MedWorm provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest medical blog items that have been tagged with 'ideation'. Sat, 03 Sep 2011 02:17:52 +0100 http://www.medworm.com/index.php?rid=4159500&cid=t_106377_150_f&fid=35777&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FPharmalot%2F%7E3%2F59g-zKJrLv0%2F Whether the Accutane acne med is capable of causing someone to attempt suicide has been a long-standing debate. Severe acne, after all, is known to be very disturbing, suggesting some Accutane patients may already be disposed to consider suicide. Yet a sure-fire scientific link has been lacking. Now, a new study in BMJ, while not offer such a link, nonetheless, suggests the possibility exists. The study examined 5,756 patients between 15 and 49 years old who were prescribed Accutane for severe acne between 1980 and 1990. Ultimately, 128 patients were admitted to a hospital for attempted suicide on 210 occasions and 24 patients committed suicide. After parsing the data and weighing the confounding scenarios, the researchers concluded an increased risk of attempted suicide with Roche’... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=4159500 Fri, 12 Nov 2010 15:41:37 +0100 4159500 http://www.medworm.com/index.php?rid=4003436&cid=t_106377_150_f&fid=35777&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FPharmalot%2F%7E3%2FebX3i3LnNno%2F Suicide has become a big issue in drug development in recent years. Consider the controversy over links to various antidepressants, notably in youngsters, and then the spate of reports involving meds for epilepsy, obesity, acne and smoking cessation (see here, here, here and here). The FDA, however, is concerned the signals largely stemmed from retrospective meta-analyses and spontaneous adverse event reports. And so the agency is considering a more deliberate approach toward clinical study and has issued a guidance with this explanation: “Given the wide range of drugs involved, it is reasonable to consider whether prospective assessments for suicidality should be included in clinical trials involving at least selected drugs for non-psychiatric indications.” “There are tw... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=4003436 Mon, 27 Sep 2010 13:02:45 +0100 4003436 http://www.medworm.com/index.php?rid=3603705&cid=t_106377_122_f&fid=35373&url=http%3A%2F%2Fmerzenich.positscience.com%2F%3Fp%3D251 I had the great pleasure of attending a symposium held in the College of Education at my alma mater, the University of Portland, focused on this interesting subject, and the implications that it bears for effective learning and teaching. My co-participants were distinguished professors in linguistics and education science (Ellyn Arwood and Richard Christen), and [...] (Source: On the Brain by Dr. Michael Merzenich, Ph.D.) On the Brain by Dr. Michael Merzenich, Ph.D. blogs http://www.medworm.com/rss/comments.php?id=3603705 Wed, 26 May 2010 20:27:55 +0100 3603705 http://www.medworm.com/index.php?rid=2463201&cid=t_106377_133_f&fid=35129&url=http%3A%2F%2Fwhitterer-autism.blogspot.com%2F2009%2F06%2Flaws-of-physics-kirby.html Hosted by "Tracy" at "Mother May I," but the photo-picture below will whizz you right there with one click.Happy!Today I have to spotlight my daughter, a tiny icon. You may remember that we had a "breakthrough" around here when my son decided that he both could and would draw, freely. It was pretty momentus for us.His birthday was just around the corner and we take presents pretty seriously. We both favour the hand made kind of gift, the ones that take very little money but do require a great deal of thinking time and effort.So this is a magical feat of artistry to me. He drew the pictures and his big sister transferred the images to the computer, coloured them in and then transferred them onto a t-shirt.The gift was a hit. He was both mystified and delighted. that was the real gift, the ... Whitterer on Autism blogs http://www.medworm.com/rss/comments.php?id=2463201 Mon, 08 Jun 2009 06:25:00 +0100 2463201 http://www.medworm.com/index.php?rid=2324223&cid=t_106377_133_f&fid=35129&url=http%3A%2F%2Fwhitterer-autism.blogspot.com%2F2009%2F03%2Fsuperheroes.html Guess what we watched this weekend?If you enjoy caption competitions and photographs, you may wish to nip along to"DJ Kirkby" over at "Chez Aspie" and test your brain power.Meanwhile