MedWorm provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest medical blog items that have been tagged with 'george church'. Sat, 03 Sep 2011 02:50:02 +0100 http://www.medworm.com/index.php?rid=2101474&cid=t_135215_131_f&fid=35743&url=http%3A%2F%2Fthegenesherpa.blogspot.com%2F2009%2F01%2Fanother-stephen-this-time-its-pinker.html No I don't spell my name with a ph, but that is just one of a few differences I have with Dr. Stephen Pinker(Erratum, turns out he spells it with a V, just like me. My Mistake) , one of the PGP 10. His article that I read on Saturday online is now being read by millions in print.Steven and I both are participating in Genomic Research. I haven't told many people, but I am a participant in the Coriell Personalized Medicine Collaborative. So I read his article with curiosity. Not only because he is a developmental psychologist, but also because he (like me) thinks that most behavior is inherited. So I wondered how his response to having his Exome released would further "shape him".....and thus when my results come in how will they "shape me"."All this sets the stage for what we can expect fro... Gene Sherpas: Personalized Medicine and You blogs http://www.medworm.com/rss/comments.php?id=2101474 Tue, 13 Jan 2009 11:05:00 +0100 2101474 http://www.medworm.com/index.php?rid=2053180&cid=t_135215_131_f&fid=35743&url=http%3A%2F%2Fthegenesherpa.blogspot.com%2F2008%2F12%2Fouch-cnv-with-lackluster-results.html All it takes is 2 seconds to step on some of my readership's toes and I feel it. Yesterday I posted on a 5% error rate for Whole Genome sequencing, I argued that even at 30x coverage it would not be ready for clinical diagnosis. I had CEOs of sequencing companies emailing me and VPs calling me. I even had pound for pound one of the best bloggers in the space say he was embarrassed for me.....Ouch!Why do I get pushback from people, when all I am doing is throwing some cold water on the party??? Get ready, because I am about to throw some more.....Remember yesterday when I said SNPs were one of 7 or 8 factors that will differentiate each of us??? Well, CNVs are another of those 7 or 8, 2 more include histone modification and methylation, telomerase activity and size would be another factor, ... Gene Sherpas: Personalized Medicine and You blogs http://www.medworm.com/rss/comments.php?id=2053180 Fri, 19 Dec 2008 11:06:00 +0100 2053180 http://www.medworm.com/index.php?rid=1397683&cid=t_135215_132_f&fid=35011&url=http%3A%2F%2Ffeeds.feedburner.com%2F%7Er%2Fmndoci%2F%7E3%2F277364755%2F Last evening, I had a chance to attend an interesing panel discussion on The Personal Genome. The Symposium featured Eric Lander, George Church, Leena Peltonen and Bill Gates and was moderated by Maynard Olson. My take away from the discussion, which was fueled by questions submitted by the audience and via the web, was that there is so much uncertainty at this time. We know so much, yet so little. At some level, we do not understand the implications of what we know, ethical and medical, at the same time, we underestimate the ability of our own genetics to withstand changes. Perhaps one of the things that jumped out at me was the general popular bbelief (which is hardly surprising) that it is a gene or a few genes that can be altered or fixed to address a “problem”. We’r... business|bytes|genes|molecules blogs http://www.medworm.com/rss/comments.php?id=1397683 Fri, 25 Apr 2008 03:36:19 +0100 1397683 http://www.medworm.com/index.php?rid=1252649&cid=t_135215_131_f&fid=35005&url=http%3A%2F%2Ffeeds.feedburner.com%2F%7Er%2Ffungalcompgenomics%2F%7E3%2F240095210%2F Definitely worth listening to the RadioLab show episode "So-Called Life". The second act describes some "MIT bioengineering kids" who engineered sweet smelling E.coli. I'm sure some of them interviewed hang out at OWW, like Reshma. The sound effects for gene exchange and "The BioEngineers song" at the end of the 2nd act is definitely worth listening to. Still trying to find a