MedWorm provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest medical blog items that have been tagged with 'glaxo'. Sat, 03 Sep 2011 02:01:49 +0100 http://www.medworm.com/index.php?rid=5051166&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2011%2F07%2F22%2Fthe-murdochs-and-glaxo-the-parallels%2F I’ve been following the News International story with great interest. What surprised me today is the news that people think it’s wrong that James Murdoch paid off Gordon Taylor (£700,000 according to some estimates) and  included a gagging order in the agreement to stop the truth from coming out. Of course, Murdoch did this long before the details of the case were in the public domain, so he was spending big in order to try and avoid exactly what’s happening at this very moment. There seems to be outrgage that someone would do such a thing… well, I’ve got news for you – Glaxo has been doing for years and still does.. Here’s an old post from 2007: Buying our silence Buying our silence – that’s what it’s all about when Glaxo opens its cheque... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=5051166 Fri, 22 Jul 2011 13:37:12 +0100 5051166 http://www.medworm.com/index.php?rid=4747613&cid=t_113167_87_f&fid=39187&url=http%3A%2F%2Fgetbetterhealth.com%2Fanalgesic-powder-a-southern-cultural-tradition-being-discontinued-by-gsk%2F2011.04.25 After spending the first 21 years of life in New Jersey and Philadelphia, I ventured to the University of Florida for graduate school. For those who don’t know, UF is in the north-central Florida city of Gainesville – culturally much more like idyllic south Georgia than flashy south Florida. It was in Gainesville – “Hogtown” to some – that I first encountered the analgesic powder. I believe it was BC Powder, first manufactured just over 100 years ago within a stone’s throw of the Durham, NC, baseball park made famous by the movie, Bull Durham. I remember sitting with my grad school buddy from Kansas City watching this TV commercial with hardy men possessing strong Southern accents enthusiastically espousing the benefits of BC. I looked at Roger – a registered pharmacist –... Better Health blogs http://www.medworm.com/rss/comments.php?id=4747613 Mon, 25 Apr 2011 13:00:27 +0100 4747613 http://www.medworm.com/index.php?rid=4429190&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2011%2F02%2F02%2Fexplaining-the-rise-in-antidepressant-prescribing-or-not%2F Ben Goldacre pointed out this new research in the BMJ – Explaining the rise in antidepressant prescribing. It seems the research shows that the rise in antidepressant prescribing is nothing to do with new prescriptions, rather it’s due to more people being on the drugs for longer “The rise in antidepressant prescribing is mainly explained by small changes in the proportion of patients receiving long term treatment.” [It should be noted that the research is 5 years out of date already as the years covered are 1993 - 2005]. Hmmmm. If that’s the case, I wonder if any research has been done into possible harm due to long-term SSRI use – by Glaxo maybe? Or Pfizer perhaps? I wonder if patients find, when they try to stop taking SSRIs, they can’t because ... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=4429190 Wed, 02 Feb 2011 19:11:55 +0100 4429190 http://www.medworm.com/index.php?rid=4372233&cid=t_113167_140_f&fid=35772&url=http%3A%2F%2Fshutah.wordpress.com%2F2011%2F01%2F19%2Fglaxo-stung-by-legal-bill%2F GSK shareholders are hit by costly legal settlements. If big really is beautiful, then you don’t get much more attractive than pharmaceutical giantGlaxoSmithKline Glaxo the global giant By any measure, GSK is a powerhouse. The world’s fourth-largest drug-maker recorded annual sales of over £28 billion in 2009 and posted a post-tax profit of £5.7 billion. GSK employs nearly 100,000 people and paid over £2.2 billion in corporate taxes last year, so it’s one of the biggest corporate contributors to HM Treasury’s coffers. Furthermore, with a market capitalisation of over £61 billion, the blue-chip firm’s shares are very widely held, featuring at the heart of many UK-focused portfolios, both private and institutional. So, when GSK stumbles, it has an impact on ... SEROXAT WEBLOG blogs http://www.medworm.com/rss/comments.php?id=4372233 Wed, 19 Jan 2011 23:59:09 +0100 4372233 http://www.medworm.com/index.php?rid=4305087&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2011%2F01%2F03%2F60-minutes-and-glaxosmithklines-whistleblower%2F Yet another ‘how does Glaxo get away with it’ story…. Cheryl Eckards’ job, as manager of Glaxo’s global quality assurance, “was to inspect plants to make sure that the drugs had the right ingredients, the right potency and met government standards for purity.” In fact, she was sent in because an FDA inspection had already seen problems as this plant [Cidra] (noting that “FDA inspections of drug plants are only occasional, so it’s up to drug companies to police themselves” – which is why litigation is such a critical backup.)  But as 60 Minutes put it, Eckard “found much more than the FDA had.”  For example, The employees were contaminating products, including the anti-bacterial ointment Bactroban, which was made in a sealed tank to prevent co... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=4305087 Mon, 03 Jan 2011 14:10:36 +0100 4305087 http://www.medworm.com/index.php?rid=4266190&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2010%2F12%2F18%2F20-years-of-pharmaceutical-company-fraud%2F How much longer will big pharma be allowed to get away with it? Something’s got to change, because along with all the settlements shown below, the pharmaceutical industry is responsible for killing thousands of patients each year. You’ll see from the chart that the last few years have been the worst for settlements – the reason is that the pharmaceutical companies that are all too happy to create drugs (and aggressively market those drugs) in the knowledge that the drugs are unsafe – putting their wealth before patients’ health. The age of the truly innovative blockbuster drug is over – Big Pharma knows this but continues to market sub standard products to the public. This is also the reason why we have seen marketing and advertising spend leap ahead of (by two ... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=4266190 Sat, 18 Dec 2010 10:39:02 +0100 4266190 http://www.medworm.com/index.php?rid=4251253&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2010%2F12%2F11%2Fchuck-nemeroff-really-really-pissed-off-but-still-really-really-rich%2F Did I mention the textbook that Chuck Nemeroff wrote, oops – or rather he didn’t, but he might have done, or at least he might have seen some drafts and approved them… who knows? Probably not Chuck  because his memory is so bad – maybe that’s why he forgot to disclose all that cash he got from drug companies (wasn’t it about $1.5 million?). That’s one poor memory! Anyway, now he’s really pissed off and wants to sue POGO because they ran a story about the ghostwritten Nemeroff textbook – and so did the the New York Times in their story: Drug Maker Wrote Book Under 2 Doctors’ Names, Documents Say Here are some downloads for you while away the long winter hours with – thanks to 1 Boring Old Man POGO Letter to NIH on Ghostwritin... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=4251253 Sat, 11 Dec 2010 15:53:29 +0100 4251253 http://www.medworm.com/index.php?rid=4214440&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2010%2F11%2F30%2Fthe-book-that-chuck-nemeroff-did-not-write%2F I think we all know about Professor Chuck Nemeroff and his links with big pharma – if the price is right he’ll sell anything for you. We know he’s put his name to ‘research’ papers that have been written by medical PR firms (ghostwriting). But an entire book….??!! Thanks to Dr Ben Goldacre for this. From the New York Times: Drug Maker Wrote Book Under 2 Doctors’ Names, Documents Say Two prominent authors of a 1999 book teaching family doctors how to treat psychiatric disorders provided acknowledgment in the preface for an “unrestricted educational grant” from a major pharmaceutical company – Glaxo. But the drug maker, then known as SmithKline Beecham, actually had much more involvement than the book described, newly disclosed documents show. ... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=4214440 Tue, 30 Nov 2010 19:59:49 +0100 4214440 http://www.medworm.com/index.php?rid=4133716&cid=t_113167_87_f&fid=39261&url=http%3A%2F%2Fvactruth.com%2F2010%2F11%2F02%2Fglaxo-smith-kline-brainwash-doctors-hpv-vaccine%2F In June 2008 a promotional DVD was sent to every General Practitioner (G.P.) in the UK just hours before the launch of the Cervarix vaccine in the UK. The DVD was posted with the G.P. magazine and was a clever marketing strategy aimed at busy G.P.’s to ‘brainwash‘ them into believing that the Cervarix vaccine protected young women from the perils of cervical cancer. With phrases such as ‘Cervarix, the vaccination to prevent cervical cancer’ and convincing animation, the DVD certainly goes all out to convince the medical profession that the vaccine is safe, effective, and a must for all young women. One organisation that promotes vaccination safety S.A.N.E Vax Inc (http://sanevax.org/) (Safe, Affordable, Necessary and Effective Vaccines) were so shocked at what... vactruth.com blogs http://www.medworm.com/rss/comments.php?id=4133716 Tue, 02 Nov 2010 19:54:02 +0100 4133716 http://www.medworm.com/index.php?rid=4119700&cid=t_113167_150_f&fid=34768&url=http%3A%2F%2Fpharmagossip.blogspot.com%2F2010%2F10%2Fpharma-giles-writes-about-gsk-affair.html http://pharmagiles.blogspot.com/2010/10/gotcha.htmlLOL (Source: PharmaGossip) PharmaGossip blogs http://www.medworm.com/rss/comments.php?id=4119700 Fri, 29 Oct 2010 06:23:00 +0100 4119700 http://www.medworm.com/index.php?rid=4118765&cid=t_113167_83_f&fid=34856&url=http%3A%2F%2Finsidesurgery.com%2F2010%2F10%2Fglaxo-fined-750-million-adulterated-drug-case%2F The pharmaceutical giant GlaxoSmithKline has received a $750 million fine for producing adulterated and unsafe drugs at a plant in Puerto Rico. The settlement covers the faulty manufacture of the drugs Kytril, Bactroban, Paxil CR, and Avadament. Cheryl Eckard, the whistleblower responsible for uncovering the unsafe drug manufacturing, will receive $96 million out of the fine amount. (Source: Inside Surgery) Inside Surgery blogs http://www.medworm.com/rss/comments.php?id=4118765 Tue, 26 Oct 2010 22:59:11 +0100 4118765 http://www.medworm.com/index.php?rid=4018430&cid=t_113167_147_f&fid=39273&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FePharmaSummit%2F%7E3%2FTUXKopJ_L3I%2Fmia-hamm-promotes-give-your-health-shot.html Soccer Player Mia Hamm is working with GlaxoSmithKline to promote the awareness of vaccination health for adults. Reported by MM&M, With the "Give Your Health A Shot" campaign, GSK is looking to spread awareness of the 14 vaccinations that can prevent serious illness in adults. In order to reach their target audience, GSK is using http://www.giveyourhealthashot.com website as well as a 30 minute public service announcement that will run in select markets throughout the month of October. (Source: ePharma Summit) ePharma Summit blogs http://www.medworm.com/rss/comments.php?id=4018430 Thu, 30 Sep 2010 15:12:00 +0100 4018430 http://www.medworm.com/index.php?rid=3867068&cid=t_113167_167_f&fid=38271&url=http%3A%2F%2Frebeccascritchfield.wordpress.com%2F2010%2F08%2F15%2Fsupplement-scandals%2F By Carlene Helble-Elite Nutrition Intern More supplement issues in the news? I can’t say I’m surprised. With a lack of the tight restrictions that prescription drugs have, supplements can do things like: make broad health claims as long as they don’t say they are a ‘cure’ avoid sending clinical trials to the FDA to prove the safety of a product This week, a supplement scandal emerged involving an ethical question. Can pharmaceutical executives have personal side ventures in which they sell compound X as a supplement? What about while the pharmaceutical company is still running clinical trials on the same compound as a prescription cancer treatment? British pharmaceutical company GlaxoSmithKline found itself in the news this past Thursday after telling two employees to ‘dista... Balanced Health and Nutrition Rebecca Scritchfield's Blog blogs http://www.medworm.com/rss/comments.php?id=3867068 Sun, 15 Aug 2010 02:47:28 +0100 3867068 http://www.medworm.com/index.php?rid=3806027&cid=t_113167_150_f&fid=38374&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FePharmaSummit%2F%7E3%2FwyHlOgbofe0%2Fgsks-sales-reps-have-new-targets.html GSK's sales reps will soon be rewarded for the number of relationships they form with doctors instead of the number of drugs they sell. Bonuses will be based on the "individual achievements of sales targets." Read the full article at MM&M.How do you think this will affect the overall industry? (Source: ePharma Summit) ePharma Summit blogs http://www.medworm.com/rss/comments.php?id=3806027 Fri, 30 Jul 2010 14:50:00 +0100 3806027 http://www.medworm.com/index.php?rid=3780545&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2010%2F07%2F22%2Fvisit-these-sites-for-all-your-seroxatpaxil-information%2F A quick and unashamed plug for a couple of blogs that I hope you are all regular readers of… Seroxat Sufferers and GSK: Licence to (K)ill I am always amazed by the sheer amount of work that Bob Fiddaman at Seroxat Sufferers puts in and if you check out GSK: Licence to (K)ill you will find one of the best set of links in the business in the Blogroll that the Truthman has put together. I thank you. (Source: seroxat secrets...) seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=3780545 Thu, 22 Jul 2010 12:31:29 +0100 3780545 http://www.medworm.com/index.php?rid=3780546&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2010%2F07%2F22%2Ffda-avandia-panel-member-failed-to-disclose-he-was-on-glaxos-payroll%2F … and guess which way he voted?? In fact the panel member in question, David Capuzzi, was one of only three experts who voted for Avandia to stay on the market with no additional warnings. Not a conflict of interests, oh no, of course not!!?? This from Jim Edwards at BNET UK: The news that one of the doctors on an FDA panel assessing whether GlaxoSmithKline (GSK)’s diabetes drug Avandia causes too many heart attacks failed to disclose he was a paid speaker for the company points out a giant hole in the FDA’s regulations: The disclosure form that outside experts who advise the FDA on risky drugs are required to sign only requires experts to list fees from speaking or writing  for a drug company for the “Last 12 months or under negotiation.” That’s too short a time period to... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=3780546 Thu, 22 Jul 2010 12:17:05 +0100 3780546 http://www.medworm.com/index.php?rid=3710769&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2010%2F06%2F29%2Fsara-carlin-death-by-paxil%2F I came across the above named video, ‘Sara Carlin – death by Paxil’, on Bob Fiddaman’s website Seroxat Sufferers. Bob has been following the inquest into the death of Sara Carlin. Yesterday the jury returned its findings. In a  phone conversation between Neil Carlin (Sara’s father) and Bob, Neil explained that both he and his wife “…are extremely pleased with the outcome of the inquest into our beloved Sara’s Paxil related suicide with the recommendations that the jury have given in their verdict.” He added, “The jury were under very strict restraints in their ability to name or blame any party in this inquest, including the three doctors from Oakville Ontario Canada – and the drug company GlaxoSmithKline – maker of the S... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=3710769 Tue, 29 Jun 2010 14:34:47 +0100 3710769 http://www.medworm.com/index.php?rid=3659134&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2010%2F06%2F14%2Fthe-mhra-and-glaxos-solicitiors-just-how-close-are-they%2F There’s some very interesting news at Seroxat Sufferers. Bob Fiddaman has been writing a series of posts about the identities of the expert witnesses that Glaxo are using to defend themselves against the High Court action. It’s all a bit too cosy and I defy anyone to describe Glaxo’s experts as independent (which they should be under English law). Anyway, last Friday afternoon Bob noticed some visits to his blog – at 16.37hrs the MHRA looked in and started read the posts about Glaxo’s ‘independent’ witnesses – then 41 seconds later, in what could only be a coincidence of the most massive proportions, you can see Glaxo’s solicitors Addleshaw Goddard, reading the exact same post. I wonder what the chances are of that happening? Millions t... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=3659134 Mon, 14 Jun 2010 09:41:02 +0100 3659134 http://www.medworm.com/index.php?rid=3589035&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2010%2F05%2F22%2Fglaxo-is-still-testing-paxil-on-7-year-olds-despite-proven-suicide-risks%2F This story just shows little Glaxo cares and what a thick skin the drugs giant has. It’s from BNET UK by Jim Edwards. Bob Fiddaman over at Seroxat Sufferers has also picked up on this and gone straight for the jugular (in his usual fashion!) writing to Glaxo demanding a full explanation: “As a matter of public record I would like either GlaxoSmithKline UK or GlaxoSmithKline Japan to explain why this study has been put in place. In other words, what is GlaxoSmithKline’s motive behind this study?” Bob and I have been doing this for all too long and I don’t think either of us will be holding our breath waiting for any sort of reply from Glaxo. Here’s the Jim Edwards piece: It was established years ago that Paxil carries a risk of suicide in children and te... