MedWorm provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest medical blog items that have been tagged with 'hepatitis c'. Sat, 03 Sep 2011 02:10:26 +0100 http://www.medworm.com/index.php?rid=5119916&cid=t_119684_10_f&fid=35345&url=http%3A%2F%2Fwww.GIDEONonline.com%2F2011%2F08%2F11%2Fhepatitis-c-in-scotland%2F A recent post in ProMED highlights the fact that rates of Hepatitis C in Scotland are more than seven-fold higher than those of neighboring countries, and twenty-fold those reported in the United States. [1,2] See graph References: 1. Berger SA. Infectious Diseases of Scotland, 2011. 403 pp, 140 graphs, 1233 references. Gideon e-books, http://www.gideononline.com/ebooks/country/infectious-diseases-of-scotland/ 2. Berger SA. Hepatitis C: Global Status, 2011. 164 pp, 160 graphs, 1500 references. Gideonn e-books, http://www.gideononline.com/ebooks/disease/hepatitis-c-global-status/ (Source: GIDEON blog) GIDEON blog blogs http://www.medworm.com/rss/comments.php?id=5119916 Thu, 11 Aug 2011 17:56:40 +0100 5119916 http://www.medworm.com/index.php?rid=5069822&cid=t_119684_150_f&fid=35777&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FPharmalot%2F%7E3%2F8WFD_ZbuCB4%2F Hello, everyone, and top of the morning to you. Another shiny day is unfolding on the Pharmalot corporate campus, where we have much to do. You know, the drill - reading documents, making phone calls, finding interesting tidbits. To prepare, yes, we are downing that mandatory cup of stimulation - our flavor today is Wild Mountain Blueberry. So please join us. Meanwhile, here are some items from around the world. Hope your day goes well and stay in touch… Pfizer’s Zyvox and Antidepressants May Cause Fatal Reaction (Bloomberg News) Valeant Approaches Swedish Drugmaker Mada About A Takeover (Bloomberg News) Abortion Pill Given Via Telemedicine Is Safe And Effective (Reuters) Vertex Says Hepatitis C Drug Combo Works (Reuters) Naeja Pharmaceutical R&D Facility Catches Fire (Cal... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=5069822 Wed, 27 Jul 2011 11:41:22 +0100 5069822 http://www.medworm.com/index.php?rid=5018725&cid=t_119684_139_f&fid=38879&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FVirologyBlog%2F%7E3%2F2aql2DLq09Q%2F Hosts: Vincent Racaniello, Rich Condit, Dickson Despommier, Alan Dove, and Matt Evans Matt Evans joins Vincent, Rich, Dickson, and Alan to deconstruct a mouse model for hepatitis C virus infection. Click the arrow above to play, or right-click to download TWiV #141 (117 MB .mp3, 97 minutes). Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app. Links for this episode: Mouse model for HCV infection (Nature) Commentary on HCV mouse model (Nature) Matt Evans on the Wall Street Journal Report TWiV on Facebook Letters read on TWiV 141 Weekly Science Picks Matt – Benezra letter to NIH (pdf); (NIH response and Nature commentary) Dickson – The Big Thirst by Charles Fishman Alan – Ea... virology blog blogs http://www.medworm.com/rss/comments.php?id=5018725 Sun, 10 Jul 2011 15:39:17 +0100 5018725 http://www.medworm.com/index.php?rid=4976206&cid=t_119684_150_f&fid=35777&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FPharmalot%2F%7E3%2FvinqO6QozGE%2F Hello, again. And how are you this morning? A beautiful day is unfolding here on the Pharmalot corporate campus - the birds are chirping, the official mascots are lounging about and the cup of stimulation is brewing. Meanwhile, we are looking forward to another day of R&D. We know you can relate. To help you along, here are some tidbits. Hope your day goes well and stay in touch… Vertex Tops Merck In Hep C Drug Launch (The Street) Glaxo R&D Chief Says Advair Is Safe From Generics (Reuters) J&J Plans To Market More Products Under The Janssen Name (Financial Times) New Prostate Cancer Drugs Are Expensive (New York Times) Amgen Sells $3 Billion In Bonds To Pay For Dividends (Bloomberg News) Diabetes Cases In Adults Worldwide Has Doubled In 30 Years (Reuters) India Suspend... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=4976206 Tue, 28 Jun 2011 11:45:08 +0100 4976206 http://www.medworm.com/index.php?rid=4933163&cid=t_119684_139_f&fid=38879&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FVirologyBlog%2F%7E3%2FUcJTKTXAtMw%2F Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Dickson Despommier, Amit Kapoor, and Ian Lipkin The TWiV team speaks with Amit Kapoor and Ian Lipkin about how they discovered canine hepacivirus, and its implications for the origin and evolution of hepatitis C virus. Click the arrow above to play, or right-click to download TWiV #137 (69 MB .mp3, 96 minutes). Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app. Links for this episode: Characterization of canine hepacivirus (PNAS) Humanized mouse model for HCV (EurekAlert!) Summary of CHV study from Mailman School of Public Health Center for Infection and Immunity at Columbia University TWiV on Facebook Letters read on TWiV 137 Weekly Sc... virology blog blogs http://www.medworm.com/rss/comments.php?id=4933163 Sun, 12 Jun 2011 22:38:40 +0100 4933163 http://www.medworm.com/index.php?rid=4871355&cid=t_119684_139_f&fid=38879&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FVirologyBlog%2F%7E3%2F2LnQ9MMrxr0%2F Contemporary human viruses most likely originated by cross-species transmission from non-human animals. Examples include HIV-1, which crossed from chimpanzees to humans, and SARS coronavirus, which originated in bats. Since the 1989 discovery of hepatitis C virus (classified