MedWorm provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest medical blog items that have been tagged with 'fibrillation'. Sat, 03 Sep 2011 02:04:57 +0100 http://www.medworm.com/index.php?rid=5181801&cid=t_373204_87_f&fid=39187&url=http%3A%2F%2Fgetbetterhealth.com%2Fapixaban-finally-showing-superiority-over-warfarin-in-clinical-trial%2F2011.09.01 With the publication of “Apixaban versus Warfarin in Patients with Atrial Fibrillation” (the ARISTOTLE trial) in the New England Journal of Medicine, the third drug in a series of medications designed to attack thrombin in the clotting cascade. The study was announced with quite a fanfare in Europe as cardiologists, financial analysts and reporters gushed forth with ‘mega-blockbuster’ praise this past weekend. And for good reason. This is the first trial to conclude that (more…) *This blog post was originally published at Dr. Wes* (Source: Better Health) Better Health blogs http://www.medworm.com/rss/comments.php?id=5181801 Thu, 01 Sep 2011 14:00:00 +0100 5181801 http://www.medworm.com/index.php?rid=5182000&cid=t_373204_113_f&fid=39278&url=http%3A%2F%2Fblogsite.mdbuyline.com%2F%3Fp%3D342 The Zio™ Patch is an emerging FDA-approved device the size of a small calculator that can be worn under the patient’s clothes that records and stores ECG data for up to 30 days. After the ECG recordings are obtained, the device is then mailed to a national reading center to evaluate the data. There have been multiple studies that confirm the effectiveness of outpatient ECG monitoring. One study indicated that the sensitivity for diagnosing heart patients increased from 11.5% to 46.2% when they were monitored for over seven days. Another study suggested that using Holter technology to identify atrial fibrillation early could save healthcare $13,000 per year, per patient, making this technology all the more important. Dr. Carolyn M. Clancy, MD, director of the Agency for Healthcare R... MD Buyline blogs http://www.medworm.com/rss/comments.php?id=5182000 Thu, 01 Sep 2011 13:36:19 +0100 5182000 http://www.medworm.com/index.php?rid=5062245&cid=t_373204_87_f&fid=39187&url=http%3A%2F%2Fgetbetterhealth.com%2Fnew-blood-thinner-shifts-responsibility-to-patients%2F2011.07.24 I recently came across a very important blog post on the use of the novel new blood-thinner, dabigatran (Pradaxa). Fellow Kentucky cardiologist, and frequent TheHeart.org contributor, Dr. Melissa Walton-Shirley wrote this very detailed case presentation involving a cantankerous non-compliant rural patient with AF (atrial fibrillation) that sustained a stroke while “taking” dabigatran. Dr. Walton-Shirley details the very commonly done procedure of cardioversion (shock) for AF. As she clearly points out, the most important safety feature of shocking AF back to regular rhythm entails adequate blood thinning before and after the procedure. Thin blood prevents the possibility of clots dislodging after restoring normal contraction to the top chambers of the heart (atria). Herein lies the rub... Better Health blogs http://www.medworm.com/rss/comments.php?id=5062245 Sun, 24 Jul 2011 18:00:37 +0100 5062245 http://www.medworm.com/index.php?rid=5051236&cid=t_373204_150_f&fid=35777&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FPharmalot%2F%7E3%2Fb9WmMsuW1qc%2F Less than a month after Sanofi discontinued a Phase IIIb trial in patients who were treated with its Multaq heart med due to a significant increase in cardiovascular events, regulators on both sides of the pond now say they are reviewing the merits of the controversial drug. Ironically, the study found a two-fold increase in death, and two-fold increases in stroke and hospitalization for heart failure. The med is approved to reduce the risk of cardiovascular hospitalization in patients with persistent atrial fibrillation or atrial flutter who have had a recent episode and associated cardiovascular risk factors (here is the label). But the study was looking at people who suffer from permanent atrial fibrillation (see here). And so the study, called PALLAS, is now raising questions about th... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=5051236 Fri, 22 Jul 2011 12:27:27 +0100 5051236 http://www.medworm.com/index.php?rid=5050580&cid=t_373204_87_f&fid=39187&url=http%3A%2F%2Fgetbetterhealth.com%2Frecognizing-different-arrhythmias-theres-an-app-for-that%2F2011.07.21 The recognition and management of cardiac arrhythmias is a must-have clinical skill for residents and physicians, and one that is often not well-taught at some institutions. For example, deciding whether a patient is in a shockable rhythm, realizing what medications should or should not be given in a particular situation, or assessing the degree of atrioventricular block, can all be important considerations in patient care. The Arrhythmias app, designed by Abe Balsamo, recently cracked the Top 10 list of most-downloaded medical apps in the app store.  This app represents Mr. Balsamo’s first foray into the app world, though he has several other apps in development, according to his website AppsByAbe.com.  The app’s growing popularity has been driven by its point-of-care abilities that... Better Health blogs http://www.medworm.com/rss/comments.php?id=5050580 Thu, 21 Jul 2011 12:00:55 +0100 5050580 http://www.medworm.com/index.php?rid=5008663&cid=t_373204_150_f&fid=35777&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FPharmalot%2F%7E3%2FAh9019sQsPk%2F Call it a sad irony. Sanofi has discontinued a Phase IIIb trial in patients who were being treated with its Multaq heart med and suffer from permanent atrial fibrillation. Why? There was a significant increase in cardiovascular events. And so the study’s operations committee and a data monitoring committee recommended ending the trial, known as Pallas. This is only the latest setback for Sanofi and its Multaq heart med, which is supposed to bolster flagging fortunes. Last month, French regulators reevaluated the effectiveness of the drug after two patients developed severe liver damage and decided Multaq is “insufficient,” which means French authorities could withdraw reimbursement (see this). Sanofi says the decision to end the trial was not related to kidney damage (read here)... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=5008663 Thu, 07 Jul 2011 15:49:23 +0100 5008663 http://www.medworm.com/index.php?rid=4789244&cid=t_373204_87_f&fid=39187&url=http%3A%2F%2Fgetbetterhealth.com%2Fshould-competitive-cyclists-undergo-cardiac-ablation-for-atrial-fibrillation%2F2011.05.06 The number of emails that come from fellow cyclists (and endurance athletes) with heart rhythm issues amazes me. I am more convinced than ever that our “hobby” predisposes us to electrical issues like atrial fibrillation (AF)—that the science is right. Obviously, my pedaling “habit” creates an exposure bias. I hear from many of you because we cyclists understand each other. Like you, I consider not competing a lousy treatment option. As a bike racer, I know things: that prancing on an elliptical trainer at a health club doesn’t cut it, and, that spin classes may look hard, but do not come close to simulating real competition. I know the extent of the inflammation required to close that gap, to avoid getting dropped when one of the local Cancellara-types have you in the gutter i... Better Health blogs http://www.medworm.com/rss/comments.php?id=4789244 Fri, 06 May 2011 08:38:25 +0100 4789244 http://www.medworm.com/index.php?rid=4775392&cid=t_373204_87_f&fid=39187&url=http%3A%2F%2Fgetbetterhealth.com%2Fcardiologists-not-needed-a-nurse-and-a-computer-will-do%2F2011.05.02 Wait… Before reading any further, I would like to issue a warning. If your ideas about healthcare delivery are of an older ilk; if you cling white-knuckled to past dogma, please stop reading now. What follows may cause your atria to fibrillate. Last month I wrote that the best tool for treating atrial fibrillation (AF) was to give patients information—to teach them about their AF, its complications, role of lifestyle factors and the many treatment options. I didn’t say this was easy. In fact, thoroughly explaining AF takes nearly the same time it takes me to isolate the pulmonary veins–a lot longer than the 10 minutes allotted for a typical office visit. (Remember: of a 30 minute office visit, I have to review your chart, listen attentively to your story, examine you, and complete ... Better Health blogs http://www.medworm.com/rss/comments.php?id=4775392 Mon, 02 May 2011 12:00:46 +0100 4775392 http://www.medworm.com/index.php?rid=4803146&cid=t_373204_88_f&fid=38129&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Flifeinthefastlane%2FWZHV%2F%7E3%2FRL51oCgViVc%2F The LITFL Review is your regular and reliable source for the highest highlights, sneakiest sneak peaks and loudest shout-outs from the webbed world of emergency medicine and critical care (Source: Life in the Fast Lane) Life in the Fast Lane blogs http://www.medworm.com/rss/comments.php?id=4803146 Mon, 02 May 2011 05:51:07 +0100 4803146 http://www.medworm.com/index.php?rid=4758704&cid=t_373204_86_f&fid=36669&url=http%3A%2F%2Ffadelibrary.wordpress.com%2F2011%2F04%2F27%2Fjournal-of-the-american-medical-association-2011-vol-305-no-10%2F This article recommends a general framework for evaluating driver fitness relies on a functional evaluation of multiple domains (cognitive, motor, perceptual, and psychiatric) that are important for safe driving and can be applied across many disorders, including conditions that have rarely been studied with respect to driving, and in patients with multiple conditions and medications. Neurocognitive tests, driving simulation, and road tests provide complementary sources of evidence to evaluate driver safety. No single test is sufficient to determine who should drive and who should not. An NHS Athens password is required to access this article online, alternatively contact the Library for a copy of the article. Filed under: Current Awareness Tagged: Accidents, Aging, Atrial Fibrillation, Co... Fade Library blogs http://www.medworm.com/rss/comments.php?id=4758704 Wed, 27 Apr 2011 11:32:57 +0100 4758704 http://www.medworm.com/index.php?rid=4734102&cid=t_373204_87_f&fid=39187&url=http%3A%2F%2Fgetbetterhealth.com%2Fthe-hug-that-may-have-saved-a-life%2F2011.04.20 Every once in a while we physicians make an astute (or perhaps lucky) observation that becomes a turning point in a patient’s life. I’ll never forget the time that I placed a hand on an elderly woman’s belly after she said that she felt a little bit dizzy – the pulsatile abdominal mass that I discovered set in motion a cascade of events that resulted in life-saving surgery for an disecting abdominal  aortic aneurysm (AAA). It was incredibly gratifying to be involved in saving her life – and now anyone who so much as swoons in my vicinity gets a tummy rub! (Yes, Dr. Groopman I know that’s not necessarily a rational response to one lucky “exam finding.”) Last week I made a fortunate “catch” on the order of the AAA discovery from ye... Better Health blogs http://www.medworm.com/rss/comments.php?id=4734102 Wed, 20 Apr 2011 16:00:32 +0100 4734102 http://www.medworm.com/index.php?rid=4684213&cid=t_373204_87_f&fid=34765&url=http%3A%2F%2Fhcrenewal.blogspot.com%2F2011%2F04%2Fspecial-k-red-berries-mission-hostile.html "You should not have to work around something that is not in the way" - SSThis post can be considered Part 9 of my multi-part series on the mission hostile user experience presented by commercial healthcare IT.Note: Part 1 is here, part 2 is here, part 3 is here, part 4 is here, part 5 is here, part 6 is here, and part 7 is here, and part 8 is here.Special K® Red Berries is one of my favorite cereals.In this context, however, "Special K Red Berries" is a metaphor for cerebral and other hemorrhages caused by health IT getting in the way -- actually obstructing -- physicians ordering emergency medications such as vitamin K given via the fastest route, intravenously.A cerebral hemorrhage at post-mortem (obviously). Note the big Red Berry.This EHR system, Eclypsis Sunrise Clinical Manager™,... Health Care Renewal blogs http://www.medworm.com/rss/comments.php?id=4684213 Tue, 05 Apr 2011 17:36:00 +0100 4684213 http://www.medworm.com/index.php?rid=4615111&cid=t_373204_88_f&fid=38129&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Flifeinthefastlane%2FWZHV%2F%7E3%2FUPk6PtyjgnI%2F It's time for the enigmatic eleventh edition of the LITFL Review --- a weekly round up of the best and brightest in emergency medicine and critical care on the web. (Source: Life in the Fast Lane) Life in the Fast Lane blogs http://www.medworm.com/rss/comments.php?id=4615111 Mon, 21 Mar 2011 11:03:22 +0100 4615111 http://www.medworm.com/index.php?rid=4552058&cid=t_373204_87_f&fid=39187&url=http%3A%2F%2Fgetbetterhealth.com%2Fis-turbulence-good-for-the-heart%2F2011.03.05 It’s hard to believe that turbulence could be a good