MedWorm provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest medical blog items that have been tagged with 'h1n1 influenza'. Sat, 03 Sep 2011 02:05:45 +0100 http://www.medworm.com/index.php?rid=5051235&cid=t_278175_150_f&fid=35777&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FPharmalot%2F%7E3%2F0aGEPpZ3D4M%2F Several months after a curious link was observed between the GlaxoSmithKline pandemic flu vaccine known as Pandremix and unexplained cases of narcolepsy emerged in Finland and Sweden, the European Medicines Agency has decided to restrict usage. Specifically, those younger than 20 years old should use Pandemrix only in the absence of seasonal trivalent flu vaccines, and if immunization against H1N1 swine flu is still needed. An example would be those at risk of complications from infection, according to the EMA (read here). However, the EMA notes that, for now, the benefits continue to outweigh the risks. Over 31 million doses of Pandemrix have been administered worldwide in 47 countries, according to Glaxo. And a total of 335 cases of narcolepsy in people vaccinated with Pandemrix have bee... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=5051235 Fri, 22 Jul 2011 12:52:53 +0100 5051235 http://www.medworm.com/index.php?rid=4622345&cid=t_278175_113_f&fid=39278&url=http%3A%2F%2Fblogsite.mdbuyline.com%2F%3Fp%3D217 A highly sensitive laboratory test that uses gold nanoparticles caught my interest.  The need for accuracy has allowed DNA laboratory tests for genetics and infectious diseases to become the standard of care.  But, when it comes to infectious diseases, speed and ease of use can make a test much more valuable. Each year, over 12 million patients will seek emergency room treatment for flu symptoms.  These patients may spend hours in the ER and 200,000 will eventually be hospitalized.  One concern of respiratory viruses is pandemic influenza control.  Historical data shows that rapid tests used to detect outbreaks in institutions play an important role in controlling pandemic influenza. Researchers have developed the Verigene System, which uses DNA probes that coat the molecules of inter... MD Buyline blogs http://www.medworm.com/rss/comments.php?id=4622345 Tue, 22 Mar 2011 17:08:48 +0100 4622345 http://www.medworm.com/index.php?rid=4394518&cid=t_278175_107_f&fid=36672&url=http%3A%2F%2Fwww.sciencebase.com%2Fscience-blog%2Fscience-news-5.html Latest science news snippets from Sciencebase Bee team funded by Bayer – It is revealed that the lead investigator in the study that recently published results suggesting that bee colony collapse disorder (CCD) is due to the combined effect of a virus and a fungus is funded by the insecticide company (Bayer). The researcher denies that this funding is connected to the research, it pays for other work, but you can't help but wonder whether there is a conflict of interest here. Who’s your favourite scientist? – Who's your favourite scientist? For me it has to be Feynman, although Faraday would be a close second, oh and perhaps Sagan, and then there's Curie, and Kroto…oh the list goes on… Definition of a chemistry research paper – I've ... Sciencebase Science Blog blogs http://www.medworm.com/rss/comments.php?id=4394518 Mon, 17 Jan 2011 10:56:48 +0100 4394518 http://www.medworm.com/index.php?rid=4277636&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Fmedia.rawvoice.com%2Fpmn_twiv%2Ftraffic.libsyn.com%2Ftwiv%2FTWiV112.mp3 Hosts: Vincent Racaniello, Alan Dove, and Rich Condit On episode #112 of the podcast This Week in Virology, Vincent, Alan, and Rich review the making of a virulent poxvirus by insertion of the gene encoding IL-4, and severe 2009 H1N1 influenza due to pathogenic immune complexes. Download TWiV #112 (71 MB .mp3, 98 minutes). To download, right-click or control-click on the link, then select save as. Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio. Links for this episode: Expression of IL-4 makes a killer poxvirus Additional studies on poxvirus-IL-4 recombinants Creation of killer poxvirus could have been predicted Interleukin regulation of Th responses Severe pandemic H1N1 disease due to immune... virology blog blogs http://www.medworm.com/rss/comments.php?id=4277636 Sun, 19 Dec 2010 18:45:01 +0100 4277636 http://www.medworm.com/index.php?rid=4245011&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FVirologyBlog%2F%7E3%2FsoDQyobQdZg%2F Influenza researcher Peter Palese visited yesterday and spoke about “Pandemic influenza: Past and Future”. A key part of his talk was a review of his efforts to produce a universal influenza vaccine which protects against all strains. He used the following graph to make the point that when influenza pandemic strains emerge, there is insufficient time to deliver a vaccine using current technology. Image source: CIDRAP The graph depicts the percentage of visits for influenza-like illness (ILI – the red line) and distribution of the swine-origin influenza vaccine (blue line) from September 2009 to May 2010 in the US. At the peak of ILI at the end of October 2009, fewer than 20 million doses of vaccine had been shipped. By the time 120 million doses had been distributed, infe... virology blog blogs http://www.medworm.com/rss/comments.php?id=4245011 Thu, 09 Dec 2010 17:15:05 +0100 4245011 http://www.medworm.com/index.php?rid=3868624&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Fmedia.rawvoice.com%2Fpmn_twiv%2Fwww.twiv.tv%2FTWiV095.mp3 Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit On episode #95 of the podcast This Week in Virology, Vincent, Dickson, Alan, and Rich consider the end of the influenza H1N1 pandemic, dengue in Florida, vaccinia virus infection in Brazilian monkeys, and viruses in the faecal microbiota. Download TWiV #95 (68 MB .mp3, 94 minutes) Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio. Links for this episode: WHO declares end of influenza H1N1 pandemic CDC’s FluView WHO global monitoring of influenza Locally acquired dengue in Key West, Florida (MMWR) CDC page on dengue Vaccinia virus infection in monkeys of the Brazilian Amazon Dam site where animals were collected for... virology blog blogs http://www.medworm.com/rss/comments.php?id=3868624 Sun, 15 Aug 2010 23:40:44 +0100 3868624 http://www.medworm.com/index.php?rid=3724382&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Fmedia.rawvoice.com%2Fpmn_twiv%2Fwww.twiv.tv%2FTWiV089.mp3 Hosts: Vincent Racaniello and Alan Dove On episode #89 of the podcast This Week in Virology, Vincent and Alan review recent findings on the association of the retrovirus XMRV with ME/CFS, reassortment of 2009 pandemic H1N1 influenza virus in swine, and where influenza viruses travel in the off-season. Download TWiV #89 (56 MB .mp3, 78 minutes) Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio. Links for this episode: Conflicting XMRV papers on hold Leak of PNAS paper CDC study on XMRV in CFS patients (Retrovirology) and Science update Where influenza viruses travel in the off season (EurekaAlert! and PLoS Pathogens) NPR article on Ebola siRNA treatment (thanks, Andreas!) Priming mechanism for re... virology blog blogs http://www.medworm.com/rss/comments.php?id=3724382 Sun, 04 Jul 2010 17:03:57 +0100 3724382 http://www.medworm.com/index.php?rid=3706993&cid=t_278175_150_f&fid=35777&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FPharmalot%2F%7E3%2FNJj_HyWGF4o%2F In what may be a new get-tough program at the FDA, the agency issued a so-called untitled letter to CSL, a big maker of flu vaccines based in Australia, for flunking an April inspection that found several manufacturing deficiencies. And in addition to demanding a summary of corrective actions that must be taken, FDA officials want to meet with CSL senior execs to review their plan. The move comes less than a month after CSL recalled its seasonal shot for children in Australia after investigations failed to explain a nine-fold increase in fever and convulsions. However, the FDA also issued a Q&A in which the agency says the manufacting issues are unrelated to the problems that spurred the recall (background here and here). The FDA cited CSL for “a number of significant objectio... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=3706993 Mon, 28 Jun 2010 20:42:34 +0100 3706993 http://www.medworm.com/index.php?rid=3545416&cid=t_278175_87_f&fid=34935&url=http%3A%2F%2Fmedicine.com.my%2Fwp%2F%3Fp%3D8541 ILI (Influenza-like-illness) clusters continue to be reported Nine reports of influenza-like-illness (ILI) cluster cases were received by the Health Ministry from 8am Friday till 8am Saturday. The cases were reported to have occurred in Johor, Perak, Kelantan, Pahang, Negri Sembilan, Malacca and Penang. In Perak, one case was reported in Kampung Teluk Kepayang, while in Kelantan, two cases were reported at the Pasir Mas National Service Training Camp and SMK Gual Periok, Pasir Mas. Two cases were reported in Taman Skudai Baru, Johor Baru and the Tun Hussein Onn Teacher Training Institute in Batu Pahat. One case was reported each at SMK Kuala Repas Bentong, Pahang; SM Rendah Agama Repah, Negri Sembilan; Felda Kemendor Jasin, Malacca; and SJK Chin Shih Chung in Sungai Nibong, Penang. Health ... Malaysian Medical Resources blogs http://www.medworm.com/rss/comments.php?id=3545416 Fri, 07 May 2010 23:00:00 +0100 3545416 http://www.medworm.com/index.php?rid=3457791&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Fmedia.rawvoice.com%2Fpmn_twiv%2Fwww.twiv.tv%2FTWiV077.mp3 Hosts: Vincent Racaniello, Alan Dove, and Rich Condit Vincent, Alan, and Rich revisit circovirus contamination of Rotarix, then discuss poxvirus-like replication of mimivirus in the cell cytoplasm, and whether seasonal influenza immunization increases the risk of infection with the 2009 H1N1 pandemic virus. This episode is sponsored by Data Robotics Inc. Use the promotion code TWIVPOD to receive $50 off a Drobo or $100 off a Drobo S. Win a free Drobo S! Contest rules here. Download TWiV #77 (60 MB .mp3, 83 minutes) Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email. Links for this episode: Contamination of Rotarix vaccine with porcine circovirus 1 DNA Do you want to know what is in your vaccines? Take the poll Mimivirus replicates in the cell cytopl... virology blog blogs http://www.medworm.com/rss/comments.php?id=3457791 Sun, 11 Apr 2010 14:36:56 +0100 3457791 http://www.medworm.com/index.php?rid=3412411&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Fmedia.rawvoice.com%2Fpmn_twiv%2Fwww.twiv.tv%2FTWiV075.mp3 Hosts: Vincent Racaniello, Alan Dove, and Matthew Frieman Vincent, Alan, and Matt review contamination of Rotarix with circovirus DNA, antigenic similarity between 1918 and 2009 H1N1 influenza, a collection of rabies reports, and chicken pox mistaken for smallpox in Uganda. This episode is sponsored by Data Robotics Inc. Use the promotion code VINCENT to receive $50 off a Drobo or $100 off a Drobo S. Win a free Drobo S! Contest rules here. Download TWiV #75 (57 MB .mp3, 79 minutes) Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email. Links for this episode: Contamination of Rotarix vaccine with porcine circovirus 1 DNA Beak and feather disease circovirus (BFDV) threatens parrots Antigenic similarity between 1918 and 2009 H1N1 influenza Presumptive ab... virology blog blogs http://www.medworm.com/rss/comments.php?id=3412411 Sun, 28 Mar 2010 13:19:43 +0100 3412411 http://www.medworm.com/index.php?rid=3389160&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Fmedia.rawvoice.com%2Fpmn_twiv%2Fwww.twiv.tv%2FTWiV074.mp3 Hosts: Vincent Racaniello and Adolfo Garcia-Sastre Vincent speaks with Adolfo Garcia-Sastre talk about the origin, pathogenesis, and prevention of the 2009 pandemic influenza H1N1 virus. This episode is sponsored by Data Robotics Inc. Use the promotion code VINCENT to receive $50 off a Drobo or $100 off a Drobo S. Win a free Drobo S! Contest rules here. Download TWiV #74 (34 MB .mp3, 47 minutes) Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email. Links for this episode: Influenza virus receptor specificity and disease PB1-F2 expression by 2009 H1N1 strain does not increase virulence Protection against 2009 H1N1 infection by immunization with older strains Passage in eggs changes influenza receptor specificity Association between D222G mutation and v... virology blog blogs http://www.medworm.com/rss/comments.php?id=3389160 Mon, 22 Mar 2010 01:14:21 +0100 3389160 http://www.medworm.com/index.php?rid=3382426&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FVirologyBlog%2F%7E3%2FVZEtRry8oHQ%2F Last year a mutation in the HA gene of the 2009 H1N1 influenza virus was identified in isolates from patients with severe disease. At the time I concluded that the emergence of this change was not a concern. Recently the Norwegian Institute of Public Health reported that the mutation, which causes a change from the amino acid aspartic acid to glycine at position 225 of the viral HA protein (D225G), has been identified in 11 of 61 cases (18%) of severe or fatal influenza, but not in any of 205 mild cases. Have these observations changed my view of the importance of this mutation? The cell receptor for influenza A virus strains is sialic acid. Human influenza A strains bind preferentially to sialic acids linked to galactose by an alpha(2,6) bond, while avian and equine strains prefer alpha... virology blog blogs http://www.medworm.com/rss/comments.php?id=3382426 Fri, 19 Mar 2010 03:14:01 +0100 3382426 http://www.medworm.com/index.php?rid=3358616&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FVirologyBlog%2F%7E3%2Fd2XR0dpw4qY%2F The second RNA segment of some influenza virus strains encodes a protein called PB1-F2 that might contribute to virulence. Speaking about the 2009 pandemic H1N1 strain, Peter Palese noted that “If this virulence marker is necessary for an influenza virus to become highly pathogenic in humans or in chickens, then the current swine virus doesn’t have what it takes to become a major killer.” If the pandemic virus mutated so that the PB1-F2 protein is produced, would it become a killer? The PB1-F2 protein is not produced in cells infected with the 2009 H1N1 strain because there are three translation stop codons at nucleotide positions 12, 58, and 88.  