MedWorm: Hyperbaric Oxygen Therapy

Hyberbaric oxygen increases atresia in normal & steroid induced PCO rat ovaries

Reproductive Biology and Endocrinology — Mon, 06 Feb 2012 05:00:00 +0100

Conclusions: HBOT of six weeks itself, changed ovarian morphology in favor of atresia both in PCO group and control group. This result of aggravated follicular atresia after HBOT on EV induced PCO may be due to long-term exposure in our protocol which with this state seems to be inapplicable in the improvement of PCO morphology. (Source: Reproductive Biology and Endocrinology)

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Hyperbaric O2 Helps Most Chronic Radiation Injuries: StudyHyperbaric O2 Helps Most Chronic Radiation Injuries: Study

Medscape Hematology-Oncology Headlines — Thu, 02 Feb 2012 11:19:19 +0100

Hyperbaric oxygen improves most cases of chronic radiation tissue injury, according to a large single-center report. Reuters Health Information (Source: Medscape Hematology-Oncology Headlines)

Targeting Quiescent Tumor Cells via Oxygen and IGF-I Supplementation

Cancer Research — Tue, 31 Jan 2012 05:00:00 +0100

In this study, we used a 3-dimensional tissue culture system to assay diffusible factors that can limit proliferation in the context of the tumor microenvironment, with the goal of identifying targets to heighten proliferative capacity in this setting. We found that supraphysiologic levels of insulin or insulin-like growth factor I (IGF-I) in combination with oxygen supplementation were sufficient to initiate proliferation of quiescence cells in this system. At maximal induction with IGF-I, net tissue proliferation increased 3- to 4-fold in the system such that chemotherapy could trigger a 3- to 6-fold increase in cytotoxicity, compared with control conditions. These effects were confirmed in vivo in colon cancer xenograft models with demonstrations that IGF-I receptor stimulation was suff...

Age-dependent response of murine female bone marrow cells to hyperbaric oxygen.

Biogerontology — Tue, 24 Jan 2012 05:00:00 +0100

Authors: Gomez CR, Knutson GJ, Clifton KB, Schreiber CA, Vuk-Pavlović S Abstract Consequences of age on the effects of hyperbaric oxygen (HBO) on bone marrow (BM) derived stem cells and progenitors (SCPs) are largely unknown. We treated 2- and 18-month old C57BL/6 female mice by HBO. Hematopoietic stem cells and progenitors, enumerated as colony-forming units in culture, were doubled only in peripheral leukocytes and BM cells of young mice receiving HBO. In old mice colony-forming unit fibroblast numbers, a measure of mesenchymal stromal cells (MSCs) from BM, were high but unaffected by HBO. To further explore this finding, in BM-MSCs we quantified the transcripts of adipocyte early-differentiation genes peroxisome proliferator-activated receptor-γ, CCAAT/enhancer binding protein...

Hyperbaric oxygen therapy improves peripheral insulin sensitivity in humans

Diabetic Medicine — Tue, 24 Jan 2012 05:00:00 +0100

Conclusion: Insulin sensitivity increased within 3 days of hyperbaric oxygen treatment and this was maintained for 30 sessions. This increase in insulin sensitivity is equivalent to that observed following moderate weight loss. The mechanisms underlying the insulin‐sensitizing effect of hyperbaric oxygen require further elucidation.© 2012 The Authors. Diabetic Medicine © 2012 Diabetes UK (Source: Diabetic Medicine)

Treatment of Fournier's Gangrene with Combination of Vacuum-Assisted Closure Therapy, Hyperbaric Oxygen Therapy, and Protective Colostomy

Clinical and Developmental Immunology — Mon, 23 Jan 2012 11:22:21 +0100

Fournier's gangrene is a rare process which affects soft tissue in the genital and perirectal area. It can also progress to all different stages of sepsis, and abdominal compartment syndrome can be one of its complications. Two patients in septic shock due to Fournier gangrene were admitted to the Intensive Care Unit of Emergency Department. In both cases, infection started from the scrotum and the necrosis quickly involved genitals, perineal, and inguinal regions. Patients were treated with surgical debridement, protective colostomy, hyperbaric oxygen therapy, and broad-spectrum antibacterial chemotherapy. Vacuum-assisted closure (VAC) therapy was applied to the wound with the aim to clean, decontaminate, and avoid abdominal compartmental syndrome development. Both patients survived and w...

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Hyperbaric Oxygen Therapy in Patients with Necrotizing Soft Tissue Infections: No Impact on Mortality or Amputation Rate

Journal of Surgical Research — Sat, 14 Jan 2012 22:30:14 +0100

(Source: Journal of Surgical Research)

The use of hyperbaric oxygen for treating delayed radiation injuries in gynecologic malignancies: a review of literature and report of radiation injury incidence

Supportive Care in Cancer — Fri, 13 Jan 2012 17:17:19 +0100

Conclusions There is level A evidence for using HBOT to treat radiation proctitis. There is level B evidence for using HBOT to treat radiation cystitis and necrosis. The incidence delayed radiation injuries can be as high as 23%. This has relevance in practice guidelines for the treatment of delayed radiation injuries in gynecologic malignancies. Content Type Journal ArticleCategory Original ArticlePages 1-6DOI 10.1007/s00520-012-1379-xAuthors Scott Allen, Medical College of Wisconsin, Milwaukee, WI 53226, USAChris Kilian, Medical College of Wisconsin, Milwaukee, WI 53226, USAJenise Phelps, Medical College of Wisconsin, Milwaukee, WI 53226, USAHarry T. Whelan, Medical College of Wisconsin, Milwaukee, WI 53226, USA Journal Supportive Care in CancerOnline ISSN ...

A Phase I Study of Low-Pressure Hyperbaric Oxygen Therapy for Blast-Induced Post-Concussion Syndrome and Post-Traumatic Stress Disorder

Journal of Neurotrauma — Mon, 09 Jan 2012 18:24:37 +0100

Journal of Neurotrauma Jan 2012, Vol. 29, No. 1: 168-185. (Source: Journal of Neurotrauma)

Osteoradionecrosis in irradiated patients

Dental Abstracts — Sun, 01 Jan 2012 05:00:00 +0100

Radiotherapy is an established treatment method for managing malignant disease of the head and neck. This modality targets all cells with a high turnover rate, regardless of whether they are malignant or normal tissues. The key to achieving a cure is to balance the eradication of tumor cells with the avoidance of further patient debilitation. The adverse effects on normal tissue limit the dose and delivery rate of radiotherapy. Osteoradionecrosis (ORN) is one of the most serious complications of radiotherapy. ORN is defined as an area of exposed devitalized irradiated bone that does not heal within 3 to 6 months with no local neoplastic disease. ORN is difficult to treat and is often associated with a poor outcome and deformity. ORN can be spontaneous, caused by periodontal and apical dise...

Practice guidance on the management of acute and chronic gastrointestinal problems arising as a result of treatment for cancer

Gut — Sat, 24 Dec 2011 05:00:00 +0100

Conclusions All cancer units must develop simple methods to identify the many patients who need help and establish routine referral pathways to specialist gastroenterologists where patients can receive safe and effective treatment. Early contact with oncologists and/or specialist surgeons with input from the patient's family and friends often helps the gastroenterologist to refine management strategies. Increased training in the late effects of cancer treatment is required. (Source: Gut)

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Necrotizing fasciitis: literature review of contemporary strategies for diagnosing and management with three case reports: torso, abdominal wall, upper and lower limbs

World Journal of Emergency Surgery — Fri, 23 Dec 2011 05:00:00 +0100

We describe three clinical cases with NF. The first is a 69 years old man with diabetes mellitus type II, who presented with NF on the posterior chest wall, shoulder and arm. He was admitted to the intensive care unit (ICU) with a clinical picture of severe sepsis. Outpatient treatment and early surgical debridement of the affected zones (inside 3 hours after admittance) and critical care therapy were performed. The second case is of a 63 years old paraplegic man with diabetes mellitus type I. Pressure sores and perineal abscesses progressed to Fournier's gangrene of the perineum and scrotum. He had NF of the anterior abdominal wall and the right thigh. Outpatient treatment and early surgical debridement of the affected zones (inside 6 hour after admittance) and critical care therapy were ...

Oxygen cycling in conjunction with stem cell transplantation induces NOS3 expression leading to attenuation of fibrosis and improved cardiac function

Cardiovascular Research — Mon, 19 Dec 2011 05:00:00 +0100

Conclusions The results showed that post-MI exposure of rats to daily cycles of hyperoxygenation (oxygen cycling) improved stem cell engraftment, cardiac function, and increased NOS3 expression. (Source: Cardiovascular Research)

The 2-nitroimidazole EF5 is a biomarker for oxidoreductases that activate the bioreductive prodrug CEN-209 under hypoxia.

Clinical Cancer Research — Tue, 13 Dec 2011 05:00:00 +0100

Conclusions. EF5 binding is a promising stratification biomarker for benzotriazine-N-oxide bioreductive prodrugs because of its potential for interrogating reductase activity as well as hypoxia in individual tumors. PMID: 22167409 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)

The evaluation of the effects of hyperbaric oxygen therapy on new bone formation obtained by distraction osteogenesis in terms of consolidation periods

Clinical Oral Investigations — Fri, 02 Dec 2011 06:48:16 +0100

Conclusion Hyperbaric oxygen therapy can be used to increase the quality and the quantity of bone and to decrease the maturation time which may shorten the consolidation period of vertical distraction osteogenesis. Clinical relevance The effect of hyperbaric oxygen therapy on vertical distraction osteogenesis procedure according to consolidation periods has been determined. Hyperbaric oxygen therapy may increase the quality and the quantity of bone and shorten the consolidation period. Content Type Journal ArticleCategory Original ArticlePages 1-8DOI 10.1007/s00784-011-0644-6Authors Ibrahim Mutlu, Ankara Mevki Military Hospital, Ankara, TurkeyYavuz Sinan Aydintug, Department of Oral and Maxillofacial Surgery, Gülhane Military Medical Academy (G...

Prospective assessment of outcomes in 411 patients treated with hyperbaric oxygen for chronic radiation tissue injury

Cancer — Fri, 02 Dec 2011 05:00:00 +0100

CONCLUSIONS:The outcomes of 411 patients collected prospectively over 8 years strongly supported the efficacy of hyperbaric oxygen treatment for the 6 conditions evaluated. The response rates previously reported in numerous small series were supported by the responses achieved in this large, single‐center experience. Cancer 2011. © 2011 American Cancer Society. (Source: Cancer)

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The development of hyperbaric and diving medicine in Singapore.

Singapore Medical Journal — Thu, 01 Dec 2011 05:00:00 +0100

Authors: Chng J, Low CT, Kang WL Abstract Hyperbaric oxygen therapy is a noninvasive therapy used in the treatment of diving-related medical illnesses. It is an important adjunct in the management of a variety of medical conditions. The Republic of Singapore Navy Medical Service (NMS) is the main driver of the development of hyperbaric and diving medicine in Singapore. The practice of hyperbaric medicine has inherent risks, and unregulated application of this therapy may do more harm than good. NMS and Singapore General Hospital (SGH) signed a Memorandum of Understanding to combine NMS' experience with the clinical expertise of SGH to provide holistic care for diving and clinical hyperbaric treatment patients. This collaboration would increase the profile of this clinical specialty...

Potential utility of hyperbaric oxygen therapy and propolis in enhancing the leishmanicidal activity of glucantime.

Revista do Instituto de Medicina Tropical de Sao Paulo — Thu, 01 Dec 2011 05:00:00 +0100

In this study we investigated the efficacy of hyperbaric oxygen (HBO) therapy, alone or combined with the pentavalent antimonial glucantime on Leishmania amazonensis infection. In parallel, the effect of Brazilian red propolis gel (propain) alone or combined with glucantime on L. amazonensis infection was evaluated. The inhibition of the infection in macrophages treated with glucantime in combination with HBO exposition was greater than that of macrophages treated with glucantime alone or HBO alone. The susceptible mouse strain BALB/c infected in the shaved rump with L. amazonensis treated with glucantime and exposed to HBO showed: time points in the course of the disease in which lesions were smaller than those of mice treated with glucantime alone and revascularization of the skin in the...

