MedWorm provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest medical blog items that have been tagged with 'dpp-4'. Wed, 21 Jul 2010 11:21:41 +0100 http://www.medworm.com/index.php?rid=2021593&cid=t_381019_134_f&fid=35137&url=http%3A%2F%2Fdiabetesupdate.blogspot.com%2F2008%2F12%2Fmore-research-shows-januvia-and.html I spent some time this week scanning IHOP for the latest academic research about the impact of DPP-4 inhibition. This IHOP has nothing to do with pancakes. It's a database that links to all research references related to specific genes.Two new studies grabbed my attention and should be of great interest to anyone taking Januvia. These studies looked at the impact of inhibiting DPP-4 on the growth of two different kinds of cancers. This is important because the way Januvia lowers blood sugar is by inhibiting DPP-4. It does this because DPP-4 is a protease (an enzyme that chops up protein chains) that, among other things, destroys a hormone, GLP-1, that helps control blood sugar levels. When you inhibit DPP-4, GLP-1 levels to rise and blood sugars drop. But none of the drug industry-sponsore... Diabetes Update blogs http://www.medworm.com/rss/comments.php?id=2021593 Mon, 08 Dec 2008 13:24:00 +0100 2021593 http://www.medworm.com/index.php?rid=1779682&cid=t_381019_150_f&fid=35777&url=http%3A%2F%2Ffeeds.feedburner.com%2F%7Er%2FPharmalot%2F%7E3%2F386599231%2F Welcome to the working week. We hope your weekend was restful. Now, of course, the routine is settling in again as meetings and deadlines loom. So as you prepare, take a peek at a few items to help you get started. May your day go well… FDA Panel To Review Pfizer Osteoporosis Drug (The Wall Street Journal) Congress Likely To Delay Health Care Overhaul (Associated Press) Painkillers May Complicate Prostate Screening (Yahoo/Reuters) Bristol, AstraZeneca Diabetes Pill Results Reported (Yahoo/Reuters) (Source: Pharmalot) Pharmalot blogs http://www.medworm.com/rss/comments.php?id=1779682 Mon, 08 Sep 2008 11:28:28 +0100 1779682 http://www.medworm.com/index.php?rid=744863&cid=t_381019_134_f&fid=35137&url=http%3A%2F%2Fdiabetesupdate.blogspot.com%2F2007%2F07%2Fhow-januvia-works.html This blog has been getting heavy traffic from people searching for information about Januvia, and I'm also getting a lot of mail on the topic. Much of it shows that doctors do not understand the way that this new incretin drug works to lower blood sugar and are therefore prescribing it inappropriately. As a result, a lot of people who are taking Januvia report seeing very high blood sugars. Let's look at why this might be and what it tells them about their true medication needs. The main way that Januvia lowers blood sugar is by raising the level of a substance, GLP-1, which is produced in the gut and has the ability to do several things. 1. GLP-1 stimulates the beta cell to secrete insulin in a manner very similar to that of the sulfonylurea drugs like Amaryl and Glipizide (sulfs). What i... Diabetes Update blogs http://www.medworm.com/rss/comments.php?id=744863 Thu, 19 Jul 2007 14:14:00 +0100 744863 http://www.medworm.com/index.php?rid=486673&cid=t_381019_105_f&fid=35048&url=http%3A%2F%2Ffeeds.feedburner.com%2F%7Er%2FMedicineAndMan%2F%7E3%2F38547928%2F A new class of drugs are being developed to fight diabetes. The first drug Januvia (Sitagliptin phosphate) from Merck was recently approved by the FDA. Januvia enhances a natural body system called the incretin system, which helps to regulate glucose by affecting the beta cells and alpha cells in the pancreas. Through DPP-4 inhibition, Januvia works only when blood sugar is elevated to address diminished insulin due to beta-cell dysfunction and uncontrolled production of glucose by the liver due to alpha-cell and beta-cell dysfunction. The advantage of these new class of medications is that they act only when there is increased levels of blood sugar in the blood (E.g after meals). They are dosed at 100 mg/day and the cost is $4.86 per tablet. The other drug in the same class is being devel... Medicine and Man blogs http://www.medworm.com/rss/comments.php?id=486673 Wed, 18 Oct 2006 17:54:32 +0100 486673