To determine if this protein plays a role in virulence, the second RNA segment of the A/California/04/2009 H1N1 strain was genetically al... virology blog blogs http://www.medworm.com/rss/comments.php?id=3358616 Fri, 12 Mar 2010 13:32:15 +0100 3358616 http://www.medworm.com/index.php?rid=3354022&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FVirologyBlog%2F%7E3%2FpMBTGgqc1RQ%2F The World Health Organization and the US Food & Drug Administration have decided on the composition of the influenza virus vaccine that will be used during the 2010-2011 season in the northern hemisphere. The trivalent preparation will contain the following influenza virus strains: A/California/7/2009 (H1N1); A/Perth/16/2009 (H3N2); and B/Brisbane/60/2008. The same trivalent vaccine is also being used to prepare for the upcoming winter in the southern hemisphere. The A/California/7/2009 (H1N1) virus is the pandemic strain that was used in the 2009 H1N1 monovalent vaccine. That virus has not yet undergone sufficient antigenic drift to warrant selection of a new strain for the vaccine. Note that a seasonal H1N1 strain from previous years will not be included in the vaccine. This chang... virology blog blogs http://www.medworm.com/rss/comments.php?id=3354022 Wed, 10 Mar 2010 23:10:31 +0100 3354022 http://www.medworm.com/index.php?rid=3318122&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Fmedia.rawvoice.com%2Fpmn_twiv%2Fwww.twiv.tv%2FTWiV071.mp3 Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit Vincent, Dickson, Alan, and Rich answer listener questions about maternal infection and fetal injury, viral gene therapy, eyeglasses and influenza, filtering prions from blood, eradication of rinderpest, Tamiflu resistance of H1N1 influenza, bacteriophages and the human microbiome, H1N1 vaccine recalls, human tumor viruses, RNA interference, and junk DNA. This episode is sponsored by Data Robotics Inc. Use the promotion code VINCENT to receive $50 off a Drobo or $100 off a Drobo S. Win a free Drobo S! Contest rules here. Download TWiV #71 (63 MB .mp3, 88 minutes) Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email. Links for this episode: Maternal infection and fetal neurologic... virology blog blogs http://www.medworm.com/rss/comments.php?id=3318122 Mon, 01 Mar 2010 01:00:22 +0100 3318122 http://www.medworm.com/index.php?rid=3269742&cid=t_278175_111_f&fid=36048&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FAHeartyLife%2F%7E3%2Fir7ymCdys2Y%2F The H1N1 virus, the so-called swine flu, hit 57 million Americans and was the cause of 257,000 hospitalizations and 11,690 deaths in the United States. Fifty seven million: that’s more than the population of Spain (46 million) and Canada (34 million). The number of people hospitalized because of the H1N1 influenza is just slightly more than the entire population of Barbados, or equal to half the state of Wyoming. That’s a lot of people. The flu is still around and vaccines are still being given. The US winter Olympic athletes were vaccinated last month if they’d not already been, giving the vaccine enough time to be effective when the 2010 Vancouver Winter Olympics begin tonight. What was it about the H1N1 flu that got the world so concerned and should it have been? It&#8... A Hearty Life blogs http://www.medworm.com/rss/comments.php?id=3269742 Fri, 12 Feb 2010 20:36:00 +0100 3269742 http://www.medworm.com/index.php?rid=3266701&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FVirologyBlog%2F%7E3%2FNzr5kGw2Wnw%2F Influenza A viruses typically cause severe respiratory disease mainly in the very young or the elderly. The 2009 swine-origin H1N1 virus is unusual because it preferentially infects individuals under 35 years of age. We’ve previously noted that being older is a good defense against 2009 H1N1 influenza virus, in part because older people have antibodies that block infection. Experiments done in mice show that immunization with 1918-like or classical H1N1 swine influenza viruses protects against infection with 2009 H1N1 virus. When mice are inoculated intranasally with a high dose of the 2009 H1N1 influenza virus, the virus replicates in the lungs and leads to significant weight loss and lethality. After a sublethal virus dose the mice develop protective antibodies that protect agains... virology blog blogs http://www.medworm.com/rss/comments.php?id=3266701 Thu, 11 Feb 2010 20:17:26 +0100 3266701 http://www.medworm.com/index.php?rid=3250975&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Fmedia.rawvoice.com%2Fpmn_twiv%2Fwww.twiv.tv%2FTWiV069.mp3 Hosts: Vincent Racaniello, Alan Dove, and Rich Condit Vincent, Alan, and Rich review recent outbreaks of mumps in the UK, US, and Israel, protection of mice against 2009 H1N1 influenza A virus by 1918-like and classical swine H1N1 vaccines, and a virus-like particle vaccine for chikungunya virus. This episode is sponsored by Data Robotics Inc. Use the promotion code VINCENT to receive $50 off a Drobo or $100 off a Drobo S. Win a free Drobo S! Contest rules here. Download TWiV #69 (59 MB .mp3, 82 minutes) Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email. Links for this episode: Mumps outbreak in Israel (ProMedMail and Eurosurveillance; thanks Lenn!) and Iowa Retraction of Wakefield vaccines- autism study Immunization with 1918-like and classical sw... virology blog blogs http://www.medworm.com/rss/comments.php?id=3250975 Mon, 08 Feb 2010 03:22:28 +0100 3250975 http://www.medworm.com/index.php?rid=3180284&cid=t_278175_111_f&fid=36048&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FAHeartyLife%2F%7E3%2F_1vREUgzj7k%2F Although the H1N1 virus has faded quite a bit in the news, it is still active throughout the world, including the United States. The World Health Organization (WHO) reports that as of January 10, 2010, “more than 208 countries and overseas territories or communities have reported laboratory confirmed cases of pandemic influenza H1N1 2009, including at least 13,554 deaths.” The most active regions right now remain parts of North Africa, South Asia and the eastern and southeastern areas of Europe. North Africa The virus is still spreading in countries such as Morocco, Algeria and Egypt. South Asia Countries in South Asia that are reporting active infection spread of H1N1 include Nepal, India (more in the west, less so in the north), and Sri Lanka – although the virus may be... A Hearty Life blogs http://www.medworm.com/rss/comments.php?id=3180284 Sun, 17 Jan 2010 15:44:26 +0100 3180284 http://www.medworm.com/index.php?rid=3175595&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Fwww.radiosandysprings.com%2Fpodcasts%2FInfectiousDiseaseJan04.2010.mp3 I was recently interviewed on Radio Sandy Springs by Sharon Sanders of FluTrackers. We talked about pandemic influenza H1N1 virus. Listen to the show below. Download Infectious Disease Hour January 4 2010 (20 MB .mp3, 57 minutes) Radio Sandy Springs 1620 AM is a low-powered Atlanta-based talk radio station that simulcasts on the Internet.  They broadcast a weekly ‘Infectious Disease Update’ with interviews with clinicians, scientists, researchers, and even historians. You can find an archive of recent Infectious Disease Hour shows here. (Source: virology blog) virology blog blogs http://www.medworm.com/rss/comments.php?id=3175595 Thu, 14 Jan 2010 22:00:33 +0100 3175595 http://www.medworm.com/index.php?rid=3126477&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FVirologyBlog%2F%7E3%2F9F6kjjjpdzY%2F In healthy individuals, the first encounter with a virus leads to a primary antibody response. When an infection occurs with the same or a similar virus, a rapid antibody response occurs that is called the secondary antibody response. Antibodies are critical for preventing many viral infections, including influenza. But reinfection may occur if we encounter the same virus before the primary response is complete. Recently three cases of confirmed infection with 2009 influenza H1N1 were reported in Chile. The first patient had laboratory confirmed infection; treatment with oseltamivir resolved symptoms after 48 hours. Twenty days later the patient developed a second bout of laboratory confirmed influenza which was treated with amantadine. The second patient acquired laboratory confirmed i... virology blog blogs http://www.medworm.com/rss/comments.php?id=3126477 Mon, 28 Dec 2009 21:09:44 +0100 3126477 http://www.medworm.com/index.php?rid=3104978&cid=t_278175_86_f&fid=38272&url=http%3A%2F%2Flaikaspoetnik.wordpress.com%2F2009%2F12%2F18%2Foverproduction-of-th1-and-th17-cytokines-may-be-the-clue-to-why-some-h1n1-patients-get-very-ill%2F The present H1N1 influenza virus (nvH1N1, nv=new variant) behaves very differently from other influenza strains. The majority of nvH1N1 infections are mild and self-limiting in nature, but a small percentage of the patients require hospitalization and sometimes emergency care. Unlike the seasonal flu virus, the people who seem to suffer serious complications from this [...] (Source: Laika's MedLibLog) Laika's MedLibLog blogs http://www.medworm.com/rss/comments.php?id=3104978 Fri, 18 Dec 2009 22:15:30 +0100 3104978 http://www.medworm.com/index.php?rid=3092651&cid=t_278175_86_f&fid=38272&url=http%3A%2F%2Flaikaspoetnik.wordpress.com%2F2009%2F12%2F16%2Fnot-one-rct-on-swine-flu-or-h1n1-outrageous%2F Last week doctorblogs (Annabel Bentley) tweeted: “Outrageous- there isn’t ONE randomised trial on swine flu or #H1N1“ Annabel referred to an article at Trust the Evidence, the excellent blog of the Centre for Evidence-Based Medicine (CEBM) in Oxford, UK. In the article “Is swine flu the most over-published and over-hyped disease ever?” Carl Heneghan first showed [...] (Source: Laika's MedLibLog) Laika's MedLibLog blogs http://www.medworm.com/rss/comments.php?id=3092651 Wed, 16 Dec 2009 10:46:49 +0100 3092651 http://www.medworm.com/index.php?rid=3078960&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FVirologyBlog%2F%7E3%2FjEBJUSa75y0%2F Before the development of cell culture, many viruses were propagated in embryonated chicken eggs. Today this method is most commonly used for growth of influenza virus. The excellent yield of virus from chicken eggs has led to their widespread use in research laboratories and for vaccine production. In fact the vast majority of influenza vaccines – both inactivated and infectious – are produced in chicken eggs. How is influenza virus propagated in eggs? The illustration below shows a cutaway view of an embryonated chicken egg. The different routes of inoculation into the egg are shown, as well as the different compartments in which viruses replicate. For propagation