link to the song itsself. The third act talks with founder of Codon Devices, George Church, and Craig. They describe George "as Santa Clause as played by Clark Gable." We salute a show singing the praises of mighty microbes. © Jason Stajich for Fungal Genomes and Comparative Genomics, 2008. | Permalink | No comment Add to del.icio.us Search blogs linking this post with Technorati Want more on these top... Fungal Genomes and Comparative Genomics blogs http://www.medworm.com/rss/comments.php?id=1252649 Sat, 23 Feb 2008 21:57:03 +0100 1252649 http://www.medworm.com/index.php?rid=1198081&cid=t_135215_131_f&fid=35743&url=http%3A%2F%2Fthegenesherpa.blogspot.com%2F2008%2F02%2Fof-slelling-and-men.html Way back in 2004 I was bouncing off the ideas of Helix Health. My ex-partner and I even spoke of how great it would be to have datasets with genomes, biomarkers, physical exam and medical history data. We posited how great it would be to sell these datasets to pharma.....We even thought about creating a CRO to carry out the genetic integration of pharma testing creating PGx specialized research.I only mention this because I got a little blasted for tying 23andME with Tuskegee. Well, not really blasting, just a blog post from a really great new blog called Genetic Future.First, we said "Is this a viable business model?" The answer, a resounding yesSecond we said "Will patients be ok with us giving their data to Pharma companies?" The answer, maybe...but only if they received something back.... Gene Sherpas: Personalized Medicine and You blogs http://www.medworm.com/rss/comments.php?id=1198081 Sun, 03 Feb 2008 14:51:00 +0100 1198081 http://www.medworm.com/index.php?rid=1196003&cid=t_135215_131_f&fid=35743&url=http%3A%2F%2Fthegenesherpa.blogspot.com%2F2008%2F02%2Fgetting-band-back-together.html The Sherpa is back....and with a vengeance. First, thank you to all who wished myself and my family well. We are doing fine. The family had a member get struck with cancer. It never ceases to amaze me how this horrible disease can bring families to their knees. I look forward to the day which we can detect these malignancies prior to their metastases. Even better, before they ever start.I just spent the afternoon with Genome-Boy Misha Angrist. With Bertalan Mesko coming on Monday I feel like the Blues Brothers. Misha and I had a fun filled lunch and interview. I can't be sure who was interviewing whom, but I am certain both of us walked away more informed. I honestly admire those 10 PGP'ers. Imagine not knowing that these corporate genomics companies would be making such a huge imprint on ... Gene Sherpas: Personalized Medicine and You blogs http://www.medworm.com/rss/comments.php?id=1196003 Fri, 01 Feb 2008 22:00:00 +0100 1196003 http://www.medworm.com/index.php?rid=944703&cid=t_135215_131_f&fid=35743&url=http%3A%2F%2Fthegenesherpa.blogspot.com%2F2007%2F10%2Finteresting-readers.html Over the last week I have been working on a little personal genome search project. I was contacted by one of my readers to help her find someone to "donate" her genome to. Initially I was surprised to receive such a request. Especially because I have railed against using the genome for a crystal ball.But she was vehement that she wanted to donate her genome. Now I Have to tell you that I was then convinced of her altruism. She didn't know where to turn so we began with the usual suspects Dr Church, Dr Collins, Dr Rothberg, Hodosh. But when we were turned away a window opened.I turns out Dr Venter's Institute is looking to turn out 10k genomes in 10 years. The perfect project.....provided these subjects have appropriate care providers to help out......Since Helix Health is taking patients n... Gene Sherpas: Personalized Medicine and You blogs http://www.medworm.com/rss/comments.php?id=944703 Thu, 11 Oct 2007 22:17:00 +0100 944703 http://www.medworm.com/index.php?rid=869670&cid=t_135215_131_f&fid=35743&url=http%3A%2F%2Fthegenesherpa.blogspot.com%2F2007%2F09%2Fattorney-general-genetic-counselor-and.html