MedWorm provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest medical blog items that have been tagged with 'coumadin'. Sat, 03 Sep 2011 02:17:35 +0100 http://www.medworm.com/index.php?rid=5096204&cid=t_104841_87_f&fid=39187&url=http%3A%2F%2Fgetbetterhealth.com%2Fthe-perspective-of-the-clinical-trial-that-you-need-to-know%2F2011.08.04 There are big companies like Quintiles that run clinical trials around the world. There are local clinics that specialize in clinical trials and make a lot of money at it. There are, of course, pharmaceutical companies and device manufacturers who depend upon the results to gain marketing approval for new products. People in all those groups know a lot about trials. But the perspective that counts is the view from you and me – patients. Most of us do not enroll in clinical trials. We don’t want to get too up close and personal with anything “experimental.” And often our doctors never tell us about available trials anyway since it can be a lot of paperwork for them. Given that most people don’t enroll in trials and new science is delayed because of it and also because most people ... Better Health blogs http://www.medworm.com/rss/comments.php?id=5096204 Thu, 04 Aug 2011 18:00:38 +0100 5096204 http://www.medworm.com/index.php?rid=5077690&cid=t_104841_87_f&fid=39187&url=http%3A%2F%2Fgetbetterhealth.com%2Fthe-best-time-to-be-treated-for-a-dvt%2F2011.07.28 You know I am a cancer survivor – 15 years down the road from a leukemia diagnosis and enjoying a 10 year remission. So whenever something seems weird about my health it’s cancer coming back, right? Wrong! Just how wrong was proven last night. I am writing this from my hospital bed in Seattle. The first symptom of a possible problem came three days ago when I had soreness in my right calf. A pulled muscle? Maybe. But I had not noticed straining it. Back at the gym the next day I had soreness again but thought it was no big deal. Last night it was worse. It hurt some to walk. I got home and, after my wife and son were asleep, got ready for bed. I had a slight fever and then noticed the right calf was not only sore, but swollen and warm. Very strange. I’d never seen that before. Trying... Better Health blogs http://www.medworm.com/rss/comments.php?id=5077690 Thu, 28 Jul 2011 18:00:02 +0100 5077690 http://www.medworm.com/index.php?rid=4934484&cid=t_104841_113_f&fid=39278&url=http%3A%2F%2Fblogsite.mdbuyline.com%2F%3Fp%3D282 A blood coagulation test (prothrombin time test) that’s as easy to use as a home glucose meter and cheaper?  Wow!  Over 10% of all adverse drug events ending in a hospital stay are associated with blood thinners.  Because of this, regular monitoring is recommended to ensure the desired effect.  Unfortunately, the current technology is either costly or must be performed by qualified technicians. Currently, there are several point-of-care tests on the market, but the cost of the consumable test strips make it more expensive than laboratory testing.  However, the SmartStrip mimics “lab on a chip” technology but instead of fluidics, it’s based on microelectromechanical systems (MEMS) placed on a disposable test strip.  The result is a low-cost test that can be performed in minute... MD Buyline blogs http://www.medworm.com/rss/comments.php?id=4934484 Tue, 14 Jun 2011 13:39:53 +0100 4934484 http://www.medworm.com/index.php?rid=4780488&cid=t_104841_150_f&fid=35777&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FPharmalot%2F%7E3%2FGuogHFPFGkk%2F Good morning, everyone, and nice to see you again. A sunny day is unfolding here on the Pharmalot corporate campus, where we hope we have solved our recent tech problems. We appreciate your patience. Meanwhile, we are brewing the usual cup of stimulation - our flavor today is Mocha Nut Fudge - and perusing the news of the world. Let us know if you hear something interesting. And, of course, have a productive and rewarding day… Pfizer Earnings Rise On Lower Costs (Associated Press) Novartis CEO Not Thrilled With Health Care Reform (Fortune) Shanghai Pharma Raises $2.2B, Investors Include Pfizer (Bloomberg News) Could Chemicals In Wine Improve Stent Performance? (Health Day) Teva To Buy Japanese Generic Drugmaker (Globes) FDA Approves Boehringer/Lilly Diabetes Drug (Pharma Times) Parex... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=4780488 Tue, 03 May 2011 12:02:39 +0100 4780488 http://www.medworm.com/index.php?rid=4200564&cid=t_104841_87_f&fid=39187&url=http%3A%2F%2Fgetbetterhealth.com%2Fimproving-health-for-older-adults%2F2010.11.24 New clinical trials and published research are giving us information on how to improve health in elderly patients. Here are some brief points from the Cleveland Journal of Medicine that were surprising to me: – Each year 30 percent of people age 65 or older fall and sustain serious injuries so preventing falls and fractures is important. Vitamin D prevents both falls and fractures, but mega doses of Vitamin D (50,000 mg) might cause more falls. A better dose is 1,000mg a day in people who consume a low-calcium diet.  – Exercise boosts the effect of influenza vaccine. – The benefits of dialysis in older patients is uncertain, as it does not improve  function in people over age 80. We don’t even know if it improves survival. Older patients who receive dialysis... Better Health blogs http://www.medworm.com/rss/comments.php?id=4200564 Wed, 24 Nov 2010 21:00:00 +0100 4200564 http://www.medworm.com/index.php?rid=3750277&cid=t_104841_150_f&fid=35777&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FPharmalot%2F%7E3%2FJRV_5GQ4Oyc%2F Hello, everyone. Nice to see you again. Hope your week is going well so far. Meanwhile, another busy day lies ahead, especially as the FDA panel meeting gets under way to review Avandia. So let’s get started with a cup of stimulation and some interesting tidbits to help you along. Have a good one and stay in touch… Vivus Diet Drug Faces FDA Skepticism (Associated Press) Merck Starts Work On New Plant In China (People’s Daily) Lawsuits May Reveal More Avandia Data (Reuters) Lilly To Cut 170 Manufacturing Jobs (Indianapolis Business Journal) Global CSO Market To Hit $6.5B By 2015 (OutsourcingPharma) Clinuvel Drug Offers Relief From Sensititivity To Light (Bloomberg News) Latisse Faces Patent Challenge (The Wall Street Journal) Bristol-Myers Starts Recall Of Coumadin (Assoc... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=3750277 Tue, 13 Jul 2010 12:03:03 +0100 3750277 http://www.medworm.com/index.php?rid=3588842&cid=t_104841_87_f&fid=34872&url=http%3A%2F%2Fblisstree.com%2Ffeel%2F5-supplement-prescription-interactions-you-want-to-avoid-from-our-hunky-naturopath%2F All you supplement-takers and prescription-users, listen up: We’re all for tapping into your inner mixologist, but keep it to the cocktails. Blisstree’s resident hot naturopathic doctor, John Dempster, gave us the heads up about some dangerous supplement-prescription drug mixes that you may want to avoid. Check out the top five risky mixtures: 1. Milk Thistle and Birth Control Pills Milk Thistle, a powerful liver tonifier and popular detox supplement, may actually flush external hormones through the body along with last night’s cocktail. It has the potential to increase the clearance of external hormones – like the trusty Pill. While the risk is small, it still exists. Thus, a quick reminder for those self-prescribing liver cleanses to consult with a health care profess... Healthbolt blogs http://www.medworm.com/rss/comments.php?id=3588842 Fri, 21 May 2010 15:09:52 +0100 3588842 http://www.medworm.com/index.php?rid=1985163&cid=t_104841_150_f&fid=35777&url=http%3A%2F%2Ffeeds.feedburner.com%2F%7Er%2FPharmalot%2F%7E3%2F464176762%2F A group of researchers has assembled a list of 14 widely prescribed meds that are most urgently in need of additional study to determine their safety and effectiveness for off-label usage. As it so happens, antidepressants and antipsychotics are the most prominent types of drugs on the list, which specifically targets meds that are widely used off-label without proper scientific backing. At the top was AstraZeneca’s Seroquel, which yielded the highest off-label rate with limited evidence (76 percent of all uses). The pill also had features that raised additional concerns, including its high cost at $207 per prescription, heavy marketing and the presence of a “black-box” warning from the FDA, according to Randall Stafford, associate professor of medicine at the Stanford Preventio... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=1985163 Mon, 24 Nov 2008 18:55:44 +0100 1985163 http://www.medworm.com/index.php?rid=1616418&cid=t_104841_131_f&fid=35743&url=http%3A%2F%2Fthegenesherpa.blogspot.com%2F2008%2F07%2Fnew-gene-in-atrial-fibrillation.html Did anyone see the New England Journal of Medicine? They published an article on a new gene involved in atrial fibrillation. Don't know what A-Fib is? You have 4 Chambers in your heart.....the top 2 are called atria.....Atrial fibrillation can put you at risk for heart failure, heart attack and stroke.The last of these is the most ominous. This is one of the major reasons people take Warfarin. Which BTW, can have up to 45% of your metabolism tested for by genetic analysis of CYP 2C9 and VKORC1....And recent studies support its use.You can get your testing through DNADirect......even if your physician says there is no reason to test for it(They are dead wrong).....Some physician with the company will order it.....The question is, "Whose responsibility is it to tell results to the doctor who... Gene Sherpas: Personalized Medicine and You blogs http://www.medworm.com/rss/comments.php?id=1616418 Fri, 11 Jul 2008 00:53:00 +0100 1616418 http://www.medworm.com/index.php?rid=1593999&cid=t_104841_131_f&fid=35743&url=http%3A%2F%2Fthegenesherpa.blogspot.com%2F2008%2F07%2Flittle-story.html I want to wish everyone in the US a happy 4th of July. The fateful day took tremendous amounts of courage to stand up against status quo. Our Founding Fathers risked life and limb of not only themselves, but also their families. They would not stand for the tyranny and taxation that was levied upon them.Too bad our medical community isn't as courageous.I want to tell you a story. I was a resident at the time.JT was a 16 year old boy who had just been diagnosed with ulcerative colitis. It is an inflammatory condition of the bowel. He had been having episodes of horrible diarrhea and when he received the diagnosis he was started on a medication called 6-MP. If you must know, I was training in Internal Medicine at the time. Prior to this I trained in pediatrics......You see, in pediatrics bef... Gene Sherpas: Personalized Medicine and You blogs http://www.medworm.com/rss/comments.php?id=1593999 Mon, 07 Jul 2008 11:21:00 +0100 1593999 http://www.medworm.com/index.php?rid=1556680&cid=t_104841_107_f&fid=36585&url=http%3A%2F%2Ffeeds.feedburner.com%2F%7Er%2FHighlightHEALTH%2F%7E3%2F322982346%2F This article was published on Highlight HEALTH. Related articlesGenomic Medicine: An Educational Resource from Helix HealthMore Education Decreases the Risk of Death Gene Genie #32 - Googling the GenieNirvana in the Right Hemisphere: A Stroke of InsightChiropractic Adjustments and Artery Dissection: Is Your Neck in Safe Hands? (Source: Highlight HEALTH) Highlight HEALTH blogs http://www.medworm.com/rss/comments.php?id=1556680 Mon, 30 Jun 2008 04:56:07 +0100 1556680 http://www.medworm.com/index.php?rid=1551850&cid=t_104841_131_f&fid=35743&url=http%3A%2F%2Fthegenesherpa.blogspot.com%2F2008%2F06%2Fhows-that-for-genomic-medicine-by-press.html Warfarin......what a horrible drug!I have seen people require trasfusions, special clotting factors, surgery. I have even seen people die at the hands of this medication. How can we tame the beast???? FOR IMMEDIATE RELEASE Contact Jonathan Freed, Chief Community OfficerHelix Health, PLLC(888) 584-8999(212) 918-9394 fax webcasts@helixhealth.org or visit our website http://www.helixhealth.org/ One in four patients who receive anticoagulant therapy (warfarin) experience bleeding events. Join Dr. Steven Murphy, Dr. Gary Marchant and a panel of medical, scientific and legal experts in a 90-minute Helix Health CliniCast(TM) on genetic testing, genomic medicine and the science of accurate warfarin dosing. Greenwich, CT, June 23, 2008 — Helix Health, the first U.S. stand-alone genomic medici... Gene Sherpas: Personalized Medicine and You blogs http://www.medworm.com/rss/comments.php?id=1551850 Fri, 27 Jun 2008 01:48:00 +0100 1551850 http://www.medworm.com/index.php?rid=1283621&cid=t_104841_131_f&fid=35743&url=http%3A%2F%2Fthegenesherpa.blogspot.com%2F2008%2F03%2Fwarfarin-in-nejm-and-westchester-wag.html In a brief clash of civilizations today, I happened to be reading the Westchester WAG in the physicians' lounge. What is the Westchester WAG? It is a swanky monthly publication put out to showcase the high and mighty in Westchester County, NY. Yes it is one of the most affluent counties in the country, yes so is Fairfield County CT oh wait....isn't that where you have offices Dr Sherpa? Yes.....I have one on Park Avenue as well so it should come as no surprise that I was reading the WAG....Well maybe it should since I am from a small town in Pennsylvania and from a humble middle class family.While flipping through the swanky weddings I stumbled across an article written by Isadore Rosenfeld a physician reporter who also practices cardiology in New York City at Cornell. It's funny that he w... Gene Sherpas: Personalized Medicine and You blogs http://www.medworm.com/rss/comments.php?id=1283621 Thu, 06 Mar 2008 20:25:00 +0100 1283621 http://www.medworm.com/index.php?rid=1226875&cid=t_104841_158_f&fid=36024&url=http%3A%2F%2Fblog.healthtalk.com%2Fcaregiver%2Fjeff%2Fa-doctor-makes-a-house-call%2F Anybody hear of a doctor making a house call any time in the last, oh, 30 years? No, I haven’t either. That’s what makes my father’s most recent experience with his urologist so unusual. I take my father to see Dr. C every four months for a checkup and to get a shot of Lupron for the prostate cancer he was diagnosed with a decade or so ago. My father has never had any symptoms of this cancer, and his PSA (prostate specific antigen) test has been “undetectable” for it for some time now, but he keeps on getting the shot. I guess Dr. C is playing it safe. Or maybe the shot is what’s keeping it asymptomatic. Anyway, we showed up at the office and Dr. C came out to the waiting room looking sheepish. He said he was sorry, but the shipment of Lupron had not arrived and he could not gi... Caregiver Notes blogs http://www.medworm.com/rss/comments.php?id=1226875 Tue, 12 Feb 2008 23:26:30 +0100 1226875 http://www.medworm.com/index.php?rid=1128882&cid=t_104841_158_f&fid=36024&url=http%3A%2F%2Fblog.healthtalk.com%2Fcaregiver%2Fjeff%2Fno-holiday-from-caregiving%2F What with the holidays and a week of vacation, I have been absent from the blogosphere for a while. The last few weeks have reminded me that you can take a holiday from blogging, but the caregiving goes on. We had some weird weather. A good old fashioned Catskill Mountain snowstorm was followed by rising temperatures and days of rain (global warming?), but not all the snow got washed away, and so we managed an “off-white” Christmas. The daughters Amanda and Molly were both home, and I brought Pops over on Christmas Eve and we made up a bed for him in the den. On Christmas morning, we all took turns opening up the presents and enthusing about what everybody got everybody. I got Pops a calendar of Nova Scotia historical photos (we both are members of a genealogical and historical society... Caregiver Notes blogs http://www.medworm.com/rss/comments.php?id=1128882 Thu, 03 Jan 2008 20:53:57 +0100 1128882 http://www.medworm.com/index.php?rid=1060164&cid=t_104841_158_f&fid=36024&url=http%3A%2F%2Fblog.healthtalk.com%2Fcaregiver%2Fjeff%2Fa-caregiver-sweats-the-medications-again%2F It looked like Pops was going to get through his course of Ciprol (ciprofloxacin) treatment for a bladder infection without throwing his blood-clotting factor out of whack this time. It looked that way. No such luck. Last week – his last week on Ciprol – Pops’ blood test results came back too high. Just like the other time he took Ciprol last spring, the antibiotic interacted with his blood thinner, Coumadin, and made his blood too thin, posing the risk of a hemorrhagic stroke. It was