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=3589035 Sat, 22 May 2010 07:24:20 +0100 3589035 http://www.medworm.com/index.php?rid=3276067&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2010%2F02%2F16%2Fpaxil-birth-defect-litigation-glaxos-dirty-secrets-come-to-light-during-first-trial%2F This from Evelyn Pringle: Feb. 15, 2010 – GlaxoSmithKline has paid out close to $1 billion to resolve lawsuits involving Paxil since the drug came on the market in1992, according to a December 14, 2009 Bloomberg report. But the billion dollars does not cover the more than 600 Paxil birth defect cases currently pending in multi-litigation in Pennsylvania. Glaxo has settled about 10 birth defect cases, according to Sean Tracey, a Houston attorney who represented the family of a child victim in the first jury trial that decided in favor of the plaintiff on October 13, 2009, Bloomberg reports. The settlements in those lawsuits averaged about $4 million, people familiar with the cases told the new service. First Trial A Bust for Glaxo The first trial, in the case of Kilker v Glaxo, ended ... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=3276067 Tue, 16 Feb 2010 07:30:41 +0100 3276067 http://www.medworm.com/index.php?rid=3153630&cid=t_113167_150_f&fid=38374&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FePharmaSummit%2F%7E3%2FiOJS9qmBLf4%2Fdiet-drug-maker-glaxo-to-pay-for-film.html (Source: ePharma Summit) ePharma Summit blogs http://www.medworm.com/rss/comments.php?id=3153630 Fri, 08 Jan 2010 16:41:00 +0100 3153630 http://www.medworm.com/index.php?rid=3133793&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2009%2F12%2F30%2Fthe-seroxat-paxil-pil-over-the-years-ch-ch-ch-changes%2F It’s at this time of year that we all look forward to a new decade and look back on the years that have brought us to where we are today. I thought it would be useful to look back at 20 years of Glaxo spin – to review the information supplied by Glaxo over the past 20 years to patients like you and me. The PIL – the Patient Information Leaflet is what I’m talking about. As you download the PDFs and read them, please remember each of the leaflets is referring to EXACTLY the same drug – hard to believe. I’m very happy to be able to supply what is a truly historic document – the very first Seroxat PIL – click on the link to download it – Original Seroxat PIL 1990. This is a relic of a bygone age – a much simpler time for all of us. D... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=3133793 Wed, 30 Dec 2009 17:39:33 +0100 3133793 http://www.medworm.com/index.php?rid=2989388&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2009%2F11%2F13%2Fcharles-chuck-nemeroff-lands-on-his-feet%2F Chuck Nemeroff, the controversial former Emory University psychiatry department chair, has been named chair of the psychiatry department at the University of Miami School of Medicine – has the man got no shame? It was only October last year that Chuck was forced to resign from Brown University. Phil Dawdy at Furious Seasons summed it up like this: A few of you have probably already caught the news elsewhere: yesterday, Charles Nemeroff resigned as chair of the psychiatry department at Emory University. The move came on the heels of revelations that he’d taken in $2.8 million in pharma consulting monies since 2000, but had only reported less than half of that–all while taking NIH research grants on the other hand and assuring his university that he was taking in less than $10,000 ... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=2989388 Fri, 13 Nov 2009 13:56:20 +0100 2989388 http://www.medworm.com/index.php?rid=2899181&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2009%2F10%2F15%2Fcourt-transcripts-hosted-here-glaxo-guilty-of-not-warning-of-the-dangers-of-seroxat-to-pregnant-women%2F After analyzing a 2001 e-mail from a Paxil user who aborted her fetus because it had a heart defect, Glaxo officials noted in company files they were “almost certain” the drug was related to the problem, Jane Nieman, a former Glaxo drug-safety executive, told a Pennsylvania jury. Now that Glaxo has been found guilty and Kilker case has ended, pending an appeal of course,  what of the remaining court documents that have yet to surface? READ THEM ALL HERE! (Source: seroxat secrets...) seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=2899181 Thu, 15 Oct 2009 20:46:37 +0100 2899181 http://www.medworm.com/index.php?rid=2899182&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2009%2F10%2F15%2Fseroxat-no-really-its-safe-all-that-happened-was-someone-ticked-the-wrong-box-on-a-form-says-glaxo%2F This report was received from the patient and has not been confirmed by a physician or other health care professional. Concurrent medications and medical conditions were not known. “Four-and-a-half years ago, the patient started Paxil (dose unknown). Since taking Paxil, the patient noted she has been panic-free and has been able to go on with a normal life. “Patient discovered she was pregnant in December 2000 while being treated with Paxil. However, she reported that at six months gestation the pregnancy had to be terminated because the fetus was diagnosed as having Truncus arteriosis. “Her physician told her that the child would not lead a normal childhood and would most likely not make it through the open heart surgery that he would need as soon as he was delivered, if... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=2899182 Thu, 15 Oct 2009 18:25:48 +0100 2899182 http://www.medworm.com/index.php?rid=2894759&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2009%2F10%2F14%2Fseroxat-paxil-to-blame-for-babys-heart-defects-american-jury-rules%2F This from Sarah Boseley at the Guardian: A family has been awarded $2.5m (£1.6m) in damages after a jury in Philadelphia decided that the British-made antidepressant Seroxat was responsible for their three-year-old son’s heart defects. GlaxoSmithKline, the British manufacturer of Seroxat, known as Paxil in the US, said it would appeal against the verdict. Although drug regulators in the US and UK warned in 2005 that Seroxat could be linked to heart defects, GSK does not accept its drug is the cause. Thousands of women worldwide have taken antidepressants such as Seroxat in pregnancy, assured by manufacturers and doctors that they are safe. The case is one of a number in the US and the first to end in a verdict against the company. Michelle David, 24, was prescribed Paxil in the US a... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=2894759 Wed, 14 Oct 2009 20:40:57 +0100 2894759 http://www.medworm.com/index.php?rid=2809879&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2009%2F09%2F19%2Fbritish-doctor-faces-action-over-claims-of-ghost-writing-for-us-drug-company%2F What is ‘ghostwriting’? How far will drug companies go to market their products to an unsuspecting and trusting public? This from Sarah Boseley at the Guardian will explain all: Doctors have been agreeing to be named as authors on studies written by employees of the pharmaceutical industry, giving greater credibility to medical research, according to new evidence. The Guardian has learned that one of Britain’s leading bone specialists is facing disciplinary action over accusations that he was involved in “ghost writing”. The wider phenomenon has come to light through documents disclosed in the US courts which have revealed a culture in which doctors agree to “author” studies written by employees of drug firms. The doctors may have some input but do... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=2809879 Sat, 19 Sep 2009 11:23:15 +0100 2809879 http://www.medworm.com/index.php?rid=2807867&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2009%2F09%2F18%2Finternal-email-shows-glaxo-linked-birth-defect-of-fetus-to-paxilseroxat%2F More from Glaxo’s current trial in the USA. This from Jef Feeley and Sophia Pearson at Bloomberg: Sept. 18 — Officials of GlaxoSmithKline Plc, the U.K.’s largest drugmaker, said in 2001 that a birth defect in the fetus of a woman taking its Paxil antidepressant likely was linked to the drug, according to court testimony. After analyzing a 2001 e-mail from a Paxil user who aborted her fetus because it had a heart defect, Glaxo officials noted in company files they were “almost certain” the drug was related to the problem, Jane Nieman, a former Glaxo drug-safety executive, told a Pennsylvania jury. “I don’t know who made that assessment, but it’s there,” Nieman testified in a videotaped deposition played yesterday for jurors. Nieman’s testimony came in the tr... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=2807867 Fri, 18 Sep 2009 07:16:37 +0100 2807867 http://www.medworm.com/index.php?rid=2800679&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2009%2F09%2F16%2F%25e2%2580%259cif-neg-results-can-bury-%25e2%2580%259d-writes-glaxo-executive-about-paxilseroxat%2F The Philadelphia trial has barely begun and already we are learning more about the way Glaxo does business… rigged drug trials, hidden negative data and fraudulent marketing would seem to be the order of the day once more. I wonder what new secrets will be revealed next year in London, when Glaxo faces yet more patients injured by Seroxat in the High Court… Here’s the latest from Bloomberg : Glaxo Executive’s Memo Suggested Burying Drug Studies By Jef Feeley and Margaret Cronin Fisk Sept. 15 (Bloomberg) — An executive of GlaxoSmithKline Plc, the world’s second-biggest drugmaker, talked about burying negative studies linking its antidepressant drug Paxil to birth defects, according to a company memo introduced at a trial. “If neg, results can bury,” Glaxo ... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=2800679 Wed, 16 Sep 2009 08:25:27 +0100 2800679 http://www.medworm.com/index.php?rid=2786254&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2009%2F09%2F11%2Fglaxo-in-court-next-week-previously-secret-internal-company-documents-show-glaxo-hid-adverse-data-once-again%2F This from Bloomberg.com via the Truthman: GlaxoSmithKline to Defend Paxil in Birth Defect Test-Case Trial By Sophia Pearson and Margaret Cronin Fisk Sept. 11 (Bloomberg) — GlaxoSmithKline Plc, the world’s second-biggest drugmaker, begins a trial in Philadelphia next week in what may be a test case for more than 600 lawsuits over claims its antidepressant drug Paxil causes birth defects. Patients and their parents claim internal company documents produced for trial show Glaxo failed to warn about the risks of Paxil until forced to do so in 2005 by the U.S. Food and Drug Administration. In a trial set for Sept. 14, Michelle David blames the drug for causing life-threatening heart defects in her son Lyam Kilker, 3. The London-based company faces two more such trials a month from Oct... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=2786254 Fri, 11 Sep 2009 17:32:27 +0100 2786254 http://www.medworm.com/index.php?rid=2682118&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2009%2F08%2F08%2Fseroxatpaxil-%25e2%2580%2593-the-new-thalidomide-%25e2%2580%2593-part-3%2F Part 3 of this story… Seroxat/Paxil – the new Thalidomide? Seroxat/Paxil – the new Thalidomide? – part 2 Reading the above stories (and from doing a little reasearch online), it would seem to me that, at the very least, Glaxo would err on the side of caution and advise that pregnancy and Seroxat/Paxil perhaps do not mix – they might say the jury was out, but at least be advised they might be a problem. That would be safe, reasonable and logical you would think. But no. Glaxo are instead trying to create a new market from Paxil/Seroxat – as a treatment for premenstrual dysphoric disorder… the clincial trials they have funded say just take Seroxat/Paxil for a few days each month and all will be well! Honestly, from my own experience (and the experience of tens ... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=2682118 Sat, 08 Aug 2009 09:25:24 +0100 2682118 http://www.medworm.com/index.php?rid=2682120&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2009%2F08%2F07%2Fseroxatpaxil-the-new-thalidomide%2F This from Sarah Boseley at the Guardian: Antidepressants once seen as miracle drugs: now risks are becoming evident US courts to hear claims that insufficient attention was paid to dangers to foetus Since the horror of the Thalidomide scandal in the 1960s, pharmaceutical companies and medicines regulators have been acutely aware of the dangers drugs may pose to the unborn child. Establishing what the effect of a drug may be on a foetus, however, is no simple task. Companies must rely on animal studies in the early stages of research and hope that the drug will behave in humans in the same way. Trials on pregnant women are rarely carried out, for obvious reasons. Depression and anxiety became big business for the pharmaceutical industry in the 1990s as doctors became better at diagnosing th... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=2682120 Fri, 07 Aug 2009 22:05:20 +0100 2682120 http://www.medworm.com/index.php?rid=2513067&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2009%2F06%2F19%2Fthe-truth-about-how-addictive-seroxat-paxil-is%2F Well not actually the truth, I’m afraid – read on and you’ll see Glaxo actually has a couple of conflicting things to say Seroxat and addiction – and they both can’t be truth. You might think that after all the years of doctors and patients all around the world saying Seroxat is highly addictive – oops, sorry, causes dependence and severe withdrawal reactions – that Glaxo would simply undertake the definitive study to prove us all wrong and to really show the world once and for all  how safe and non-addictive Seroxat is… Glaxo could have done this years ago but it has not. In fact, the official Paxil prescribing information (produced by Glaxo, current version) confirms this by saying: DRUG ABUSE AND DEPENDENCE Controlled Substance Class: PAXIL is not a ... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=2513067 Fri, 19 Jun 2009 13:07:16 +0100 2513067 http://www.medworm.com/index.php?rid=2513152&cid=t_113167_150_f&fid=38374&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FEPharmaSummit%2F%7E3%2FpQvanQjBFDU%2Fcompanies-that-have-jumped-into-online.html (Source: ePharma Summit) ePharma Summit blogs http://www.medworm.com/rss/comments.php?id=2513152 Wed, 17 Jun 2009 15:19:00 +0100 2513152 http://www.medworm.com/index.php?rid=1960761&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2008%2F11%2F13%2Fmore-on-marty-keller-and-his-lies-does-this-man-have-no-conscience%2F I’m just catching up here with a post about the lying, cheating, son-of-a-bitch Dr Martin Keller (…so sue me Marty…) This from Alison Bass, author of Side Effects, the book which covers the whole sordid affair of Keller’s Paxil Study 329, the most infamous fraudulent pediatric trial of all time. The study “offers a landmark for the point at which science turned into marketing,” according to Dr David Healy: When I was a reporter for The Boston Globe in the 90s, an employee of Brown University’s department of psychiatry handed me a raft of internal university documents. A number of these documents pertained to an ongoing clinical trial that compared the antidepressant Paxil to a placebo and older antidepresssant (imipramine) in the treatment of depression in... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=1960761 Thu, 13 Nov 2008 21:47:50 +0100 1960761 http://www.medworm.com/index.php?rid=1926536&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2008%2F11%2F02%2Fchange-pharmacovigilance-reporting-rules-uk-govt-is-told%2F This story makes me laugh - the UK goverment has been told by the EU that the law needs to be changed to make it clearer to drugmakers when they should report new information which might influence the evaluation of a medicine’s risks and benefits to the Medicines and Healthcare products Regulatory Agency, the government has been told. What I find so risable is the suggestion that there needs to be a law to ensure drug companies keep patients safe - that’s what it boils down to - “…report new information which might influence the evaluation of a medicine’s risks and benefits…” This law change comes as a direct result of the 4 year criminal investigation into Glaxo and the way the company hid negative trial data from the regulator and the public in order not... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=1926536 Sun, 02 Nov 2008 10:41:01 +0100 1926536 http://www.medworm.com/index.php?rid=1856083&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2008%2F10%2F06%2Fcharles-nemeroff-resigns-from-emory-university-thats-not-the-end-of-it-though%2F So, we say farwell to Chuck “Bling Bling” Nemeroff as he resigns from Emory. Sorry Chuck, but it’s too little too late. You’ve done the damage already by talking up shitty drugs and crappy research. If you think this is over now, you’ve got another think coming - the time is right to finally bring a so-called Key Opinion Leader to account for his lies. I hope Senator Grassley agrees with me. If we’re going to put a stop to KOLs selling their reputations to the highest bidders then we need an example to be made of someone. It seems Senator Grassley has the evidence against Nemeroff to do this - does he have the nerve, I wonder? This from Phil Dawdy at Furious Seasons: A few of you have probably already caught the news elsewhere: yesterday, Charles Nemerof... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=1856083 Mon, 06 Oct 2008 12:52:07 +0100 1856083 http://www.medworm.com/index.php?rid=1646011&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2008%2F07%2F23%2Flilly-zyprexa-glaxo-seroxat%2F I notice that Phil Dawdy at Furious Seasons has an update on the Zyprexa story. I’ve written about Zyprexa before but Phil is the Daddy on this one. In March 2007, I wondered “how does a drug such as Zyprexa, that was approved for the treatment of adults with schizophrenia, and a few years later, was approved for short-term treatment of adults with manic episodes associated with bipolar disorder, become such a HUGE selling medicine? “Despite its extremely limited original approved uses, Zyprexa has gone on to become the top selling antipsychotic worldwide with an estimated 20 million people having used the drug and Lilly’s best-selling product, with $4.2 billion in sales in 2005, which translates into 30% of its total revenues.” This from Furious Seasons: Late last we... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=1646011 Wed, 23 Jul 2008 10:00:58 +0100 1646011 http://www.medworm.com/index.php?rid=1642695&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2008%2F07%2F21%2Fseroxat-suicide-of-course-not-says-glaxo%2F Today, July 21, would have been Sara Carlin’s 20th birthday… Instead, on Sunday, May 6, 2007, Sara, suffering from the side effects of a powerful anti-depressive drug, grabbed a piece of electrical wiring, fashioned a crude noose and hanged herself in the basement of her parent’s house. “We thought this has to be murder. This girl would never do that,” said Neil, her father. “How could someone so beautiful and brilliant, who had so much going for her want to end her life?” Sara had been prescribed Seroxat/Paxil and it changed the person she was. The full story is here. What follows is from Bob Fiddaman. I couldn’t put it any better: I could never even begin to imagine what it would feel like to lose one of my children, in fact the mere though... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=1642695 Mon, 21 Jul 2008 15:17:29 +0100 1642695 http://www.medworm.com/index.php?rid=1640291&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2008%2F07%2F21%2Fseroxat-comics-back-by-popular-demand-but-whats-happened-to-pharma-giles%2F So farewell then Pharma Giles… does anone know what has happened to the excellent (and oh so funny) Pharma Giles blog? Was Giles paid off?  Was he threatened?  Why no explanation? Maybe the answer lies over at Pharma Gossip? Anyway, as it seems that Big Pharma doesn’t like being made fun of, here are the Seroxat comics once again! Although the wonderous ego that is JP Garnier has left Glaxo now, I for one will never forget the caring, sensitive man who watched as Glaxo’s share fell by 40% during his leadership. And what about the MHRA investigation that this year found Glaxo had withheld evidence that the controversial drug, Seroxat, increased the likelihood of suicide among teenagers? Way to go, JP… Comic 1 Comic 2 Comic 3 I’m not sure which one I like best ... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=1640291 Mon, 21 Jul 2008 09:52:49 +0100 1640291 http://www.medworm.com/index.php?rid=1631114&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2008%2F07%2F16%2Fpressure-builds-on-marty-keller-as-grassley-senate-finance-committee-probe%2F I’ve written a lot about Key Opinion Leader Marty Keller in the past… this link takes you to collected posts and downloads. But enough of the past - the pressure is building NOW on Marty Keller and Brown University. This from Pharmalot: Among the 30 or so physicians at two dozen universities that the Senate Finance Committee is probing concerning disclosure of grants from drugmakers is Martin Keller, a psychiatrist at Brown University who is a controversial figure for his role in studying Glaxo’s Paxil antidepressant. The committee, according to sources familiar with the investigation, sent a letter to Brown as part of its investigation. We are awaiting a reply from Brown and will update you shortly. In recent weeks, the committee has acknowledged focusing on three academic p... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=1631114 Wed, 16 Jul 2008 10:31:30 +0100 1631114 http://www.medworm.com/index.php?rid=1603077&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2008%2F07%2F10%2Fopen-letter-to-paul-blackburn-glaxosmithkline%2F I understand that Ofsted recently asked you to resign from your post as a non executive member of their Board (just days after you were appointed). [Interested readers can see an excellent article about this story from Eileen Fairweather of the Daily Mail here.] Said Ofsted “…His [Paul Blackburn] resignation follows public concerns about the activities of his employer GSK. Paul did not want any negative press interest to detract from the excellent work of Ofsted and therefore resigned.” You said “At Ofsted’s request, I have resigned… I wish to make it clear that this decision should in no way give credibility to the spurious allegations which have been reported regarding GlaxoSmithKline. These are entirely without foundation and have been previously addressed by... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=1603077 Thu, 10 Jul 2008 09:52:55 +0100 1603077 http://www.medworm.com/index.php?rid=1593873&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2008%2F07%2F08%2Fheart-attacks-and-suicides-yet-the-dangers-were-all-kept-so-quiet-so-how-can-you-trust-your-medicine%2F Thanks to Truthman30 for this from today’s Dail Mail by Jerome Burne: Few of us would think to question the safety of our prescription drugs. After all, they’ve been developed to make us better. But just how safe are they really — and is the official drug watchdog doing enough to protect us? Last month, for instance, it was revealed that the number of powerful anti-psychotic drugs being prescribed to children had almost doubled in past six years. Yet despite the growing evidence that these drugs can seriously harm children — causing excessive weight gain, a rise in blood pressure, severe lethargy and even lactation — the Medicines and Healthcare Products Regulatory Agency is powerless to limit their use. The problem is that these drugs aren’t officially licensed for use on ... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=1593873 Tue, 08 Jul 2008 06:52:20 +0100 1593873 http://www.medworm.com/index.php?rid=1535779&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2008%2F06%2F21%2Ffda-didnt-get-paxilseroxat-risk-documents%2F From Furious Seasons: This is just up on the excellent WSJ Health Blog. The news is that the FDA got left out of some of the documents around suicidality data on Paxil. From the paper’s Alicia Mundy: “Here’s how things went down. Plaintiffs attorneys in Los Angeles got permission last year from Glaxo’s defense team to give the Justice Department (at DOJ’s request) access to a ton of confidential material, including the right to discuss details about it all with the plaintiffs lawyers. Glaxo had insisted previously on having them sealed in Federal Court. “Several months later, when the plaintiffs lawyers at Baum Hedlund asked for permission to give the same stuff to the FDA, Glaxo’s defense team balked. “On Oct. 15, 2007, Glaxo’s outside lawyers at King and... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=1535779 Sat, 21 Jun 2008 10:38:36 +0100 1535779 http://www.medworm.com/index.php?rid=1535780&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2008%2F06%2F21%2Fus-investigation-into-glaxo-and-paxilseroxat-widens%2F This just in from Pharmalot: A Justice Department investigation of Glaxo’s handling of the marketing and safety research of its antidepressant, appears to be widening, The Wall Street Journal reports. The drugmaker confirmed that a previously disclosed Colorado-based Justice Department investigation of marketing practices also includes the US Attorney’s office in Boston and is being coordinated by the agency in Washington. At a meeting convened in Boston by an agency prosecutor last year, plaintiffs’ lawyers representing families suing Glaxo say they were asked about info, documents and depositions concerning Paxil’s potential link to suicidal behavior in adolescents and adults, and how the company portrayed that risk to doctors and the FDA, the Journal writes. This follows a recen... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=1535780 Sat, 21 Jun 2008 10:32:57 +0100 1535780 http://www.medworm.com/index.php?rid=1526259&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2008%2F06%2F18%2Fglaxo-marketing-strategy-under-threat-from-the-fda%2F What I find most amazing about this story is this quote from Christopher Viehbacher, president of North American pharmaceuticals for Glaxo. Says Viehbacher “…it is harder to get approval for variations of drugs because the FDA now demands to know why they are better than the original.” Well excuse me, Chris - what do think the FDA should do? A well known tactic that companies like Glaxo undertake in order to maximise revenue from best selling drugs about to go out of patent is this: they simply create a slightly different version of the drug and start to market the ‘new, improved’ version. Maybe it’s simply a slow release version, or maybe it has a few different molecules. Whatever, the important thing is that it must be able to be patented once again. A... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=1526259 Wed, 18 Jun 2008 20:50:54 +0100 1526259 http://www.medworm.com/index.php?rid=1526260&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2008%2F06%2F17%2Fmore-on-paxil-and-suicide-glaxo-was-aware-of-this-risk-and-hid-it%2F This from the Wall Street Journal By ALICIA MUNDY and JEANNE WHALEN (with thanks to Truthman30): Unsealed Report Claims Suicide Risk Was Miscalculated WASHINGTON — GlaxoSmithKline PLC faces new questions about whether it deliberately misrepresented data on suicide risk for its antidepressant Paxil when it applied for the drug’s approval to the U.S. Food and Drug Administration at an advisory committee meeting in 1991, a charge the company has denied. A study by a Harvard psychiatry instructor, underwritten by plaintiffs’ lawyers and previously kept under seal by a court order, says that Glaxo “improperly” counted patients taking placebos during clinical studies. From 1989 through 1991, Glaxo then submitted information to the FDA that indicated no major differe... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=1526260 Tue, 17 Jun 2008 06:43:48 +0100 1526260 http://www.medworm.com/index.php?rid=1522177&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2008%2F06%2F16%2Fmissing-report-pages-seen-for-the-first-time-proof-that-glaxo-hid-paxil-risk%2F This from Pharmalot: Last week, US Senator Chuck Grassley called for a probe into Glaxo and the FDA over their handling of the Paxil antidepressant. At issue are the long-standing allegations that the drugmaker knew about suicide risks in children for nearly 15 years but obscured evidence. In demanding the probe, Grassley cited a report prepared by Joseph Glenmullen, a Harvard psychiatry professor, for litigation in federal court in California over Paxil side effects. The report was unsealed earlier this year, but was missing some pages. Last week, those pages became available and include a section that describes in some detail how Glaxo allegedly manipulated so-called placebo suicides. These are deaths that occur among patients who are taken off other meds so they can participate in a tri... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=1522177 Mon, 16 Jun 2008 13:11:51 +0100 1522177 http://www.medworm.com/index.php?rid=1516562&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2008%2F06%2F13%2Fus-senator-seeks-fda-probe-of-glaxos-paxil-data-was-safety-information-withheld-in-the-usa%2F U.S. Sen. Charles Grassley asked U.S. regulators on Thursday to investigate whether drugmaker GlaxoSmithKline Plc withheld data about a risk of suicide linked to its anxiety disorder drug Paxil. Grassley, a Republican from Iowa, said in a letter that a British regulatory agency had found Glaxo knew Paxil was associated with a higher risk of suicidal behavior in adolescents as far back as 1998. “I would like you to take a look at the information that agency gathered and determine if the company has withheld safety information here as well,” Grassley wrote in the letter to the heads of the U.S. Department of Health and Human Services and the Food and Drug Administration. Grassley also asked the FDA to review a report by a Harvard psychiatrist who has submitted information as par... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=1516562 Fri, 13 Jun 2008 05:31:06 +0100 1516562 http://www.medworm.com/index.php?rid=1494370&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2008%2F06%2F04%2Fpaxil-study-329-lest-we-forget%2F Thanks to Healthy Skepticism and Pharmagossip for this: GlaxoSmithKline’s Study 329 of medication for adolescent depression failed to demonstrate any benefit for paroxetine over placebo in adolescents and demonstrated a worrying profile of adverse events for paroxetine. The study was ultimately published in 2001 by the Journal of the American Academy of Child and Adolescent Psychiatry with Keller as the primary author. This misleading paper has been a focus of interest for Healthy Skepticism since 2002. In 2003 they wrote to the Editor of JAACAP raising concerns about the misleading reporting by the authors that exaggerated benefit and downplayed adverse effects. (They also questioned editorial functioning, which drew an angry response from the Editor). In 2004 CMAJ published an Editoria... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=1494370 Wed, 04 Jun 2008 21:20:24 +0100 1494370 http://www.medworm.com/index.php?rid=1395137&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2008%2F04%2F24%2Fglaxo-refuse-to-co-operate-with-the-mhra-once-again%2F At the end of the recent 4 year long investigation into Glaxo by the MHRA (the probe began after disclosure that Glaxo withheld data from Seroxat clinical trials), Kent Woods (CEO of the UK’s medicines regulator the MHRA) wrote to JP Garnier at GlaxoS mithKline - a small section of the letter read: “You will be aware that we have reviewed a large quantity of documents from GSK. Legal provisions prevent us from releasing publicly any information gained under our statutory powers in the course of a criminal investigation. However, there has been a significant level of quite legitimate public interest in this case, and I would there like to release that information into the public domain. This of course requires your consent. GSK has regularly asserted that it has nothing to hide ... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=1395137 Thu, 24 Apr 2008 08:44:10 +0100 1395137 http://www.medworm.com/index.php?rid=1380544&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2008%2F04%2F17%2Fmhra-staff-co-operate-with-glaxo-to-monitor-the-internet%2F My last post bemoaned the fact after during the recent 4 year long investigation into Glaxo by the MHRA (the probe began after disclosure that Glaxo withheld data from Seroxat clinical trials), it was announced by the MHRA that Glaxo and individual Glaxo employees declined “invitations to attend interviews…” Glaxo employees simply decided not to co-operate with the criminal investigation into their actions and said they would not answer questions. However, in an ironic twist we now have evidence that Glaxo, the MHRA and Glaxo’s lawyers, are happy to work together to monitor the internet, in particular Bob Fiddaman, who has noticed some interesting recent visitors to his blog (Seroxat Sufferers). Now, I’ve always said the MHRA and Glaxo were too close by half, but it s... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=1380544 Thu, 17 Apr 2008 20:40:19 +0100 1380544 http://www.medworm.com/index.php?rid=1119276&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F12%2F27%2Fthe-chemical-imbalance-theory-come-on-glaxo-prove-it-now%2F When I started taking Seroxat in 1997, I wanted to know how this great new drug worked - the PIL (the leaflet that came with the tablets told me)“it boosts the levels of serotonin in your brain and that’s what makes you stop feeling depressed” I was told. It’s a simple chemical imbalance said the PIL. By 2003, GSK said in it “Seroxat is one of a group of medicines called selective serotonin reuptake inhibitors (SSRIs) and works by bringing the levels of serotonin back to normal.” All lies. The chemical imbalance ‘theory’ HAS NEVER BEEN PROVED. NEVER. Finally by mid 2006 GSK was starting to get closer to admitting the truth in its PIL “It is not fully understood how Seroxat and other SSRIs work…” At least that’s what they tell us in the UK and USA... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=1119276 Thu, 27 Dec 2007 16:02:23 +0100 1119276 http://www.medworm.com/index.php?rid=1114446&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F12%2F24%2Fseroxat-comics-once-again%2F Happy Xmas everyone - enjoy the comics: Comic 1 Comic 2 Comic 3 I’m not sure which one I like best - it’s maybe a bit unfair to pick on poor Alastair Benbow quite so much because Breckenridge was just as useless when he was interviewed on Panorama. OK - I’m sorry, I’ve had a chance to reconsider that last remark - I take it back. Pick on Benbow as much as you like, he deserves it! You’ll remember that Benbow is the man, who, when asked on television by pharmacology expert Dr Andrew Herxheimer about why GSK had given no warning about the severe reactions from Seroxat despite knowing about it for 5 years… simply replied “Seroxat has provided countless benefits to many people and enabled them to do more, live longer and feel better… and I think that spea... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=1114446 Mon, 24 Dec 2007 13:44:26 +0100 1114446 http://www.medworm.com/index.php?rid=1104355&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F12%2F19%2Fimportant-new-paxil-withdrawal-documentary-finally-completed%2F Phil Lawrence, the film maker who filmed his withdrawal from Paxil (Seroxat) has just posted a trailer for his movie on the internet - thanks are due to Truthman30 for letting me know:Phil summed things up really well a while back:“I’m starting to think that antidepressants are like the ‘perfect storm’ – everything came together to create the ultimate moneymaker. You’ve got the perfect consumers – people who desperately want and need help. You’ve got the perfect illness – one that cannot be scientifically proven and is subjectively diagnosed. You’ve got the perfect marketing scheme – huge advertising campaigns in magazines and on television that play directly on the consumer’s fears and desires to get better. And, you’ve got the perfect pushers – government regu... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=1104355 Wed, 19 Dec 2007 08:03:52 +0100 1104355 http://www.medworm.com/index.php?rid=1047588&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F11%2F23%2Fan-insider-explains-why-glaxo-bought-reliant-pharma%2F More from Cafe Pharma here. The inside track? “Talked with a home office insider he said that the main reason they went after Reliant is to postpone layoffs until the fall of 2009 when we lose a ton of patents. They want to squeeze every dollar out of the portfolio and keep the reps focused for the next 2 years. Just be prepared for late 2009, if nothing new gets approved it will all hit the fan.” and another sales rep comments: “Hey idiots - Lovaza is only indicated for patients with TGs greater than 500. How many patients actually fit this description? approx 5-15% of the cholesterol market, so any doc RXing it for tgs below 500 is ‘going off label’ (which is their right). The problem you will face at GSK is that your reps have the high power microscope of t... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=1047588 Fri, 23 Nov 2007 22:25:04 +0100 1047588 http://www.medworm.com/index.php?rid=1034306&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F11%2F17%2Fsufferers-sue-happy-pill-firm-for-30million%2F This from the Daily Mail: Pharmaceutical giant Glaxo-SmithKline is facing a £30million damages claim from users of its anti-depressant Seroxat.Lawyers representing patients who insist the bestselling drug is addictive have issued the first of 600 High Court writs against the company, each seeking compensation of up to £50,000. Since first prescribed in Britain in 1990, Seroxat has been linked to at least 50 suicides of adults and children.GSK, which makes up to £1billion a year from the drug, is already embroiled in lawsuits with American users, and has been accused of failing to act on warnings that it could have serious side-effects, including mood swings and personality changes. Mark Harvey, of law firm Hugh James, claims Seroxat is “defective” under the 1987 Consumer Pro... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=1034306 Sat, 17 Nov 2007 22:49:07 +0100 1034306 http://www.medworm.com/index.php?rid=1027122&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F11%2F14%2Fgsk-and-its-approach-to-litigation-in-canada%2F This is a post from Paxil Progress: GSK has met with, and settled with many children who suffered side effects from paxil. The legal system in Canada stinks, and the lawyers won’t go up against the pharmaceuticals here. I know, I phoned every firm. I obtained a high profile US lawyer. He is a wonderful man, one who is aware of the extent of suffering the children go through. Last November (2006) was a very difficult month for my daughter. She had to meet with a GSK lawyer and discuss what she went through due to paxil. Before meeting with their lawyer we had a coffee with our US lawyer. My daughter does not like to discuss her paxil experience with anyone. She spoke with him openly, because she ‘knew’ he truly understood. She spoke about waking up each morning, her first thought bein... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=1027122 Wed, 14 Nov 2007 22:24:00 +0100 1027122 http://www.medworm.com/index.php?rid=1001016&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F11%2F02%2Fadvantages-of-paroxetine-for-depression-anxiety%2F Whoa there, CL Psych’s gone to town on this one… Someone has written to him asking about the Advantages of Paroxetine for depression & anxiety. No really. I reproduce just a part of his reply below: Please see the following posts for a detailed explanation of the “advantages” of paroxetine (Paxil/Seroxat) as discussed previously on my site… Advantage 1: Increases suicide attempts in patients. Advantage 2: Potentially increases obesity in patients, though research is preliminary. Advantage 3: Increase in birth defects for children whose mothers were taking Paxil while pregnant. Advantage 4: Excellent marketing, both for social phobia and depression. Excellent use of misleading writing in so-called scientific journals when writing about the “advant... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=1001016 Fri, 02 Nov 2007 22:31:42 +0100 1001016 http://www.medworm.com/index.php?rid=1001017&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F11%2F02%2Fan-honest-insider-post-the-real-future-at-gsk%2F This from Cafepharma, my thanks to Truthman30 for the tip-off - the entire thread is here. I have had access to executive level discussions regarding the GSK layoffs. I am posting this information from an anonymous “business center” computer location. I won’t say anymore, except that my credibility is legitimate. I understand that rumor, speculation, and misinformation is running rampant right now through out the entire GSK organization. I feel that the lack of communication with our sales force regarding the true intentions of this company is regrettable. I personally know quite a few of the excellent employees of GSK that will be terminated. I am dismayed that executive level management has so little regard for the employees welfare. Yes, I remember the Zantac Hawaii tr... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=1001017 Fri, 02 Nov 2007 22:10:36 +0100 1001017 http://www.medworm.com/index.php?rid=977430&cid=t_113167_150_f&fid=35777&url=http%3A%2F%2Ffeeds.feedburner.com%2F%7Er%2FPharmalot%2F%7E3%2F174809461%2F C is for contraction. C is also for convulsion. Both describe what pharma is experiencing these days. And the number of jobs being cut makes it all too clear. The trend - whether one calls it layoffs, restructuring, downsizing or reorganization - was under way a few years ago, of course. Merck began eliminating thousands of jobs a few years ago. Wyeth also began trimming a while back. But 2007 has been particularly severe for the industry. Here’s a handy list then from Fierce Biotech, which did the simple math for a Top 5 list. But we chose to add a couple of the more recent cutbacks, just to provide further contest. Have we forgotten anyone? Please tell us: 1. Pfizer - 10,000 jobs 2. AstraZeneca - 7,600 jobs 3. Bayer - 6,100 jobs 4. Johnson & Johnson - 5,000 jobs 5. Amgen - 2,6... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=977430 Thu, 25 Oct 2007 12:01:25 +0100 977430 http://www.medworm.com/index.php?rid=958987&cid=t_113167_150_f&fid=35777&url=http%3A%2F%2Ffeeds.feedburner.com%2F%7Er%2FPharmalot%2F%7E3%2F171335243%2F The sky has turned dark, which is a signal that the time has come to tend to other matters, such as helping the short people with homework. Those of you without homework will, hopefully, enjoy the evening. Here are a few items, meanwhile, that you may have missed… Boston Scientific To Cut 2,300 Jobs (Yahoo/Reuters) Glaxo Files A Temporary Injunction Against US Patent Office (IPWatchdog.com) Pfizer Reports Earnings Tomorrow Amid A Gloomy Outlook (Bloomberg News) Arena Pharmaceuticals Reports A Wider Loss (Yahoo/AP) IMS Health Profit Declines In Recent Quarter (Yahoo/Reuters) US Is Dragging Its Heels On Biosimilars: Report (BioPharmaReporter.com) Share / E-mail (Source: Pharmalot) Pharmalot blogs http://www.medworm.com/rss/comments.php?id=958987 Wed, 17 Oct 2007 23:08:36 +0100 958987 http://www.medworm.com/index.php?rid=935274&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F10%2F08%2Fuk-pension-fund-to-lead-fraud-fight-against-glaxo%2F A regional UK pension fund has been appointed to spearhead a US class-action lawsuit against GlaxoSmithKline (GSK), accusing the pharmaceutical giant of misleading the market over its controversial diabetes pill Avandia. Avon Pension Fund, which manages about £1 billion on behalf of public sector workers, was appointed “lead plaintiff” — a US term for the institution fronting a group lawsuit on behalf of other investors — over the weekend. Although both private and public pension funds in the UK are showing an increasing interest in US class-action lawsuits, it is rare for them to take such a prominent role. In the GSK lawsuit — which accuses the group of “fraud” and “deceit” by withholding information about the risks of Avandia — Avon was competing with the North York... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=935274 Mon, 08 Oct 2007 20:58:51 +0100 935274 http://www.medworm.com/index.php?rid=870435&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F09%2F14%2Fuk-pension-funds-vie-to-lead-court-action-over-gsk-drug%2F I wonder if JP Garnier has seen the Times this morning? Two UK pension funds are vying to lead a US class action lawsuit against GlaxoSmithKline (GSK), accusing the pharmaceutical giant of misleading the market over its controversial diabetes pill Avandia. North Yorkshire Pension Fund and Avon Pension Fund, local government schemes that together manage more than £3 billion in assets, have both applied to be lead plaintiff in the case – a US term for the institution fronting a lawsuit on behalf of other investors. While UK funds frequently join US class action lawsuits as minor players, it is highly unusual for them to seek such a prominent role. The funds have jointly appointed Coughlin, Stoia, Geller, Rudman and Robbins, a New York law firm, to represent them. The two UK funds are unde... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=870435 Fri, 14 Sep 2007 05:45:12 +0100 870435 http://www.medworm.com/index.php?rid=869542&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F09%2F13%2Fglaxosmithkline-hid-the-risks-of-its-avandia-diabetes-drug%2F …to protect more than $2 billion in annual sales, according to a lawsuit filed by a lawyer who has won multimillion-dollar verdicts against other drugmakers. Officials at Glaxo, Europe’s biggest drugmaker, knew research showed Avandia users faced an increased risk of heart attack and failed to warn them, attorney Mark Lanier said in the suit filed Sept. 7 in federal court in New York. Lanier, who won a $253 million verdict against Merck & Co. over its withdrawn Vioxx painkiller, sued Glaxo on behalf of Avandia user Frank Curley. Curley suffered a heart attack in 2004. “Avandia poses significant safety risks due to defects in its design and inadequate labeling,” Lanier said in the suit, which is seeking more than $100 million in damages. Full story here at Bloomb... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=869542 Thu, 13 Sep 2007 20:01:25 +0100 869542 http://www.medworm.com/index.php?rid=863747&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F09%2F11%2Fwhat-does-seroxat-do-and-just-how-is-it-supposed-to-work%2F I’m sorry - run that by me again will you Glaxo…? When I started taking Seroxat in 1997, I wanted to know how this great new drug worked - it boosts the levels of serotonin in your brain and that’s what makes you stop feeling depressed I was told. It’s a simple chemical imbalance - and the leaflet that came with the tablets told me “Remember you can’t become addicted to Seroxat.” In 2002 the Patient Information Leaflet (PIL) still told us “these tablets are not addictive”, and that withdrawal problems “are not common and not a sign of addiction”. “Remember you can’t become addicted to Seroxat.” had been dropped completely from the Patient Information Leaflet (PIL) by 2003 when GSK said in it “Seroxat is one of a group of medicines called selective sero... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=863747 Tue, 11 Sep 2007 20:47:58 +0100 863747 http://www.medworm.com/index.php?rid=836875&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F09%2F02%2Fglaxo-the-status-quo-is-no-longer-an-option-its-no-good-producing-more-of-the-same%2F “I’ll be a hero in three years” JP Garnier 5 April 2004 Sorry JP, but I think you’re past your sell by date. This from today’s Observer: GlaxoSmithKline, the UK drugs giant, faces a shareholder revolt over its dismal share price performance. Anger has spilt into discussions between investors and chairman Sir Christopher Gent over who should succeed chief executive Jean-Pierre Garnier. He is due to retire in May 2008.GSK’s big institutional shareholders have held meetings with Gent and told him in no uncertain terms that Garnier’s successor should be someone who is prepared to undertake a fundamental overhaul of the company and consider a radical streamlining of its operations, including a possible break-up. One institutional investor says: ‘What we are t... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=836875 Sun, 02 Sep 2007 18:12:43 +0100 836875 http://www.medworm.com/index.php?rid=830003&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F08%2F29%2Fharrington-investments-divests-from-glaxosmithkline%2F August 29, 2007 Contact: Jack Ucciferri (707) 257-7923 Fax (707) 252-6166 Voice www.harringtoninvestments.com Harrington Investments Divests From GlaxoSmithKline Cites Litany of Concerns Napa, CA - Harrington Investments, Inc. (HII), a socially responsible investment (SRI) advisory firm, announced today that it has divested from GlaxoSmithKline (GSK) stock. “In accordance with our long term investment management style, we would prefer to remain invested in GSK,” said John Harrington, President and CEO of Harrington Investments. “However, we have a fiduciary duty to our clients that includes a comprehensive review of a corporation’s overall operations and reputation.” In a letter to GlaxoSmithKline CEO, Jean-Pierre Garnier, Harrington listed six points of concern with the company,... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=830003 Wed, 29 Aug 2007 22:28:25 +0100 830003 http://www.medworm.com/index.php?rid=829968&cid=t_113167_87_f&fid=34867&url=http%3A%2F%2Fwww.thediabetesblog.com%2F2007%2F08%2F29%2Fglaxo-touts-diabetes-wellness-plan-for-employees%2F Filed under: Lifestyle, Services, Support, CarePharmaceutical giant GlaxoSmithKline has announced an initiative designed to improve the health of employees with diabetes. Yes, the company's head honchos decided they would take the bull by the horns: if employees have difficulty taking care of their health, they determined to find out why and correct the problem. Result: an internal analysis of healthcare spending within GSK.Turns out diabetes was one of the biggest problems for Glaxo employees. Glaxo's number-crunchers found the company spends more on diabetes medications, but less on medical care, than the national average. GSK's report states the company spent a total of $26.2 million on diabetes treatment for employees in 2005. Glaxo has now launched what it describes as a multilateral ... The Diabetes Blog blogs http://www.medworm.com/rss/comments.php?id=829968 Wed, 29 Aug 2007 04:00:00 +0100 829968 http://www.medworm.com/index.php?rid=828151&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F08%2F28%2Fchallenges-persist-for-jp-garnier-at-glaxo%2F A string of high-profile setbacks isn’t what Jean-Pierre Garnier envisioned as he enters the home stretch as CEO of GlaxoSmithKline, writes Robert Steyer at TheStreet.com Back in 2006, he agreed to delay his retirement until May 2008, instead of October 2007, so he could shepherd the launch of new drugs with alluring revenue prospects. Instead, Garnier is spending much of his time defending the diabetes drug Avandia, coping with regulatory and scientific delays for two touted compounds and supervising a giant stock repurchase due to Glaxo’s slumbering shares. “Diversity is Glaxo’s biggest strength,” says Heather Brilliant of the independent research firm Morningstar. “Clearly, Avandia will be an overhang for awhile. But Glaxo can withstand the bumps that... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=828151 Tue, 28 Aug 2007 20:38:53 +0100 828151 http://www.medworm.com/index.php?rid=823598&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F08%2F27%2Fdrug-companies-manipulate-legal-system-to-deny-justice-to-patients%2F New York Times 21 August 2007 Merck’s Vioxx Defence Strategy Prevents Plaintiffs From Getting Compensation: The case of Vioxx litigations demonstrates that consumers of inadequately tested FDA-approved medicines that prove lethal, are no better off than in the pre-FDA snake-oil era. The New York Times reports that despite Merck’s withdrawal of Vioxx from the market due to its causing cardiovascular damage, Merck’s legal defense strategy is working: The strategy’s successes, from the view of Merck and its shareholders, are clear: “In fact, none of the 45,000 people who have sued Merck, contending that they or their loved ones suffered heart attacks or strokes after taking Vioxx, have received payments from the company. The lawsuits continue, for now in a state ... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=823598 Mon, 27 Aug 2007 10:50:06 +0100 823598 http://www.medworm.com/index.php?rid=819548&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F08%2F24%2Fjp-garnier-and-his-new-flu-vaccine-plans-just-another-%25e2%2580%2598stupid-investment%25e2%2580%2599%2F You’ve got to wonder about JP and his stewardship of Glaxo. Just when he must have been happy to tie up some bird flu vaccine deals, we learn things may not be so straightforward. This from Ed Silverman at Pharmalot: Have Glaxo and Novartis stumbled yet again? That’s the question raised in a look at Protein Sciences, a much smaller company using a DNA technology to develop flu vaccines that may prove faster than the methods being used by its much bigger rivals, Bloomberg News reports. Losing the flu-shot race may be the latest in a series of setbacks for both drugmakers, which are building plants that are part of a $1 billion US initiative to produce millions of inoculations within six months of an outbreak of a deadly flu. But Protein Sciences, with just 40 employees, is close to... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=819548 Fri, 24 Aug 2007 07:53:01 +0100 819548 http://www.medworm.com/index.php?rid=812276&cid=t_113167_150_f&fid=35777&url=http%3A%2F%2Ffeeds.feedburner.com%2F%7Er%2FPharmalot%2F%7E3%2F146492390%2F Who is this flying nun? Sally Fields, of course. That was a hit 1960’s TV series in which she starred as an innocent waif with the equivalent of wings. More recently, though, the perky actress with the youthful look - she’s 60 years old now - has successfully pitched a campaign for Boniva, the osteoporosis med marketed by Roche and Glaxo. Last week, however, Novartis won FDA approval for a rival med, Reclast, which only needs to be taken once a year. But as Joe Tooley, an analyst at AG Edwards points out in an investor note this morning, the market is flat - year-over-year growth is only 0.3 percent. Right now, the leader is Merck’s Fosamax, with a 41.5 percent share of the oral bisphosphonates market. But, he notes, “perhaps the biggest challenge to Reclast’s acc... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=812276 Tue, 21 Aug 2007 12:45:25 +0100 812276 http://www.medworm.com/index.php?rid=809613&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F08%2F20%2Fseroxat-prescribing-infomation-updated-in-the-uk%2F Well, it had to happen… Glaxo have updated the prescribing information for Seroxat. Not the PIL that is supplied with the drug, but the detailed prescribing information that can be found here. My thanks to Truthman30 for alerting me to this. We will have to wait to see if the PIL changes at all (and when) - but surely it must change to reflect this major revision to the prescribing information (but it’s still too little too late). One question for Glaxo - why are tablets not available in 5mg and 2.5mg strengths - to take this simple step would help all the patients who suffer from withdrawal symptoms when trying to stop taking the drug. Two sections of the revised document are of particular interest - Special warnings and precautions for use and Undesirable effects - read them ... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=809613 Mon, 20 Aug 2007 10:11:49 +0100 809613 http://www.medworm.com/index.php?rid=801403&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F08%2F15%2Fglaxo-drug-makes-you-hypersexual-and-a-compulsive-gambler%2F   This from BrandweekNRX: On August 4 GlaxoSmithKline was forced to update its package insert for Requip, a drug used to treat restless legs syndrome (RLS) or, “jitters in the legs,” which some claim isn’t a real disease. What is real, is that Requip also causes “pathological gambling,” and “increased libido including hypersexuality.” We know this because that’s what the new package insert says. And we found out because Laura Strickler, Producer of CBS Evening News, kindly wrote us and tipped us off to this story. The GlaxoSmithKline package insert for Requip claims these unusual side-effects are a class effect, and says, “Impulse control symptoms, including compulsive behaviors such as pathological gambling and hypersexuality, have been reported in patients ... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=801403 Wed, 15 Aug 2007 20:01:11 +0100 801403 http://www.medworm.com/index.php?rid=801405&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F08%2F15%2Fglaxosmithklines-avandia-is-required-to-carry-the-most-serious-type-of-labelling-telling-patients-of-its-link-to-heart-failure%2F This from today’s Times: US regulators have approved new “black box” warning labels for GlaxoSmithKline’s controversial diabetes drug Avandia. The warnings, the strictest that prescription drugs can bear in the US, emphasise the drug may trigger heart failure and that patients should be monitored closely by their physicians. The decision from the US Food and Drug Administration (FDA) follows a recommendation from an FDA advisory committee last month that proposed Avandia and Actos, another diabetes drug manufactured by Japan’s Takeda, should both carry the warnings. GSK has agreed to comply with the black box order, which means that Avandia will carry a boxed warning with greater prominence than its existing notification. However, the FDA will continue to review the risk... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=801405 Wed, 15 Aug 2007 13:35:59 +0100 801405 http://www.medworm.com/index.php?rid=790579&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F08%2F09%2Fearth-to-garnier-come-in-jp%2F What planet are you JP? I mean really - when I read your Economist interview I had to laugh… you really are in your own little world aren’t you. Things are not good at Glaxo. That share price really should be much, much higher - especially given what you think you’re worth! I read: Another reason Mr Garnier is smiling is that GSK has the strongest drugs pipeline of any big firm. It has 33 drugs in the late stage of clinical trials, with perhaps two dozen due to be launched between now and the end of 2009. That is much better than at rival firms, and far better than the pitiful prospects Mr Garnier inherited when he took over as boss of SmithKline Beecham in 2000, just before the merger with Glaxo Wellcome. The industry’s poor research output has led some critics to ... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=790579 Thu, 09 Aug 2007 13:19:01 +0100 790579 http://www.medworm.com/index.php?rid=789215&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F08%2F09%2Fgsk-jp-garnier-seroxat-avandia%2F Looks like Crystal Dove has been at it again - there’s a new video on YouTube entitled “GSK-JP Garnier-Seroxat-Avandia” I wonder what’s it about…..? I’ll leave you to watch it and find out. (Source: seroxat secrets...) seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=789215 Thu, 09 Aug 2007 12:43:09 +0100 789215 http://www.medworm.com/index.php?rid=786737&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F08%2F08%2Fglaxosmithkline-lessons-of-a-failed-merger%2F Truthman30 has been busy again. He unearthed this little gem from 2002, written by Matthew Lynn from Bloomberg. I think it’s worth reading because of my previous post about JP (Garnier) and his failure to deliver a decent share price to Glaxo’s investors. JP’s problem is that he’s just too greedy and too arrogant - this from 2002 “If Garnier were producing results, fewer people might gag at a raise on top of the highest salary in the land. The trouble is, he isn’t. GSK’s shares have been dismal performers. Compared with a peak in 2000 of £21 pounds, they now stand at just over £12″. Today’s share price is just over £13 that’s only because JP committed Glaxo to more than double its share buyback programme to £12 billion . This ... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=786737 Wed, 08 Aug 2007 08:22:45 +0100 786737 http://www.medworm.com/index.php?rid=783921&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F08%2F07%2Fwhat-does-jp-garnier-know-that-we-dont%2F Trthman30 has just alerted me to interesting news about your friend and mine, JP Garnier the CEO of Glaxo. It seems his share options have been exercised and sold on straight away. His actions are being discussed on investment sites around the world such as this one. “I see from the news tab that Garnier has just exercised a goodly chunk of options and sold every last one of them, netting himself just under £6,000,000 in the process. That doesn’t send a very encouraging signal to shareholders who would like to see these bigshots’ legs held firmly to the fire. Makes you wonder what Garnier thinks about GSK? Well, for sure, one thing he thinks is that, given an influx of almost 6 million ackers he’s got something better to do with the wonga than keep it in GSK share... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=783921 Tue, 07 Aug 2007 13:27:55 +0100 783921 http://www.medworm.com/index.php?rid=782979&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F08%2F06%2Fdoctoring-the-evidence-glaxosmithkline-pushes-depression-drug%2F Here’s the link to an article (written by investigative journalist Shelley Jofre) outlining the story of Glaxo and its infamous Study 329: “UK-based GlaxoSmithKline (GSK), the second largest drug company in the world, which recorded 2006 sales of over $45 billion, had begun a series of clinical trials in the mid-1990s to test whether paroxetine would work in depressed children. Paroxetine had already been hailed as a wonder drug in adults as a treatment for everything from depression and stress to anxiety and even shyness. By the new millennium 100 million paroxetine prescriptions had been written worldwide, bringing in $2 billion a year for GSK and placing the antidepressant a close second to Prozac in popularity. With the adult market sewn up, the company sought new ways to m... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=782979 Mon, 06 Aug 2007 15:12:05 +0100 782979 http://www.medworm.com/index.php?rid=782980&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F08%2F06%2Fsuch-sad-news-in-loving-memory%2F I’ve been away in Spain for a while and it was a shock to come back to the news from Paxil Progress of a Seroxat suicide. Scotty (Paxil Progress administrator) wrote: “We have had a tragedy in our paxilprogress family. The post below is from David Singletary, a friend and roomate of criss. From his report, criss took his own life last night. We know the pain and despair he was in from his posting here. I think we can take some comfort in the fact that he found us and had contact with others in paxil withdrawal. Sadly, it took his life. May he find the peace he so deserved and may his friends and family know that in our short time that we knew him, he touched our hearts. I’ve quoted the initial posting below: this is david singletary, criss had been living with me trying t... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=782980 Mon, 06 Aug 2007 14:49:49 +0100 782980 http://www.medworm.com/index.php?rid=777916&cid=t_113167_150_f&fid=35781&url=http%3A%2F%2Fwww.qdinformation.com%2Fqdisblog%2F2007%2F08%2F03%2Fmergers-acquisitions-and-deals%2F I’m trying to get caught up on a lot of stuff since taking a few days of to visit family and friends. Here are some of the stories recently regarding mergers & acquisitions as well as deals. PharmaLive: SurModics Acquires Brookwood Pharmaceuticals Surmodics is a drug delivery company and Brookwood is also in the same drug delivery area but has experience in long acting injectable drugs. THis seems on the surface to make sense but I’ve not dug into enough to give further opinion. Merck to buy NovaCardia: SignOnSanDiego.com PharmaLive: Merck & Co., Inc. to Acquire NovaCardia, Inc., to Boost Clinical Pipeline of Cardiovascular Drug Candidates Merck wants to add to its cardiovascular drug line and so is acquiring NovaCardia for its lead candidate KW-3902 for treatment of a... QDIS Blog blogs http://www.medworm.com/rss/comments.php?id=777916 Fri, 03 Aug 2007 18:06:16 +0100 777916 http://www.medworm.com/index.php?rid=758685&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F07%2F26%2Fseroxat-comics-reprise%2F When I was young a big part of my summer holiday were the comics I bought. So in the spirit of times past, here are the Seroxat comics yet again: Comic 1 Comic 2 Comic 3 I’m not sure which one I like best - it’s maybe a bit unfair to pick on poor Alastair Benbow quite so much because Breckenridge was just as useless when he was interviewed on Panorama. OK - I’m sorry, I’ve had a chance to reconsider that last remark - I take it back. Pick on Benbow as much as you like, he deserves it! You’ll remember that Benbow is the man, who, when asked on television by pharmacology expert Dr Andrew Herxheimer about why GSK had given no warning about the severe reactions from Seroxat despite knowing about it for 5 years… simply replied “Seroxat has provided countless... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=758685 Thu, 26 Jul 2007 05:42:01 +0100 758685 http://www.medworm.com/index.php?rid=758687&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F07%2F26%2Frecapturing-the-vision%2F Pharmaceutical firms need to make some drastic changes to the way they do business if they are to regain the public’s trust and must be seen to be more interested in medicines than market share to avoid even more damage to their image, a leading industry observer has told PharmaTimes World News. Peter Claude, a USA-based partner at PricewaterhouseCoopers pharmaceutical and life sciences advisory services group, was speaking as the firm published a report, Recapturing the Vision which highlights the significant differences between the public’s view of pharmaceutical companies and the industry’s self perception. Mr Claude said that “it is difficult to comprehend how an industry that has saved so many lives should be held in such low public esteem.” At present, ... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=758687 Thu, 26 Jul 2007 05:37:05 +0100 758687 http://www.medworm.com/index.php?rid=747666&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F07%2F21%2Ffda-avandia-safety-review-a-done-deal%2F Six doctors with financial ties to the pharmaceutical industry, including stock holdings or speaking fees, will be among members of a U.S. advisory panel on the use of a GlaxoSmithKline Plc diabetes medicine linked to heart risks. The doctors will discuss the safety of the drug, Avandia, and similar treatments at a July 30 meeting convened by the Food and Drug Administration. As many as four of the six doctors with conflicts may vote on recommendations to the FDA, according to financial disclosure documents released by the agency. The agency wouldn’t say how many members the committee will have. The FDA was criticized by lawmakers for allowing conflicts of interest among members of an advisory panel in 2005 that concluded benefits outweighed risks for pain drugs, including Merck&#821... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=747666 Sat, 21 Jul 2007 07:15:23 +0100 747666 http://www.medworm.com/index.php?rid=744842&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F07%2F19%2Favandia-millions-worldwide-taking-part-in-a-large-scale-experiment%2F New details on the side effects of the diabetes drug Avandia have been released (New Scientist 18 July 2007), indicating it can cause 50% more weight gain than similar medications and double the risk of dangerous fluid retention in the body. A team of researchers led by Bernd Richter at Heinrich Heine University in Dusseldorf, Germany, found the latest bad news to report about Avandia. The team reviewed 18 studies, which had an average follow-up time of about six months. They found the risk of dangerous fluid retention in the body – a condition known as oedema – doubled in those taking the Avandia, compared with patients on other diabetes medications. The diabetics taking Avandia had a 7% risk of oedema – five times higher than those taking placebos. Oedema is characterised by swelli... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=744842 Thu, 19 Jul 2007 13:42:50 +0100 744842 http://www.medworm.com/index.php?rid=740487&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F07%2F17%2Fmanufacturing-consensus-adult-adhd-in-the-uk%2F The excerpt below is from David Healy’s Marketing Drugs and Changing Lives in the US… you can read more here. CONSENSUS CONFERENCES Consensus conferences aimed at producing guidelines for clinical practice came into existence in the late 1980s (Sheldon and Smith 1993). A range of bodies took up this apparently academic development. Within psychiatry, groups such as the British Association of Psychopharmacology and the European College of Neuropsychopharmacology, for example, produced guidelines on the treatment of a range of conditions from depression through to schizophrenia. This may have happened in part in an effort to establish a political profile. In a number of the organizations that produced guidelines, the influence of key individuals with links to pharmaceutical compa... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=740487 Tue, 17 Jul 2007 19:09:50 +0100 740487 http://www.medworm.com/index.php?rid=738938&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F07%2F17%2Fglaxo-threatens-us-lawyers-over-avandia-ads%2F Ed Silverman at Pharmalot is running this item. It seems that Glaxo has sent a “small number” of letters demanding lawyers pull ads they say are making false or misleading claims about links between its diabetes med Avandia and heart attacks. “Lawyers have a right to advertise, but they have to play by the rules just like we do.” Chris Viehbacher, president of Glaxo’s U.S. unit, tells Bloomberg News. The letter sent by the Philadelphia law firm Pepper Hamilton contends that the plaintiffs firm’s ads “are actionable” because they imbue the study with “a definitive, conclusory quality.” A recent study in The New England Journal of Medicine found Avandia users were 43 percent more likely to have a heart attack than those taking other diabetes meds. Perhaps someone at Peppe... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=738938 Tue, 17 Jul 2007 13:14:54 +0100 738938 http://www.medworm.com/index.php?rid=733785&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F07%2F13%2Favandia-side-effect-reports-to-fda-have-tripled%2F Since the analysis linking the diabetes med to cardiovascular risk was published May 21 in The New England Journal of Medicine, side effect reports to the FDA tripled. The sudden increase reflects the likelihood that many docs were unaware that Avandia may have caused heart problems that weren’t reported previously. With Avandia, the published analysis likely led to more cases being reported, said Vanderbilt University diabetes specialist Dr. Alvin C. Powers. “Now, patients and their doctors are much more aware of the possible link between Avandia and cardiovascular disease. This is good — this is going to help us going forward to determine whether or not this drug is safe,” he said. Glaxo spokeswoman, Mary Anne Rhyne (who I like to think of as an American Alastair Benb... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=733785 Fri, 13 Jul 2007 06:13:35 +0100 733785 http://www.medworm.com/index.php?rid=728460&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F07%2F11%2Fglaxo-caught-marketing-drugs-before-approval-from-regulators%2F An appeal board upheld a complaint by Sanofi-Aventis over the activities of GlaxoSmithKline’s cervical cancer disease awareness team which, the group claimed, collectively amounted to the promotion of its cervical cancer vaccine Cervarix before it was approved by regulators. GSK claimed that the team’s role was to educate the relevant health professionals about the burden of cervical cancer and precancerous lesions, the causal role of cancer-causing types of human papillomavirus in cervical cancer, and the importance of the screening programme. But although an initial ruling sided with GSK, a subsequent appeal ruled GlaxoSmithKline was in breach of: clause 2 and clause 3.1, promoting a medicine prior to the grant of the marketing authorisation which permits its sale or supply. Adverti... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=728460 Wed, 11 Jul 2007 22:00:33 +0100 728460 http://www.medworm.com/index.php?rid=726292&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F07%2F10%2Fbenbow-science-not-hype-will-be-the-king-here%2F  Comedy Gold… Dr Alastair Benbow, GSK’s European medical director, weighs in on the Avandia debate with all his authority…. Ali B tells us that “… Avandia’s risks have been overblown: Science, not hype, will be the king here.” He went on “Patients don’t necessarily understand the science behind these figures. You can blame the way it [the 43 per cent excess risk of heart attack] is presented as a big-ticket number when the actual numbers [the increase in risk] were very small.” Good. Fine. That’s clear then Dr Benbow… er, sorry, but what are you actually trying to say here? Read this recent complaint to the General Medical Council about Benbow and see if you think he’s up to his old tricks again, but this time with Avandia This fro... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=726292 Tue, 10 Jul 2007 21:45:31 +0100 726292 http://www.medworm.com/index.php?rid=716605&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F07%2F05%2Fglaxo-recalls-hedex-extra-from-the-market%2F …in Kenya that is. Just like GSK’s other pain relief brand, Panadol and Panadol Extra that targets more affluent consumers, Hedex Extra was launched in Kenya as a product extension to Hedex, a companion and fighter brand against the likes of Beta Healthcare’s Mara Moja and Action in a bid to carve a bigger share of Kenya’s Sh2 billion analgesic drug market. However, by the time Hedex Extra was brought to the market in January 2006, insiders knew that there were problems with the product’s formulation and there had been consumer complaints over the side effects of the drug. Yesterday, it emerged in media reports that GSK had recalled Hedex Extra from the market. Business Daily’s interviews with retailers and pharmacists reveal that GSK started withdrawing the drug from the m... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=716605 Fri, 06 Jul 2007 07:48:54 +0100 716605 http://www.medworm.com/index.php?rid=713178&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F07%2F03%2Fgo-on-talk-to-me%2F Why not? Why not just leave a comment and explain things to me - tell me how I’m wrong about you and your products, about you and the way you market them, about you and the way you harm people, about you and the data you kept hidden, about you and the regulators, about you and your lies. Talk to me - I want to hear your side of the story - I really do. Surely someone from my “visitors’ book” has something to say worth saying [except the Scientologists]: Abbott Laboratories, North Chicago, Illinois Abbott Laboratories, Gurnee, Illinois Abbott Laboratories, Libertyville, Illinois Accenture, United Kingdom Adpepper.com Allegiance Healthcare, Waukegan, Illinois American Red Cross, National Headquarters, Washington American Society of Clinical Oncology, Alexandria, Virgi... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=713178 Tue, 03 Jul 2007 21:52:46 +0100 713178 http://www.medworm.com/index.php?rid=707376&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F07%2F01%2Falastair-benbow-and-the-general-medical-council-are-the-gmc-protecting-benbow%2F Below you will find a sequence of correspondence between Charles Medawar of Social Audit and the General Medical Council. It seems the GMC does not want to investigate Dr Alastair Benbow, despite what he has said in public, on more than one occasion regarding the safety and side effects of Seroxat “…In short, and in the light of the evidence that has since become publicly available, this man’s statements on television leave the impression that he conceived his primary duty of care to be to his employers, rather than to the many people (including health professionals) likely to have trusted his judgment as a doctor…” Now read on: 1 February 2007 Dear Sirs, I am writing to enquire about the possibilities and appropriate procedures for making a complaint about a regi... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=707376 Sun, 01 Jul 2007 10:50:39 +0100 707376 http://www.medworm.com/index.php?rid=706588&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F06%2F30%2Fcan-you-believe-they-really-said-this%25e2%2580%25a6-reprise%2F Here are all those great quotes brought together in one huge post for us all to consider once again… I have no trouble making difficult decisions. I do not agonize too much just ask around. I sleep well at night. Jean-Pierre Garnier Chief Executive Officer, GlaxoSmithKline 4/5/2004 I do not need to take anything. I am fortunate to be in very good health. And you have to be well in your head. You have to enjoy not the destination, but the journey. Jean-Pierre Garnier Chief Executive Officer, GlaxoSmithKline 4/5/2004 I can’t count on people just to trust us as a company to do the right thing, even though they should. Jean-Pierre Garnier Chief Executive Officer, GlaxoSmithKline 10/4/2004 I think you have to develop a culture where if there is bad news you don’t sit on bad news. B... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=706588 Sat, 30 Jun 2007 16:49:10 +0100 706588 http://www.medworm.com/index.php?rid=704473&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F06%2F29%2Flong-term-seroxat-use-and-its-associated-health-problems%2F Have you been taking Seroxat for 5 years or more? Suffered health problems that you think could be caused by Seroxat? Then don’t tell me, but go to - ‘Seroxat: Ups and Downs’ - and let them know. It’s new forum and we all have to start somewhere, so get over there and start posting! The forum has been started by Shutah, whose signature runs like this: Prescribed 20mg Seroxat 1996 for migraines!! WHY??? Divorced 1997. Doolally 1997 onwards. Escaped to USA 1999. Completely barmy 1999 onwards. Came back to UK 2003 and tried 10mg - OMG!!! Scary time. Back up to 20mg. Ahhhhh calm again. 2004 tried 10mg again - MANIC!! Murderous!! Frightened!! 2005 put up to 30mg - wahay!! Fairyland!! 2006 down to 20mg. 2007 still on 20mg - too darn scared to try again!!! I should also pe... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=704473 Fri, 29 Jun 2007 14:12:56 +0100 704473 http://www.medworm.com/index.php?rid=699310&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F06%2F27%2Fglaxo-spends-24-billion-on-advertising-in-the-usa-alone%2F GlaxoSmithKline was America’s seventh-largest consumer advertiser in 2006, according to TNS Media Intelligence’s Stradegy as reported in Advertising Age.With ad spend of $2.4 billion, GSK placed just behind Ford and ahead of Walt Disney, moving up from ninth-largest in 2005. J&J, last year’s No. 4 advertiser, slipped in the ranking to place ninth – still beating out the likes of Unilever, Toyota and Sony. Further down the list were clustered Pfizer, at 31, with $1.1 billion in ad spend, and Wyeth (33), Novartis (36), Merck (38), AstraZeneca (40) and Schering-Plough (42), all in the neighborhood of $1 billion. The survey covered TV, magazine, newspaper, outdoor, radio and internet advertising. Perennial No. 1 P&G weighed in at $4.8 billion in measured media. You&... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=699310 Wed, 27 Jun 2007 08:03:11 +0100 699310 http://www.medworm.com/index.php?rid=699311&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F06%2F27%2Fpaxil-prozac-and-ssri-induced-suicide-jeffery-dach-md%2F Dr Dach writes: According to Irving Kirsch in Prevention & Treatment , “there is now unanimous agreement that the mean difference between response to antidepressant drugs and response to inert placebo is very small. It is so small that, despite sample sizes involving hundreds of participants, 57% of the trials funded by the pharmaceutical industry failed to show a significant difference between drug and placebo. Most of these negative data were not published and were accessible only by gaining access to US Food and Drug Administration (FDA) documents. The small difference between the drug response and the placebo response has been a “dirty little secret”. It was not known to the general public, depressed patients, or even their physicians”(link). Various methods were... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=699311 Wed, 27 Jun 2007 07:57:30 +0100 699311 http://www.medworm.com/index.php?rid=696898&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F06%2F26%2Fseroxat-linked-to-osteoporosis-risk%2F Good to see everyone catching up with Seroxat Secrets! - I first mentioned the Seroxat/osteoporosis link back in January. It appears there are now two more studies that are showing the same results. Taking commonly-prescribed antidepressants such as Seroxat may lead to lower bone density and the risk of osteoporosis in older men and women. Two separate studies in the US found that people who used the pills, known as selective serotonin re-uptake inhibitors (SSRIs), developed thinner bones than those who did not take them. Channel 4 has the full story here. (Source: seroxat secrets...) seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=696898 Tue, 26 Jun 2007 14:46:37 +0100 696898 http://www.medworm.com/index.php?rid=694207&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F06%2F25%2Fmhra-breckenridge%2F I’ve just read a piece at Seroxat Sufferers - Alasdair Breckenridge (head of the MHRA) is speaking about Seroxat, from The New Statesman in 2005. It seems Breckenridge was happy that the MHRA had been up to speed on the Seroxat scandal from the very beginning: “If you go back - and I read this out to the Health Select Committee - to the data sheet on Seroxat when it was licensed in 1991, we spelt out word for word the problems of withdrawal from Seroxat, in words that we could not improve now. This idea that the regulators have been hiding the data is just not true. The so-called scandal of Seroxat is something I want to nail every time I speak in front of compatriots because it is absolute rubbish”. And here is what Breckenridge actually said to the Health Select Committ... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=694207 Mon, 25 Jun 2007 08:56:55 +0100 694207 http://www.medworm.com/index.php?rid=692379&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F06%2F23%2Falli-side-effects-or-treatment-effects%2F So Glaxo have entered the blogosphere with alliconnect in order to sell their new drug: “You may have heard about alli by now. It’s the only FDA-approved OTC (over the counter) weight loss product. We’ve launched alli with a major advertising campaign (see our TV ads on YouTube). We’ve started this blog (yes, it’s the official alli corporate blog) in order to do something a bit different”. Problem is, no one will be taken in by Glaxo and this latest soft-sell initiative. The truth about alli is much more like this: Drug Company VP Admits New Diet Drug Made Him Crap His Pants and the (very) unofficial alliconnect blog which paints a realistic picture about Glaxo and the deeply cynical nature of the way it does business… Lastly, can I just ask someon... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=692379 Sat, 23 Jun 2007 14:52:24 +0100 692379 http://www.medworm.com/index.php?rid=690034&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F06%2F22%2Fthe-truth-about-glaxos-weight-loss-wonder-alli%2F Mr Angry, of the excellent blog “Angry 365 Days a Year” has been looking at Glaxo’s latest and greatest drug - the weight loss wonder(?) - alli. He’s been looking at the alli website and has provided us with a useful translation of the marketing copy that Glaxo paid so much to get written: Website Bullshit (WSBS): You may get: gas with oily spotting, loose stools more frequent stools that may be hard to control No BS: The following things will happen to you: You will spray oil when you fart You will have diarrhoea You will be shitting constantly and you will lose control of your bowels to the point where you shit your pants WSBS: The excess fat that passes out of your body is not harmful. In fact, you may recognize it as something that looks like the oil on top ... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=690034 Fri, 22 Jun 2007 07:28:43 +0100 690034 http://www.medworm.com/index.php?rid=687026&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F06%2F21%2Fhow-addictive-is-seroxat%2F   You might think that after all the years of doctors and patients all around the world saying Seroxat is highly addictive - oops, sorry, causes dependence and severe withdrawal reactions - that Glaxo would simply undertake the definitive study to prove us all wrong and to show the world once and for all really how safe and non-addictive Seroxat is… Well, the truth is Glaxo could have done this years ago but it has not. Why? I leave that simple question to you to answer. In fact, the official Paxil prescribing information (produced by Glaxo, current version) confirms this by saying: DRUG ABUSE AND DEPENDENCE Controlled Substance Class: PAXIL is not a controlled substance. Physical and Psychologic Dependence: PAXIL has not been systematically studied in animals or humans for its ... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=687026 Thu, 21 Jun 2007 12:35:21 +0100 687026 http://www.medworm.com/index.php?rid=683154&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F06%2F19%2Feducation-or-advertising%2F Many thanks to Dr Carlat and his new Carlat Psychiatry Blog for this piece - in fact you may remember it was Dr Carlat who wrote an excellent op-ed piece in the New York Times recently about Continuing Medical Education (CME). It seems Glaxo is up to its old tricks again - being VERY selective with the data they use to argue their case and in fact ignoring and burying the negative data. Read on: GlaxoSmithKline just released a web-based CME slide show entitled, “Improving Outcomes in Patients with Bipolar Disorder: Exploring the Distinction Between Efficacy and Effectiveness,” which you can view here. Terence Ketter of Stanford gives the talk, but all the content was created by medical writers paid by GSK (via an educational grant to that well-known academic institution, The C... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=683154 Tue, 19 Jun 2007 07:47:52 +0100 683154 http://www.medworm.com/index.php?rid=683157&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F06%2F17%2Fim-trapped-mother-sues-glaxo-over-seroxat-damage%2F A SCOTS mum is to sue drugs giant GlaxoSmithKline after claiming their antidepressant Seroxat made her scared to leave her home, according to the Sunday Mail in Scotland Diane Smith claims she became agoraphobic when she tried to wean herself off the controversial drug. She even missed her son’s wedding and could not go to see her dying father as she has become a prisoner in her own home. Diane, 43, of Thurso, Caithness, has issued a writ in the High Court in London claiming £50,000. Seroxat has been linked to a string of suicides and users say they have suffered serious side effects, including depression. Diane’s case is the first to be lodged over the effects of coming off the drug. Her action was launched this year to beat an English High Court 10-year timebar as she starte... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=683157 Sun, 17 Jun 2007 17:45:38 +0100 683157 http://www.medworm.com/index.php?rid=675875&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F06%2F15%2Fand-while-were-talking-about-study-329-here-are-some-seroxat-secrets%2F I know it’s going over old ground, but I’m prompted to write this by the recent posts at Scientific Misconduct and Seroxat Sufferers about Marty Keller and Study 329. Firstly we must go back to October 1998 to an internal, confidential SmithKline Beecham document about studies 329 and 377. In summary it says “… the data do not support a label claim for the treatment of Adolescent Depression… efficacy had not been demonstrated.” Specifically about Study 329 “…the study failed to demonstrate a statistically significant difference from placebo on the primary efficacy measures.” In other words - it didn’t work. About Study 377 we read “… failed demonstrate [sic] any separation of Seroxat/Paxil from placebo.” In othe... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=675875 Fri, 15 Jun 2007 17:03:32 +0100 675875 http://www.medworm.com/index.php?rid=675876&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F06%2F15%2Fpsychiatrist-indicted-for-fraud-in-paxil-trials%2F NEW ORLEANS — Dr. Maria Carmen Palazzo was indicted by a federal grand jury on 55 counts of health care fraud and false documentation in connection with a clinical trial of Paxil in children and adolescents, U.S. Attorney Jim Letten said on Thursday. The indictment alleges that during approximately a five-year period, Palazzo, 55, of New Orleans, defrauded Medicare in connection with services she claimed to have rendered to patients in a Psychiatric Partial Hospitalization Program at Touro Infirmary. The indictment also charges that Palazzo defrauded Medicare by submitting fraudulent invoices to Touro for consulting and medical director services. The indictment says because of that Medicare paid Palazzo over $653,000 she was not entitled to receive. Palazzo, who specializes in psychi... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=675876 Fri, 15 Jun 2007 15:38:41 +0100 675876 http://www.medworm.com/index.php?rid=675456&cid=t_113167_87_f&fid=34867&url=http%3A%2F%2Fwww.thediabetesblog.com%2F2007%2F06%2F13%2Fjanuvia-actos-set-to-benefit-from-avandias-plight%2F Filed under: Type 2, Drugs, ResearchAvandia, a drug used to treat Type 2 diabetes, has been in the news of late following the release of controversial study results which concluded the drug leaves patients at an increased risk for heart trouble. My fellow blogger Bev has touched on the conundrum now facing diabetics on Avandia regimens. You can quit taking Avandia, but then what? Thousands of Americans are now facing this predicament and many have opted to switch their prescriptions to something else. The Philadelphia Inquirer is running a feature about this and talks to some diabetics who have opted for the "try something else" route. The Inquirer profiles, among others, pharmacist Ben Briggs, 59, who switched to Merck's Januvia in the wake of the Avandia scandal, but was sorely disappoin... The Diabetes Blog blogs http://www.medworm.com/rss/comments.php?id=675456 Wed, 13 Jun 2007 04:00:00 +0100 675456 http://www.medworm.com/index.php?rid=675882&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F06%2F11%2Ffda-and-glaxo-share-blame-for-avandia-disaster%2F By Evelyn Pringle On May 21, 2007, the New England Journal of Medicine reported a study that found GlaxoSmithKline’s diabetes drug Avandia is associated with a 43% increase in heart attacks and possibly a 64% increase in cardiovascular death. The NEJM said it posted the article online ahead of its June 6, 2007 print edition because of its medical importance. Experts point out that the studies analyzed for the NEJM report were not designed to look for heart risks, many were only 24 weeks long, and it may be that higher risks will appear after a longer term of use. Dr David Nathan, chief of diabetes care at Massachusetts General Hospital, who reviewed the paper for the NEJM, told the Associated Press, “This analysis is just scratching the surface of what may be there.” The... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=675882 Mon, 11 Jun 2007 11:48:30 +0100 675882 http://www.medworm.com/index.php?rid=675883&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F06%2F09%2Fthe-profitable-anti-seroxat-bandwagon%2F This post has been prompted by a series of increasingly distasteful and personal emails that Bob Fiddaman got from one Jim Thomson. When the going gets tough, the tough get personal. That seems to be the message from Big Pharma - disagree with us and we’ll soon find ways to put you in your place. You might have though that experts such as Professor David Healy, Richard Brook, Charles Medawar, Dr Peter Breggin, Dr Andrew Herxheimer et al were the good guys. You might have thought that campaigning MPs like Paul Flynn and organisations such as MIND and Panorama were on your side - making an honest stand against the spin, deception and lies of companies like Glaxo and Lilly. Well that’s not the case says big pharma - more and more I see the good guys dismissed as cranks who care fo... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=675883 Sat, 09 Jun 2007 19:55:37 +0100 675883 http://www.medworm.com/index.php?rid=676283&cid=t_113167_134_f&fid=35137&url=http%3A%2F%2Fdiabetesupdate.blogspot.com%2F2007%2F06%2Fresearcher-threatened-with-4b-suit-for.html Here, from the Boston Globe, are more details about how John Buse, the mainstream researcher who will be the next ADA presidents, was threatened by GlaxoSmithKline, the maker of Avandia, for calling attention to its tendency to cause heart problems.Scientist says executive of Avandia firm tried to bully - Boston GlobeFrom the article:"An executive of the company that makes the diabetes drug Avandia said a researcher who was among the first to link it to heart problems would be held liable for the $4 billion GlaxoSmithKline PLC lost in stock value as a result of his findings, Dr. John B. Buse testified before congressional investigators yesterday.This information came from testimony, under oath, to congress."Buse told the House Committee on Oversight and Government Reform that he raised con... Diabetes Update blogs http://www.medworm.com/rss/comments.php?id=676283 Fri, 08 Jun 2007 12:42:00 +0100 676283 http://www.medworm.com/index.php?rid=660479&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F06%2F06%2Favandia-can-make-some-heart-problems-worse-or-lead-to-heart-failure-says-glaxo%2F The irony of it all - in support of Avandia, Glaxo has been forced to take out full page ads in publications such as The New York Times, The Washington Post, USA Today and The Wall Street Journal. These ads which are intended to reassure patients of the safety of the widely used medicine take the form of a letter to Avandia patients signed by Ronald Krall, chief medical officer of the world’s second- largest drugmaker. The four paragraph letter concludes, “Be assured, GSK gives you our full commitment to providing you and your doctor with the facts about the safety of Avandia.” However, about a quarter of the newspaper page is taken up by obligatory safety warnings in the same prominent typeface used for the letter. It includes a caution that Avandia can cause fluid reten... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=660479 Wed, 06 Jun 2007 09:20:20 +0100 660479 http://www.medworm.com/index.php?rid=655516&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F06%2F04%2Favandia-critic-to-tell-how-he-was-intimidated-by-glaxo%2F Discussions occurred with Dr. John Buse in 1999 and 2000 regarding his views on Avandia, and we had a scientific disagreement that was later resolved. We regret if, at any time, Dr. Buse felt the conduct of any GSK employee was contrary to the spirit of open, scientific debate regarding his views on Avandia.” The statement also said that the company “does not condone any efforts by GSK’s staff to limit an individual’s ability to discuss or publish adverse events related to Avandia.” Dr. Buse’s friend, Dr. Burant, said in a telephone interview, “I never wrote a prescription for Avandia because of the heavy-handed way Glaxo treated John Buse.” When Glaxo sales representatives have asked him why he was not prescribing Avandia, “I was very straight with them,” Dr. Burant re... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=655516 Mon, 04 Jun 2007 08:36:05 +0100 655516 http://www.medworm.com/index.php?rid=651062&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F06%2F02%2Favandia-negative-data-why-would-you-publicize-it-says-jp-garnier%2F More on Glaxo and Avandia - Andrea Gerlin at Bloomberg continues to investigate the drug maker and its latest problem medicine: Glaxo, Top Ad Spender, Didn’t Publicize Avandia Risks GlaxoSmithKline Plc was the drug industry’s top advertiser last year [2006], promoting its asthma and diabetes treatments to patients and doctors. Information the company didn’t make well known is now drawing more attention. London-based Glaxo knew its Avandia diabetes pill posed a risk for heart and circulatory complications as early as 1999, when the medicine won U.S. approval. The cardiovascular concern wasn’t widely disseminated until May 21 [2007] when a Cleveland Clinic Foundation analysis reported that Avandia may cause a 43 percent higher risk of heart attacks than other drugs. A... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=651062 Sat, 02 Jun 2007 08:49:40 +0100 651062 http://www.medworm.com/index.php?rid=651064&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F05%2F31%2Fthis-is-what-its-all-about%2F Truthman30 made a comment on one of my recent posts …Let’s get Paxil out of mouths and into the garbage, that’s where it belongs… I think he’s hit the nail on the head “The thing is , it should never have been licenced… I have long been calling Seroxat the mental health thalidomide, even before the recent indications of Seroxat inducing malformations in new-borns I had thought of it as such. But, I wasn’t prepared for the absolute shock and horror I experienced when I read the news last year about these poor babies being harmed by this defective and toxic medication. It is an absolute and total disgrace, and GSK should be paying for Public Health Adverts on TV and full page adverts in every newspaper and magazine alerting everybody about this. It is another thal... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=651064 Thu, 31 May 2007 16:11:54 +0100 651064 http://www.medworm.com/index.php?rid=645102&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F05%2F30%2Fits-all-going-wrong-for-jean-pierre-garnier-at-glaxo%2F As Chief Executives go, JP Garnier has always been VERY well paid. But in order to justify his huge salary JP needs to deliver - and he’s not - in fact, he is fast becoming an embarrassment to the company. When Garnier said “I’ll be a hero in three years.” (5 May 2004), I’m not quite sure this is what he had in mind! At Glaxo’s AGM last week shareholders voiced their anger over the poor performance of GSK’s share price, which has dropped by almost 15% over the past year. GSK investor John Farmer blasted the group for its “colossal under-performance” and demanded the resignation of chairman Sir Christopher Gent and a more speedy exit for CEO Jean-Pierre Garnier. Garnier is not due to step down until May 2008. The current controversy over Av... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=645102 Wed, 30 May 2007 07:32:17 +0100 645102 http://www.medworm.com/index.php?rid=645103&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F05%2F29%2Fglaxo-share-price-down-further-still-as-avandia-prescriptions-reach-zero%2F It’s not looking good for Glaxo as prescriptions for Avandia reach… a bit fat ZERO. Glaxo Avandia Prescriptions Fall, Deutsche Bank Says - writes Andrea Gerlin at Bloomberg May 29 Avandia’s share of new oral diabetes prescriptions fell to about zero from 10 percent in the two days after the May 21 report in the New England Journal of Medicine, Deutsche Bank analysts wrote in a note. Takeda Pharmaceutical Co.’s diabetes drug Actos’ share climbed to 22 percent from 10 percent, the analysts wrote, citing data from market research firm Impact Rx. “This reaction is far worse than we had anticipated and suggests that there could be as much as 22 percent downside risk to GSK’s near-term earnings, suggesting that there is still further downside to GSK&#8... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=645103 Tue, 29 May 2007 15:36:15 +0100 645103 http://www.medworm.com/index.php?rid=645105&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F05%2F29%2Fup-to-100000-heart-attacks-might-be-linked-to-glaxo-drug%2F This from the Washington Post last Friday (thanks to Truthman30 for the link): FDA Study Said to Show Avandia Risk By MARILYNN MARCHIONE The government’s own preliminary evaluation of the diabetes pill Avandia confirms the heart risks reported in a study earlier this week and suggests that as many as 60,000 to 100,000 heart attacks might be linked to its use since it came on the market eight years ago, a leading member of Congress said Thursday. In a floor statement placed in the Senate record, Sen. Charles Grassley also said that safety watchdogs within the federal Food and Drug Administration “several months ago” recommended a “black box” on the drug’s label - the strongest possible warning. It is the first confirmation that the FDA’s own analysi... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=645105 Tue, 29 May 2007 06:52:51 +0100 645105 http://www.medworm.com/index.php?rid=638914&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F05%2F27%2Fmore-on-glaxo-and-avandia%2F This editorial from the New York Times: Ignoring the Warnings, Again? The latest findings on Avandia, a top-selling diabetes drug, raise concerns both about its safety and about the way the manufacturer and the Food and Drug Administration have responded to signs of danger. It would be rash to make definitive judgments until the F.D.A. completes a detailed analysis. But the handling of this case bears disturbing resemblances to the Vioxx debacle, in which early warning signs were ignored by its manufacturer until the evidence of serious harm became inescapable and the drug was pulled from the market. Avandia was approved for sale in 1999 based on studies showing that it could lower blood glucose levels in patients suffering from Type 2 diabetes, also known as adult-onset diabetes. The assu... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=638914 Sun, 27 May 2007 10:15:07 +0100 638914 http://www.medworm.com/index.php?rid=638135&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F05%2F25%2Flets-get-paxil-out-of-mouths-and-into-the-garbage-thats-where-it-belongs%2F That quote is from Cindy, who is the Aunt of a young boy called Manie. Yep - you guessed it, Manie’s mother, Julie took Seroxat (Paxil) when she was pregnant with Manie. If Glaxo had been quicker to properly warn pregnant women about the risks this might not have happened. Julie’s new blog is here - big pharma victim - need I say any more? “I had a normal pregnancy with Manie. I even had a couple of ultrasounds done while I was pregnant with Manie. There were no clues that Manie had a rare heart defect. I had already 3 perfectly healthy kids and did not expect for Manie to be any different. As soon as Manie was born he began to turn blue. The more he cried the more he turned blue. Our doctor did not know what was wrong with Manie. The doctor thought that it might be his ... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=638135 Sat, 26 May 2007 12:44:52 +0100 638135 http://www.medworm.com/index.php?rid=638136&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F05%2F25%2Fseroxat-and-the-foetus%2F Glaxo admits that Seroxat can double the risk of heart defects and other malformations in babies born to Mothers ingesting Seroxat during pregnancy. This has been well documented already and the FDA and MHRA have issued warnings recently about the risks to newborns and the unborn. Seroxat was also recently reclassified from a category C drug to a category D… Which means it does “officially” pose a significant risk to the foetus… To find out more, I suggest you read Truthman30’s excellent post about this sensitive issue. (Source: seroxat secrets...) seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=638136 Fri, 25 May 2007 10:44:17 +0100 638136 http://www.medworm.com/index.php?rid=638137&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F05%2F24%2Fwhat-its-all-about%2F Sometimes I forget why I do this, but then I remember, it’s not really about big business, drug marketing and corruption - it’s actually about people - people and their stories. And you will hear the same stories literally the world over. The experiences are so similar it’s frightening. It doesn’t matter if you’re from London or New York; Birmingham or Melbourne; Dublin or Bahrain - if you have had problems taking, or withdrawing from, an SSRI, then people’s experiences will be all too similar. And how many of us might suffer? To begin with, withdrawal was not even mentioned on the early Seroxat PILs. Later when it was mentioned on the PIL, it was rare - 0.2%. Then on 25 June 2003 the PIL was quietly rewritten by Glaxo and withdrawal became a likely i... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=638137 Thu, 24 May 2007 18:03:48 +0100 638137 http://www.medworm.com/index.php?rid=631607&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F05%2F23%2Favandia-%25e2%2580%2593-diabetes-drug-called-potential-death-risk%2F There’s a very good post about Avandia over at Aftermath News. It references the USA Today article “Diabetes drug called potential death risk.” I know I’m a little behind with this breaking story, but I thought as Glaxo is looking in on Seroxat Secrets quite few times a day, I’d better give it something to think about - Glaxo, you can run but you can’t hide anymore… the internet is seeing to that. I’ve said it before and I’ll say it again - pharma’s business model is broken - the science will not let it be sustained any longer. The age of the truly innovative blockbuster drug (and the massive profits) is over - that’s why drug companies continue to market sub-standard products to the public. And that is also the reason why... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=631607 Wed, 23 May 2007 16:55:04 +0100 631607 http://www.medworm.com/index.php?rid=631608&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F05%2F23%2Fglaxos-avandia-%25e2%2580%2593-exposed-much-as-vioxx-was-exposed%2F Will someone out there please tell me how much longer we are going to have to put up with stories like this? “A meta-analysis of the clinical trial data shows that GlaxoSmithKline’s diabetes blockbuster, Avandia, increases the risk of heart attacks and cardiovascular related deaths. Once again the FDA is shown to be asleep at the helm-its approved drug label and cannot be trusted to protect the public from unsafe drugs that kill. Anna Wilde Matthews of The Wall Street Journal reports: “Dr. Nissen started his quest to gather data about Avandia’s risks last year, after he spotted what he thought were hints of trouble in published studies. Along the way, he set congressional investigations into motion, and, last month, hit pay dirt with a Google search that pointed him... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=631608 Wed, 23 May 2007 16:24:59 +0100 631608 http://www.medworm.com/index.php?rid=631576&cid=t_113167_87_f&fid=34866&url=http%3A%2F%2Fwww.thecardioblog.com%2F2007%2F05%2F23%2Favandia-and-avandamet-tied-to-heart-risks%2F Filed under: Drugs, Daily newsIn a scary bit of news that affects more than 6 million Americans, a drug commonly used to treat diabetes has been linked to increased risk for heart attacks and death. The drug, sold as Avandia or Avandamet, has been on the market for 8 years and has been widely used by diabetes patients to help control blood sugar levels. This is even more concerning due the fact that diabetes patients are already at risk for heart problems without possibly making things worse by using medication that is supposed to be helping, not hurting, their health.Experts warn that people shouldn't panic and stop taking any prescription medication suddenly, but should instead visit with their doctor about any changes that may need to be made.Read | Permalink | Email... The Cardio Blog blogs http://www.medworm.com/rss/comments.php?id=631576 Wed, 23 May 2007 04:00:00 +0100 631576 http://www.medworm.com/index.php?rid=629221&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F05%2F22%2Fwatching-you-watching-me%2F During the last week, I thought I’d try some analysis of vistors to my blog (thanks to Bob Fiddaman for the title of this post). It’s been an interesting exercise to monitor the traffic for the last 7 days - I’ve had a few visits from the ‘great and the good’ in amongst my 800 or so daily hits. In amongst all the familiar names to you, you’ll perhaps see some companies you’re not so familiar with - these will probably be the Ad agencies and PR firms that work for pharmaceutical clients. Seroxat Secrets corporate visitors 15-22 May 2007 Abbott Laboratories, Gurnee, Illinois Adpepper.com Allegiance Healthcare, Waukegan, Illinois Aventis Pharamceuticals, New Jersey Bausch & Lomb, Rochester, New York Biogen, West Roxbury, Massachusetts Boehringer I... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=629221 Tue, 22 May 2007 09:17:36 +0100 629221 http://www.medworm.com/index.php?rid=623581&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F05%2F19%2Fmichael-moores-sicko-at-cannes%2F Documentary-maker Michael Moore’s new film Sicko has become one of the most talked-about productions at the Cannes Film Festival. This link will take you to a BBC round-up of what the early reviews say. (Source: seroxat secrets...) seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=623581 Sun, 20 May 2007 11:55:27 +0100 623581 http://www.medworm.com/index.php?rid=623584&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F05%2F18%2Ffrom-the-horses-mouth%2F Just take a moment to read this: Paxil CR and Paxil are approved only for adults 18 years and over. In some children and teens, antidepressants increase suicidal thoughts or actions. Young adults, especially those with depression, may be at increased risk for suicidal actions. Whether or not you are taking antidepressants, you or your family should call the doctor right away if you have worsening depression, thoughts of suicide, or sudden or severe changes in mood or behavior (for example feeling anxious, agitated, panicky, irritable, hostile, aggressive, impulsive, severely restless, hyperactive, overly excited, or not being able to sleep), especially at the beginning of treatment or after a change in dose. Don’t stop taking Paxil CR and Paxil before talking to your doctor since sid... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=623584 Fri, 18 May 2007 06:30:15 +0100 623584 http://www.medworm.com/index.php?rid=623585&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F05%2F18%2F%25e2%2580%259csicko%25e2%2580%259d-is-completed-and-michael-moores-off-to-cannes%2F This from Michael Moore yesterday: Friends, It’s a wrap! My new film, “Sicko,” is all done and will have its world premiere this Saturday night [May 19th] at the Cannes Film Festival. As with “Bowling for Columbine” and “Fahrenheit 9/11,” we are honored to have been chosen by this prestigious festival to screen our work there. My intention was to keep “Sicko” under wraps and show it to virtually no one before its premiere in Cannes. That is what I have done and, as you may have noticed if you are a recipient of my infrequent Internet letters, I have been very silent about what I’ve been up to. In part, that’s because I was working very hard to complete the film. But my silence was also because I knew that the health care industry — an industry which makes up more t... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=623585 Fri, 18 May 2007 05:39:18 +0100 623585 http://www.medworm.com/index.php?rid=612258&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F05%2F16%2Fsicko-premiers-this-saturday-may-19-look-out-glaxo-lilly-pfizer%2F Do I know something that Glaxo, Lilly and Pfizer don’t know about Sicko…? Not long to wait now! This from the Times Online: Harvey Weinstein, the American film mogul, touched down in Cannes yesterday with a crack team of lawyers and PRs briefed to cushion a predicted backlash at SICKO, Michael Moore’s expose of the US healthcare system. The film was financed by the Weinstein Company and is set to screen on Saturday. Earlier, Weinstein told journalists that the film’s negative had been spirited from the US to prevent government attempts to seize it. “It was like a middle-of-the-night operation from a spy novel, moving your negative to another country,” he said. Moore’s latest polemic is expected to prove even more controversial than his 2004 Palme d’Or winner Fahrenh... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=612258 Wed, 16 May 2007 20:24:05 +0100 612258 http://www.medworm.com/index.php?rid=603435&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F05%2F12%2Fseroxat-comics-all-3-together%2F I thought it might be an idea to put all three Seroxat comics together on one post for you all to download: Comic 1 Comic 2 Comic 3 I’m not sure which one I like best - it’s maybe a bit unfair to pick on poor Alastair Benbow quite so much because Breckenridge was just as useless when he was interviewed on Panorama. OK - I’m sorry, I’ve had a chance to reconsider that last remark - I take it back. Pick on Benbow as much as you like, he deserves it! You’ll remember that Benbow is the man, who, when asked on television by pharmacology expert Dr Andrew Herxheimer about why GSK had given no warning about the severe reactions from Seroxat despite knowing about it for 5 years… simply replied “Seroxat has provided countless benefits to many people and enabled t... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=603435 Sat, 12 May 2007 17:53:00 +0100 603435 http://www.medworm.com/index.php?rid=603441&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F05%2F09%2Fsicko-29-june-release-date%2F May 9th, 2007 Weinsteins set ‘SiCKO’ release date Moore film to rollout June 29 The Weinstein Co. has pegged a June 29 rollout for Michael Moore’s Cannes-bound docu “SiCKO” and brought in Lionsgate to partner on releasing the documaker’s first pic since “Fahrenheit 9/11.” Harvey Weinstein said that he sees “SiCKO” as a less controversial film than “Fahrenheit.” “I’ve seen this movie with Republicans and Democrats, and this is one time Michael has sort of unified everyone,” he said. “The health care industry might not have a very good July Fourth.” And don’t forget it’s Cannes next week – this is Moore’s third film in a row to be an “Official Selection” at th... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=603441 Wed, 09 May 2007 19:03:09 +0100 603441 http://www.medworm.com/index.php?rid=603443&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F05%2F08%2Ffabre-kramer-refiles-gepirone-er-with-the-fda-for-the-treatment-of-major-depressive-disorder%2F I said watch this space… Tue, 08 May 2007 13:06:00 GMT LONDON, PHILADELPHIA and HOUSTON — Fabre- Kramer Pharmaceuticals Inc. and GlaxoSmithKline announced today the submission by Fabre-Kramer to the Food and Drug Administration of an amendment to the New Drug Application for gepirone extended release (ER). The amendment responds to the FDA’s June 2004 request for an additional positive short term efficacy trial for gepirone ER. Fabre-Kramer is seeking marketing approval of gepirone ER for the treatment of major depressive disorder. Fabre-Kramer and GlaxoSmithKline entered an agreement in February of this year for collaboration on the worldwide development and commercialization of gepirone ER. I’ve already written about Gepirone ER here, here and here. I wonder if a... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=603443 Tue, 08 May 2007 18:44:51 +0100 603443 http://www.medworm.com/index.php?rid=589559&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F05%2F05%2Fthe-drug-pushers-love-that-aropax-smile%2F I often write about drug marketing and the way big pharma operates. Regular readers will perhaps have picked up that I’m not a fan. In Australia – see this post over at Seroxat Sufferers – Glaxo has used its ’support’ of Comic Relief in recent years to help in its sales of Australian Seroxat - Aropax: “…GlaxoSmithKline, whose campaign of support for Comic Relief has some similarities to its advertising for one of Australia’s top-selling anti-depressant drugs. “Love that Aropax smile,” reads a six-page fold-out ad that appeared in doctors’ news magazines at the end of last year. It is trimmed in bright orange and features a formerly depressed mother joking with an orange segment in her mouth, and her giggling, orange-clad daughter. E... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=589559 Sat, 05 May 2007 06:49:53 +0100 589559 http://www.medworm.com/index.php?rid=579697&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F04%2F30%2Fhow-the-seroxat-pil-has-changed-over-the-years%2F The patient information leaflet, I mean. Thanks to one of my colleagues, Derek Scott, I’m able to supply what is truly a historic document - the very first Seroxat PIL - click on the link to download it - Original Seroxat PIL 1990 . This is a relic of a bygone age - a much simpler time for all of us. Download it and you’ll be able to read a short two page document that bears little in common with the current PIL. One thing of note is that in 1990 the PIL still stated clearly “Always keep medicine out of the reach of children. ‘Seroxat’ is not recommended for use by children.” I’ve another PIL for you to download here - Seroxat PIL 1996 - I thought I’d include this one as it is the very text I read at the time I started to take Seroxat. This h... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=579697 Mon, 30 Apr 2007 22:19:20 +0100 579697 http://www.medworm.com/index.php?rid=577139&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F04%2F29%2Falastair-benbow-yet-more-questions%2F Matthew Holford has been at it again (does the man ever stop?)… see below for his latest note to those MHRA stalwarts Stephen Fawbert, Jan MacDonald and Sarah Walk: Dear Stephen, Jan and Sarah, Further to my recent enquiries, concerning PILs and the EWG Report, are you able to add in one further item, please? That is, are you able to confirm the date upon which the risk of suicide was first acknowledged/approved by GSK/MHRA on the Seroxat PIL? I am interested in this point, because I note from Stephen’s previous replies that a UK exercise in 2000 identified the issue, and that GPs were advised accordingly, shortly thereafter. However, GSK, in the person of Dr Alistair Benbow, an officer of the Company, was publicly arguing the absence of any risk, at least as recently as 2003. ... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=577139 Sun, 29 Apr 2007 21:41:39 +0100 577139 http://www.medworm.com/index.php?rid=573947&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F04%2F27%2Fanother-take-on-the-latest-glaxo-payout%2F Another take on the preliminary ruling that indicates GlaxoSmithKline should pay out $63.8 million to make amends for making misleading claims about its antidepressant Paxil (Seroxat) in kids. CL Pysch writes: “I wonder if the authors who stamped their names on the the main ghostwritten “scientific” publication for Paxil in kids should also be shelling out some cash. After all, it was the paper (chock full of HUGE misinterpretations of the study data) with their names on it that was doubtlessly used as part of the Paxil in kids marketing campaign. Were these “independent” academics innocent parties who were misled by the corporate meanies at GSK? Or, conversely, were these academics an integral part of the marketing team and should they also be held accountabl... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=573947 Fri, 27 Apr 2007 19:26:01 +0100 573947 http://www.medworm.com/index.php?rid=571300&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F04%2F26%2Falastair-benbow-caught-out%2F My previous post took you to the Panorama interactive forums… thanks to Truthman30 for this comment that set me thinking: Check out the end of this program… It is worth watching purely for Alastair Benbow’s final words which end the discussion in the closing minutes.. When asked by (pharmacology expert) Dr Andrew Herxheimer about why GSK had given no warning about the severe reactions from Seroxat despite knowing about it for 5 years… Benbow replies… (and stumbles with) “Seroxat has provided countless benefit to many people and enabled them to do more, live longer and feel better… and I think that speaks for itself…” And my point is…? Well, what annoys me greatly is that, when asked a direct question about the safety of Seroxat, Benbow’s answer was to ... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=571300 Thu, 26 Apr 2007 10:45:13 +0100 571300 http://www.medworm.com/index.php?rid=569956&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F04%2F25%2Fpanorama-interactive-forums-watch-here%2F I’ve just been prompted by an email from a friend to post up these links to three Panorama interactive web forums that took place after broadcasts of the Seroxat programmes. They’re worth watching to see our good friend Alastair Benbow in full flow defending Seroxat as only he can… you also get to see Charles Medawar, David Healy and Andrew Herxheimer. 14 October 2002 11 May 2003 13 July 2003 (Source: seroxat secrets...) seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=569956 Wed, 25 Apr 2007 18:07:33 +0100 569956 http://www.medworm.com/index.php?rid=565421&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F04%2F24%2Fseroxat-comic-3%2F Well now, will you look at what just turned up - a new Seroxat comic called “Buying Our Silence”. Quite apt really, given what’s going on in the High Court in London… I wonder what the media would make of this case if it ever did come to court. Just imagine all the damaging detail that would come out - I doubt Glaxo would ever sell another drug again. Panorama is one thing, the High Court is quite another The two links here will take to the first Seroxat comic and the second one… …and this link will take you to a previous post Buying Our Silence, which I might humbly suggest was part of the inspiration for this latest Seroxat comic? Click on the pages to see a full size image and then download and distribute as you like - but remember, I’m sure i... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=565421 Tue, 24 Apr 2007 06:25:12 +0100 565421 http://www.medworm.com/index.php?rid=560379&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F04%2F22%2Fthe-house-of-commons-glaxo-the-mhra%2F I came across this little gem amongst all the old stuff I’ve got on my computer: it’s from the House of Commons Health Select Committee - The Influence of the Pharmaceutical Industry evidence sessions - I’d just like to thank Dr Dollow from GSK for explaining this to me so well: Q713 Dr Naysmith (Committee): We are getting a bit short of time now, but could I quickly ask GSK about Seroxat and the fact that, up until quite recently, June 2003, the company maintained that withdrawal symptoms from Seroxat were very rare, round about 0.1 per cent was the figure, and now you have to accept that it is nearly 25 per cent. How did that come about? There is evidence that you knew before June 2003 that the figure you were using was wrong. Dr Dollow (GSK): I think it is important to... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=560379 Sun, 22 Apr 2007 09:15:14 +0100 560379 http://www.medworm.com/index.php?rid=560380&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F04%2F22%2Ffestival-de-cannes-and-sicko%2F Every year I look forward to the Cannes Film Festival. OK, well not every year. But this year… do you know what, I think I might well be looking foward to it quite a lot. Each year, about twenty feature films are selected to be in Competition and in the running for the Palme d’Or. They make up the main part of the Official Selection which is screened at the Grand Theatre Lumière. A certain number of feature films are presented Out-of-Competition in either the Grand Theatre Lumière or Buñuel theatre. It really is a spectacular time to launch a new movie onto an unsuspecting public - the whole world watches what goes on at Cannes… (May 16-27 this year) Keep an eye out for Michael Moore’s new movie Sicko - it might just manage to sneak in in time: “This film... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=560380 Sun, 22 Apr 2007 09:13:10 +0100 560380 http://www.medworm.com/index.php?rid=554597&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F04%2F19%2Ffda-hearings-2006%2F I’ve been meaning to start this thread for a while now - last December (2006) the FDA held hearings into suicidality risks in adults (in connection with SSRIs). Documentary maker Phil Lawrence went along to film. Here’s his take of it: 2.20.2006 Trip to Washington DC Last week, we packed up the gear and headed to Washington for the FDA’s hearings to review the suicidality risks in adults. I’ll have to admit, at first, it was a little intimidating – I mean, this is the real deal – the FDA! So, we show up at the meeting room an hour or so early to get settled in and get the cameras set up – we sign in and were lucky enough to wedge ourselves in between the CNN and ABC News cameras. My heart was pounding – I was about to witness one of the processes that makes our coun... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=554597 Thu, 19 Apr 2007 19:08:17 +0100 554597 http://www.medworm.com/index.php?rid=551471&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F04%2F16%2Fthe-chemistry-of-happiness%2F Another slice of history - this from 2002, from Simon Garfield writing in the SocietyGuardian.co.uk It’s a long but very, very interesting article: Seroxat is set to overtake Prozac as the world’s favourite antidepressant. With 100m prescriptions in more than 100 countries, it is aggressively marketed as the addiction-free answer to our anxieties. But thousands of patients are now saying their dependence on the dream drug has all but destroyed their lives In September 1959, a gathering of many of the world’s leading psychiatrists met at Clare College, Cambridge, for a seminar on the treatment of depression. The timing was propitious; new drugs were just emerging from the shadow of tranquillisers such as diazepam (Valium) and chlorpromazine, and the ruthlessly effective ... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=551471 Mon, 16 Apr 2007 15:54:59 +0100 551471 http://www.medworm.com/index.php?rid=551473&cid=t_113167_140_f&fid=35436&url=http%3A%2F%2Fseroxatsecrets.wordpress.com%2F2007%2F04%2F14%2F1998-shy-try-taking-a-pill%2F Ah, all those years ago - life was so simple then, we were more innocent. The summers went on forever and our problems never really amounted to much. We believed what we were told - the drugs we took were tested and safe, all they did was to cure us and you couldn’t become addicted to Seroxat… and… what’s even better – it treats a whole range of other ‘conditions’: New pill to beat shyness Sunday Mirror, Oct 4, 1998 A PILL to combat shyness is being launched this week and will be available on the NHS. The drug, which could relieve the symptoms of up to three million chronically- shy people in Britain, is reported to improve the condition within a week in some cases. Seroxat, which was originally licensed to treat depression, has now been given the go-a... seroxat secrets... blogs http://www.medworm.com/rss/comments.php?id=551473 Sat, 14 Apr 2007 20:20:39 +0100 551473