MedWorm: Cancer Vaccines

Washington Post, 'Marketplace' Examine Issues Related To HPV Vaccines

Health News from Medical News Today — Wed, 10 Mar 2010 12:00:00 +0100

The Washington Post on Tuesday published a list of questions and answers from a Consumer Reports review of the safety and efficacy of Merck's human papillomavirus vaccine, Gardasil. A new report from the Centers for Disease Control and Prevention and FDA found that a few women and girls vaccinated with Gardasil experienced serious complications but that the rates and severity of most side effects appear to be consistent with those of other vaccines, the Post reports. FDA approved the vaccine in 2006 for women and girls ages nine through 26... (Source: Health News from Medical News Today)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

mtm Laboratories Announces The European Launch Of CINtec(R) PLUS

Health News from Medical News Today — Wed, 10 Mar 2010 08:00:00 +0100

mtm laboratories, a privately held diagnostics company announced the launch of CINtec® PLUS, the company's next generation cervical cancer screening product with unmatched accuracy for the screening and management for cervical cancer. CINtec® PLUS will be launched with claims direct in Germany, Italy, Spain, France and the UK, and will also be available in other parts of the world via mtm's nominated distributors.* CINtec® PLUS combines the p16 biomarker, widely validated for diagnostic purposes, with the proliferation marker Ki-67... (Source: Health News from Medical News Today)

mtm Laboratories Announces The European Launch Of CINtec(R) PLUS

Cancer / Oncology News From Medical News Today — Wed, 10 Mar 2010 08:00:00 +0100

Advances in Rational Vaccine Design: Relevance to Infectious Diseases and Cancer (NIH-Only)

Videocast - All Events — Tue, 09 Mar 2010 20:43:00 +0100

Presented by: Gary J. Nabel, M.D., Ph.D.Category: NCI CCR Grand Rounds (NIH Only)Aired date: 03/09/2010 (Source: Videocast - All Events)

News From The Journal Of Clinical Investigation: March 8, 2010

Immune System / Vaccines News From Medical News Today — Tue, 09 Mar 2010 11:00:00 +0100

Warning sign for potential anticancer approach One treatment being investigated as an adjuvant for anticancer immunotherapies is the use of molecules that trigger the proteins TLR7 and TLR8. For example, the TLR7 stimulant imiquimod is used for the treatment of skin cancer and metastatic melanoma... (Source: Immune System / Vaccines News From Medical News Today)

Documentation of preventive screening interventions by general practitioners: a retrospective chart audit

BMC Family Practice — Tue, 09 Mar 2010 00:00:00 +0100

Conclusions: Documentation of preventive screening interventions by general practitioners was relatively low compared to the number of patients eligible for preventive screening. Some physicians opt to screen for PSA and DRE which is not recommended by the Canadian Task Force on Preventive HealthCare. (Source: BMC Family Practice)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Mesothelioma Research: Veterans Receive Support with Department of Defense’s Increase in Funding

Asbestos and Mesothelioma News — Mon, 08 Mar 2010 18:38:36 +0100

The United States Department of Defense has recently announced its intention to increase spending efforts on researching new methods for combating mesothelioma and other asbestos-related diseases. As part of the effort, several million dollars will provide funding for three mesothelioma research projects. The projects will focus on research into early detection of disease and the development of new treatments, including a clinical trial on a vaccine that may significantly improve the prognosis of patients with malignant mesothelioma. Mesothelioma is a rare cancer that typically forms in the lining of the lungs after inhaling airborne asbestos fibers. However, the effects of asbestos exposure are not immediately felt as symptoms often take as long as 20 to 50 years to arise from the time so...

Screening and Identification of Recombinant Anti-Idiotype Antibodies against Gastric Cancer and Colon Cancer Monoclonal Antibodies by a Phage-Displayed Single-Chain Variable Fragment Library

Journal of Biomolecular Screening — Mon, 08 Mar 2010 17:34:28 +0100

Several monoclonal antibodies (McAbs) have been developed that show high sensitivity and specificity to gastric cancer and colorectal cancer. However, few of the antigens recognized by these antibodies have been identified. The authors now report the selection of anti-idiotype (anti-id) antibodies of MGb1 McAb against gastric cancer and MC5 McAb against colorectal cancer using phage-displayed single-chain variable fragment (ScFv) libraries. After purification, the anti-id antibodies were approximately 30 kd and could be recognized by MGb1/MC5 McAb. Anti-id antibodies significantly blocked the binding of MGb1 and MC5 to gastric cancer/colorectal cancer cells, respectively, suggesting that the antibodies were specific to MGb1 and MC5. Antibodies against gastric and colorectal cancer could be...

Long-Term Survival and PSA Control with Radiation and Immunotherapy for Node Positive Prostate Cancer

Clinical and Developmental Immunology — Mon, 08 Mar 2010 13:39:21 +0100

We describe a patient with node positive prostate cancer treated with radiation, androgen deprivation, and immunotherapy with long-term overall survival and PSA control. ELISPOT immunoassay studies demonstrated PSA specific T-cells prior to starting vaccine therapy suggesting that this positive response may be related to an improved antitumor immune response of the patient, increased immunogenicity of the tumor, or decreased activation of immune escape pathways. Further evaluation of therapeutic cancer vaccines in combination with radiation and hormonal therapy in the definitive management of prostate cancer is warranted. (Source: Clinical and Developmental Immunology)

Nigeria: GSK Slashes Cancer Vaccine Price

AllAfrica News: Health and Medicine — Mon, 08 Mar 2010 09:26:08 +0100

As Nigeria joins the rest of the world today to mark the International Women's Day, Multinational Pharmaceutical Company, GlaxoSmithKline (GSK), has announced a reduction in the price of its cervical cancer vaccine by 50 per cent, to allow more women and girls to be vaccinated against the deadly disease. (Source: AllAfrica News: Health and Medicine)

Immunotherapy to Fight Mesothelioma?

Medical Headlines From Ivanhoe.com — Mon, 08 Mar 2010 05:00:00 +0100

(Ivanhoe Newswire) -- A vaccine that uses a patient's own cells may be able to fight a rare cancer and increase length of survival. (Source: Medical Headlines From Ivanhoe.com)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

BioVex Initiates Phase 1 Clinical Trial With Its Genital Herpes Vaccine, ImmunoVEXHSV2

Health News from Medical News Today — Sun, 07 Mar 2010 08:00:00 +0100

BioVex Inc, a private biotechnology company developing new generation biologics for the treatment of cancer and prevention of infectious disease, announced that the first subject had been dosed in the Phase 1 study of its live attenuated genital herpes vaccine, ImmunoVEXHSV2. The Phase 1 study is an open label ascending dose trial, assessing safety and immune response in healthy volunteers. The study is taking place in the UK at the Chelsea and Westminster Hospital in London and will involve up to 42 already identified subjects. The principle investigator is Dr. Simon Barton... (Source: Health News from Medical News Today)

BioVex Initiates Phase 1 Clinical Trial With Its Genital Herpes Vaccine, ImmunoVEXHSV2

Immune System / Vaccines News From Medical News Today — Sun, 07 Mar 2010 08:00:00 +0100

BioVex Inc, a private biotechnology company developing new generation biologics for the treatment of cancer and prevention of infectious disease, announced that the first subject had been dosed in the Phase 1 study of its live attenuated genital herpes vaccine, ImmunoVEXHSV2. The Phase 1 study is an open label ascending dose trial, assessing safety and immune response in healthy volunteers... (Source: Immune System / Vaccines News From Medical News Today)

Breastfeeding protects children against peptic ulcer bacterium

EurekAlert! - Medicine and Health — Sun, 07 Mar 2010 05:00:00 +0100

(University of Gothenburg) Young children in developing countries are infected at an early age with the bacterium Helicobacter pylori, which can cause peptic ulcers and stomach cancer. New findings show that childrens´ immune responses help in fighting the bacteria. In addition, breastfeeding and better hygiene appear to protect against infection. The results provide hope for a vaccine, according to research from the Sahlgrenska Academy at the University of Gothenburg, Sweden. (Source: EurekAlert! - Medicine and Health)

The quality of life of patients with genital warts: a qualitative study

BMC Public Health - Latest articles — Sun, 07 Mar 2010 00:00:00 +0100

Conclusions: The men and women participating in this study considered their quality of life to be significantly lowered because of genital warts. The experiences described by the participants give insights that may be valuable in treatment and counselling.The quadrivalent HPV vaccine that has now been added to the childhood vaccination programme for girls in Denmark for the prevention of cervical cancer can also prevent 90% of cases of genital warts. Our results suggest that HPV vaccination could considerably reduce the largely unacknowledged psychological and social burden associated with genital warts, in men as well as women. (Source: BMC Public Health - Latest articles)

Health headlines: Binge drinking, Wii workout games and CPR

Thrive, Children's Hospital Boston — Sat, 06 Mar 2010 13:00:37 +0100

Other stories we’ve been reading: Read one father’s story on how he became an advocate for safer teen driving. Check out these safe driving tips for your teen. [Read about the dangers of drowsy driving.] Advertising guilt doesn’t curb binge drinking. Teen alcohol and marijuana use is on the rise. [A recent teen drug survey predicted this.] Young people who smoke marijuana for long periods of time are more likely to risk psychosis. Despite studies proving otherwise, some parents still believe that vaccines cause autism. Gene therapy is closer to restoring eyesight to blind patients. [Read about how a novel surgery saves one baby’s vision.] A blood test can help sort out milk allergies. [Watch Brett go through a milk exposure desensitization trial.] Screening athletes could prevent s...