high enough so that Pops’ doctor’s nurse Gina called to say he should skip the Coumadin for a couple of days. So I called Pops and told him to skip the “blue tablet and the half-pink tablet” (4.5 mg) for the next two days. The next day, Thanksgiving, I went and picked up Pops for Thanksg... Caregiver Notes blogs http://www.medworm.com/rss/comments.php?id=1060164 Thu, 29 Nov 2007 21:23:05 +0100 1060164 http://www.medworm.com/index.php?rid=1057462&cid=t_104841_131_f&fid=35743&url=http%3A%2F%2Fthegenesherpa.blogspot.com%2F2007%2F11%2F4-days-too-long.html This article I find especially timely. we have always known that genotypic variation plays a role in the metabolism of certain drugs. In this case, 2D6 metabolism has an even more important in the Ashkenazi Jewish. Here they find twice as many persons af Ashkenazi heritage have ultrarapid 2D6 metabolism. This enzyme is the key player in many psychiatric medications....The Sherpa Says: I am absolutely certain that ethnicity will play a huge variable in the frequency of these ultra-rapid metabolizers of any medication. Pharmacogenomics may be meeting genealogy sooner than we think....Thanks to Sherpa Hsien for helping me with a SNP issue the other day...... (Source: Gene Sherpas: Personalized Medicine and You) Gene Sherpas: Personalized Medicine and You blogs http://www.medworm.com/rss/comments.php?id=1057462 Wed, 28 Nov 2007 15:16:00 +0100 1057462 http://www.medworm.com/index.php?rid=836491&cid=t_104841_131_f&fid=35743&url=http%3A%2F%2Fthegenesherpa.blogspot.com%2F2007%2F09%2Fpilot-studybuy-stock-in-kimball.html On Friday I was picking on what I term haters of Personalized Medicine. You know those people who just shoot down the idea because of several reasonsNegative articles get print (contrarians always get published)The doubters often have no genetic training (or combined with internal medicine) and are afraid of what they may have to do if Personalized Medicine succeeds (Which it will)Their idea of Personalized Medicine is the snazzy websites of certain whole genome analysis, DTC testing or nutrigenomic fly by the night companies. Which are BTW putting a horrible stain on the name of Personalized Medicine. Francis Collins recently said "over promising can often kill a movement" so stop it. Or at least don't over promise. Please, I beg you. Recently an article was published in the Journal of Fa... Gene Sherpas: Personalized Medicine and You blogs http://www.medworm.com/rss/comments.php?id=836491 Sat, 01 Sep 2007 23:15:00 +0100 836491 http://www.medworm.com/index.php?rid=835579&cid=t_104841_131_f&fid=35743&url=http%3A%2F%2Fthegenesherpa.blogspot.com%2F2007%2F08%2Fclinical-utility-now-all-you-doubters.html I just wanted to let everyone know again about the website for coumadin dosing according to genotype. This algorithm is available on the web at warfarindosing.orgThis algorithm is going to be published tomorrow in the journal Blood.For all you hater Internists and Clinicians who refused to learn genetics or maybe never had genetics......Welcome to the 21st Century, Read the name tag. You're in my world now Grandma! (Source: Gene Sherpas: Personalized Medicine and You) Gene Sherpas: Personalized Medicine and You blogs http://www.medworm.com/rss/comments.php?id=835579 Thu, 30 Aug 2007 16:49:00 +0100 835579 http://www.medworm.com/index.php?rid=806089&cid=t_104841_131_f&fid=35743&url=http%3A%2F%2Fthegenesherpa.blogspot.com%2F2007%2F08%2Fgood-morning-america-versus-mds.html Today on Good Morning America Dr. Tim Johnson spoke about the future of Personalized Medicine. He feels that it is here and now. Take a listen to what he says. (Source: Gene Sherpas: Personalized Medicine and You) Gene Sherpas: Personalized Medicine and You blogs http://www.medworm.com/rss/comments.php?id=806089 Fri, 17 Aug 2007 19:16:00 +0100 806089 http://www.medworm.com/index.php?rid=806090&cid=t_104841_131_f&fid=35743&url=http%3A%2F%2Fthegenesherpa.blogspot.com%2F2007%2F08%2Fwall-street-and-fda-versus-mds.html If you didn't have the chance to read the Wall Street Journal today, then you missed a whopper of an article regarding