as a hepacivirus in the family Flaviviridae) the origin of the virus been obscure. During the characterization of respiratory infections of domestic dogs, a virus was discovered that is the most genetically similar animal virus homolog of HCV. HCV is a substantial human pathogen: 200 million people worldwide are chronically infected and are at risk for the development of hepatocellular carcinoma. The source of HCV is unknown because there are no closely related animal virus homologs, but the hunt for related viruses ha... virology blog blogs http://www.medworm.com/rss/comments.php?id=4871355 Thu, 26 May 2011 02:02:42 +0100 4871355 http://www.medworm.com/index.php?rid=4862925&cid=t_119684_150_f&fid=35777&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FPharmalot%2F%7E3%2FYGVnVGNyT4k%2F Hello, everyone, and top of the morning to you. A lovely day is emerging here on the Pharmalot corporate campus, although this will be a busy one as we prepare for those meetings and deadlines. We know you relate, so please join us for a cup of stimulation - our flavor today is Rain Forest Nut. Or grab a bottle of water if you prefer. Meanwhile, here are some tidbits from around the world, such as it is. Hope your day is swell and you achieve your goals. See you later… SEC Expected To Act On Whistleblower Program (Washington Post) Deaths In Pfizer Arthritis Drug Trial Are Under A Microscope (Reuters) Vertex And Its Small, But Experienced Sales Force (Dow Jones) Watson Pays $562M For Generic Drug Developer (Reuters) Bayer and J&J’s Xarelto Prevented Repeat Strokes In Analys... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=4862925 Wed, 25 May 2011 12:02:24 +0100 4862925 http://www.medworm.com/index.php?rid=4829305&cid=t_119684_150_f&fid=35777&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FPharmalot%2F%7E3%2F9d0neOmCpbU%2F Late last week, the FDA approved a much-anticipated hepatitis C treatment from Merck, which the drugmaker inherited as part of its acquisition of Schering-Plough (see here). The move, which is the first FDA endorsement of a new hepatitis C med in a decade, came just 10 days before Vertex Pharmaceuticals is expected to win approval of its own drug, setting off a new round of speculation about what is certain to be an expensive and highly interesting battle. The US market alone offers substantial potential with an estimated 3.2 million Americans suffering from the afflication, including an untold number who may not be aware they are infected. Both Merck and Vertex, of course, will work hard to raise awareness. And their meds would be used in combination with older treatments - peginterferon ... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=4829305 Mon, 16 May 2011 13:09:51 +0100 4829305 http://www.medworm.com/index.php?rid=4780487&cid=t_119684_150_f&fid=35777&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FPharmalot%2F%7E3%2FE701Bp9oFBU%2F The FDA Bad Ad program, in which someone drops a dime on offending promotional materials, has turned up another violator. The latest is Three Rivers Pharmaceuticals, which is headed by former ImClone Systems ceo and convicted inside trader, Sam Waksal. In a warning letter posted on the FDA web site, Sam & Co. are taken to task for a host of offenses in connection with a Statgram communication for the Infergen hepatitis c treatment - omitting and minimizing risk info; broadening the indication and omitting important facts; overstating efficiacy; making unsubstantiated claims, and failing to provide adequate directions for use. In short, Three Rivers did almost nothing right. Topping the list: the Statgram claims docs can obtain additional prescribing info, including the safety profile ... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=4780487 Tue, 03 May 2011 12:34:48 +0100 4780487 http://www.medworm.com/index.php?rid=4768250&cid=t_119684_150_f&fid=35777&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FPharmalot%2F%7E3%2FEKnIm6NQuKw%2F Another working week is about to draw to a close. And not a moment too soon. This is, of course, the signal to daydream about weekend plans. Our modest agenda includes a family gathering, mowing the lawn (wish us luck) and promenading with the official Pharmalot mascots. What about you? Does spring cleaning beckon? How about finding recession-era bargains at a garage sale? Or maybe take a moment to think big thoughts? Whatever you do, have a great time. And see you soon… Merck Profits Top Estimates (Bloomberg News) Woman Severely Hurt By Abbott Labs Truck (Lake County News-Sun) Johnson & Johnson Prostate Cancer Drug Approved By FDA (Bloomberg News) Generic Lipitor Ruling Expected Next Week (Dow Jones) FDA Panel Recommends Vertex Hepatitis C Drug (Boston Globe) Wolter Kluwers Buy... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=4768250 Fri, 29 Apr 2011 11:48:24 +0100 4768250 http://www.medworm.com/index.php?rid=4762937&cid=t_119684_150_f&fid=35777&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FPharmalot%2F%7E3%2Fhg7QGCQONN0%2F Hello, everyone. Another busy day is about to unfold here on the Pharmalot corporate campus, as we prepare for a round of meetings and deadlines. To cope, we are our brewing our mandatory cup of stimulation - we continue to favor Wild Mountain Blueberry this week. Meanwhile, here are some items to help you get started. Hope your day goes well and stay in touch… Par Pharma Pays $153M To Settle Pricing Lawsuits (Reuters) Sanofi-Aventis Profit Falls Due To Generics (Bloomberg News) More US Women Are Using The Morning After Pill (Reuters) Roche Wins FDA Approval For HPV Diagnostics Test (Bloomberg News) AstraZeneca Profits Get A Lift From Tax Breaks (Pharma Times) Merck Hepatitis C Drug Wins FDA Panel Backing (Boston Globe) Australia Delays Subsidies For Some Medicines (Australian Broadc... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=4762937 Thu, 28 Apr 2011 11:49:06 +0100 4762937 http://www.medworm.com/index.php?rid=4747270&cid=t_119684_139_f&fid=38879&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FVirologyBlog%2F%7E3%2F9ScghR9Ji_c%2F Hosts: Vincent Racaniello, Alan Dove, and Rich Condit Vincent, Alan, and Rich discuss growth in culture of newly identified rhinovirus C, vaccinia transmission among wrestlers and martial artists, and results of phase III clinical trial of boceprevir, a new inhibitor of hepatitis C virus replication. Click the arrow above to play, or right-click to download TWiV #130 (45 MB .mp3, 93 minutes). Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app. Links for this episode: Growth of newly identified rhinovirus C (Nature Medicine) Global distribution of rhinovirus C (EID) Vaccinia transmission among wrestlers (EID) Vaccine transmission in a martial arts gym (EID) Boceprevir for untreated HCV in... virology blog blogs http://www.medworm.com/rss/comments.php?id=4747270 Sun, 24 Apr 2011 14:40:35 +0100 4747270 http://www.medworm.com/index.php?rid=4677109&cid=t_119684_150_f&fid=35777&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FPharmalot%2F%7E3%2Fr0Fv99YQmK0%2F Rise and shine, everyone. Another day is on the way. And it is a sunny one here on the Pharmalot corporate campus, where the short people have left for the local school house and the official Pharmalot mascots are barking at squirrels. You know what this means - it is time for a cup of stimulation. Our flavor today is Southern Pecan. Please join us as we scour the news of the world. Have a great day and do send us those interesting tidbits…. Gilead Raises Prices Of Top-Selling Meds (Dow Jones) J&J Hepatitis C Drug Price Sparks Concern In France (Bloomberg News) Bayer To Consolidate And Add Jobs In New Jersey (The Daily Record) Brand And Generic Makers Clash Over Canada/EU Trade Deal (Pharma Times) Cubist Shares Jump On Teva Patent Deal (Associated Press) Link Sought Between Lab ... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=4677109 Tue, 05 Apr 2011 12:09:01 +0100 4677109 http://www.medworm.com/index.php?rid=4636109&cid=t_119684_139_f&fid=38879&url=http%3A%2F%2Ftraffic.libsyn.com%2Ftwiv%2FTWiV121.mp3 Hosts: Vincent Racaniello, Michael Katze, Michael Gale, Deborah Fuller, and Shawn Iadonato Episode #121 of the podcast This Week in Virology is a conversation about careers in virology, systems biology, innate immunity, and antiviral research recorded at the University of Washington in Seattle. Download TWiV #121 (65 MB .mp3, 90 minutes). To download, right-click or control-click on the link, then select save as. Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with the Microbeworld app. Links for this episode: A systems biology approach to infectious disease research (mBio) Infectious Curiosity (thanks, Gopal!) Astronomy Cast (thanks, Jacob!) The Journal of Negative Results (thanks, Patricia!) Scientist Solutions... virology blog blogs http://www.medworm.com/rss/comments.php?id=4636109 Sun, 20 Feb 2011 23:23:10 +0100 4636109 http://www.medworm.com/index.php?rid=4281552&cid=t_119684_150_f&fid=35777&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FPharmalot%2F%7E3%2FXw5i4ajxIVo%2F Hello, everyone, and top of the morning to you. Another shiny day is unfolding here on the Pharmalot corporate campus, where we are scrambling to do too many things at once. Sounds familiar, yes? To cope, we are quaffing yet another cup of stimulation. Meanwhile, here are some tidbits to help you along. Hope your day is productive and do stay in touch… Arena To Refile Obesity Drug By End Of 2011 (Reuters) Biogen And Elan Want To Update Tysabri Label (Bloomberg News) J&J Shareholders File Suit Over Manufacturing Gaffes (Bloomberg News) Novo Sales Rep Sues For Wrongful Termination (West Virginia Record) Teva And Takeda Settle Actos Patent Lawsuit (Reuters) Vertex Ends Part Of Telaprevir Study For Hepatitis C (Bloomberg News) Pharmacist Jailed For Mail Fraud (Standard Speaker) (Sou... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=4281552 Wed, 22 Dec 2010 13:17:56 +0100 4281552 http://www.medworm.com/index.php?rid=4119716&cid=t_119684_150_f&fid=35777&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FPharmalot%2F%7E3%2F_uKvTFMX99I%2F Rise and shine, everyone. Another day beckons. And this is a special one here on the Pharmalot corporate campus as the shortest of short people celebrates a birthday. An especially large cup of stimulation is in order…among other things. While we fuss, please enjoy these items and, of course, we hope your weekend is wonderful. Whether you pick a pumpkin, rake some leaves, read a book or enjoy a walk, do enjoy yourselves. See you soon… Glaxo Licenses Amicus Therapeutics’ Fabry Drug (Reuters) Sanofi-Aventis Buys A Chinese OTC Maker (Associated Press) Glaxo Cuts Prices In Indonesia By Up To 50 Percent (Reuters) Hepatitis C Is Fertile Field For Blockbusters (The Wall Street Journal) Supreme Court To Review Roche And Stanford Dispute Today (The Tech) AstraZeneca And Daiichi Sign $... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=4119716 Fri, 29 Oct 2010 11:35:14 +0100 4119716 http://www.medworm.com/index.php?rid=4025781&cid=t_119684_151_f&fid=35805&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Ftwelvestepfacilitation%2FwAgT%2F%7E3%2Fca7eOYibSuM%2F DISCUSSION: Brief treatment addressing heavy drinking delivered by hepatitis clinicians with psychiatric-specialist follow-up was associated with abstinence or a significant reduction in alcohol consumption in over 50% of patients. Eric Dieperink, M.D., Samuel B. Ho, M.D., Sara Heit, M.S., R.N., C.N.S., Janet M. Durfee, R.N., M.S.N., APRN, Paul Thuras, Ph.D., and Mark L. Willenbring, M.D. Psychosomatics 51:149-156, March-April 2010 See also Hepatitis C – Does sexual transmission occur? Counselor Magazine’s Addiction Professional Reference Guide Disturbing Denial Improving Treatment Compliance Wernicke-Korsakoff Syndrome Random ArticlesRecovering Alcoholics Effective in Helping OthersFamilies, mental health & alcohol abuseAlcohol Across the LifespanBrief-TSF DescriptionPrinci... Twelve Step Facilitation.com blogs http://www.medworm.com/rss/comments.php?id=4025781 Thu, 30 Sep 2010 07:04:14 +0100 4025781 http://www.medworm.com/index.php?rid=3946690&cid=t_119684_150_f&fid=35777&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FPharmalot%2F%7E3%2FhQAvUYTu_zk%2F Hello, everyone, nice to see you again. A sunny day is dawning here on the Pharmalot corporate campus, where the short people are off to the schoolhouse for another year of adventure and, hopefully, a little learning. While we ponder the possibilities, please join us for another cup of stimulation and a quick scan of the news of the world. Hope your day goes well… Glaxo Hires Goldman Sachs Banker as CFO (Reuters) Business Confidence Is Higher In Pharma Sector (PharmaTimes) Biovail And Valeant Merger To Increase Layoffs (The Globe & Mail) Teva & Baxter Must Pay $365M To Man Infected With Hepatitis C (Ha’aretz) Clinical Trials Initiated In South Korea Rose 150% Since 2006 (OutsourcingPharma) Shanghai Pharma Plans $1.2B IPO (Reuters) Glaxo And Lonza Sign Development Deal... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=3946690 Wed, 08 Sep 2010 12:00:05 +0100 3946690 http://www.medworm.com/index.php?rid=3943023&cid=t_119684_150_f&fid=35777&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FPharmalot%2F%7E3%2F02xdFtqOdnU%2F Continuing its string of pearls philosophy, Bristol-Myers Squibb has agreed to pay in cash for ZymoGenetics, which is developing a hepatitis C compound that was the focus of a collaboration between the two companies beginning early last year. The move is a bid by the big drugmaker, of course, to strengthen its pipeline for hepatitis C, which is forecast to a grow into a multi-billion dollar market. At the moment, the focus is largely on forthcoming treatments from Vertex Pharmaceuticals and Johnson & Johnson, which are in a race with Merck to sell the most effective new protease inhibitor to treat the affliction (see this and this). By acquiring ZymoGenetics, Bristol-Myers gets pegylated-interferon lambda, a novel interferon in Phase IIb, along with several other early-stage treatment... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=3943023 Tue, 07 Sep 2010 22:16:51 +0100 3943023 http://www.medworm.com/index.php?rid=3935736&cid=t_119684_139_f&fid=38879&url=http%3A%2F%2Fmedia.rawvoice.com%2Fpmn_twiv%2Fwww.twiv.tv%2FTWiV097.mp3 Hosts: Vincent Racaniello, Peter Sarnow, and Bert Semler On episode #97 of the podcast This Week in Virology, Vincent visited Peter Sarnow and Bert Semler during a trip to California, and spoke with them about their work on internal ribosome entry, and the requirement for a cellular microRNA for hepatitis C virus replication. Download TWiV #97 (66 MB .mp3, 91 minutes) Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio. Links for this episode: Eukaryotic mRNAs that might contain an IRES (PNAS) Modulation of HCV RNA abundance by a liver-specific microRNA (Science) Viral small RNAs (PLoS Pathogens) Bridging IRES elements to the translation apparatus (Biochim Biophys Acta) A nucleo-cytoplasmic SR pro... virology blog blogs http://www.medworm.com/rss/comments.php?id=3935736 Sun, 05 Sep 2010 22:18:41 +0100 3935736 http://www.medworm.com/index.php?rid=3854751&cid=t_119684_150_f&fid=35777&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FPharmalot%2F%7E3%2F6lHm55SyF5E%2F Good morning, everyone. Another balmy day on the Pharmalot corporate campus, where we are doing our best to keep cool. We trust you are doing the same. Meanwhile, deadlines and meetings continue to loom. As we prepare, please join us for a cup of stimulation and a bottle of water - a chaser, now and then, is a good thing. Have a great day and stay in touch… SciClone Probed By SEC & DOJ Over Activities In China (MarketWatch) WHO Declares Swine Flu Pandemic Is Over (Bloomberg News) Vertex Hepatitis C Drugs Work In Most Patients In 24 Weeks (Reuters) Merck Reacquires Pennsylvania Plant (The Daily Item) Looking For Clues Of Cognitive Impairment With Parkinson’s (The Wall Street Journal) Elan Delays Sale Of Drug Delivery Unit (Reuters) Roche Uncertain About Partnership For Ovar... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=3854751 Tue, 10 Aug 2010 11:59:33 +0100 3854751 http://www.medworm.com/index.php?rid=3823157&cid=t_119684_150_f&fid=35777&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FPharmalot%2F%7E3%2F_42LoYhw96c%2F Earlier today, Merck touted clinical trial results for its becoprevir hepatitis C treatment, but a quick read of the data is not good news for the big drugmaker. Why? The outcome was good, but everything is relative - the results don’t compare all that favorably to telaprevir, which is being developed by Vertex Pharmaceuticals. How so? Combined with the standard of care, the Merck drug yielded a cure rate of 63 percent to 66 percent in treatment-naive patients, or those never before treated. By comparison, patients receiving only standard care had a 38 percent cure rate. But…and this is a big but… A Vertex study of telaprevir found of treatment-naive patients yielded a 75 percent cure rate when combined with standard are. And telaprevir worked faster - 24 weeks versus 28 ... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=3823157 Wed, 04 Aug 2010 20:33:50 +0100 3823157 http://www.medworm.com/index.php?rid=3823164&cid=t_119684_150_f&fid=35777&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FPharmalot%2F%7E3%2FWoBlYMixdrQ%2F Good morning, all. Nice to you see on what looks to be a sunny day here on the Pharmalot corporate campus. The summer haze may have arrived, but we remain as busy as ever. So please join as we quaff our mandatory cup of stimulation and set out to learn about interesting developments. Hope your day goes well and drop us a line… Dendreon Says Provenge Sales Topped $5M In July (Associated Press) Ockham Strikes Deal For Patient Recruitment In Russia (Outsourcing Pharma) Merck Says Hepatitis C Drug Meets Study Goals (Associated Press) New Zealand Agrees To Improve Access To Drugs (PharmaTimes) Genzyme & Isis Report Positive Cholesterol Drug Results (Associated Press) Merck Downplays Arbitration With J&J (Seeking Alpha) How Lilly Let Telaprevir Slip Away (Xconomy) Pfizer Wins Rul... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=3823164 Wed, 04 Aug 2010 11:41:30 +0100 3823164 http://www.medworm.com/index.php?rid=3648231&cid=t_119684_139_f&fid=38879&url=http%3A%2F%2Fwww.virology.ws%2Ffib60.mp3 When infection with hepatitis C virus goes from acute to chronic, severe liver disease may occur which requires organ transplantation. Nearly 200 million people are chronically infected with HCV, necessitating approaches to preventing and treating infections. No HCV vaccine is available, and current antiviral therapy consists of administration of interferon plus ribavirin, a combination that is effective about half the time and is associated with undesirable side effects. New antiviral compounds that target a viral protease and RNA polymerase are currently in clinical trials may eventually reach the market. But our experience with HIV-1 has shown that combinations of three drugs are the most effective for derailing the emergences of drug resistant viruses. The third target for HCV could be... virology blog blogs http://www.medworm.com/rss/comments.php?id=3648231 Wed, 09 Jun 2010 16:17:13 +0100 3648231 http://www.medworm.com/index.php?rid=3635504&cid=t_119684_139_f&fid=38879&url=http%3A%2F%2Fmedia.rawvoice.com%2Fpmn_twiv%2Fwww.twiv.tv%2FTWiV085.mp3 Hosts: Vincent Racaniello and Michael Gale On episode 85 of the podcast This Week in Virology, Vincent and Michael Gale discuss the origin, pathogenesis, prevention, of hepatitis C virus, and how it evades innate immune responses. This episode is sponsored by Data Robotics Inc. Use the promotion code TWIVPOD to receive $75-$500 off a Drobo. Download TWiV #85 (40 MB .mp3, 56 minutes) Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio. Links for this episode: The Gale Laboratory at the University of Washington Incredible view from the Gale laboratory (jpg) Evasion and disruption of innate immune signalling by hepatitis C and West Nile viruses (review) New potent HCV inhibitor HCV virion and genome s... virology blog blogs http://www.medworm.com/rss/comments.php?id=3635504 Sun, 06 Jun 2010 15:33:31 +0100 3635504 http://www.medworm.com/index.php?rid=3629713&cid=t_119684_111_f&fid=39123&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Fnursingcomments%2Ftdtc%2F%7E3%2FXfqGmbW0ZH4%2F Jaundice           The liver is an extraordinary organ in the human body.  It is vital to our survival and performs several functions.  The liver is located in the upper right hand side of the abdomen and it processes the body’s nutrients.  In addition, this powerhouse organ manufactures bile to help digest fats, synthesizing many important proteins.  Further, the liver breaks down potentially toxic substances into ones that the body can use or excrete.  Finally, it is responsible for regulating blood clotting.  Hepatitis is very simply inflammation of the liver.  Most commonly the disease is caused by viruses, but other known causes could include autoimmune disease, alcohol, drugs or it may be an inherited disease.  Things such as body piercing, unprotected sex and tatt... Nursing Comments blogs http://www.medworm.com/rss/comments.php?id=3629713 Fri, 04 Jun 2010 13:09:34 +0100 3629713 http://www.medworm.com/index.php?rid=3599737&cid=t_119684_150_f&fid=35777&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FPharmalot%2F%7E3%2FyU6Y0CRFAbY%2F Hepatitis C is one of the hottest areas for drug development and Vertex Pharmaceuticals has released a study that gives new hope to patients and investors. The results show its Telaprevir treatment increased the cure rate to 75 percent in a pivotal tiral of previously untreated patients, while also reducing the time needed for treatment. By contrast, the cure rate for patients who received only existing therapies was just 44 percent. Of those who got 12 weeks of telaprevir, 75 percent had a sustained viral response, meaning the virus was not detectable in their blood 24 weeks after completing treatment. That is seen as essentially a cure. The rate was 69 percent for those who got eight weeks of telaprevir (see the statement) “These data support the vision that we have long had for fundam... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=3599737 Wed, 26 May 2010 12:13:21 +0100 3599737 http://www.medworm.com/index.php?rid=3595350&cid=t_119684_139_f&fid=38879&url=http%3A%2F%2Fwww.podtrac.com%2Fpts%2Fredirect.mp3%2Ftwit.cachefly.net%2Ffib0060.mp3 I joined Marc Pelletier on episode 60 of Futures in Biotech for a conversation with Dave Brodbeck, George Farr, and Andre Nantel. We talked about primate face recognition, discovery of a new antiviral compound to treat hepatitis C virus infection, changing the length of a codon from three to four bases, and the sequence of the neanderthal genome. Download FiB #60 (44 MB .mp3, 91 minutes) Video courtesy of Team ODTV Download video (179 MB .mp4) (Source: virology blog) virology blog blogs http://www.medworm.com/rss/comments.php?id=3595350 Tue, 25 May 2010 10:38:37 +0100 3595350 http://www.medworm.com/index.php?rid=3549567&cid=t_119684_150_f&fid=35777&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FPharmalot%2F%7E3%2FI_HEEGxSij0%2F Welcome to the working week. We hope your weekend was pleasant and gave you a chance to refresh. Now, of course, the routine resumes, which means those meetings and deadlines loom once again. To prepare, we have assembled a few interesting items to jumpstart what is, so far, a sunny day. Meanwhile, we will brew yet another cup of stimulation. Have a good one and do stay in touch… NiCox Painkiller Heads For FDA Panel Review (PharmaTimes) Sandoz Building In Denver Catches Fire (The Denver Post) Teva And Baxter To Fight $500M Damages In Propofol Case (Bloomberg News) Spain Should Encourage Docs To Prescribe Generics (PharmaTimes) Cipla Revenue Forecast Misses Target (Bloomberg News) Boehringer Ingelheim To Accelerate M&A In China (Global Times) Merck To Shift India Office To Mumbai... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=3549567 Mon, 10 May 2010 11:33:24 +0100 3549567 http://www.medworm.com/index.php?rid=3542871&cid=t_119684_150_f&fid=35777&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FPharmalot%2F%7E3%2FnFw0fdHNQ8E%2F Teva Parenteral Medicine and Baxter Healthcare Services were ordered to pay more than $5 million after a jury found the companies liable in the first civil trial stemming from Southern Nevada’s hepatitis C outbreak, The Las Vegas Review Journal reports. The jury decided the drugmakers, which sold the propofol sedative, failed to label vials with appropriate warnings and should not have provided large vials of the anesthetic to endoscopy centers. Henry Chanin, 62, and his wife filed suit after he received a colonoscopy in 2006 at a clinic during which he was infected with hepatitis C. The center is one of two Las Vegas clinics linked to an outbreak. The jury awarded $3.25 million to Henry Chanin and $1.85 million to Lorraine Chanin. During the three-week trial, Henry Chanin testified... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=3542871 Fri, 07 May 2010 11:42:48 +0100 3542871 http://www.medworm.com/index.php?rid=3538386&cid=t_119684_150_f&fid=35777&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FPharmalot%2F%7E3%2FllPx_XfK0Cw%2F Hello, everyone. Nice to see you again. A busy day lies ahead and so, as you have come to expect, we are brewing the required cup of stimulation to jumpstart the process. Perhaps you wish to do the same. Meanwhile, we are scouring about for interesting items. Please let us know about anything fascinating you come across. Meanwhile, have a nice day… Cipla And Pfizer In Strategic Talks? (The Economic Times) Bayer Gets Rights To Female Sexual Dysfunction Drug (PharmaTimes) Nestle & Alcon Shareholders Reach Deal In Merger Suit (Read the Order) Wisconsin Town Sues Drugmaker Over Loan (Milwaukee Journal-Sentinel) Hepatitis C Resists Vertex Drug (Bloomberg News) FDA Sends Warning Letters To Roche & Shire (Reuters) Merck Adds Lab To NC Vaccine Facility (The News-Observer) Greek Pri... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=3538386 Thu, 06 May 2010 11:49:15 +0100 3538386 http://www.medworm.com/index.php?rid=3408640&cid=t_119684_151_f&fid=35805&url=http%3A%2F%2Ftwelvestepfacilitation.com%2Freductions-in-drinking-for-hep-c-patients%2F DISCUSSION: Brief treatment addressing heavy drinking delivered by hepatitis clinicians with psychiatric-specialist follow-up was associated with abstinence or a significant reduction in alcohol consumption in over 50% of patients. Eric Dieperink, M.D., Samuel B. Ho, M.D., Sara Heit, M.S., R.N., C.N.S., Janet M. Durfee, R.N., M.S.N., APRN, Paul Thuras, Ph.D., and Mark L. Willenbring, M.D. Psychosomatics 51:149-156, March-April 2010 See also Hepatitis C – Does sexual transmission occur? Counselor Magazine’s Addiction Professional Reference Guide Disturbing Denial Improving Treatment Compliance Wernicke-Korsakoff Syndrome Related Reading: Share/SaveRandom ArticlesPatient Mental Illness in a Dental School ClinicComorbid anxiety or alcohol disorderAA and recovery from alc... Twelve Step Facilitation.com blogs http://www.medworm.com/rss/comments.php?id=3408640 Fri, 26 Mar 2010 09:34:46 +0100 3408640 