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

The Effects Of Patient Attitudes On Patient Outcomes

Immune System / Vaccines News From Medical News Today — Fri, 05 Mar 2010 08:00:00 +0100

Research published in the March edition of the Journal of Thoracic Oncology (JTO) explored the importance of a patient's outlook as it relates to health behavior and health status. Researchers focused on lung cancer patients and discovered that those who exhibited an optimistic disposition experienced more favorable outcomes than those with a pessimistic disposition... (Source: Immune System / Vaccines News From Medical News Today)

Vaccine for Asbestos-Related Cancer Looks Safe

MedicineNet Cancer General — Fri, 05 Mar 2010 07:00:00 +0100

Title: Vaccine for Asbestos-Related Cancer Looks SafeCategory: Health NewsCreated: 3/4/2010 12:10:00 PMLast Editorial Review: 3/5/2010 (Source: MedicineNet Cancer General)

Possible Vaccine For Mesothelioma Proven Safe

Health News from Medical News Today — Fri, 05 Mar 2010 06:00:00 +0100

Researchers have demonstrated the safety of a potential vaccine against mesothelioma, a rare cancer associated primarily with asbestos exposure. The vaccine, which infuses uses a patient's own dendritic cells (DC) with antigen from the patient's tumor, was able to induce a T-cell response against mesothelioma tumors. "[This] is the first human study on DC-based immunotherapy in patients with mesothelioma," wrote Joachim G Aerts M.D., Ph.D., a pulmonary physician at Erasmus Medical Center in the Netherlands... (Source: Health News from Medical News Today)

Possible Vaccine For Mesothelioma Proven Safe

Immune System / Vaccines News From Medical News Today — Fri, 05 Mar 2010 06:00:00 +0100

Efficient co-transduction of adenoviral vectors encoding carcinoembryonic antigen and survivin into dendritic cells by the CAR-TAT adaptor molecule enhance antitumor immunity in a murine colorectal cancer model.

Immunology Letters — Fri, 05 Mar 2010 00:00:00 +0100

Authors: Kim HS, Kim CH, Park MY, Park JS, Park HM, Sohn HJ, Kim HJ, Kim SG, Oh ST, Kim TG Because multiple tumor antigens, including carcinoembryonic antigen (CEA) and survivin (SVV), have been frequently observed in human colorectal cancer, we investigated whether the expression of both CEA and SVV by co-transduction of adenovirus vectors into dendritic cells (DC) could improve antitumor immunity in a murine colorectal cancer model. The adaptor fusion protein of Coxsackie and adenovirus receptor and TAT-protein transduction domain (CAR-TAT) enhanced co-transduction of adenovirus vectors encoding CEA (AdCEA) and SVV (AdSVV) into DCs, and increased antitumor immunity. DCs expressing both CEA and SVV in the presence of CAR-TAT (DC-AdCEA/AdSVV+CAR-TAT) induced T-cell responses specific f...

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Vaccine for Asbestos-Related Cancer Looks Safe

MedlinePlus Health News — Thu, 04 Mar 2010 17:00:00 +0100

In tests, novel immunotherapy appears to combat mesothelioma tumors Source: HealthDay Related MedlinePlus Pages: Immunization, Mesothelioma (Source: MedlinePlus Health News)

Vaccine may shift brain cancer odds

CNN.com - Health — Thu, 04 Mar 2010 15:31:53 +0100

Karen Vaneman got a form of brain cancer that most doctors will tell you is invariably fatal. Today, she's beating the odds -- with the help of an experimental vaccine. How many others will benefit? (Source: CNN.com - Health)

Cause Of Destructive Inflammations Discovered

Biology / Biochemistry News From Medical News Today — Thu, 04 Mar 2010 14:00:00 +0100

The signaling molecule CD95L, known as "death messenger," causes an inflammatory process in injured tissue after spinal cord injuries and prevents its healing. This discovery was published by scientists of the German Cancer Research Center. In mice, the researchers found out that if they switch off CD95L, the injured spinal cord heals and the animals regain better ability to move... (Source: Biology / Biochemistry News From Medical News Today)

Cause Of Destructive Inflammations Discovered

Health News from Medical News Today — Thu, 04 Mar 2010 14:00:00 +0100

The signaling molecule CD95L, known as "death messenger," causes an inflammatory process in injured tissue after spinal cord injuries and prevents its healing. This discovery was published by scientists of the German Cancer Research Center. In mice, the researchers found out that if they switch off CD95L, the injured spinal cord heals and the animals regain better ability to move. Therefore, substances which block the death messenger might offer a new approach in the treatment of severe inflammatory diseases. A couple of years ago, Dr... (Source: Health News from Medical News Today)

Possible vaccine for mesothelioma proven safe

EurekAlert! - Medicine and Health — Thu, 04 Mar 2010 05:00:00 +0100

(American Thoracic Society) Researchers have demonstrated the safety of a potential vaccine against mesothelioma, a rare cancer associated primarily with asbestos exposure. The vaccine, which infuses uses a patient's own dendritic cells with antigen from the patient's tumor, was able to induce a T-cell response against mesothelioma tumors. (Source: EurekAlert! - Medicine and Health)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Possible vaccine for mesothelioma proven safe

ScienceDaily Headlines — Thu, 04 Mar 2010 05:00:00 +0100

Obesity and Receipt of Clinical Preventive Services in Veterans.

Obesity — Thu, 04 Mar 2010 00:00:00 +0100

Authors: Yancy WS, McDuffie JR, Stechuchak KM, Olsen MK, Oddone EZ, Kinsinger LS, Datta SK, Fisher DA, Krause KM, Ostbye T Although obese individuals utilize health care at higher rates than their normal weight counterparts, they may be less likely to receive certain preventive services. We conducted a retrospective cohort study of veterans with visits to 136 national Veterans Affairs (VA) outpatient clinics in the United States in the year 2000. The cohort included 1,699,219 patients: 94% men, 48% white, and 76% overweight or obese. Overweight and obese patients had higher adjusted odds of receiving each of the targeted clinical preventive services as recommended over 5 years compared with normal weight patients. The odds for receiving vaccinations increased linearly with BMI category...

AmpVacs A Broadly Protective Synthetic Influenza A Vaccine

Health News from Medical News Today — Wed, 03 Mar 2010 12:00:00 +0100

Sanquin Blood Supply Foundation, the Netherlands Cancer Institute, and the Netherlands Vaccine Institute announce the launch of their joint AmpVacs project aiming at the development of a broadly protective synthetic influenza A vaccine component that in combination with classical antibody-stimulating vaccines will induce protection against future influenza A threats... (Source: Health News from Medical News Today)

AmpVacs A Broadly Protective Synthetic Influenza A Vaccine

Immune System / Vaccines News From Medical News Today — Wed, 03 Mar 2010 12:00:00 +0100

Impact of Human Papillomavirus (HPV)-6/11/16/18 Vaccine on All HPV-Associated Genital Diseases in Young Women

JNCI — Tue, 02 Mar 2010 21:01:22 +0100

Conclusions High-coverage HPV vaccination programs among adolescents and young women may result in a rapid reduction of genital warts, cervical cytological abnormalities, and diagnostic and therapeutic procedures. In the longer term, substantial reductions in the rates of cervical, vulvar, and vaginal cancers may follow. (Source: JNCI)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

PadKit(R) Collection System Selected By UCLA School Of Nursing For Its Grant Funded Cervical Cancer Study

Health News from Medical News Today — Tue, 02 Mar 2010 12:00:00 +0100

CytoCore Inc. (OTCBB:CYOE), the developer of cost-effective products used in the practice of cytology for the detection and diagnosis of cancer and cancer related diseases, announced today that PadKit® Collection Kit, a transport kit using an intralabial device for the collection of gynecological samples, has been selected by the UCLA School of Nursing as the sample collection system for a comparative cytology study of cervical cancer. Led by UCLA School of Nursing Associate Professor Dr... (Source: Health News from Medical News Today)

PadKit(R) Collection System Selected By UCLA School Of Nursing For Its Grant Funded Cervical Cancer Study

Cancer / Oncology News From Medical News Today — Tue, 02 Mar 2010 12:00:00 +0100

CytoCore Inc... (Source: Cancer / Oncology News From Medical News Today)

Breastfeeding Protects Children Against Peptic Ulcer Bacterium

Health News from Medical News Today — Tue, 02 Mar 2010 08:00:00 +0100

Young children in developing countries are infected at an early age with the bacterium Helicobacter pylori, which can cause peptic ulcers and stomach cancer. New findings show that childrensÂ´ immune responses help in fighting the bacteria. In addition, breastfeeding and better hygiene appear to protect against infection. The results provide hope for a vaccine, according to research from the Sahlgrenska Academy at the University of Gothenburg, Sweden... (Source: Health News from Medical News Today)

Breastfeeding Protects Children Against Peptic Ulcer Bacterium

Immune System / Vaccines News From Medical News Today — Tue, 02 Mar 2010 08:00:00 +0100

Young children in developing countries are infected at an early age with the bacterium Helicobacter pylori, which can cause peptic ulcers and stomach cancer. New findings show that childrensÂ´ immune responses help in fighting the bacteria. In addition, breastfeeding and better hygiene appear to protect against infection... (Source: Immune System / Vaccines News From Medical News Today)

Parents Still Worried About Vaccine Safety

MedicineNet Cancer General — Mon, 01 Mar 2010 07:00:00 +0100

Title: Parents Still Worried About Vaccine SafetyCategory: Health NewsCreated: 3/1/2010 10:10:00 AMLast Editorial Review: 3/1/2010 (Source: MedicineNet Cancer General)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Primary Care of the Transplant Patient

The American Journal of Medicine — Mon, 01 Mar 2010 00:00:00 +0100

Abstract: A total of 153,245 patients are living with a solid organ transplant in the US. In addition, patients are experiencing high 5-year survival rates after transplantation. Thus, primary care physicians will be caring for transplanted patients. The aim of this review is to update primary care physicians on chronic diseases, screening for malignancy, immunizations, and contraception in the transplant patient. Several studies on the treatment of hypertension and hyperlipidemia demonstrate that most agents used to treat the general population also can be used to treat transplant recipients. Little information exists on the medical management of diabetes in the transplant population, but experts in the area believe that the treatment of diabetes should be similar. Transplant recipients a...

Prevalence and distribution of human papillomavirus types in cervical cancer, squamous intraepithelial lesions, and with no intraepithelial lesions in women from Southern Mexico.

Gynecologic Oncology — Mon, 01 Mar 2010 00:00:00 +0100

CONCLUSION.: This study contributes to the knowledge of regional prevalence of HPV types in the whole spectrum of disease, which can be useful in the application of prophylactic vaccines against HPV and in the viral screening methods. PMID: 20199804 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

"Is cancer contagious?": Australian adolescent girls and their parents: Making the most of limited information about HPV and HPV vaccination.

Vaccine — Sun, 28 Feb 2010 00:00:00 +0100

DISCUSSION: Low levels of knowledge and understanding about HPV vaccination among adolescents and parents have implications for adolescents' future health practices, including sexual risk behaviour, condom usage, and cervical screening. Reasons for the low levels of knowledge are explored, as are implications for school-based educational interventions. PMID: 20199758 [PubMed - as supplied by publisher] (Source: Vaccine)

The Health Technology Assessment of bivalent HPV vaccine Cervarix((R)) in Italy.

