MedWorm provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest medical blog items that have been tagged with 'flaviviridae'. Sat, 03 Sep 2011 02:54:13 +0100 http://www.medworm.com/index.php?rid=2751377&cid=t_198489_77_f&fid=37259&url=http%3A%2F%2Fwww.horizonpress.com%2Fblogger%2F2009%2F09%2Fdengue-virus-replication-complex.html Replication of all positive-stranded RNA viruses investigated so far occurs in close association with virus-induced intracellular membrane structures. Dengue virus (DENV), as a member of the family Flaviviridae, also induces such extensive rearrangements of intracellular membranes, called replication complex (RC). These RCs seem to contain viral proteins, viral RNA and host cell factors. However, the biogenesis of the RC and the three-dimensional organisation is to the most part unclear.from Sven Miller, Ines Romero-Brey, and Ralf Bartenschlager in Frontiers in Dengue Virus ResearchFurther reading: Dengue VirusFull range of books on microbiology at Microbiology Books (Source: Microbiology Blog: The weblog for microbiologists.) Microbiology Blog: The weblog for microbiologists. blogs http://www.medworm.com/rss/comments.php?id=2751377 Tue, 01 Sep 2009 10:49:00 +0100 2751377 http://www.medworm.com/index.php?rid=2442311&cid=t_198489_132_f&fid=37823&url=http%3A%2F%2Fathena.bioc.uvic.ca%2Fnode%2F1034 In the World Hepatitis Day blog ahead of the formal publication of their Perspective article in PLoS Medicine, Paul Klenerman, Vicki Fleming and Ellie Barnes of the University of Oxford describe research by Christian Drosten and colleagues about a new low-cost diagnostic test for Hepatitis C for use in developing countries. The research was recently published in PLoS Medicine. (Source: VBRC Blog) VBRC Blog blogs http://www.medworm.com/rss/comments.php?id=2442311 Tue, 26 May 2009 00:07:04 +0100 2442311 http://www.medworm.com/index.php?rid=2442314&cid=t_198489_132_f&fid=37823&url=http%3A%2F%2Fathena.bioc.uvic.ca%2Fnode%2F1031 West Nile virus (WNV) is an 11 kb positive sense, single-stranded neurotropic RNA virus that has emerged globally as a significant cause of viral encephalitis. WNV is maintained in an enzootic cycle between mosquitoes and birds but can also infect and cause disease in humans, horses, and other vertebrate animals. read more (Source: VBRC Blog) VBRC Blog blogs http://www.medworm.com/rss/comments.php?id=2442314 Thu, 21 May 2009 23:34:04 +0100 2442314 http://www.medworm.com/index.php?rid=2424367&cid=t_198489_132_f&fid=37823&url=http%3A%2F%2Fathena.bioc.uvic.ca%2Fnode%2F1025 Vaccination against viruses that show a high degree of antigenic stability can be straightforward in the strategic sense.  However, RNA viruses that generate mutants at a high rate because of poor fidelity of genomic replication constitute a particular challenge for immunization.  The optimal situation would be to target some antigenic entity that is shared among a broad spectrum of variants, but is that possible?  Turner and Doherty shed light on this issue in this recent article Thinking About Broadly Cr read more (Source: VBRC Blog) VBRC Blog blogs http://www.medworm.com/rss/comments.php?id=2424367 Wed, 20 May 2009 00:18:22 +0100 2424367 http://www.medworm.com/index.php?rid=2405843&cid=t_198489_132_f&fid=37823&url=http%3A%2F%2Fathena.bioc.uvic.ca%2Fnode%2F1024 (WNV) continues to be an enigma which Bowen et al., illuminates in the recent article Persistent West Nile virus infection in the house sparrow (Passer domesticus) read more (Source: VBRC Blog) VBRC Blog blogs http://www.medworm.com/rss/comments.php?id=2405843 Fri, 15 May 2009 00:50:29 +0100 2405843 http://www.medworm.com/index.php?rid=2399056&cid=t_198489_132_f&fid=37823&url=http%3A%2F%2Fathena.bioc.uvic.ca%2Fnode%2F1022 The crystal structure of of a soluble fragment E (sE) of dengue virus type 1 (DEN-1) has been published by Modis et al., in the May edition of the Journal of Virology. Have a look Crystal structure of dengue virus type 1 envelope protein in the postfusion conformation and its implications for membrane fusion. (Source: VBRC Blog) VBRC Blog blogs http://www.medworm.com/rss/comments.php?id=2399056 Sat, 09 May 2009 07:07:36 +0100 2399056 http://www.medworm.com/index.php?rid=2399057&cid=t_198489_132_f&fid=37823&url=http%3A%2F%2Fathena.bioc.uvic.ca%2Fnode%2F1021 By using genomic data from an intensively studied major Dengue virus (DENV) outbreak that took place in Singapore during 2005 researchers at the Novartis Institute for Tropical Diseases in Singapore were able to describe the molecular epidemiology of DENV at a uniquely fine-scaled temporal and spatial resolution.  