of influenza virus, pathogen-free eggs are used 11-12 days after fertilization. The egg is placed in front of a ... virology blog blogs http://www.medworm.com/rss/comments.php?id=3078960 Thu, 10 Dec 2009 20:51:51 +0100 3078960 http://www.medworm.com/index.php?rid=3066736&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FVirologyBlog%2F%7E3%2Fmi1H3VMeQDU%2F If you have been reading this blog you know I believe that those who write about viruses must always make sure that they get the science right. I’m always on the lookout for violations. Are there any problems with the plush toys produced by Giant Microbes? I came across the influenza plush toy in my desk this weekend. The color – green – and the two eyes are gratuitous additions that have nothing to do with reality. Of course, virus particles are too small to have color, but a colorless – or eyeless – toy line would have little appeal to children. What about that elongated shape? Influenza virions are pleomorphic; they are generally spherical, but filamentous particles are often observed in fresh clinical isolates. So the shape is acceptable. But the soft velv... virology blog blogs http://www.medworm.com/rss/comments.php?id=3066736 Mon, 07 Dec 2009 22:19:43 +0100 3066736 http://www.medworm.com/index.php?rid=3063327&cid=t_278175_111_f&fid=36048&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FAHeartyLife%2F%7E3%2FOItBagnTUMw%2F Influenza is still in the news, be it H1N1 or the seasonal flu. But even when the flu isn’t newsworthy, we still need to be aware of it, particularly over the winter season. With the holiday season quickly taking hold, I interviewed, Payam Hakimi, D.O., American Board of Family Physicians, Medical Director Body of Harmony Institute of Health & Healing, Teaching Faculty Center for Education & Development of Clinical Homeopathy. Dr. Hakimi suggests that everyone have a flu plan, allowing them to be prepared should they be hit with influenza, whatever type. Dr. Hakimi: The most important thing a person should know is what actions to take in case they have the signs and symptoms of the flu, which are outlined below.  It is important to know that most of these signs and symptoms ... A Hearty Life blogs http://www.medworm.com/rss/comments.php?id=3063327 Mon, 07 Dec 2009 12:03:29 +0100 3063327 http://www.medworm.com/index.php?rid=3061372&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Fmedia.rawvoice.com%2Fpmn_twiv%2Fwww.twiv.tv%2FTWiV061.mp3 Hosts: Vincent Racaniello and Dickson Despommier On episode 61 of the podcast “This Week in Virology”, Vincent and Dick muse about the symbiotic bacterium, Wolbachia, that protects flies from viral infection, the origin of 2009 influenza H1N1 virus, and the lure of original antigenic sin. Download TWiV #61 (45 MB .mp3, 62 minutes) Subscribe to TWiV in iTunes, by the RSS feed, or by email Links for this episode: Variation in antiviral protection mediated by different Wolbachia strains in Drosophila simulans Wolbachia induces resistance to RNA virus infections in Drosophila Wolbachia reduces blood-feeding success in Dengue mosquito Did 2009 H1N1 influenza come from a laboratory? Influenza original antigenic sin in mice but not in humans Dengue outbreak in Mexico (thanks Swiss co... virology blog blogs http://www.medworm.com/rss/comments.php?id=3061372 Sun, 06 Dec 2009 14:35:07 +0100 3061372 http://www.medworm.com/index.php?rid=3047871&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FVirologyBlog%2F%7E3%2FfPQVRzxWswg%2F The New York Times has published an editorial entitled “The Swine Flu, as of Now” which presents their views of the current influenza pandemic. The piece covers the number of infections, hospitalizations, and deaths; the distribution of vaccines, and lists those most at risk for severe disease. It begins with a positive view: So far, the news about swine flu is better than expected. The pandemic may have reached its peak and is heading downward in all regions of the country; weekly deaths from the swine flu have started to decline; the virus remains relatively mild; there seem to be few claims of serious side effects from the vaccine; and despite widespread complaints about shortages, vaccine supplies are steadily building up. The wording suggests that the pandemic is over, but... virology blog blogs http://www.medworm.com/rss/comments.php?id=3047871 Tue, 01 Dec 2009 22:25:35 +0100 3047871 http://www.medworm.com/index.php?rid=3039732&cid=t_278175_86_f&fid=36669&url=http%3A%2F%2Ffadelibrary.wordpress.com%2F2009%2F11%2F30%2Fswine-flu-and-rough-sleepers-for-organisations-working-with-rough-sleepers-in-england%2F Title: Information for organisations working with rough sleepers in England Skinny: Information prepared for those who are working with or providing services for rough sleepers during the swine flu pandemic.  It provides advice on how to support rough sleepers and signposts to guidance and other useful sources. Publisher: DH Size of Publication: 5p Published: 25/11/2009 Posted in Grey Literature, Homelessness, NHS, Voluntary Sector Tagged: Grey Literature, H1N1, Homelessness, Influenza, NHS, Pandemic, Voluntary Sector (Source: Fade Library) Fade Library blogs http://www.medworm.com/rss/comments.php?id=3039732 Mon, 30 Nov 2009 15:29:06 +0100 3039732 http://www.medworm.com/index.php?rid=3022728&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FVirologyBlog%2F%7E3%2FR2_2kJHRwx0%2F The Norwegian Institute of Public Health recently identified a mutation in 2009 H1N1 influenza virus isolated from two patients who died and one with severe disease. It has been suggested that this mutation, which causes a change from the amino acid aspartic acid to glycine at position 225 of the viral HA protein (D225G), could make the virus more likely to infect deeper in the airways and cause more severe disease. What is the basis for this concern and does it have merit? Attachment of all influenza A virus strains to cells requires sialic acids. There are a number of chemically different forms of sialic acids, and influenza virus strains vary in their affinity for them. Human influenza A strains bind preferentially to sialic acids linked to galactose by an alpha(2,6) bond, while avian a... virology blog blogs http://www.medworm.com/rss/comments.php?id=3022728 Tue, 24 Nov 2009 16:57:49 +0100 3022728 http://www.medworm.com/index.php?rid=3016915&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Fmedia.rawvoice.com%2Fpmn_twiv%2Fwww.twiv.tv%2FTWiV059.mp3 Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Gustavo Palacios, and Mady Hornig A TWiV panel of five considers the finding of Streptococcus pneumoniae in fatal H1N1 cases in Argentina, hysteria in the Ukraine over pandemic influenza, and human vaccinia infection after contact with a raccoon rabies vaccine bait. Download TWiV #59 (58 MB .mp3, 80 minutes) Subscribe to TWiV in iTunes, by the RSS feed, or by email Links for this episode: Argentine flu death mystery H1N1 influenza outbreak in Ukraine (article one and two, and WHO statement) Human vaccinia infection after contact with rabies vaccine bait Agrippal S1 inactivated H1N1 vaccine (pdf – thanks Ariel and Ayelet) Nick’s letter on are viruses and life Take the poll: are viruses alive? Weekly Science Picks Rich Longitu... virology blog blogs http://www.medworm.com/rss/comments.php?id=3016915 Sun, 22 Nov 2009 14:45:28 +0100 3016915 http://www.medworm.com/index.php?rid=3016916&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FVirologyBlog%2F%7E3%2FKbH818sflWc%2F As week 46 of 2009 comes to a close, the Centers for Disease Control and Prevention reports that influenza has peaked in the US. That conclusion is based on the agency’s influenza surveillance program, summarized in this figure: Does this mean that pandemic influenza is over? Absolutely not. This is just the second wave, sparked when school began in the fall. Recall the the first wave of H1N1 infections that took place during the spring and summer: It’s interesting to note that seasonal H1N1 and H3N2 strains are nearly gone. Of the 10,803 specimens tested by the CDC during week 45, 3,106 were confirmed as novel H1N1, one was seasonal H1N1, and no H3N2 strain was detected. There will be more influenza to come in the winter. A catalyst might be increased travel as we come upon... virology blog blogs http://www.medworm.com/rss/comments.php?id=3016916 Fri, 20 Nov 2009 22:01:14 +0100 3016916 http://www.medworm.com/index.php?rid=3012458&cid=t_278175_111_f&fid=36048&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FAHeartyLife%2F%7E3%2FPDbm2kwjI2w%2F Children who have asthma are at higher risk of developing problems if they contract the H1N1 flu, more so than if they have the seasonal flu, say researchers. Researchers in Toronto, Canada, investigated the differences between 58 children with H1N1 who were admitted to the Hospital for the Hospital for Sick Kids, in Toronto, and 200 who had been admitted to the same hospital with complications from the seasonal flu, between 2004 and 2008. The researchers found that 22% of the children who were admitted because of H1N1 had asthma, while only 6% of those with seasonal influenza were asthmatic. In addition, about 50% of those children with H1N1 who had to be admitted to the intensive care unit had asthma (study). Other differences included: Older children were admitted with H1N1 than with t... A Hearty Life blogs http://www.medworm.com/rss/comments.php?id=3012458 Thu, 19 Nov 2009 23:37:45 +0100 3012458 http://www.medworm.com/index.php?rid=3016918&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FVirologyBlog%2F%7E3%2FUuO7_bq9S78%2F A number of readers have asked when we would have information about the safety of the influenza 2009 H1N1 vaccine. The World Health Organization has just released briefing note #16 “Safety of pandemic vaccines” in which they summarize vaccination information from 16 countries in which 80 million doses of vaccine have been administered. Side effects commonly reported include swelling, redness, or pain at the injection site, which usually resolve soon after vaccination. Fever, headache, fatigue, muscle aches, and a variety of allergic reactions, occurring shortly after vaccine administration, have also been reported less frequently. There have been fewer than ten cases of Guillain-Barre syndrome reported in H1N1 vaccine recipients. These numbers are consistent with normal backgro... virology blog blogs http://www.medworm.com/rss/comments.php?id=3016918 Thu, 19 Nov 2009 16:22:20 +0100 3016918 http://www.medworm.com/index.php?rid=3016919&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FVirologyBlog%2F%7E3%2F_cPMuuWH1d0%2F Although the influenza 2009 H1N1 vaccine produced by Novartis, Fluvirin, was previously approved for use in the US, the clinical data supporting its safety and immunogenicity had not been released. The company has now issued a media release containing interim clinical data on the effects of the vaccine in humans. According to the company, testing of the vaccine in 4,080 adult and elderly (>65 years) US individuals has revealed that a half dose (3.75 micrograms) without adjuvant “fulfilled immune response criteria associated with protection”. I assume that the latter statement means that hemagglutination inhibition titers of 1:40 or greater were observed, but this is not explicitly stated.  