Vaccine — Sat, 27 Feb 2010 00:00:00 +0100

CONCLUSION: The thoroughness of the evaluation allowed us accounting for all the aspects of HPV infection/diseases. The HTA report on the HPV vaccine demonstrated to be a comprehensive tool for an informed decision making process. PMID: 20197141 [PubMed - as supplied by publisher] (Source: Vaccine)

Immunogenicity and some safety features of a VEGF-based cancer therapeutic vaccine in rats, rabbits and non-human primates.

Vaccine — Sat, 27 Feb 2010 00:00:00 +0100

Authors: Morera Y, Bequet-Romero M, Ayala M, Velazco JC, Pérez PP, Alba JS, Ancizar J, Rodríguez M, Cosme K, Gavilondo JV We have developed a cancer vaccine candidate (hereafter denominated CIGB-247), based on recombinant modified human vascular endothelial growth factor (VEGF) as antigen, and the adjuvant VSSP (very small sized proteoliposomes of Neisseria meningitidis outer membrane). In mice, previous work of our group had shown that vaccination with CIGB-247 extended tumor-take time, slowed tumor growth, and increased animal survival. Immunization elicited anti-human and murine VEGF-neutralizing antibodies, and spleen cells of vaccinated mice are cytotoxic in vitro to tumor cells that produce VEGF. We have now tested the immunogenicity of CIGB-247 in Wistar rats, New Zeal...

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Mortality after Chronic Hepatitis B Virus Infection: A Linkage Study Involving 2 Million Parous Women from Taiwan

The Journal of Infectious Diseases Latest Issue — Fri, 26 Feb 2010 21:50:17 +0100

Conclusions. Our study found an excess risk of death due to both liver‐specific and non–liver‐related causes for HBsAg‐positive women in Taiwan. Effective prevention and treatment of hepatitis B virus infection is an important public health priority. (Source: The Journal of Infectious Diseases Latest Issue)

Advances in Rational Vaccine Design: Relevance to Infectious Diseases and Cancer (NIH-Only)

Videocast - All Events — Fri, 26 Feb 2010 14:21:00 +0100

NCI’s Center for Cancer Research (CCR) Grand Rounds is a weekly lecture series addressing current research in clinical and molecular oncology. Speakers are leading national and international researchers and clinicians proposed by members of the CCR Grand Rounds Planning Committee and others within the CCR community and approved by the CCR Office of the Director. Lectures occur every Tuesday from 8:00 to 9:00 a.m. in Lipsett Amphitheater in the Clinical Center building on the NIH campus September through July with exceptions around holidays and major cancer meetings. The lecture schedule is posted on various calendars of events, including at the following link: http://bethesdatrials.cancer.gov/health-care-professionals/grand-rounds.aspx. Air date: 3/9/2010 8:00:00 AM (Source: Videocast - ...

Study Of Costa Rican Women Shows HPV Vaccine Of Little Benefit To Women Over Age 40

Health News from Medical News Today — Fri, 26 Feb 2010 13:00:00 +0100

Women older than age 40 are not likely to receive a substantial benefit from vaccination against the human papillomavirus, according to a study published in the Journal of the National Cancer Institute, the New York Times reports. Although HPV infection is more common in older women, the study found that the rate of newly detected cases declined with age, from 35% of cases in women ages 18 through 25 to 13.5% of cases in women age 42 and older... (Source: Health News from Medical News Today)

New Cancer-Fighting Strategy Focuses On Signaling Molecules

Immune System / Vaccines News From Medical News Today — Fri, 26 Feb 2010 09:00:00 +0100

Cancer researchers studying the immune system have identified a previously unrecognized set of targets and biomarkers to battle solid tumors. The findings center on discovery of signaling molecules that are major players in a biochemical mechanism linking certain actions of B cells to solid tumor growth... (Source: Immune System / Vaccines News From Medical News Today)

Top Doctors To Present Results Of FDA Clinical Trial Of Guided Therapeutics' Cervical Cancer Detection Technology At Scientific Meeting

Health News from Medical News Today — Thu, 25 Feb 2010 10:00:00 +0100

Results of the U.S. Food and Drug Administration (FDA) pivotal clinical trial for the Guided Therapeutics, Inc. (GT) (Pink Sheets: GTHP) LightTouch™ Non-invasive Cervical Cancer Detection System are scheduled to be presented by five leading doctors at the American Society for Colposcopy and Cervical Pathology biennial meeting, March 24 - 27, 2010, in Las Vegas. "Having five peer-reviewed presentations, submitted by recognized experts from nine leading medical institutions, is a testament to the potential for our technology to have a positive affect on women's health," said Mark L... (Source: Health News from Medical News Today)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Cytotoxic T lymphocyte epitopes from human heparanase can elicit a potent anti-tumor immune response in mice

Cancer Immunology, Immunotherapy — Thu, 25 Feb 2010 06:49:09 +0100

Abstract Heparanase is expressed in almost all advanced tumors, and therefore it may serve as a potential target for tumor therapy. Our previous study has shown that heparanase can serve as a potential universal tumor-associated antigen (TAA) for the immunotherapy of advanced tumors. Further study demonstrated that the HLA-A*0201-restricted Cytotoxic T lymphocytes (CTL) epitopes Hpa525 (PAFSYSFFV), Hpa277 (KMLKSFLKA) and Hpa405 (WLSLLFKKL) from human heparanase could induce a potent anti-tumor immune response in vitro. The present study was designed to investigate whether the above peptides could induce immune responses in mice. Our results demonstrated that the effectors from heparanase peptide-immunized mice could effectively lyse various tumor cells that were heparanase...

Hepatitis B and liver cancer knowledge and practices among healthcare and public health professionals in China: a cross-sectional study

BioMed Central — Thu, 25 Feb 2010 00:00:00 +0100

Conclusions: These results indicate that there is a need for development of effective educational programs to improve HBV knowledge among health professionals and the general public to avoid missed vaccination opportunities, reduce misconceptions, and eliminate discrimination based on chronic hepatitis B in China. (Source: BioMed Central)

Overall Survival Analysis of a Phase II Randomized Controlled Trial of a Poxviral-Based PSA-Targeted Immunotherapy in Metastatic Castration-Resistant Prostate Cancer [Genitourinary Cancer]

Journal of Clinical Oncology — Wed, 24 Feb 2010 23:01:02 +0100

Conclusion PROSTVAC-VF immunotherapy was well tolerated and associated with a 44% reduction in the death rate and an 8.5-month improvement in median OS in men with mCRPC. These provocative data provide preliminary evidence of clinically meaningful benefit but need to be confirmed in a larger phase III study. (Source: Journal of Clinical Oncology)

Vital Signs: Prevention: Older Women Are Not Likely to Benefit From Cervical Cancer Vaccine

NYT > Health — Wed, 24 Feb 2010 21:14:45 +0100

The vaccine for HPV, the virus that causes cervical cancer, is used to prevent new infections, but those occur less frequently in women over 40, a study found. (Source: NYT > Health)

Vital Signs: Prevention: Cervical Cancer Vaccine Shows Little Benefit for Older Women

NYT > Health — Wed, 24 Feb 2010 20:12:37 +0100

The vaccine for HPV, the virus that causes cervical cancer, is used to prevent new infections, but those occur less frequently in women over 40, a study found. (Source: NYT > Health)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Evaluation and Management of Anal Intraepithelial Neoplasia in HIV-Negative and HIV-Positive Men Who Have Sex with Men

Current Infectious Disease Reports — Wed, 24 Feb 2010 06:55:52 +0100

Abstract The incidence of human papillomavirus (HPV)–associated anal cancer in men who have sex with men (MSM) is striking and has not been mitigated by the use of highly active antiretroviral therapy. Detection and treatment of high-grade anal intraepithelial neoplasia (HGAIN) may reduce the incidence of anal cancer. Anal cytology is a useful tool to detect HGAIN; annual screening of HIV-positive MSM and biennial screening of HIV-negative MSM appears to be cost-effective. MSM with abnormal cytology should be referred for high-resolution anoscopy and biopsy. Individuals with HGAIN should receive treatment; treatment modalities for HGAIN demonstrate moderate efficacy and are usually well tolerated, but greater study is required to determine which treatment is optimal. Lar...

Benefit of HPV vaccination, frequent screening for women over 41 is likely to be low, study suggests

ScienceDaily Headlines — Wed, 24 Feb 2010 04:00:00 +0100

The overall potential benefits of human papillomavirus (HPV) vaccinations or frequent HPV screenings for women over the age of 41 are low, concludes a new study. The study found that the rate of new infections preventable by vaccination declines with age. Furthermore, new infections among women at any age typically do not progress to cervical intraepithelial neoplasia grade 2 (CIN 2) or CIN 3, the precursors for cervical cancer. (Source: ScienceDaily Headlines)

A new era in anticancer peptide vaccines

Cancer — Wed, 24 Feb 2010 00:00:00 +0100

The use of synthetic peptides as vaccines aimed at the induction of therapeutic CD8-positive T-cell responses against tumor cells initially experienced great enthusiasm, mostly because of advances in vaccine technology, including design, synthesis, and delivery. However, despite impressive results in animal models, the application of such vaccines in humans has met with only limited success. The therapeutic activity of vaccine-stimulated, tumor-specific, CD8-positive T cells can be hampered through the physical burden of the tumor, tolerance mechanisms, and local factors within the tumor microenvironment. Recently, accumulating evidence has suggested that combining a peptide-based therapeutic vaccination with conventional chemotherapy can uncover the full potential of the antitumor immune ...

Post-licensure monitoring of HPV vaccine in the United States.

Vaccine — Wed, 24 Feb 2010 00:00:00 +0100

Authors: Markowitz LE, Hariri S, Unger ER, Saraiya M, Datta SD, Dunne EF Post-licensure evaluation of vaccines plays an important role in monitoring the progress of immunization programs, demonstrating population impact of vaccines, and providing data for ongoing policy decisions. Two human papillomovirus (HPV) vaccines are licensed and recommended for use in females in the United States, a quadrivalent human HPV vaccine, licensed in 2006 and a bivalent vaccine HPV vaccine licensed in 2009. HPV vaccination is recommended for females 11 or 12 years of age with catch-up vaccination through age 26 years. Post-licensure monitoring of the HPV vaccine program has included some of the same systems established for other vaccines, such as those for vaccine safety and coverage monitoring. Howeve...

