MedWorm: Cryotherapy

Long-term follow-up of invasive ocular surface squamous cell carcinoma treated with excision, cryotherapy, and topical mitomycin C

Graefe's Archive for Clinical and Experimental Ophthalmology — Thu, 02 Feb 2012 06:54:32 +0100

Conclusion The combination of surgical excision, cryotherapy, and post-operative topical mitomycin-C was effective treatment for ocular surface invasive SCC in long-term follow-up. Content Type Journal ArticleCategory OncologyPages 1-6DOI 10.1007/s00417-012-1931-xAuthors Mohsen Bahmani Kashkouli, Eye Research Center, Rassoul Akram Hospital, Tehran University of Medical Sciences, Sattarkhan-Niayesh Street, Tehran, 14455-364 IranAbtin Heirati, Eye Research Center, Rassoul Akram Hospital, Tehran University of Medical Sciences, Sattarkhan-Niayesh Street, Tehran, 14455-364 IranFarzad Pakdel, Eye Research Center, Rassoul Akram Hospital, Tehran University of Medical Sciences, Sattarkhan-Niayesh Street, Tehran, 14455-364 IranVictoria Kiavash, Eye Research Center, Rassoul Akr...

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Keratotic Horn on Left Fifth Fingertip: Congenital Ectopic Nail Misdiagnosed as a Common Wart

Pediatric Dermatology — Thu, 26 Jan 2012 05:00:00 +0100

Abstract: The term “ectopic nail” refers to nail tissue found in a location other than in the normal nail bed. Here we report a 9‐year‐old girl with an asymptomatic keratotic “horn” on the tip of her left fifth finger. Present since the age of 1 month, it was misdiagnosed as a common wart and treated using liquid nitrogen cryotherapy without benefit. (Source: Pediatric Dermatology)

Video: Cryotherapy of the esophagus

MayoClinic.com Full Feed — Tue, 24 Jan 2012 06:00:00 +0100

Cryotherapy video shows use of extreme cold treatment for Barrett's esophagus and esophageal cancer. (Source: MayoClinic.com Full Feed)

Third-Generation Salvage Cryotherapy for Radiorecurrent Prostate Cancer: A Centre’s Experience

Urologia Internationalis : Last 20 articles — Mon, 23 Jan 2012 23:00:00 +0100

Urol Int (DOI:10.1159/000332220) (Source: Urologia Internationalis : Last 20 articles)

Porokeratosis in Singapore: An Asian perspective

Australasian Journal of Dermatology — Thu, 19 Jan 2012 05:00:00 +0100

ABSTRACTPorokeratosis is a rare disorder of skin keratinisation characterised by a cornoid lamella. We reviewed its associations with immunosuppression and phototherapy, as well as the risks of malignant progression. This is a retrospective review on all cases of porokeratosis seen at the National Skin Centre, Singapore, between 2000 and 2010. A total of 94 patients were reviewed. Clinical and histological diagnoses were confirmed in 63% patients. Most patients were Chinese (89%) with a mean age of 51.6 years. The male to female ratio was 1.4:1. The four main clinical variants were classical porokeratosis of Mibelli (56%), disseminated superficial actinic porokeratosis (DSAP) (18%), disseminated superficial porokeratosis (DSP) (11%), and linear porokeratosis (13%). Phototherapy‐induced...

Topical vitamin A treatment of recalcitrant common warts

Virology Journal — Tue, 17 Jan 2012 05:00:00 +0100

Conclusion: Retinoids should be further investigated in controlled studies to determine their effectiveness in treating common warts and the broad range of other benign and cancerous lesions induced by HPVs. (Source: Virology Journal)

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Imiquimod vs Cryotherapy for Molluscum Contagiosum: A Randomized Controlled Trial [Evidence-Based Dermatology: Research Commentary]

Archives of Dermatology — Mon, 16 Jan 2012 05:00:00 +0100

(Source: Archives of Dermatology)

Histomorphometric assessment of bone necrosis produced by two cryosurgery protocols using liquid nitrogen: an experimental study on rat femurs

Journal of Applied Oral Science — Fri, 13 Jan 2012 21:27:33 +0100

CONCLUSIONS: The present results indicate that the 2-min protocol produced more marked bone necrosis than the 1-min protocol. Although our results cannot be entirely extrapolated to clinical practice, they contribute to the understanding of the behavior of bone tissue submitted to different cycles of liquid nitrogen freezing and may serve as a basis for new studies. (Source: Journal of Applied Oral Science)

Keratocystic Odontogenic Tumors and Carnoy’s Solution: Results and Complications Assessment

Oral Diseases — Tue, 10 Jan 2012 05:00:00 +0100

Conclusions: Complementary treatment with Carnoy’s solution and peripheral ostectomy appear to provide efficient treatment for keratocystic odontogenic tumors. Complications originating from the use of the solution are less frequent and less serious than complications associated with cryotherapy. Neuropathy seems to be related to direct contact between the solution and the epineurium.© 2012 John Wiley & Sons A/S (Source: Oral Diseases)

Procedural Complications, Rehospitalizations, and Repeat Procedures After Catheter Ablation for Atrial Fibrillation

Journal of the American College of Cardiology — Wed, 04 Jan 2012 18:27:39 +0100

Conclusions: Periprocedural complications occurred in 1 of 20 patients undergoing AF ablation, and all-cause and arrhythmia-related rehospitalizations were common. Older age, female sex, prior AF hospitalizations, and recent hospital procedure experience were associated with a higher risk of complications and/or 30-day readmission after AF ablation. (Source: Journal of the American College of Cardiology)

Successful Treatment of Refractory Wart with a Topical Activated Vitamin D in a Renal Transplant Recipient

Clinical and Developmental Immunology — Wed, 04 Jan 2012 14:29:49 +0100

Warts are benign proliferations of the skin and mucosa caused by infection with human papillomavirus. They are commonly treated with destructive modalities such as cryotherapy with liquid nitrogen, local injection of bleomycin, electrocoagulation, topical application of glutaraldehyde, and local and systemic interferon-β therapy. These treatment modalities often cause pain and sometimes scarring or pigmentation after treatment. We herein report a case with a right index finger wart, which was successfully treated with a topical activated vitamin D. (Source: Clinical and Developmental Immunology)

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Endoscopic ablation therapy for gastrointestinal superficial neoplasia

Digestive Endoscopy — Thu, 29 Dec 2011 05:00:00 +0100

Conclusion: Although we should understand that the completeness of destruction of neoplastic tissue can only be judged at follow up, endoscopic ablation is a viable alternative to endoscopic resection for dysplasia and early‐stage malignancies, especially for poor candidates of surgery or endoscopic resection. (Source: Digestive Endoscopy)

Periocular Basal Cell Carcinoma: Nitrous Oxide Cryotherapy Periocular Basal Cell Carcinoma: Nitrous Oxide Cryotherapy

Medscape Today Headlines — Tue, 27 Dec 2011 04:00:00 +0100

Is nitrous oxide cryotherapy an established and trusted way to treat periocular basal cell carcinoma? The British Journal of Ophthalmology (Source: Medscape Today Headlines)

Retrospective study of 25 cases of keratocystic odontogenic tumor: epidemiology and treatment.

J Contemp Dent Pract — Sun, 25 Dec 2011 03:30:05 +0100

Conclusion: Our data analysis showed the importance of previous diagnosis before enucleation procedure and long-term follow-up for recurrence early detection. Recurrence incidence is more frequent on first year after diagnosis. Clinical significance: KOT is a benign tumor with local aggressive behavior and therefore its treatment must consider the high index of recidive. Reports of protocol treatment should raise new discussion to decrease recurrence rates. Keywords: Keratocyst, Odontogenic tumor, Keratocystic odontogenic tumor. How to cite this article: Schussel JL, Stramandinoli RT, Dissenha JL, Avila LFC, Sassi LM. Retrospective Study of 25 Cases of Keratocystic Odontogenic Tumor: Epidemiology and Treatment. J Contemp Dent Pract 2011;12(2):100-103. Source of support: Nil Conflict of int...

Comparative effectiveness of cryotherapy vs brachytherapy for localised prostate cancer

BJU International — Thu, 22 Dec 2011 05:00:00 +0100

CONCLUSIONS• Although less costly, cryotherapy was associated with more urinary and ED complications and greater need for salvage ADT.• Conversely, cryotherapy was associated with fewer bowel complications. Patients and providers alike should consider these population‐based outcomes when discussing therapeutic options for localised prostate cancer. (Source: BJU International)

Depigmentation therapies in vitiligo

Indian Journal of Dermatology, Venereology and Leprology — Sat, 17 Dec 2011 05:00:00 +0100

Divya Gupta, Rashmi Kumari, Devinder Mohan ThappaIndian Journal of Dermatology, Venereology, and Leprology 2012 78(1):49-58Depigmentation therapy in vitiligo is an option in those with extensive vitiligo who have failed to respond to medical therapy and have obvious cosmetic disfigurement due to intervening patchy pigmented areas. Various aspects of this therapy such as the cost, treatment time, course, permanency of depigmentation, side effects, and the possibility of repigmentation should first be discussed with the patient. At present, there is no ideal depigmenting therapy available, but many agents in the market have been in use for many years. Monobenzyl ether of hydroquinone (MBEH) is the mainstay and Food and Drug Administration (FDA) approved in USA but takes many months to depigm...

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Crusted Pustular Lesions After Cryotherapy.

Actas Dermo-Sifiliograficas — Thu, 15 Dec 2011 05:00:00 +0100

Authors: Palomo-Arellano A, Cervigón-González I, Idrovo-Mora F, Torres-Iglesias LM PMID: 22176861 [PubMed - as supplied by publisher] (Source: Actas Dermo-Sifiliograficas)

Complications Associated with Cryotherapy for Prostate CancerComplications Associated with Cryotherapy for Prostate Cancer

Medscape Today Headlines — Tue, 13 Dec 2011 04:00:00 +0100

Which treatment-related complications are associated with cryotherapy for localized prostate cancer? Prostate Cancer and Prostatic Diseases (Source: Medscape Today Headlines)

Cryotherapy Good For Exercise Recovery

Health News from Medical News Today — Fri, 09 Dec 2011 09:00:00 +0100

Athletes go to great lengths to protect their muscles and recover from exercise-induced muscle damage, but there has been little work to determine what methods are most effective. Now, a study published in the online journal PLoS ONE reports that runners benefit more from whole-body cryotherapy, in which the study participants was exposed to temperatures as cold as -166°F (-110°C), than from exposure to far-infrared radiation or no treatment... (Source: Health News from Medical News Today)

Effects of Biofreeze vs. ice on acute, non-complicated neck pain

Clinical Chiropractic — Thu, 01 Dec 2011 05:00:00 +0100

Background: Cryotherapy has long been used by physical therapists and chiropractors in the management of acute pain and more recently it has been shown to effectively manage chronic pain. Multiple studies have demonstrated that both ice and menthol decrease blood flow and help to control pain; however, there is limited research to determine which form of cryotherapy works better on individual patients. (Source: Clinical Chiropractic)

Photodynamic therapy for actinic keratosis in organ transplant patients

Journal of the European Academy of Dermatology and Venereology — Thu, 01 Dec 2011 05:00:00 +0100

Conclusions This position article summarizes those discussions and makes recommendations concerning a standardized protocol for treating OTRs, for a large randomized controlled trial to provide robust data on safety, efficacy and optimal pain control, and to provide pharmaco‐economics data that can be used to support extended reimbursement in this patient group. The authors also recommend a second clinical trial to further investigate induced immunosuppression with PDT in healthy volunteers. (Source: Journal of the European Academy of Dermatology and Venereology)