Research Shows Rx With Hyperbaric Oxygen Improved TBI And PTSD In Vets

Health News from Medical News Today — Wed, 30 Nov 2011 08:00:00 +0100

Research led by Dr. Paul Harch, Associate Clinical Professor of Medicine at LSU Health Sciences Center New Orleans, has found that treatment with hyperbaric oxygen nearly three years after injury significantly improved function and quality of life for veterans with traumatic brain injury and post-traumatic stress disorder. The findings are available online now in the Journal of Neurotrauma... (Source: Health News from Medical News Today)

LSUHSC research shows Rx with hyperbaric oxygen improved TBI and PTSD in vets

EurekAlert! - Social and Behavioral Science — Mon, 28 Nov 2011 05:00:00 +0100

(Louisiana State University Health Sciences Center) Research led by Dr. Paul Harch, associate clinical professor of medicine at LSU Health Sciences Center New Orleans, has found that treatment with hyperbaric oxygen nearly three years after injury significantly improved function and quality of life for veterans with traumatic brain injury and post-traumatic stress disorder. (Source: EurekAlert! - Social and Behavioral Science)

Neurotrophic Effects of Perfluorocarbon Emulsion Gel: A Pilot Study

Journal of Brachial Plexus and Peripheral Nerve Injury — Wed, 23 Nov 2011 05:00:00 +0100

Background: Positive neurotrophic effects of hyperbaric oxygen treatment may be more easily achieved by applying a Perflourocarbon (PFC) emulsion gel to the repair site. PFCs are halogen substituted carbon oils with unique oxygen transport potentials that are capable of increasing oxygen availability in local tissues. The purpose of this study was to determine if the application of a PFC emulsion to a repaired nerve would improve recovery.Materials and MethodsThe left tibial nerve of 21 immature female Sprague-Dawley rats was transected, immediately repaired, and then circumferentially coated with PFC gel (Group A, n=7), PFC-less gel (Group B, n=7), or nothing (suture only, Group C, n=7). At eight weeks post surgery, electrophysiological testing and histological and morphological analysis...

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A Phase I Study of Low-Pressure Hyperbaric Oxygen Therapy for Blast-Induced Post-Concussion Syndrome and Post-Traumatic Stress Disorder

Journal of Neurotrauma — Tue, 22 Nov 2011 14:26:51 +0100

Journal of Neurotrauma , Vol. 0, No. 0. (Source: Journal of Neurotrauma)

Kyphectomy for congenital kyphosis due to meningomyelocele: a case treated with a modified approach to skin healing

International Wound Journal — Sat, 19 Nov 2011 23:25:24 +0100

This study is a case report of a meningomyelocele patient with congenital kyphosis who was treated with kyphectomy and a special approach to soft tissue healing. The objective of this study is to show a step by step approach to surgical treatment and postoperative care of a meningomyelocele patient with congenital kyphosis. In meningomyelocele the incidence of kyphosis is around 12–20%. It may cause recurrent skin ulcerations, impaired sitting balance and respiratory compromise. Kyphectomy has first been described by Sharrard. This surgery is prone to complications including pseudoarthrosis, skin healing problems, recurrence of deformity and deep infections. A 15‐year‐old male presented with congenital kyphosis due to meningomyelocele. He had back pain, deformity and bedsores at the ...

Does hyperbaric oxygen have positive effect on neurological recovery in spinal-epidural haematoma?: a case report

British Journal of Anaesthesia — Wed, 16 Nov 2011 05:00:00 +0100

(Source: British Journal of Anaesthesia)

Clinical effectiveness of hyperbaric oxygen therapy for BK-virus-associated hemorrhagic cystitis after allogeneic bone marrow transplantation

Bone Marrow Transplantation — Mon, 14 Nov 2011 05:00:00 +0100

Authors: J Savva-Bordalo, C Pinho Vaz, M Sousa, R Branca, F Campilho, R Resende, I Baldaque, O Camacho & A Campos (Source: Bone Marrow Transplantation)

Hyperbaric oxygen therapy reduces the severity of ischaemia, preservation and reperfusion injury in a rat model of liver transplantation

HPB: official journal of the International Hepato Pancreat Biliary Association — Sun, 13 Nov 2011 05:00:00 +0100

Conclusions: Hyperbaric oxygen therapy has persistent positive effects post‐OLT that may potentially transfer into clinical practice. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)

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Is glucose-6-phosphate dehydrogenase deficiency a risk factor for hyperbaric oxygen exposure?

European Journal of Applied Physiology — Thu, 10 Nov 2011 16:47:32 +0100

Abstract Divers and patients lacking glucose-6-phosphate dehydrogenase (G6PD) may face a serious threat of central nervous system oxygen toxicity (CNS-OT) during exposure to hyperbaric oxygen (HBO), due to the important part played by G6PD in cellular redox balance. Our objective was to investigate G6PD deficiency as a risk factor for CNS-OT. We exposed G6PD-deficient (G6PDdef) and wild type (WT) mice to HBO at 405 kPa. Latency to CNS-OT was measured by observing the animal and monitoring the time to appearance of convulsions. Changes in glutathione peroxidase (GPx) and catalase activity were measured in red blood cells, and levels of endothelial and neuronal nitric oxide synthase (eNOS and nNOS) and 3-nitrotyrosine (NT) were measured in extracts of whole brain tissue...

Effect of hyperbaric oxygen therapy on the intestinal ischemia reperfusion injury.

Acta Cirurgica Brasileira — Fri, 04 Nov 2011 01:47:11 +0100

CONCLUSION: The hyperbaric oxygen therapy can limit tissue damage due to ischemia/reperfusion injury, by inducing reparative signaling pathways. PMID: 22042109 [PubMed - in process] (Source: Acta Cirurgica Brasileira)

Crohn's disease and hyperbaric oxygen therapy.

Acta Cirurgica Brasileira — Fri, 04 Nov 2011 01:45:03 +0100

CONCLUSION: HBO has shown benefits in patients with CD refractory to pharmacologic therapy. PMID: 22030829 [PubMed - in process] (Source: Acta Cirurgica Brasileira)

Hyperbaric oxygen for radiation injury

Dental Abstracts — Tue, 01 Nov 2011 04:00:00 +0100

The treatment of head and neck cancer with radiotherapy can be complicated by the development of osteoradionecrosis (ORN) of the jaws. However, before cancer treatment, ORN may be prevented or minimized as much as possible through good oral hygiene, careful preventative dental care, and extractions. The optimal dental management of patients before radiotherapy and the possible benefits of hyperbaric oxygen (HBO) before extractions for patients who have undergone radiotherapy were detailed. (Source: Dental Abstracts)

Hyperbaric oxygen therapy and optic neuritis: case report and literature review.

Undersea and Hyperbaric Medicine — Tue, 01 Nov 2011 04:00:00 +0100

We present a case report of a patient with a history of optic neuritis who underwent comprehensive ophthalmologic evaluation before and after 40 treatments with hyperbaric oxygen therapy, with no detectable ophthalmologic deficit. PMID: 22292261 [PubMed - in process] (Source: Undersea and Hyperbaric Medicine)

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Tissue oxygenation and microvascular hemodynamics in experimental arterial gas embolism.

Undersea and Hyperbaric Medicine — Tue, 01 Nov 2011 04:00:00 +0100

Authors: Torres LN, Spiess BD, Torres Filho IP Abstract Microvascular hemodynamic responses to arterial gas embolism (AGE) and local oxygen tensions (PO2) have never been evaluated in vivo using intravital microscopy. A system was implemented to study AGE in real time using brightfield and phosphorescence microscopy as well as laser-induced microvessel occlusion. Bubble dynamics, microhemodynamics and oxygenation were studied following AGE in 61 microvessels and 41 interstitial spaces from 19 anesthetized rats. AGE was induced by direct air injection into the femoral artery ipsilateral to the studied cremaster muscle. Bubble-induced vaso-occlusion was investigated, and microvascular blood flow redistribution were associated with changes in intravascular and interstitial PO2. Microv...

Stimulating angiogenesis by hyperbaric oxygen in an isolated tissue construct.

Undersea and Hyperbaric Medicine — Tue, 01 Nov 2011 04:00:00 +0100

CONCLUSIONS: Short-term HBO2 exposure appears to increase angiogenesis in isolated tissue constructs. Prolonged HBO2 exposure may lead to vascular pruning. Short-term HBO2 exposure appears to expedite the natural vascularization process, resulting in equivalent vascularization in a shorter time. PMID: 22292256 [PubMed - in process] (Source: Undersea and Hyperbaric Medicine)

The effect of hyperbaric oxygenation on the distal intestine of rats subjected to ionizing radiation.

Undersea and Hyperbaric Medicine — Tue, 01 Nov 2011 04:00:00 +0100

Authors: Aprilli RR, Parra RS, de Oliveira HF, Aprilli F, da Rocha JJ, Féres O Abstract The current study was to test an experimental model of actinic lesions in the distal intestine of rats and to determine the possible protective effect of hyperbaric oxygen therapy (HBO2) in radio-induced lesions when concomitantly applied with ionizing radiation. Twenty-four Wistar rats were divided into four groups: G1 (control group); G2 (animals irradiated); G3 (animals irradiated plus HBO2); G4 (only HBO2). The animals were evaluated for 28 days after the end of treatment and then euthanized. The distal intestine was resected for macroscopic and microscopic evaluation and immunohistochemistry. The animals in the G3 group lost weight during the treatment; all of the animals in the G2 group p...

Effects of early hyperbaric oxygen therapy on clinical outcome in postoperative patients with intracranial aneurysm.

Undersea and Hyperbaric Medicine — Tue, 01 Nov 2011 04:00:00 +0100

CONCLUSIONS: Early HBO2 appears to be beneficial asan adjunctive treatment of postoperative intracranial aneurysm. Attenuating postoperative CVS, brain edema, and cerebral ischemia contributes to the effectiveness of HBO2. PMID: 22292254 [PubMed - in process] (Source: Undersea and Hyperbaric Medicine)

Hyperbaric oxygen and muscle performance in maximal sustained muscle contraction.

Undersea and Hyperbaric Medicine — Tue, 01 Nov 2011 04:00:00 +0100

CONCLUSIONS: These data suggest that when performing sustained maximal contractions during acute exposure to HBO2, overall contractile force may be significantly increased compared with breathing normobaric air. Initial rate of fatigue is higher with HBO2, perhaps due to increased extravascular compression with the initial greater force production. PMID: 22292253 [PubMed - in process] (Source: Undersea and Hyperbaric Medicine)

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Intravital microscopy methods in microvascular blood flow and tissue oxygenation.

Undersea and Hyperbaric Medicine — Tue, 01 Nov 2011 04:00:00 +0100

Authors: Eckmann DM PMID: 22292252 [PubMed - in process] (Source: Undersea and Hyperbaric Medicine)

Hyperbaric oxygen and muscle performance in maximal sustained muscle contraction.

Undersea and Hyperbaric Medicine — Tue, 01 Nov 2011 04:00:00 +0100

Authors: Harrison MF PMID: 22292251 [PubMed - in process] (Source: Undersea and Hyperbaric Medicine)

Changes in inflammatory gene expression induced by hyperbaric oxygen treatment in human endothelial cells under chronic wound conditions.

Experimental Cell Research — Fri, 28 Oct 2011 04:00:00 +0100

Authors: Kendall AC, Whatmore JL, Harries LW, Winyard PG, Smerdon GR, Eggleton P Abstract Hyperbaric oxygen (HBO) therapy involves the inhalation of 100% oxygen, whilst inside a chamber at greater than atmospheric pressure. It is an effective treatment for chronic diabetic wounds, although the molecular mechanisms involved remain unclear. We hypothesised that HBO could alter inflammatory gene expression in human endothelial cells via a reactive oxygen/nitrogen species-mediated pathway. Endothelial cells were exposed to a chronic wound model comprising hypoxia (2% O(2) at 1 atmosphere absolute (ATA); PO(2) ~2kPa) in the presence of lipopolysaccharide and TNF-α for 24h, then treated with HBO for 90min (97.5% O(2) at 2.4 ATA; PO(2) ~237kPa). 5h post-HBO, 19 genes involved in adhesion...