Modified Vaccination Technique for Prophylactic and Therapeutic Applications to Combat Endogenous Antigen–Induced Disorders

Scandinavian Journal of Immunology — Tue, 23 Feb 2010 13:37:28 +0100

Public health can be protected most effectively through vaccination programmes. However, while presently available vaccination techniques protects the individual by provoking immune responses against exogenous antigens (ags), such as those associated with certain bacteria and viruses, they cannot protect against or treat mishaps caused by endogenous ag. Recently, Barabas and colleagues have developed a new vaccination method, called modified vaccination technique (MVT), which allows the presentation of disease causing agents in such a way as to initiate and maintain desired immune response outcomes even in the context of mishaps associated with endogenous ag. For example, in an experimental autoimmune kidney disease, the MVT downregulated/terminated pathogenic immune responses that were ca...

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Decreased Incidence of Hepatocellular Carcinoma in Hepatitis B Vaccinees: A 20-Year Follow-up Study

Medscape Today Headlines — Tue, 23 Feb 2010 12:04:40 +0100

This study sought to determine whether prevention of hepatocellular carcinoma (HCC) by hepatitis B vaccination extended beyond childhood and to identify the predictors of HCC for those vaccinated. Journal of the National Cancer Institute (Source: Medscape Today Headlines)

Comparison of human papillomavirus in situ hybridization and p16 immunohistochemistry in the detection of human papillomavirus-associated head and neck cancer based on a prospective clinical experience

Cancer — Tue, 23 Feb 2010 00:00:00 +0100

Human papillomavirus (HPV) is a causative agent in a subset of head and neck squamous cell carcinomas (HNSCCs). These HPV-related cancers have a clinicopathologic profile that diverges from HPV-negative HNSCCs. Accordingly, HPV testing may soon become integrated into standard pathologic assessment of HNSCCs.Data were prospectively collected for all patients with head and neck carcinomas who had undergone HPV testing at the Johns Hopkins Hospital as part of clinical care during a 57-month period. HPV testing consisted of concurrent HPV16 in situ hybridization (ISH) and p16 immunohistochemistry (IHC). Wide spectrum HPV ISH was reserved for p16-positive cases that were HPV-16 negative.HPV analysis was performed on 256 head and neck carcinomas in an effort to predict clinical outcomes (56%), l...

An Adenoviral Vaccine Encoding Full-Length Inactivated Human Her2 Exhibits Potent Immunogenicty and Enhanced Therapeutic Efficacy without Oncogenicity.

Clinical Breast Cancer — Tue, 23 Feb 2010 00:00:00 +0100

CONCLUSIONS: Vaccination with mutationally inactivated, nononcogenic Ad-HER2-ki results in robust polyclonal immune responses to HER2 in tolerant models, which translates into strong and effective antitumor responses in vivo. Ad-HER2-ki is thus a safe and promising vaccine for evaluation in clinical trials. Clin Cancer Res; 16(5); 1466-77. PMID: 20179231 [PubMed - as supplied by publisher] (Source: Clinical Breast Cancer)

Anti-cancer activity of the HIV accessory molecule viral protein R (Vpr): Delivery as a DNA expression plasmid or biologically active peptides.

Vaccine — Tue, 23 Feb 2010 00:00:00 +0100

Authors: Muthumani K, Lambert VM, Kawalekar O, Heller R, Kim JJ, Weiner DB, Ugen KE By virtue of its ability to induce cell cycle arrest and apoptosis, the HIV accessory protein Vpr (viral protein R) has been evaluated by us and others as an anti-proliferative/anti-cancer agent. We have demonstrated that Vpr, when delivered to established experimental B16.F10 melanoma tumors in mice as a DNA expression plasmid through in vivo electroporation, can result in complete regression of the established tumors. We have also demonstrated that Vpr peptides from the carboxy region of the protein can inhibit in vitro growth of both B16.F10 melanoma as well as human HeLa cervical carcinoma tumor cells. These findings, summarized in this report, underscore the potential of Vpr as an anti-cancer agent...

Engineering superior DNA vaccines: MHC class I single chain trimers bypass antigen processing and enhance the immune response to low affinity antigens.

Vaccine — Tue, 23 Feb 2010 00:00:00 +0100

In this study, we tested the efficacy of progressive generations of SCT DNA vaccines engineered to (1) enhance peptide binding, (2) enhance interaction with the CD8 coreceptor, and/or (3) activate CD4(+) helper T cells. Disulfide trap SCT (dtSCT) have been engineered to improve peptide binding, with mutations designed to create a disulfide bond between the class I heavy chain and the peptide linker. dtSCT DNA vaccines dramatically enhance the immune response to model low affinity antigens as measured by ELISPOT analysis and tumor challenge. SCT engineered to enhance interaction with the CD8 coreceptor have a higher affinity for the TCR/CD8 complex, and are associated with more robust CD8(+) T cell responses following vaccination. Finally, SCT constructs that coexpress a universal helper ep...

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

In situ targeting of dendritic cells by antigen-loaded red blood cells: A novel approach to cancer immunotherapy.

Vaccine — Tue, 23 Feb 2010 00:00:00 +0100

Authors: Banz A, Cremel M, Rembert A, Godfrin Y Red blood cells (RBCs) were shown to be efficient antigen carriers to target dendritic cells (DCs) and induce cytotoxic T-cell responses. Mouse RBCs were loaded with ovalbumin (RBC-OVA) and injected with Poly (I:C) into mice. Phagocytosis of RBC-OVA by macrophages and DCs was demonstrated to induce OVA-specific CD4(+) and CD8(+) T cell activation. Moreover, these CD8(+) T cells produced IFN-gamma and were able to induce OVA-specific cell lysis. Finally, T-cell response was demonstrated to be dependent on the dose-amount of antigen entrapped and this response could be maintained for up to 30 days. PMID: 20188177 [PubMed - as supplied by publisher] (Source: Vaccine)

CD122(+)CD8(+) regulatory T cells suppress vaccine-induced antitumor immune responses in lymphodepleted mice.

European Journal of Immunology — Tue, 23 Feb 2010 00:00:00 +0100

Authors: Wang LX, Li Y, Yang G, Pang PY, Haley D, Walker EB, Urba WJ, Hu HM Lymphodeleption prior to adoptive transfer of tumor-specific T cells greatly improves the clinical efficacy of adoptive T-cell therapy for patients with advanced melanoma, and increases the therapeutic efficacy of cancer vaccines in animal models. Lymphodepletion reduces competition between lymphocytes, and thus creates "space" for enhanced expansion and survival of tumor-specific T cells. Within the lymphodepleted host, antigen-specific T cells still need to compete with other lymphocytes that undergo lymphopenia-driven proliferation. Herein we describe the relative capacity of naïve, regulatory T cells, and NK cells to undergo lymphopenia-driven proliferation. We found that the major population that unde...

European Guidelines for Quality Assurance in Cervical Cancer Screening. Second Edition--Summary Document

Annals of Oncology — Mon, 22 Feb 2010 13:25:35 +0100

European Guidelines for Quality Assurance in Cervical Cancer Screening have been initiated in the Europe Against Cancer Programme. The first edition established the principles of organised population-based screening and stimulated numerous pilot projects. The second multidisciplinary edition was published in 2008 and comprises ~250 pages divided into seven chapters prepared by 48 authors and contributors. Considerable attention has been devoted to organised, population-based programme policies which minimise adverse effects and maximise benefits of screening. It is hoped that this expanded guidelines edition will have a greater impact on countries in which screening programmes are still lacking and in which opportunistic screening has been preferred in the past. Other methodological aspect...

News Outlets Examine HIV Vaccine Research, Cervical Cancer Screening Data Presented At Conference

Immune System / Vaccines News From Medical News Today — Mon, 22 Feb 2010 10:00:00 +0100

Several news outlets examine the latest reports out of this week's Conference on Retroviruses and Opportunistic Infections (CROI) in San Francisco. Researchers from the Maryland-based VIRxSYS Corporation on Thursday presented data on the outcomes of the company's HIV vaccine, VRX1023, from a recent trial carried out in monkeys, Reuters reports... (Source: Immune System / Vaccines News From Medical News Today)

News Outlets Examine HIV Vaccine Research, Cervical Cancer Screening Data Presented At Conference

Health News from Medical News Today — Mon, 22 Feb 2010 10:00:00 +0100

Several news outlets examine the latest reports out of this week's Conference on Retroviruses and Opportunistic Infections (CROI) in San Francisco. Researchers from the Maryland-based VIRxSYS Corporation on Thursday presented data on the outcomes of the company's HIV vaccine, VRX1023, from a recent trial carried out in monkeys, Reuters reports. The scientists genetically engineered a version of HIV for use in the vaccine, "an approach that has been rejected as unworkable in the past," according to Reuters... (Source: Health News from Medical News Today)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

New strategy produces promising advance in cancer vaccines

ScienceDaily Headlines — Mon, 22 Feb 2010 07:00:00 +0100

Researchers have used a new strategy to develop cancer vaccines that are remarkably effective in mice. The scientists report that 100 percent of the mice vaccinated with a peptide they developed remained alive and tumor-free for at least 60 days after inoculation with colon cancer cells. The research suggests a method for developing vaccines against a wide variety of cancers. (Source: ScienceDaily Headlines)

UA doctor's cancer vaccine to undergo clinical trials in India, US

bizjournals.com Health Care:Biotechnology headlines — Mon, 22 Feb 2010 05:00:00 +0100

Dr. Emmanuel Katsanis, professor of pediatrics, pathology and immunobiology in the University of Arizona’s pediatric department, has developed a personalized cancer vaccine that helps stimulate a patient’s immune system after receiving chemotherapy. (Source: bizjournals.com Health Care:Biotechnology headlines)

Sensitive immunohistochemical detection of WT1 protein in tumors with anti-WT1 antibody against WT1 235 peptide

Cancer Science — Mon, 22 Feb 2010 00:00:00 +0100

The Wilms' tumor 1 (WT1) gene is overexpressed in leukemia and various types of solid tumor, such as lung and colorectal cancer, and plays an oncogenic role in their tumorigenesis. Recent studies have demonstrated the potential of WT1-targeting cancer immunotherapy in clinical settings. As expression of WT1 protein in tumor cells is a prerequisite for WT1-targeting immunotherapy, immunohistochemical methods to detect WT1 protein with high sensitivity and specificity are required. In the present study, we developed a rabbit polyclonal antibody (WT1-R) against the 9-mer WT1 235 peptide, which is used for vaccination. The specificity of WT1-R was confirmed by immunoprecipitation, western blotting analysis, and competitive enzyme-linked immunosorbent assay. Immunocytochemistry showed the same ...