The study is described in Genomic epidemiology of a dengue virus epidemic in urban Singapore published in the May edition of Journal of Virology.  The two DENV serotypes (DENV-1 and DENV-3) differed in read more (Source: VBRC Blog) VBRC Blog blogs http://www.medworm.com/rss/comments.php?id=2399057 Sat, 09 May 2009 06:41:45 +0100 2399057 http://www.medworm.com/index.php?rid=2390177&cid=t_198489_132_f&fid=37823&url=http%3A%2F%2Fathena.bioc.uvic.ca%2Fnode%2F1017 Hepatitis C virus (HCV) has infected more than 200 million individuals globally. Cellular immunity is believed to play a central role in the control of HCV infection. To elicit an adaptive cellular immune response, HCV antigens are processed into peptides and bind human leukocyte antigen (HLA). Once the HLA are recognized they can elicit a T cell response that can either directly lead to killing of the infected cell or cytokine secretion, respectively. read more (Source: VBRC Blog) VBRC Blog blogs http://www.medworm.com/rss/comments.php?id=2390177 Thu, 07 May 2009 00:57:08 +0100 2390177 http://www.medworm.com/index.php?rid=2390178&cid=t_198489_132_f&fid=37823&url=http%3A%2F%2Fathena.bioc.uvic.ca%2Fnode%2F1016 The article New antibody prevents infection by hepatitis C virus reports that a team of scientists at the Massachusetts Biologic Laboratories (MBL) of the University of Massachusetts Medical School (UMMS) has developed a human monoclonal antibody that neutralizes the Hepatitis C virus (HCV). The new antibody effectively neutralized the Hepatitis C virus in culture, and then prevented infection by the virus in a pre-clinical animal model of the disease. read more (Source: VBRC Blog) VBRC Blog blogs http://www.medworm.com/rss/comments.php?id=2390178 Wed, 06 May 2009 06:56:04 +0100 2390178 http://www.medworm.com/index.php?rid=2390179&cid=t_198489_132_f&fid=37823&url=http%3A%2F%2Fathena.bioc.uvic.ca%2Fnode%2F1013 Chikungunya (CHIK) virus reemerged during 2005-07 as an important pathogen causing massive disease outbreaks affecting India and several countries of the Indian Ocean.  In the article Evolutionary rates and timescale comparison of Chikungunya viruses inferred from the whole genome/E1 gene with special reference to the 2005-07 outbreak in the Indian subcontinent, Arankalle et al., applied the Bayesian Markov Chain Monte Carlo (MCMC) framework to the whole CHIK genomes and partial E1 gene datasets which explicitl read more (Source: VBRC Blog) VBRC Blog blogs http://www.medworm.com/rss/comments.php?id=2390179 Tue, 05 May 2009 01:21:01 +0100 2390179 http://www.medworm.com/index.php?rid=2390180&cid=t_198489_132_f&fid=37823&url=http%3A%2F%2Fathena.bioc.uvic.ca%2Fnode%2F1012 In the article Conservation and Variability of West Nile Virus Proteins published in PLoS this April, August et al., applied a bioinformatic approach in examining a large number of West Nile Virus (WNV) sequences available from public databases. read more (Source: VBRC Blog) VBRC Blog blogs http://www.medworm.com/rss/comments.php?id=2390180 Tue, 05 May 2009 00:42:03 +0100 2390180 http://www.medworm.com/index.php?rid=2365324&cid=t_198489_132_f&fid=37823&url=http%3A%2F%2Fathena.bioc.uvic.ca%2Fnode%2F1006 Researchers from the Pasteur Institute just published a review on flavivirus entitled Pathogenesis of flavivirus infections: using and abusing the host cell.  Flaviviruses, such as the dengue virus and the West Nile virus, are emerging arthropod-borne viruses that represent an immense global health problem. Considerable progress has been made in understanding flavivirus structure and replication strategies, but only now are the complex molecular interactions between the virus and host cell starting to be unraveled. read more (Source: VBRC Blog) VBRC Blog blogs http://www.medworm.com/rss/comments.php?id=2365324 Fri, 24 Apr 2009 00:38:06 +0100 2365324 http://www.medworm.com/index.php?rid=2365325&cid=t_198489_132_f&fid=37823&url=http%3A%2F%2Fathena.bioc.uvic.ca%2Fnode%2F1005 Bartenschlager et al., in their current paper on Composition and three-dimensional architecture of the dengue virus replication and assembly sites show with the aid of an electron microscopy that Dengue virus (DENV) modifies endoplasmic reticulum (ER) membrane structure in order to promote replication and efficient encapsidation of the genome into progeny virus. This architecture of DENV replication and assembly sites could explain the coordination of distinct steps of the flavivirus replication cycle. (Source: VBRC Blog) VBRC Blog blogs http://www.medworm.com/rss/comments.php?id=2365325 Fri, 24 Apr 2009 00:27:09 +0100 2365325 http://www.medworm.com/index.php?rid=2349275&cid=t_198489_132_f&fid=37823&url=http%3A%2F%2Fathena.bioc.uvic.ca%2Fnode%2F999 This article reviews the latest findings in the field of DEN pathogenesis, vector control and vaccine development.  