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Pulmonary Resection for Airway Complication After Lung Transplantation in a Patient with Cystic Fibrosis: A Case Report

Transplantation Proceedings — Thu, 01 Dec 2011 05:00:00 +0100

We report a case of the interdisciplinary management of recurring bronchial stenosis after bilateral sequential single-lung transplantation (BSSLT) in a 35-year-old female with cystic fibrosis. Initial bronchoscopic therapy including balloon dilatation, stenting, and cryotherapy for granulation tissue overgrowth was unsuccessful in maintaining airway patency. In view of the persistent left lower lobe (LLL) atelectasis and fibrosis predisposing to recurrent infections, she was submitted for left lower lobectomy. (Source: Transplantation Proceedings)

Efficacy of Acitretin for Porokeratosis in a Child with Chronic Cutaneous Graft Versus Host Disease

Pediatric Dermatology — Wed, 16 Nov 2011 05:00:00 +0100

Abstract: Porokeratosis is a rare disorder of epidermal keratinization that is regarded as a precancerous. Recipients of hematopoietic stem cell transplantation (HSCT) have a greater risk of skin cancer; chronic graft versus host disease (GVHD) is an additional risk factor. A 16‐year‐old boy who had received HSCT for acute myelogenous leukemia was referred to us for sclerodermoid chronic cutaneous GVHD. Two years later, he developed disseminated porokeratosis with a few atypical lesions. Despite cryotherapy, numerous lesions of porokeratosis recurred rapidly. Acitretin resulted in good clinical response and reduced the rate of onset of new lesions. (Source: Pediatric Dermatology)

Highlights from this issue

British Journal of Ophthalmology — Wed, 16 Nov 2011 05:00:00 +0100

Cryotherapy for periocular basal cell carcinoma Moesen et al report the 5-year outcome of 100 patients with primary periocular basal cell carcinoma treated by cryotherapy (double freeze-thaw cycle). In this prospective, non-comparative, interventional case series, only circumscribed tumours with maximum diameter of 8 mm were included. Histologically proven recurrence rate was 8%. There was no correlation between tumour site, tumour size, cryotherapy freeze time and recurrence. (see page 1679) RNFL and macular thickness in amblyopia Al-Haddad et al studied peripapillary retinal nerve fibre layer (RNFL) and macular thickness in unilateral amblyopia (strabismic or anisometropic) and non-amblyopic anisometropia. SD-OCT measurements were compared with fellow eyes. The mean age was 20 ...

Nitrous oxide cryotherapy for primary periocular basal cell carcinoma: outcome at 5 years follow-up

British Journal of Ophthalmology — Wed, 16 Nov 2011 05:00:00 +0100

Conclusion The results of this series suggest that nitrous oxide probe cryotherapy for primary periocular basal cell carcinomas up to 8 mm diameter has a recurrence rate of ~8%. Cryotherapy has certain advantages over surgical removal of tumours of this size in the periocular region, but careful follow-up is advisable. (Source: British Journal of Ophthalmology)

Cryogun cryotherapy for oral leukoplakia

Head and Neck — Tue, 15 Nov 2011 05:00:00 +0100

ConclusionsFor treatment of oral leukoplakia, the cryogun cryotherapy needed fewer mean treatments to achieve complete regression of the lesions than the cotton‐swab cryotherapy. Head Neck, 2011 (Source: Head and Neck)

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Retrospective study of rhegmatogenous retinal detachments secondary to round retinal holes.

European Journal of Ophthalmology — Thu, 10 Nov 2011 05:00:00 +0100

Conclusions. Retinal detachments secondary to round holes have consistent characteristic features (young, myopic, female, inferior detachment). Surgical management is increasingly advocated and most achieve primary surgical success with a good final visual acuity. PMID: 22081671 [PubMed - as supplied by publisher] (Source: European Journal of Ophthalmology)

Endoscopic management of chronic radiation proctitis.

World Journal of Gastroenterology : WJG — Mon, 07 Nov 2011 05:00:00 +0100

Authors: Rustagi T, Mashimo H Abstract Chronic radiation proctopathy occurs in 5%-20% of patients following pelvic radiotherapy. Although many cases resolve spontaneously, some lead to chronic symptoms including diarrhea, tenesmus, urgency and persistent rectal bleeding with iron deficiency anemia requiring blood transfusions. Treatments for chronic radiation proctitis remain unsatisfactory and the basis of evidence for various therapies is generally insufficient. There are very few controlled or prospective trials, and comparisons between therapies are limited because of different evaluation methods. Medical treatments, including formalin, topical sucralfate, 5-amino salicylic acid enemas, and short chain fatty acids have been used with limited success. Surgical management is asso...

Temperature-sensitive release of prostaglandin e2 and diminished energy requirements in synovial tissue with postoperative cryotherapy: a prospective randomized study after knee arthroscopy.

The Journal of Bone and Joint Surgery. American volume — Wed, 02 Nov 2011 04:00:00 +0100

Conclusions:Local cryotherapy and compression after knee arthroscopy significantly lowered the temperature in the knee postoperatively, and the synovial PGE2 concentration was correlated with the temperature. Since PGE2 is a marker of pain and inflammation, the postoperative local cooling and compression appeared to have a positive anti-inflammatory effect.Level of Evidence:Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence. PMID: 22048090 [PubMed - in process] (Source: The Journal of Bone and Joint Surgery. American volume)

Keratoacanthoma, Trauma, and Cryotherapy

Dermatologic Surgery — Tue, 01 Nov 2011 04:00:00 +0100

(Source: Dermatologic Surgery)

Ocular Surface Squamous Neoplasia in an Anophthalmic Socket 60 Years after Enucleation

Survey of Ophthalmology — Tue, 01 Nov 2011 04:00:00 +0100

We report a 62-year-old white man who had his left eye enucleated at age 2 and developed an invasive squamous cell carcinoma 60 years later. He received multiple treatments, including excisional biopsy, topical mitomycin C chemotherapy, cryotherapy, and finally exenteration. We review the literature to evaluate the clinical characteristics, time of onset following enucleation, treatment, and outcome of previously reported cases. Our case emphasizes the importance of a thorough examination of the anophthalmic socket, including upper and lower lid eversion. (Source: Survey of Ophthalmology)

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Focal cryotherapy for localized prostate cancer: a report from the national Cryo On‐Line Database (COLD) Registry

BJU International — Fri, 28 Oct 2011 04:00:00 +0100

CONCLUSIONS• Focal cryoablation is increasingly used for selected patients with prostate cancer.• Oncological efficacy in the present series appears similar to that of whole‐gland cryoablation.• The impact of focal cryoablation on urinary, sexual and bowel function appears to be less than that of radical therapies, although preservation of sexual function is not as high as might be expected. (Source: BJU International)

A Refractory Wart?

Annals of Emergency Medicine — Sat, 22 Oct 2011 06:38:26 +0100

A 12-year-old healthy boy was evaluated for a growth under his right great toenail (). The lesion was initially diagnosed as a subungual verruca and treated for 4 months with topical salicylic acid and cryotherapy. No improvement was observed, and the growth continued to enlarge and became increasingly painful. Radiographs of the right foot demonstrated an osseous protuberance at the distal phalanx (). (Source: Annals of Emergency Medicine)

Feasibility of spray cryotherapy and balloon dilation for non-malignant strictures of the airway [Original articles]

European Journal of Cardio-Thoracic Surgery — Thu, 20 Oct 2011 04:00:00 +0100

Conclusions: Initial experience with SC for benign airway strictures suggests that this can be used safely. This is effective in improving symptoms and reducing the severity of airway narrowing. Re-intervention is still required. Further study should be undertaken to determine factors that may be associated with success or failure as well as the relative efficacy of SC compared with other endoscopic therapies. (Source: European Journal of Cardio-Thoracic Surgery)

Summary of the British Thoracic Society Guidelines for advanced diagnostic and therapeutic flexible bronchoscopy in adults

Thorax — Fri, 14 Oct 2011 04:00:00 +0100

This new guideline covers the rapidly advancing field of interventional bronchoscopy using flexible bronchoscopy. It includes the use of more complex diagnostic procedures such as endobronchial ultrasound, interventions for the relief of central airway obstruction due to malignancy and the recent development of endobronchial therapies for chronic obstructive pulmonary disease and asthma. The guideline aims to help all those who undertake flexible bronchoscopy to understand more about this important area. It also aims to inform respiratory physicians and other specialists dealing with lung cancer of the procedures possible in the management and palliation of central airway obstruction. The guideline covers transbronchial needle aspiration and endobronchial ultrasound-guided transbronchial n...

Achieving the ‘bifecta’ using salvage cryotherapy for locally recurrent prostate cancer: analysis of the Cryo On‐Line Data (COLD) Registry data

BJU International — Wed, 12 Oct 2011 04:00:00 +0100

CONCLUSIONS• The therapeutic ‘bifecta’, a new surrogate benchmark for salvage therapies, can be achieved in most patients undergoing salvage cryotherapy.• Therefore, salvage cryotherapy is a reasonable treatment choice for locally recurrent prostate cancer in appropriately selected patients. (Source: BJU International)

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In vivo vitiligo induction and therapy model : double blind, randomized clinical trial

Pigment Cell Research — Mon, 10 Oct 2011 04:00:00 +0100

In this study, we developed an in vivo vitiligo induction model to explore the underlying mechanisms leading to Koebner’s phenomenon and to evaluate the efficacy of therapeutic strategies. The model consisted of 12 pigmented test regions on the back of generalized vitiligo patients that were exposed to 3 Koebner induction methods: cryotherapy, 755nm laser therapy and epidermal abrasion. In addition, 4 cream treatments (pimecrolimus, tacrolimus, steroid and placebo) were randomly applied. Koebnerization was efficiently induced by all 3 induction methods. In general, cryotherapy was the best method of koebner induction, followed by 755nm laser therapy and epidermal abrasion. Reproducible results were obtained which showed enhanced depigmented surface areas and higher amounts of T lymphocyt...

In vivo vitiligo induction and therapy model: double‐blind, randomized clinical trial

Pigment Cell Research — Mon, 10 Oct 2011 04:00:00 +0100

In this study, we developed an in vivo vitiligo induction model to explore the underlying mechanisms leading to Koebner’s phenomenon and to evaluate the efficacy of therapeutic strategies. The model consisted of 12 pigmented test regions on the back of generalized vitiligo patients that were exposed to three Koebner induction methods: cryotherapy, 755 nm laser therapy, and epidermal abrasion. In addition, four cream treatments (pimecrolimus, tacrolimus, steroid and placebo) were randomly applied. Koebnerization was efficiently induced by all three induction methods. In general, cryotherapy was the best method of Koebner induction, followed by 755 nm laser therapy and epidermal abrasion. Reproducible results were obtained, which showed enhanced depigmented surface areas and higher amo...

In vivo vitiligo induction and therapy model: double-blind, randomized clinical trial.