Paper round: Monday

OnMedica Latest News — Mon, 22 Feb 2010 00:00:00 +0100

Calls for removing homeopathy funding, "Rent-A-Date" fundraising, and moreRelated items from OnMedicaGas frying meat raises cancer fume riskGet vaccinated warning as H1N1 still activeSuper-sensitive cancer blood tests within five yearsNHS hospital set for private sector managementDon’t worry – be happy (Source: OnMedica Latest News)

Institute of Medicine recommendations for the prevention and control of hepatitis B and C

Hepatology — Mon, 22 Feb 2010 00:00:00 +0100

Conclusion: To address the situation, the Institute of Medicine report makes recommendations in four areas: improved surveillance for HBV and HCV; improved knowledge and awareness among healthcare and social-service providers and the public, especially at-risk people; improved HBV vaccine coverage; and improved viral hepatitis services and access to those services. HEPATOLOGY, 2010 (Source: Hepatology)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Gene-modified tumor vaccine secreting a designer cytokine Hyper-Interleukin-6 is an effective therapy in mice bearing orthotopic renal cell cancer

Kidney Cancer Association — Sat, 20 Feb 2010 16:58:07 +0100

Although Renal Cell Cancer (RCC) is known to be immunogenic, clinical efficacy of various immunotherapeutic approaches remains unsatisfactory. Novel targeted therapies showing cytostatic rather than cytotoxic activity are unable to cure RCC patients. In our studies, we evaluated the therapeutic efficacy of whole-cell vaccine based on irradiated murine RENCA cells genetically modified to secrete designer cytokineHyper-IL6 (H6)comprising IL-6 and soluble IL-6 receptor. An orthotopic RCC model based on a subcapsular implantation of RENCA cells into kidneys of Balb/C mice was employed.02/21/2010 (Source: Kidney Cancer Association)

Are mandatory vaccinations acts of violence against children?

NaturalNews.com — Sat, 20 Feb 2010 07:00:00 +0100

This article refers to the parody cartoon found at (http://www.naturalnews.com/028211_vaccines_Merck.html). This parody cartoon grew out of the idea that vaccines are "shots" that are being increasingly forced upon children and teens. At times, these vaccines are enforced at gunpoint or with the presence of vicious guard dogs -- as happened in Maryland two years ago when a court judge ordered thousands of parents to bring their children to court for vaccination or face gunpoint arrest and possible jail time. (http://www.naturalnews.com/022267.html)Most modern vaccinations are, of course, a form of chemical violence against children. If they were all formulated without chemical preservatives (like thimerosal) and dangerous adjuvants (which can harm the nervous system), that might be a diffe...

Faith makes regulating herbal medicine difficult

Guardian Unlimited Science — Sat, 20 Feb 2010 00:00:01 +0100

A judge this week called for traditional medicine to be regulated, but it's not easy when practitioners make claims based on faithYou may have read about Ying Wu this week: a traditional Chinese medicine doctor operating out of a shop in Chelmsford, Essex, who for several years prescribed pills with high doses of a dangerous substance to treat the acne of senior civil servant Patricia Booth, 58. Following this, her patient lost both kidneys, developed urinary tract cancer, had a heart attack, and is on dialysis three times a week. Judge Jeremy Roberts gave Ying a two-year conditional discharge, saying she could not be blamed, because she did not know the pills were harmful and the practice of traditional Chinese medicine is unregulated in Britain, a situation that he suggests should be rem...

Faith clouds herbal medicine regulation

Guardian Unlimited Science — Sat, 20 Feb 2010 00:00:01 +0100

UF Veterinarians Say Dolphins Could Be Ideal Model To Study Human Cervical Cancer

Health News from Medical News Today — Fri, 19 Feb 2010 15:00:00 +0100

After testing dozens of samples from marine mammals, University of Florida aquatic animal health experts say dolphins may be the ideal model for the study of cervical cancer in people. "We discovered that dolphins get multiple infections of apillomaviruses, which are known to be linked with cervical cancer in women," said Hendrik Nollens, a marine mammal biologist and clinical assistant professor at UF's College of Veterinary Medicine at the annual meeting of the American Academy for the Advancement of Science... (Source: Health News from Medical News Today)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

UF Veterinarians Say Dolphins Could Be Ideal Model To Study Human Cervical Cancer

Genetics News From Medical News Today — Fri, 19 Feb 2010 15:00:00 +0100

Preliminary Data From Roche ATHENA Cervical Cancer Trial Support Value Of Human Papillomavirus Genotyping

Health News from Medical News Today — Fri, 19 Feb 2010 11:00:00 +0100

Roche Molecular Systems, Inc. (SIX: RO, ROG; OTCQX: RHHBY) announced that preliminary data from its ATHENA (Addressing THE Need for Advanced HPV Diagnostics) trial support the importance of screening for human papillomavirus (HPV) genotypes that put women at highest risk for developing cervical cancer. ATHENA is a prospective, double-blind, multi-centered, 47,000-patient, U.S.-registration trial designed to demonstrate the effectiveness of HPV detection as part of a cervical cancer screening program. Thomas C. Wright Jr., M.D... (Source: Health News from Medical News Today)

Preliminary Data From Roche ATHENA Cervical Cancer Trial Support Value Of Human Papillomavirus Genotyping

Pharma Industry News From Medical News Today — Fri, 19 Feb 2010 11:00:00 +0100

Roche Molecular Systems, Inc. (SIX: RO, ROG; OTCQX: RHHBY) announced that preliminary data from its ATHENA (Addressing THE Need for Advanced HPV Diagnostics) trial support the importance of screening for human papillomavirus (HPV) genotypes that put women at highest risk for developing cervical cancer. ATHENA is a prospective, double-blind, multi-centered, 47,000-patient, U.S... (Source: Pharma Industry News From Medical News Today)

Heal yourself in 15 days by correcting your "nature deficiency" (part nine)

NaturalNews.com — Fri, 19 Feb 2010 07:00:00 +0100

(NaturalNews) Do you suffer from a "nature deficiency?" If you'd like most people in modern society, you spend most of your 24 hours of the day indoors. You work under artificial fluorescent lights, you eat and sleep inside a house or apartment, you commute in the artificial environment of a car, bus or train. You rarely get outside and even when you do, it's not real nature -- it's some artificial "planned" park with concrete sidewalks and maintained lawns.I suspect you may have a nature deficiency. I know because I've been there. Probably much like you, I spent a lot of time outdoors as a child, but in my adult years, I found myself spending more and more hours indoors. It didn't take long to realize that breathing re-circulated indoor air and having little or no time in nature wasn't a ...

Screens, Vaccine for HPV Less Beneficial in Older Women

MedicineNet Cancer General — Fri, 19 Feb 2010 07:00:00 +0100

Title: Screens, Vaccine for HPV Less Beneficial in Older WomenCategory: Health NewsCreated: 2/18/2010 2:10:00 PMLast Editorial Review: 2/19/2010 (Source: MedicineNet Cancer General)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

[Correspondence] HPV vaccination: waiting for evidence of effectiveness

LANCET — Fri, 19 Feb 2010 00:00:00 +0100

As noted by Gary Clifford (Dec 12, p 1948), the greatest source of uncertainty about the potential effectiveness of human papillomavirus (HPV) vaccines remains the duration of the immune response. However, even if the most optimistic scenario of HPV vaccine effectiveness is realised, the introduction of HPV vaccines to populations not yet fully covered by screening services may compete with limited budgets for the build-out of screening services and thereby decelerate global reductions in deaths from cervical cancer by creating populations of women who will not be protected by either screening or vaccination. (Source: LANCET)

Paper round: Friday

OnMedica Latest News — Fri, 19 Feb 2010 00:00:00 +0100

Future of elderly care, "little miracle", and moreRelated items from OnMedicaPressure mounts for herbal medicines regulationGas frying meat raises cancer fume riskGet vaccinated warning as H1N1 still activeSuper-sensitive cancer blood tests within five yearsNHS hospital set for private sector management (Source: OnMedica Latest News)

DNA vaccines against cancer come of age.

Current Opinion in Immunology — Fri, 19 Feb 2010 00:00:00 +0100

Authors: Stevenson FK, Ottensmeier CH, Rice J Genetic technology allows construction of DNA vaccines encoding selected tumor antigens together with molecules to direct and amplify the desired effector pathways. Their enormous promise has been marred by a problem of scaling up to human subjects. This is now largely overcome by electroporation, which increases both antigen expression and the inflammatory milieu. While the principles of vaccine design can be developed in mouse models, the real operative test is in the clinic, using patients in temporary remission. Monitoring of induced immunity, although commonly limited to blood, is providing objective qualitative and quantitative data on T-cell and antibody responses. Prolongation of remission is the goal and an activated immune system ...

Screens, Vaccine for HPV Less Beneficial in Older Women

MedlinePlus Health News — Thu, 18 Feb 2010 19:00:00 +0100

Rate of new infections declined with age, study found Source: HealthDay Related MedlinePlus Topics: Cervical Cancer, HPV, Immunization (Source: MedlinePlus Health News)

Autoimmune B-cell lymphopenia after successful adoptive therapy with telomerase-specific T lymphocytes

Blood — Thu, 18 Feb 2010 17:01:20 +0100

Telomerase reverse transcriptase (TERT) is a good candidate for cancer immunotherapy because it is overexpressed in 85% of all human tumors and implicated in maintenance of the transformed phenotype. TERT-based cancer vaccines have been shown to be safe, not inducing any immune-related pathology, but their impact on tumor progression is modest. Here we show that adoptive cell therapy with the use of high-avidity T lymphocytes reactive against telomerase can control the growth of different established tumors. Moreover, in transgenic adenocarcinoma mouse prostate mice, which develop prostate cancer, TERT-based adoptive cell therapy halted the progression to more aggressive and poorly differentiated tumors, significantly prolonging mouse survival. We also demonstrated that human tumors, inclu...