thing for the heart. Consider how the word turbulent is defined: “Characterized by conflict, disorder, or confusion; not controlled or calm.” Those traits don’t sound very heart-healthy. But when it comes to heart rhythm, it turns out that a turbulent response — to a premature beat — is better than a blunted one. The more turbulent the better. No, you haven’t missed anything, and turbulence isn’t another of my typos. Until [recently], heart rate turbulence was an obscure phenomenon buried in the bowels of heart rhythm journals. What Is Heart Rate Turbulence (HRT)? When you listen to the heart of a young physically-fit patient, you are struck not just by the slowness of the heartbeat, but also by the variability... Better Health blogs http://www.medworm.com/rss/comments.php?id=4552058 Sat, 05 Mar 2011 15:00:27 +0100 4552058 http://www.medworm.com/index.php?rid=4294629&cid=t_373204_87_f&fid=39187&url=http%3A%2F%2Fgetbetterhealth.com%2Fthe-business-of-anticoagulation%2F2010.12.28 This is a guest post by Dr. Juliet Mavromatis: ********** The emergence of a new generation of anticoagulants, including the direct thrombin inhibitor, dabigatran and the factor Xa inhibitor, rivaroxaban, has the potential to significantly change the business of thinning blood in the United States. For years warfarin has been the main therapeutic option for patients with health conditions such as atrial fibrillation, venous thrombosis, artificial heart valves and pulmonary embolus, which are associated with excess clotting risk that may cause adverse outcomes, including stroke and death. However, warfarin therapy is fraught with risk and liability. The drug interacts with food and many drugs and requires careful monitoring of the prothrombin time (PT) and international normalized ratio (IN... Better Health blogs http://www.medworm.com/rss/comments.php?id=4294629 Tue, 28 Dec 2010 15:00:00 +0100 4294629 http://www.medworm.com/index.php?rid=4294639&cid=t_373204_88_f&fid=38129&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Flifeinthefastlane%2FWZHV%2F%7E3%2F7uC772wbUbI%2F A teenager in atrial fibrillation... A worrying family history... A very unusual looking ECG... Can you put together the pieces of the puzzle? (Source: Life in the Fast Lane) Life in the Fast Lane blogs http://www.medworm.com/rss/comments.php?id=4294639 Tue, 28 Dec 2010 09:17:37 +0100 4294639 http://www.medworm.com/index.php?rid=4294630&cid=t_373204_87_f&fid=39187&url=http%3A%2F%2Fgetbetterhealth.com%2Ftop-cardiology-stories-of-2010-and-predictions-for-2011%2F2010.12.27 The end of the year marks a time for list-intensive posts. Recently Larry Husten from CardioExchange and CardioBrief asked for my opinion on the three most important cardiology-related news stories of 2010. Additionally, he wanted three predictions for 2011. Here goes: Top Cardiology Stories Of 2010: 1. By far, the #1 heart story of 2010 was the release of the novel blood-thinning drug dabigatran (Pradaxa) for the prevention of stroke in atrial fibrillation. Until this October, the only way to reduce stroke risk in AF was warfarin, the active ingredient in rat poison. Assuming that there aren’t any post-market surprises, Pradaxa figures to be a true blockbuster. Doctors and patients have waited a long time to say goodbye to warfarin. 2. The Dr. Mark Midei stent story: Whether D... Better Health blogs http://www.medworm.com/rss/comments.php?id=4294630 Mon, 27 Dec 2010 22:00:00 +0100 4294630 http://www.medworm.com/index.php?rid=4253137&cid=t_373204_87_f&fid=39187&url=http%3A%2F%2Fgetbetterhealth.com%2Fdecline-in-stroke-deaths-reinforces-brain-attack-prevention%2F2010.12.13 Stroke killed 2,000 fewer Americans in 2008 (the last year with complete numbers) than it did in 2007, the Centers for Disease Control and Prevention (CDC) said yesterday in its latest annual Deaths report. That dropped stroke from the third leading cause of death in the United States to the fourth. Good news? Yes and no. It’s always good news when fewer people die. The reduction suggests a payoff for efforts to prevent stroke and improve the way doctors treat it. Yet the drop from third to fourth place is due largely to an accounting change. The CDC reorganized another category, “chronic lower respiratory diseases” (mainly chronic bronchitis and emphysema), to include complications of these diseases such as pneumonia. The change substantially increased the number of deaths in this c... Better Health blogs http://www.medworm.com/rss/comments.php?id=4253137 Mon, 13 Dec 2010 13:00:25 +0100 4253137 http://www.medworm.com/index.php?rid=4203160&cid=t_373204_87_f&fid=39187&url=http%3A%2F%2Fgetbetterhealth.com%2Flots-of-thanksgiving%2F2010.11.25 A mom who took care of us kids far better than she did herself, always. A Dad whose advice grew better with years, although it was good then. Two brothers and a sister to share a driveway basketball court with, rain or shine. The infinite love of grandparents, who lived within hollering distance over an old Connecticut stone wall. A high school guidance counselor who said I wasn’t smart enough to go to medical school. A college biology professor who rolled out a cart of beers on that first Friday evening research conference. That I watched the movie “Hoosiers” and thought to look at Indiana University for residency, and while there met so many dedicated cardiology teachers. That I have so many great colleagues to work with now. Immersing oneself in a sea of committed peo... Better Health blogs http://www.medworm.com/rss/comments.php?id=4203160 Thu, 25 Nov 2010 22:00:00 +0100 4203160 http://www.medworm.com/index.php?rid=4200564&cid=t_373204_87_f&fid=39187&url=http%3A%2F%2Fgetbetterhealth.com%2Fimproving-health-for-older-adults%2F2010.11.24 New clinical trials and published research are giving us information on how to improve health in elderly patients. Here are some brief points from the Cleveland Journal of Medicine that were surprising to me: – Each year 30 percent of people age 65 or older fall and sustain serious injuries so preventing falls and fractures is important. Vitamin D prevents both falls and fractures, but mega doses of Vitamin D (50,000 mg) might cause more falls. A better dose is 1,000mg a day in people who consume a low-calcium diet.  – Exercise boosts the effect of influenza vaccine. – The benefits of dialysis in older patients is uncertain, as it does not improve  function in people over age 80. We don’t even know if it improves survival. Older patients who receive dialysis... Better Health blogs http://www.medworm.com/rss/comments.php?id=4200564 Wed, 24 Nov 2010 21:00:00 +0100 4200564 http://www.medworm.com/index.php?rid=4168207&cid=t_373204_150_f&fid=35777&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FPharmalot%2F%7E3%2FTHVm9RmTCig%2F This study really challenges that view.” One of the study researchers, Peter Kowey of the Lankenau Institute for Medical Research, told a briefing at the American Heart Association meeting taking place this week “the fact that this drug failed in this population makes it highly unlikely that you would be able to prove efficacy in other groups,” according to Reuters. Indicated for reducing high triglycerides, the implication is that, rather than quickly expand Lovaza into a full-blown heart med, Glaxo will now have to struggle to expand beyond the health-store crowd. For its part, Glaxo says it will continue to review the data in the context of other studies, but conceded in this statement that, “in this patient population, there was clearly no benefit from Lovaza.&#... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=4168207 Mon, 15 Nov 2010 21:10:42 +0100 4168207 http://www.medworm.com/index.php?rid=4159239&cid=t_373204_87_f&fid=39187&url=http%3A%2F%2Fgetbetterhealth.com%2Fis-the-young-pharmaceutical-rep-right%2F2010.11.12 I loved my old status. Perhaps, reveled in it would be a better description. I was a crotchety, generic medicine-only doctor.** Sadly, my status changed today. Dabigatran (brand name Pradaxa) was the culprit. It was a little nerve racking. I wrote the order, looked at it, thought it out again, talking to myself: “John, are you sure you don’t want to do it the old way? [pause to think] No, I am embracing the new.”  And then, I closed the chart and handed it to the nurse. “What’s that? Pradaxa?” asked the nurse. “Stop the Lovenox? You sure?” My face must have told the story. Eight days had passed since dabigatran’s approval. “That’s plenty of time to mourn warfarin’s demise,” I thought. Enough studies, enough bl... Better Health blogs http://www.medworm.com/rss/comments.php?id=4159239 Fri, 12 Nov 2010 19:00:00 +0100 4159239 http://www.medworm.com/index.php?rid=4133718&cid=t_373204_88_f&fid=38129&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Flifeinthefastlane%2FWZHV%2F%7E3%2Ft1MpNMhgMOg%2F A 61 year old male walks up to the triage desk complaining of a funny feeling in his chest. He has had similar milder episodes in the past and has been investigated by his GP with no firm diagnosis being reached. He’s moved to Resus as he’s a bit pale and sweaty. His ECG is [...] (Source: Life in the Fast Lane) Life in the Fast Lane blogs http://www.medworm.com/rss/comments.php?id=4133718 Thu, 04 Nov 2010 08:26:27 +0100 4133718 http://www.medworm.com/index.php?rid=4053292&cid=t_373204_87_f&fid=39187&url=http%3A%2F%2Fgetbetterhealth.com%2Fwhen-the-body-rights-itself%2F2010.10.09 It’s been a very busy few weeks. Medicine is like that — seldom is “business” steady. Like rainy weeks in the southeast when you think it will never be sunny again, there are weeks when you think everyone’s atria are fibrillating. So there were shocks, and burns, and wires installed. The heart rhythm was rocking, and so were we. But in all this fury two cases stand out as a reminder that in spite of, not always because of, what we doctors do, the human body can right itself — like it did before their were drugs, procedures, and surgery. (Keep this quiet, though.) Case 1: A semi-emergent consultation for atrial flutter (AF’s crazy sister) came in. “Something has to be done, Dr. M,” was the message. She was symptomatic and scared (not nec... Better Health blogs http://www.medworm.com/rss/comments.php?id=4053292 Sat, 09 Oct 2010 16:00:00 +0100 4053292 http://www.medworm.com/index.php?rid=4002882&cid=t_373204_87_f&fid=39187&url=http%3A%2F%2Fgetbetterhealth.com%2Fin-front-of-the-mirror-of-middle-age%2F2010.09.26 “It was the best of times, it was the worst of times…” An intermission, the curtain has closed on youth, but the next act awaits. Caring for hiccups of the heart, like atrial fibrillation for example, often throws me in front of the mirror, of middle age that is, and sadly the reflections show imperfections. Since I am middle aged myself, there are my own experiences. But everyday at work, on my job site, I see the effects of these same middle-age experiences on the atrium of my patients. The results are often profound. So must be the pressures. I read a passage in the wee hours of the quiet morning, in the dark, with a flickering book light. It grabbed me. It is from Elisabeth Strout’s Pulitzer Prize-winning, Olive Kitteridge. (more…) *This blog post was... Better Health blogs http://www.medworm.com/rss/comments.php?id=4002882 Sun, 26 Sep 2010 21:00:00 +0100 4002882 http://www.medworm.com/index.php?rid=3987235&cid=t_373204_150_f&fid=35777&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FPharmalot%2F%7E3%2FU68qlUuDW8M%2F Today is a big day for Boehringer Ingelheim. The FDA’s Cardiovascular and Renal Drugs Advisory Committee is reviewing its Pradaxa drug, which the German drugmaker hopes will win an endorsement for treating stroke prevention in patients with atrial fibrillation. That outcome appears highly likely, given that FDA reviewers took the unusual step of saying the med should be approved - albeit for only one of two doses sought by BI and without a superiority claim over Warfarin, the standard but difficult-to-take treatment (see the briefing documents here). But what does this mean for the competition? You may recall that several other large drugmakers are racing to get their own bloodthinners into the hands of the nation’s doctors - Bristol-Myers Squibb and Pfizer are developing apixaban,... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=3987235 Mon, 20 Sep 2010 13:09:12 +0100 3987235 http://www.medworm.com/index.php?rid=3921076&cid=t_373204_150_f&fid=35777&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FPharmalot%2F%7E3%2F94A_3qfmuDs%2F The battle to prevent blood clots is heating up this week as several drugmakers begin releasing study results for their experimental drugs. At stake, of course, is a huge market for stroke prevention that is worth billions of dollars, since the new meds are designed to supplant warfarin and aspirin, which are troublesome or simply less effective. Toward that end, Bristol-Myers Squibb and Pfizer issued results showing patients taking their apixaban blood thinner were 54 percent less likely to have a stroke or damaging clot than those taking aspirin, and did not show significant signs of bleeding. Their Averroes study, which was presented at the European Society of Cardiology conference in Stockholm, involved about 5,600 people suffering atrial fibrillation and who are unable to use warfarin... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=3921076 Tue, 31 Aug 2010 12:05:34 +0100 3921076 http://www.medworm.com/index.php?rid=3702883&cid=t_373204_83_f&fid=34856&url=http%3A%2F%2Finsidesurgery.com%2F2010%2F06%2Fvice-president-dick-cheney-hospitalized-heart-ailments%2F It has been announced that former Vice President Dick Cheney was hospitalized two days ago with atrial fibrillation and congestive heart failure. He has received intravenous medication and is expected to be released shortly. (Source: Inside Surgery) Inside Surgery blogs http://www.medworm.com/rss/comments.php?id=3702883 Mon, 28 Jun 2010 03:26:54 +0100 3702883 http://www.medworm.com/index.php?rid=3621681&cid=t_373204_87_f&fid=39187&url=http%3A%2F%2Fgetbetterhealth.com%2Fhealth-journalism-gems-you-shouldnt-miss%2F2010.06.02 A couple of health journalism gems you shouldn’t miss just because they were published over the holiday weekend: Natasha Singer of the New York Times had an important piece, “When Patients Meet Online, Are There Side Effects?,” about privacy concerns when social networking sites like CureTogether.com and PatientsLikeMe.com offer online communities for patients and collect members’ health data for research purposes. John Fauber of the Milwaukee Journal-Sentinel published another in his “Side Effects” series on conflicts of interest in healthcare. This one was about doctors vouching for the drug Multaq for treating atrial fibrillation without ever having seen all of the data. The Minneapolis Star Tribune began a “Too Much Medicine” series. Heal... Better Health blogs http://www.medworm.com/rss/comments.php?id=3621681 Wed, 02 Jun 2010 14:00:47 +0100 3621681 http://www.medworm.com/index.php?rid=3526824&cid=t_373204_111_f&fid=39123&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Fnursingcomments%2Ftdtc%2F%7E3%2FY2IUIXhIKu0%2F           Atrial fibrillation (AF) is an irregular heartbeat that may be very fast.  Your heart has 4 compartments called chambers.  The top 2 chambers are called the atria.  The bottom 2 chambers are called the ventricles.  In atrial fibrillation, the atria stop beating regularly.  Instead, they tremble (fibrillate) in a disorganized way.  This can cause an irregular, and sometimes very fast, heartbeat.  Atrial fibrillation is most common in people older than 60 years of age.  However, you can get AF at any age.  Sometimes, atrial fibrillation has no cause, but your risk goes up if you have any of the following conditions: heart disease caused by high cholesterol, a larger heart size caused by high blood pressure, damage to a heart valve, an overactive thyroid gland, lun... Nursing Comments blogs http://www.medworm.com/rss/comments.php?id=3526824 Sun, 02 May 2010 20:31:39 +0100 3526824 http://www.medworm.com/index.php?rid=3416323&cid=t_373204_150_f&fid=35777&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FPharmalot%2F%7E3%2FL5JLqz1QWAQ%2F File this under fabulous marketing. The recently launched Multaq drug for atrial fibrillation received some unusual treatment from the American College of Cardiology and the Heart Rhythm Society, which teamed to launch a new web site devoted to treating atrial fibrillation. As noted by CardioBrief, the Sanofi-Aventis logo appears in the lower right hand corner under “site sponsors” and no other companies are listed, but there is no specific mention of sponsorship, or the role of the sponsor. Here’s where it gets interesting. Last week, the site featured a “Learn From The Experts” lecture by Eric Prystowsky who showed slides on managing atrial fibrillation and made a case for off-label and off-guideline use of Multaq, CardioBrief writes. He “relies on subgroup a... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=3416323 Mon, 29 Mar 2010 13:47:50 +0100 3416323 http://www.medworm.com/index.php?rid=3366227&cid=t_373204_105_f&fid=38964&url=http%3A%2F%2Fdrwes.blogspot.com%2F2010%2F03%2Fbasics-of-atrial-fibrillation.html ... nicely reviewed by interventional cardiologist and a fellow physician blogger, Sarah Clarke, MD over at the BCS blog.-WesMusings of a cardiologist and cardiac electrophysiologist. (Source: Dr. Wes) Dr. Wes blogs http://www.medworm.com/rss/comments.php?id=3366227 Mon, 15 Mar 2010 02:02:00 +0100 3366227 http://www.medworm.com/index.php?rid=3354358&cid=t_373204_105_f&fid=38964&url=http%3A%2F%2Fdrwes.blogspot.com%2F2010%2F03%2Fon-surgical-ablation-of-atrial.html It seems okay that if a surgeon wants to cut apart the atrium and sew it back together to fix atrial fibrillation (called the surgical MAZE procedure) during open heart surgery, that's okay. But if the surgeon wants to use a device that heats the tissue non-invasively to create non-conducting lines in the atrium, that's not okay in the eyes of the law because it isn't labeled for that use specifically for use in the left atrium by the FDA, even though the FDA approved (one example) the device for medical use.You may, therefore, market the device, subject to the general controls provisions of the Act. The general controls provisions of the Act include requirements for annual registration, listing of devices, good manufacturing practice, labeling, and prohibitions against misbranding and adu... Dr. Wes blogs http://www.medworm.com/rss/comments.php?id=3354358 Thu, 11 Mar 2010 11:30:00 +0100 3354358 http://www.medworm.com/index.php?rid=3302350&cid=t_373204_105_f&fid=38964&url=http%3A%2F%2Fdrwes.blogspot.com%2F2010%2F02%2Fantiviral-boosting-boosts-arrhythmia.html The FDA issued this press release today regarding several antivirals used in combination to treat HIV that can cause pro-arrhythmia by prolonging the QT interval on the EKG:Invirase (saquinavir) and Norvir (ritonavir) are antiviral medications given together to treat HIV infection. Norvir is given at a low dose with Invirase in order to increase the level of Invirase in the body. This is a process known as "boosting."FDA's analysis of these data is ongoing. However, healthcare professionals should be aware of this potential risk for changes to the electrical activity of the heart. Invirase and Norvir should not be used