Pigment Cell and Melanoma Research — Mon, 10 Oct 2011 04:00:00 +0100

In this study, we developed an in vivo vitiligo induction model to explore the underlying mechanisms leading to Koebner's phenomenon and to evaluate the efficacy of therapeutic strategies. The model consisted of 12 pigmented test regions on the back of generalized vitiligo patients that were exposed to three Koebner induction methods: cryotherapy, 755 nm laser therapy, and epidermal abrasion. In addition, four cream treatments (pimecrolimus, tacrolimus, steroid and placebo) were randomly applied. Koebnerization was efficiently induced by all three induction methods. In general, cryotherapy was the best method of Koebner induction, followed by 755 nm laser therapy and epidermal abrasion. Reproducible results were obtained, which showed enhanced depigmented surface areas and higher amoun...

Treatment of mucositis in patients undergoing bone marrow transplantation: a systematic review

Acta Paulista de Enfermagem — Mon, 03 Oct 2011 14:04:27 +0100

CONCLUSION: The heterogeneity of the results of these interventions and the lack of better elucidation for healthcare practice indicate the need for more accurate research to identify the effectiveness of topical therapies for repair of mucosal cells.OBJETIVO: Identificar las medidas terapéuticas para la reducción de la gravedad de la mucositis oral en pacientes adultos sometidos a Transplante de Médula Ósea (TMO). MÉTODOS: Se trata de una revisión sistemática en las bases de datos: LILACS, MEDLINE, CINAHL, EMBASE; CENTRAL (Cochrane Central) y DARE (Database of abstracts of reviews of effects), en el período de 1972 a julio del 2010, utilizando los descriptores mucositis, stomatitis y bone-marrow-transplantation. RESULTADOS: Se identificaron 3.839 resúmenes, y de éstos 22 fueron ...

Understanding Retinopathy of Prematurity: Update on Pathogenesis.

Neonatology — Mon, 03 Oct 2011 04:00:00 +0100

Authors: Rivera JC, Sapieha P, Joyal JS, Duhamel F, Shao Z, Sitaras N, Picard E, Zhou E, Lachapelle P, Chemtob S Abstract Retinopathy of prematurity (ROP), an ocular disease characterized by the onset of vascular abnormalities in the developing retina, is the major cause of visual impairment and blindness in premature neonates. ROP is a complex condition in which various factors participate at different stages of the disease leading to microvascular degeneration followed by neovascularization, which in turn predisposes to retinal detachment. Current ablative therapies (cryotherapy and laser photocoagulation) used in the clinic for the treatment of ROP have limitations and patients can still have long-term effects even after successful treatment. New treatment modalities are still e...

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The role of cryotherapy in the management of aggressive odontogenic lesions

International Journal of Oral and Maxillofacial Surgery — Sat, 01 Oct 2011 04:00:00 +0100

Liquid nitrogen cryosurgery, boiling at −196°C, has been shown to be an effective physicochemical treatment to decrease the recurrence rate of aggressive odontogenic lesions. Following enucleation and curettage of the lesion, the application of liquid nitrogen, generally by means of a spray but sometimes utilizing a probe, will devitalize bone to a depth of 1–2mm beyond the visible edge of the bone. This devitalized bone retains it inorganic structure and forms a framework for new bone formation. If nerves are affected by the liquid nitrogen, they will generally recover and overall recurrence rates are decreased to 5–10%. (Source: International Journal of Oral and Maxillofacial Surgery)

Demographic, clinical, radiographic, histopathological and therapeutic features of ameloblastoma

International Journal of Oral and Maxillofacial Surgery — Sat, 01 Oct 2011 04:00:00 +0100

This study aimed to retrospectively analyze and correlate the demographic, clinical, radiographic, histopathological and therapeutic features of those tumors. Forty-one medical records from an Oral and Maxillofacial Surgery service were analyzed and their histopathological diagnoses were reviewed. Data were analyzed using appropriate statistical tests. The sample comprised 14 men and 27 women with a mean age of 38.9 years. The posterior area of the mandible was the most affected anatomic area, with 36 cases and the multilocular radiographic was the most common subtype (79.4%), followed by the unilocular subtype (20.6%). Complains of pain were reported in only 12 patients. The histopathological findings were: 39% follicular, 34.1% plexiform, and 14.6% unicystic. The treatment with marginal ...

Advances in Laminitis research at the Australian Equine Laminitis Research Unit

Journal of Equine Veterinary Science — Sat, 01 Oct 2011 04:00:00 +0100

1) Hyperinsulinemia, likely acting through lamellar insulin-like growth factor receptors, triggers inappropriate lamellar proliferation, lamellar weakening, and thus laminitis. Every effort should be made to identify and correct hyperinsulinemia. 2) Lamellar bioenergetics are currently being investigated in the pathophysiology of supporting limb laminitis. 3) The lamellar disintegration of carbohydrate overload-induced laminitis occurs well before clinical signs appear, as early as 12 h after dosing. Targeted inhibition of the proteases which contribute to lamellar compromise is currently being studied. 4) Chronic laminitis involves dysplastic horn growth which may contribute to chronic pain, distal phalanx rotation and lysis, and permanent structural changes to the hoof. Early hoof wall r...

Efficacy of cryotherapy in blocking laminar inflammatory events in oligofructose-induced laminitis

Journal of Equine Veterinary Science — Sat, 01 Oct 2011 04:00:00 +0100

Local hypothermia (cryotherapy), applied to the distal limb throughout the developmental/prodromal period of laminitis, markedly inhibits multiple inflammatory signaling mechanisms. (Source: Journal of Equine Veterinary Science)

Cryosurgery and rhTNF-α play synergistic effects on a rat cortex C6 glioma model.

Cryobiology — Thu, 29 Sep 2011 04:00:00 +0100

Authors: Huang KM, Peng M, Feng YQ, Huang H, Tu HJ, Luo J, Zhang L, Yuan XH, Wang LC Abstract Glioma, a type of brain tumor originating from glioma cells, varies widely in aggressiveness and causes serious symptoms, but the treatments are limited. Studies have shown that cryosurgery has multiple effects on tumor treatments, and administration of human tumor necrosis factor-alpha (rhTNF-α) arguments the anti-tumor effect of cryotherapy in breast and prostate cancers. To test the hypothesis that cryosurgery and rhTNF-α play synergistic effects against brain tumors, we established a brain glioma model on rat cortex regions following different treatments: the G1 group was sham-operated; the G2 group was treated with cryosurgery; the G3 group was treated with rhTNF-α; and G4 group re...

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Cryotherapy No Better Than 50% Salicylic Acid, Costs MoreCryotherapy No Better Than 50% Salicylic Acid, Costs More

Medscape Today Headlines — Tue, 27 Sep 2011 19:29:10 +0100

For cutaneous warts, salicylic acid is similar in efficacy compared with cryotherapy, although cryotherapy costs more. Medscape Medical News (Source: Medscape Today Headlines)

93 Salvage robot assisted radical prostatectomy after radiation failure and focal cryotherapy

European Urology Supplements — Mon, 26 Sep 2011 17:49:46 +0100

(Source: European Urology Supplements)

Nigeria: Oshiomhole Moves Against Cancer

AllAfrica News: Health and Medicine — Mon, 26 Sep 2011 15:13:35 +0100

In a bid to make the treatment of cancer accessible and affordable to the people, the Edo State Government has procured 69 new cryotherapy machines for state hospitals for early treatment of patients. (Source: AllAfrica News: Health and Medicine)

Cryotherapy Or Salicylic Acid Treatment Of Verrucae Equally As Effective

Health News from Medical News Today — Thu, 22 Sep 2011 10:00:00 +0100

In a project funded by the National Institute for Health Research Health Technology Assessment (NIHR HTA), researchers discovered that there is no evidence of a difference in clearance rates between patient self-treatment for verrucae (A type of wart) and treatment received by healthcare professionals. Verrucae are common, infectious and sometimes painful, and although most verrucae spontaneously disappear without treatment, many patients seek out health professionals to remove the wart because they experience pain or it prevents them from sporting activities... (Source: Health News from Medical News Today)

NHS HTA: Cryotherapy versus salicylic acid for the treatment of verrucae - EVerT: a randomised controlled trial

NeLM - News — Wed, 21 Sep 2011 04:00:00 +0100

Source: NHS HTA Area: News The NHS Health Technology Assessment programme has featured a trial assessing the clinical effectiveness and cost-effectiveness of cryotherapy using liquid nitrogen, versus patient daily self-treatment with 50% salicylic acid for the treatment of verrucae (plantar warts). The multicentre, open -label, two-armed randomised controlled trial involved 240 patients (aged over 12 years) with a verruca which, in the opinion of the health-care professional, was suitable for treatment with both salicylic acid and cryotherapy. Patients were randomised to receive cryotherapy using liquid nitrogen delivered by a health-care professional (n=117) or daily patient self-treatment with 50% salicylic acid (n=123) for a maximum of 8 weeks. The primary outcome...

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Hepatic Gas: Widening Spectrum of Causes Detected at CT and US in the Interventional Era [Gastrointestinal Imaging]

Radiographics recent issues — Wed, 14 Sep 2011 04:00:00 +0100

The spectrum of causes of hepatic gas detected at computed tomography (CT) and ultrasonography (US) is widening. There are many iatrogenic and noniatrogenic causes of hepatic parenchymal, biliary, hepatic venous, and portal venous gas. Hepatic gas may be an indicator of serious acute disease (infarct, infection, abscess, bowel inflammation, or trauma). In other clinical scenarios, it may be an expected finding related to therapeutic interventions (such as surgery; hepatic artery embolization for a tumor or for active bleeding in acute trauma cases; percutaneous tumor ablation performed with radiofrequency, cryotherapy, laser photocoagulation, or ethanol). In some cases, hepatic gas is an incidental finding of no clinical significance. Familiarity with the expanding list of newer interventi...

Two Decades of Experience with Hepatic Cryotherapy for Advanced Colorectal Metastases

Annals of Surgical Oncology — Tue, 13 Sep 2011 05:49:42 +0100

Conclusions Hepatic cryotherapy seems to be a safe and effective ablative technique for the treatment of colorectal liver metastases and may offer long-term survival in otherwise unresectable disease. Content Type Journal ArticleCategory Hepatobiliary TumorsPages 1-8DOI 10.1245/s10434-011-2025-4Authors Keh M. Ng, Hepatobiliary and Surgical Oncology Unit, Department of Surgery, St George Hospital, University of New South Wales, Sydney, NSW, AustraliaTerence C. Chua, Hepatobiliary and Surgical Oncology Unit, Department of Surgery, St George Hospital, University of New South Wales, Sydney, NSW, AustraliaAkshat Saxena, Hepatobiliary and Surgical Oncology Unit, Department of Surgery, St George Hospital, University of New South Wales, Sydney, NSW, AustraliaJing Zhao, Hepat...

Evaluation of the effect of cryotherapy in preventing oral mucositis associated with chemotherapy - A randomized controlled trial.