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Vaccine 'prevents male anal cancer'

Pharmacy Europe — Thu, 18 Feb 2010 14:09:33 +0100

Researchers are hoping a vaccine could help protect more women from cervical cancer and also be used to prevent anal cancer in men. (Source: Pharmacy Europe)

Cancer Vaccine by Fusions of Dendritic and Cancer Cells

Clinical and Developmental Immunology — Thu, 18 Feb 2010 13:39:04 +0100

Dendritic cells (DCs) are potent antigen-presenting cells and play a central role in the initiation and regulation of primary immune responses. Therefore, their use for the active immunotherapy against cancers has been studied with considerable interest. The fusion of DCs with whole tumor cells represents in many ways an ideal approach to deliver, process, and subsequently present a broad array of tumor-associated antigens, including those yet to be unidentified, in the context of DCs-derived costimulatory molecules. DCs/tumor fusion vaccine stimulates potent antitumor immunity in the animal tumor models. In the human studies, T cells stimulated by DC/tumor fusion cells are effective in lysis of tumor cells that are used as the fusion partner. In the clinical trials, clinical and immunolog...

Gardasil Effective In Women Ages 25 To 45, Young Men, Merck Studies Show

Health News from Medical News Today — Thu, 18 Feb 2010 11:00:00 +0100

Merck's human papillomavirus vaccine, Gardasil, effectively prevented precancerous cervical lesions and genital warts in women ages 24 through 45, and it prevented anal cancer and precancerous anal lesions in young men who have sex with men, according to two studies released by the company on Wednesday, the AP/Philadelphia Inquirer reports. Merck released the studies in conjunction with a European conference of physicians and researchers who specialize in cancer and genital infections... (Source: Health News from Medical News Today)

Gardasil Effective In Women Ages 25 To 45, Young Men, Merck Studies Show

Men's health News From Medical News Today — Thu, 18 Feb 2010 11:00:00 +0100

Merck's human papillomavirus vaccine, Gardasil, effectively prevented precancerous cervical lesions and genital warts in women ages 24 through 45, and it prevented anal cancer and precancerous anal lesions in young men who have sex with men, according to two studies released by the company on Wednesday, the AP/Philadelphia Inquirer reports... (Source: Men's health News From Medical News Today)

UCLA School Of Nursing Selects QuantRx PadKit(R) Collection System For Grant Funded Cervical Cancer Study

Health News from Medical News Today — Thu, 18 Feb 2010 08:00:00 +0100

QuantRx® Biomedical Corporation (OTCBB:QTXB), an emerging leader in the development and commercialization of innovative diagnostic products based on its patented technology platforms for the worldwide point-of-care healthcare industry, announced that its proprietary PadKit has been selected as the sample collection system by the UCLA School of Nursing for a comparative cytology study of cervical cancer. Led by UCLA School of Nursing Associate Professor Dr... (Source: Health News from Medical News Today)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

UCLA School Of Nursing Selects QuantRx PadKit(R) Collection System For Grant Funded Cervical Cancer Study

Cancer / Oncology News From Medical News Today — Thu, 18 Feb 2010 08:00:00 +0100

QuantRx® Biomedical Corporation (OTCBB:QTXB), an emerging leader in the development and commercialization of innovative diagnostic products based on its patented technology platforms for the worldwide point-of-care healthcare industry, announced that its proprietary PadKit has been selected as the sample collection system by the UCLA School of Nursing for a comparative cyto... (Source: Cancer / Oncology News From Medical News Today)

New uses found for Gardasil vaccine

OrlandoSentinel: Medical Research — Thu, 18 Feb 2010 00:00:00 +0100

New studies show that Merck's Gardasil vaccine appears to protect most young women from cervical cancer and homosexual men from anal cancer. The vaccine is designed to block four of the most common strains of the sexually transmitted human papilloma... (Source: OrlandoSentinel: Medical Research)

Public Health Policy for Management of Hepatitis B Virus Infection: Historical Review of Recommendations for Immunization

Public Health Nursing — Thu, 18 Feb 2010 00:00:00 +0100

ABSTRACT Chronic hepatitis B virus (HBV) infection is the leading cause of cirrhosis, liver failure, and liver cancer, and an estimated 620,000 persons die annually from HBV-related liver disease (Goldstein et al., 2005; World Health Organization, 2000). Immunization with the HBV vaccine is the most effective means of preventing HBV infection and its consequent acute and chronic liver diseases such as cirrhosis and hepatocellular carcinoma. The HBV vaccine has been used against HBV in the United States since 1982 (Centers for Disease Control and Prevention, 1982); during the last 25 years, HBV vaccine policy continued to evolve in response to public health issues and epidemiologic data. Although the number of newly acquired HBV infections has substantially declined as a result of implement...

Study Does Not Support HPV Vaccine in Older Women

Medscape Today Headlines — Wed, 17 Feb 2010 20:07:41 +0100

A new natural-history study of human papillomavirus (HPV) looks at age, persistence of infection, and cervical cancer precursors. Medscape Medical News (Source: Medscape Today Headlines)

Gardasil protects women, men from genital cancers

CTV Health — Wed, 17 Feb 2010 19:50:49 +0100

The Gardasil vaccine protected most young women from cervical cancer and homosexual men from anal cancer, according to new studies released Wednesday by its maker, Merck&Co. (Source: CTV Health)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Gardasil Protects Older Women, Gay Men

U.S. News - Health — Wed, 17 Feb 2010 19:27:00 +0100

The vaccine protects against viruses causing cervical cancer in women up to age 45, new data suggest. (Source: U.S. News - Health)

Gardasil: Wider Use Sought for Vaccine

Health News: CBSNews.com — Wed, 17 Feb 2010 16:30:08 +0100

Studies Show Vaccine To Be Effective In Protecting Many From Cancer (Source: Health News: CBSNews.com)

Gardasil Could Help Older Women, Gay Men

WSJ.com: Health — Wed, 17 Feb 2010 13:20:36 +0100

Merck said said two recent studies of its cervical-cancer vaccine Gardasil showed it could help older women and gay men. (Source: WSJ.com: Health)

Gardasil Helps Prevent Anal Cancer In Men, Showed New Study

Drugs.com - Clinical Trials — Wed, 17 Feb 2010 13:04:46 +0100

KIRKLAND, QC, Feb. 17 /CNW Telbec/ - In a new phase III study, GARDASIL(R) (Quadrivalent Human Papillomavirus (Types 6, 11, 16 and 18) Recombinant Vaccine) prevented 77.5 per cent of anal intraepithelial neoplasia (AIN) associated with... (Source: Drugs.com - Clinical Trials)

Promising Advance In Cancer Vaccines

Health News from Medical News Today — Wed, 17 Feb 2010 12:00:00 +0100

Researchers at National Jewish Health and the University of Colorado School of Medicine have used a new strategy to develop cancer vaccines that are remarkably effective in mice. In the February 16 issue of the Proceedings of the National Academy of Sciences (PNAS), Kimberly Jordan, PhD, Jill Slansky, PhD, and John Kappler, PhD, report that 100 percent of the mice vaccinated with a peptide they developed remained alive and tumor-free for at least 60 days after inoculation with colon cancer cells. The research suggests a method for developing vaccines against a wide variety of cancers... (Source: Health News from Medical News Today)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Promising Advance In Cancer Vaccines

Biology / Biochemistry News From Medical News Today — Wed, 17 Feb 2010 12:00:00 +0100

Cancer Research UK And Immatics Biotechnologies To Trial Vaccine For Brain Cancer

Health News from Medical News Today — Wed, 17 Feb 2010 08:00:00 +0100

Cancer Research UK and Cancer Research Technology - the charity's development and commercialisation arm - have reached a collaboration agreement with immatics Biotechnologies to trial their new treatment vaccine, IMA950, for glioblastoma multiforme (GMB), one of the most common forms of brain cancer*. IMA950 is the fifth treatment to enter Cancer Research UK's Clinical Development Partnerships (CDP) scheme and the second one to be completed this year... (Source: Health News from Medical News Today)

Cancer Research UK And Immatics Biotechnologies To Trial Vaccine For Brain Cancer

Immune System / Vaccines News From Medical News Today — Wed, 17 Feb 2010 08:00:00 +0100

Cancer Research UK and Cancer Research Technology - the charity's development and commercialisation arm - have reached a collaboration agreement with immatics Biotechnologies to trial their new treatment vaccine, IMA950, for glioblastoma multiforme (GMB), one of the most common forms of brain cancer*... (Source: Immune System / Vaccines News From Medical News Today)

Special thank you to all NaturalNews readers from the Health Ranger

NaturalNews.com — Wed, 17 Feb 2010 07:00:00 +0100

(NaturalNews) I've been writing for NaturalNews now for over six years, and in that time the most important thing I've come to realize isn't something about herbs, or nutrients, or Big Pharma... it's that I'm blessed to have you as a reader. And in this thank-you article, I'd like to share exactly why I feel to blessed and honored to continue writing for you.When I was a kid, I used to volunteer in nursing homes. I would bring water to the elderly patients and refill the cups on their bedside stands. At the time, I thought my job was to deliver water -- it wasn't until many years later that I realized my true job was to bring these elderly patients something far more important: The smile and conversation of a young boy. The water was inconsequential compared to the joy these elderly patien...

Health Ranger announces "Healing Miracles LIVE" event in Southern Calif., March 19 - 20, with Horowitz, Whitaker, Gerson and more

NaturalNews.com — Wed, 17 Feb 2010 07:00:00 +0100

Conclusion with Jonathan Landsman / Mike Adams8:15 - 9:00 p.m. Photo ops, book signings and chatting with the Health Ranger and Jonathan LandsmanSaturday, March 20 (8am - 5pm PST)8:00 - 9:00 a.m. Welcome / Reception9:00 - 10:00 a.m. Keynote Address - Mike Adams "Unleash Your Inner Healer"10:00 - 10:30 a.m. Q&A Session with Mike Adams10:30 - 11:30 a.m. Charlotte Gerson - "Curing the Incurables"11:30 - Noon p.m. Q&A Session with Charlotte GersonNoon - 1 p.m. Lunch Break with prepared food/fresh juice for sale (or bring your own)1:00 - 2:00 p.m. Dr. Whitaker, M.D. - "Diabetes and Heart Disease: The Good, the Bad, and the Ugly"2:00 - 2:30 p.m. Q&A Session with Dr. Whitaker 2:30 - 3:00 p.m. Jay Kordich - "All Juiced Up - The Juice Daddy Speaks Out"3:00 - 3:15 p.m. Q&A Session with "The Juice Da...

