MedWorm provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest medical blog items that have been tagged with 'drug trial'. Sat, 03 Sep 2011 02:31:15 +0100 http://www.medworm.com/index.php?rid=4976158&cid=t_146627_136_f&fid=39212&url=http%3A%2F%2Fbahtocancer.com%2F2011%2F06%2Ftennis-again-2%2F This time last year, I wrote this post, about how tennis and birthdays are all wrapped up in memory with the drug trial that left me looking like a sunburned turnip and afraid I was going to die. (Or look like a sunburned turnip forever.) And this time last year, I wondered how I’d be feeling about it all now. Well, the short answer is.. not as good as I’d hoped. The fact that the anniversary of the Amazing Exploding Head is all tied up with tennis and my approaching birthday means that it’s impossible to miss. All of us are a little bit shaky. Alan and I were talking about it the other day, and we think the whole thing was so horrible not just because of the whole turnip/death thing, but because we were utterly unprepared for it. If we were Andy Murray, we’d have ... Bah! to cancer blogs http://www.medworm.com/rss/comments.php?id=4976158 Mon, 27 Jun 2011 07:40:33 +0100 4976158 http://www.medworm.com/index.php?rid=3816671&cid=t_146627_136_f&fid=39212&url=http%3A%2F%2Fbahtocancer.com%2F2010%2F07%2Fall-about-persephone-part-1%2F As I mentioned last week, the team running the Persephone trial have been good enough to answer some questions about Herceptin and the trial. Here they are. Even though I’m done with Herceptin, i found this really interesting. I hope you do too. * -Why is Herceptin such a wonder drug? Herceptin has proved to be a major advance as it helps to cure a certain type of aggressive breast cancer described as HER2 positive. This cancer is made of cells which contain HER2, a molecule involved in the rapid multiplication of cancer cells. - In layman’s terms, what is the Persephone trial and how did it come about? The PERSEPHONE trial is about finding the right dose of Herceptin for the patient. At the moment, Herceptin is given for a whole year based on evidence from an international t... Bah! to cancer blogs http://www.medworm.com/rss/comments.php?id=3816671 Tue, 27 Jul 2010 06:39:38 +0100 3816671 http://www.medworm.com/index.php?rid=2645353&cid=t_146627_109_f&fid=35671&url=http%3A%2F%2Fwww.anxietyinsights.info%2Fneurogenesis_stimulating_candidate_antidepressant_clears_fir.htm San Diego-based developer of neurological disorders treatments, BrainCells Inc., has announced results from the first clinical proof-of-concept study for its candidate major depressive disorder (MDD) drug BCI-952. The data were presented at NCDEU 2009, a meeting co-sponsored by the National Institute of Mental Health and the American Society of Clinical Psychopharmacology. BCI-952, is a combination of low dose buspirone (Buspar®) and melatonin, a sleep promoting hormone. Buspirone is currently approved for the treatment of generalized anxiety disorder. The BrainCells Inc. drug is designed to stimulate neurogenesis - the process by which pre-existing stem cells produce new brain cells, including neurons, in the hippocampus of the adult brain. "Our study results provide the first prospec... Latest entries from www.anxietyinsights.info blogs http://www.medworm.com/rss/comments.php?id=2645353 Tue, 28 Jul 2009 07:47:00 +0100 2645353 http://www.medworm.com/index.php?rid=2511055&cid=t_146627_109_f&fid=35671&url=http%3A%2F%2Fwww.anxietyinsights.info%2Fabstract_does_study_design_influence_outcome.htm Conclusions: Response and remission rates to antidepressants are significantly affected by study type and duration. Clinicians and researchers must consider the study design when interpreting and designing RCTs of antidepressant medications. Source...     Copyright © 2009 S. Karger AG, Basel Comment:  The finding of greater antidepressant response rates at 8 and 12 weeks compared to 6 weeks is significant. Most of the study which have found little difference between drug and placebo have been of short duration, often of less than 6 weeks. For example, only 6 of the 35 trials included in the much quoted Kirsch meta study were of 8 weeks duration, and because Kirsch et al chose to use the data "taken from the last visit prior to trial termination," the actual length of treatm... Latest entries from www.anxietyinsights.info blogs http://www.medworm.com/rss/comments.php?id=2511055 Wed, 24 Jun 2009 07:53:00 +0100 2511055 http://www.medworm.com/index.php?rid=2001027&cid=t_146627_117_f&fid=38158&url=http%3A%2F%2Famericanacupuncture.blogspot.com%2F2008%2F12%2Fprivacy-lost-in-clinical-trial.html LOSS OF PRIVACY TO RESEARCH PARTICIPATION Your privacy may not be protected if you participate in a medical reseach study. Ethically, researchers must protect your privacy and confidentiality of their data.  