European Journal of Oncology Nursing — Sat, 10 Sep 2011 04:00:00 +0100

CONCLUSIONS: We found that oral cryotherapy has a significant contribution to the protection of oral health by reducing mucositis score according to the WHO mucositis scale, especially on the 7th and 14th days. Nurses' awareness of how cryotherapy can affect patients and options for resolving problems will enable them to provide a higher standard of individualized care. PMID: 21911313 [PubMed - as supplied by publisher] (Source: European Journal of Oncology Nursing)

Retinoblastoma in Central America: Report from the Central American Association of Pediatric Hematology Oncology (AHOPCA)

Pediatric Blood and Cancer — Fri, 09 Sep 2011 04:00:00 +0100

ConclusionsProtocol‐directed therapy for retinoblastoma in Central America is possible. Patients present with advanced disease and outcome is significantly worse than in middle and high‐income countries. Refusal and abandonment of therapy are societal events that affect outcome. Initiatives aimed at improving early diagnosis, while dedicated treatment centers are developed, are critical. Pediatr Blood Cancer © 2011 Wiley‐Liss, Inc. (Source: Pediatric Blood and Cancer)

Well Blog: More Athletes Using Cryotherapy to Speed Recovery

NYT Health — Wed, 07 Sep 2011 04:01:13 +0100

Whole-body cryotherapy is, essentially, ice baths taken to a new and otherworldly level, and it is drawing considerable attention among athletes, both elite and recreational. (Source: NYT Health)

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Well: More Athletes Using Cryotherapy to Speed Recovery

NYT Health — Wed, 07 Sep 2011 04:01:13 +0100

Whole-body cryotherapy is, essentially, ice baths taken to a new and otherworldly level, and it is drawing considerable attention among athletes, both elite and recreational. (Source: NYT Health)

Correction of susceptibility-induced GRE phase shift for accurate PRFS thermometry proximal to cryoablation iceball

Magnetic Resonance Materials in Physics, Biology and Medicine — Tue, 06 Sep 2011 15:51:24 +0100

Conclusion By implementing on-line the post processing algorithm, PRFS MRT may be used as a safety tool for non-invasive and accurate monitoring of near-zero temperatures during MR-guided clinical cryotherapy. Content Type Journal ArticleCategory Research ArticlePages 1-9DOI 10.1007/s10334-011-0277-4Authors Antje Kickhefel, Eberhard-Karls-University Tübingen, Tübingen, Badem-Württenberg, GermanyClifford Weiss, Johns Hopkins University, Baltimore, USAJoerg Roland, Siemens Healthcare, Erlangen, GermanyPatrick Gross, Siemens Healthcare, Erlangen, GermanyFritz Schick, Eberhard-Karls-University Tübingen, Tübingen, Badem-Württenberg, GermanyRares Salomir, University Hospitals of Geneva, Geneva, Switzerland Journal Magnetic Resonance Materials in Physics, Biolo...

Temperature changes in rheumatoid hand treated with nitrogen vapors and cold air

Rheumatology International — Tue, 06 Sep 2011 15:50:08 +0100

Abstract The aim of the study was the thermovisual comparison of mean temperature of hand surface changes after local cryotherapy with vapors of nitrogen (−160°C) and cold air (−30°C). Forty-seven patients with rheumatoid arthritis (39 women and 8 men; average age 56.2 ± 10.5 years) were included in the study. They had the application of topic cryotherapy using nitrogen vapors or cold air on one hand. Main outcome measure was surface temperature of dorsal sides of the cooled and contralateral hands. Thermal images of both hands were taken before and up to 3 h after the treatment. One minute after application, nitrogen vapors induced decrease in surface skin temperature of the cooled hand from 28.9 ± 1.8°C to 17.9 ± 2.2°C, P...

Correction of susceptibility-induced GRE phase shift for accurate PRFS thermometry proximal to cryoablation iceball.

Magma — Sun, 04 Sep 2011 04:00:00 +0100

CONCLUSION: By implementing on-line the post processing algorithm, PRFS MRT may be used as a safety tool for non-invasive and accurate monitoring of near-zero temperatures during MR-guided clinical cryotherapy. PMID: 21898135 [PubMed - as supplied by publisher] (Source: Magma)

Is there a contemporary role for percutaneous needle biopsy in the era of small renal masses?

BJU International — Thu, 01 Sep 2011 23:00:00 +0100

CONCLUSION There is a contemporary role for RMB in the era of SRM as the incorporation of molecular profiling of tissue from RMB would augment our ability to risk stratify SRMs on an individual patient basis and adopt management accordingly. However, clinical judgement is paramount as there remains an unpredictable non‐negligible risk of disease progression and metastasis whilst on surveillance. (Source: BJU International)

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Cochrane Review: Topical treatments for cutaneous warts

Evidence-Based Child Health: A Cochrane Review Journal — Thu, 01 Sep 2011 04:00:00 +0100

Patterns of Recurrence After Ablation of Colorectal Cancer Liver Metastases

Annals of Surgical Oncology — Wed, 31 Aug 2011 05:51:32 +0100

Conclusions Intraoperative ablation appears to be highly effective treatment for hepatic colorectal tumors ≤1 cm. Content Type Journal ArticleCategory Hepatobiliary TumorsPages 1-8DOI 10.1245/s10434-011-2048-xAuthors T. Peter Kingham, Division of Hepatopancreatobiliary Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USAMichael Tanoue, Creighton University School of Medicine, Omaha, NE, USAAnne Eaton, Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USAFlavio G. Rocha, Division of Hepatopancreatobiliary Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USARichard Do, Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, USAPeter Allen, Division of Hepatopancreat...

Reemergence of dormant Coats disease after 30 years.

European Journal of Ophthalmology — Tue, 30 Aug 2011 04:00:00 +0100

Conclusions. Coats disease must be considered as a chronic disease, which necessitates a very long-term follow-up even in the absence of subjective visual loss. The disease can reawaken and recur with force in previously unaffected areas of the retina several decades later. The gold standard treatment consists of cryotherapy and argon laser. However, in cases of very important retinal exudation, surgical management with subretinal drainage may be necessary. PMID: 21928259 [PubMed - as supplied by publisher] (Source: European Journal of Ophthalmology)

Pulmonary vein isolation with radiofrequency ablation followed by cryotherapy: a novel strategy to improve clinical outcomes following catheter ablation of paroxysmal atrial fibrillation

Europace — Mon, 22 Aug 2011 23:00:00 +0100

Conclusion The combined approach was safe and increased single procedure efficacy of PV isolation for AF compared with either technique alone. (Source: Europace)

Ablative therapies for colorectal liver metastases: a systematic review

Colorectal Disease — Sat, 20 Aug 2011 16:39:57 +0100

Conclusion Ablative therapies offer significantly improved survival compared with palliative chemotherapy alone with 5‐year survival rates of 17–24%. Complication rates amongst commonly used techniques are low. (Source: Colorectal Disease)

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Prospective trial of curettage and cryosurgery in the management of non‐facial, superficial, and minimally invasive basal and squamous cell carcinoma

International Journal of Dermatology — Sat, 20 Aug 2011 15:40:38 +0100

Conclusions Curettage and cryosurgery is a simple, highly effective, and reliable treatment method for select, low‐risk non‐melanoma skin cancers. (Source: International Journal of Dermatology)

Treatment options for localized prostate cancer.

American Family Physician — Sun, 14 Aug 2011 23:00:00 +0100

Authors: Mohan R, Schellhammer PF Abstract In the United States, more than 90 percent of prostate cancers are detected by serum prostate-specific antigen testing. Most patients are found to have localized prostate cancer, and most of these patients undergo surgery or radiotherapy. However, many patients have low-risk cancer and can follow an active surveillance protocol instead of undergoing invasive treatments. Active surveillance is a new concept in which low-risk patients are closely followed and proceed to intervention only if their cancer progresses. Clinical guidelines can help in selecting between treatment or active surveillance based on the cancer's stage and grade, the patient's prostate-specific antigen level, and the comorbidity-adjusted life expectancy. Radical prostat...

Aspirin is not a risk factor of haemorrhagic complications during or after surgery of primary rhegmatogenous retinal detachment

Acta Ophthalmologica — Sat, 13 Aug 2011 09:30:06 +0100

Conclusion Aspirin was not an independent risk factor of hemorrhagic complications during and after surgery of primary rhegmatogenous RD. The bleeding risk is instead associated with surgical factors such as PPV, cryotherapy, and subretinal fluid drainage. (Source: Acta Ophthalmologica)

Prognostic factors for anatomical and functional results after retinal detachment surgery. The SPR study

Acta Ophthalmologica — Sat, 13 Aug 2011 09:19:14 +0100

Conclusion The most important risk factor for functional and anatomical failure was a higher number of retinal breaks. Other risk factors varied between the phakic and pseudophakic patients as well as between functional and anatomical outcomes. These findings are of clinical importance for identification of patients with a higher risk for failure and for the planning of future trials on RD surgery. (Source: Acta Ophthalmologica)

Effect of walking and resting after three cryotherapy modalities on the recovery of sensory and motor nerve conduction velocity in healthy subjects

Revista Brasileira de Fisioterapia — Thu, 11 Aug 2011 17:13:34 +0100

BACKGROUND: Different cryotherapy modalities have distinct effects on sensory and motor nerve conduction parameters. However, it is unclear how these parameters change during the post-cooling period and how the exercise carried out in this period would influence the recovery of nerve conduction velocity (NCV). OBJECTIVES: To compare the effects of three cryotherapy modalities on post-cooling NCV and to analyze the effect of walking on the recovery of sensory and motor NCV. METHODS: Thirty six healthy young subjects were randomly allocated into three groups: ice massage (n=12), ice pack (n=12) and cold water immersion (n=12). The modalities were applied to the right leg. The subjects of each modality group were again randomized to perform a post-cooling activity: a) 30min rest, b) walking 1...

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Galil Medical Announces Reimbursement for Small Renal Cancer Cryoablation in Japan

HSMN NewsFeed — Tue, 09 Aug 2011 14:28:06 +0100

Cryotherapy Continues to Grow as the Treatment of Choice for Renal Tumors Around the World ARDEN HILLS, Minnesota, August 9, 2011 (HSMN NewsFeed) -- Galil Medical, a global leader in minimally invasive cryotherapy treatments, announced today that Japa... Devices, Oncology, ReimbursementGalil Medical, cryoablation, CryoHit/SeedNet (Source: HSMN NewsFeed)

Recurrent disease following endoscopic ablation of Barrett’s high-grade dysplasia with spray cryotherapy

Endoscopy — Sun, 07 Aug 2011 23:00:00 +0100

EndoscopyDOI: 10.1055/s-0030-1256649Background and aims: Recurrent disease after endoscopic ablation of Barrett’s esophagus should be detected early to prevent malignant progression. We assessed the incidence and patterns of disease recurrence in patients after liquid nitrogen spray cryotherapy ablation of Barrett‘s esophagus with high grade dysplasia (HGD), including the area below the neosquamocolumnar junction (NSCJ).[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Abstract | Full text (Source: Endoscopy)

[Recto-vesico-cutaneous fistula following salvage cryotherapy of the prostate due to recurrent localized prostate cancer.]

Der Urologe. Ausg. A — Wed, 03 Aug 2011 23:00:00 +0100

We report a serious complication of salvage cryotherapy in a 72-year-old man suffering from a severe recto-vesico-cutaneous fistula 6 weeks after salvage cryotherapy. To manage this situation salvage cystoprostatectomy and continent urinary diversion with creation of an ileocaecal pouch with cutaneous stoma had to be performed. PMID: 21811839 [PubMed - as supplied by publisher] (Source: Der Urologe. Ausg. A)

Oral Mucosal Graft With Amniotic Membrane Transplantation for Total Limbal Stem Cell Deficiency

American Journal of Ophthalmology — Mon, 01 Aug 2011 04:00:00 +0100

Conclusions: Oral mucosal graft is a viable alternative for treating total limbal stem cell deficiency in eyes where transplantation of allogeneic limbal stem cells has failed or is not feasible. (Source: American Journal of Ophthalmology)

Cryotherapy and Topical Minocycline as Adjunctive Measures to Control Pain After Third Molar Surgery: An Exploratory Study

Journal of Oral and Maxillofacial Surgery — Mon, 01 Aug 2011 04:00:00 +0100

Conclusions: Data from this exploratory study suggest that adjunctive therapy to decrease postoperative pain—cryotherapy or topical minocycline—might be effective at moderating the patient's highest pain levels after third molar surgery. The topic should be studied further in a multicenter, prospective, randomized trial. (Source: Journal of Oral and Maxillofacial Surgery)

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Intravitreal Methotrexate for Retinoblastoma

Ophthalmology — Sun, 31 Jul 2011 23:00:00 +0100

Chemoreduction with vincristine, etoposide, and carboplatin followed by transpupillary thermotherapy, cryotherapy, and brachytherapy cures 95%−100% of group A−C and 50%−60% of group D and E eyes and minimizes the need for external beam radiotherapy and enucleation in managing retinoblastoma (Rb). However, 40%−50% of group D−E eyes develop unresponsive relapses, which often are diffuse vitreous and subretinal seeds. They are the major reason for later external beam radiotherapy and enucleation. (Source: Ophthalmology)

Treatment of nongenital cutaneous warts.