Hyperbaric Oxygen Therapy as an Adjunctive Treatment for Sternal Infection and Osteomyelitis after Sternotomy and Cardiothoracic Surgery

Journal of Cardiothoracic Surgery — Mon, 17 Oct 2011 04:00:00 +0100

Conclusions: In addition to primary treatment with debridement and antibiotic use, HBO2 therapy may be used as an adjunctive and safe treatment to improve clinical outcomes in patients with sternal infection and osteomyelitis after sternotomy and cardiothoracic surgery. (Source: Journal of Cardiothoracic Surgery)

Utilization of Hyperbaric Oxygen Therapy and Induced Hypothermia After Hydrogen Sulfide Exposure.

Respiratory Care — Wed, 12 Oct 2011 04:00:00 +0100

We report the case of a patient presenting with cardiac arrest secondary to hydrogen sulfide exposure treated with both hyperbaric oxygen therapy and therapeutic hypothermia to achieve full neurologic recovery. PMID: 22004989 [PubMed - as supplied by publisher] (Source: Respiratory Care)

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Poster 120 Case Study of Five Patients with Severe Traumatic Brain Injuries that Underwent Hyperbaric Oxygen Treatment

Archives of Physical Medicine and Rehabilitation — Sat, 01 Oct 2011 04:00:00 +0100

The main objective for this chart review and case study was to identify both positive and negative outcomes related to hyperbaric oxygen treatment (HBOT) in patients with severe traumatic brain injury. (Source: Archives of Physical Medicine and Rehabilitation)

Heme oxygenase-1 could mediate the protective effects of hyperbaric oxygen preconditioning against hepatic ischemia-reperfusion injury in rats.

Clinical and Experimental Pharmacology and Physiology — Sat, 01 Oct 2011 04:00:00 +0100

In conclusion, HBO preconditioning can protect the liver against I/R injury and it appears that this effect might be mediated by the induction of HO-1. PMID: 21711378 [PubMed - in process] (Source: Clinical and Experimental Pharmacology and Physiology)

Use of adjunctive treatments in improving patient outcome in Fournier's gangrene.

Singapore Medical Journal — Sat, 01 Oct 2011 04:00:00 +0100

We report Fournier's gangrene in a 60-year-old diabetic man and his successful treatment with skin grafting, which utilised a multidisciplinary approach and adjuncts, including negative-pressure wound therapy and hyperbaric oxygen therapy. We also review the literature related to these adjuncts and discuss their usefulness in the management of NSTIs. PMID: 22009405 [PubMed - in process] (Source: Singapore Medical Journal)

Full Thickness Burns over Bilateral Patella Tendons - Adjunctive Hyperbaric Oxygen Therapy and Negative Pressure Wound Therapy for Wound Bed Preparation and Improved Graft Take.

Annals of the Academy of Medicine, Singapore — Sat, 01 Oct 2011 04:00:00 +0100

Authors: Chong SJ, Ooi A, Kok YO, Tan MK PMID: 22206058 [PubMed - in process] (Source: Annals of the Academy of Medicine, Singapore)

Long-lasting neuronal loss following experimental focal cerebral ischemia is not affected by combined administration of tissue plasminogen activator and hyperbaric oxygen.

Brain Research — Sat, 01 Oct 2011 00:41:12 +0100

This study aimed on neuronal loss following experimental focal cerebral ischemia, considering tissue plasminogen activator (tPA) as established treatment in stroke and hyperbaric oxygenation (HBO) as potential neuroprotective co-treatment. Wistar rats were subjected to embolic middle cerebral artery occlusion and underwent either treatment with tPA only, combined tPA+HBO, or no treatment. Neuronal impairment was assessed by Neuronal Nuclei (NeuN) staining in 4 ischemia-related areas and at 4 different time points after stroke induction (24hours, 7, 14 and 28 days). Additionally, spatial relationships between neuronal loss and gliosis were revealed by triple fluorescence staining of neurons, astrocytes and microglia, comparing the ipsi- and contra-lesional hemisphere. Analyzing the ischemic...

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Radiation Induced Temporal Lobe Necrosis in Patients with Nasopharyngeal Carcinoma: a Review of New Avenues in Its Management

Radiation Oncology — Fri, 30 Sep 2011 04:00:00 +0100

Temporal lobe necrosis (TLN) is the most debilitating late-stage complication after radiation therapy in patients with nasopharyngeal cancer (NPC). The bilateral temporal lobes are inevitably encompassed in the radiation field and are thus prone to radiation induced necrosis. The wide use of 3D conformal and intensity-modulated radiation therapy (IMRT) in the treatment of NPC has led to a dwindling incidence of TLN. Yet, it still holds great significance due to its incapacitating feature and the difficulties faced clinically and radiologically in distinguishing it from a malignancy. In this review, we highlight the evolution of different imaging modalities and therapeutic options. FDG PET, SPECT and Magnetic Spectroscopy are among the latest imaging tools that have been considered. In term...

Reduction of Apoptosis in Ischemic Retinas of Two Mouse Models Using Hyperbaric Oxygen Treatment [Biochemistry and Molecular Biology]

Investigative Ophthalmology — Thu, 29 Sep 2011 04:00:00 +0100

Conclusions. HBO treatment protects injured neuronal cells from apoptosis. Response to treatment differs molecularly after ONC or CRAO. These results should prompt clinical trials of acute ischemic retinal damage. (Source: Investigative Ophthalmology)

Effect of ascorbic acid-rich diet on in vivo-induced oxidative stress.

The British Journal of Nutrition — Fri, 16 Sep 2011 04:00:00 +0100

Authors: Alleva R, Di Donato F, Strafella E, Staffolani S, Nocchi L, Borghi B, Pignotti E, Santarelli L, Tomasetti M Abstract Using hyperbaric oxygen (HBO) therapy as an in vivo oxidation model, we investigated the effect of a diet enriched in ascorbic acid (AA) on HBO-induced oxidative stress. Volunteers (n 46) were allocated to the AA-rich diet group or the control group. Blood samples were collected at the basal time, after the 1-week diet before and immediately after the HBO treatment, and 1 week after the HBO treatment. AA level, total antioxidant status (TAS), hydroperoxides (HP), lymphocyte DNA oxidation and DNA repair capacity were assessed. The expression of genes involved in oxidative stress was evaluated in lymphocytes and the protein activity of the modulated genes was ...

Treatment of steroid refractory, Gamma Knife related radiation necrosis with bevacizumab: Case report and review of the literature

Clinical Neurology and Neurosurgery — Fri, 09 Sep 2011 04:00:00 +0100

Radiation necrosis is the most significant complication associated with Gamma Knife radiosurgery. It typically becomes manifest as a necrotic white matter lesion 3 or more months following treatment . Treatment volume and radiation dose are the two most important predictors of radiation necrosis. Once radiation necrosis has become clinically apparent treatment has historically been limited to corticosteroids. Antiplatelet agents, anticoagulants and hyperbaric oxygen have been studied but there is currently minimal high quality evidence to support their use in routine clinical practice . If the radiation necrosis fails to respond to steroid treatment therapeutic options are limited. (Source: Clinical Neurology and Neurosurgery)

Improvement of clinical outcome and cerebral perfusion in a patient of atherosclerotic cerebral infarction after repetitive hyperbaric oxygen treatment--a case report and literature review.

Undersea and Hyperbaric Medicine — Thu, 01 Sep 2011 04:00:00 +0100

Authors: Chen SY, Huang E, Wang V, Fan YM, Ho CF, Yip PK Abstract This is a case report of hyperbaric oxygen therapy (HBO2T) for ischemic stroke. HBO2T should be the potential or additional treatment (with thrombolytic therapy) for ischemic stroke according to the preclinical and clinical studies. Hereby, we present a 56-year-old Chinese man with vascular risk factors. He had an acute ischemic stroke on the left corona radiata, with right hemiparesis and dysarthria resulting from atherosclerosis. The patient could not get thrombolytic treatment because the time to ER was in excess of five hours. He experienced great improvement after the general course of HBO2T; this was evaluated with standard rating scales for stroke research and cerebral perfusion images, including brain-compute...

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Effect of hyperbaric oxygen therapy on tense repair of the peripheral nerves.

Undersea and Hyperbaric Medicine — Thu, 01 Sep 2011 04:00:00 +0100

CONCLUSIONS: In clinical practice, tension after nerve repair frequently occurs. However, neither grafting nor other current surgical methods are functionally perfect. Since primary end-to-end repair is known to be the best repair when possible, we think HBO2 allows for the use of primary repair even when nerve tension is foreseen. PMID: 22013762 [PubMed - in process] (Source: Undersea and Hyperbaric Medicine)

Hyperbaric oxygen therapy and promoting neurological recovery following nerve trauma.

Undersea and Hyperbaric Medicine — Thu, 01 Sep 2011 04:00:00 +0100

Authors: Nazario J, Kuffler DP Abstract There is a constant search for new techniques that induce more extensive and rapid wound healing. Hyperbaric oxygen therapy (HBO2T) involves placing a patient in a sealed chamber and elevating its pressure several-fold above ambient air pressure while the patient breathes 100% oxygen. HBO2T induces a number of physiological actions, and which wounds are selected for HBO2T depends on the specific actions of HBO2T relative to the wound's healing requirements. Although nerve traumas are not yet indicated for HBO2T, there are many animal and clinical examples showing the benefits of HBO2T in inducing neurological recovery following nerve trauma. This review examines the general mechanisms required to induce wound healing and the actions of HBO2T ...

Combined effects of intravenous perfluorocarbon emulsion and oxygen breathing on decompression-induced spinal cord injury in rats.

Undersea and Hyperbaric Medicine — Thu, 01 Sep 2011 04:00:00 +0100

Authors: Zhang RJ, Liu K, Kang ZM, Fan DF, Ni XX, Liu Y, Lian QL, Sun XJ, Tao HY, Xu WG Abstract The spinal cord is one of the most commonly affected sites in decompression sickness (DCS). Alternative methods have long been sought to protect against DCS spinal cord dysfunction, especially when hyperbaric treatment is unavailable. Use of perfluorocarbon (PFC) emulsion with or without oxygen breathing has shown survival benefits in DCS animal models. The effectiveness of intravenous PFC emulsion with oxygen breathing on spinal cord function was studied. Somatosensory-evoked potentials (SSEPs) and histologic examination were chosen to serve as measures. After fast decompression (203 kPa/minute) from 709 kPa (for 60 minutes), male Sprague-Dawley rats randomly received: 1) air and salin...

Treatment of acute stroke with hyperbaric oxygen: time window for efficacy.

Undersea and Hyperbaric Medicine — Thu, 01 Sep 2011 04:00:00 +0100

We examined patients who received HBO2 treatment within seven hours post-stroke. An exploratory logistic regression analysis examining the influence of time post-stroke, time in chamber and dose of HBO2, range 2.02 atmospheres absolute (ATA) to 3.04 ATA, was conducted. Only time post-stroke was a significant influence for recovery, with each passing hour decreasing the chance of at least partial transient recovery by 62% - odds ratio: 0.38 (95% CI: 0.15 -0.95), p = 0.039. In the one- to five-hour group of 13 patients, nine (41% of 22) had recovery or recovery with relapse. This represented 69% (+/- 25% SE) of this time frame. Only two of the nine had permanent recovery. Past six hours poststroke, only one patient (11% +/- 21% SE) had partial recovery with relapse. The other eight past six ...

Hyperbaric oxygen for neurologic indications--action plan for multicenter trials in: stroke, traumatic brain injury, radiation encephalopathy & status migrainosus.