Efforts have been devoted to identify the host target cells that are permissive or resistant to DEN virus replication and to decipher the downstream events that would result in either disease enhancement or protection. read more (Source: VBRC Blog) VBRC Blog blogs http://www.medworm.com/rss/comments.php?id=2349275 Fri, 17 Apr 2009 03:09:01 +0100 2349275 http://www.medworm.com/index.php?rid=2349276&cid=t_198489_132_f&fid=37823&url=http%3A%2F%2Fathena.bioc.uvic.ca%2Fnode%2F998 Chronic hepatitis C is the most common blood-borne infection in the US and is four times more common than HIV. An estimated 170 million people worldwide—3% of the global population—are infected, and up to 4 million acquire the infection each year. To eliminate detectable virus from the blood, current standard of care for hepatitis C patients is a combination of PEG-IFN-α and ribavirin, a nucleoside analog with antiviral activity. read more (Source: VBRC Blog) VBRC Blog blogs http://www.medworm.com/rss/comments.php?id=2349276 Fri, 17 Apr 2009 00:30:04 +0100 2349276 http://www.medworm.com/index.php?rid=2323783&cid=t_198489_132_f&fid=37823&url=http%3A%2F%2Fathena.bioc.uvic.ca%2Fnode%2F992 An article from The Australian recently reported that Dengue fever claimed its first victim outside the sub-tropic when an Australian-based scientist fell ill while working on concentrated strains of the virus. (Source: VBRC Blog) VBRC Blog blogs http://www.medworm.com/rss/comments.php?id=2323783 Tue, 07 Apr 2009 23:19:09 +0100 2323783 http://www.medworm.com/index.php?rid=2323789&cid=t_198489_132_f&fid=37823&url=http%3A%2F%2Fathena.bioc.uvic.ca%2Fnode%2F989 Needle-free, non-invasive nature of topically administered vaccines may reduce the risk of infection from blood-borne pathogens, this route may also be more cost effective. read more (Source: VBRC Blog) VBRC Blog blogs http://www.medworm.com/rss/comments.php?id=2323789 Thu, 02 Apr 2009 05:29:07 +0100 2323789 http://www.medworm.com/index.php?rid=2296182&cid=t_198489_132_f&fid=37823&url=http%3A%2F%2Fathena.bioc.uvic.ca%2Fnode%2F979 The etiological agent of dengue fever is transmitted to the human host during blood uptake by an infective mosquito. There is currently no vaccine available against dengue fever virus (DENV) and vector control strategies fail to prevent the emergence of dengue epidemics. A better understanding of the mechanisms and the molecules involved in the key steps of DENV transmission cycle need to be explored . Mosquito's infected salivary glands and the further injection of this infectious saliva into the human is an example of one such key event in the DENV transmission cycle. read more (Source: VBRC Blog) VBRC Blog blogs http://www.medworm.com/rss/comments.php?id=2296182 Thu, 26 Mar 2009 01:29:08 +0100 2296182 http://www.medworm.com/index.php?rid=2296184&cid=t_198489_132_f&fid=37823&url=http%3A%2F%2Fathena.bioc.uvic.ca%2Fnode%2F977 Hepatitis C virus (HCV) circulates as a heterogeneous group of quasispecies. It has been addressed that siRNA can inhibit HCV replication in-vitro using HCV clone and/or replicon which have only one genotype. The current study was conducted to assess whether siRNA can inhibit different HCV genotypes with many quasispecies and to assess whether consensus siRNA have the same effect as regular siRNA. read more (Source: VBRC Blog) VBRC Blog blogs http://www.medworm.com/rss/comments.php?id=2296184 Tue, 24 Mar 2009 03:40:02 +0100 2296184 http://www.medworm.com/index.php?rid=2296185&cid=t_198489_132_f&fid=37823&url=http%3A%2F%2Fathena.bioc.uvic.ca%2Fnode%2F976 If you are on a lookout for a current review on Japanese Encephalitis look no further than January 2009 Emerging Infectious Diseases volume 15. Abstract read more (Source: VBRC Blog) VBRC Blog blogs http://www.medworm.com/rss/comments.php?id=2296185 Sat, 