American Family Physician — Sun, 31 Jul 2011 23:00:00 +0100

Authors: Mulhem E, Pinelis S Abstract Numerous treatments for nongenital cutaneous warts are available, although no single therapy has been established as completely curative. Watchful waiting is an option for new warts because many resolve spontaneously. However, patients often request treatment because of social stigma or discomfort. Ideally, treatment should be simple and inexpensive with low risk of adverse effects. Salicylic acid has the best evidence to support its effectiveness, but it is slow to work and requires frequent application for up to 12 weeks. Cryotherapy with liquid nitrogen is a favorable option for many patients, with cure rates of 50 to 70 percent after three or four treatments. For recalcitrant warts, Candida or mumps skin antigen can be injected into the war...

Cantharidin–podophylotoxin–salicylic acid versus cryotherapy in the treatment of plantar warts: a randomized prospective study

Journal of the European Academy of Dermatology and Venereology — Mon, 25 Jul 2011 23:00:00 +0100

Conclusion Topical CPS is more effective than cryotherapy in the treatment of plantar warts. (Source: Journal of the European Academy of Dermatology and Venereology)

Oral cryotherapy can significantly reduce oral mucositis but not acute GVHD incidence in Flu/Mel conditioning allo-SCT

Bone Marrow Transplantation — Sun, 24 Jul 2011 23:00:00 +0100

Oral cryotherapy can significantly reduce oral mucositis but not acute GVHD incidence in Flu/Mel conditioning allo-SCT Bone Marrow Transplantation advance online publication, July 25, 2011. doi:10.1038/bmt.2011.156 Authors: S Vokurka, T Svoboda, A Jungova, M Karas & V Koza (Source: Bone Marrow Transplantation)

Re: Salvage Radical Prostatectomy Following Primary High Intensity Focused Ultrasound for Treatment of Prostate Cancer: N. Lawrentschuk, A. Finelli, T. H. van der Kwast, P. Ryan, D. M. Bolton, N. E. Fleshner, J. Trachtenberg, L. Klotz, M. Robinette and H. Woo J Urol 2011;185: 862–868

The Journal of Urology — Sun, 24 Jul 2011 23:00:00 +0100

We wish to thank Lawrentschuk et al for sharing the outcomes of their series of patients undergoing salvage radical prostatectomy following primary whole gland high intensity focused ultrasound (HIFU) treatment. This cohort represents a management challenge, so we congratulate the authors for a valuable contribution to an area that lacks robust data. These prospective results correlate with salvage radiotherapy following primary HIFU, with oncologic and functional outcomes that are acceptable for such a high risk group. In addition, outcomes from this series are similar to other salvage prostatectomy studies, including a series of 15 patients undergoing salvage laparoscopic radical prostatectomy following primary external beam radiotherapy, brachytherapy or cryotherapy. (Source: The Journa...

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Treatment of Squamous Cell Carcinoma In Situ: A Review

Dermatologic Surgery — Sun, 17 Jul 2011 23:00:00 +0100

CONCLUSION There are many methods available to treat SCCIS. Physicians should consider each patient's situation while keeping in mind that treatment protocols have not been fully defined for most options.The authors have indicated no significant interest with commercial supporters. (Source: Dermatologic Surgery)

A pilot study of clinical efficacy of imiquimod and cryotherapy for the treatment of basal cell carcinoma with incomplete response to imiquimod

Journal of the European Academy of Dermatology and Venereology — Sat, 16 Jul 2011 16:20:22 +0100

Conclusions Cryotherapy applied to treat imiquimod‐refractory basal cell carcinoma seems to sensitize the tumour to the effect of the drug, thus reducing the percentage of patients who need surgery after an incomplete response to imiquimod. Further studies are necessary to confirm these findings. (Source: Journal of the European Academy of Dermatology and Venereology)

Safety, feasibility, and acceptability of visual inspection with acetic acid and immediate treatment with cryotherapy in rural Laos

International Journal of Gynaecology and Obstetrics — Thu, 14 Jul 2011 23:00:00 +0100

Conclusion: Visual inspection with acetic acid is a simple test that requires minimal infrastructure and expenditure. Integration of VIA with cryotherapy at the primary care level may constitute a feasible program for the prevention of cervical cancer in Laos. (Source: International Journal of Gynaecology and Obstetrics)

CSA Medical Completes $12.6 Million Series A Financing With Additional Venture Investment From Blue Heron Capital

HSMN NewsFeed — Tue, 12 Jul 2011 20:16:15 +0100

BALTIMORE, July 12, 2011 (HSMN NewsFeed) -- CSA Medical, Inc., the leading developer of novel Spray Cryotherapy devices that flash freeze and treat diseased tissue inside the body, today announced that it has completed an oversubscribed $12.6 million Ser... Devices, Venture CapitalCSA Medical, Spray Cryotherapy (Source: HSMN NewsFeed)

Try duct tape for warts

BMJ Online First — Mon, 11 Jul 2011 23:00:00 +0100

Only one randomised study has investigated duct tape for treating warts,1 but duct tape seems to be better than cryotherapy.2 It has no adverse effects and is cheap and readily available without... (Source: BMJ Online First)

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Study did not use standard cryotherapy for warts

BMJ Online First — Mon, 11 Jul 2011 23:00:00 +0100

Cockayne and colleagues compared a “gentle freeze” with liquid nitrogen using a spray or probe with salicyclic acid for treating plantar warts.1 This haphazard application of liquid nitrogen cannot... (Source: BMJ Online First)

Study ignored patient views in wart recommendations

BMJ Online First — Mon, 11 Jul 2011 23:00:00 +0100

I am surprised that Cockayne and colleagues overlooked patient satisfaction in the discussion and conclusion of their randomised controlled trial of cryotherapy and salicylic acid for plantar warts.1... (Source: BMJ Online First)

Subfoveal Choroidal Melanoma: Pretreatment Characteristics and Response to Plaque Radiation Therapy [Clinical Sciences]

Archives of Opthalmology — Sun, 10 Jul 2011 23:00:00 +0100

Conclusions Subfoveal choroidal melanomas in this series are almost exclusively dome shaped and likely to have an associated exudative retinal detachment. They are amenable to plaque radiation therapy. However, this tumor location is associated with a high incidence of radiation maculopathy and a low incidence of radiation cataract. (Source: Archives of Opthalmology)

A randomized clinical comparative study of cryotherapy plus photodynamic therapy vs. cryotherapy in the treatment of multiple condylomata acuminata

Photodermatology, Photoimmunology and Photomedicine — Thu, 07 Jul 2011 17:07:30 +0100

Conclusion: Cryotherapy plus ALA‐PDT is a more effective regimen for the treatment of multiple CA compared with cryotherapy alone. (Source: Photodermatology, Photoimmunology and Photomedicine)

How Effective Is Intralesional Candida Antigen for Treatment of Warts?

PediatricEducation.org — Mon, 04 Jul 2011 00:55:24 +0100

This study had a large dropout rate though (for warts 67% and for molluscum 47%). In another small study of 18 patients, 11 completed the study and 9 (82%) had complete resolution and 1 (9%)had partial resolution, with a median of 4 every 3-week injections. Also, 6 of 9 patients (67%) with additional warts at distant locations had resolution of those warts. Questions for Further Discussion 1. What is the cost of intralesional treatment with Candida antigen? 2. How effective is mumps or trichophytin antigen intralesional treatment of plantar warts? 3. How is intralesional candida antigen given? 4. How are plantar warts spread? Related Cases Disease: Warts | Human Papillomavirus Symptom/Presentation: Papulosquamous Lesions Specialty: Dermatology | Immunology | Infectious Diseases | Pharma...

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Cryopeeling for treatment of photodamage and actinic keratosis: liquid nitrogen versus portable system

Anais Brasileiros de Dermatologia — Sun, 03 Jul 2011 18:03:30 +0100

FUNDAMENTOS: O criopeeling utiliza a crioterapia difusa não somente nas lesões de ceratose actínica, mas em toda a pele fotodanificada. OBJETIVOS: Comparar dois métodos de criopeeling (nitrogênio líquido e sistema portátil de éter dimetílico, propano e isobutano) quanto à eficiência no tratamento de ceratoses actínicas, tolerabilidade do paciente, preferência do paciente e do pesquisador e resultado estético. MÉTODOS: Dezesseis pacientes (n=16) com múltiplas ceratoses actínicas nos antebraços foram submetidos ao criopeeling com nitrogênio líquido em um dos antebraços e com o sistema portátil no outro, randomicamente. RESULTADOS: No tratamento das ceratoses actínicas, o nitrogênio líquido obteve 74% de eficiência e o sistema portátil, 62% (p=0,019). A média da es...

Eugene Chiropractors Offer Spinal Decompression And Other Advanced Therapies

Health News from Medical News Today — Fri, 01 Jul 2011 11:00:00 +0100

Chiropractors have long treated neck and back pain, but Absolute Wellness Center has now included in its practice many forms of advanced therapies not generally found in a chiropractor's office. Advanced therapies such as cryotherapy, interferential stimulation and microcurrent therapies allow these Eugene chiropractors to tend to a wider variety of ailments and patients. Such therapies are non-surgical methods to alleviate pain, promote healing and treat a variety of injuries, whether the pain and suffering is due to an auto injury, a fall or simply a wrenching twist or movement... (Source: Health News from Medical News Today)

Chronic postherniorrhaphy pain following inguinal hernia surgery: Etiology, risk factors, anatomy, and treatment options

Techniques in Regional Anesthesia and Pain Management — Fri, 01 Jul 2011 04:00:00 +0100

Despite recent advances in surgical technique for inguinal hernia repair, chronic groin pain following the surgical repair of an inguinal hernia is not uncommon. Injury to the ilioinguinal, iliohypogastric, or genitofemoral nerves is the most common etiology. Specific risk factors that increase the likelihood of developing chronic groin pain have been identified. Ultrasound-guided peripheral nerve blocks may play an important role in the diagnosis and treatment of chronic groin pain. As in many pain syndromes, early diagnosis and early treatment are crucial. Evidence-based management of chronic groin pain is poorly studied, although cryotherapy and neuromodulation techniques show potential efficacy. (Source: Techniques in Regional Anesthesia and Pain Management)

Percutaneous Computed Tomography-guided Cryotherapy of Thoracic Masses in Nonsurgical Candidates: Experience in 19 Patients.