Current US guidelines for the 2009 H1N1 2009 vaccine stipulate that adolescents, adul... virology blog blogs http://www.medworm.com/rss/comments.php?id=3016919 Wed, 18 Nov 2009 22:08:19 +0100 3016919 http://www.medworm.com/index.php?rid=2995529&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Fmedia.rawvoice.com%2Fpmn_twiv%2Fwww.twiv.tv%2FTWiV058.mp3 Hosts: Vincent Racaniello, Dick Despommier, Alan Dove, and Joshua Stillman In episode 58 of the podcast “This Week in Virology”, Vincent, Dick, and Alan are joined by emergency medicine physician Dr. Joshua Stillman to talk about passive antibody therapy for Nipah infection in ferrets, annual influenza immunization of children, facemasks to prevent influenza, predicting dengue outbreaks by the weather, and the amazing viral communities in an icy Antarctic lake. Download TWiV #58 (52 MB .mp3, 73 minutes) Subscribe to TWiV in iTunes, by the RSS feed, or by email Links for this episode: Post-exposure passive antibody therapy for Nipah virus in ferret Image above left shows Nipah viral antigen (red) in ferret brain ependymal epithelium Is yearly influenza vaccination of children ... virology blog blogs http://www.medworm.com/rss/comments.php?id=2995529 Mon, 16 Nov 2009 13:55:11 +0100 2995529 http://www.medworm.com/index.php?rid=3016923&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FVirologyBlog%2F%7E3%2F5Tc0pJIJEx4%2F We’ve made no secret of our enthusiasm for the vaccine against the 2009 H1N1 influenza virus. To help you find locations near you for obtaining both the seasonal and 2009 H1N1 influenza vaccine, Google has developed a feature for the US called the flu shot finder at www.google.com/flushot. Google notes on their blog that this project is just beginning and information has not yet been received about flu shot clinics for many locations. Many locations that are shown are also out of stock. Google has been working with HHS, the Centers for Disease Control and Prevention (CDC) and state and local health agencies to gather information on flu vaccine locations across the country for both the nasal-spray vaccine and the inactivated vaccine shot. Data for locations of flu vaccine are currentl... virology blog blogs http://www.medworm.com/rss/comments.php?id=3016923 Fri, 13 Nov 2009 21:24:37 +0100 3016923 http://www.medworm.com/index.php?rid=2944026&cid=t_278175_136_f&fid=35302&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FWhitePebble%2F%7E3%2FYr3GbwuuS7Y%2F I have decided that Fall is most definitely here when I’ve gotten flu vaccinations, which I did last week and yesterday. Tracked down so far: regular flu shot pneumonia vaccine So far, no H1N1 has shown up on my personal health radar. The Health Department was offering 1500 or so of them, but one evidently had to stand for a couple of hours in the rain to get one. It was on the other side of town, too. So now my body is busy building antibodies, leaving me too sluggish to do much more than read blogs now. Technorati Tags: flu, health, Influenza A virus subtype H1N1, Influenza vaccine (Source: white pebble) white pebble blogs http://www.medworm.com/rss/comments.php?id=2944026 Fri, 30 Oct 2009 13:21:28 +0100 2944026 http://www.medworm.com/index.php?rid=2934431&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Fwww.quackcast.com%2Fspodcasts%2Ffiles%2Fpodcast_34.mp3 My interminable 2.5 hour commute this morning was made tolerable by listening to the Quackcast #35 from Mark Crislip, “Flu vaccine efficacy and 18 taradiddles”. In this excellent and highly recommended episode, Dr. Crislip addresses the contention that the influenza virus vaccine is worthless. To make it even easier for you to listen to this episode, I’ve embedded the podcast in this post, so you just have to click on the audio player below. I do have one criticism: Dr. Crislip uses the term antibiotics to describe drugs that inhibit viral replication. I recognize that Mark is aware of the proper name for antiviral drugs. To enable meaningful discussions, everyone should know that the terms antibiotic and antiviral have very different meaning. (Source: virology blog) virology blog blogs http://www.medworm.com/rss/comments.php?id=2934431 Tue, 27 Oct 2009 16:17:40 +0100 2934431 http://www.medworm.com/index.php?rid=3016930&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FVirologyBlog%2F%7E3%2FzJw2Mq96CBs%2F Earlier this year an influenza virus animation spread on YouTube just after the emergence of swine-origin influenza H1N1. I invited readers to criticise the animation which contained several errors. A much better depiction of influenza virus animation has been created by XVIVO. It’s not only more beautifully rendered, but is scientifically much more accurate. A slightly different version of the same video can be found at npr.org, but I prefer the video at XVIVO. The main problem is that NPR has added voice-over by Robert Krulwich.  I find his narration annoying – he seems to be speaking down to the viewer, and he simplifies viral replication to the extent that what really occurs is obscured. For example, after the influenza virion is taken into the cell by endocytosis, Krulwic... virology blog blogs http://www.medworm.com/rss/comments.php?id=3016930 Mon, 26 Oct 2009 21:06:24 +0100 3016930 http://www.medworm.com/index.php?rid=2927103&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Fmedia.rawvoice.com%2Fpmn_twiv%2Fwww.twiv.tv%2FTWiV055.mp3 Hosts: Vincent Racaniello, Dick Despommier, Alan Dove, Jason Rodriguez, and Rich Condit In episode 55 of the podcast “This Week in Virology”, the largest TWiV panel ever assembled takes on XMRV and chronic fatigue syndrome, 2009 chemistry Nobel prizes for ribosome structure, finding new poxvirus vaccine candidates, a brouhaha over leaked Canadian data on influenza susceptibility, and transmission of H1N1 influenza to a pet ferret. Download TWiV #55 (66 MB .mp3, 91 minutes) Subscribe to TWiV in iTunes, by the RSS feed, or by email Links for this episode: XMRV and chronic fatigue syndrome XMRV not found in German prostate cancer 2009 Chemistry Nobel Prize for ribosome structure New poxvirus vaccines (e! Science and Virology articles – thanks Jim!) Seasonal flu shots and ... virology blog blogs http://www.medworm.com/rss/comments.php?id=2927103 Sun, 25 Oct 2009 19:49:07 +0100 2927103 http://www.medworm.com/index.php?rid=2924884&cid=t_278175_111_f&fid=36048&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FAHeartyLife%2F%7E3%2FECvAfey4NnU%2F According to news reports, President Barack Obama has declared an H1N1 emergency in the United States. This move was declared earlier today. By making this declaration, medical resources can be distributed as they are needed, including off-site in non-traditional methods of delivery. There are still people who feel that the H1N1 influenza is being blown out of proportion and this will be the biggest non-event in history, but let’s look at the facts: Flu season, which runs from November until March, kills many people every year. Flu season hasn’t even really officially begun yet, and yet, the U.S. has seen 22 deaths directly attributed to H1N1, as reported by the Centers of Disease Control: 2009 – 2010  22 (18 confirmed H1N1)** 2008-2009  147 (76 confirmed H1N1)* 2007-2... A Hearty Life blogs http://www.medworm.com/rss/comments.php?id=2924884 Sun, 25 Oct 2009 00:22:16 +0100 2924884 http://www.medworm.com/index.php?rid=2923440&cid=t_278175_136_f&fid=39016&url=http%3A%2F%2Fturquoisegates.blogspot.com%2F2009%2F10%2Feven-though-i-walk-through-valley-of.html Even though I walk through the valley of the shadow of deathYour perfect love is casting out fearAnd even when I’m caught in the middle of the storms of this lifeI won’t turn backI know You are nearAnd I can see a light that is coming for the heart that holds onA glorious light beyond all compareAnd there will be an end to these troublesBut until that day comesWe’ll live to know You here on the earth~ You Never Let Go, Matt Redman ~The long trial seems to be over. For the moment, at least! I feel like I lost all of September and October to sickness. Amelia started eating yesterday evening, and her energy is improving every time she takes a bite. She is still running a bit of a fever today, and took 3 naps instead of her usual 1, but she is markedly better. Which is great...we were on... Turquoise Gates blogs http://www.medworm.com/rss/comments.php?id=2923440 Fri, 23 Oct 2009 21:48:00 +0100 2923440 http://www.medworm.com/index.php?rid=3016933&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FVirologyBlog%2F%7E3%2FnP-2UGV1rsc%2F The influenza A (H1N1) 2009 vaccine produced by GlaxoSmithKline has been approved by Canada Health. Here is some information on the vaccine to supplement what I’ve provided about the US counterparts. The Canadian vaccine, called Arepanrix H1N1, is supplied in two parts. One contains inactivated H1N1 influenza virus, and the second consists of AS03 adjuvant (DL-a-tocopherol, squalene, polysorbate 80). Before injection the virus and adjuvant are mixed. The vaccine is provided in 10-dose vials and therefore contains thimerosal. More information on the amounts of these components can be found at the Canada Health website (”Product Information Leaflet Arepanrix™ H1N1 AS03-Adjuvanted H1N1 Pandemic Influenza Vaccine”). Health Canada approved the vaccine based on limited clinic... virology blog blogs http://www.medworm.com/rss/comments.php?id=3016933 Thu, 22 Oct 2009 21:51:19 +0100 3016933 http://www.medworm.com/index.php?rid=3016934&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FVirologyBlog%2F%7E3%2FPvi3vGFCJRI%2F The World Health Organization recently convened a meeting of 100 clinicians, scientists, and public health professionals to discuss the clinical features of pandemic influenza. They concluded that the vast majority of infections with the 2009 H1N1 influenza virus were uncomplicated and are followed by full recovery within 7 days. However, some patients, including children, develop severe, progressive fatal pneumonia. Should we be worried about this pattern of infection? According to WHO: Concern is now focused on the clinical course and management of small subsets of patients who rapidly develop very severe progressive pneumonia. Treatment of these patients is difficult and demanding, strongly suggesting that emergency rooms and intensive care units will experience the heaviest burden of ... virology blog blogs http://www.medworm.com/rss/comments.php?id=3016934 Wed, 21 Oct 2009 12:00:09 +0100 3016934 http://www.medworm.com/index.php?rid=2908890&cid=t_278175_150_f&fid=35777&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FPharmalot%2F%7E3%2FTPkL0fYh15w%2F The ongoing debate over vaccines is, not surprisingly, extended to swine flu now that a pandemic has been declared and, as The Atlantic points out, the US government has mounted its most ambitious vaccination program since the anti-polio campaign in the 1950s. Five companies, you may recall, were commissioned to produce enough vaccine to cover the entire US population. The mag also reminds us that the CDC has recommended 159 million adults and children receive either a swine flu shot or a dose of MedImmune’s nasal vaccine this year. Shots are offered in doctors’ offices, hospitals, airports, pharmacies, schools, polling places, shopping malls, and big-box stores like Wal-Mart. And the federal government has spent upwards of $3 billion stockpiling millions of doses of antiviral drugs l... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=2908890 Tue, 20 Oct 2009 12:07:18 +0100 2908890 http://www.medworm.com/index.php?rid=3016935&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FVirologyBlog%2F%7E3%2FaU1wBkg6Y00%2F There have been many interesting responses to my recent post, “Are you receiving the influenza 2009 H1N1 vaccine?” Some individuals have already been immunized or plan to do so shortly. Others are concerned about the safety and efficacy of the monovalent preparations. As pointed out recently in a Nature editorial, “Mass-vaccination campaigns…must take public concerns into account”, and “officials should focus on providing people with the information they need to make good choices for themselves.” Here are some facts about the influenza H1N1 vaccine for those who haven’t yet made up their minds whether or not to be immunized. Four companies are licensed to produce the 2009 H1N1 influenza vaccine for the US – CSL Limited, Novartis Vaccine... virology blog blogs http://www.medworm.com/rss/comments.php?id=3016935 Tue, 20 Oct 2009 12:00:39 +0100 3016935 http://www.medworm.com/index.php?rid=2904582&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Fmedia.rawvoice.com%2Fpmn_twiv%2Fwww.virology.ws%2Fsciencepodcasters-flu.mp3 Because of concerns about the safety and efficacy of the new vaccine against 2009 H1N1 influenza (”swine flu”) Marc Pelletier, PhD from Futures in Biotech and I teamed up to record a public service announcement to encourage vaccination. This announcement addresses safety and side effects, which are expected to be similar to those from any influenza vaccine. Ginger Campbell MD, an emergency room physician, and host of Brain Science Podcast and Sciencepodcasters.org, was kind enough to add her recommendations to the announcement. I encourage you to listen the the announcement and share it with others. You are welcome to place it on websites, blogs, and podcasts. A copy of the mp3 file can be downloaded here. (Source: virology blog) virology blog blogs http://www.medworm.com/rss/comments.php?id=2904582 Sun, 