Undersea and Hyperbaric Medicine — Thu, 01 Sep 2011 04:00:00 +0100

Authors: Helms A, Evans AW, Chu J, Sahgal A, Ostrowski R, Sosiak T, Wolf G, Gillett J, Whelan H Abstract The 2008 Toronto Hyperbaric Medicine Symposium was convened to discuss research into neurologic indications for hyperbaric oxygen therapy (HBO2T). Four topics were particularly addressed: acute ischemic stroke; acute traumatic brain injury; brain radiation necrosis; and status migrainosus. Four multicenter trials were designed and proposed to evaluate the efficacy of HBO2T for these indications and are presented here in addition to brief reviews of the rationale behind each. PMID: 22013758 [PubMed - in process] (Source: Undersea and Hyperbaric Medicine)

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Neurologic applications of hyperbaric oxygen: a sad, slow story of smoke and fire.

Undersea and Hyperbaric Medicine — Thu, 01 Sep 2011 04:00:00 +0100

Authors: Mychaskiw G PMID: 22013757 [PubMed - in process] (Source: Undersea and Hyperbaric Medicine)

Effect of hyperbaric oxygen treatment on myogenic transcriptional factors in regenerating rat masseter muscle.

Collegium Antropologicum — Thu, 01 Sep 2011 04:00:00 +0100

Authors: Bajek S, Nikolić M, Soić-Vranić T, Arbanas J, Bajek G Abstract Hyperbaric oxygen (HBO) treatment was shown to be beneficial as an additional treatment for ischemic muscles in crush injuries and ischemia-reperfusion injuries. The purpose of this study was to assess the influence of hyperbaric oxygen treatment on transcriptional myogenic factors during muscle regeneration. Those factors (MyoD, myf5, myogenin, mrf4) are essential for determination and differentiation of skeletal muscle tissue and together with several other factors control gene expression during myogenesis. The process of regeneration in rat masseter muscle was provoked with injection of local anesthetic bupivacaine hydrochloride. Following injection, the animals were treated once daily in hyperbaric chamb...

Comparison of intravesical hyaluronic acid instillation and hyperbaric oxygen in the treatment of radiation‐induced hemorrhagic cystitis

BJU International — Wed, 31 Aug 2011 23:00:00 +0100

CONCLUSIONS• Intravesical instillation of HA was as effective in treating radiation‐induced HC as HBO.• It is well tolerated and resulted in a sustained decrease of bladder bleeding, pelvic pain and frequency of voiding for at least 12 months. (Source: BJU International)

Effects of hyperbaric oxygen treatment on horses with experimentally induced endotoxemia.

American Journal of Veterinary Research — Wed, 31 Aug 2011 23:00:00 +0100

Conclusions and Clinical Relevance-The protective effect of HBOT was minimal, and results did not support its use as a treatment for horses prior to development of endotoxemia. PMID: 21879987 [PubMed - in process] (Source: American Journal of Veterinary Research)

Intractable Bladder Hemorrhage: Providing a Treatment Algorithm for a Complex Clinical Problem

Current Bladder Dysfunction Reports — Wed, 31 Aug 2011 15:55:14 +0100

Abstract Information about the frequency, intensity, prevention, treatment, and management of bladder hemorrhages, especially in patients with advanced bladder carcinoma, is lacking or scarce. The main treatment options are classified as intravesical treatment attempts using several chemical agents, placement of intrabladder compression balloon, hyperbaric oxygen treatment, transarterial embolization, or surgery. In view of the differences between patients with regard to the causes of bleeding, immediate treatment options, availability of the treatment modalities in each institution, life expectancy of the patient, and accompanying comorbidities, the management of each patient should be arranged individually. Nevertheless, based on the current literature, a treatment algor...

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Hyperbaric Oxygen Therapy for Traumatic Brain Injury: Still an Enigma

Archives of Physical Medicine and Rehabilitation — Mon, 29 Aug 2011 21:23:26 +0100

Abstract: Masel BE. Hyperbaric oxygen therapy for traumatic brain injury: still an enigma.With their article on the use of HBOT for post TBI dysautonomia, Lv and colleagues discuss a novel use for this form of treatment. Although HBOT has been a part of our TBI treatment armamentarium for many years, its use remains a very controversial issue. In this commentary, the science and research studies behind HBOT for TBI are reviewed, hopefully leaving the reader with an adequate knowledge base to answer a patient or family's inquiries as to the usefulness of HBOT for TBI. (Source: Archives of Physical Medicine and Rehabilitation)

Extremely rare but potential complication of diffuse brain edema due to air embolism during lung segmentectomy with selected segmental inflation technique by syringe needle during video-assisted thoracoscopic surgery

The Journal of Thoracic and Cardiovascular Surgery — Mon, 29 Aug 2011 04:00:00 +0100

A 65-year-old man was diagnosed with right lung cancer in the upper lobe and S8 segment. To avoid right pneumonectomy, he underwent right upper lobectomy and S8 segmentectomy by video-assisted thoracoscopic surgery. During segmentectomy, the A8 was ligated first, and then B8 was resected using an automatic stapler. An 18-gauge needle was inserted in the distal B8 bronchus without any blood regurgitation. After removing the inner needle, an air tube of a Bolheal Spray Set (The Chemo-Sero-Therapeutic Research Institute, Kumamoto, Japan) with a filter attached was connected to the outer dwelling sheath, and air was blown into the tube. Because the air was not confirmed in the target area, which usually inflates, we stopped blowing air and removed the punctured in-dwelling needle. Immediately...

Multi-intervention Management of Calciphylaxis: A Report of 7 Cases

American Journal of Kidney Diseases — Mon, 29 Aug 2011 04:00:00 +0100

We report a case series of 7 patients at a single institution in whom a systematic multi-interventional treatment strategy was implemented, consisting of trigger-agent cessation (calcium-based phosphate binders, alphacalcidol, and warfarin), wound management, and antibiotic therapy, supplemented by intensified hemodialysis (4 hours daily for 7 days followed by 5-6 times weekly), intravenous sodium thiosulfate (12.5-25 g intravenously 3 times a week), and attempted oxygen therapy (given through a face mask or hyperbaric chamber as tolerated by patient circumstance). Treatments selected were based on literature review, consensus discussion, and attempts to address the physiologic disturbances that underlie the condition. All 7 patients identified with biopsy-proven calcific uremic arteriolop...

Diabetes: foot ulcers and amputations

Clinical Evidence — Fri, 26 Aug 2011 23:00:00 +0100

New evidence; conclusion confirmed for: Education New evidence added. Categorisation unchanged (Unknown effectiveness) as there remains insufficient good-quality evidence to assess the effects of education on diabetic foot ulcers and amputations. Pressure off-loading (total-contact or non-removable cast) New evidence added. Categorisation unchanged (Likely to be beneficial). Systemic hyperbaric oxygen (infected ulcers) New evidence added. Categorisation unchanged (Likely to be beneficial). Topical growth factors New evidence added. Categorisation unchanged (Likely to be beneficial). Debridement or wound dressings One systematic review updated, new evid...

Preconditioning With Repeated Hyperbaric Oxygen Induces Myocardial and Cerebral Protection in Patients Undergoing Coronary Artery Bypass Graft Surgery: A Prospective, Randomized, Controlled Clinical Trial

Journal of Cardiothoracic and Vascular Anesthesia — Fri, 26 Aug 2011 04:00:00 +0100

Conclusions: Preconditioning with HBO resulted in both cerebral and cardiac protective effects as determined by biochemical markers of neuronal and myocardial injury and clinical outcomes in patients undergoing on-pump coronary artery bypass graft surgery. No protective effects were noted in off-pump coronary artery bypass graft surgery. (Source: Journal of Cardiothoracic and Vascular Anesthesia)

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Hyperbaric oxygen therapy for acute coronary syndrome.

Cochrane Database of Systematic Reviews — Sat, 20 Aug 2011 17:00:05 +0100

CONCLUSIONS: For people with ACS, there is some evidence from small trials to suggest that HBOT is associated with a reduction in the risk of death, the volume of damaged muscle, the risk of MACE and time to relief from ischaemic pain. In view of the modest number of patients, methodological shortcomings and poor reporting, this result should be interpreted cautiously, and an appropriately powered trial of high methodological rigour is justified to define those patients (if any) who can be expected to derive most benefit from HBOT. The routine application of HBOT to these patients cannot be justified from this review. PMID: 21833950 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)

Limited Evidence to Demonstrate that the Use of Hyperbaric Oxygen (HBO) Therapy Reduces the Incidence of Osteoradionecrosis in Irradiated Patients Requiring Tooth Extraction

The Journal of Evidence-Based Dental Practice — Sat, 20 Aug 2011 15:29:05 +0100

Article Title and Bibliographic Information: Efficacy of pre- and postirradiation hyperbaric oxygen therapy in the prevention of postextraction osteoradionecrosis: a systematic review.Fritz GW, Gunsolley JC, Abubaker O, Daniel M, Laskin DM.J Oral Maxillofac Surg 2010;68(11):2653-60. Epub 2010 Aug 19.Reviewer: Sung-Kiang Chuang, DMD, MD, DMScPurpose/Question: To evaluate the best-available evidence in the literature regarding the use of HBO in the prevention of osteoradionecrosis (ORN) after tooth extraction in irradiated patients.Source of Funding: Information not availableType of Study/Design: Systematic reviewLevel of Evidence: Level 2: Limited-quality patient-oriented evidenceStrength of Recommendation Grade: Grade B: Inconsistent or limited-quality, patient-oriented evidence (Source:...

Brief Report: Hyperbaric Oxygen Therapy (HBOT) in Children with Autism Spectrum Disorder: A Clinical Trial.

Journal of Autism and Developmental Disorders — Thu, 04 Aug 2011 23:00:00 +0100

Authors: Bent S, Bertoglio K, Ashwood P, Nemeth E, Hendren RL We sought to determine whether HBOT leads to parental reported behavioral changes and alterations in cytokines in children with ASD. Ten children completed 80 sessions of HBOT and all improved by 2 points on the clinician-rated CGI-I scale (much improved) as well as several parent-completed measures of behavior. The lack of a control group limits the ability to determine if improvements were related to HBOT. Enrolled children did not exhibit abnormal cytokine levels at baseline and no significant changes in mean cytokine levels were observed. Although this study was limited by the small sample size and by the variable nature of cytokines, we found no evidence that HBOT affects cytokine levels or that cytokine levels were ass...

Successful Treatment of Post Circumcision Glanular Ischemia-Necrosis with Hyperbaric Oxygen and Intravenous Pentoxifylline.

Actas Urologicas Espanolas — Thu, 04 Aug 2011 23:00:00 +0100

Authors: Elemen L, Topçu K, Gürcan NI, Akay A PMID: 21821318 [PubMed - as supplied by publisher] (Source: Actas Urologicas Espanolas)

Hyperbaric oxygen therapy in a mouse model of implant‐associated osteomyelitis

Journal of Orthopaedic Research — Tue, 02 Aug 2011 23:00:00 +0100

AbstractImplant associated osteomyelitis (OM) is difficult to treat with antibiotics, and outcomes remain poor. Some reports suggest that hyperbaric oxygen treatment is a safe and effective means of treating OM. We tested this hypothesis in a murine model. Clinical isolates of methicillin‐resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa, and Klebsiella pneumoniae were used. The mice were infected with each of the three pathogens, treated with 100% oxygen at high pressure, hyperbaric oxygen (HBO), and monitored for the ability of HBO to prevent and/or clear the OM infection. Assessments included bacterial burden of the tibias and lesion scores, as well as receptor activator of NF‐κB ligand (RANKL) and myeloperoxidase (MPO) concentrations. HBO resulted in more severe lesio...