They get certificates of confidentiality, which are authorized by our federal government and granted by the US Dept. of Health and Human Services (HHS). Collected research information if revealed could adversely damage your finances, affect your employment and insurability, and even your reputation. The Certificates offered nearly absolute privacy protection up to now.  It protected studies in biomedical, behavioral, clinical and other research. You were protected and no Federal, state, or local civil, criminal administrative, legislative or other proceeding could identify you. Certi... Dr. Needles Medical Blogs blogs http://www.medworm.com/rss/comments.php?id=2001027 Mon, 01 Dec 2008 16:44:00 +0100 2001027 http://www.medworm.com/index.php?rid=1894936&cid=t_146627_150_f&fid=34768&url=http%3A%2F%2Fpharmagossip.blogspot.com%2F2008%2F10%2Ftgn1412-informed-consent.html Back stories here.New research presented today shows that the information given to the volunteers of the disastrous Northwick Park “Elephant Man” trial would not have passed a ‘readability’ test. The research, presented at the international meeting of the Drug Information Association today, highlights an immediate need for all information provided to volunteers in clinical trials to be ‘User Tested’ before future trial protocols can be approved.The University of Leeds commissioned Luto Research (Leeds University Testing Organisation) to undertake the User Testing component of the presented research, which highlighted that members of the public took up to an hour to find all of the answers to questions about key facts in the volunteer information provided – and with six of the... PharmaGossip blogs http://www.medworm.com/rss/comments.php?id=1894936 Wed, 22 Oct 2008 12:33:00 +0100 1894936 http://www.medworm.com/index.php?rid=1649293&cid=t_146627_109_f&fid=35671&url=http%3A%2F%2Fwww.anxietyinsights.info%2Fstudy_to_test_2_drug_approach_to_depression_treatment.htm Hoping to answer a question raised by the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study, UT Southwestern Medical Center researchers have designed the Combining Medication to Enhance Outcomes of Depression (CO-MED) trial to test multiple-medication treatment of depression. "We are trying two active, Food and Drug Administration-marketed antidepressant medicines available by prescription from your local drugstore," said Dr John Rush, professor of clinical sciences and psychiatry, CO-MED's principal investigator and head of the national study. "There have never been studies prospectively in a large representative sample to see whether the combination of these pills will be better than one." For diseases such as diabetes or hypertension, combining medicines from the sta... Latest entries from www.anxietyinsights.info blogs http://www.medworm.com/rss/comments.php?id=1649293 Wed, 23 Jul 2008 12:24:00 +0100 1649293 http://www.medworm.com/index.php?rid=1472672&cid=t_146627_109_f&fid=35671&url=http%3A%2F%2Fwww.anxietyinsights.info%2Fabstract__effectiveness_of_antidepressants_an_evidence_my.htm Philos Ethics Humanit Med. 2008;3:14doi:10.1186/1747-5341-3-14 Effectiveness of antidepressants: an evidence myth constructed from a thousand randomized trials? Ioannidis JPA. Antidepressants, in particular newer agents, are among the most widely prescribed medications worldwide with annual sales of billions of dollars. The introduction of these agents in the market has passed through seemingly strict regulatory control. Over a thousand randomized trials have been conducted with antidepressants. Statistically significant benefits have been repeatedly demonstrated and the medical literature is flooded with several hundreds of "positive" trials (both pre-approval and post-approval). However, two recent meta-analyses question this picture. The first meta-analysis used data that were submitted... Latest entries from www.anxietyinsights.info blogs http://www.medworm.com/rss/comments.php?id=1472672 Wed, 28 May 2008 08:10:00 +0100 1472672 http://www.medworm.com/index.php?rid=864631&cid=t_146627_136_f&fid=36171&url=http%3A%2F%2Ffeeds.feedburner.com%2F%7Er%2FMyeloma-cse%2F%7E3%2F154940087%2Fprofile-dr-s-v-rajkumar.html While surfing the net for new information on myeloma, it is natural to come across some names repeatedly. One such name is Dr. S V Rajkumar, MD. He is Professor of Hematology and Laboratory Medicine and Pathology at the prestigious Mayo Clinic.One of his research interests includes developing new therapies for Multiple Myeloma. It is an important area of current myeloma research. With novel regimens and novel drugs available in market there is hope for the myeloma patients.We can see Dr. Rajkumar discussing the results of a Phase III trial of combination of lenalidomide (Revlimid by Celgene) plus high dose dexamethasone versus lenalidomide plus low dose dexamethasone His team has currently initiated the Phase II multi-center 4 drug combination trial looking at efficacy of combining bortezo... Multiple Myeloma blogs http://www.medworm.com/rss/comments.php?id=864631 Tue, 11 Sep 2007 07:36:00 +0100 864631