18 Oct 2009 01:08:59 +0100 2904582 http://www.medworm.com/index.php?rid=2876168&cid=t_278175_115_f&fid=34670&url=http%3A%2F%2Fsumerdoc.blogspot.com%2F2009%2F10%2Ffatal-swine-flu-radiology.html According to the latest article in AJR 2009; 193:1–4 In severe or potentially fatal cases radiography shows peripheral lung opacities. CT revealed peripheral ground-glass opacities suggesting peribronchial injury in severe cases of the same. Full text is available.From Sumer's Radiology Site http://www.sumerdoc.blogspot.com -The Top Radiology Magazine. Teleradiology Providers at www.teleradproviders.com Mail us at teleradproviders@gmail.com (Source: Sumer's Radiology Site) Sumer's Radiology Site blogs http://www.medworm.com/rss/comments.php?id=2876168 Fri, 09 Oct 2009 01:49:00 +0100 2876168 http://www.medworm.com/index.php?rid=3016944&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FVirologyBlog%2F%7E3%2FafvRoDBub9M%2F During the more than 30 years that I have studied viruses, I have had many opportunities to speak with journalists of different kinds. For the most part, the print journalists have done a good job at accurately presenting the science, but I cannot say the same for my experience on radio and TV. I want to share some of these recordings and my thoughts about the gap between science and broadcast journalism. I was interviewed by Katy Pilgrim of CNN in May 2009, shortly after the emergence of swine-origin influenza H1N1. There had been a number of cases in New York City and Ms. Pilgrim was looking for comments on school closings. She came to my laboratory with a cameraman, spent 10 minutes talking with me off-camera followed by 10 minutes on-camera. As you will see in the news clip below that ... virology blog blogs http://www.medworm.com/rss/comments.php?id=3016944 Tue, 29 Sep 2009 20:19:55 +0100 3016944 http://www.medworm.com/index.php?rid=2851969&cid=t_278175_131_f&fid=34989&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FGeneticsHealth%2F%7E3%2FPiFMx9Tdeck%2F Countries all over the world are taking serious steps to stop the swine flu pandemic. China began its mass vaccination last week. And by October 5, the United States will distribute the first wave of swine flu vaccines, good for 6 million to million people. But the swiftness of government health agencies and the World Health Organization to address this issue is evidence about how rapid the H1N1 influenza virus has spread. It bears repeating that we need to take precautions in protecting ourselves and our families against the H1N1. What symptoms do you look for in swine flu? The symptoms of swine flu are similar to regular season flu, so report to your doctor if you have any symptoms. You will not know just from the symptoms what kind of flu you have. I know it can seem very confusing wit... Genetics and Health blogs http://www.medworm.com/rss/comments.php?id=2851969 Tue, 29 Sep 2009 05:54:05 +0100 2851969 http://www.medworm.com/index.php?rid=2842704&cid=t_278175_131_f&fid=34989&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FGeneticsHealth%2F%7E3%2FPiFMx9Tdeck%2F Countries all over the world are taking serious steps to stop the swine flu pandemic. China began its mass vaccination last week. And by October 5, the United States will distribute the first wave of swine flu vaccines, good for 6 million to million people. But the swiftness of government health agencies and the World Health Organization to address this issue is evidence about how rapid the H1N1 influenza virus has spread. It bears repeating that we need to take precautions in protecting ourselves and our families against the H1N1. What symptoms do you look for in swine flu? The symptoms of swine flu are similar to regular season flu, so report to your doctor if you have any symptoms. You will not know just from the symptoms what kind of flu you have. I know it can seem very confusing w... Genetics and Health blogs http://www.medworm.com/rss/comments.php?id=2842704 Tue, 29 Sep 2009 05:54:05 +0100 2842704 http://www.medworm.com/index.php?rid=2836084&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Fmedia.rawvoice.com%2Fpmn_twiv%2Fwww.twiv.tv%2FTWiV051.mp3 Hosts: Vincent Racaniello, Dick Despommier, and Alan Dove On episode #52 of the podcast “This Week in Virology”, Vincent, Dick, and Alan (with a cameo appearance by Rich Condit) review the world’s largest Phase III study of a complex HIV vaccine candidate in Thailand, immunization of salmon against infectious salmon anemia virus, and an outbreak of blueberry shock virus in Michigan. Download TWiV #51 (60 MB .mp3, 84 minutes) Subscribe to TWiV in iTunes, by the RSS feed, or by email Links for this episode: HIV vaccine shows promise for the first time – description of the program, FDA background document (pdf), NEJM review on why AIDS vaccine is difficult (pdf), and arguments for the trial Chile immunizes salmon (USGS article on the virus, pdf) Blueberry virus strikes Mi... virology blog blogs http://www.medworm.com/rss/comments.php?id=2836084 Sun, 27 Sep 2009 16:05:13 +0100 2836084 http://www.medworm.com/index.php?rid=2834388&cid=t_278175_131_f&fid=34989&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FGeneticsHealth%2F%7E3%2FBy_CVnLcEg0%2F The CDC has just announced that the first wave of swine flu vaccines will be available as early as October 5, a full month earlier than first reported. The supply will be good for 6 million to 7 million people, but the government expects about 250 million doses will be available over time. Of course, first priority goes to the most vulnerable, including healthcare workers, children, young adults and pregnant women. But don’t forget that you should still get a separate vaccine for the seasonal influenza. Neither one is going to protect you from the other virus. Now of the groups that the CDC highly recommends to get protection from the seasonal influenza virus, young adults were added on the list to get the swine flu shot. Don’t find this so strange. Even though this age group general... Genetics and Health blogs http://www.medworm.com/rss/comments.php?id=2834388 Fri, 25 Sep 2009 20:51:36 +0100 2834388 http://www.medworm.com/index.php?rid=2824344&cid=t_278175_131_f&fid=34989&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FGeneticsHealth%2F%7E3%2FrErGt51pNKM%2F With 1.3 billion people inside its borders, China seeks to curtail what could be a massive infection of the H1N1 virus later this winter by a mass immunization campaign this week. About 39,000 residents in Beijing had been inoculated with A/H1N1 flu vaccine by Tuesday afternoon, with 14 cases of adverse reaction, an epidemic control expert said here Wednesday. The number of inoculated residents may be small compared to the total population, but China is gaining praise for being the first country to issue such a campaign, and acting as fast as it did. The Sinovac H1N1 vaccine was approved only on September 3rd, and already 40,000 residents have been vaccinated by this Tuesday afternoon. China has also gained reputation as having the most vigilant response against the swine flu pandemic.... Genetics and Health blogs http://www.medworm.com/rss/comments.php?id=2824344 Wed, 23 Sep 2009 08:48:39 +0100 2824344 http://www.medworm.com/index.php?rid=2812262&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Fmedia.rawvoice.com%2Fpmn_twiv%2Fwww.twiv.tv%2FTWiV050.mp3 Hosts: Vincent Racaniello and Jason Rodriguez On episode #50 of the podcast “This Week in Virology”, Vincent and Jason review influenza 2009 H1N1 vaccine trials and protection against the virus conferred by the 1976 swine flu vaccine, then move on to a virus called XMRV and its possible role in prostate cancer. Download TWiV #50 (54 MB .mp3, 74 minutes) Subscribe to TWiV in iTunes, by the RSS feed, or by email Links for this episode: One dose of influenza 2009 H1N1 vaccine without adjuvant is enough Partially completed study on influenza 2009 H1N1 vaccine with MF59 adjuvant 1976 swine flu vaccine induces cross-reactive antibodies against influenza 2009 H1N1 strain Explanation of hemagglutination-inhibition and microneutralization assays FDA approves influenza 2009 H1N1 vaccine... virology blog blogs http://www.medworm.com/rss/comments.php?id=2812262 Sun, 20 Sep 2009 14:04:12 +0100 2812262 http://www.medworm.com/index.php?rid=2807795&cid=t_278175_131_f&fid=34989&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FGeneticsHealth%2F%7E3%2FXmpN4NVCu0U%2F Finally, we will have protection against the spreading H1N1 influenza! The Foods and Drug Administration just approved four vaccines against the swine flu virus and it looks like the vaccines will be available in a little over a month. Swine Flu H1N1 Vaccine Soon Available Clinical trials proved that the vaccines are safe and only one shot is needed to gain immunity against the virus, and that’s really great news. Most vaccines work best when, and after the booster shot is given so this means that the swine flu vaccine works more quickly than other flu vaccines. So remember, if you’re one of the following people that are in higher priority to be immunized, ask your doctor or pediatrician about its availability. I already told my doctors to call us as soon they have the vaccine so I can... Genetics and Health blogs http://www.medworm.com/rss/comments.php?id=2807795 Fri, 18 Sep 2009 13:16:01 +0100 2807795 http://www.medworm.com/index.php?rid=2800495&cid=t_278175_111_f&fid=36048&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FAHeartyLife%2F%7E3%2FAI8WuyYGRGk%2F FDA Approves Vaccines for 2009 H1N1 Influenza Virus Approval Provides Important Tool to Fight Pandemic The U.S. Food and Drug Administration announced today that it has approved four vaccines against the 2009 H1N1 influenza virus. The vaccines will be distributed nationally after the initial lots become available, which is expected within the next four weeks. “Today’s approval is good news for our nation’s response to the 2009 H1N1 influenza virus,” said Commissioner of Food and Drugs Margaret A. Hamburg, M.D. “This vaccine will help protect individuals from serious illness and death from influenza.” The vaccines are made by CSL Limited, MedImmune LLC, Novartis Vaccines and Diagnostics Limited, and sanofi pasteur Inc. All four firms manufacture the H1N1 vaccines usin... A Hearty Life blogs http://www.medworm.com/rss/comments.php?id=2800495 Wed, 16 Sep 2009 01:36:04 +0100 2800495 http://www.medworm.com/index.php?rid=3016948&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FVirologyBlog%2F%7E3%2F2seSIAybp2o%2F Would influenza virus be the same pathogen if it could not undergo reassortment of its segmented RNA genome? This is the question being asked in the wake of the development of a method to prevent the free assortment of influenza viral RNAs. The process of influenza virus replication includes the incorporation of eight viral RNAs into each newly synthesized virion. This process, called packaging, depends upon specific RNA sequences in each genome segment. By swapping the packaging sequences for the nonstructural protein (NS) and HA genes, a virus was produced which replicated but lost the ability to independently reassort the HA or NS gene. The authors note that the other influenza A virus RNA segments could be modified in a similar way to reduce or eliminate their ability to form reassorta... virology blog blogs http://www.medworm.com/rss/comments.php?id=3016948 Tue, 15 Sep 2009 12:00:10 +0100 3016948 http://www.medworm.com/index.php?rid=2789141&cid=t_278175_131_f&fid=34989&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FGeneticsHealth%2F%7E3%2FImknFN6vSe0%2F Now that our children are back to school, it’s a natural concern for parents to ask how we can protect our children against the swine flu epidemic and the seasonal winter flu! When is the swine flu vaccine available? Should we get two shots – one for each flu virus? Should I just keep my child home this year? Infectious disease experts from Seattle Children’s Hospital posted this YouTube video to answer the many questions we parents have about the H1N1 influenza virus and its vaccine. Related to this, a preliminary study found that a single standard dose is sufficient to produce an immune response and another study found that protection occurs in 8-10 days after vaccination. The video is great resource and worth watching. I think most of your questions would be answered by this PSA... Genetics and Health blogs http://www.medworm.com/rss/comments.php?id=2789141 