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Increased Expression of Hypoxia-inducible Factor-1α and Vascular Endothelial Growth Factor Associated With Glomerulation Formation in Patients With Interstitial Cystitis

Urology — Tue, 02 Aug 2011 04:00:00 +0100

Conclusion: Our findings identified increased expression of HIF-1α in bladder tissue and overexpression of VEGF in umbrella cells from patients with IC. These events may be associated with glomerulation formation during hydrodistention in IC bladders. Thus, these molecular findings could offer the therapeutic mechanism for hyperbaric oxygenation application to patients with IC. (Source: Urology)

Oxygen therapy for cerebral malaria

Travel Medicine and Infectious Disease — Tue, 02 Aug 2011 04:00:00 +0100

This article examines the current understanding of CM, and the possible benefits provided by HBO therapy. (Source: Travel Medicine and Infectious Disease)

Re: Comparison of therapeutic results in sudden sensorineural hearing loss with/without additional hyperbaric oxygen therapy: a retrospective review of 465 audiologically controlled cases

Clinical Otolaryngology — Sun, 31 Jul 2011 23:00:00 +0100

(Source: Clinical Otolaryngology)

Hyperbaric oxygen for radiation injury: is it indicated?

Current Oncology — Mon, 25 Jul 2011 14:00:32 +0100

(Source: Current Oncology)

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Hyperbaric Oxygen Tested For Aggressive Brain Cancer

Health News from Medical News Today — Sat, 23 Jul 2011 07:00:00 +0100

In a unique study, researchers at The Long Island Brain Tumor Center at Neurological Surgery, P.C. are examining whether hyperbaric oxygen therapy breathing pure oxygen while in a pressurized chamber may prove a useful addition to the current standard of care for patients newly diagnosed with glioblastoma, an aggressive brain cancer. The Phase II study is currently enrolling participants, and is being conducted at Neurological Surgery, P.C. offices in Nassau and Suffolk Counties, New York, as well as at Winthrop University Hospital, Mineola, NY... (Source: Health News from Medical News Today)

Hyperbaric oxygen therapy for late radiation tissue injury in gynecologic malignancies

Current Oncology — Wed, 20 Jul 2011 13:56:16 +0100

ConclusionsBased on the evidence and expert consensus opinion,HBO2 is likely effective for late radiation tissue injury of the pelvis, with demonstrated efficacy specifically for radiation damage to the anus and rectum;the main indication for HBO2 therapy in gynecologic oncology is in the management of otherwise refractory chronic radiation injury;HBO2 may provide symptomatic benefit in certain clinical settings (for example, cystitis, soft-tissue necrosis, and osteonecrosis); andHBO2 may reduce the complications of gynecologic surgery in patients undergoing surgical removal of necrosis. (Source: Current Oncology)

Evaluation and Comparison of the Effects of Hyperbaric Oxygen and Ozonized Oxygen as Adjuvant Treatments in an Experimental Osteomyelitis Model

Journal of Surgical Research — Mon, 18 Jul 2011 04:00:00 +0100

Conclusions: O3 was as effective as HBO in decreasing oxidative parameters and inflammatory cytokines. Rats in the VO and VOHB groups gained more weight than did the other groups. Bacteria counts were significantly decreased in group VOHB compared with the other groups. Histopathologic scores in group VO were significantly decreased compared with the other groups. (Source: Journal of Surgical Research)

Value of hyperbaric oxygen in bacterial and fungal malignant external otitis treatment

The Aspergillus Website - articles — Fri, 15 Jul 2011 23:48:49 +0100

Narozny W, Kuczkowski J, Stankiewicz C, Kot J, Mikaszewski B, Przewozny T (Source: The Aspergillus Website - articles)

Fungal malignant otitis externa treated with hyperbaric oxygen

The Aspergillus Website - articles — Fri, 15 Jul 2011 22:49:38 +0100

Ling SS, Sader C (Source: The Aspergillus Website - articles)

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Hyperbaric oxygen therapy in diabetic patients - comments on the paper by Karadurmus et al.

Endokrynologia Polska — Tue, 12 Jul 2011 13:00:02 +0100

Authors: Uzun G, Mutluoglu M, Uz O PMID: 21717415 [PubMed - in process] (Source: Endokrynologia Polska)

Hyperbaric oxygen preconditioning: what remains between hypoxia and hyperoxia?

Clinical and Experimental Pharmacology and Physiology — Mon, 11 Jul 2011 23:00:00 +0100

Authors: Mik EG PMID: 21749437 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)

Molecular changes in diabetic foot ulcers

Diabetes Research and Clinical Practice — Mon, 11 Jul 2011 04:00:00 +0100

This study investigated the molecular changes of extracorporeal shockwave therapy (ESWT) and hyperbaric oxygen therapy (HBOT) in chronic diabetic foot ulcers.Methods: A cohort study consisted of 39 patients (44 ulcers) in the ESWT group and 38 patients (40 ulcers) in the HBOT group with similar demographic characteristics. The ESWT group received shockwave therapy twice per week for total six treatments. The HBOT group received hyperbaric oxygen therapy daily for total 20 treatments. Biopsy was performed from the periphery of the ulcer before and after treatment. The specimens were immuno-stained, and the positive immuno-activities of vWF, VEGF, eNOS, PCNA, EGF and TUNEL expressions were examined and quantified microscopically.Results: Significant increases in vWF, VEGF, eNOS, PCNA and EGF...

Hyperbaric oxygen-A new horizon in treating cyclophosphamide-induced hemorrhagic cystitis

Indian Journal of Urology — Thu, 07 Jul 2011 23:00:00 +0100

S Ajith Kumar, P Prasanth, KK Tripathi, PC GhoshIndian Journal of Urology 2011 27(2):271-273Hemorrhagic cystitis consists of acute or insidious diffuse bleeding from the bladder mucosa. It can be caused by radiation, drugs, autoimmune diseases, viral and bacterial infections, etc. Hemorrhagic cystitis is a well-recognized complication of cyclophosphamide therapy and it can be potentially fatal. We discuss two cases of cyclophosphamide-induced hemorrhagic cystitis where outcome of conventional management was not satisfactory and a novel therapy using hyperbaric oxygen was used. Hyperbaric oxygen therapy (HBOT) reduces inflammation, stimulates neoangiogenesis, maintains tissue oxygenation and heals tissue hypoxia and radio necrosis. Patients received 100% oxygen in a hyperbaric chambe...

Preconditioning with Hyperbaric Oxygen Induces Tolerance Against Renal Ischemia-Reperfusion Injury Via Increased Expression of Heme Oxygenase-1

Journal of Surgical Research — Thu, 07 Jul 2011 04:00:00 +0100

Conclusions: Hyperbaric oxygen preconditioning (HBO-PC) can protect renal I/R injury against oxidative stress, and the up-regulation of HO-1 expression plays an essential role in HBO induced preconditioning effect. (Source: Journal of Surgical Research)

1H-magnetic resonance spectroscopy indicates damage to cerebral white matter in the subacute phase after CO poisoning

Journal of Neurology, Neurosurgery and Psychiatry — Wed, 06 Jul 2011 23:00:00 +0100

Conclusions These results suggest that the Cho/Cr ratio in the subacute phase after CO intoxication represents early demyelination in the centrum semiovale, and can predict chronic neurological symptoms. (Source: Journal of Neurology, Neurosurgery and Psychiatry)

Hyperbaric oxygen treatment to eliminate a large venous air embolism: a case study.

Undersea and Hyperbaric Medicine — Thu, 30 Jun 2011 23:00:00 +0100

Authors: Torres Martínez FJ, Kuffler DP Abstract Gas embolism, the entry of gas into vascular structures, can result in serious morbidity and death. It is an inadvertent clinical problem, but it also occurs in non-clinical environments. Gas embolisms result from procedures performed in almost all clinical specialties, thus making it a problem about which all clinicians should be aware. In most cases, gas embolism is air embolism, although it can result from the introduction of gases such as carbon dioxide, nitrous oxide and nitrogen. Gas embolism takes two forms, venous and arterial, distinguished by the mechanism of gas entry and the site where the emboli ultimately lodge. Techniques used to eliminate embolisms including administration of 100% oxygen, placing the patient in later...

The history of hyperbaric oxygen therapy and kidney transplant surgery.

Undersea and Hyperbaric Medicine — Thu, 30 Jun 2011 23:00:00 +0100

Authors: Malazai AJ, Worku DG, McGee J, Van Meter K, Slakey DP PMID: 21877553 [PubMed - in process] (Source: Undersea and Hyperbaric Medicine)

Hyperbaric oxygen therapy or hydroxycobalamin attenuates surges in brain interstitial lactate and glucose; and hyperbaric oxygen improves respiratory status in cyanide-intoxicated rats.

Undersea and Hyperbaric Medicine — Thu, 30 Jun 2011 23:00:00 +0100

In conclusion, CN intoxication in anesthetized rats produces specific uncoupling of cerebral oxidative metabolism resulting in interstitial lactate and glucose surges that may be ameliorated by treatment with either hydroxycobalamin or HBO2. PMID: 21877551 [PubMed - in process] (Source: Undersea and Hyperbaric Medicine)

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Hydroxycobalamin, hyperbaric oxygen and cyanide poisoning.

Undersea and Hyperbaric Medicine — Thu, 30 Jun 2011 23:00:00 +0100

Authors: Desola J PMID: 21877549 [PubMed - in process] (Source: Undersea and Hyperbaric Medicine)

Heme oxygenase 1 may mediate the protective effects of hyperbaric oxygen preconditioning against hepatic ischemia-reperfusion injury in rats.

Clinical and Experimental Pharmacology and Physiology — Mon, 27 Jun 2011 23:00:00 +0100

In conclusion, HBO preconditioning can protect the liver against I/R injury and it appears that this effect may be mediated by the induction of HO-1. PMID: 21711378 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)

Influence of Hyperbaric Oxygen Therapy on Central Corneal Thickness

Ophthalmic Research — Mon, 20 Jun 2011 23:00:00 +0100

Ophthalmic Res 2012;47:19–22 (DOI:10.1159/000327703) (Source: Ophthalmic Research)

[Respiratory tract burn injuries.]

Pneumonologia i Alergologia Polska — Fri, 17 Jun 2011 13:15:08 +0100

Authors: Wróblewski P, Knefel G, Trzaska M, Kawecki M, Nowak M, Kozielski J Respiratory tract burns are one of the most serious injuries of human organism. They often accompany severe skin burns, increasing morbidity and mortality. Pathologic events happening in the lungs in the course of inhalation injury consist of: edema and necrosis of bronchial mucosa, increase of bronchial blood flow and vascular permeability, recruitment of inflammatory mediators, and obturation of bronchial tract with the casts composed of mucus, tissue debris, neutrophils and fibrin. The above mentioned processes lead to progressive disturbances of pulmonary gas exchange and tissue hypoxia. Introduction of standardized bronchoscopic procedures resulted in the possibility of early diagnosis and treatment of in...

Hyperbaric oxygen therapy for carbon monoxide poisoning

Intensive Care Medicine — Sat, 11 Jun 2011 06:38:05 +0100

Content Type Journal ArticlePages 1-2DOI 10.1007/s00134-011-2262-9Authors G. Garrabou, Mitochondrial Research Laboratory, Muscle Research Unit, IDIBAPS, Faculty of Medicine-University of Barcelona, Internal Medicine Department-Hospital Clinic of Barcelona, Barcelona, SpainJ. M. Inoriza, Hyperbaric Medicine Unit, Hospital of Palamós, Serveis de Salut Integrats Baix Empordà, Girona, SpainC. Morén, Mitochondrial Research Laboratory, Muscle Research Unit, IDIBAPS, Faculty of Medicine-University of Barcelona, Internal Medicine Department-Hospital Clinic of Barcelona, Barcelona, SpainG. Oliu, Hyperbaric Medicine Unit, Hospital of Palamós, Serveis de Salut Integrats Baix Empordà, Girona, SpainÒ. Miró, Mitochondrial Research Laboratory, Muscle Research Unit, IDIBAPS, Faculty of Medicine...