21 Mar 2009 06:53:07 +0100 2296185 http://www.medworm.com/index.php?rid=2296187&cid=t_198489_132_f&fid=37823&url=http%3A%2F%2Fathena.bioc.uvic.ca%2Fnode%2F974 Using hepatitis B virus (HBV) capsid-derived chimeric nanoparticles and three-dimensional nanostructures (nickel nanohair and PVDF membrane) the researchers were able to develop a highly sensitive and specific assay system for acute myocardial infarction(AMI) marker, troponin I. Although HBV capsid was used in this study as a model viral scaffold for the surface display, other viruses or virus-like particles could also be used. read more (Source: VBRC Blog) VBRC Blog blogs http://www.medworm.com/rss/comments.php?id=2296187 Thu, 19 Mar 2009 05:59:08 +0100 2296187 http://www.medworm.com/index.php?rid=2274540&cid=t_198489_132_f&fid=37823&url=http%3A%2F%2Fathena.bioc.uvic.ca%2Fnode%2F972 In the February 20th 2009 journal of Immunity Town et al. (2009) show the interplay between Toll-like receptors (TLRs) and cytokines during West Nile virus infection and define a role for TLR-mediated production of interleukin-23 in immune cell homing and pathogenesis. (Source: VBRC Blog) VBRC Blog blogs http://www.medworm.com/rss/comments.php?id=2274540 Wed, 18 Mar 2009 01:31:03 +0100 2274540 http://www.medworm.com/index.php?rid=2274541&cid=t_198489_132_f&fid=37823&url=http%3A%2F%2Fathena.bioc.uvic.ca%2Fnode%2F970 This month in JVI researchers from the Indian Institute of Science report on Virus-specific cytolytic antibodies to non structural protein 1 of Japanese encephalitis virus effect reduction of virus output from infected cells The results point to an important role for Japanese encephalitis virus (JEV) NS1-specific human immune responses in protection against JE-encephalitis and provide a strong case for inclusion of the NS1 protein in next generation JEV vaccines. (Source: VBRC Blog) VBRC Blog blogs http://www.medworm.com/rss/comments.php?id=2274541 Tue, 17 Mar 2009 06:44:03 +0100 2274541 http://www.medworm.com/index.php?rid=2274544&cid=t_198489_132_f&fid=37823&url=http%3A%2F%2Fathena.bioc.uvic.ca%2Fnode%2F967 Yellow fever virus (YFV) is a tropical disease of great importance for public health, but specific treatment is not available.  Yellow fever is transmitted in a cycle involving monkeys and mosquitoes, humans also serve as a viraemic hosts for the mosquito infection.  RNA interference (RNAi) is a process that is induced by a double stranded RNA (dsRNA) and involves the degradation of specific sequences of RNA in the cytoplasm of eukaryotic cells. read more (Source: VBRC Blog) VBRC Blog blogs http://www.medworm.com/rss/comments.php?id=2274544 Tue, 17 Mar 2009 02:52:04 +0100 2274544 http://www.medworm.com/index.php?rid=2260159&cid=t_198489_132_f&fid=37823&url=http%3A%2F%2Fathena.bioc.uvic.ca%2Fnode%2F964 An article On a mouse monoclonal antibody that neutralizes all four dengue virus serotypes published this month in the Journal of General Virology examines a mouse monoclonal antibody raised against a dengue virus envelope glycoprotein(E).  The antibody mAb 9F12 is a suitable candidate for optimization and humanization into a therapeutic antibody to treat severe infections by dengue. (Source: VBRC Blog) VBRC Blog blogs http://www.medworm.com/rss/comments.php?id=2260159 Thu, 12 Mar 2009 01:58:06 +0100 2260159 http://www.medworm.com/index.php?rid=2260160&cid=t_198489_132_f&fid=37823&url=http%3A%2F%2Fathena.bioc.uvic.ca%2Fnode%2F963 This month in The Journal of general virology Ng ML et al., published Tyrosine 78 of premembrane protein is essential for assembly of West Nile virus Their findings based on bioinformatics analysis and alanine scanning mutagenesis indicate that the amino acid triplet Valine 76, Tyrosine 78 and Glycine 79 is absolutely conserved among flavivirus prM ectodomains. Triple mutations engineered at these residues in prM ectodomain of West Nile virus (WNV) completely abrogated virus infectivity. read more (Source: VBRC Blog) VBRC Blog blogs http://www.medworm.com/rss/comments.php?id=2260160 Wed, 11 Mar 2009 06:21:06 +0100 2260160 http://www.medworm.com/index.php?rid=2260161&cid=t_198489_132_f&fid=37823&url=http%3A%2F%2Fathena.bioc.uvic.ca%2Fnode%2F957 A recent review by Jolanda M.Smit et al., in Immunobiology examines the current knowledge on the mechanisms involved in flavivirus cell entry and discuss how antibodies may influence the course of infection towards neutralization or enhancement of viral disease. (Source: VBRC Blog) VBRC Blog blogs http://www.medworm.com/rss/comments.php?id=2260161 Wed, 11 Mar 2009 05:54:02 +0100 2260161 http://www.medworm.com/index.php?rid=2260163&cid=t_198489_132_f&fid=37823&url=http%3A%2F%2Fathena.bioc.uvic.ca%2Fnode%2F955 An editorial by Peter J.Hotez published in PLoS this month looks into transforming Guantanamo from a detainee facility to a center for research on the diseases of poverty.  