Sat, 12 Sep 2009 03:59:34 +0100 2789141 http://www.medworm.com/index.php?rid=2786108&cid=t_278175_111_f&fid=36048&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FAHeartyLife%2F%7E3%2FQC-Xnh9Kd3o%2F We’ve been hearing about Tamiflu to help limit the effects of the H1N1 influenza and we’ve heard about the vaccines that are being made and tested right now. We’ve also heard about washing our hands, sneezing into our elbows and staying home while sick, but are their ways to help reduce the risk of getting the flu – any kind of flu – that we can take do on our own? Dr. Stuart Fischer, wellness expert and author of The Little Book of Big Medical Emergencies, says yes, there are. His tips focus on living a healthy and pro-active lifestyle, which would help reduce the risk of many illnesses, if you think about it. He offers five tips for you: LOSE THE EXTRA POUNDS: People who are overweight or obese (2/3 of the population) have other illnesses that compromise the... A Hearty Life blogs http://www.medworm.com/rss/comments.php?id=2786108 Fri, 11 Sep 2009 07:43:01 +0100 2786108 http://www.medworm.com/index.php?rid=3016950&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FVirologyBlog%2F%7E3%2FMeR-H0aFsuQ%2F An Australian group has reported results of a clinical trial to determine the safety and immunogenicity of a 2009 pandemic H1N1 influenza virus vaccine. Twenty-one days after the first of two scheduled doses, the vaccine proved to be immunogenic in adults. This is good news, as many had believed that two doses of the vaccine would be needed to achieve adequate protective immune responses. A total of 240 individuals were enrolled in the trial and given 15 or 30 microgram doses of an inactivated, H1N1 vaccine propagated in eggs by CSL Biotherapies, Parkville, Australia. Anti-influenza antibody titers were measured at enrollment and 21 days after each vaccination, by hemaggultination-inhibition (HI) and microneutralization assays. A single 15-µg or 30-µg dose of the H1N1 vaccine produced a ... virology blog blogs http://www.medworm.com/rss/comments.php?id=3016950 Fri, 11 Sep 2009 02:14:04 +0100 3016950 http://www.medworm.com/index.php?rid=3016951&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FVirologyBlog%2F%7E3%2FAEXeHXYmF5Y%2F When more than one influenza A virus subtype is circulating in humans, as has been the case since 1977, there are several possible outcomes. The viruses might co-circulate, one virus might out-compete another, or co-infection of cells with two viruses can lead to the production of genetically distinct viruses by the process of reassortment of viral RNAs. Experiments have been done in ferrets to determine how the 2009 pandemic H1N1 strain interacts with seasonal H3N2 and H1N1 viruses. Ferrets were intranasally co-infected with an H1N1 pandemic strain [Ca/04] and either a seasonal H1N1 virus [BR/59] or a seasonal H3N2 virus [BR/10].  One uninfected ferret was placed in the same cage (to allow contact transmission) and a second in another cage separated by a wire mesh (to allow aerosol trans... virology blog blogs http://www.medworm.com/rss/comments.php?id=3016951 Thu, 10 Sep 2009 12:00:05 +0100 3016951 http://www.medworm.com/index.php?rid=2768542&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FVirologyBlog%2F%7E3%2FJAeje41exuk%2F This week I had the pleasure of joining Chris Montera and his friends on “EMS Garage”, a weekly podcast for Emergency Medical Services professionals. We discussed basic information about the 2009 pandemic influenza H1N1 strain such as transmission and immunization plans, and what EMS personnel can do to help prevent the spread of infection. It was a pleasure podcasting with this crew – they are engaging and proud of their work. They are the ones who respond to emergencies, so head on over to EMS Garage to find EMS news, ambulance information, information for paramedics and EMTs, education, and just general fun. Listen to episode #51 to learn why Chris called it “Spit Shields UP H1N1″. (Source: virology blog) virology blog blogs http://www.medworm.com/rss/comments.php?id=2768542 Sat, 05 Sep 2009 13:00:23 +0100 2768542 http://www.medworm.com/index.php?rid=2765647&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FVirologyBlog%2F%7E3%2FLXJa_UWB1Fs%2F The Advisory Committee on Immunization Practices (ACIP) has released its recommendations on the use of influenza A (H1N1) 2009 monovalent vaccine. Here is my summary of the salient points. The report begins with information on who is contracting pandemic 2009 H1N1 influenza. The median age of persons with laboratory-confirmed infections in the United States is 12 years. The highest incidence of infection is among persons aged 5-24 years, and the lowest is in persons over 65 years of age. Similar findings have been reported in other countries. Comparison of the age distribution of hospitalized persons with laboratory-confirmed novel influenza A (H1N1) also shows a striking difference compared with seasonal influenza, as shown in the figure. As we have discussed previously, the reduced susc... virology blog blogs http://www.medworm.com/rss/comments.php?id=2765647 Fri, 04 Sep 2009 11:30:57 +0100 2765647 http://www.medworm.com/index.php?rid=2757384&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FVirologyBlog%2F%7E3%2FvXxeKrVVsmA%2F There has been a great deal of discussion about the use of adjuvants to improve the immunogenicity of vaccines against the 2009 H1N1 pandemic influenza strain. What effect do these compounds have on the immune response? Adjuvants are compounds added to vaccines that stimulate the immune response. They are often used when the antigen is in short supply, or does not induce a good antibody response. Because the 2009 H1N1 pandemic influenza strains do not replicate well in eggs, it has been suggested that adjuvants be used to ensure that there is sufficient supply of vaccine. A recent study demonstrates very clearly the effect of adjuvants on the immune response. Mice were immunized with egg-produced 2009 H1N1 influenza vaccine with or without the adjuvant MF59. A boost inoculation was given o... virology blog blogs http://www.medworm.com/rss/comments.php?id=2757384 Wed, 02 Sep 2009 03:16:11 +0100 2757384 http://www.medworm.com/index.php?rid=2747830&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Fmedia.rawvoice.com%2Fpmn_twiv%2Fwww.twiv.tv%2FTWiV047.mp3 Hosts: Vincent Racaniello and Dick Despommier On episode #47 of the podcast “This Week in Virology”, Vincent and Dick discuss influenza virus-like particle vaccines produced in insect and plant cells, rapid sharing of influenza research, and answer listener questions about cytomegalovirus, viral evolution and symbiosis and much more. Download TWiV #47 (51 MB .mp3, 71 minutes) Subscribe to TWiV in iTunes, by the RSS feed, or by email Links for this episode: A Farm on Every Floor Influenza virus-like particles in insect and plant cells PLoS Currents: Influenza Transmission of 2009 H1N1 influenza virus to turkeys [Thanks Debbie!] Baxter produces Vero cell H1N1 vaccine [Thanks Peter!] Boundaries of Darwinism podcast [Thanks David!] Phages in human intestine: papers one, t... virology blog blogs http://www.medworm.com/rss/comments.php?id=2747830 Sun, 30 Aug 2009 14:57:38 +0100 2747830 http://www.medworm.com/index.php?rid=2729844&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FVirologyBlog%2F%7E3%2F13puZm3Pk4E%2F In temperate climates, influenza displays distinct seasonality: infections mainly occur from November through March in the northern hemisphere, and from May to September in the southern hemisphere. The results of experiments in guinea pigs have revealed that aerosol transmission of influenza virus is most efficient in cold and dry conditions, and completely blocked at warm or humid conditions. Therefore it has been suggested that seasonality of influenza in temperate climates is regulated by temperature and humidity. In the tropics, influenza activity is more sporadic, occurring throughout the year or in temporally irregular outbreaks. One hypothesis to explain this pattern is that transmission in these areas occurs by contact, not by aerosol. To determine if influenza transmission by cont... virology blog blogs http://www.medworm.com/rss/comments.php?id=2729844 Tue, 25 Aug 2009 12:00:51 +0100 2729844 http://www.medworm.com/index.php?rid=2729845&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FVirologyBlog%2F%7E3%2FtXo-fQ7S6gQ%2F President Obama’s Council of Advisors on Science and Technology (PCAST) has released a report assessing H1N1 preparations. According to the White House Office of the Press Secretary: A Presidential advisory group of the nation’s leading scientists and engineers today released a new report assessing the Obama Administration’s preparations for this fall’s expected resurgence of 2009-H1N1 flu and outlining key steps officials can take in the coming weeks and months to minimize the disease’s impact on the nation. The Federal Government’s preparations for 2009-H1N1 flu have been well-organized and are scientifically grounded, according to the report by the President’s Council of Advisors on Science and Technology (PCAST), which assembled a subcommittee of experts on influenza ... virology blog blogs http://www.medworm.com/rss/comments.php?id=2729845 Mon, 24 Aug 2009 17:41:27 +0100 2729845 http://www.medworm.com/index.php?rid=2726966&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FVirologyBlog%2F%7E3%2FpfNIwmxZ_gk%2F The open-access Public Library of Science (PLoS) has launched PLoS Currents, a website for the rapid communication of research results and ideas. The first research theme at PLoS Currents is influenza. The opening of PLoS Currents: Influenza was announced by Harold Varmus, Chairman and Co-Founder of PLoS. He wrote about the reasons for starting this website at The Official Google Blog: The key goal of PLoS Currents is to accelerate scientific discovery by allowing researchers to share their latest findings and ideas immediately with the world’s scientific and medical communities. Google Knol’s features for community interaction, comment and discussion will enable commentary and conversations to develop around these findings. Given that the contributions to PLoS Currents are not peer-re... virology blog blogs http://www.medworm.com/rss/comments.php?id=2726966 Fri, 21 Aug 2009 13:07:43 +0100 2726966 http://www.medworm.com/index.php?rid=2726967&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FVirologyBlog%2F%7E3%2Fp7SovphIZeY%2F A new type of vaccine against influenza, made with virus-like particles, has been shown to protect ferrets from infection with the 2009 H1N1 swine-origin strain. What is a virus-like particle, and how is it produced? If you have been taking influenza 101, you know that new virus particles are produced in infected cells by budding. During this process, the membrane bulges from the cell and is eventually pinched off to form a free particle. These virus particles contain the viral RNA segments, and an assortment of viral proteins including PA, PB1, PB2, NP, M1, M2, HA, and NA. But not all of those viral proteins are needed to produce an influenza virus particle. When only the viral HA, NA, and M1 proteins are synthesized in cells, particles are released from cells that look very much like in... virology blog blogs http://www.medworm.com/rss/comments.php?id=2726967 Wed, 19 Aug 2009 14:03:47 +0100 2726967 http://www.medworm.com/index.php?rid=2709080&cid=t_278175_86_f&fid=36669&url=http%3A%2F%2Ffadelibrary.wordpress.com%2F2009%2F08%2F18%2Fthe-lancet-2009-volume-374-issue-9688%2F Contents Page Fade Fave:H1N1 2009 influenza virus infection during pregnancy in the USA Fade Skinny:Identifies that pregnant women might be at increased risk for complications from pandemic H1N1 virus infection. These data lend support to the present recommendation to promptly treat pregnant women with H1N1 influenza virus infection with anti-influenza drugs. (Print Subscription Held by the Fade Library) Posted in Current Awareness Tagged: Antivirals, Current Awareness, H1N1, Influenza, Journals, Pregnancy (Source: Fade Library) Fade Library blogs http://www.medworm.com/rss/comments.php?id=2709080 Tue, 18 Aug 2009 10:02:19 +0100 2709080 http://www.medworm.com/index.php?rid=2709129&cid=t_278175_87_f&fid=34935&url=http%3A%2F%2Fmedicine.com.my%2Fwp%2F%3Fp%3D7693 Dr. Vadivale, the Malaysian Cyberdoc, has