Pharmacogenomic testing and how it can truly impact outcomes with medications.The article presented several stories of Warfarin gone Awry. Trust me, I have seen more than my fair share of warfarin bleeding stories. Warfarin was a drug initially used as a rat poison. In fact it was only discovered as an anticoagulant when some depressed soldier tried to kill himself with the poison.He survived, and so did one of the leading selling medications in the world. Leaving a trail of horror stories. When dosing this medication, there is an old adage that you start low and go slow. But in today's lack of reimbursement, this medication is getting started at higher and higher dosages.... Gene Sherpas: Personalized Medicine and You blogs http://www.medworm.com/rss/comments.php?id=806090 Fri, 17 Aug 2007 02:15:00 +0100 806090 http://www.medworm.com/index.php?rid=803820&cid=t_104841_150_f&fid=35777&url=http%3A%2F%2Ffeeds.feedburner.com%2F%7Er%2FPharmalot%2F%7E3%2F144857965%2F Despite controversy, the FDA today is taking a big step toward using genetics to determine dosing of the med, which also goes by the brand name Coumadin. The agency is now saying the label for the Warfarin blood thinner will say that a lower initial warfarin dose “should be considered for patients with certain genetic variations.” (Here’s the complete labeling info). “The labeling change highlights the opportunity for healthcare providers to use genetic tests to improve their initial estimate of what is a reasonable warfarin dose for individual patients. Testing may help optimize the use of warfarin and lower the risk of bleeding complications from the drug,” the FDA says in a statement. “These labeling updates are based on an analysis of recent studies ... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=803820 Thu, 16 Aug 2007 17:47:54 +0100 803820 http://www.medworm.com/index.php?rid=745637&cid=t_104841_131_f&fid=35743&url=http%3A%2F%2Fthegenesherpa.blogspot.com%2F2007%2F07%2Frestless-legs-and-decode.html In this study the research team conducted genome-wide scans of nearly 1,000 Icelanders and 188 Americans. A new chip technology was applied along with genome wide association methods. This approach allowed Drs. Rye and Stefansson to probe more than 300,000 small regions (single nucleotides) distributed across the entire genome for differences more common to RLS sufferers as compared to population-based controls.The expedition was to find a gene linked to Restless Leg Syndrome. Sleep is often interrupted in these patients and can lead to a terrible lifestyle. There is a high prevalence of this disease in North America and Europe. Seemingly a Caucasian disease it was natural to look for this linkage in the Icelanders.Here's what my Head Genomic Counselor had to say:"They found an intronic SN... Gene Sherpas: Personalized Medicine and You blogs http://www.medworm.com/rss/comments.php?id=745637 Thu, 19 Jul 2007 15:18:00 +0100 745637 http://www.medworm.com/index.php?rid=708896&cid=t_104841_131_f&fid=35743&url=http%3A%2F%2Fthegenesherpa.blogspot.com%2F2007%2F07%2Fbritain-needs-sherpa.html I just received an email from a reader who pointed my attention towards a popular morning program in the UK. They interviewed a person who had taken a genetic risk test despite the significant cost (I am uncertain of the test). The costs online are up to 1000 pounds, almost 2000 USD! She did this simply because she was concerned about pancreatic cancer (her father had died of it as age 69). She announced that she was free of the risk of pancreatic cancer but had learned that she shouldn't take HRT and had stopped it. She had also learned that she was at risk for age-related Alzhemers' (although the discussion wasn't at all clear". The discussion ended with the enthusiasm for the testing from doctor who is associated with the TV show and a call from the lay-woman that such comprehensive scr... Gene Sherpas: Personalized Medicine and You blogs http://www.medworm.com/rss/comments.php?id=708896 Mon, 02 Jul 2007 14:45:00 +0100 708896 http://www.medworm.com/index.php?rid=707216&cid=t_104841_131_f&fid=35743&url=http%3A%2F%2Fthegenesherpa.blogspot.com%2F2007%2F06%2Fwbur-posts-on-coumadin-and-personalized.html