I'm still struggling with international postage rates as $45 to the UK is daylight robbery as far as I'm concerned. I may have to limit myself to the good ole US of A initially and expose myself as the tendentious, ethnocentric nincompoop that I really am!If you like what you read, send it to someone in 'need.' (Source: Whitterer on Autism) Whitterer on Autism blogs http://www.medworm.com/rss/comments.php?id=2324223 Wed, 01 Apr 2009 06:38:00 +0100 2324223 http://www.medworm.com/index.php?rid=2200639&cid=t_106377_133_f&fid=35129&url=http%3A%2F%2Fwhitterer-autism.blogspot.com%2F2009%2F02%2Fautocue-spoonfeeding.html Sometimes it seems as if we have been going to occupational therapy forever, certainly more than five years. Together, the boys had 13 hours of different therapies a week up until the time that I had jaw surgery. At that time we dropped everything except for the two double therapy sessions on a Wednesday afternoon, double occupational therapy and double speech therapy because Wednesdays are a half day at school. Their "father" took them during my period of recouperation. It gave him a far deeper "understanding" and greater "involvement" such that when I had recovered and was ready to take up the reins again, he decided that he’d prefer to keep taking them himself. These days I take them occasionally when his schedule doesn’t allow him to go, like when he is abroad on business. Hence wh... Whitterer on Autism blogs http://www.medworm.com/rss/comments.php?id=2200639 Fri, 20 Feb 2009 07:11:00 +0100 2200639 http://www.medworm.com/index.php?rid=2110691&cid=t_106377_133_f&fid=35129&url=http%3A%2F%2Fwhitterer-autism.blogspot.com%2F2009%2F01%2Fwanton-acts-of-violence.html Get the code:-Cut and pastefrom this littleboxy thing below This is what I found first thing yesterday morning at 5:10 a.m.I really wanted to be angry as they were new for Christmas and it’s a bit nippy around here in the mornings.I was secretly pleased as it’s a rare thing for anyone to voluntarily pick up a pair of scissors and use them as a tool purposefully.I decided I would attempt a minor correction to this behaviour so that it doesn’t become a trend.When I approached him he was so excited and chatterful that it was hard to get a word in edgeways, let alone an admonition. Eventually after a great deal of gamboling he was able to show me how he had copied the illustration from his game:- Pokemon Ranger Kellen. They could almost be twins! I did wonder why he was voluntarily dres... Whitterer on Autism blogs http://www.medworm.com/rss/comments.php?id=2110691 Sat, 17 Jan 2009 07:57:00 +0100 2110691 http://www.medworm.com/index.php?rid=2081152&cid=t_106377_133_f&fid=35129&url=http%3A%2F%2Fwhitterer-autism.blogspot.com%2F2009%2F01%2Fnow-thats-not-normal-but-what-is-these.html We all begin to adjust to our "new arrival" in our own individual ways. In the aftermath of the festive season there is a more than usual amount of messiness around. I warn everyone that things left about are likely to be chewed, or if they’re very unlucky, eaten. As usual, no-one pays any heed. I list a lengthy record of similar occurrences that they have each directly experienced with other people’s dogs in the recent and not so recent past. My list and the repeats of my list, sound like my own silent solo. A scratched record.I prepare mentally for the first casualty. Which child victim? Which precious toy? I don’t need to wait long.I gallop at the first scream of agony.In the family room I find my son knelt on the floor before the dog with his hands under his muzzle, “dwop it "F... Whitterer on Autism blogs http://www.medworm.com/rss/comments.php?id=2081152 Mon, 05 Jan 2009 07:52:00 +0100 2081152 http://www.medworm.com/index.php?rid=1509067&cid=t_106377_150_f&fid=35777&url=http%3A%2F%2Ffeeds.feedburner.com%2F%7Er%2FPharmalot%2F%7E3%2F309981177%2F For the past two weeks, reports surfaced that drugmakers are trying to come to grips with FDA plans to increase warnings on 11 epilepsy meds about suicidal thoughts and behavior. One agency official cited a combined analysis of 199 clinical trials that included 43,892 patients showing an “across the board” trend in differences in behavior between patients on placebo and those on the meds. Now, though, a May 23 FDA report, which will be discussed at a July 10 advisory committee, was posted on the agency web site today. The conclusion, of course, has been well telegraphed: “antiepileptic drugs are associated with increased risk of suicidality relative to placebo in randomized placebo-controlled trials. The effect appears consistent among the group of 11 drugs.” For th... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=1509067 Wed, 11 Jun 2008 23:00:43 +0100 1509067 http://www.medworm.com/index.php?rid=1223813&cid=t_106377_150_f&fid=35777&url=http%3A%2F%2Ffeeds.feedburner.com%2F%7Er%2FPharmalot%2F%7E3%2F233402093%2F For all the puzzling or disturbing stories about the Pfizer smoking-cessation drug, the details have usually been restricted to dry recitation of scientific data and specific, but brief descriptions of strange side effects, predominantly hallucination. However, Derek De Koff, a contributor to New York magazine, writes a lengthy first-person account of what it was like to take the controversial med. And the tale he tells is troubling, especially given that the FDA recently upgraded warnings about suicidal behavior amid reports of 34 suicides. Here are a few excerpts… “The most unsettling thing about sleeping on Chantix is that I never felt like I was truly asleep. Some part of me remained on guard. It was more like lucid dreaming, what I thought it might feel like to be hypnoti... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=1223813 Mon, 11 Feb 2008 22:04:18 +0100 1223813 http://www.medworm.com/index.php?rid=1194996&cid=t_106377_150_f&fid=35777&url=http%3A%2F%2Ffeeds.feedburner.com%2F%7Er%2FPharmalot%2F%7E3%2F227458487%2F The FDA has announced a public health advisory about abnormal behavior, agitation, depressed mood, suicidal ideation, and actual suicidal behavior with Pfizer’s anti-smoking drug. And has provided updated numbers - 491 cases of suicidal thinking or behavior, including 420 in the US. And of those, there were 39 suicides, including 34 in the US. “We’ve become increasingly concerned as we see a number of cases that truly look like exposure to the drug and not other causes,” says Bob Rappaport, director of the FDA’s division of anesthesia, analgesia and rheumatology products, in a briefing this afternoon with reporters. Pfizer has contended that “some reports may have been complicated by the symptoms of nicotine withdrawal in patients who stopped smoking, b... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=1194996 Fri, 01 Feb 2008 21:15:24 +0100 1194996 http://www.medworm.com/index.php?rid=1174891&cid=t_106377_109_f&fid=34750&url=http%3A%2F%2Fpsychcentral.com%2Fblog%2Farchives%2F2008%2F01%2F24%2Fsuicide-assessment-now-required-in-drug-studies%2F After the well-publicized problems with antidepressants and an increased risk of suicide, the U.S. Food and Drug Administration (FDA) is now requiring pharmaceutical companies to assess and track suicidal ideation during all clinical drug trials. The New York Times has the full story, F.D.A. Requiring Suicide Studies in Drug Trials: The drug agency’s concerns are consistent with a growing body of research confirming that behavior is heavily influenced not only by genes but also by seemingly innocuous changes in body chemistry. Drugs not reaching the brain were once thought to be largely free of mental effects. “One lesson from pharmacology is that you can see effects on emotion and cognition without the drug entering the brain if a drug leads to peripheral changes in” other chemi... World of Psychology blogs http://www.medworm.com/rss/comments.php?id=1174891 Thu, 24 Jan 2008 18:35:11 +0100 1174891 http://www.medworm.com/index.php?rid=1175051&cid=t_106377_150_f&fid=35777&url=http%3A%2F%2Ffeeds.feedburner.com%2F%7Er%2FPharmalot%2F%7E3%2F222264192%2F The new rules represent one of the most profound changes of the past 16 years to regulations governing drug development. But since the F.D.A.’s oversight of experimental medicines is done in secret, the agency’s shift has not been announced publicly, The New York Times reports. The drug industry, however, is keenly aware of the change. Makers of drugs to treat obesity, urinary incontinence, epilepsy, smoking cessation, depression and many other conditions are being asked for the first time by the FDA to put a comprehensive suicide assessment into their trials, the paper writes. In recent months, the FDA sent letters - but wouldn’t say how many - to drugmakers requiring they use