put up a comprehensive Influenza A H1N1 page in his Vadscorner website. Go check it out! from the Malaysian Medical Resources Cyberdoc’s H1N1 page (Source: Malaysian Medical Resources) Malaysian Medical Resources blogs http://www.medworm.com/rss/comments.php?id=2709129 Sun, 16 Aug 2009 23:00:00 +0100 2709129 http://www.medworm.com/index.php?rid=2726970&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FVirologyBlog%2F%7E3%2FckUdeyQLhL0%2F When the 2009 H1N1 pandemic influenza virus emerged earlier this year, I began re-reading John Barry’s The Great Influenza. I came across the sentences that I had underlined during my first read identifying errors in basic virology. Because this is a very popular book, it’s important to identify the mistakes and correct them. Barry is not a virologist, or any type of scientist. He’s a historian who happens to have written on influenza. This does not excuse the virological errors in his book; he  should have had a virologist fact-check the manuscript before publication. Page citations refer to the Penguin Books paperbound version. When a virus successfully invades a cell, it inserts its own genes into the cell’s genome, and the viral genes seize control from the cel... virology blog blogs http://www.medworm.com/rss/comments.php?id=2726970 Fri, 14 Aug 2009 13:00:00 +0100 2726970 http://www.medworm.com/index.php?rid=2726971&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FVirologyBlog%2F%7E3%2FvnWSeCkpj0I%2F We’ve had several discussions on the value of personal protective equipment (PPE) in preventing influenza infection. CIDRAP has an excellent summary of an Institute of Medicine meeting on this subject. The IOM has been asked to make recommendations about how to protect healthcare workers against swine-origin H1N1 influenza. An unpublished study of respiratory protection in hospital workers in Beijing compared the effectiveness of surgical masks, fit- and non-fit tested N95 respirators in conferring protection from clinical respiratory illness, influenza-like illness, and laboratory confirmed influenza. Surgical masks were not effective, while those wearing N95 masks had 75% protection against influenza. Whether the N95 was fit-tested or not made no difference. Also discussed were ... virology blog blogs http://www.medworm.com/rss/comments.php?id=2726971 Thu, 13 Aug 2009 15:10:23 +0100 2726971 http://www.medworm.com/index.php?rid=2678695&cid=t_278175_111_f&fid=36048&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FAHeartyLife%2F%7E3%2Fewy1bBxNvqk%2F Experts from the World Health Organization (WHO) have said that the world seems to be on track for the first H1N1 influenza vaccines to be approved by September. The so-called swine flu has been making its way around the world and scientists have been working at developing a vaccine before the virus makes its second wave, affecting even more people. Developing a vaccine is intense work that can go in the wrong direction at any time. The many steps involved in developing the vaccine and ensuring  its safety and efficacy takes time. The WHO has outlined how this is done in their posting  Pandemic influenza vaccine manufacturing process and timeline . It’s interesting to read how the development occurs. At this point, the process is in the clinical trial phase for some of the manufact... A Hearty Life blogs http://www.medworm.com/rss/comments.php?id=2678695 Thu, 06 Aug 2009 14:01:43 +0100 2678695 http://www.medworm.com/index.php?rid=2678618&cid=t_278175_87_f&fid=34935&url=http%3A%2F%2Fmedicine.com.my%2Fwp%2F%3Fp%3D7613 by Dr David KL Quek President MMA. 1) Can we distinguish between regular and H1N1 flu, without a lab test? No, the flu is the flu, but there are variations in presentation. Some symptoms such as cough, runny nose, fever, body aches, fatigue, vomiting, diarrhoea occur more or less in every flu patient, but may present differently by different people. Some infected people have very mild symptoms, some in between, and a small minority, probably less than 10%, have severe features including the dangerous pneumonia. However, from sentinel testing and surveillance by the Ministry of Health the last few weeks have shown that almost 95% of all flu-like illness are now caused by the H1N1 virus. Earlier some months ago, seasonal flu variants caused by the B and other A virus were the main causes, t... Malaysian Medical Resources blogs http://www.medworm.com/rss/comments.php?id=2678618 Wed, 05 Aug 2009 23:00:00 +0100 2678618 http://www.medworm.com/index.php?rid=2741083&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Fmedia.rawvoice.com%2Fpmn_twiv%2Fwww.twiv.tv%2FTWiV043.mp3 Hosts: Vincent Racaniello and Dick Despommier In episode 43 of the podcast “This Week in Virology”, Vincent and Dick explain virus classification, and revisit the 1976 swine flu immunization campaign and Guillain-Barré syndrome. Download TWiV #43 (32 MB .mp3, 46 minutes) Subscribe to TWiV in iTunes, by the RSS feed, or by email Links for this episode: International Committee on the Taxonomy of Viruses (ICTV) CBS 60 Minutes on 1976 swine flu vaccine (thanks Gus and Swiss compass!) Vaccines and Guillain-Barré NINDS Guillain-Barré Information Reflections on the 1976 swine flu vaccination program Swine influenza outbreak at Fort Dix, 1976 Weekly Science Picks Dick Five Kingdoms: An Illustrated Guide to the Phyla of Life on Earth by Lynn Margulis and Karlene V. Schwartz Vin... virology blog blogs http://www.medworm.com/rss/comments.php?id=2741083 Mon, 03 Aug 2009 02:52:49 +0100 2741083 http://www.medworm.com/index.php?rid=2741084&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FVirologyBlog%2F%7E3%2FBRdGyNPRH4s%2F A few weeks ago I asked readers to find the errors in the following statement concerning an experimental influenza vaccine produced by Protein Sciences which involves synthesis of the viral HA protein in insect cells. They warned that the virus could mutate during the southern hemisphere’s flu season before returning north in a more lethal form in autumn, in a pattern similar to that seen in the deadly 1918 flu pandemic, which claimed an estimated 20 to 50 million lives around the globe. The CDC (Centers for Disease Control and Prevention) sent us a dead virus, which is perfectly safe, and then we extracted genetic information from that virus. The statement ‘in a pattern similar to that seen in the deadly 1918 flu pandemic’ is wrong. There is no evidence that mutation le... virology blog blogs http://www.medworm.com/rss/comments.php?id=2741084 Thu, 30 Jul 2009 13:00:08 +0100 2741084 http://www.medworm.com/index.php?rid=2653692&cid=t_278175_87_f&fid=34935&url=http%3A%2F%2Fmedicine.com.my%2Fwp%2F%3Fp%3D7516 PDF in an online presentation format (using PdfMeNot.com) of slides by Dr. Christopher Lee (original source from MOH) (view Online presentation in new window) from the Malaysian Medical Resources Influenza A #H1N1 Managing the 2009 Pan Flu patient (Source: Malaysian Medical Resources) Malaysian Medical Resources blogs http://www.medworm.com/rss/comments.php?id=2653692 Tue, 28 Jul 2009 23:00:00 +0100 2653692 http://www.medworm.com/index.php?rid=2621774&cid=t_278175_87_f&fid=34935&url=http%3A%2F%2Fmedicine.com.my%2Fwp%2F%3Fp%3D7485 A 49 year old man recently became Singapore’s first H1N1 related death. The Malaysian Insider reports A 49-year-old man with heart problems yesterday became the first person here to die after being infected by the Influenza A (H1N1) virus. In a statement released last night, the Health Ministry said the man, who had multiple health problems, died of a heart attack contributed by severe pneumonia and the H1N1 infection. Prior to the flu virus infection, he was already suffering from diabetes, hypertension and high cholesterol. It’s only a matter of time before Malaysia records it’s first H1N1 death. Although at the moment the mortality rate is low (holding at 0.43% according to this source) and only slightly higher than the mortality rate of seasonal flu which is about 0.... Malaysian Medical Resources blogs http://www.medworm.com/rss/comments.php?id=2621774 Sun, 19 Jul 2009 23:00:00 +0100 2621774 http://www.medworm.com/index.php?rid=2606008&cid=t_278175_107_f&fid=36672&url=http%3A%2F%2Fwww.sciencebase.com%2Fscience-blog%2Fswine-flu-trending-again.html The UK media has been full of swine flu (H1N1) again this week, it’s been trending, to borrow Twitter terminology, what with reports on the tragic deaths of a young girl and a family doctor, advice on virulence and research from Imperial College London that suggests we need better research into the disease. Widespread anecdotal evidence of the spread of H1N1 abounds too. I should also point out that since coming back from WCSJ09 I’ve had a rather nasty cough, a bit of a sore throat and have felt quite lethargic…but that’s more likely to do with all the mixing in smoky Westminster pub outdoor areas and the talking loudly to be heard over speakers at social events (apologies Natasha, Ed). Anyway, back to the swine flu. The number of people contacting their doctor beca... Sciencebase Science Blog blogs http://www.medworm.com/rss/comments.php?id=2606008 Thu, 16 Jul 2009 12:00:16 +0100 2606008 http://www.medworm.com/index.php?rid=2741092&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FVirologyBlog%2F%7E3%2FT32I9DVDD34%2F This study shows that is not the case. There is clear evidence the virus is different than seasonal influenza. I’m puzzled by this statement. As far as I know, the 2009 H1N1 strain has so far likely infected millions of people, and most have concluded that the disease is no more severe than seasonal influenza. Are mice, ferrets, and non-human primates more reliable indicators of influenza virus virulence than humans? I agree that the 2009 H1N1 influenza virus does seem to multiply more extensively in the respiratory tract than a seasonal H1N1 strain, as does the 1918 virus. But how many influenza virus strains have been studied in such animals? There are probably others that can replicate in the lower tract of experimental animals but are not very pathogenic in humans. Two other rese... virology blog blogs http://www.medworm.com/rss/comments.php?id=2741092 Wed, 15 Jul 2009 20:09:49 +0100 2741092 http://www.medworm.com/index.php?rid=2741094&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Fmedia.rawvoice.com%2Fpmn_twiv%2Fwww.twiv.tv%2FTWiV040.mp3 Hosts: Vincent Racaniello, Dick Despommier, and Alan Dove On episode #40 of the podcast “This Week in Virology”, Vincent, Dick, and Alan consider Reston ebolavirus in swine, historical perspective of H1N1 influenza virus emergence and circulation, Tamiflu-resistant H1N1, Tamiflu in Japanese river waters, transmission of H1N1 virus in ferrets, and pneumonia and respiratory failure from H1N1 in Mexico. Download TWiV #40 (49 MB .mp3, 70 minutes) Subscribe to TWiV in iTunes, by the RSS feed, or by email Links for this episode: Reston ebolavirus in Philippine swine Historical perspective on H1N1 virus Salk’s 1947 article on flu vaccine failure Persistent legacy of 1918 H1N1 virus Tamiflu resistant H1N1 virus (AP article) Tamiflu in Japanese river waters H1N1 infecti... virology blog blogs http://www.medworm.com/rss/comments.php?id=2741094 Sun, 12 Jul 2009 13:33:58 +0100 2741094 http://www.medworm.com/index.php?rid=2594424&cid=t_278175_87_f&fid=34935&url=http%3A%2F%2Fmedicine.com.my%2Fwp%2F%3Fp%3D7434 The Health Minister recently announced that Malaysia has decided to stop trying to contain #H1N1 (it really was a futile exercise IMO) and finally gone on to a mitigation phase. Containment has already clearly failed in other countries as this strain is so infectious it is not surprising. The only hope of “containment” is really when there is enough “herd immunity” and apart from natural infections will come in the way of a vaccine when it is available in sufficient quantities. The MMA President, Dr. David Quek recently shared his views on this topic in an NST Crosstalk. If you missed it, don’t worry since David is a medical blogger, you can read his post here: H1N1 Flu: Onwards to Mitigation Phase…. David emphasizes: As we progress from containment to m... Malaysian Medical Resources blogs http://www.medworm.com/rss/comments.php?id=2594424 Sat, 11 Jul 2009 23:00:00 +0100 2594424 http://www.medworm.com/index.php?rid=2741095&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FVirologyBlog%2F%7E3%2FUZoKyscgtG8%2F Tamiflu (Oseltamivir) is one of