J Formos Med Assoc — Thu, 30 Jun 2011 23:00:00 +0100

We report the experience and outcomes with percutaneous computed tomography (CT)-guided cryotherapy of primary lung malignancies, as well as recurrence and metastases, in patients ineligible for surgery. PMID: 21742250 [PubMed - in process] (Source: J Formos Med Assoc)

Cervical endometriosis: clinical character and management experience in a 27-year span

American Journal of Obstetrics and Gynecology — Mon, 27 Jun 2011 04:00:00 +0100

Conclusion: Cervical endometriosis should be distinguished from other benign or malignant cervical lesions. Surgical excision is suggested for symptomatic patients. (Source: American Journal of Obstetrics and Gynecology)

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Indeterminate Cell Histiocytosis in a Pediatric Patient: Successful Treatment with Thalidomide.

Pathology Oncology Research — Sat, 18 Jun 2011 23:00:00 +0100

Authors: Tóth B, Katona M, Hársing J, Szepesi A, Kárpáti S The 15-year-old male patient presented several 2-6 mm large livid reddish-yellowish, shiny, compact papules on the head, trunk and extremities, which had developed within the last 4 months. Histology showed normal epidermis with dense dermal infiltrate of histiocytes accompanied by few eosinophils, Touton or foamy giant cells. The histiocytes were S100 positive, CD1a negative and did not contain Birbeck granules ultrastructurally. Chest X ray, EEG, skull MRI did not show pathology. Opthalmology, neurology, oto-rhino-laryngology did not reveal alterations. Based upon the clinical symptoms and the histopathology, the diagnosis of indeterminate cell histiocytosis was confirmed. Cryotherapy and cauterization did not stop the ...

No-fault compensation for treatment injury in New Zealand: identifying threats to patient safety in primary care

Quality and Safety in Health Care — Fri, 17 Jun 2011 23:00:00 +0100

Conclusions New Zealand's no-fault treatment injury claims database provides information about primary care patient safety events from an unusual ‘no-fault’ perspective. This analysis reinforces previous research identifying medication as a high-risk primary care activity and further identifies other primary care activities (dental care, injections, venepuncture, cryotherapy and ear syringing) as carrying important risks for patient harm. (Source: Quality and Safety in Health Care)

Percutaneous local ablation of unifocal subclinical breast cancer: clinical experience and preliminary results of cryotherapy

European Radiology — Fri, 17 Jun 2011 11:58:48 +0100

Conclusion The percutaneous cryoablation as a “minimally invasive” technique can provide excellent oncological and cosmetic results on selected cases handled by experienced operators by using the tested devices. Content Type Journal ArticlePages 1-10DOI 10.1007/s00330-011-2179-2Authors Guglielmo Manenti, Department of Diagnostic Imaging and Interventional Radiology, Molecular Imaging and Radiotherapy, University Hospital “Tor Vergata”, viale Oxford 81, 00133 Rome, ItalyTommaso Perretta, Department of Diagnostic Imaging and Interventional Radiology, Molecular Imaging and Radiotherapy, University Hospital “Tor Vergata”, viale Oxford 81, 00133 Rome, ItalyEleonora Gaspari, Department of Diagnostic Imaging and Interventional Radiology, Molecular Imaging and Ra...

How to perform antral pulmonary venous isolation using the cryoballoon

Heart Rhythm — Thu, 16 Jun 2011 23:00:00 +0100

This article describes our current practice, clinical outcomes, and future directions for the use of balloon cryoablation for the treatment of atrial fibrillation. Consensus exists that pulmonary venous (PV) isolation, preferably at an antral level, should be the cornerstone of any atrial fibrillation (AF) ablation procedure. However, most operators agree that the widely used technique of point-by-point ablation around PV antra is not ideal. Novel catheter designs that deliver circumferential ablation centered on PV ostia have the potential to reduce procedural times and complexity while delivering at least comparable clinical outcomes. One such technology, the cryoablation balloon, has been in use in Europe since 2005 and recently received U.S. Food and Drug Administration approval in 20...

Highlights from this issue

British Journal of Ophthalmology — Wed, 15 Jun 2011 23:00:00 +0100

Trabeculectomy with mitomycin C in advanced glaucoma Stead and King determined the medium-term intraocular pressure (IOP) control and visual outcomes in 103 patients with advanced glaucoma (MD –20 dB or above) undergoing trabeculectomy with mitomycin C. At 5 years, 85% had IOP of <16 mm Hg, and 96% had an IOP of <21 mm Hg. Mean MD for the group as a whole and for individual patients remained stable. Twenty-seven per cent patients experienced a significant reduction in acuity (attributable to trabeculectomy in about 10% of cases). The only preoperative determinant for reduction in VA was a low preoperative MD. (See page 960) Adjuvant 5-fluorouracil for localised OSSN Rudkin and Muecke prospectively studied outcome of localised non-invasive ocular su...

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Adjuvant 5-fluorouracil in the treatment of localised ocular surface squamous neoplasia

British Journal of Ophthalmology — Wed, 15 Jun 2011 23:00:00 +0100

Conclusions The management of localised non-invasive OSSN with adjuvant 5-FU 1% was associated with a low rate of local recurrence. Although 5-FU 1% frequently results in short-term complications, most commonly lid toxicity, a full course is usually tolerated. Serious complications appear uncommon in the treatment of localised disease. (Source: British Journal of Ophthalmology)

Ablative Therapies for Colorectal Liver Metastases (CRLM): a Systematic Review

Colorectal Disease — Mon, 13 Jun 2011 23:00:00 +0100

Conclusion; Ablative therapies offer significantly improved survival compared to palliative chemotherapy alone with 5‐year survival rates of 17‐24%. Complication rates amongst commonly used techniques are low. (Source: Colorectal Disease)

Evolution in Regression Patterns Following Chemoreduction for Retinoblastoma [Clinical Sciences]

Archives of Opthalmology — Sun, 12 Jun 2011 23:00:00 +0100

Conclusion Following chemoreduction and tumor consolidation therapy, retinoblastoma regression patterns types 2 and 3 can slowly evolve over time into a slightly different appearance, even without additional treatment. Ophthalmologists should be familiar with these regression patterns and their evolution. (Source: Archives of Opthalmology)

Periocular Topotecan for Intraocular Retinoblastoma [Clinical Sciences]

Archives of Opthalmology — Sun, 12 Jun 2011 23:00:00 +0100

Conclusion Periocular topotecan in fibrin sealant can achieve volume reduction of small and recurrent retinoblastoma sufficient to allow successful focal therapy. (Source: Archives of Opthalmology)

Cryotherapy versus salicylic acid for the treatment of plantar warts (verrucae): a randomised controlled trial

BMJ Online First — Mon, 06 Jun 2011 23:00:00 +0100

Objective To compare the clinical effectiveness of cryotherapy versus salicylic acid for the treatment of plantar warts. Design A multicentre, open, two arm randomised controlled trial. Setting... (Source: BMJ Online First)

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Bevacizumab for Coats' disease with exudative retinal detachment and risk of vitreoretinal traction.

The British Journal of Ophthalmology — Mon, 06 Jun 2011 23:00:00 +0100

Conclusion Coats' disease treated with intravitreal bevacizumab in addition to standard therapy can develop to vitreoretinal fibrosis and potentially traction retinal detachment. These tractional features are not often found in Coats' disease treated with standard measures without bevacizumab. Caution is advised in the use of bevacizumab for patients with Coats' disease. PMID: 21653215 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)

Surgical Treatments for Lentigo Maligna: A Review

Dermatologic Surgery — Tue, 31 May 2011 23:00:00 +0100

CONCLUSIONS SSE and MMS are associated with the lowest recurrence rates for LM. Cryotherapy and radiation therapy may be considered the options for treatment of LM in patients who cannot tolerate surgery. Imiquimod, although not currently approved by the FDA, has shown some efficacy in limited experimental studies and may play a future role in the treatment of LM.The authors have indicated no significant interest with commercial supporters. (Source: Dermatologic Surgery)

Image‐guided transnasal cryoablation of a recurrent nasal adenocarcinoma in a dog

The Journal of Small Animal Practice — Tue, 31 May 2011 23:00:00 +0100

An eight‐year‐old female spayed Airedale terrier with rapid recurrence of a nasal adenocarcinoma following image‐guided intensity‐modulated radiation therapy was treated with transnasal, imageguided cryotherapy. Ice ball size and location were monitored real‐time with computed tomography‐fluoroscopy to verify that the entire tumour was enveloped in ice. Serial computed tomography scans demonstrated reduction in and subsequent resolution of the primary tumour volume corresponding visually with the ice ball imaged during the ablation procedure. Re‐imaging demonstrated focallysis of the cribriform plate following ablation that spontaneously resolved by 13 months. While mild chronic nasal discharge developed following cryoablation, no other clinical signs of local nasal neoplasia...

Endoscopic cryotherapy of lung and bronchial tumors: a systematic review.

The Korean Journal of Internal Medicine — Tue, 31 May 2011 23:00:00 +0100

Authors: Lee SH, Choi WJ, Sung SW, Kim YK, Kim CH, Zo JI, Park KJ We made a systematic review and evaluation of endoscopic cryotherapy of endobronchial tumors, investigating safety and efficacy. PMID: 21716589 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)

The endoscopic cryotherapy of lung and bronchial tumors: a systematic review -can we expect a new era of cryotherapy in lung cancer?

The Korean Journal of Internal Medicine — Tue, 31 May 2011 23:00:00 +0100

Authors: Lee J, Park YS, Yang SC PMID: 21716587 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)

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Primary localized cutaneous nodular amyloidosis successfully treated with cyclophosphamide

Australasian Journal of Dermatology — Sun, 29 May 2011 23:00:00 +0100

We present a case of a middle‐aged woman with PLCNA associated with CREST (calcinosis, Raynaud phenomenon, oesophageal motility disorders, sclerodactyly and telangiectasia) syndrome and Sjögren's syndrome responding to cyclophosphamide with no new amyloid deposits and resolution of skin ulceration after many years of resistance to drug therapy. It is important to monitor these patients for progression into systemic amyloidosis. (Source: Australasian Journal of Dermatology)

Cervical screening strategies in resourced and resource-constrained countries

Best Practice and Research. Clinical Obstetrics and Gynaecology — Sun, 29 May 2011 23:00:00 +0100

Screening for cervical cancer is well established in resourced countries, but in resource-constrained countries, it is almost non-existent at national level. In resourced countries, the Pap test forms the hallmark of screening, with the human papillomavirus DNA test a recent adjunct. In many resourced countries, however, screening for cervical cancer is still far from ideal. A coverage around 50% prevails in some countries, and few have reached the target of 80% or more. Furthermore, the human papillomavirus test and newly developed biomarkers may lead to the development of a ‘super test’, which could be applied less frequently compared with present-day cytological screening. In resource-constrained countries, the movement is towards a ‘screen and treat’ approach. The main screenin...