in patients already taking medications known to cause QT interval prolongation such as Class IA (such as quinidine,) or Class III (such as amiodarone) antiarrhythmic drugs; ... Dr. Wes blogs http://www.medworm.com/rss/comments.php?id=3302350 Tue, 23 Feb 2010 23:37:00 +0100 3302350 http://www.medworm.com/index.php?rid=3291877&cid=t_373204_105_f&fid=38964&url=http%3A%2F%2Fdrwes.blogspot.com%2F2010%2F02%2Fusing-videos-to-help-consent-patients.html Consenting patients for complicated procedures like atrial fibrillation ablation takes considerable time to do well and our facility might do things very differently than other institutions. To assure patients heard a consistent message and to help facilitate our visits with them, we decided to create a 9-minute video to supplement our discussions during our procedural consenting process. While our video was professionally produced (and the circles around my eyes disclose the time of day this was shot), no doubt a simpler video using a hand-held HD video camera and iMovie software on a MAC could provide similar results at lower cost.In general, I think our patients have appreciated that they can view the video online at home or here in our office as often as desired. We also have burned co... Dr. Wes blogs http://www.medworm.com/rss/comments.php?id=3291877 Sun, 21 Feb 2010 16:00:00 +0100 3291877 http://www.medworm.com/index.php?rid=2930978&cid=t_373204_87_f&fid=38368&url=http%3A%2F%2Fwww.amcp.org%2Fdata%2Fjmcp%2F244-252.pdf Last term, my Program Planning for Health Behavior Change workgroup was charged with using theory to help explain a health behavior and design a targeted intervention.  With several MDs in my group, we chose improving warfarin adherence to reduce risk of stroke in elderly patients with atrial fibrillation. 2.2 million Americans suffer from AF, a condition that causes a 4 to 5 fold increased risk for stroke. What is worse is that 5% of those ages 65+ have AF.  Luckily, warfarin is an inexpensive, generic drug that, if taken consistently and with regular physician monitoring, can reduce the risk of stroke for AF patients.   However, compliance is a problem and as a result non-compliant AF patients remain at risk for stroke. My group utilized a PRECEDE/PROCEED framework to conduct a hypot... Disruptive Women in Health Care blogs http://www.medworm.com/rss/comments.php?id=2930978 Tue, 27 Oct 2009 15:02:37 +0100 2930978 http://www.medworm.com/index.php?rid=2908554&cid=t_373204_87_f&fid=34935&url=http%3A%2F%2Fmedicine.com.my%2Fwp%2F%3Fp%3D8004 Shanun sent in this video link which is meant to create awareness of Atrial Fibrillation: from the Malaysian Medical Resources Video: Atrial Fibrillation Awareness (Source: Malaysian Medical Resources) Malaysian Medical Resources blogs http://www.medworm.com/rss/comments.php?id=2908554 Sun, 18 Oct 2009 23:00:00 +0100 2908554 http://www.medworm.com/index.php?rid=2851800&cid=t_373204_105_f&fid=38964&url=http%3A%2F%2Fdrwes.blogspot.com%2F2009%2F10%2Felectricity-and-heart.html The heart is an amazing organ - incredibly strong as it beats over 31 million times a year while generating enough pressure to eject a column of blood over 5 feet high with each beat, yet incredibly fragile as it can degenerate into a quivering, disorganized lump of muscle with little more than the current from a 9-volt battery. We've all done it at one time or another: touched a 9-volt battery to our tongue. If that little tingling sensation on the tongue is strong enough, well then, there's probably enough power left in the battery to use it in a smoke detector or transistor radio.But there is probably enough energy remaining to fibrillate the heart, too. Fortunately for those lingual testers, the not enough energy passes toward the heart as the electrons flow between the closely-approxi... Dr. Wes blogs http://www.medworm.com/rss/comments.php?id=2851800 Thu, 01 Oct 2009 17:45:00 +0100 2851800 http://www.medworm.com/index.php?rid=2367386&cid=t_373204_86_f&fid=36669&url=http%3A%2F%2Ffadelibrary.wordpress.com%2F2009%2F04%2F15%2Fthoracoscopic-epicardial-radiofrequency-ablation-for-atrial-fibrillation%2F Title: Thoracoscopic epicardial radiofrequency ablation for atrial fibrillation Source: NICE The Skinny: Guidance to the NHS in England, Wales, Scotland and Northern Ireland on thoracoscopic epicardial radiofrequency ablation for atrial fibrillation.  Atrial fibrillation is a condition that affects the heart, causing an irregular pulse. It occurs when the electrical impulses controlling the heartbeat become disorganised, so that the heart beats irregularly and too fast. When this happens, the heart cannot efficiently pump blood around the body. This may cause symptoms such as palpitations, chest pain or discomfort, shortness of breath, dizziness and fainting. Atrial fibrillation increases the risk of blood clots and stroke. In thoracoscopic epicardial radiofrequency ablation, selected are... Fade Library blogs http://www.medworm.com/rss/comments.php?id=2367386 Wed, 15 Apr 2009 09:21:31 +0100 2367386 http://www.medworm.com/index.php?rid=2190515&cid=t_373204_87_f&fid=34595&url=http%3A%2F%2Fnhsblogdoc.blogspot.com%2F2009%2F02%2Fvisit-from-dave.html Barbara is 75 years old. She has lived alone since Bob, her husband, died a few years ago. She is still quietly grieving. Bob did all the household accounts. He paid the bills, and was a dab hand at D.I.Y. Barbara does it all now. Apart from the D.I.Y., which her son, Tom, has taken over. She is managing very well, thank you. Except when the central heating boiler makes that clunking noise. It worries her. It clunked when Bob was alive but he said it was nothing serious, just the pipes expanding. Barbara understands that, but she still worries. So when that nice young man in the white van, with "Plumber" written on his smart overalls,  knocked on her door and said he was in her area, and would she like her boiler checked before the onset of winter, Barbara accepted the offer. Dave was fri... NHS Blog Doctor blogs http://www.medworm.com/rss/comments.php?id=2190515 Mon, 16 Feb 2009 17:49:00 +0100 2190515 http://www.medworm.com/index.php?rid=2144706&cid=t_373204_111_f&fid=36048&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FAHeartyLife%2F%7E3%2F68dPnbcYjlQ%2F   For something that is a little smaller than an i Pod, the implantable cardioverter defibrillator carries quite a punch. The implant has small wires running to the chambers of the heart. If there is any disruption