MedWorm provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest medical blog items that have been tagged with 'dendrites'. Sat, 03 Sep 2011 02:48:41 +0100 http://www.medworm.com/index.php?rid=4098201&cid=t_104652_122_f&fid=35066&url=http%3A%2F%2Fneurodudes.com%2F2010%2F10%2F20%2Fsingle-neurons-can-distinguish-inward-temporal-sequences-from-outward%2F “activating synapses in a centrifugal sequence (outward from the soma) caused a different [lesser] [cortical pyramidal] neuronal response than activating the synapses in a centripetal (inward) sequence” summary: Alain Destexhe. Dendrites Do It in Sequences (24 September 2010) Science 329 (5999), 1611. article: Tiago Branco, Beverley A. Clark, and Michael Häusser. Dendritic Discrimination of Temporal Input Sequences in Cortical Neurons (24 September 2010) Science 329 (5999), 1671. (Source: neurodudes) neurodudes blogs http://www.medworm.com/rss/comments.php?id=4098201 Thu, 21 Oct 2010 00:07:54 +0100 4098201 http://www.medworm.com/index.php?rid=3566704&cid=t_104652_122_f&fid=35066&url=http%3A%2F%2Fneurodudes.com%2F2010%2F05%2F14%2Fdendritic-organization-of-sensory-input-to-cortical-neurons-in-vivo%2F Jia, H., Rochefort, N., Chen, X., & Konnerth, A. (2010). Dendritic organization of sensory input to cortical neurons in vivo Nature, 464 (7293), 1307-1312 DOI: 10.1038/nature08947 Consider a a cortical neuron in V1, layer 2/3, whose output shows sharp orientation tuning. What is the orientation tuning of the most important inputs to that neuron? What is the spatial distribution of these inputs in the neuron’s dendritic tree? Here’s three possibilities. (1) You might expect the neuron to collect inputs which are broadly tuned for that same orientation (the “weak-bias model”). (2) Or, you might expect that the neuron as a whole collects inputs with various tunings, but that each dendritic branches would tend to collect inputs with a certain orientation. (3) Or, ... neurodudes blogs http://www.medworm.com/rss/comments.php?id=3566704 Sat, 15 May 2010 02:21:09 +0100 3566704 http://www.medworm.com/index.php?rid=2920353&cid=t_104652_122_f&fid=35066&url=http%3A%2F%2Fwww.almaden.ibm.com%2Finstitute%2Fresources%2F2006%2FDisk2.avi We had read that Dr. Henry Markram of the Blue Brain project had given a talk at TED (technology, entertainment, design), but the video wasn’t released until this month.  This talk is geared towards a general audience, rather than getting into the specific details of the Blue Brain project, as he has before.  It is engaging and includes many suggestions towards the future of neuroscience and AI. Watch it online at the TED website. (Source: neurodudes) neurodudes blogs http://www.medworm.com/rss/comments.php?id=2920353 Thu, 22 Oct 2009 17:20:25 +0100 2920353 http://www.medworm.com/index.php?rid=2553139&cid=t_104652_122_f&fid=35066&url=http%3A%2F%2Fneurodudes.com%2F2009%2F06%2F28%2Fvisualizing-synaptic-tagging-and-capture%2F A set of two articles recently came out in Science that directly visualize two different (and likely complementary) approaches to synapse specific delivery of gene products. Plasticity at specific synapses (input specificity — we’re restricting the discussion to the dendrites of the post-synaptic neuron) requires proteins (eg. new AMPA receptors) to get to those post-synaptic compartments and membranes. But the intructions for these new proteins are contained in the nucleus with the rest of the genome. Clearly, new proteins synthesized in the soma can’t just be sent everywhere, since only specific inputs (eg. particular dendritic spines) need these new proteins. How does this happen? Hence, the postulated synaptic tag. Two approaches Broadly, there are two approaches to s... neurodudes blogs http://www.medworm.com/rss/comments.php?id=2553139 Sun, 28 Jun 2009 20:47:20 +0100 2553139 http://www.medworm.com/index.php?rid=2149626&cid=t_104652_122_f&fid=35066&url=http%3A%2F%2Fneurodudes.com%2F2009%2F01%2F31%2Fscracm-chr2-circuit-mapping%2F As has become a hallmark of the Svoboda lab, this new paper in Nature (advance online publication) combines several cutting edge technologies (rAAV-delivered ChR2, most prominently, and 2-photon stimulation) to do some interesting synaptic physiology. The subcellular organization of neocortical excitatory connections : Article : Nature. They used ChR2 (with TTX and 4-AP to block action potentials) to find where on the dendritic