http://www.medworm.com/index.php?rid=3262754&cid=t_119684_123_f&fid=39041&url=http%3A%2F%2Fdrnabong.blogspot.com%2F2010%2F02%2Fhepatitis-c.html This is a virus that is indistinguishable from the signs and symptoms of Hepatitis A and B. The only way to differentiate this is to obtain a blood work for the hepatitis panel.Signs and Symptoms:fevermalaiseanorexianauseavomitingjaundicehepatitisasymptomaticThey noticed that jaundice secondary to Hepatitis C occurs less than 20% of the time and abnormalities in liver function is less pronounced as compared to Hepatitis B. Persistent infection in children occur 50-60% of the time but most children are asymptomatic. Studies on therapy has been limited and the available mode of treatment is only effective half of the time. With advancing age people who have chronic hepatitis C infection are a a risk of developing chronic hepatitis and possible cirrhosis or hepatocellular carcinoma. Children ... Dr Nabong's Pediatric Blogs blogs http://www.medworm.com/rss/comments.php?id=3262754 Wed, 10 Feb 2010 16:36:00 +0100 3262754 http://www.medworm.com/index.php?rid=3153649&cid=t_119684_151_f&fid=35818&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FRecoveryIsSexycom%2F%7E3%2FiLoNIU_9hRs%2F Hepatitis C is a liver disease caused by the hepatitis C virus (HCV). People usually become infected after coming in contact with blood from an infected person. Sharing needles or other equipment for injecting drugs is the most common way of spreading HCV. The disease also can be spread by sexual contact. About 4 million people in the [...] (Source: Recovery Is Sexy.com) Recovery Is Sexy.com blogs http://www.medworm.com/rss/comments.php?id=3153649 Thu, 07 Jan 2010 13:20:57 +0100 3153649 http://www.medworm.com/index.php?rid=2950995&cid=t_119684_150_f&fid=35777&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FPharmalot%2F%7E3%2FGLpICeeuy88%2F Welcome back. We hope your weekend was fun. After all, there was Halloween and the World Series for baseball fans. And there was plenty of opportunity to get some exercise raking leaves, at least for those who live in the US Northeast. Now, though, another week beckons. And so as you prepare for those meetings and deadlines, here are a few items to help you along. Have a nice day everyone… Will Pfizer Buy Protalix? (Globes) Amylin And Takeda To Develop Obesity Drugs (Reuters) Dendreon Seeks FDA Approval For Provenge Vaccine (Reuters) Human Genome Sciences’ Lupus Drug Cuts Symptoms (Bloomberg) Schering-Plough Reports Hepatitis C Drug Results (Associated Press) Vertex Pitches Its Hepatitis C Drug (The Boston Globe) (Source: Pharmalot) Pharmalot blogs http://www.medworm.com/rss/comments.php?id=2950995 Mon, 02 Nov 2009 12:21:12 +0100 2950995 http://www.medworm.com/index.php?rid=2931290&cid=t_119684_150_f&fid=35777&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FPharmalot%2F%7E3%2FWCsYDfXmScc%2F Good morning, everyone. Nice to see you again. The rain clouds are hovering over the Pharmalot corporate campus, but our spirits are sunny. And why not? We are here to enjoy another day and that counts for a lot. So while we reach for another cup of stimulation, here are some of the latest items to help you on your way. Hope your day is swell… FDA Approves Glaxo & Genmab Leukemia Drug (Reuters) ZymoGenetics Gets $70M For Starting Hep C Study (Associated Press) Arena Tries To Position Its Obesity Pill (Xconomy.com) (Source: Pharmalot) Pharmalot blogs http://www.medworm.com/rss/comments.php?id=2931290 Tue, 27 Oct 2009 12:06:52 +0100 2931290 http://www.medworm.com/index.php?rid=2605911&cid=t_119684_86_f&fid=36669&url=http%3A%2F%2Ffadelibrary.wordpress.com%2F2009%2F07%2F16%2Fhepatitis-c-out-of-control-an-audit-of-strategic-health-authority-hepatitis-c-governance%2F Title: Hepatitis C – Out of Control: An audit of Strategic Health Authority hepatitis C governance The Skinny: Audit from the Hepatitis C Trust that identifies that a large majority (70%) of Strategic Health Authorities (SHAs) in England are failing to oversee the Government’s strategy to tackle hepatitis C.  The result of the audit is that the Trust calls for: A national liver czar responsible for driving forward improvements in liver services, particularly hepatitis C. A national liver strategy to address the growing crisis of liver disease, with clearly defined actions for addressing hepatitis C. A robust governance structure for hepatitis C to oversee the monitoring, benchmarking and evaluation of actions by all levels of the NHS. These should be reported annually in the HPA ... Fade Library blogs http://www.medworm.com/rss/comments.php?id=2605911 Thu, 16 Jul 2009 11:18:07 +0100 2605911 http://www.medworm.com/index.php?rid=2144455&cid=t_119684_86_f&fid=36669&url=http%3A%2F%2Ffadelibrary.wordpress.com%2F2009%2F01%2F29%2Fhepatitis-c-quick-reference-guide-for-primary-care-2009-edition%2F in two sides of A4 provides information and good practice advice about hepatitis C testing and diagnosis for use by doctors and nurses in primary care. It includes a testing and diagnosis flowchart. It supersedes the 2007 version. For the public there is the leaflet Hepatitis C: Get tested. Get treated. Posted in Grey Literature, Hepatitis, NHS, Primary Care   Tagged: Diagnosis, Good Practice, Grey Literature, Hepatitis C, Patient Information, Primary Care    (Source: Fade Library) Fade Library blogs http://www.medworm.com/rss/comments.php?id=2144455 Thu, 29 Jan 2009 16:44:08 +0100 2144455 http://www.medworm.com/index.php?rid=2040408&cid=t_119684_150_f&fid=35777&url=http%3A%2F%2Ffeeds.feedburner.com%2F%7Er%2FPharmalot%2F%7E3%2F485487340%2F