Latin American nations, namely Bolivia, Guyana, Haiti, Honduras, and Nicaragua, stand out for their low economic growth, low life expectancy, and high disease rates.  Tropical diseases are prevalent with millions or tens of millions of cases of hookworm and other intestinal worm infections, Chagas disease, schistosomiasis, and deng read more (Source: VBRC Blog) VBRC Blog blogs http://www.medworm.com/rss/comments.php?id=2260163 Tue, 10 Mar 2009 04:35:05 +0100 2260163 http://www.medworm.com/index.php?rid=2235792&cid=t_198489_132_f&fid=37823&url=http%3A%2F%2Fathena.bioc.uvic.ca%2Fnode%2F951 It has been estimate that, by 2030, HCV will cause higher morbidity and mortality in industrialized countries than HIV.  For the latest review on Hepatitis C virus Brian J.Thomson offers information gathered from peer reviewed publications and presentations at major academic meetings.  In this review, areas of agreement and controversy, new models of care and pathogenesis are being explored. (Source: VBRC Blog) VBRC Blog blogs http://www.medworm.com/rss/comments.php?id=2235792 Fri, 06 Mar 2009 01:49:47 +0100 2235792 http://www.medworm.com/index.php?rid=2218589&cid=t_198489_132_f&fid=37823&url=http%3A%2F%2Fathena.bioc.uvic.ca%2Fnode%2F944 Promoter is a most important regulatory region that controls and regulates gene expression at the transcription level. However, a limited number of data is available on the promoter motifs in the genus Flavivirus. The study published in Bioinformation in December 2008 by Seth PK et al., set out  to identify and analyze the putative promoter region present in Flavivirus.  The genome of Flavivirus open reading frame is flanked by the untranscribed region (UTR) in 5` and 3`. read more (Source: VBRC Blog) VBRC Blog blogs http://www.medworm.com/rss/comments.php?id=2218589 Fri, 27 Feb 2009 08:47:03 +0100 2218589 http://www.medworm.com/index.php?rid=2212674&cid=t_198489_132_f&fid=37823&url=http%3A%2F%2Fathena.bioc.uvic.ca%2Fnode%2F942 was published this February in PLoS Medicine. Detection and quantification of hepatitis C virus (HCV) RNA is integral to diagnostic and therapeutic regimens. All molecular assays target the viral 5′-noncoding region (5′-NCR), and all show genotype-dependent variation of sensitivities and viral load results. read more (Source: VBRC Blog) VBRC Blog blogs http://www.medworm.com/rss/comments.php?id=2212674 Wed, 25 Feb 2009 02:31:08 +0100 2212674 http://www.medworm.com/index.php?rid=2207468&cid=t_198489_132_f&fid=37823&url=http%3A%2F%2Fathena.bioc.uvic.ca%2Fnode%2F940 This month in the Journal of Virology researches report a novel flavivirus isolated from Uranotaenia mashonaensis a mosquito genus not previously known to harbour flaviviruses.  The novel virus, termed Nounané virus (which means “having it’s own way” in the local Oubi language) indicates a novel lineage within the Flaviviridae as only a distant relationship to other known flaviviruses was found. The Nounané virus is now within our flavivirus database. read more (Source: VBRC Blog) VBRC Blog blogs http://www.medworm.com/rss/comments.php?id=2207468 Tue, 24 Feb 2009 04:52:12 +0100 2207468 http://www.medworm.com/index.php?rid=2207467&cid=t_198489_132_f&fid=37823&url=http%3A%2F%2Fathena.bioc.uvic.ca%2Fnode%2F941 Dengue virus (DENV) is the most common arthropod-borne infection and despite its high clinical impact, little is known about the infectious cell entry pathway of the virus.  In the article Dissecting the Cell Entry Pathway of Dengue Virus by Single-Particle Tracking in Living Cells published in December 2008 the researchers used live-cell imaging and single-virus tracking to investigate the cell entry, endocytic trafficking, and fusion behavior of DENV. read more (Source: VBRC Blog) VBRC Blog blogs http://www.medworm.com/rss/comments.php?id=2207467 Tue, 24 Feb 2009 04:52:08 +0100 2207467 http://www.medworm.com/index.php?rid=2202634&cid=t_198489_132_f&fid=37823&url=http%3A%2F%2Fathena.bioc.uvic.ca%2Fnode%2F934 The incidence of dengue fever epidemics has increased dramatically over the last few decades.  