Today my phone blew up. I had five different Venture Capital firms call me to pick my brain about "The New deal with Illumina" as well as "Viability of Microarrays in Pharmaceuticals"I must say thank you to those who called. I look forward to speaking with each of your esteemed groups.That being said......I must say that there is a general consensus of the physician side that the time for whole genome analysis for your health is not now. I agree. An excellent scientist Dr Bettinger over at the Genetic Genealogist posed a great question."What is your opinion on Gap Phase?....." "that inevitably long period of time between (1) the availability of inexpensive whole-genome sequencing, and (2) the point when the medical field produces enough specialists in genetics to handle the work load." Wel... Gene Sherpas: Personalized Medicine and You blogs http://www.medworm.com/rss/comments.php?id=869670 Thu, 13 Sep 2007 23:47:00 +0100 869670 http://www.medworm.com/index.php?rid=856908&cid=t_135215_131_f&fid=35743&url=http%3A%2F%2Fthegenesherpa.blogspot.com%2F2007%2F09%2Fgene-genie-and-georges-blog.html First....Gene Genie is up at Cancer Genetics. Thanks to Ramunas who put up an excellent edition!!Second and even more importantly......My excellent Chief of Genetic Counseling brought George Church's blog to my attention. My gosh....His evaluation is right on point. His question is a wonderful one...... Great now we have genomes....so what. How do we get to systems biology? Once we have systems biology on point, we will then have truly personalized medicine. We will be able to manipulate the systems....and physicians will become engineers, systems analysts....So when will we get there? How will we get there? My gut says there are 25 different signalling systems and perhaps four different common pathways....these will corroborate with the 4 humours........ Welcome back Galen and great to se... Gene Sherpas: Personalized Medicine and You blogs http://www.medworm.com/rss/comments.php?id=856908 Mon, 10 Sep 2007 01:31:00 +0100 856908 http://www.medworm.com/index.php?rid=765052&cid=t_135215_131_f&fid=35743&url=http%3A%2F%2Fthegenesherpa.blogspot.com%2F2007%2F07%2Fwhat-good-is-map.html Imagine being stranded on a raft......An object is floating in the water. You paddle hard to get it. Once you do, you realize its a map. Hooray, you can finally find some land. Or can you? There are some significant questions to ask yourself prior to having any utility gained from that map.Can you read the map? I used to be in the Navy. We learned how to read nautical maps. But my father, a retired colonel in the Army, would have no clue where to begin. Imagine someone who had no training......Where are you on that map? If you have no orientation, how could you hope to navigate. Where does the sun rise? Simple question. However, when asked almost 15% of Americans do not know the answer. What is on the land you will be paddling to? If you paddle hard to get there only to find out that there... Gene Sherpas: Personalized Medicine and You blogs http://www.medworm.com/rss/comments.php?id=765052 Sun, 29 Jul 2007 15:59:00 +0100 765052 http://www.medworm.com/index.php?rid=763180&cid=t_135215_131_f&fid=35743&url=http%3A%2F%2Fthegenesherpa.blogspot.com%2F2007%2F07%2Fwhy-cant-we-be-friends.html This study was performed on the famed Framingham Heart Study offspring. They attempted to control environment by evaluating neighbors. It does turn out that there is no relation between neighbors and obesity.....Unless they are friends...This tells us that social networking is an indicator of risk of disease. Intuitively this makes sense. Smokers hang together, as do illicit drug users, and perhaps as this study shows over-eaters. Why can't we be friends? Because you are fat. (Source: Gene Sherpas: Personalized Medicine and You) Gene Sherpas: Personalized Medicine and You blogs http://www.medworm.com/rss/comments.php?id=763180 Fri, 27 Jul 2007 21:17:00 +0100 763180