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Dispatch: OEHHA and BPA, Troy on Vaccines, Aspirin and Breast Cancer, Statins and Diabetes

Health Facts and Fears — Wed, 17 Feb 2010 05:00:00 +0100

California& rsquo;s Office of Environmental Health Hazard Assessment (OEHHA) is requesting information on BPA so that they can decide if it should be added to the state& rsquo;s Prop 65 list of toxic substances... (Source: Health Facts and Fears)

Merck: Studies show Gardasil vaccine protects older women, gay men from genital cancers, warts

OrlandoSentinel: Medical Research — Wed, 17 Feb 2010 04:02:00 +0100

TRENTON, N.J. (AP) — The Gardasil vaccine protected most young women from cervical cancer and homosexual men from anal cancer, according to new studies released Wednesday by its maker, Merck & Co. The vaccine is designed to block four of the most... (Source: OrlandoSentinel: Medical Research)

New approach to treating inoperable pancreatic cancer being studied

OrlandoSentinel: Medical Research — Wed, 17 Feb 2010 00:00:00 +0100

A novel approach to treating inoperable pancreatic cancer is under study at the Cancer Institute of New Jersey, using a vaccine injected directly into the tumor. Research with mice has shown that when a vaccine is administered in the usual way, via a... (Source: OrlandoSentinel: Medical Research)

Merck: Studies show Gardasil vaccine protects older women, gay men from genital cancers, warts

OrlandoSentinel: Medical Research — Tue, 16 Feb 2010 21:06:00 +0100

WHITEHOUSE STATION, N.J. (AP) — New studies show that Merck's Gardasil vaccine protects most young women from cervical cancer and homosexual men from anal cancer. The vaccine is designed to block four of the most common strains of the sexually... (Source: OrlandoSentinel: Medical Research)

Benefit Of HPV Vaccination, Frequent Screening For Women Over 41 Is Likely To Be Low

Health News from Medical News Today — Tue, 16 Feb 2010 10:00:00 +0100

The overall potential benefits of human papillomavirus (HPV) vaccinations or frequent HPV screenings for women over the age of 41 are low, concludes a new study published online February 15 in the Journal of the National Cancer Institute. The study found that the rate of new infections preventable by vaccination declines with age. Furthermore, new infections among women at any age typically do not progress to cervical intraepithelial neoplasia grade 2 (CIN 2) or CIN 3, the precursors for cervical cancer... (Source: Health News from Medical News Today)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

UNC Leads Initiative To Eradicate Cervical Cancer; N.C. Governor Applauds Plan

Health News from Medical News Today — Tue, 16 Feb 2010 09:00:00 +0100

Asserting that no one should die from cervical cancer, public health researchers at the University of North Carolina at Chapel Hill are leading a multi-state initiative to prevent or even eradicate the disease. The Cervical Cancer-Free Initiative is a multi-year project aimed at preventing the disease through vaccination against human papillomavirus (HPV) and effective screening for early signs of cervical cancer. Initial funding for the initiative is through a $1.5 million unrestricted educational grant to the UNC Gillings School of Global Public Health by GlaxoSmithKline... (Source: Health News from Medical News Today)

The "Secret Weapon" Of Retroviruses That Cause Cancer

Immune System / Vaccines News From Medical News Today — Tue, 16 Feb 2010 09:00:00 +0100

Oncogenic retroviruses are a particular family of viruses that can cause some types of cancer. Thierry Heidmann and his colleagues in the CNRS-Institut Gustave Roussy-Universite Paris Sud 11 "RÃ©trovirus endogÃ¨nes et elements retroides des eucaryotes superieurs" Laboratory have studied these viruses... (Source: Immune System / Vaccines News From Medical News Today)

UNC Leads Initiative To Eradicate Cervical Cancer; N.C. Governor Applauds Plan

Public Health News From Medical News Today — Tue, 16 Feb 2010 09:00:00 +0100

Cancer Research UK and immatics Biotechnologies to trial vaccine for brain cancer

Clinical Trials And Noteworthy Treatments For Brain Tumors — Tue, 16 Feb 2010 08:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

Cancer Research UK and immatics Biotechnologies to trial vaccine for brain cancer

Clinical Trials And Noteworthy Treatments For Brain Tumors — Tue, 16 Feb 2010 08:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Cancer Research UK and immatics Biotechnologies to trial vaccine for brain cancer

Clinical Trials And Noteworthy Treatments For Brain Tumors — Tue, 16 Feb 2010 08:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

Cancer Research UK and immatics Biotechnologies to trial vaccine for brain cancer

Clinical Trials And Noteworthy Treatments For Brain Tumors — Tue, 16 Feb 2010 08:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

Cancer Research UK and immatics Biotechnologies to trial vaccine for brain cancer

Clinical Trials And Noteworthy Treatments For Brain Tumors — Tue, 16 Feb 2010 08:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

Cancer Research UK and immatics Biotechnologies to trial vaccine for brain cancer

Clinical Trials And Noteworthy Treatments For Brain Tumors — Tue, 16 Feb 2010 08:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

Cancer Research UK and immatics Biotechnologies to trial vaccine for brain cancer

Clinical Trials And Noteworthy Treatments For Brain Tumors — Tue, 16 Feb 2010 08:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Cancer Research UK and immatics Biotechnologies to trial vaccine for brain cancer

Clinical Trials And Noteworthy Treatments For Brain Tumors — Tue, 16 Feb 2010 08:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

Cancer Research UK and immatics Biotechnologies to trial vaccine for brain cancer

Clinical Trials And Noteworthy Treatments For Brain Tumors — Tue, 16 Feb 2010 08:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

Cancer Research UK and immatics Biotechnologies to trial vaccine for brain cancer

Clinical Trials And Noteworthy Treatments For Brain Tumors — Tue, 16 Feb 2010 08:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

Cancer Research UK and immatics Biotechnologies to trial vaccine for brain cancer

Clinical Trials And Noteworthy Treatments For Brain Tumors — Tue, 16 Feb 2010 08:12:00 +0100

(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)

HPV vaccine programme to be deferred to September

The Irish Times - Health — Tue, 16 Feb 2010 00:05:57 +0100

Cervical cancer vaccination will be available for girls already in first year and for those entering secondary school, writesMUIRIS HOUSTON (Source: The Irish Times - Health)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Badly fitting condoms a turn off and infection risk

OnMedica Latest News — Tue, 16 Feb 2010 00:00:00 +0100

Ill-fitting condoms over twice as likely to slip or break survey findsRelated items from OnMedicaStudy says many women 'not on safest pill'Consistency plea in prostate cancer studiesNew HPV cancer vaccine has worldwide potentialMassive rise in demand for NHS DirectNational Pandemic Service to stand down as swine flu declines (Source: OnMedica Latest News)

Immunisation practices of paediatric oncology and shared care oncology consultants: A United Kingdom survey

Pediatric Blood and Cancer — Tue, 16 Feb 2010 00:00:00 +0100

In March 2002, the Royal College of Paediatrics and Child Health (RCPCH) introduced guidelines for re-immunisation of children after completion of standard-dose chemotherapy and after haematopoietic stem cell transplant (HSCT).To ascertain whether these guidelines form standard unit policy by undertaking a survey of UK paediatric principal treatment centre (PTC) consultants and shared care (SC) consultants.In October 2008, a link to an on-line anonymised survey was sent by e-mail to all UK PTC consultants in Children's Cancer and Leukaemia Group (CCLG) centres and to SC consultants linked to eight of these centres.Responses were received from 55 PTC consultants (representing all 21 CCLG centres) and 54 SC consultants. In accordance with the RCPCH guidelines, most PTC and SC consultants rec...

Gene Therapy for Mesothelioma and Lung Cancer.

Am J Respir Cell Mol... — Tue, 16 Feb 2010 00:00:00 +0100

Authors: Vachani A, Moon E, Wakeam E, Albelda SM Both malignant pleural mesothelioma and advanced stage lung cancer are associated with a poor prognosis. Unfortunately, current treatment regimens have had only a modest effect on their progressive course. Gene therapy for thoracic malignancies represents a novel therapeutic approach and has been evaluated in a number of clinical trials over the last two decades. Using viral vectors or anti-sense RNA, strategies have included induction of apoptosis, tumor suppressor gene replacement, suicide gene expression, cytokine-based therapy, various vaccination approaches, and adoptive transfer of modified immune cells. This review will consider the clinical results, limitations, and future directions of gene therapy trials for thoracic malignanci...

Tobacco Use Linked To Worse Outcomes In HPV-Positive Head And Neck Cancer, U-M Study Finds

Cancer / Oncology News From Medical News Today — Mon, 15 Feb 2010 10:00:00 +0100

Patients with head and neck cancer linked to high risk human papillomavirus, or HPV, have worse outcomes if they are current or former tobacco users, according to a new study from researchers at the University of Michigan Comprehensive Cancer Center. High-risk HPVs are the same viruses that are associated with cancers of the uterine cervix... (Source: Cancer / Oncology News From Medical News Today)

Tobacco Use Linked To Worse Outcomes In HPV-Positive Head And Neck Cancer, U-M Study Finds

Health News from Medical News Today — Mon, 15 Feb 2010 10:00:00 +0100

Patients with head and neck cancer linked to high risk human papillomavirus, or HPV, have worse outcomes if they are current or former tobacco users, according to a new study from researchers at the University of Michigan Comprehensive Cancer Center. High-risk HPVs are the same viruses that are associated with cancers of the uterine cervix. The research suggests that current or former tobacco users may need a more aggressive treatment regimen than patients who have never used tobacco... (Source: Health News from Medical News Today)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Thirty-six predictions for the world: 2010 - 2012

NaturalNews.com — Mon, 15 Feb 2010 07:00:00 +0100

This article isn't the place to detail what's involved in that, but know that despite all the predictions I've listed here, I'm an optimist! I believe the world will go through a very difficult time in the next decade (or more), but We the People will emerge stronger, more resourceful, more humbled and with a sense of renewed freedom in creating whatever future we desire.I will continue to bring you news and information as we face the coming challenges and emerge from it on the other side. Join me here on NaturalNews.com for news and updates on all the issues that matter to us in creating a brighter, more sustainable world for our collective future.The future is nothing to be feared. The rise and fall of nations is a normal, natural cycle that's been observed throughout world history. The ...

Dendritic Cell-Derived Exosomes for Cancer Immunotherapy: What's Next?

