MedWorm provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest medical blog items that have been tagged with 'integrase'. Sat, 03 Sep 2011 02:38:46 +0100 http://www.medworm.com/index.php?rid=3287420&cid=t_151834_139_f&fid=38879&url=http%3A%2F%2Fwww.virology.ws%2F007_W3310_10.wmv Download: .wmv (354 MB) | .mp4 (92 MB) Visit the virology W3310 home page for a complete list of course resources. (Source: virology blog) virology blog blogs http://www.medworm.com/rss/comments.php?id=3287420 Thu, 18 Feb 2010 18:44:13 +0100 3287420 http://www.medworm.com/index.php?rid=3231754&cid=t_151834_135_f&fid=35247&url=http%3A%2F%2Fmyjourneywithaids.wordpress.com%2F2010%2F02%2F02%2Fa-major-breakthrough-in-the-still-mysterious-to-me-web-of-hivaids-research%2F I didn’t have the radio or television on Monday so I nearly missed this – what, to this layman anyway, has remained such a mystery since the early, crudest diagrams of the virus first appeared. I am still doing okay on protease inhibitors Prezista (and one of the originals Norvir) and a nucleoside (yes it’s a [...] (Source: My journey with AIDS) My journey with AIDS blogs http://www.medworm.com/rss/comments.php?id=3231754 Tue, 02 Feb 2010 06:49:02 +0100 3231754 http://www.medworm.com/index.php?rid=3066735&cid=t_151834_139_f&fid=38879&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2FVirologyBlog%2F%7E3%2FfVPd2Mu0nD4%2F Xenotropic murine leukemia virus related virus (XMRV) has been implicated in prostate cancer and chronic fatigue syndrome (CFS). Because XMRV is a retrovirus, it has been suggested that it might be susceptible to some of the many drugs available for treatment of AIDS. Of ten licensed compounds evaluated for activity against XMRV, just one, AZT (azidothymidine), was found to inhibit viral replication. Compounds used to treat HIV-1 infection fall into distinct classes: protease inhibitors (Ritonavir, Saquinavir, or Indinavir), nucleoside reverse transcriptase inhibitors (NRTI, AZT, 3TC, Tnofovir, D4T), non-nucleoside reverse transcriptase inhibitors (NNRTI, Efavirenz, Nevirapine), integrase inhibitors (118-D-24), and fusion inhibitors (Maraviroc). None of the HIV-1 protease inhibitors, NNRTI... virology blog blogs http://www.medworm.com/rss/comments.php?id=3066735 Tue, 08 Dec 2009 11:00:33 +0100 3066735 http://www.medworm.com/index.php?rid=2862086&cid=t_151834_77_f&fid=37259&url=http%3A%2F%2Fwww.horizonpress.com%2Fblogger%2F2009%2F10%2Freverse-transcription.html Retroviruses are unique among animal viruses in that their replication requires the recombination of their own genetic material with that of the infected host cell. Two virus-encapsulated enzymes, reverse transcriptase and integrase, are dedicated to provirus formation. Reverse transcriptase, using a packaged cellular tRNA primer to initiate DNA synthesis from the viral RNA template, generates linear double-stranded DNA within the context of the reverse transcription nucleoprotein complex. The integrase enzyme processes the neo-synthesised DNA ends as the preintegration complex moves toward the cell nucleus. After finding a suitable chromatin acceptor site, the integrase recombines the processed DNA ends with a cell chromosome. For further details on the mechanisms of viral DNA synthesis, ... Microbiology Blog: The weblog for microbiologists. blogs http://www.medworm.com/rss/comments.php?id=2862086 Mon, 05 Oct 2009 10:58:00 +0100 2862086 http://www.medworm.com/index.php?rid=948591&cid=t_151834_97_f&fid=35050&url=http%3A%2F%2Ffeeds.feedburner.com%2F%7Er%2FPharmaGazette%2F%7E3%2F169476649%2Fmerck_cos_aids_pills_approved_by_fda.html The FDA has approved Merck & Co.'s (NYSE:MRK)newest AIDS option, Isentress and the company said that the pill should be available to the public within the next two weeks.Three different enzymes are used by the AIDS virus to reproduce and infect cells and numerous drugs are available that attack two of those enzymes, protease and reverse transcriptase. Isentress is the first in a new class of medication that blocks the third called integrase. When Isentress (raltegravir) is added to the drug "cocktail", it can lower the amount of HIV in the blood and thus help immune cells rebound. Inhibiting integrase from allowing HIV DNA insertion into human DNA blocks the ability of the virus to replicate and infect new cells.The FDA approved the use of Isentress for use of patien... PharmaGazette blogs http://www.medworm.com/rss/comments.php?id=948591 Sat, 13 Oct 2007 19:36:22 +0100 948591