Despite the heavy Boston accent,On WBUR Carol's worries regarding Coumadin and Personalized Medicine hit home to millions of patients everywhere. This is an excellent example of the press' coverage of my specialty. Dr Sam Goldhaber a physician at Mass General talks about the promise of pharmacogenomic testing in blood thinning and avoidance of its horrible side effects. Lastly they interview the Pope of Personalized MedicineFrancis says "Is this the scenario we want personalized medicine to enter?" "The public thinks that this is snake oil (i.e. Direct to consumer testing and nutrigenomics)"In addition Dr Collins talks again about the 2 Betty's and the potential to miss diagnose and have horrific outcomes.The Sherpa Says: "Save Betty!!!" We must take the time to educate everyone about the ... Gene Sherpas: Personalized Medicine and You blogs http://www.medworm.com/rss/comments.php?id=707216 Sat, 30 Jun 2007 23:43:00 +0100 707216 http://www.medworm.com/index.php?rid=687115&cid=t_104841_131_f&fid=35743&url=http%3A%2F%2Fthegenesherpa.blogspot.com%2F2007%2F06%2Fcoumadin-and-buccal-swabs.html Prior to posting part 3 of the Brown conference I had to put Kimball Genetics on the Radar! The have devised a test to help with the scourge of Adverse Drug Reactions and Coumadin! Coumadin/Warfarin is designed to thin the blood and prevent clots causing stroke and pulmonary embolism. The test detects specific variations in the CYP2C9 and VKORC1 genes, the presence of which result in lower dose requirements for warfarin/coumadin. To help with implementation the nice people at Washington University, St Louis. The interactive website at warfarindosing.org has been developed by Brian F. Gage, MD,MSc, colleagues and is ideal for this purpose. With every test their is the Good, The Bad, and the Ugly. The Bad? Turnaround time is a day. At the American College of Cardiology conference there was a... Gene Sherpas: Personalized Medicine and You blogs http://www.medworm.com/rss/comments.php?id=687115 Wed, 06 Jun 2007 11:25:00 +0100 687115 http://www.medworm.com/index.php?rid=687121&cid=t_104841_131_f&fid=35743&url=http%3A%2F%2Fthegenesherpa.blogspot.com%2F2007%2F05%2Fcoumadin-and-cancer.html There are two things I would like to post today. There have been a lot of posts regarding the new findings in FGFR2 and risk for breast cancer. I said yesterday that the population attributable risk was less than family history. This is correct if you are talking about pre-menopausal breast cancer.I have taken some time to review the article with a fine tooth comb and here are my summary hot points.The study only analyzed post-menopausal, non first degree relative, "sporadic" breast cancer. Thus these findings may not apply to you if you have a first degree relative with breast cancer.The risk for having cancer is increased even if you are wildtype ("normal") for this FGFR2 gene. Therefore the O.R. of 1.64 should be compared with 1.20 for the wildtype Odds Ratio.The authors note that in a ... Gene Sherpas: Personalized Medicine and You blogs http://www.medworm.com/rss/comments.php?id=687121 Wed, 30 May 2007 19:48:00 +0100 687121 http://www.medworm.com/index.php?rid=486525&cid=t_104841_131_f&fid=34996&url=http%3A%2F%2Ftalk.genesanddrugs.com%2F2006%2F11%2F16%2Fpharmacogenetic-testing-for-coumadin-sensitivity%2F Getting the dose of coumadin right can be difficult.  There are several algorithms for dosing, and at many of our medical centers nurses staff dedicated anticoagulation clinics.  Now there appears to be a new tool for safe and effective coumadin prescribing, a coumadin sensitivity test that looks at variations in the genes associated associated with response to coumadin–CYP2C9 and VKORC1.  You can read all about it at Hsien Hsien Lei’s excellent Genetics and Health site. Technorati Tags: coumadin, warfarin, pharmacogenetics, genetic testing, atrial fibrillation (Source: Genes & Drugs Blog) Genes & Drugs Blog blogs http://www.medworm.com/rss/comments.php?id=486525 Thu, 16 Nov 2006 18:00:51 +0100 486525