Welcome back. We hope your weekend was enjoyable, or at least relaxing. Now, of course, the routine returns. And as always, there is much to do. So grab your morning coffee, or whatever, and dig in. Have a good day, everyone… Par Pharmaceutical CFO Resigns (Yahoo/AP) Schering-Plough Hepatitis C Drug Approved For Kids (Yahoo/AP) Bayer To Increase R&D Spending (PharmaTimes) Bristol, Sanofi Win Plavix Patent Battle (Bloomberg News) (Source: Pharmalot) Pharmalot blogs http://www.medworm.com/rss/comments.php?id=2040408 Mon, 15 Dec 2008 12:04:05 +0100 2040408 http://www.medworm.com/index.php?rid=1911300&cid=t_119684_86_f&fid=36669&url=http%3A%2F%2Ffadelibrary.wordpress.com%2F2008%2F10%2F27%2Fhepatitis-c-quick-reference-guide-for-primary-care%2F is a single sheet of concise information and good practice advice about hepatitis C testing and diagnosis for use by doctors and nurses in primary care, including a testing and diagnosis flowchart. Posted in Grey Literature, Hepatitis, NHS, Primary Care, Quality   Tagged: Diagnosis, Evidence Based Practice, Grey Literature, Hepatitis C, Primary Care    (Source: Fade Library) Fade Library blogs http://www.medworm.com/rss/comments.php?id=1911300 Mon, 27 Oct 2008 19:18:13 +0100 1911300 http://www.medworm.com/index.php?rid=1396302&cid=t_119684_136_f&fid=35300&url=http%3A%2F%2Fwww.metastaticlivercancer.org%2F2008-04-24-cancer-treatment%2Fmangosteen-against-metastatic-liver-cancer%2F We got a comment from Nancy, promoting magosteen against cancer at Primary and secondary liver cancer treatments. If you want to promote anything that works 100% against metastatic liver cancer, please let us know and we will add it for FREE. Otherwise please spend $10, click here and put your link instantly. Nancy’s liver cancer story My grandmother died of liver cancer in 1990 -no drinking, no hepatitis C. She went really fast. I’m glad that there’s a blog like this getting the information out there on different treatments. Anyhow, I have heard of many people having luck with the original whole fruit mangosteen juice, which has natural anti-cancer and anti-inflammatory properties. I wish my grandmother could have tried it. Metastatic liver cancer prevention Being awa... Metastatic liver cancer blogs http://www.medworm.com/rss/comments.php?id=1396302 Thu, 24 Apr 2008 09:44:13 +0100 1396302 http://www.medworm.com/index.php?rid=1149828&cid=t_119684_150_f&fid=35777&url=http%3A%2F%2Ffeeds.feedburner.com%2F%7Er%2FPharmalot%2F%7E3%2F216631949%2F The hepatitis C wars between the two drugmakers have been percolating for a few years, but Roche took a harsh swipe after its rival released the results of a study indicating fewer patients receiving its Peg-Intron combo therapy relapsed after the end of treatment. The trial compared two different dosing regimens with Roche’s Pegasys. “With these results, we now have, for the first time, a large body of well-controlled clinical data demonstrating how the similarities and differences of the two leading combination therapies for hepatitis C affect outcomes for patients,” Robert Spiegel, chief medical officer and senior vice president at Schering-Plough Research Institute, crowed in a statement. Roche quickly issued its own statement and accused Schering-Plough of “cle... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=1149828 Mon, 14 Jan 2008 20:26:02 +0100 1149828 http://www.medworm.com/index.php?rid=1111888&cid=t_119684_133_f&fid=35096&url=http%3A%2F%2Ffeeds.b5media.com%2F%7Er%2Fb5media%2FAutismVox%2F%7E3%2F204129267%2F Of the many books about autism published this year, Louder Than Words: A Mother’s Journey in Healing Autism by Jenny McCarthy must have sold the most copies. McCarthy appeared on every major TV talk show from Oprah to Good Morning America to Larry King and the book was on the New York Times bestseller list for quite a while. I’ve written a number of posts already on McCarthy—-Jenny, We Hardly Knew Ye and The New McCarthyism—and heard her interviewing parents at the National Autism Association conference in Atlanta in November. Having read McCarthy’s book, I wish to point out an error in one passage that is emblematic of McCarthy’s rather haphazard use of facts and information in her account of how she “recovered” her son Evan from autism. H... Autism Vox blogs http://www.medworm.com/rss/comments.php?id=1111888 Fri, 21 Dec 2007 16:30:07 +0100 1111888 http://www.medworm.com/index.php?rid=623476&cid=t_119684_87_f&fid=34865&url=http%3A%2F%2Fwww.thecancerblog.com%2F2007%2F05%2F18%2Fhep-c-and-non-hodkins-lymphoma-a-connection%2F Filed under: Non-Hodgkins Lymphoma, Liver Cancer, Daily newsIf living with Hepatitis C isn't trying enough, studies are showing that people living with the chronic condition are at a greater risk for developing Non-Hodgkin's Lymphoma, based on research done on US soldiers living with Hep C. Hep C is a disease characterized by an inflamed liver, and it has also been linked to Liver Cancer. There's no vaccine, and it's spread by an exchange of bodily fluids. The immune system of people living with chronic Hep C is constantly taxed, and it's believed this is the reason behind the link between these two diseases. Hep C, as the article points out, affects more than four million people in the United States, and afflicts men more than women.Read | Permalink | Email this |... The Cancer Blog blogs http://www.medworm.com/rss/comments.php?id=623476 Fri, 18 May 2007 04:00:00 +0100 623476