such a scale. Merck, Sanofi-Aventis and Eli Lilly are all using a detailed suicide assessment in clini... Pharmalot blogs http://www.medworm.com/rss/comments.php?id=1175051 Thu, 24 Jan 2008 12:31:29 +0100 1175051 http://www.medworm.com/index.php?rid=4060744&cid=t_106377_109_f&fid=34859&url=http%3A%2F%2Fblog.davemsw.com%2Farchives%2F2007%2F09%2Fapproaching_the_challenge_of_bipolar_depression_results_from_step-bd.php There is some major progress in the treatment of persons with Bipolar DO - Mixed episodes. Bipolar DO-Mixed is characterized by less serious manic symptoms, or hypomania, and significant depressive symptoms occuring at the same time. As you might expect, having a high energy level, little impulse control, impaired judgment and significant depression is a miserable condition, prone to substance abuse, suicide ideation and serious attempts. Persons with BPDO-Mixed are more prevalent in my practice than any other subtype of the disorder. That fact could be an artifact of primary finding of the following studies. Anti-depressants, when combined with mood stabilizers such as Lithium or Depakote, or atypical anti-psychotic medications like Abilify or Seroquel have been found to provide no more ... Ψ Dare To Dream... blogs http://www.medworm.com/rss/comments.php?id=4060744 Sat, 22 Sep 2007 03:37:03 +0100 4060744 http://www.medworm.com/index.php?rid=677438&cid=t_106377_109_f&fid=35671&url=http%3A%2F%2Fwww.anxietyinsights.info%2Fdiagnosis_treatment_of_youth_for_depression_fell_after_fda_.htm Eve Bender Researchers are troubled by data indicating that large numbers of young people with depression are being left untreated after the FDA issued its first advisory about the antidepressants in 2003. Rates of the diagnosis and pharmacological treatment of depression among children and adolescents dropped sharply after October 2003, when the U.S. Food and Drug Administration (FDA) issued its first public health advisory informing health care professionals of an increased risk of suicidality among youngsters taking antidepressants. These findings, which appeared in the June American Journal of Psychiatry, have heightened the concerns of researchers and clinicians alike that suicide rates among untreated children and adolescents will rise unchecked. In fact, a study published in the Feb... Latest entries from www.anxietyinsights.info blogs http://www.medworm.com/rss/comments.php?id=677438 Sat, 16 Jun 2007 06:51:00 +0100 677438 http://www.medworm.com/index.php?rid=677457&cid=t_106377_109_f&fid=35671&url=http%3A%2F%2Fwww.anxietyinsights.info%2Fsanofi_says_rimonobant_unsuitable_for_patients_with_major_de.htm PARIS (Thomson Financial) - Sanofi-Aventis has told the US Food and Drug Administration its rimonobant anti-obesity drug, also known under the Acomplia brand, brings a higher risk of suicidal thoughts than placebo and does not recommend the treatment for patients suffering from major depression. More... © 2007 Forbes.com LLC™ All Rights Reserved (Source: Latest entries from www.anxietyinsights.info) Latest entries from www.anxietyinsights.info blogs http://www.medworm.com/rss/comments.php?id=677457 Tue, 12 Jun 2007 00:33:00 +0100 677457 http://www.medworm.com/index.php?rid=659387&cid=t_106377_109_f&fid=35671&url=http%3A%2F%2Fwww.anxietyinsights.info%2Fgene_variations_may_explain_antidepressantsuicidality_link.htm Genetic variations may help explain why some men with depression develop suicidal thoughts and behaviors after they begin taking antidepressant medications, while most do not, according to a report in the June issue of Archives of General Psychiatry, one of the JAMA/Archives journals. Although most patients with depression respond favorably to antidepressant medications, a very small subgroup may experience worse symptoms after beginning treatment, according to background information in the article. "Regardless of treatment specificity, nearly all antidepressant medication studies find that some patients experience suicidality [suicidal thoughts and behaviors] after treatment initiation," the authors write. "Identification of this subpopulation before treatment would have tremendous clinic... Latest entries from www.anxietyinsights.info blogs http://www.medworm.com/rss/comments.php?id=659387 Tue, 05 Jun 2007 08:28:00 +0100 659387 