Annually, 100 million cases of dengue fever (DF) and 500,000 cases of dengue hemorrhagic fever (DHF) occur, particularly in tropical Asia, Latin America, and the Caribbean.  There is no vaccine or treatment other than vector control and supportive medical care. read more (Source: VBRC Blog) VBRC Blog blogs http://www.medworm.com/rss/comments.php?id=2202634 Sat, 21 Feb 2009 04:04:08 +0100 2202634 http://www.medworm.com/index.php?rid=2202637&cid=t_198489_132_f&fid=37823&url=http%3A%2F%2Fathena.bioc.uvic.ca%2Fnode%2F931 Sanofi Pasteur announced in its press release yesterday that its investigational tetravalent dengue vaccine is entering  a pediatric clinical study in Thailand to asses the efficacy of the vaccine against dengue in children.  Sanofi Pasteur’s tetravalent dengue vaccine candidate is the first to reach this stage of clinical development.  Sanofi Pasteur is collaborating with Mahidol University of Thailand, the Ministry of Public Health, and the Pediatric Dengue Vaccine Initiativ read more (Source: VBRC Blog) VBRC Blog blogs http://www.medworm.com/rss/comments.php?id=2202637 Fri, 20 Feb 2009 08:22:06 +0100 2202637 http://www.medworm.com/index.php?rid=2178622&cid=t_198489_132_f&fid=37823&url=http%3A%2F%2Fathena.bioc.uvic.ca%2Fnode%2F921 The evolution of DENV has had a major impact on their virulence for humans and on the epidemiology of dengue disease around the world.  Increasing viral intra-genetic diversity requires an effective method for genotype identification. read more (Source: VBRC Blog) VBRC Blog blogs http://www.medworm.com/rss/comments.php?id=2178622 Thu, 12 Feb 2009 04:02:07 +0100 2178622 http://www.medworm.com/index.php?rid=2164615&cid=t_198489_132_f&fid=37823&url=http%3A%2F%2Fathena.bioc.uvic.ca%2Fnode%2F917 A recent review entitled Yellow fever vaccine: past, present and future highlights the history of yellow fever vaccine development, and focuses on practical aspects of vaccine safety, contraindications for vaccination, and future vaccine developments. Yellow fever (YF) is caused by an arbovirus  from the Flaviviridae viral family. read more (Source: VBRC Blog) VBRC Blog blogs http://www.medworm.com/rss/comments.php?id=2164615 Fri, 06 Feb 2009 04:15:08 +0100 2164615 http://www.medworm.com/index.php?rid=2142501&cid=t_198489_132_f&fid=37823&url=http%3A%2F%2Fathena.bioc.uvic.ca%2Fnode%2F904 Dengue virus (DENV), a mosquito borne flavivirus is an important pathogen causing more than 50 million infections every year around the world.  There is need for a rapid, sensitive and high throughput method for detection of DENV in the early stages of the disease.  In the article published January 2009 in Virology Journal, Cecilia et al., investigate the new generation TaqMan Minor Groove Binding (MGB) probe approach in order to develop an improved real time RT-PCR (qRT-PCR) for DENV. (Source: VBRC Blog) VBRC Blog blogs http://www.medworm.com/rss/comments.php?id=2142501 Thu, 29 Jan 2009 06:11:01 +0100 2142501 http://www.medworm.com/index.php?rid=2142502&cid=t_198489_132_f&fid=37823&url=http%3A%2F%2Fathena.bioc.uvic.ca%2Fnode%2F903 Mosquito-based surveillance consists of the systematic collection of mosquito samples and testing of mosquito pools for arboviruses in order to assess the status of transmission and allow informed decision-making.  In Fundamental issues in mosquito surveillance for arboviral transmission Novak et al.  examines arboviral transmission and the relevant methodologies that can improve effectiveness and efficiency of mosquito surveill read more (Source: VBRC Blog) VBRC Blog blogs http://www.medworm.com/rss/comments.php?id=2142502 Thu, 29 Jan 2009 05:53:07 +0100 2142502 http://www.medworm.com/index.php?rid=2142503&cid=t_198489_132_f&fid=37823&url=http%3A%2F%2Fathena.bioc.uvic.ca%2Fnode%2F900 A: Hoarding rainwater could 'dramatically' expand range of dengue-fever mosquito Ecologists developed a new model to predict the impact of climate change on the dengue fever-carrying mosquito Aedes aegypti in Australia.  Information gained from this study may help limit the spread of dengue. read more (Source: VBRC Blog) VBRC Blog blogs http://www.medworm.com/rss/comments.php?id=2142503 Thu, 29 Jan 2009 03:27:01 +0100 2142503 http://www.medworm.com/index.php?rid=2142504&cid=t_198489_132_f&fid=37823&url=http%3A%2F%2Fathena.bioc.uvic.ca%2Fnode%2F899 Small interfering RNA (siRNA) are short (20-25nt) dsRNA molecules that have several biological functions.  