CIN....Not Just a Fancy Pinguecula

Optometry - Journal of the American Optometric Association — Fri, 27 May 2011 16:06:15 +0100

Conjunctival intraepithelial neoplasia (CIN) is a unilateral, premalignant condition. It usually presents in late adult life and affects fair-skinned individuals. Predisposing factors include exposure to sunlight, human papillomavirus, and AIDS. CIN may clinically appear as a fleshy mass or leukoplakia most often located at or near the limbus but can extend into the adjacent cornea. It is a part of a spectrum of ocular surface neoplasia ranging from mild dysplasia to full-thickness replacement with dysplastic cells. Standard treatment involves excision with cryotherapy but other modalities include the use of topical mitomycin C, 5-fluorouracil, and interferon alpha-2b. (Source: Optometry - Journal of the American Optometric Association)

Cryotherapy using melamine foam of warts – An easy and rapid new trial method instead of cotton‐tipped applicator: a case series of 13 patients

International Journal of Dermatology — Fri, 20 May 2011 15:49:53 +0100

(Source: International Journal of Dermatology)

Optimal Freeze Cycle Length for Renal Cryotherapy

The Journal of Urology — Thu, 19 May 2011 23:00:00 +0100

Conclusions: There was no difference in immediate cellular necrosis among double 1, 5 or 10-minute freeze cycles. Cellular necrosis was evident on histological analysis for trials in which −20C was attained and in freeze cycles based on time alone. With a standard 10-minute cryoablation period most treated parenchyma 1 cm from the probe never attained −20C. Cell death appeared to occur at temperatures warmer than −20C during renal cryotherapy. (Source: The Journal of Urology)

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The effect of a cryotherapy gel wrap on the microcirculation of skin affected by chronic venous disorders

Journal of Advanced Nursing — Tue, 17 May 2011 23:00:00 +0100

Conclusion. Study findings suggest that cryotherapy improves blood flow by slowing movement within the microcirculation and thus might potentially provide a therapeutic benefit to prevent leg ulcers. (Source: Journal of Advanced Nursing)

Image Guided Percutaneous Probe Ablation for Renal Tumors in 65 Solitary Kidneys: Functional and Oncological Outcomes

The Journal of Urology — Sun, 15 May 2011 23:00:00 +0100

Conclusions: Computerized tomography guided percutaneous probe ablation represents a safe treatment option in surgical patients at high risk with a solitary kidney. It provides low morbidity, acceptable short-term cancer control and minimal clinical impact on postoperative renal function. (Source: The Journal of Urology)

The Role of 3-Dimensional Mapping Biopsy in Decision Making for Treatment of Apparent Early Stage Prostate Cancer

The Journal of Urology — Sun, 15 May 2011 23:00:00 +0100

Conclusions: Three-dimensional mapping biopsy revealed that a significant portion of men initially diagnosed with apparently low risk disease harbored clinically significant cancers requiring more aggressive therapy. The technique also enabled a number of men with low risk disease to elect surveillance or another less morbid option. (Source: The Journal of Urology)

Post-operative hilotherapy in SMAS-based facelift surgery: A prospective, randomised, controlled trial

Journal of Plastic, Reconstructive and Aesthetic Surgery — Thu, 12 May 2011 23:00:00 +0100

Conclusion: In this randomised, controlled trial the Hilotherapy mask produced significant facial skin cooling after SMAS-based facelift surgery at the expense of a statistically significant increase in patient reported post-operative swelling. No objective benefits were derived in terms of reducing ecchymosis, haematoma or pain. (Source: Journal of Plastic, Reconstructive and Aesthetic Surgery)

Role of imaging and biopsy to assess local recurrence after definitive treatment for prostate carcinoma (surgery, radiotherapy, cryotherapy, HIFU)

World Journal of Urology — Sat, 07 May 2011 15:44:59 +0100

Conclusion It is likely that imaging will be extensively used in the future to detect and localize prostate cancer local recurrences before salvage treatment. Content Type Journal ArticlePages 1-11DOI 10.1007/s00345-011-0687-yAuthors Pasquale Martino, Department of Emergency and Organ Transplantation-Urology I, University “Aldo Moro”, Bari, ItalyVincenzo Scattoni, Department of Urology, Vita Salute San Raffaele-University, Milan, ItalyAndrea B. Galosi, Institute of Urology, Azienda Ospedaliero-Universitaria, Ospedali Riuniti, Ancona, ItalyPaolo Consonni, Multimedica Hospital, Castellanza, Varese, ItalyCarlo Trombetta, Department of Urology, University of Trieste-Cattinara Hospital, Trieste, ItalySilvano Palazzo, Department of Emergency and Organ Transplantation-U...

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Lupoid leishmaniasis of the nose responding well to cryotherapy

Dermatologic Therapy — Sat, 30 Apr 2011 23:00:00 +0100

(Source: Dermatologic Therapy)

Intralesional vincristine combined with cryotherapy for recalcitrant verrucas

Dermatologic Therapy — Sat, 30 Apr 2011 23:00:00 +0100

ABSTRACTVerrucas are often recalcitrant to conventional cryotherapy. Since 1970, intralesional bleomycin has been used off‐label by dermatologists. But in some cases, the results of intralesional bleomycin were disappointing. Vincristine is a well‐known vinca alkaloid antiblastic drug that has been used for treating hematological neoplasm and nephroblastomas. It was reported good efficacy of intralesional vincristine for treating nodular lesion in classic Kaposi sarcoma. Its use in epithelial neoplasm and Kaposi sarcoma may support its efficacy in recalcitrant verrucas. The three patients selected for the study presented severe verrucas on foot, and they had already undergone cryotherapy several times and there was no improvement. They got intralesional vincristine injection on their v...

Treatment profile and complications associated with cryotherapy for localized prostate cancer: A population-based study

Prostate Cancer and Prostatic Diseases — Mon, 25 Apr 2011 23:00:00 +0100

Authors: C B Roberts, T L Jang, Yu-Hsuan Shao, S Kabadi, D F Moore & G L Lu-Yao (Source: Prostate Cancer and Prostatic Diseases)

Thermography study of skin response due to whole‐body cryotherapy

Skin Research and Technology — Wed, 20 Apr 2011 23:00:00 +0100

Conclusion: The magnitude of skin temperature decrease due to the extremely low temperature used in whole‐body cryotherapy may be connected to a patient's BMI. (Source: Skin Research and Technology)

Disseminated superficial actinic porokeratosis treated effectively with topical imiquimod 5% cream

Clinical And Experimental Dermatology — Tue, 19 Apr 2011 23:00:00 +0100

SummaryA 68‐year‐old man presented with a 3‐year history of asymptomatic red marks on his limbs. On physical examination, he was found to have numerous circular, erythematous macules with a fine peripheral rim of scale on his upper arms and legs. A clinical diagnosis of disseminated superficial actinic porokeratosis (DSAP) was made. On histopathological examination of the lesional skin on the hands, an angulated parakeratotic tier was seen extending up through the epidermis. The patient was offered a trial of topical imiquimod 5% cream. He was instructed to apply it five times weekly for 6 weeks to the right forearm. This produced a dramatic inflammatory response with painful superficial ulceration of the affected skin after 4 weeks. At follow‐up a further 4 weeks later, the ...

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Rapid response to acitretin, combined with cryotherapy, for extensive and recalcitrant verruca vulgaris on the scalp

Indian Journal of Dermatology, Venereology and Leprology — Mon, 18 Apr 2011 23:00:00 +0100

Feroze Kaliyadan, AD DharmaratnamIndian Journal of Dermatology, Venereology, and Leprology 2011 77(3):338-340 (Source: Indian Journal of Dermatology, Venereology and Leprology)

Comparison of cryotherapy and photodynamic therapy in treatment of oral leukoplakia

Photodiagnosis and Photodynamic Therapy — Sat, 16 Apr 2011 06:58:49 +0100

Background: Oral leukoplakia is a pre-malignant lesion of the oral mucosa. The aim of this study is to compare the curative effects of photodynamic therapy and cryotherapy in the treatment of oral leukoplakia. (Source: Photodiagnosis and Photodynamic Therapy)

Place of cryotherapy, argon plasma coagulation? Photodynamic therapy and stents in therapeutic bronchoscopy of lung cancers

Photodiagnosis and Photodynamic Therapy — Sat, 16 Apr 2011 06:58:31 +0100

Introduction/Background: Cryotherapy, argon plasma coagulation (APC), photodynamic therapy (PDT) and stents are different methods proposed with palliative intent in inoperable patients with centrally located lung cancers. It is very important to be combined with debulking surgery (APC and cryotherapy) and PDT. This aim of this study is to explore the efficacy and safety of the combination of these endoscopic methods in the treatment of malignant airway tumors. (Source: Photodiagnosis and Photodynamic Therapy)

Comparative study of 23-gauge vitrectomy versus 20-gauge vitrectomy for the treatment of rhegmatogenous retinal detachment

Graefe's Archive for Clinical and Experimental Ophthalmology — Fri, 15 Apr 2011 15:51:19 +0100

Conclusions Twenty-three-gauge PPV provides anatomical and visual results similar to the 20-G technique for the management of uncomplicated rhegmatogenous RD. Content Type Journal ArticlePages 1-10DOI 10.1007/s00417-011-1645-5Authors Magali Albrieux, Department of Ophthalmology, University Hospital of Grenoble, Joseph Fourier University, Grenoble, FranceFrédéric Rouberol, Department of Ophthalmology, University Hospital of Lyon, Hospices Civils de Lyon, Claude Bernard Lyon University, Lyon, FranceDiane Bernheim, Department of Ophthalmology, University Hospital of Grenoble, Joseph Fourier University, Grenoble, FranceJean-Paul Romanet, Department of Ophthalmology, University Hospital of Grenoble, Joseph Fourier University, Grenoble, FranceChristophe Chiquet, Departme...

Fire and Ice: Percutaneous Ablative Therapies and Cement Injection in Management of Metastatic Disease of the Spine

Seminars in Musculoskeletal Radiology — Thu, 14 Apr 2011 23:00:00 +0100

Semin Musculoskelet Radiol 2011; 15: 125-134DOI: 10.1055/s-0031-1275595ABSTRACTOncology intervention is actively moving beyond simple bone cement injection. Archimedes taught us that a volume displaces its volume. Where does the tumor we displace with our cement injection go? It is no longer acceptable that we displace tumor into the venous system with our cement injections. We must kill the tumor first. Different image-guided percutaneous techniques can be used for treatment in patients with primary or secondary bone tumors. Curative ablation can be applied for the treatment of specific benign or in selected cases of malignant localized spinal tumors. Pain palliation therapy of primary and secondary bone tumors can be achieved with safe, fast, effective, and tolerable percutaneous methods...

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Design considerations for a novel MRI compatible manipulator for prostate cryoablation

International Journal of Computer Assisted Radiology and Surgery — Tue, 12 Apr 2011 06:01:33 +0100

Conclusions A novel cryoablation procedure based on the use of a robotic assistant is proposed. The device design was presented with demonstration of MRI compatibility. Further developments include automatic registration and in vivo experimental testing. Content Type Journal ArticlePages 1-9DOI 10.1007/s11548-011-0558-4Authors S. Abdelaziz, LSIIT-CNRS Strasbourg University, Strasbourg, FranceL. Esteveny, LSIIT-CNRS Strasbourg University, Strasbourg, FranceP. Renaud, LSIIT-CNRS Strasbourg University, Strasbourg, FranceB. Bayle, LSIIT-CNRS Strasbourg University, Strasbourg, FranceL. Barbé, LSIIT-CNRS Strasbourg University, Strasbourg, FranceM. De Mathelin, LSIIT-CNRS Strasbourg University, Strasbourg, FranceA. Gangi, LSIIT-CNRS Strasbourg University, Strasbourg, Franc...