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The role of nitric oxide in cellular response to hyperbaric conditions

European Journal of Applied Physiology — Wed, 08 Jun 2011 15:45:33 +0100

In conclusion, the data suggested a key role for NO in the beneficial HBO action, depending on its concentration, which fluctuated with the time of HBO exposure and the activation of oxidant–antioxidant (REDOX) mechanisms, regardless of cell type. Content Type Journal ArticlePages 1-11DOI 10.1007/s00421-011-2027-8Authors Kyriaki Venetsanou, Athens University Faculty of Nursing, Hyperbaric Oxygen Therapy Unit and Research Unit at ‘KAT’ General Hospital, Nikis 2, Kifissia, 14561 Athens, GreeceGeorge Fildissis, Athens University Faculty of Nursing, Hyperbaric Oxygen Therapy Unit and Research Unit at ‘KAT’ General Hospital, Nikis 2, Kifissia, 14561 Athens, GreeceRea Tokta, Athens University Faculty of Nursing, Hyperbaric Oxygen Therapy Unit and Research Unit at ‘KAT’ Gene...

The effects of zoledronic acid and hyperbaric oxygen on posterior lumbar fusion in a rabbit model.

The Journal of Bone and Joint Surgery. British volume — Tue, 31 May 2011 23:00:00 +0100

Authors: Yalçin N, Oztürk A, Ozkan Y, Celimli N, Ozocak E, Erdogan A, Sahin N, Ilgezdi S We studied the effects of hyperbaric oxygen (HBO) and zoledronic acid (ZA) on posterior lumbar fusion using a validated animal model. A total of 40 New Zealand white rabbits underwent posterior lumbar fusion at L5-6 with autogenous iliac bone grafting. They were divided randomly into four groups as follows: group 1, control; group 2, HBO (2.4 atm for two hours daily); group 3, local ZA (20 μg of ZA mixed with bone graft); and group 4, combined HBO and local ZA. All the animals were killed six weeks after surgery and the fusion segments were subjected to radiological analysis, manual palpation, biomechanical testing and histological examination. Five rabbits died within two weeks of operation. Th...

Oral rehabilitation with dental implants after cancer treatment

Australian Dental Journal — Tue, 31 May 2011 23:00:00 +0100

Conclusions: Dental implants provide an important role in the oral rehabilitation of oral cancer patients. There may be an increased risk of implant failure in free flap bone that has been irradiated. (Source: Australian Dental Journal)

The excitement of multiple noradrenergic cell groups in the rat brain related to hyperbaric oxygen seizure.

Acta Med Okayama — Tue, 31 May 2011 23:00:00 +0100

In this study, we defined the activation of noradrenergic cells during HBO exposure by c-fos immunohistochemistry. Electroencephalogram electrodes were pre-implanted in all animals under general anesthesia. In HBO seizure animals, HBO was induced with 5 atm of 100% oxygen until manifestation of general tonic convulsion. HBO non-seizure animals were exposed to 25 min of HBO. Control animals were put in the chamber for 120 min without pressurization. All animals were processed for c-fos immunohistochemical staining. All animals in the HBO seizure group showed electrical discharge on EEG. In the immunohistochemistry, c-fos was increased in the A1, A2 and A6 cells of the HBO seizure group, and in the A2 and A6 cells of the HBO non-seizure group, yet was extremely low in all three cell types in...

Effect of exposure to hyperbaric oxygen on diabetes‐induced cataracts in mice

Journal of Diabetes — Tue, 31 May 2011 23:00:00 +0100

Conclusions: Hyperbaric exposure at 1.25 ATA with 36% oxygen delays cataract development and progression in mice with type 2 diabetes. (Source: Journal of Diabetes)

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Comment on: Lipsky and Berendt. Hyperbaric Oxygen Therapy for Diabetic Foot Wounds: Has Hope Hurdled Hype? Diabetes Care 2010;33:1143-1145.

Diabetes Care — Mon, 30 May 2011 05:01:07 +0100

Authors: van der Staal SR, Ubbink DT, Lubbers MJ PMID: 21617103 [PubMed - in process] (Source: Diabetes Care)

Response to Comment on: Lipsky and Berendt. Hyperbaric Oxygen Therapy for Diabetic Foot Wounds: Has Hope Hurdled Hype? Diabetes Care 2010;33:1143-1145.

Diabetes Care — Mon, 30 May 2011 05:01:01 +0100

Authors: Lipsky BA PMID: 21617104 [PubMed - in process] (Source: Diabetes Care)

Response to comment on: Londahl et al. Hyperbaric Oxygen Therapy Facilitates Healing of Chronic Foot Ulcers in Patients With Diabetes. Diabetes Care 2010;33:998-1003.

Diabetes Care — Mon, 30 May 2011 05:00:48 +0100

Authors: Löndahl M, Katzman P, Nilsson A, Hammarlund C PMID: 21617105 [PubMed - in process] (Source: Diabetes Care)

Hyperbaric Oxygen Therapy in the Management of Paroxysmal Sympathetic Hyperactivity After Severe Traumatic Brain Injury: A Report of 6 Cases

Archives of Physical Medicine and Rehabilitation — Thu, 26 May 2011 23:00:00 +0100

This report presents 6 cases of PSH after extremely severe traumatic brain injury in which hyperbaric oxygen therapy (HBOT) controlled paroxysmal autonomic changes and posturing in the early subacute phase after limited success with conventional medication regimens. Thus, HBOT may present an option for the management of PSH in addition to pharmacologic therapy. Potential mechanisms for these effects are discussed. (Source: Archives of Physical Medicine and Rehabilitation)

Hyperbaric oxygen therapy for painful bladder syndrome/interstitial cystitis resistant to conventional treatments: long-term results of a case series in Japan

BMC Urology - Latest articles — Mon, 23 May 2011 23:00:00 +0100

Background: There is no confirmed strategy for treating painful bladder syndrome/interstitial cystitis (PBS/IC) with unclear etiology. Therefore, a pilot study was carried out to evaluate the efficacy and safety of hyperbaric oxygen (HBO) therapy in treatment-resistant PBS/IC patients. Methods: HBO treatment (2.0 ATA for 60 minutes/day x 5 days/week for 2 or 4 weeks) was performed on 11 patients with severe symptoms that had not been improved by previous therapy regimens between December 2004 and July 2009. Results: Seven of the 11 patients demonstrated persistent improvement in symptoms during the 12 months after HBO treatment. These responders demonstrated a decrease in the pelvic pain scale and urgency scale from 7.7+/-1.0 and, 6.6+/-0.9 to 3.4+/-2.5 and, 4.3+/-2.4 at 12 months, respect...

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Hyperbaric Oxygenation Therapy Alleviates Chronic Constrictive Injury-Induced Neuropathic Pain and Reduces Tumor Necrosis Factor-Alpha Production.

Anesthesia and Analgesia — Wed, 18 May 2011 23:00:00 +0100

Conclusion: These data show that HBOT alleviates CCI-induced neuropathic pain and inhibits endoneuronal TNF-α production, but not IL-1β in CCI-induced neuropathic pain. Reduced TNF-α production may, at least in part, contribute to the beneficial effect of HBOT. PMID: 21596875 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)

Hyperbaric Oxygen Chambers: Is Oxygen Therapy Useful?

Dr. Weil Q and A — Tue, 17 May 2011 10:09:57 +0100

What are the benefits and risks of using hyperbaric oxygen chambers? I understand that spending time in one provides many health benefits. (Source: Dr. Weil Q and A)

Mandibular osteomyelitis in children mimicking juvenile recurrent parotitis

International Journal of Pediatric Otorhinolaryngology — Thu, 12 May 2011 18:18:13 +0100

Conclusions: Juvenile parotitis is in most cases a clinical diagnosis, and treatment is symptomatic. In contrast, mandibular osteomyelitis is a severe disease requiring lengthy treatment. Because symptoms of these two entities may mimic each other, unclear cases require MRI. (Source: International Journal of Pediatric Otorhinolaryngology)

Hyperbaric oxygen therapy reduces the toll-like receptor signaling pathway in multiple organ failures

Intensive Care Medicine — Thu, 12 May 2011 16:42:10 +0100

Conclusions Taken together, these results suggest that, by interfering with the TLR pathway, HBO treatment may exert a protective effect against tissue injury caused by zymosan-induced generalized inflammation. Content Type Journal ArticlePages 1-10DOI 10.1007/s00134-011-2241-1Authors Barbara Rinaldi, Department of Experimental Medicine, Excellence Center for Cardiovascular Diseases, Second University of Naples, via De Crecchio 7, 80138 Naples, ItalySalvatore Cuzzocrea, IRCCS Centro Neurolesi “Bonino-Pulejo”, Messina, ItalyMaria Donniacuo, Department of Experimental Medicine, Excellence Center for Cardiovascular Diseases, Second University of Naples, via De Crecchio 7, 80138 Naples, ItalyAnnalisa Capuano, Department of Experimental Medicine, Excellence Center for...

Effect of hyperbaric oxygen therapy in rats with subtotal splenectomy preserving the inferior pole.

Acta Cirurgica Brasileira — Thu, 05 May 2011 22:01:21 +0100

Authors: Paulo MS, Paulo IC, Nunes TA, Silva AL, Cintra LC, Paulo DN To evaluate the effect of hyperbaric oxygen therapy on the survival and weight of rats submitted to subtotal splenectomy and on the viability and growth of the inferior pole. PMID: 21537516 [PubMed - in process] (Source: Acta Cirurgica Brasileira)

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What is the Role of Hyperbaric Oxygen in the Management of Diabetic Foot Disease?

Current Diabetes Reports — Mon, 02 May 2011 05:43:12 +0100

Abstract Systemic hyperbaric oxygen (HBO) is accomplished when a patient is breathing 100% oxygen in an environment with increased barometric pressure. A typical HBO treatment protocol of diabetic foot ulcer involves 20 to 40 sessions. Treatment is usually given as daily 90- to 120-minute HBO sessions at pressures between 2.0 and 2.5 absolute atmospheres. The wide use of HBO as treatment of diabetic foot ulcers over the past decades has been founded on weak scientific ground (ie, few and small prospective studies with methodologic limitations on top of case series). However, the consistency in positive outcome in these trials evaluating HBO on ulcer healing is noteworthy because these findings are in concert with data from in vitro and physiologic studies supporting the th...

Systemic arterial air embolism after percutaneous lung biopsy

Clinical Radiology — Sun, 01 May 2011 23:00:00 +0100

We present a comprehensive review of iatrogenic air embolism post-lung biopsy, a complication that is often suboptimally managed. This review was inspired by our own institutional experience and we use this to demonstrate that excellent outcomes from this complication can be seen with prompt treatment using hyperbaric oxygen chamber therapy, after initial patient stabilization has been achieved. Pathophysiology, clinical features, and risk factors are reviewed and misconceptions regards venous versus arterial air embolism are examined. An algorithm is provided for radiologists to ensure suspected patients are appropriately managed with more favourable outcomes. (Source: Clinical Radiology)

Effects of hyperbaric oxygenation on oxidative stress in acute transient focal cerebral ischemic rats

European Journal of Applied Physiology — Sat, 30 Apr 2011 23:37:03 +0100

Abstract The aim of this study was to investigate the effects of hyperbaric oxygenation (HBO) after brain ischemia. Middle cerebral artery occlusion (MCAO) procedure was used to induce the brain ischemia. Rats were assigned to control or HBO group after brain ischemia. In order to examine the role of glutathione after HBO treatment, another group of brain ischemic rats were included to receive the glutathione synthesis inhibitor and HBO treatment. HBO was administered at a pressure of 3 atmospheres absolute for 1 h with 100% oxygen, starting at 3 h post brain ischemia in HBO groups. Animals in control group were placed in their home cage and exposed to normobaric room air. The infarct volume (IV), activation of astrocyte, and level of total glutathione and lipid ...

Case reports: hyperbaric oxygen therapy for the treatment of cerebral air embolism.

Undersea and Hyperbaric Medicine — Sat, 30 Apr 2011 23:00:00 +0100

We report our experience with iatrogenic cerebral air embolism and hyperbaric oxygen treatment. PMID: 21721354 [PubMed - indexed for MEDLINE] (Source: Undersea and Hyperbaric Medicine)

Research report: the effects of hyperbaric oxygen preconditioning on myocardial biomarkers of cardioprotection in patients having coronary artery bypass graft surgery.

