MedWorm provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest medical blog items that have been tagged with 'drug resistance'. Sat, 03 Sep 2011 02:32:31 +0100 http://www.medworm.com/index.php?rid=4829221&cid=t_190380_136_f&fid=37846&url=http%3A%2F%2Fhealthinfoispower.wordpress.com%2F2011%2F05%2F16%2Fblunting-the-activity-of-protein-abcc10-may-help-counter-taxane-drug-resistance-in-ovarian-cancer%2F New findings by Fox Chase Cancer Center researchers identify one protein, Abcc10, as being intimately involved in resistance to certain drugs used to treat breast, ovarian, lung, and other cancers. The results suggest that blunting the activity of Abcc10 might help counter resistance and extend the effectiveness of these anticancer drugs. Today’s anticancer drugs often [...] (Source: Libby's H*O*P*E*) Libby's H*O*P*E* blogs http://www.medworm.com/rss/comments.php?id=4829221 Tue, 17 May 2011 04:02:49 +0100 4829221 http://www.medworm.com/index.php?rid=4747614&cid=t_190380_87_f&fid=39187&url=http%3A%2F%2Fgetbetterhealth.com%2Fdrug-resistant-bacteria-found-in-half-of-us-meat-and-chicken%2F2011.04.25 Drug-resistant strains of Staphylococcus aureus were found in nearly half of meat and poultry samples, and were likely from the animal themselves, a study reported. Researchers collected and analyzed 136 samples of 80 brands of beef, chicken, pork and turkey from 26 retail grocery stores in Los Angeles, Chicago, Washington, D.C., Fort Lauderdale, Fla., and Flagstaff, Ariz. Among the samples, 47% were contaminated with S. aureus, and 52% of the strains were resistant to at least three classes of antibiotics–and some to nine antibiotics. Translational Genomics Research Institute, a non-profit research organization, conducted the study and published results in Clinical Infectious Diseases. DNA testing suggested that the food animals themselves were the major source of contamination. (mo... Better Health blogs http://www.medworm.com/rss/comments.php?id=4747614 Mon, 25 Apr 2011 11:00:00 +0100 4747614 http://www.medworm.com/index.php?rid=4670111&cid=t_190380_87_f&fid=39187&url=http%3A%2F%2Fgetbetterhealth.com%2Fantibiotics-losing-the-battle-against-drug-resistant-bacteria%2F2011.04.02 The single most important medicine ever discovered is the antibiotic.  Prior to 1930, humans died at early ages of simple infections and even childbirth was a major killer of women because of infection.   The mortality rate from simple staph aureus was as high as 80%,  but between 1944 and 1972 the human life expectancy jumped by 8 years because of antibiotics.   By 1950 the golden age of antibiotics was already looking tarnished as organisms became resistant to the drugs.  Now many medical advances that we take for granted, including cancer treatment, surgery, transplantation and neonatal care are endangered by increasing antibiotic resistance and a decline in new medications to combat the super germs. Drug resistance is both a public health and global security threat. Resistance ha... Better Health blogs http://www.medworm.com/rss/comments.php?id=4670111 Sat, 02 Apr 2011 12:00:00 +0100 4670111 http://www.medworm.com/index.php?rid=3389159&cid=t_190380_139_f&fid=38879&url=http%3A%2F%2Fwww.virology.ws%2F0319-fib56.mp4 I joined Marc Pelletier on episode 56 of Futures in Biotech for a conversation with Stanford University School of Medicine Professor Karla Kirkegaard.  We talked about RNA viruses – where they came from, where they are going, and Dr. Kirkegaard’s unique approach to discovering antiviral drugs. Don’t miss this episode: Dr. Kirkegaard is a brilliant and eloquent virologist who makes complicated science easy to understand. Video courtesy of Team ODTV Download video (114 MB .mp4) (Source: virology blog) virology blog blogs http://www.medworm.com/rss/comments.php?id=3389159 Mon, 22 Mar 2010 15:02:42 +0100 3389159 http://www.medworm.com/index.php?rid=3016921&cid=t_190380_139_f&fid=38879&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FVirologyBlog%2F%7E3%2FuT27EUkmad4%2F The emergence of oseltamivir (Tamiflu)-resistant 2009 H1N1 influenza virus in a Canadian family illustrates the basic concept that viral loads depend on the dose of antiviral drug. Neuraminidase inhibitors like Tamiflu and Relenza are used to treat severe illness caused by the 2009 pandemic influenza A (H1N1) virus. The antiviral drugs may also be used to prevent infection in high-risk persons, a use called postexposure prophylaxis. For