like ventricular fibrillation the implant sends off a burst of electricity to force the heart into a normal rhythm. Before the (ICD) an attack of ventricular fibrillation was often deadly. The implant works on the same premise as the heart paddles that are used in most emergency rooms or trauma centers, to shock a patient back to life. The invention of the (ICD) has given people with heart problems, a freedom that a few years ago was unheard of. A young mother in Washington State, has a new lease on life due to her implant. She said, “That she rarely notices that the (ICD... A Hearty Life blogs http://www.medworm.com/rss/comments.php?id=2144706 Thu, 29 Jan 2009 15:00:00 +0100 2144706 http://www.medworm.com/index.php?rid=2112363&cid=t_373204_111_f&fid=36048&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FAHeartyLife%2F%7E3%2Fy4WicXrSg5U%2F Atrial fibrillation is caused when your heart’s electrical system is not functioning properly. This problem is not as serious as ventricular fibrillation, this occurs when your heart stops beating. When ventricular fibrillation occurs the heart has to be shocked back to life, as you have seen on TV. Atrial fibrillation is the most common heart arrhythmia, when there is a problem with the speed in which your heart beats; it is classified as a type of arrhythmia. AF occurs when rapid, disorganized electrical signals in the heart’s two upper chambers, called the atria (AY-tree-uh), cause them to contract very fast and irregularly (this is called fibrillation). As a result, blood pools in the atria and isn’t pumped completely into the heart’s two lower chambers, called the ve... A Hearty Life blogs http://www.medworm.com/rss/comments.php?id=2112363 Fri, 16 Jan 2009 18:28:00 +0100 2112363 http://www.medworm.com/index.php?rid=2097998&cid=t_373204_111_f&fid=36048&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FAHeartyLife%2F%7E3%2FwOuytFeTUQc%2F Women with osteoporosis, that are taking or have taken Fosamax, should ask their health care provider about an alternative treatment. Patient’s that are taking or have taken Fosamax are twice as likely to develop an irregular heartbeat. The risk is higher for those that have a family history of heart failure. There is an 86% higher risk for atrial fibrillation, for patient’s that have taken Fosamax. A study at University of Washington found that 3% of the women in their study of new cases of atrial fibrillation may be due to their use of the drug Fosamax. When you have a question about any medication that is prescribed for you, don’t hesitate to ask your health care provider about side effects. Make sure that you always get a printout of the side effects of the prescriptions at you... A Hearty Life blogs http://www.medworm.com/rss/comments.php?id=2097998 Mon, 12 Jan 2009 21:32:34 +0100 2097998 http://www.medworm.com/index.php?rid=1975916&cid=t_373204_158_f&fid=36018&url=http%3A%2F%2Fcaregiversbeacon.blogspot.com%2F2008%2F11%2Fvideo-univ-of-maryland-medical-center.html (Source: The Caregiver's Beacon - Resources, Links, Ideas, News) The Caregiver's Beacon - Resources, Links, Ideas, News blogs http://www.medworm.com/rss/comments.php?id=1975916 Thu, 20 Nov 2008 03:04:00 +0100 1975916 http://www.medworm.com/index.php?rid=1975918&cid=t_373204_158_f&fid=36018&url=http%3A%2F%2Fcaregiversbeacon.blogspot.com%2F2008%2F11%2Fvideo-understanding-atrial-fibrillation.html (Source: The Caregiver's Beacon - Resources, Links, Ideas, News) The Caregiver's Beacon - Resources, Links, Ideas, News blogs http://www.medworm.com/rss/comments.php?id=1975918 Wed, 19 Nov 2008 18:57:00 +0100 1975918 http://www.medworm.com/index.php?rid=1880153&cid=t_373204_150_f&fid=35777&url=http%3A%2F%2Ffeeds.feedburner.com%2F%7Er%2FPharmalot%2F%7E3%2F420966662%2F This study shows that episodic amiodarone treatment - in contrast to our expectations - has no clinical advantage over continuous treatment because it did not lower morbidity in patients with persistent atrial fibrillation over 2 years of follow-up,” the researchers wrote (here’s the study). In August, the FDA warned about the risk of a rare type of muscle injury seen when the cholesterol drug simvastatin is combined with amiodarone (back story). The Dutch trial included 209 men and women with irregular heartbeats assigned to receive either continuous or short-term treatment of two months. The researchers put those in the short-term group back on medication for a two-month burst if their irregular heartbeats returned. When the researchers followed up at two years, they found... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=1880153 Wed, 15 Oct 2008 00:06:37 +0100 1880153 http://www.medworm.com/index.php?rid=1433872&cid=t_373204_111_f&fid=36048&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FAHeartyLife%2F%7E3%2F287203743%2F The storm brewing in over 2.2 million Americans is scary. The lightning bolts that are associated with this storm are tiny little clots that can cause a stroke. This irregular heart beat is the most common form among the US- atrial fibrillation. In fact, as many as one in every five strokes in America are related to atrial fibrillation, which is also called AF. That’s more than 150,000 strokes a year. People with AF have a stroke risk that’s up to six times higher than the risk for other people their age — and if they have other health conditions such as diabetes or heart disease, their stroke risk is even higher. Medications and treatments such as ablation are key in treating and controlling a-fib. There is many meds out there and blood thinners to chose from. There are new up and ... A Hearty Life blogs http://www.medworm.com/rss/comments.php?id=1433872 Sat, 10 May 2008 01:12:22 +0100 1433872 http://www.medworm.com/index.php?rid=1405444&cid=t_373204_111_f&fid=36048&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FAHeartyLife%2F%7E3%2F279739501%2F Women who have used Fosamax are nearly twice as likely to develop the most common kind of chronically irregular heartbeat (atrial fibrillation) than are those who have never used it, according to research from Group Health and the University of Washington. They are saying that women that have used the commonly prescribed osteoporosis medication Fosamax have an over 85% higher chance of developing atrial fibrillation then those that have never used the medication. Now, should you run upstairs and flush your Foamax? No indeed. If you have a high risk for a-fib such as a history of an irregular heart beat, high blood pressure, history of a stroke or symptoms of a “fluttering” heart or palpitations you should make an appointment to discuss matters with your doctor. Make sure the be... A Hearty Life blogs http://www.medworm.com/rss/comments.php?id=1405444 Tue, 29 Apr 2008 00:53:02 +0100 1405444 http://www.medworm.com/index.php?rid=752817&cid=t_373204_87_f&fid=34866&url=http%3A%2F%2Fwww.thecardioblog.com%2F2007%2F07%2F24%2Fone-more-way-fish-is-good-for-you%2F Filed under: Diet, PreventionFish is accumulating quite the list of health benefits (although always be cautious of mercury levels) and now we can add a reduced risk of the dangerous irregular heart rhythm disorder: atrial fibrillation. 