Undersea and Hyperbaric Medicine — Sat, 30 Apr 2011 23:00:00 +0100

In this study, no significant differences were observed between the groups with respect to the quantity of myocardial eNOS and HSP72. However, in the HBO2 Group, following ischemia and reperfusion, the quantities of myocardial eNOS and HSP72 were increased. This suggests that HBO2 preconditioning in this group of patients may be capable of inducing endogenous cardioprotection following ischemic reperfusion injury (IRI). PMID: 21721351 [PubMed - indexed for MEDLINE] (Source: Undersea and Hyperbaric Medicine)

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Immunohistochemical expression of apoptosis and VEGF expression on random skin flaps in rats treated with hyperbaric oxygen and N-acetylcysteine.

Undersea and Hyperbaric Medicine — Sat, 30 Apr 2011 23:00:00 +0100

Authors: da Rocha FP, Fagundes DJ, Rivoire HC, Rech FV, Almeida MW, Pires JA We sought to investigate the role of hyperbaric oxygen (HBO2), N-acetylcysteine (NAC), and HBO2 plus NAC (HN) on the immunohistochemical expression of caspase-3 and the vascular endothelial growing factor (VEGF) on random skin flaps of rats (modified McFarlane design). PMID: 21721350 [PubMed - indexed for MEDLINE] (Source: Undersea and Hyperbaric Medicine)

Operative Nd:YAG laser plus postoperative hyperbaric oxygen reduces surgical morbidity after radical head and neck cancer surgery and complex reconstruction.

Undersea and Hyperbaric Medicine — Sat, 30 Apr 2011 23:00:00 +0100

Authors: Slotman GJ, Matthews M, Fahey L, Thom S, Clark J, Hardy K Complications after radical head and neck cancer surgery in irradiated patients are frequent and life-threatening. Hemorrhage, salivary fistulas, wound infections that expose the carotid sheath, among others, make these patients difficult management challenges in the ICU. We studied the effects of Nd:YAG laser surgery plus hyperbaric oxygen (HBO2) therapy on radical head and neck resections and complex reconstruction as a means of reducing postoperative morbidity and mortality. PMID: 21721349 [PubMed - indexed for MEDLINE] (Source: Undersea and Hyperbaric Medicine)

Hyperbaric oxygen: a new adjunctive therapy for surgical-related complications in irradiated advanced cancer patients.

Undersea and Hyperbaric Medicine — Sat, 30 Apr 2011 23:00:00 +0100

Authors: Xiong L PMID: 21721348 [PubMed - indexed for MEDLINE] (Source: Undersea and Hyperbaric Medicine)

Ischemia/reperfusion injury in liver resection: A review of preconditioning methods

Surgery Today — Sat, 30 Apr 2011 16:44:15 +0100

Abstract Ischemic preconditioning is one of the therapeutic interventions aiming at preventing ischemia/reperfusionrelated injury. Numerous experimental studies and a few clinical series have shown that during liver resections, ischemic preconditioning is a promising strategy for optimizing the postoperative outcome. Moreover, various types of pharmacological intervention as well as different types of preconditioning, such as remote preconditioning, the use of heat shock, and hyperbaric oxygen, have been developed to attenuate the functional impairment accompanying ischemia/reperfusion injury. This review summarizes the various forms of preconditioning, thus suggesting that close cooperation between surgeons and anesthesiologists paves the way to apply novel strategies to ...

Methylene Chloride Intoxication Treated With Hyperbaric Oxygen Therapy

The American Journal of Medicine — Fri, 29 Apr 2011 22:21:12 +0100

The vast majority of carbon monoxide (CO) poisoning cases are caused by direct inhalation, but it can still be an elusive diagnosis in unresponsive individuals with no known history of exposure. Herein, we describe a case of methylene chloride (MeCl2) intoxication after the use of this substance as a solvent for paint removal. (Source: The American Journal of Medicine)

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Hyperbaric hyperoxia reduces exercising forearm blood flow in humans

AJP: Heart and Circulatory Physiology — Thu, 28 Apr 2011 23:00:00 +0100

Hypoxia during exercise augments blood flow in active muscles to maintain the delivery of O2 at normoxic levels. However, the impact of hyperoxia on skeletal muscle blood flow during exercise is not completely understood. Therefore, we tested the hypothesis that the hyperemic response to forearm exercise during hyperbaric hyperoxia would be blunted compared with exercise during normoxia. Seven subjects (6 men/1 woman; 25 ± 1 yr) performed forearm exercise (20% of maximum) under normoxic and hyperoxic conditions. Forearm blood flow (FBF; in ml/min) was measured using Doppler ultrasound. Forearm vascular conductance (FVC; in ml·min–1·100 mmHg–1) was calculated from FBF and blood pressure (in mmHg; brachial arterial catheter). Studies were performed in a hyper...

Hyperbaric oxygen in the treatment of postoperative infections in paediatric patients with neuromuscular spine deformity

European Spine Journal — Wed, 27 Apr 2011 05:43:14 +0100

Abstract The aim of this study is to evaluate possible benefits of hyperbaric oxygen (HBO) therapy in the treatment of deep postoperative infections in six high risk paediatric patients with neuromuscular spine deformity. The study involved review of medical records including radiology, office visits, and telephone contacts for six patients, referred for postoperative HBO therapy in 2003–2005. Infection control and healing without removal of implants or major revision surgery with a minimum of 2-year follow-up after index surgery were considered to represent success. All infections were resolved. Median time for wound healing, normalisation of blood tests and antibiotic weaning were 3 months. Radiological bony fusion, intact implants without any signs of radiolucent ...

Hyperbaric Oxygen for Stroke Treatment

BioMed Central — Tue, 26 Apr 2011 23:00:00 +0100

This is an editorial for the inauguration of the Medical Gas Research and addresses a particular issue of using hyperbaric oxygen for stroke treatment. (Source: BioMed Central)

Hyperbaric oxygen improves ultraviolet B irradiation‐induced melanin pigmentation and diminishes senile spot size

Skin Research and Technology — Fri, 22 Apr 2011 16:14:01 +0100

Conclusion: We concluded that exposure to hyperbaric oxygen used in this study accelerates both the fading in melanin pigmentation and the decrease in senile spot size. (Source: Skin Research and Technology)

Pyoderma gangrenosum: A report of a rare complication after knee arthroplasty requiring muscle flap cover supplemented by negative pressure therapy and hyperbaric oxygen

Journal of Plastic, Reconstructive and Aesthetic Surgery — Fri, 22 Apr 2011 04:00:00 +0100

In conclusion, we suggest a surgical algorithm. This is the first report of PG following knee arthroplasty with the use of both NPT and HBO in order to achieve soft tissue coverage. (Source: Journal of Plastic, Reconstructive and Aesthetic Surgery)

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Hypoxic modification of radiotherapy in squamous cell carcinoma of the head and neck – A systematic review and meta-analysis

Radiotherapy and Oncology — Thu, 21 Apr 2011 23:00:00 +0100

Abstract: Background: The importance of tumour hypoxia for the outcome of radiotherapy has been under investigation for decades. Numerous clinical trials modifying the hypoxic radioresistance in squamous cell carcinoma of the head and neck (HNSCC) have been conducted, but most have been inconclusive, partly due to a small number of patients in the individual trial. The present meta-analysis was, therefore, performed utilising the results from all clinical trials addressing the specific question of hypoxic modification in HNSCC undergoing curative intended primary radiotherapy alone. Methods: A systematic review of published and unpublished data identified 4805 patients with HNSCC treated in 32 randomized clinical trials, applying, normobaric oxygen or carbogen breathing (5 trials); hyperba...

Nuclear weather worsens

NaturalNews.com — Wed, 20 Apr 2011 07:00:00 +0100

(NaturalNews) Every day the news gets worse. Today it was robots telling us that radiation is so hot inside the nuclear plant in Japan that workers will have a hard to impossible time to work in certain areas to recover the plant from worst case scenarios. Radiation levels are just heading up across the board and across continents. Sunday morning the news was so bad that I didn't know what to do or write.I could try screaming but I am not the type...or crying, well that comes almost too easily. Perhaps I am crazy. After all, Ann Coulter got on TV and actually said, "The only good news is that anyone exposed to excess radiation from the nuclear power plants is now probably much less likely to get cancer." And Dr. Josef Oehmen, a research scientist at MIT, said, "I repeat, there was and will...

Prediction of hearing outcomes by distortion product otoacoustic emissions in patients with idiopathic sudden sensorineural hearing loss

Auris, Nasus, Larynx — Tue, 19 Apr 2011 17:12:10 +0100

Abstract: Objective: To investigate whether distortion product otoacoustic emissions (DPOAEs) can be a prognostic indicator of hearing outcomes in patients with idiopathic sudden sensorineural hearing loss (ISSNHL).Methods: Seventy-eight consecutive patients with ISSNHL were enrolled. DPOAEs were measured at the first hospital visit. Two primary pure tones with a frequency ratio (f2/f1) of 1.2 were used at non-equal sound pressure levels (L1/L2=80/70dB SPL). The DPOAE amplitude was measured at the 11 frequencies of 2f1–f2 with f2 varying from 593 to 6031Hz. All the patients received steroid administration in combination with hyperbaric oxygen (HBO) therapy. Hearing recovery was evaluated by the improvement in hearing compared to the unaffected contralateral ear. Correlations between the ...

Hypoxic modification of radiotherapy in squamous cell carcinoma of the head and neck - A systematic review and meta-analysis.

Mon, 18 Apr 2011 23:00:00 +0100

Conclusion: The meta-analysis thus demonstrates that there is level 1a evidence in favour of adding hypoxic modification to radiotherapy of squamous cell carcinomas of the head and neck. PMID: 21511351 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)

Hyperbaric oxygen for carbon monoxide poisoning.

Cochrane Database of Systematic Reviews — Mon, 18 Apr 2011 22:15:04 +0100

Authors: Buckley NA, Juurlink DN, Isbister G, Bennett MH, Lavonas EJ Poisoning with carbon monoxide (CO) remains an important cause of accidental and intentional injury worldwide. Several unblinded non-randomized trials have suggested that the use of hyperbaric oxygen (HBO) prevents the development of neurological sequelae. This has led to the widespread use of HBO in the management of patients with carbon monoxide poisoning. PMID: 21491385 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)

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Does hyperbaric oxygen treatment have the potential to increase salivary flow rate and reduce xerostomia in previously irradiated head and neck cancer patients? A pilot study

Oral Oncology — Thu, 14 Apr 2011 23:00:00 +0100

Summary: Irradiated head and neck cancer survivors treated in the Hyperbaric Oxygen (HBO) Unit, Copenhagen University Hospital, spontaneously reported improvement of radiation-induced dry mouth feeling. The aim of this pilot study was to evaluate salivary flow rate and xerostomia before and after HBO in irradiated head and neck cancer patients. Eighty patients eligible for HBO treatment on the indication of prevention/treatment of osteoradionecrosis or soft tissue radiation injury were consecutively sampled, of whom 45 had hyposalivation (i.e. unstimulated whole saliva (UWS) flow rate (Source: Oral Oncology)

Hyperbaric oxygen therapy adjunctive to surgical debridement in management of Fournier's gangrene: usefulness of a severity index score in predicting disease gravity and patient survival.

Actas Urologicas Espanolas — Tue, 12 Apr 2011 23:00:00 +0100

CONCLUSION: FGSI score did not predict disease severity and the patient's survival. Metabolic aberrations, extent of disease seemed to be important risk factors for predicting FG severity and patient survival. PMID: 21496959 [PubMed - as supplied by publisher] (Source: Actas Urologicas Espanolas)

Amy Lutz on ECT

Psych Central — Fri, 08 Apr 2011 20:57:39 +0100

Amy Lutz presented to the U.S. Food and Drug Administration Neurological Devices Panel examining the reclassification of electroconvulsive therapy (ECT) devices on January 27, 2011. These are her remarks as published in the public record of the meeting. Thank you, members of the Panel. My name is Amy Lutz, and my son, Jonah, suffers from autism and rapid cycling bipolar disorder. Until last March, he was plagued by frequent, unpredictable, and violent rages during which he would pound himself in the face like this until he looked like this. I’m showing you these pictures because I need you to understand the state of crisis we lived in for the better part of a decade, and even worse than what he would do to himself was what Jonah would do to others when he was in one of these states. ...

