharmaceuticals. So, is it time to abandon CRF1 antagonists as antidepressants or should we revisit these agents from a new perspective? It is in this context that a new paper by AlexanDr Surget and colleagues, published in the A... Latest entries from www.anxietyinsights.info blogs http://www.medworm.com/rss/comments.php?id=1739445 Thu, 28 Aug 2008 11:31:00 +0100 1739445 http://www.medworm.com/index.php?rid=1376693&cid=t_178404_109_f&fid=34750&url=http%3A%2F%2Fpsychcentral.com%2Fblog%2Farchives%2F2008%2F04%2F16%2Fcp-316-311-fails-trials-pfizer%2F An experimental drug, called CP-316, 311 and made by Pfizer, was as effective as placebo (a sugar pill) in its initial clinical trials. At the interim analysis to determine efficacy, the researchers found the drug not to be working to help people with depression, and so the trial was terminated. CP-316, 311 is a selective nonpeptide antagonist of corticotropin-releasing hormone type 1 (CRH1) receptors. Hormone receptors? you might ask. Well, it turns out that the corticotropin-releasing hormone (CRH) system has been implicated as a possible contributing factor (or, perhaps, cause) of several psychiatric disorders, including major depressive disorder. Back to the drawing board for Pfizer. Reference: Binneman, B., Feltner, D., Kolluri, S., Shi, Y., Qiu, R. & Stiger, T. (2008). A 6-W... World of Psychology blogs http://www.medworm.com/rss/comments.php?id=1376693 Wed, 16 Apr 2008 12:03:15 +0100 1376693 http://www.medworm.com/index.php?rid=1303213&cid=t_178404_117_f&fid=34612&url=http%3A%2F%2Fwww.thedoctorweighsin.com%2Fjournal%2F2008%2F3%2F15%2Fcan-alcoholism-be-cured-without-aa.html By Dov Michaeli MD, Ph.D Alcoholism is a major public health problem. This we all know. But did you know that as alcoholism evolves, stress systems in the brain play an increasing role in motivating continued alcohol use and relapse. In other words, someone who is a moderate drinker will drink more if subjected to stress. And that, in turn would increase her sensitivity to stress, which would result in yet an additional increase in alcohol consumption, which in turn… you get the picture.The stress response Deficiency of a stress response is life threatening. For instance, in response to stress blood pressure goes up, heart rate increases and more blood is pumped into the brain and skeletal muscles. On the other hand, less blood is pumped into the GI tract or the kidneys. What’... The Doctor Weighs In blogs http://www.medworm.com/rss/comments.php?id=1303213 Fri, 14 Mar 2008 20:06:51 +0100 1303213 http://www.medworm.com/index.php?rid=1204756&cid=t_178404_109_f&fid=35671&url=http%3A%2F%2Fwww.anxietyinsights.info%2Fgene_variant_protects_some_abused_children_from_depression_i.htm Some forms of a gene that controls the body's response to stress hormones appear to protect adults who were abused in childhood from depression, psychiatrists have found. People who had been abused as children and who carried the most protective forms of the gene, called corticotropin-releasing hormone receptor one (CRHR1), had markedly lower measures of depression, compared with people with less protective forms, the researchers found in a recent study. The findings could guide doctors in finding new ways to treat depression in people who were abused as children, says senior author Kerry Ressler, MD, PhD, assistant professor of psychiatry and behavioral sciences at Emory University School of Medicine. "We know that childhood abuse and early life stress are among the strongest contributors... Latest entries from www.anxietyinsights.info blogs http://www.medworm.com/rss/comments.php?id=1204756 Tue, 05 Feb 2008 07:05:00 +0100 1204756