tree particular inputs synapsed onto L3 and L5 cells and to measure the strength of those inputs. ChR2 depolarizes the input axon locally (60um spot diameter) at points of (potential) axodendritic contact. If you’ve heard the term “potential synapse” before, then think of this technique as a way of checking potential synapses and seeing if there re... neurodudes blogs http://www.medworm.com/rss/comments.php?id=2149626 Sun, 01 Feb 2009 02:40:17 +0100 2149626 http://www.medworm.com/index.php?rid=1693920&cid=t_104652_109_f&fid=35677&url=http%3A%2F%2Ffeeds.feedburner.com%2F%7Er%2FBrainBasedBusiness%2F%7E3%2F360385699%2Fleaders_age_and_the_human_brai.html If I tossed out the words leader, age and the human brain what one observation would you shoot back first?If you zoned in on the word leader and considered current complaints in many companies … you might add: - arrogant - rigid- authoritarian Zero in on popular myths about the word age I and you’d possibly suggest:- over the hill- boring- weakFocus on hearsay about the word brain and you might offer back: - fixed IQ- loss with age- test resultsHopefully rich revolutionary discoveries about the brain’s potential offer finer realities to your firm than myths stated above which limit performance far more than most people realize. How so? In a brain based workplace … the terms leader, age, and human brain conjure up amazingly potent images – with rejuvenated va... BrainBasedBusiness blogs http://www.medworm.com/rss/comments.php?id=1693920 Sat, 09 Aug 2008 16:21:22 +0100 1693920 http://www.medworm.com/index.php?rid=1536769&cid=t_104652_109_f&fid=35677&url=http%3A%2F%2Ffeeds.feedburner.com%2F%7Er%2FBrainBasedBusiness%2F%7E3%2F317577902%2Fjeffersons_unstoppable_mind_an.html Did Thomas Jefferson describe you when he said … “Nothing can stop (humans) with the right mental attitude from achieving their goals?”Or did Jefferson sketch your brain in his words … “nothing on earth can help (humans) with the wrong mental attitude…?”Either way, you’re left with a challenge… Why do some fall so far short of an organization’s vision? Or more importantly, what do high-performance brains look like? Here’s the skinny on neuroscience discoveries about unstoppable minds: 1. They see into the future while targeting the moment.2. They spark curiosity yet cultivate steady alertness.3. They capitalize on differences yet build on similarities.4. They grow dendrites and beat the pathology of aging brains.5. They ... BrainBasedBusiness blogs http://www.medworm.com/rss/comments.php?id=1536769 Sun, 22 Jun 2008 19:39:36 +0100 1536769 http://www.medworm.com/index.php?rid=1282233&cid=t_104652_122_f&fid=35066&url=http%3A%2F%2Fneurodudes.com%2F2008%2F03%2F05%2Fsplit-gfp-reconstituted-as-a-dynamic-synapse-label%2F This new technique from Cori Bargmann’s lab is one of the neatest that I’ve seen in a while. The authors split GFP into two pieces, expressing one piece presynaptically and the other postsynaptically. This creating fluorescing GFP only at sites of synaptic contact where the protein can reconstitute. They call the technique GFP Reconstitution Across Synaptic Partners (GRASP). Check out an example labeling here: The neurons are expressing mCherry in the cytoplasm but GFP is expressed only at the site of synaptic contacts where the split GFP peptides can be reconstituted into a complete GFP fluorophore. (Source: neurodudes) neurodudes blogs http://www.medworm.com/rss/comments.php?id=1282233 Thu, 06 Mar 2008 02:16:17 +0100 1282233 http://www.medworm.com/index.php?rid=1234788&cid=t_104652_109_f&fid=35677&url=http%3A%2F%2Ffeeds.feedburner.com%2F%7Er%2FBrainBasedBusiness%2F%7E3%2F235556406%2Fbrainy_people_a_to_z.html Learning institutes are endlessly reframing what brainy really means. Who’s smart and who’s not where you work? Some say that IQ makes or breaks genius possibilities …  and is likely fixed at birth. Others stress mental development comes from an ability to learn daily … through observing people ... as well as by setting personal goals for achievement. What do you say?Growing numbers of researchers agree that to be mentally astute ... is to demonstrate a wide variety of intellectual qualities. How many of the A to Z proficiencies below … for instance … describe your brain’s capability?A. – Aware - Brainy people are aware of others, of limitations and of opportunities.B. - Becoming – Brainy people constantly