Hyperbaric Oxygen Effects on Sports Injuries

Medscape Today Headlines — Fri, 08 Apr 2011 11:40:54 +0100

The use of hyperbaric oxygen is explored as a method to treat athletes with injuries. Therapeutic Advances in Musculoskeletal Disease (Source: Medscape Today Headlines)

Does delayed hyperbaric oxygen therapy improve neurological outcome in carbon monoxide toxicity?

The Poison Review — Sun, 03 Apr 2011 03:01:57 +0100

1.5 out of 5 stars Factors affecting the prognosis of patients with delayed encephalopathy after acute carbon monoxide poisoning. Hu H et al. Am J Emerg Med 2011 March;29:261-264. Abstract The goal of treating acute carbon monoxide (CO) toxicity with hyperbaric oxygen (HBO) is to prevent delayed neurological sequelae which can occur days or weeks after exposure and follow a period of time during which the patient is lucid and has apparently recovered from the acute poisoning. There is still controversy as to whether treatment with HBO in the acute phase can decrease incidence of delayed sequelae and, if so, in what patients. This paper does not address the possible effectiveness of HBO in acute CO toxicity. Rather, it asks if treatment after delayed sequelae have occurred can improve pro...

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Comparison of therapeutic results in sudden sensorineural hearing loss with/without additional hyperbaric oxygen therapy: a retrospective review of 465 audiologically controlled cases

Clinical Otolaryngology — Thu, 31 Mar 2011 23:00:00 +0100

Conclusions: When applied as an adjuvant to pharmacologic agents, hyperbaric oxygen benefits patients with initial profound sudden sensorineural hearing loss. Therefore, we recommend the routine application of hyperbaric oxygen in conjunction with pharmacologic agents for those patients. The addition of dextran to steroid has no benefit and cannot be recommended. (Source: Clinical Otolaryngology)

Enhancement of reactive oxygen species and induction of apoptosis in streptozotocin-induced diabetic rats under hyperbaric oxygen exposure.

International Journal of Clinical and Experimental Pathology — Wed, 30 Mar 2011 23:00:00 +0100

Authors: Matsunami T, Sato Y, Hasegawa Y, Ariga S, Kashimura H, Sato T, Yukawa M An important source of reactive oxygen species (ROS) production is nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, which on activation induces superoxide production via oxidation in the mitochondria, inflammation and stress; such ROS are implicated in the pathogenesis of diabetic complications, including neuropathy. Hyperbaric oxygen (HBO) treatments are applied various diseases including diabetic patients with unhealing foot ulcers, however, and also increases the formation of ROS. In a previous study, we showed that a clinically recommended HBO treatment significantly enhanced oxidative stress of pancreatic tissue in the diabetic rats. However, no study has been undertaken with regard to the...

Hyperbaric oxygen therapy for transient bone marrow oedema syndrome of the hip.

Hip International — Mon, 28 Mar 2011 23:00:00 +0100

Authors: Capone A, Podda D, Ennas F, Iesu C, Casciu L, Civinini R Abstract. Transient bone marrow oedema syndrome of the proximal femur is characterized by acute, progressive pain in the hip that is increased by weight-bearing. Treatment includes restricted weight-bearing and analgesic medication. A prospective, randomized study was performed to compare two groups of patients affected by bone marrow oedema syndrome of the femoral head. 20 patients received pharmacological and hyperbaric oxygen therapy, and a control group of 21 patients received pharmacological therapy alone. The overall average WOMAC score at 3 months was significantly higher (p<0.001) for the hyperbaric oxygen group (70.8 points) compared with the control group (56.4 points). Magnetic Resonance Imaging at 3 mo...

Delayed neuropsychological sequelae after carbon monoxide poisoning: predictive risk factors in the Emergency Department. A retrospective study. - Pepe G, Castelli M, Nazerian P, Vanni S, Del Panta M, Gambassi F, Botti P, Missanelli A, Grifoni S.

SafetyLit: All (Unduplicated) — Sat, 26 Mar 2011 01:47:23 +0100

BACKGROUND: Delayed neuropsychological sequelae (DNS) commonly occur after recovery from acute carbon monoxide (CO) poisoning. The preventive role and the indications for hyperbaric oxygen therapy in the acute setting are still controversial. Early identif... (Source: SafetyLit: All (Unduplicated))

The Effect of Hyperbaric Oxygenation on Postradiation Xerostomia and Saliva in Patients with Head and Neck Tumours

Karger Publishers — Fri, 25 Mar 2011 15:20:32 +0100

Caries Res 2011;45:136–141 (DOI:10.1159/000324811) (Source: Karger Publishers)

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Efficacy comparison of oral steroid, intratympanic steroid, hyperbaric oxygen and oral steroid + hyperbaric oxygen treatments in idiopathic sudden sensorineural hearing loss cases

European Archives of Oto-Rhino-Laryngology — Wed, 23 Mar 2011 06:01:24 +0100

Abstract Idiopathic sudden sensorineural hearing loss is a rare disorder of unknown pathogenesis in which hearing is lost partially or totally. About 60 treatment modalities have been described. We aimed to compare the efficacy of hyperbaric oxygen, oral steroid, intratympanic steroid therapy and their combinations in idiopathic sudden sensorineural hearing loss patients. Files of patients who were followed up between 2004 and 2010 in our clinic were examined retrospectively. Patients were divided into four groups according to the therapy received: Oral steroid, oral steroid + hyperbaric oxygen, intratympanic steroid and hyperbaric oxygen. Treatment success was assessed by Siegel criteria and mean gains using pre-treatment and post-treatment audiograms. 217 patie...

Methemoglobinemia in aluminum phosphide ingestion: an effect of toxin or treatment?

The Poison Review — Tue, 22 Mar 2011 01:41:31 +0100

1.5 out of 5 stars Methemoglobinemia in aluminum phosphide poisoning. Shadnia S et al. Hum Exp Toxicol 2011 Mar;30(3):250-3. Abstract As TPR noted in a recent post, aluminum phosphide (AlP) is an agent commonly used for suicide in developing countries. It is a strong gastrointestinal irritant, causing rapid onset severe vomiting and abdominal pain. Phosphine — a colorless, flammable, highly toxic gas — is formed when AlP comes into contact with moisture or acid. Phosphine is also a potent cellular poison, impairing mitochondrial function by blocking cytochrome c oxidase, as well as producing free radicals and lipid peroxidation. AlP kills quickly from multi-system failure and cardiovascular collapse. This brief report, from the Loghman Hakim Hospital Poison Center in Tehran, desc...

Phase II Trial of Radiotherapy After Hyperbaric Oxygenation With Multiagent Chemotherapy (Procarbazine, Nimustine, and Vincristine) for High-Grade Gliomas: Long-Term Results

International Journal of Radiation Oncology * Biology * Physics — Mon, 21 Mar 2011 04:00:00 +0100

Conclusions: Radiotherapy delivered immediately after HBO with multiagent chemotherapy was safe, with virtually no late toxicities, and seemed to be effective in patients with high-grade gliomas. (Source: International Journal of Radiation Oncology * Biology * Physics)

Study Shows SANUWAVE's Dermapace Is Significantly More Effective Than Hyperbaric Oxygen Therapy In Healing Chronic Diabetic Foot Ulcers

Health News from Medical News Today — Fri, 18 Mar 2011 08:00:00 +0100

SANUWAVE Health, Inc. (OTCBB: SNWV), an emerging medical technology company focused on the development and commercialization of non-invasive, biological response activating devices in regenerative medicine, announced the publication of research conducted in Taiwan comparing the effectiveness of the Company's dermaPACE® device with hyperbaric oxygen therapy (HBOT) in treating chronic diabetic foot ulcers. The study, entitled "Treatment of Diabetic Foot Ulcers: A Comparative Study of Extracorporeal Shockwave Therapy and Hyperbaric Oxygen Therapy," by Wang, C.J. et al... (Source: Health News from Medical News Today)

Hyperbaric hyperoxia reduces exercising forearm blood flow in humans.

American Journal of Physiology. Heart and Circulatory Physiology — Fri, 18 Mar 2011 00:00:00 +0100

Authors: Casey DP, Joyner MJ, Claus PL, Curry TB Hypoxia during exercise augments blood flow in active muscles to maintain the delivery of O(2) at normoxic levels. However, the impact of hyperoxia on skeletal muscle blood flow during exercise is not completely understood. Therefore, we tested the hypothesis that the hyperemic response to forearm exercise during hyperbaric hyperoxia would be blunted compared to exercise during normoxia. Seven subjects (6M/1F; 25±1 years) performed forearm exercise (20% of maximum) under normoxic and hyperoxic conditions. Forearm blood flow (FBF; ml min(-1)) was measured using Doppler ultrasound. Forearm vascular conductance (FVC; ml min(-1) 100 mmHg(-1)) was calculated from FBF and blood pressure (mmHg; brachial arterial catheter). Studies were perform...

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Delayed neuropsychological sequelae after carbon monoxide poisoning: predictive risk factors in the Emergency Department. A retrospective study

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine — Thu, 17 Mar 2011 00:00:00 +0100

Conclusions: Our study identified several potential predictive risk factors for DNS. Treatment algorithms based on an appropriate risk-stratification of patients in the Emergency Department might reduce DNS incidence; however, more studies are needed. Adequate follow-up after hospital discharge, aimed at correct recognition of DNS, is also important. (Source: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine)

Proton Magnetic Resonance Spectroscopy and MRI Reveal No Evidence for Brain Mitochondrial Dysfunction in Children with Autism Spectrum Disorder.

Journal of Autism and Developmental Disorders — Tue, 15 Mar 2011 00:00:00 +0100

Authors: Corrigan NM, Shaw DW, Richards TL, Estes AM, Friedman SD, Petropoulos H, Artru AA, Dager SR Brain mitochondrial dysfunction has been proposed as an etiologic factor in autism spectrum disorder (ASD). Proton magnetic resonance spectroscopic imaging ((1)HMRS) and MRI were used to assess for evidence of brain mitochondrial dysfunction in longitudinal samples of children with ASD or developmental delay (DD), and cross-sectionally in typically developing (TD) children at 3-4, 6-7 and 9-10 years-of-age. A total of 239 studies from 130 unique participants (54ASD, 22DD, 54TD) were acquired. (1)HMRS and MRI revealed no evidence for brain mitochondrial dysfunction in the children with ASD. Findings do not support a substantive role for brain mitochondrial abnormalities in the etiology ...

DUET - Hyperbaric oxygen therapy for multiple sclerosis

Neurological Conditions Specialist Library — Thu, 10 Mar 2011 11:21:04 +0100

We found no consistent evidence to confirm a beneficial effect of hyperbaric oxygen therapy for the treatment of multiple sclerosis and do not believe routine use is justified. (Source: Neurological Conditions Specialist Library)

Bell's palsy

Clinical Evidence — Mon, 07 Mar 2011 23:00:00 +0100

New option(s) added for: Hyperbaric oxygen therapy New option added with one RCT comparing hyperbaric oxygen versus corticosteroids. The RCT found that a higher proportion of people completely recovered with hyperbaric oxygen compared with corticosteroids. It also reported that time to complete recovery was faster with hyperbaric oxygen. Categorised as Unknown effectiveness as there remains insufficient high-quality evidence to assess the effects of hyperbaric oxygen for people with Bell's palsy. New evidence; conclusion confirmed for: Corticosteroids Two systematic reviews added. Both reviews and two large RCTs included in the reviews found that corticosteroids improved rates of complete recovery of facial function...