2+ million Americans suffer from atrial fib each year, which causes symptoms like shortness of breath, fatigue, and an increased risk for blood clots and stroke. Eating broiled or baked fish (as opposed to fried) at least a few times a week is the key to seeing this benefit, and experts credit Omega-3 fatty acids for the heart-healthy effects. If fish isn't your thing you may get similar benefits from eating other foods that are high in Omega-3's such as walnuts, flaxseed, and many green leafy veggies.Read | Permalink | Email this |... The Cardio Blog blogs http://www.medworm.com/rss/comments.php?id=752817 Tue, 24 Jul 2007 04:00:00 +0100 752817 http://www.medworm.com/index.php?rid=745514&cid=t_373204_87_f&fid=34866&url=http%3A%2F%2Fwww.thecardioblog.com%2F2007%2F07%2F20%2Fprescribed-a-blood-thinner-things-you-should-know%2F Filed under: Prevention, DrugsShortly after giving birth to her first child, my sister-in-law developed a blood clot that traveled to her lung. Because she's only in her mid-30s, she was surprised to find out she'd be taking blood thinners for the rest of her life, due to a previously undiscovered genetic blood clotting disorder. Though blood thinners are commonly prescribed to those with high risk of heart attack or stroke, they're also prescribed to prevent blood clots and to those who suffer from atrial fibrillation and congestive heart failure. When you first start using blood thinners, there are a few basics you should know, including: Blood thinners may interact with other medications you are taking, so be sure to tell you doctor about all prescription and over-the-counter drugs y... The Cardio Blog blogs http://www.medworm.com/rss/comments.php?id=745514 Fri, 20 Jul 2007 04:00:00 +0100 745514 http://www.medworm.com/index.php?rid=687115&cid=t_373204_131_f&fid=35743&url=http%3A%2F%2Fthegenesherpa.blogspot.com%2F2007%2F06%2Fcoumadin-and-buccal-swabs.html Prior to posting part 3 of the Brown conference I had to put Kimball Genetics on the Radar! The have devised a test to help with the scourge of Adverse Drug Reactions and Coumadin! Coumadin/Warfarin is designed to thin the blood and prevent clots causing stroke and pulmonary embolism. The test detects specific variations in the CYP2C9 and VKORC1 genes, the presence of which result in lower dose requirements for warfarin/coumadin. To help with implementation the nice people at Washington University, St Louis. The interactive website at warfarindosing.org has been developed by Brian F. Gage, MD,MSc, colleagues and is ideal for this purpose. With every test their is the Good, The Bad, and the Ugly. The Bad? Turnaround time is a day. At the American College of Cardiology conference there was a... Gene Sherpas: Personalized Medicine and You blogs http://www.medworm.com/rss/comments.php?id=687115 Wed, 06 Jun 2007 11:25:00 +0100 687115 http://www.medworm.com/index.php?rid=628960&cid=t_373204_85_f&fid=34692&url=http%3A%2F%2Fpolitedissent.com%2Farchives%2F1656 New Excalibur #19 “The Game Begins!” Chris Claremont, writer Scot Eaton, penciler It’s been a month since she collapsed. Her heart skipped a beat, a bunch of cells packed it in and then got swept along her bloodstream up to her brain – where they formed a blockage. As a consequence, part of her brain died. Three months in, and it’s still not clear what kind of stroke TJ suffered back in Excalibur #16. Broadly speaking, there are two types of strokes: the more common ischemic stroke, where a clot blocks off the blood flow to part of the brain; and the less common hemorrhagic stroke, where there is a bleed into the brain. Initially TJ’s symptoms seemed more suggestive of a hemorrhagic stroke, and in fact that is how Sage described her stroke in Excalibur #... Polite Dissent blogs http://www.medworm.com/rss/comments.php?id=628960 Tue, 22 May 2007 22:10:46 +0100 628960 http://www.medworm.com/index.php?rid=612097&cid=t_373204_87_f&fid=34866&url=http%3A%2F%2Fwww.thecardioblog.com%2F2007%2F05%2F14%2Fheavy-drinking-is-bad-for-your-heart-in-so-many-ways%2F Filed under: Daily newsOf course drinking in large amounts is not good for your body -- it's not good for your liver, your brain, and your heart to name a few. But research is confirming previous fears that drinking is not only bad for your heart, but it's damaging in more ways than even previously thought. A recent study showed that people who drink heavily are at a much greater risk of developing atrial fibrillation, or abnormal heart rhythm. Previous studies have linked high alcohol consumption with increased risk of stroke, heart failure, and death, so this is just one more reason in a list of many not to over-indulge. Beware the summer barbecues!Read | Permalink | Email this | Linking Blogs | Comments (Source: The Cardio Blog) The Cardio Blog blogs http://www.medworm.com/rss/comments.php?id=612097 Mon, 14 May 2007 04:00:00 +0100 612097 http://www.medworm.com/index.php?rid=486525&cid=t_373204_131_f&fid=34996&url=http%3A%2F%2Ftalk.genesanddrugs.com%2F2006%2F11%2F16%2Fpharmacogenetic-testing-for-coumadin-sensitivity%2F Getting the dose of coumadin right can be difficult.  There are several algorithms for dosing, and at many of our medical centers nurses staff dedicated anticoagulation clinics.  Now there appears to be a new tool for safe and effective coumadin prescribing, a coumadin sensitivity test that looks at variations in the genes associated associated with response to coumadin–CYP2C9 and VKORC1.  You can read all about it at Hsien Hsien Lei’s excellent Genetics and Health site. Technorati Tags: coumadin, warfarin, pharmacogenetics, genetic testing, atrial fibrillation (Source: Genes & Drugs Blog) Genes & Drugs Blog blogs http://www.medworm.com/rss/comments.php?id=486525 Thu, 16 Nov 2006 18:00:51 +0100 486525