become more of who th... BrainBasedBusiness blogs http://www.medworm.com/rss/comments.php?id=1234788 Fri, 15 Feb 2008 13:21:44 +0100 1234788 http://www.medworm.com/index.php?rid=1093186&cid=t_104652_109_f&fid=35677&url=http%3A%2F%2Ffeeds.feedburner.com%2F%7Er%2FBrainBasedBusiness%2F%7E3%2F199923929%2Fhow_you_communicate_is_who_you.html Does this mean that on that day when you snap at a co-worker … that you become a cranky snapper? Or does it mean that you’d become a caring communicator simply stepping back to communicate carefully if another person diminishes you or devalues your offering. Surprising as this sounds, brain research now affirms that how you communicate today … literally shapes who you become tomorrow.Here are 5 ways people erode who they’d like others to see in them – all through communication blunders:  1. Communicate opinionated ideas without much regard for other’s input or new facts … and your brain’s basal ganglia reboots for more narrow opinions on that topic. 2. Lie that  all is well when you really disagree with an issue, and your brain r... BrainBasedBusiness blogs http://www.medworm.com/rss/comments.php?id=1093186 Thu, 13 Dec 2007 20:37:48 +0100 1093186 http://www.medworm.com/index.php?rid=1082054&cid=t_104652_117_f&fid=34612&url=http%3A%2F%2Fwww.thedoctorweighsin.com%2Fjournal%2F2007%2F12%2F9%2Flosing-your-mind-its-your-white-matter-stupid.html By Dov Michaeli MD, Ph.DWho hasn’t complained about loss of memory? With increasing frequency, I forget where I left my glasses, what’s her name? Where did I meet him? And for the hundredth time, what’s the name of this bird?No, it is not incipient Alzheimer’s. I still write blogs, although that’s no proof of a sound mind. I manage a large drug development project, read the newspapers daily and am up on the latest political twist. So what’s going on?Beware received wisdomWhen I went to medical school (UCSF) I was struck by a paper I read claiming that 50% of what we were taught would be either obsolete, or plain wrong, within 5 years; amazing, but true, and not very reassuring to both physician and patient. One of the things I was taught with great certi... The Doctor Weighs In blogs http://www.medworm.com/rss/comments.php?id=1082054 Sun, 09 Dec 2007 01:48:21 +0100 1082054 http://www.medworm.com/index.php?rid=1033084&cid=t_104652_109_f&fid=35677&url=http%3A%2F%2Ffeeds.feedburner.com%2F%7Er%2FBrainBasedBusiness%2F%7E3%2F186052030%2Freshape_your_brain_while_you_s.html You may not be aware of important work your brain completes while you sleep. For instance … new research shows how people process recent experiences into long-term memories. How does it work? While you snooze … the brain replays your day's events … much faster than you actually experienced them.It’s how the brain organizes long-term recall  … according to Matthew Wilson … a neurobiologist at Massachusetts Institute of Technology in Cambridge. Why play back events during sleep? This process ... allows your brain to transfer memories from short-term storage ... into longer-term storage areas. The magical shifts take place during deeper sleep cycles … and may even be linked to dreaming, we are told. What are business implications?1. Sle... BrainBasedBusiness blogs http://www.medworm.com/rss/comments.php?id=1033084 Sat, 17 Nov 2007 00:28:11 +0100 1033084 http://www.medworm.com/index.php?rid=486198&cid=t_104652_122_f&fid=35066&url=http%3A%2F%2Fneurodudes.com%2F2007%2F02%2F19%2Fpostdoctoral-positions-at-janelia-farm%2F Postdoctoral/research scientist positions are available in the inter-disciplinary group of Dmitri Chklovskii at the new Janelia Farm Research Campus of the Howard Hughes Medical Institute located in the suburbs of Washington, D.C. Candidates are expected to have a PhD in neuroscience, physics, computer science or electrical engineering. Most of the work is theoretical or computational and is done in collaboration with several experimental laboratories. Successful applicants will work on projects centered on neuronal circuits such as high-throughput reconstruction of wiring diagrams as well as combining structural and physiological data to infer circuit function. Salary will be commensurate with qualifications. For more information about research directions in the group please see: http://w... neurodudes blogs http://www.medworm.com/rss/comments.php?id=486198 Mon, 19 Feb 2007 11:27:51 +0100 486198