the few antiviral drugs available for treatment of influenza. Use of the drug has increased substantially because of the emergence of the 2009 H1N1 pandemic strain, against which no vaccine is yet available. A recent study has shown that low levels of oseltamivir can be detected in the aquatic environment. This finding raises the possibility that aquatic birds which harbor influenza virus could be exposed to the antiviral, leading to selection of drug resistant viruses. Oseltamivir is an inhibitor of the influenza neuraminidase (NA) glycoprotein. This enzyme removes sialic acids from the surface of the cell, so that newly formed virions can be released. Neuraminidase inhibitors such as Tamiflu and Relenza function by preventing cleavage of sialic acid from ... virology blog blogs http://www.medworm.com/rss/comments.php?id=2741095 Fri, 10 Jul 2009 16:38:35 +0100 2741095 http://www.medworm.com/index.php?rid=2741098&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Fmedia.rawvoice.com%2Fpmn_twiv%2Fwww.twiv.tv%2FTWiV039.mp3 Hosts: Vincent Racaniello and Dick Despommier On episode #39 of the podcast “This Week in Virology”, Vincent and Dick discuss virus structure and answer listener questions. Download TWiV #39 (37 MB .mp3, 53 minutes) Subscribe to TWiV in iTunes, by the RSS feed, or by email Links for this episode: Boston Globe article on Genzyme FDA warning letter to Genzyme (thanks Peter!) Public Health Reports July – December 1918 (thanks Lenn!) Amateur scientists working with professionals (thanks Ennio!) Influenza H1N1 and computer analogies (thanks swiss compass!) Bone marrow transplant to cure AIDS not reported (thanks Andrew!) Paul Offitt interview on vaccines and autism Mark Crislip on vaccines and autism Weekly Science Picks Dick Visual Explanations by Edward R. Tufte... virology blog blogs http://www.medworm.com/rss/comments.php?id=2741098 Mon, 06 Jul 2009 03:45:54 +0100 2741098 http://www.medworm.com/index.php?rid=2741102&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FVirologyBlog%2F%7E3%2FfC048IJzgv8%2F Mutation is an important source of RNA virus diversity that is made possible by the error-prone nature of RNA synthesis. Viruses with segmented genomes, such as influenza virus, have another mechanism for generating diversity: reassortment. When an influenza virus infects a cell, the individual RNA segments enter the nucleus. There they are copied many times to form RNA genomes for new infectious virions. The new RNA segments are exported to the cytoplasm, and then are incorporated into new virus particles which bud from the cell. If a cell is infected with two different influenza viruses, the RNAs of both viruses are copied in the nucleus. When new virus particles are assembled at the plasma membrane, each of the 8 RNA segments may originate from either infecting virus. The progeny that i... virology blog blogs http://www.medworm.com/rss/comments.php?id=2741102 Mon, 29 Jun 2009 14:00:11 +0100 2741102 http://www.medworm.com/index.php?rid=2741103&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Fmedia.rawvoice.com%2Fpmn_twiv%2Fwww.twiv.tv%2FTWiV038.mp3 Hosts: Vincent Racaniello and Glenn Rall On episode #38 of the podcast “This Week in Virology”, Vincent and Glenn Rall chat about koi herpesvirus, H1N1 influenza vaccine produced in insect cells, attack by a rabid raccoon, and measles. Download TWiV #38 (63 MB .mp3, 91 minutes) Subscribe to TWiV in iTunes, by the RSS feed, or by email Links for this episode: Virus suspected in carp die-off: koi herpesvirus H1N1 influenza vaccine produced in insect cells with baculovirus vectors Outbreak of measles in Wales Production of influenza vaccines in cell cultures: MDCK, Vero, PER.C6, EB66, insect (thanks Peter!) Weekly Science Picks Glenn Riddled with Life by Marlene Zuk Vincent All the Virology on the WWW Send your virology questions and comments (email or mp3 file) to... virology blog blogs http://www.medworm.com/rss/comments.php?id=2741103 Sun, 28 Jun 2009 11:05:31 +0100 2741103 http://www.medworm.com/index.php?rid=2741104&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FVirologyBlog%2F%7E3%2Fng8rKG41cKE%2F The RNA genome of influenza viruses is segmented . The virions of influenza A and B viruses contain 8 different RNAs, while those of influenza C viruses contain 7. How is the correct number of RNA segments inserted into newly synthesized virus particles? During influenza virus assembly, viral RNAs and viral proteins – called a ribonucleoprotein complex or RNP -  travels to the plasma membrane. There the virion forms by a process called budding, during which the membrane bulges from the cell and is eventually pinched off to form a free particle. Production of an infectious virus particle requires incorporation of at least one copy of each of the eight RNA segments. Two different mechanisms – random and selective packaging – have been proposed to explain how each virion recei... virology blog blogs http://www.medworm.com/rss/comments.php?id=2741104 Fri, 26 Jun 2009 14:00:27 +0100 2741104 http://www.medworm.com/index.php?rid=2741107&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FVirologyBlog%2F%7E3%2F36EMPCU5Q-0%2F Soon after the new influenza H1N1 strain emerged in April 2009, I began a series of blog posts on basic aspects of influenza virus replication and pathogenesis. The goal of this series is to provide information that will allow everyone to better understand the events surrounding emergence and spread of the new pandemic strain. Unfortunately blog posts tend to become invisible after a certain period of time, which does not befit educational material. Therefore I have made a list of these articles, with links, to make it easier for everyone to take Influenza 101. As new basic information on influenza is added to the blog, it will appear on the Influenza 101 page. You can find Influenza 101 by clicking the tab above the banner image of this blog, or by going to this page. Class is still in se... virology blog blogs http://www.medworm.com/rss/comments.php?id=2741107 Wed, 24 Jun 2009 11:25:47 +0100 2741107 http://www.medworm.com/index.php?rid=2741111&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Fmedia.rawvoice.com%2Fpmn_twiv%2Fwww.twiv.tv%2FTWiV037.mp3 Hosts: Vincent Racaniello, Alan Dove, and Eric O. Freed On episode 37 of the podcast “This Week in Virology ” (TWiV), Vincent, Alan, and Eric Freed talk about vesivirus contamination of bioreactors, pandemic influenza, maximizing the effect of vaccination by targeting children, chikungunya virus, and open access scientific journals. Download TWiV #37 (51 MB .mp3, 74 minutes) Subscribe to TWiV in iTunes, by the RSS feed, or by email Links for this episode: Genzyme shuts down manufacturing of two enzyme drugs because of vesivirus contamination Brazilian H1N1 isolate is not novel WHO interactive H1N1 map Targeting children maximizes the effect of vaccination Chikungunya virus and Aedes mosquitoes Viruses, an open-access virology journal iBioSeminars A field study of virus removal... virology blog blogs http://www.medworm.com/rss/comments.php?id=2741111 Sun, 21 Jun 2009 13:41:04 +0100 2741111 http://www.medworm.com/index.php?rid=2741115&cid=t_278175_139_f&fid=38879&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FVirologyBlog%2F%7E3%2FI40CaL3fkHI%2F WHO reports that as of 15 June 2009, 76 countries have officially reported 35, 928 cases of influenza A(H1N1) infection, including 163 deaths. These numbers can be used to calculate a case fatality ratio (CFR) of 0.45%. Is this number an accurate indication of the lethality of influenza? Determining how many people die from influenza is a tricky business. The main problem is that not every influenza virus infection is confirmed by laboratory testing. For example, early in the Mexico H1N1 outbreak, the apparent CFR was much higher because the total number of infections had not been established. Even with the intense surveillance being conducted at the onset of this pandemic, many infections are still not diagnosed. Virologic surveillance is likely become even more incomplete as health syste... virology blog blogs http://www.medworm.com/rss/comments.php?id=2741115 Tue, 16 Jun 2009 21:30:24 +0100 2741115 http://www.medworm.com/index.php?rid=2469552&cid=t_278175_107_f&fid=36672&url=http%3A%2F%2Fwww.sciencebase.com%2Fscience-blog%2Fh1n1-swine-flu-update.html Many virologists, including Vincent Racaniello, have suggested that the threat of avian influenza (H5N1) was greatly overestimated and so distracted us from more serious threats. Back in early 2005, he suggested that another strain might underpin a pandemic, such as H2N2, it may yet do just that. In the meantime, he was essentially right in that H1N1, previously known as “swine flu” emerged in March this year in Mexico (not Asia). He suggests that we really shouldn’t underestimate viruses. US Centers for Disease Control and Prevention (CDC), in its weekly report on flu, suggested that the decline in infections during the last week of May in the US is important but the numbers still represent higher levels of influenza-like illness than is normal for this time of year. Ric... Sciencebase Science Blog blogs http://www.medworm.com/rss/comments.php?id=2469552 Wed, 10 Jun 2009 21:22:32 +0100 2469552 http://www.medworm.com/index.php?rid=2452431&cid=t_278175_87_f&fid=34935&url=http%3A%2F%2Fmedicine.com.my%2Fwp%2F%3Fp%3D7133 The world is “getting closer” to a full-scale H1N1 flu pandemic, the World Health Organization (WHO) warns. WebMD has the story: When “swine flu” burst upon the world in April, the WHO rapidly raised its warning level from phase 4 and then to phase 5 as it became clear a flu virus new to humans was spreading easily — and widely — from person to person. “Globally we believe we are at phase 5 but getting closer to phase 6,” Fukuda said today at a news conference. “It is clear the virus continues to spread internationally. There are a number of countries that appear to be in transition [to widespread infections at the community level]. These countries include the U.K., Spain, Japan, Chile, and also Australia.” When the WHO finally d... Malaysian Medical Resources blogs http://www.medworm.com/rss/comments.php?id=2452431 Wed, 03 Jun 2009 04:00:00 +0100 2452431 http://www.medworm.com/index.php?rid=2389850&cid=t_278175_107_f&fid=36672&url=http%3A%2F%2Fwww.sciencebase.com%2Fscience-blog%2Fswine-flu-update.html Swine flu (H1N1) information leaflets are being delivered to households across the UK today. I suspect they do nothing but increase fear and confuse people, especially as the WHO/UN are about to lower the swine flu alert level. In the UK, 27 people now have the virus, with 23 in England and four in Scotland and the first P2P transmission in the UK has been reported. But, what happened to the thousands, if not millions, affected we were warned of by the media and government and WHO and UN over the last few weeks? It just hasn’t happened, thankfully. The leaflets will, of course, explain exactly what is swine flu (I wonder whether they will explain why we now have to call it H1N1 though), who is most at risk, what are the symptoms, and what people can do to reduce their risk of catchin... Sciencebase Science Blog blogs http://www.medworm.com/rss/comments.php?id=2389850 Thu, 07 May 2009 07:04:39 +0100 2389850 http://www.medworm.com/index.php?rid=2387187&cid=t_278175_136_f&fid=36070&url=http%3A%2F%2Fnetwork.nature.com%2Fpeople%2Fbasanta%2Fblog%2F2009%2F05%2F02%2Fanother-one-on-the-h1n1-influenza-virus The (medical) news in the last few days has been, without doubt, the H1N1 strain commonly found in pigs (aka Swine/Mexican) flu. The journalistic news of the week was probably the treatment of the outbreak with different outlets either downplaying the importance of the virus [Guardian] or preparing their readership for imminent doom [El Pais, ES] For those that are skeptic about the role of science in society (beyond that of fostering knowledge for cross words and collecting random facts) look no further than the specials put together by the likes of Science or Nature. The knowledge we now have will be crucial in understanding and containing this (and future) pandemics. It is not the fruit of a few days of work but has been distelled through many years of work when the political and social... Cancerevo: Evolution and cancer blogs http://www.medworm.com/rss/comments.php?id=2387187 Sun, 03 May 2009 23:14:25 +0100 2387187