Tamiflu, that means taking 75 mg a day, compared with the same dose twice a day for treating a confirmed infection. Unfortunately, using sub-optimal levels of an antiviral drug is a recipe for disaster. In this case, a boy with asthma developed confirmed H1N1 influenza and was given Tamiflu twice a day. Tamiflu was also prescribed once a day for all members... virology blog blogs http://www.medworm.com/rss/comments.php?id=3016921 Tue, 17 Nov 2009 11:00:37 +0100 3016921 http://www.medworm.com/index.php?rid=3467783&cid=t_190380_99_f&fid=39134&url=http%3A%2F%2Fanepi.blogspot.com%2F2009%2F10%2Ftamiflu-in-river.html Intriguing thread on ProMED about Tamiflu contamination of rivers in Japan. Apparently, when we take Tamiflu, we pee out the active form of the drug. Our Tamiflu-pee then travels through the sewage system and eventually ends up back in the environment.This process has been found with a number of drugs. Several studies of the river which flows into the lake where my drinking water comes from have found high levels of antidepressants and birth control in the water. So we have mellow fish who don't reproduce (That's a joke of course, but the medicine is there and it gets in the fish).Drugs in the water can have an effect the wildlife and one wonders (suspects) if we end up drinking them again. In the case of Tamiflu, there is a potential for waterfowl to consume the water and breed resistance... The Epidemiologist blogs http://www.medworm.com/rss/comments.php?id=3467783 Mon, 05 Oct 2009 14:29:00 +0100 3467783 http://www.medworm.com/index.php?rid=2101007&cid=t_190380_131_f&fid=34989&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FGeneticsHealth%2F%7E3%2FoUb1MJW-Qqk%2F A gene responsible for spreading breast cancer and making tumors resistant to chemotherapy has been identified by scientists from Princeton University. The “metastasis gene” called Metadherin, or MTDH is turned on in 40% of breast cancer tumors. It is also found in 20% of prostate cancer patients studied. The gene helps spread cancer by making the tumor cells stick to blood vessels that bring them to distant areas of the body. MTDH also makes the tumors more resistant to chemotherapy drugs. Discovering this gene helps scientist “hit two birds in one stone”, says senior author Dr. Yibin Kang to Newsday. “If you come up with a therapy that inhibits the gene, it could make the tumor more susceptible to chemotherapy and at the same time reduce the chance for a t... Genetics and Health blogs http://www.medworm.com/rss/comments.php?id=2101007 Tue, 13 Jan 2009 13:29:32 +0100 2101007 http://www.medworm.com/index.php?rid=1727808&cid=t_190380_136_f&fid=37846&url=http%3A%2F%2Fhealthinfoispower.wordpress.com%2F2008%2F07%2F21%2Ftp53-gene-mutation-found-in-80-of-high-grade-ovarian-serous-carcinomas-tp53-not-directly-involved-in-the-development-of-drug-resistance%2F “… [T]he [Johns Hopkins] research team concluded that the frequency of TP53 gene mutations using purified tumor DNA from ovarian serous carcinomas was 80.3%, which is much higher than previously reported in the medical literature. Furthermore, the research team found that TP53 is not directly involved in the development of drug resistance in high-grade ovarian [...] (Source: Libby's H*O*P*E*) Libby's H*O*P*E* blogs http://www.medworm.com/rss/comments.php?id=1727808 Tue, 22 Jul 2008 05:42:32 +0100 1727808 http://www.medworm.com/index.php?rid=810000&cid=t_190380_107_f&fid=36045&url=http%3A%2F%2Fbayblab.blogspot.com%2F2007%2F08%2Fstem-cell-delusion-are-they-still-stem.html On a previous episode of the bayblab podcast, I argued (rather poorly) that so-called mammalian "stem" cells are not so magical and deterministic as we think (ie they do not "exist"). Rather, I attempted to argue, the stem cell illusion is an emergent property of fundamental cell population dynamics and is even exhibited by the lowly unicellular prokaryotes, as exemplified by the phenomenon of bacterial persistence. A new PLOSone paper explores the theoretical basis of bacterial persistence as population bet-hedging:"Within a population of bacteria there exists a subgroup of cells that do not grow at the normal rate but exists in a quiescent, non-growing or slow-growing state. These cells are sometimes called persister cells [1], because they are able to persist in the face of catastrophic... Bayblab blogs http://www.medworm.com/rss/comments.php?id=810000 Fri, 17 Aug 2007 04:52:00 +0100 810000