Cancer Research — Mon, 15 Feb 2010 05:08:30 +0100

Exosomes are nanovesicles originating from late endosomal compartments and secreted by most living cells in ex vivo cell culture conditions. The interest in exosomes was rekindled when B-cell and dendritic cell-derived exosomes were shown to mediate MHC-dependent immune responses. Despite limited understanding of exosome biogenesis and physiological relevance, accumulating evidence points to their bioactivity culminating in clinical applications in cancer. This review focuses on the preclinical studies exploiting the immunogenicity of dendritic cell-derived exosomes (Dex) and will elaborate on the past and future vaccination trials conducted using Dex strategy in melanoma and non-small cell lung cancer patients. Cancer Res; 70(4); 1281–5 (Source: Cancer Research)

News brief: Benefit of HPV Vaccination, Frequent Screening for Women over 41 is Likely to be Low

EurekAlert! - Medicine and Health — Mon, 15 Feb 2010 05:00:00 +0100

(Journal of the National Cancer Institute) The overall potential benefits of human papillomavirus (HPV) vaccinations or frequent HPV screenings for women over the age of 41 are low, concludes a new study published online February 15 in the Journal of the National Cancer Institute. The study found that the rate of new infections preventable by vaccination declines with age. Furthermore, new infections among women at any age typically do not progress to cervical intraepithelial neoplasia grade 2 (CIN 2) or CIN 3, the precursors for cervical cancer. (Source: EurekAlert! - Medicine and Health)

New strategy produces promising advance in cancer vaccines

EurekAlert! - Medicine and Health — Mon, 15 Feb 2010 05:00:00 +0100

(National Jewish Medical and Research Center) Researchers at National Jewish Health and the University of Colorado School of Medicine have used a new strategy to develop cancer vaccines that are remarkably effective in mice. Kimberly Jordan, Jill Slansky, and John Kappler, report that 100 percent of the mice vaccinated with a peptide they developed remained alive and tumor-free for at least 60 days after inoculation with colon cancer cells. The research suggests a method for developing vaccines against a wide variety of cancers. (Source: EurekAlert! - Medicine and Health)

IOM Urges Hepatitis Screening, Prevention

Internal Medicine News — Mon, 15 Feb 2010 00:00:00 +0100

The Institute of Medicine is calling for increased awareness of hepatitis B and C among health care providers, social service providers, and at-risk communities as well as better surveillance and more stringent vaccination requirements nationwide in its newly released report on hepatitis and liver cancer. (Source: Internal Medicine News)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

CD4+ T Cell Epitope Discovery and Rational Vaccine Design

Archivum Immunologiae et Therapiae Experimentalis — Sun, 14 Feb 2010 06:52:07 +0100

Abstract T cell epitope-driven vaccine design employs bioinformatic algorithms to identify potential targets of vaccines against infectious diseases or cancer. Potential epitopes can be identified with major histocompatibility complex (MHC)-binding algorithms, and the ability to bind to MHC class I or class II indicates a predominantly CD4+ or CD8+ T cell response. Furthermore, an epitope-based vaccine can circumvent evolutionary events favoring immune escape present in native proteins from pathogens. It can also focus on only the most relevant epitopes (i.e. conserved and promiscuous) recognized by the majority of the target population. Mounting evidence points to the critical role of CD4+ T cells in natural antigen encounter and active immunization. In this paper the need ...

Drivers and barriers to acceptance of human-papillomavirus vaccination among young women: a qualitative and quantitative study

BMC Public Health - Latest articles — Sun, 14 Feb 2010 00:00:00 +0100

Conclusion: The difference between intention to be vaccinated and starting vaccination was considerable, and a large proportion of women aged 16-26 did not wish to be vaccinated. If the most important barriers to vaccination were addressed (cost and a lack of information about vaccination benefits), it is likely that the uptake of vaccination in Denmark would increase substantially. (Source: BMC Public Health - Latest articles)

Helix BioPharma Announces Positive Interim Results From Its Ongoing Phase II Pharmacokinetic Clinical Study Of Topical Interferon Alpha-2b

Health News from Medical News Today — Sat, 13 Feb 2010 09:00:00 +0100

Helix BioPharma Corp. (TSX, FSE: HBP; Pink Sheets: HXBPF) announced that the first ten patients that have been enrolled in its Phase II pharmacokinetic study of Topical Interferon Alpha-2b in patients with low-grade cervical lesions have completed the pharmacokinetic primary endpoint analyses with positive findings. All ten of these patients, at all sampling time points, were found to have systemic interferon alpha-2b levels below the lower limit of detection (6.25 pg/mL) of the validated bioassay used in the study... (Source: Health News from Medical News Today)

Helix BioPharma Announces Positive Interim Results From Its Ongoing Phase II Pharmacokinetic Clinical Study Of Topical Interferon Alpha-2b

Women's Health / OBGYN News From Medical News Today — Sat, 13 Feb 2010 09:00:00 +0100

Pluripotent stem cells as source of dendritic cells for immune therapy.

International Journal of Hematology — Sat, 13 Feb 2010 00:00:00 +0100

Authors: Senju S, Hirata S, Motomura Y, Fukuma D, Matsunaga Y, Fukushima S, Matsuyoshi H, Nishimura Y Dendritic cells (DC) are the most potent antigen-presenting cells. In vivo transfer of antigen-bearing DC has proven efficient in priming T cell responses specific to the antigen. DC-based cellular vaccination is now regarded as a powerful means for immunotherapy, especially for anti-cancer immunotherapy. Clinical trials of therapy with DC pulsed with peptide antigens or genetically modified to present antigens are currently carried out in many institutions. In addition, antigen-specific negative regulation of immune response by DC is considered to be a promising approach for treatments of autoimmune diseases and also for regulation of allo-reactive immune response causing graft reject...

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Heal yourself in 15 days: Stop making disease by embracing the recipe for health

NaturalNews.com — Fri, 12 Feb 2010 07:00:00 +0100

(NaturalNews) It also seems too simple: In order to achieve lasting health, simply stop making disease. But the concept is foreign to most people: Making disease? Why would I be making disease?Mainstream consumers, you see, have been trained by the medical industry to believe that disease strikes spontaneously, without any real cause. One day you have nothing wrong with you, and then suddenly the next day you're diagnosed with a breast cancer tumor. Shazam! It happens just like being struck by lightning... (and it's not your fault, you're told -- there's nothing you could have done about it...)That's what they want you to believe, anyway. But the truth is very different: All the most common degenerative diseases -- cancer, diabetes, heart disease, Alzheimer's, etc. -- take many years to gr...

3-D structure of bullet-shaped virus with potential to fight cancer, HIV revealed

ScienceDaily Headlines — Thu, 11 Feb 2010 22:00:00 +0100

A recent study demonstrates that with advanced imaging technique, the vesicular stomatitis virus can be modified to serve as an anti-cancer agent because it displays high selectivity in killing cancer cells while sparing normal cells. It can also be engineered as a potent vaccine against HIV/AIDS. (Source: ScienceDaily Headlines)

Direct Injection Vaccine Combo Tested For Pancreas Cancer

Health News from Medical News Today — Thu, 11 Feb 2010 11:00:00 +0100

More than 42,500 people in the United States were diagnosed with pancreatic cancer last year and nearly 35,200 died from the disease, according to The American Cancer Society. The lifetime risk of developing pancreatic cancer is about one in 76 for both men and women and there is a five-year survival rate of only five percent, despite advancements in surgery, chemotherapy and radiation treatment... (Source: Health News from Medical News Today)

Direct Injection Vaccine Combo Tested For Pancreas Cancer

Immune System / Vaccines News From Medical News Today — Thu, 11 Feb 2010 11:00:00 +0100

Blocking Cell Movement For Cancer, MS Treatment

Immune System / Vaccines News From Medical News Today — Thu, 11 Feb 2010 09:00:00 +0100

University of Adelaide researchers in Australia are finding new ways to block the movement of cells in the body which can cause autoimmune diseases and the spread of cancer. Led by Professor of Immunology Shaun McColl, the researchers have identified molecular "receptors" on the surface of cells which are involved in helping cells migrate to sites where they can cause disease... (Source: Immune System / Vaccines News From Medical News Today)

MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.

Seeking A Vaccine For Helicobacter pylori In Chilean Patients

Health News from Medical News Today — Thu, 11 Feb 2010 08:00:00 +0100

Helicobacter pylori (H. pylori) is the causal agent of chronic gastritis, ulcer and gastric cancer. It has the potential to persist in the human stomach for decades, sometimes causing neither harm nor clinical symptoms. Nevertheless, on some occasions, depending on the host immune system and the strain causing the infection, the outcome can be very serious. To maintain the infection, the bacterium must adapt to survive the host defences. One way to accomplish this is to sequentially change the external proteins on the bacterial surface... (Source: Health News from Medical News Today)

Regimen With New Drug Triapine Provides Both Significant Reduction And Control In Cervical Cancer

Health News from Medical News Today — Thu, 11 Feb 2010 08:00:00 +0100

Researchers at the Ireland Cancer Center of University Hospitals (UH) Case Medical Center, have published new findings that may lead to a new standard of care for patients with locally advanced cervical cancer. Published in the February issue of Clinical Cancer Research, the phase one study found that a new chemotherapy medicine, Triapine, was well tolerated in combination with standard-of-care cisplatin chemotherapy and radiation treatment in women with cervical cancer. This regimen provided both significant reduction in cancer disease and cancer control... (Source: Health News from Medical News Today)

Researchers Reveal 3-D Structure Of Bullet-Shaped Virus With Potential To Fight Cancer, HIV

Health News from Medical News Today — Thu, 11 Feb 2010 08:00:00 +0100

Vesicular stomatitis virus, or VSV, has long been a model system for studying and understanding the life cycle of negative-strand RNA viruses, which include viruses that cause influenza, measles and rabies. More importantly, research has shown that VSV has the potential to be genetically modified to serve as an anti-cancer agent, exercising high selectivity in killing cancer cells while sparing healthy cells, and as a potent vaccine against HIV. For such modifications to occur, however, scientists must have an accurate picture of the virus's structure... (Source: Health News from Medical News Today)

Seeking A Vaccine For Helicobacter pylori In Chilean Patients

Immune System / Vaccines News From Medical News Today — Thu, 11 Feb 2010 08:00:00 +0100

Helicobacter pylori (H. pylori) is the causal agent of chronic gastritis, ulcer and gastric cancer. It has the potential to persist in the human stomach for decades, sometimes causing neither harm nor clinical symptoms. Nevertheless, on some occasions, depending on the host immune system and the strain causing the infection, the outcome can be very serious... (Source: Immune System / Vaccines News From Medical News Today)