Most importantly they interfere with the expression of a specific gene.  It has been observed that siRNA can inhibit Hepatitis C virus (HCV) replication in vitro.  In the recent paper "Consensus siRNA for inhibition of HCV genotype-4 replication" Zekri et al. investigate whether consensus siRNA will have the same affect as regular siRNA.  Their findings indicated that consensus siRNA could infact be used in molecular target therapy against several HCV quasispeci read more (Source: VBRC Blog) VBRC Blog blogs http://www.medworm.com/rss/comments.php?id=2142504 Thu, 29 Jan 2009 03:10:01 +0100 2142504 http://www.medworm.com/index.php?rid=2142505&cid=t_198489_132_f&fid=37823&url=http%3A%2F%2Fathena.bioc.uvic.ca%2Fnode%2F898 Hepatitis C virus (HCV) is known to use a multi-receptor complex to gain entry into cells.  The two viral glycoproteins E1 and E2 are known to form a heterodimer however the interactions of the cell entry process have not been elucidated.  In the recent paper "Analysis of a conserved RGE/RGD motif in HCV E2 in mediating entry" by Rothwangl and Rong, the highly conserved RGE/RGD sequence of E2 was investigated.  To read about the findings and conclusions of this open access paper check it out at Virology Journal. read more (Source: VBRC Blog) VBRC Blog blogs http://www.medworm.com/rss/comments.php?id=2142505 Thu, 29 Jan 2009 02:13:01 +0100 2142505 http://www.medworm.com/index.php?rid=2117385&cid=t_198489_132_f&fid=37823&url=http%3A%2F%2Fathena.bioc.uvic.ca%2Fnode%2F893 Given the growing concern about West Nile virus (WNV) there is a constant push to monitor its prevalence and spread.  During the routine monitoring for WNV in the Yucatan Peninsula a novel infectious agent was identified.  This virus which has been tentitively named T'Ho virus is a flavivirus most closely related to WNV, St. Louis encephalitis virus, and Ilheus virus.  Follow this link to find out more about the discovery and preliminary discription of the T'Ho virus. (Source: VBRC Blog) VBRC Blog blogs http://www.medworm.com/rss/comments.php?id=2117385 Wed, 21 Jan 2009 08:37:02 +0100 2117385 http://www.medworm.com/index.php?rid=2117387&cid=t_198489_132_f&fid=37823&url=http%3A%2F%2Fathena.bioc.uvic.ca%2Fnode%2F891 The book Advances in Virus Research covers a diverse range of current research in the field of virology.  In the most recent (72) volume you can find a valuable overview of of the history and evolution of the Dengue virus. read more (Source: VBRC Blog) VBRC Blog blogs http://www.medworm.com/rss/comments.php?id=2117387 Tue, 20 Jan 2009 07:44:03 +0100 2117387 http://www.medworm.com/index.php?rid=2117388&cid=t_198489_132_f&fid=37823&url=http%3A%2F%2Fathena.bioc.uvic.ca%2Fnode%2F890 Dengue virus poses a large risk to human health and is the focus of many studies.  In the recently published paper "Spatial and Temporal Clustering of Dengue Virus Transmission in Thai Villages" Mammen et al. read more (Source: VBRC Blog) VBRC Blog blogs http://www.medworm.com/rss/comments.php?id=2117388 Tue, 20 Jan 2009 05:05:07 +0100 2117388 http://www.medworm.com/index.php?rid=2108640&cid=t_198489_132_f&fid=37823&url=http%3A%2F%2Fathena.bioc.uvic.ca%2Fnode%2F886 Hepatitis C virus (HCV) infection is one of the most significant health problems affecting humans. An estimated 170 million individuals (3%) worldwide and more than 4 million Americans (1.3%) are infected with HCV.  HCV is incurable in many patients and in approximately 80% of patients the virus leads to a chronic form of hepatitis. read more (Source: VBRC Blog) VBRC Blog blogs http://www.medworm.com/rss/comments.php?id=2108640 Fri, 16 Jan 2009 08:06:01 +0100 2108640 http://www.medworm.com/index.php?rid=2108641&cid=t_198489_132_f&fid=37823&url=http%3A%2F%2Fathena.bioc.uvic.ca%2Fnode%2F885 In a recent press release Anadys Pharmaceuticals announced preliminary results from ongoing clinical trials of their antiviral drug ANA598.  This new drug offers an exciting alternative to current HCV treatments as a non-nucleoside polymerase inhibitor.  