Effects of whole‐body cryotherapy (−110 °C) on proprioception and indices of muscle damage

Scandinavian Journal of Medicine and Science in Sports — Thu, 07 Apr 2011 23:00:00 +0100

The purpose of this study was to investigate the effects of whole‐body cryotherapy (WBC) on proprioceptive function, muscle force recovery following eccentric muscle contractions and tympanic temperature (TTY). Thirty‐six subjects were randomly assigned to a group receiving two 3‐min treatments of −110 ± 3 °C or 15 ± 3 °C. Knee joint position sense (JPS), maximal voluntary isometric contraction (MVIC) of the knee extensors, force proprioception and TTY were recorded before, immediately after the exposure and again 15 min later. A convenience sample of 18 subjects also underwent an eccentric exercise protocol on their contralateral left leg 24 h before exposure. MVIC (left knee), peak power output (PPO) during a repeated sprint on a cycle ergometer and muscles soreness w...

Cryosurgery as primary treatment for localized prostate cancer

International Urology and Nephrology — Thu, 07 Apr 2011 17:08:56 +0100

Conclusion Early results suggest that cryotherapy offers a safe and effective alternative for the primary treatment of localized prostate cancer. Additional studies with longer follow-up are necessary to determine the sustained efficacy of this procedure. Content Type Journal ArticlePages 1-6DOI 10.1007/s11255-011-9952-7Authors Huibo Lian, Department of Urology, Affiliated Drum Tower Hospital, Medical College of Nanjing University, Zhong-Shan Road No. 321, 210008 Nanjing, Jiangsu, ChinaHongqian Guo, Department of Urology, Affiliated Drum Tower Hospital, Medical College of Nanjing University, Zhong-Shan Road No. 321, 210008 Nanjing, Jiangsu, ChinaWeidong Gan, Department of Urology, Affiliated Drum Tower Hospital, Medical College of Nanjing University, Zhong-Shan Road ...

Editorial Comment

Urology — Thu, 31 Mar 2011 23:00:00 +0100

Readers of this journal understand that there are many treatment approaches for localized prostate cancer. Commonly used treatments include radical prostatectomy, external beam radiotherapy, interstitial brachytherapy, and cryotherapy. In the absence of large randomized trials comparing 1 treatment with another, physicians and patients alike are left with very little high-quality evidence to inform decision making. Suffice to say that the treatment of early stage prostate cancer is 1 of the most controversial areas in all of oncology. (Source: Urology)

Platelet-Rich Plasma Injection for Partial Patellar Tendon Tear in a High School Athlete: A Case Presentation

PM and R — Thu, 31 Mar 2011 23:00:00 +0100

Patellar tendinosis, also referred to as jumper's knee, is most commonly seen in elite athletes who participate in sports that involve jumping and directional changes. The prevalence has been estimated to be as high as 35%-40% in elite basketball players []. Histopathologic and biochemical evidence has indicated that the underlying pathology of tendinopathy is not inflammatory tendonitis but rather degenerative tendinosis []. Tensile overloading may cause microtearing of the tendon fibers followed by a focal degeneration. The onset is usually insidious and may relate to an increase in training intensity. Jumper's knee is often refractory to currently available treatments, including relative rest, exercise (with a focus on repetitive eccentric loading), bracing, nonsteroidal anti-inflammato...

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Cutaneous leishmaniasis in three Dutch military cohorts following jungle training in Belize

Travel Medicine and Infectious Disease — Wed, 30 Mar 2011 23:00:00 +0100

Summary: Skin lesions occur frequently in travelers to tropical countries. Military personnel acquire skin lesions regularly during jungle training as did Dutch troops who trained in the jungle of Belize in 1998, 2004 and 2009, in an area endemic for cutaneous leishmaniasis.Demographic and clinical data were collected retrospectively. Diagnostic investigations for cutaneous leishmaniasis included Giemsa stain, culture, PCR and NASBA and histopathology of biopsies. Treatment of leishmaniasis was with sodium stibogluconate, given intravenously or intralesionally, the latter with cryotherapy.In 1998 and 2004 cutaneous leishmaniasis due to Leishmania braziliensis and Leishmania mexicana infection was diagnosed in 25 persons out of 99 (attack rate 25.2%) and 14 persons out of 80 (attack rate 17...

Favorable effects of left ventricular reconstruction in patients excluded from the Surgical Treatments for Ischemic Heart Failure (STICH) trial

The Journal of Thoracic and Cardiovascular Surgery — Wed, 30 Mar 2011 05:28:05 +0100

Conclusions: With minimal associated mortality, left ventricular reconstruction produces durable improvement in left ventricular function in patients with a large scarred ventricular wall. Considering that this patient cohort would have been systematically excluded from the STICH trial, care should be taken not to extrapolate that study’s results too widely so as to inappropriately deny selected patients an effective treatment for ischemic cardiomyopathies with an injured ventricle. (Source: The Journal of Thoracic and Cardiovascular Surgery)

A Random Control Trial of Contrast Baths and Ice Baths for Recovery during Competition in U/20 Rugby Union

Journal of Strength and Conditioning Research — Tue, 29 Mar 2011 23:07:14 +0100

Higgins, TR, Heazlewood, IT, and Climstein, M. A random control trial of contrast baths and ice baths for recovery during competition in U/20 rugby union. J Strength Cond Res 25(4): 1046-1051, 2011-Players in team sports must recover in a relatively short period of time to perform at optimal levels. To enhance recovery, cryotherapy is widely used. To date, there are limited scientific data to support the use of cryotherapy for recovery. Players (n = 26) from a premier rugby club volunteered to participate in a random control trial (RCT) using contrast baths, ice baths, and no recovery. Statistical analysis, between group and within group, with repeated measures was conducted along with determination of effect sizes in 2 field tests. Pre and postfield tests including a 300-m test and a phos...

Reply

American Journal of Ophthalmology — Tue, 29 Mar 2011 20:50:06 +0100

We appreciate the correspondence from Drs Tornambe and Grizzard and their highlighting the results of the Pneumatic Retinopexy Clinical Trial. As is true with all of medicine, results in the real world generally are different from the controlled parameters of a clinical trial, as evidenced in our findings. We agree with the statement of limitations made in our article and the letter about the use of claims data, and we wish to emphasize the limitations noted in our article. To address one of the questions in the letter, we did distinguish the type of second procedure after pneumatic retinopexy (please see Table 3, which shows that after initial pneumatic retinopexy, 10.9% of patients underwent further laser or cryotherapy and 5.8% had another pneumatic retinopexy). With regard to cost effe...

Cryotherapy for Barrett's esophagus: does the gas really matter?

Endoscopy — Mon, 28 Mar 2011 23:00:00 +0100

EndoscopyDOI: 10.1055/s-0030-1256332© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text (Source: Endoscopy)

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A pilot study of endoscopic spray cryotherapy by pressurized carbon dioxide gas for Barrett's esophagus

Endoscopy — Thu, 24 Mar 2011 00:00:00 +0100

EndoscopyDOI: 10.1055/s-0030-1256334Background and study aims: Endoscopic spray cryoablation is a novel approach for the treatment of Barrett's esophagus. However, few studies have reported its efficacy, especially with the use of carbon dioxide (CO2). The aim of the current study was to evaluate the short term efficacy and complications using CO2 in endoscopic cryoablation of Barrett's esophagus.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Abstract | Full text (Source: Endoscopy)

Enucleation and Liquid Nitrogen Cryotherapy in the Treatment of Keratocystic Odontogenic Tumors: A Case Series

Journal of Oral and Maxillofacial Surgery — Mon, 21 Mar 2011 00:00:00 +0100

Conclusions: This study confirmed the efficiency of KOT treatment enucleation without fragmentation combined with liquid nitrogen cryotherapy at the surgical site. (Source: Journal of Oral and Maxillofacial Surgery)

Sorafenib‐induced premalignant and malignant skin lesions

International Journal of Dermatology — Fri, 18 Mar 2011 16:30:58 +0100

Conclusions The possibility of rapidly developing actinic keratoses, keratocanthomas, verrucas, and SCC during treatment with sorafenib, warrants close dermatologic follow‐up and a lower threshold for biopsy and treatment of suspicious cutaneous lesions. Development of a sorafenib‐induced SCC is not an absolute contraindication for continued use of sorafenib therapy; however, the drug should be briefly discontinued until lesions are treated. (Source: International Journal of Dermatology)

The Future of Nephron Sparing Procedures for Renal Masses: Balancing Costs, Efficacy, Patient Outcomes and Experience

The Journal of Urology — Fri, 18 Mar 2011 00:00:00 +0100

There has been a significant increase in the incidence of renal cell carcinoma (RCC) primarily involving small renal tumors less than 4 cm. Management of these small renal masses involves multiple options including radical nephrectomy (open or laparoscopic), partial nephrectomy (open, laparoscopic or robot-assisted), laparoscopic or percutaneous ablation (cryotherapy or radio frequency), or observation. The population who typically presents with small renal masses is older and frequently has multiple comorbidities. Issues in these patients often mirror those in patients with low grade prostate cancer. Decisions are required to determine which patient should get treated and how to balance treatment morbidities with efficacy. There is recognition that approximately 80% of small renal masses ...

Confocal Microscopy of Recurrent Naevi and Recurrent Melanomas: a Retrospective MORPHOLOGIC Study

British Journal of Dermatology — Thu, 17 Mar 2011 00:00:00 +0100

Conclusions: The integration of clinical, dermoscopic and RCM aspects offer the possibility to reliably discern the nature in case of re‐pigmentation on a scar. (Source: British Journal of Dermatology)

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Confocal Microscopy of Recurrent Naevi and Recurrent Melanomas: a Retrospective MORPHOLOGIC Study.

The British Journal of Dermatology — Thu, 17 Mar 2011 00:00:00 +0100

Conclusions: The integration of clinical, dermoscopic and RCM aspects offer the possibility to reliably discern the nature in case of re-pigmentation on a scar. PMID: 21410674 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)

Confocal microscopy of recurrent naevi and recurrent melanomas: a retrospective morphological study

British Journal of Dermatology — Thu, 17 Mar 2011 00:00:00 +0100

Conclusions The integration of clinical, dermoscopic and RCM aspects offers the possibility to discern reliably the nature in cases of repigmentation on a scar. (Source: British Journal of Dermatology)

Ablative Therapies of the Breast

Surgical Oncology Clinics of North America — Tue, 15 Mar 2011 19:02:16 +0100

Minimally invasive ablative therapy techniques are being used in research protocols to treat benign and malignant tumors of the breast in select patient populations. These techniques offer the advantages of an outpatient setting, decreased pain, and improved cosmesis. These therapies, including radiofrequency ablation, cryotherapy, interstitial laser therapy, high-intensity focused ultrasonography, and focused microwave thermotherapy, are reviewed in this article. (Source: Surgical Oncology Clinics of North America)

Letter From the Editor: The Scope of Interventional Radiology

Seminars in Roentgenology — Tue, 15 Mar 2011 18:28:45 +0100

The scope of procedures performed by interventional radiologists has changed dramatically in the last 20 years. Angiography was once a large part of an interventionalist's work but now is mostly performed by nonradiologists. Some image-guided procedures that were common 20 years ago are still performed in great numbers (eg, biliary interventions, needle biopsy of solid-organ tumors, percutaneous abscess drainage). However, there are now a multitude of new procedures, including chemoembolization, cryotherapy, treatment of varicose veins (phlebectomy, sclerotherapy, and endovenous ablation), radioembolization, radiofrequency ablation of solid-organ tumors, transjugular intrahepatic portosystemic shunt, uterine fibroid embolization, and varicocele embolization. This is not a complete list and...