http://www.medworm.com/index.php?rid=651901&cid=t_106377_109_f&fid=35671&url=http%3A%2F%2Fwww.anxietyinsights.info%2Fthe_fda_pediatric_advisories_and_changes_in_diagnosis_and_tr.htm Am J Psychiatry 164:843-846, June 2007 The FDA Pediatric Advisories and Changes in Diagnosis and Treatment of Pediatric Depression Pfeffer CR. Pediatric depression is a national health problem that clinical, research, and public health activities aim to prevent and treat. Naturalistic longitudinal studies have shown correlations between prepubertal depression and high rates of suicidal ideation and behavior, and prepubertal depression has been found to be a predictor of both suicide attempts in adolescence and suicide in young adulthood (1-3). Moreover, the majority of pediatric suicide victims suffer from depression near the time of death (4, 5). Given the inherent relationship between depression and suicidality, close monitoring for recurrences of pediatric depression is essential. Indir... Latest entries from www.anxietyinsights.info blogs http://www.medworm.com/rss/comments.php?id=651901 Fri, 01 Jun 2007 08:27:00 +0100 651901 http://www.medworm.com/index.php?rid=651902&cid=t_106377_109_f&fid=35671&url=http%3A%2F%2Fwww.anxietyinsights.info%2Fabstract_decline_in_treatment_of_pediatric_depression_after.htm CONCLUSIONS: The FDA advisory was associated with significant reductions in aggregate rates of diagnosis and treatment of pediatric depression. (Text has been reformatted for clarity, Emphasis added; ed.) Source... Comment:  It was no surprise that the prescribing of antidepressants to children would fall after the FDA mandated black box warnings in 2004. That children would then not receive alternative treatments may not have been as obvious, but given the difficulties many families would have in accessing the most effective alternative, psychotherapy, either because of a lack of experienced local therapists or the limited number of visits covered by many health insurance plans, perhaps it should have been. The result seems to have been the worst possible outcome - many children left... Latest entries from www.anxietyinsights.info blogs http://www.medworm.com/rss/comments.php?id=651902 Fri, 01 Jun 2007 08:26:00 +0100 651902 http://www.medworm.com/index.php?rid=651915&cid=t_106377_109_f&fid=35671&url=http%3A%2F%2Fwww.anxietyinsights.info%2Fabstract__assessing_the_role_of_drugs_in_suicidal_ideation_.htm CNS Drugs. 2007;21(6):463-72. Assessing the role of drugs in suicidal ideation and suicidality. Reith DM, Edmonds L. Dunedin School of Medicine, University of Otago, Dunedin, New Zealand. The emergence of suicidal ideation and suicide-related behaviour in patients receiving drug treatment is of concern because of the overall burden of these conditions and the possible link with completed suicide. Observational studies have been useful in generating hypotheses of causality but are confounded by the association between various disease states and increased suicide-related behaviour and completed suicide. The demonstration of causality requires experimental studies, especially randomised controlled trials, and meta-analyses. Unfortunately, the lack of uniform requirements for defining, detecti... Latest entries from www.anxietyinsights.info blogs http://www.medworm.com/rss/comments.php?id=651915 Sun, 27 May 2007 08:04:00 +0100 651915 http://www.medworm.com/index.php?rid=494014&cid=t_106377_133_f&fid=35129&url=http%3A%2F%2Fwhitterer-autism.blogspot.com%2F2007%2F03%2Fbasic-principles-of-parenting.html You only need to know one. The one principle that all parents need to know and apply is ‘consistency.’ It’s better for the parent, it’s perfect for the child. If the child happens to be autistic, then woe betide the parent that quibbles with the undoubted soundness of this GOLDEN rule. The parent of the autistic child must apply the same consistent rules to that child several thousands of times, preferably in the same manner to avoid confusion. [most probably of the parent] Should you, the parent, be tempted to deviate from this course, then you only have yourself to blame when the whole house of cards comes crashing down upon your head. I know more than a few parents have difficulty with this first and most basic of steps, but it behoves us all to heed these words well. There can ... Whitterer on Autism blogs http://www.medworm.com/rss/comments.php?id=494014 Fri, 23 Mar 2007 02:40:00 +0100 494014