With an impressive reduction of viral load (in excess of 99%) and no serious adverse effects ANA598 has potential to radically change the treatment of chronic HCV infections. read more (Source: VBRC Blog) VBRC Blog blogs http://www.medworm.com/rss/comments.php?id=2108641 Fri, 16 Jan 2009 05:13:09 +0100 2108641 http://www.medworm.com/index.php?rid=2105555&cid=t_198489_132_f&fid=37823&url=http%3A%2F%2Fathena.bioc.uvic.ca%2Fnode%2F884 In a recent review on West Nile Virus (WNV) Young P.R. et al. highlight current advances towards the development of NS2B/NS3 protease antiviral inhibitors and their implementation in antiviral therapy to combat this rapidly spreading virus. Abstract read more (Source: VBRC Blog) VBRC Blog blogs http://www.medworm.com/rss/comments.php?id=2105555 Thu, 15 Jan 2009 07:41:00 +0100 2105555 http://www.medworm.com/index.php?rid=2081826&cid=t_198489_132_f&fid=37823&url=http%3A%2F%2Fathena.bioc.uvic.ca%2Fnode%2F876 In the recently published article  Molecular profiling of T-helper immune genes during dengue virus infection  in Virology Journal (Source: VBRC Blog) VBRC Blog blogs http://www.medworm.com/rss/comments.php?id=2081826 Tue, 06 Jan 2009 08:31:04 +0100 2081826 http://www.medworm.com/index.php?rid=1997548&cid=t_198489_132_f&fid=37823&url=http%3A%2F%2Fathena.bioc.uvic.ca%2Fnode%2F845 We are all familiar with hospital-acquired infections and the risk of getting such an infection.  Post-transplant viral infections, most often caused by cytomegalovirus and Epstein-Barr virus, can lead to serious illness and even death.  In his review article "Emerging Viruses in Transplantation: There Is More to Infection After Transplant Than CMV and EBV" Fisher discusses several emerging viral pathogens in transplant patients.  He describes the symptoms, diagnoses and possible treatments for many recently described viral infections.   read more (Source: VBRC Blog) VBRC Blog blogs http://www.medworm.com/rss/comments.php?id=1997548 Fri, 28 Nov 2008 08:22:08 +0100 1997548 http://www.medworm.com/index.php?rid=1997550&cid=t_198489_132_f&fid=37823&url=http%3A%2F%2Fathena.bioc.uvic.ca%2Fnode%2F844 With increased distribution and incidence Dengue viruses have risen to global importance.  Arujo et al. study the phylogeography of three major dengue genotypes.  The aim of this study is to understand the spread and evolution of one of the most rapidly changing serotypes (DENV-3) on a global scale over the last 50 years.  They estimate that DENV-3 originated in the late 19th century, with current major genotypes emerging in the 1960's and 1970's. read more (Source: VBRC Blog) VBRC Blog blogs http://www.medworm.com/rss/comments.php?id=1997550 Thu, 27 Nov 2008 21:08:46 +0100 1997550 http://www.medworm.com/index.php?rid=1962564&cid=t_198489_132_f&fid=37823&url=http%3A%2F%2Fathena.bioc.uvic.ca%2Fnode%2F828 Antiviral Res. 2008 Nov;80(2):87-93. Epub 2008 Jul 9. Mouse models of dengue virus infection and disease. read more (Source: VBRC Blog) VBRC Blog blogs http://www.medworm.com/rss/comments.php?id=1962564 Fri, 14 Nov 2008 06:28:00 +0100 1962564 http://www.medworm.com/index.php?rid=1941012&cid=t_198489_132_f&fid=37823&url=http%3A%2F%2Fathena.bioc.uvic.ca%2Fnode%2F819 Another of Alan Cann's posts: Clustering of dengue virus infections « MicrobiologyBytes Powered by ScribeFire. (Source: VBRC Blog) VBRC Blog blogs http://www.medworm.com/rss/comments.php?id=1941012 Thu, 06 Nov 2008 00:51:00 +0100 1941012 http://www.medworm.com/index.php?rid=1918666&cid=t_198489_132_f&fid=37823&url=http%3A%2F%2Fathena.bioc.uvic.ca%2Fnode%2F816 Denison's recent article in PLoS Biology on Seeking Membranes:  Positive-Strand RNA Virus Replication Complexes explores the evolution of viral cell biology. read more (Source: VBRC Blog) VBRC Blog blogs http://www.medworm.com/rss/comments.php?id=1918666 Thu, 30 Oct 2008 03:44:03 +0100 1918666 http://www.medworm.com/index.php?rid=1887427&cid=t_198489_132_f&fid=37823&url=http%3A%2F%2Fathena.bioc.uvic.ca%2Fnode%2F808 Rev Med Virol. 2008 Sep-Oct;18(5):331-46. read more (Source: VBRC Blog) VBRC Blog blogs http://www.medworm.com/rss/comments.php?id=1887427 Sat, 18 Oct 2008 03:18:09 +0100 1887427 http://www.medworm.com/index.php?rid=1715338&cid=t_198489_132_f&fid=37823&url=http%3A%2F%2Fathena.bioc.uvic.ca%2Fnode%2F736 You can find a very cool movie showing the mechanism of entry at molecularmovies.org A narrated animation depicting the events that lead to Dengue virusentry into a host cell. In particular, rearrangements andconformational changes in the Dengue glycoprotein E are shown. These read more (Source: Bioinformaticians) Bioinformaticians blogs http://www.medworm.com/rss/comments.php?id=1715338 Wed, 06 Aug 2008 00:36:00 +0100 1715338