MedWorm: HIB Vaccine

“Paranoia Strikes Deep”*: MMR Vaccine and Autism

Psychiatric Times — Wed, 03 Mar 2010 12:00:00 +0100

On February 12, 2009, the US Court of Federal Claims issued a trio of long-awaited decisions in its Omnibus Autism Proceeding. The 3 were representative cases chosen from more than 5500 pending MMR/autism cases by the Plaintiffs’ Steering Committee. Each presented the theory that the measles-mumps-rubella (MMR) vaccine in combination with thimerosal, a mercury-based ingredient contained in some diphtheria-tetanus-pertussis (DTP), diphtheria-tetanus–acellular pertussis (DTaP), hepatitis B, and Haemophilus influenzae type B (Hib) vaccines, causes autism. In nearly 700 combined pages that reviewed the scientific and epidemiological evidence, all 3 opinions determined that the plaintiffs had not demonstrated a link between these vaccines and autism. (Source: Psychiatric Times)

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Invasive Haemophilus influenzae Disease, Europe, 1996-2006.

Emerging Infectious Diseases — Mon, 01 Mar 2010 00:00:00 +0100

Authors: Ladhani S, Slack MP, Heath PT, von Gottberg A, Chandra M, Ramsay ME, An international collaboration was established in 1996 to monitor the impact of routine Haemophilus influenzae type b (Hib) vaccination on invasive H. influenzae disease; 14 countries routinely serotype all clinical isolates. Of the 10,081 invasive H. influenzae infections reported during 1996-2006, 4,466 (44%, incidence 0.28 infections/100,000 population) were due to noncapsulated H. influenzae (ncHi); 2,836 (28%, 0.15/100,000), to Hib; and 690 (7%, 0.036/100,000), to non-b encapsulated H. influenzae. Invasive ncHi infections occurred in older persons more often than Hib (median age 58 years vs. 5 years, p<0.0001) and were associated with higher case-fatality ratios (12% vs. 4%, p<0.0001), particularl...

Surveillance for adverse events after DTwP/Hib vaccination in Brazil: Sensitivity and factors associated with reporting.

Vaccine — Sat, 27 Feb 2010 00:00:00 +0100

Authors: Monteiro SA, Takano OA, Waldman EA We estimated the sensitivity, i.e., the proportion of all cases of adverse events following immunization (AEFIs) reported to the Brazilian passive surveillance for adverse events following immunization (PSAEFI) with the diphtheria-tetanus-whole-cell pertussis-Haemophilus influenzae type b (DTwP/Hib) vaccine, as well as investigating factors associated with AEFIs reporting. During 2003-2004, 8303 AEFIs associated with DTwP-Hib were reported; hypotonic-hyporesponsive episodes (HHEs), fever and convulsions being the most common. Cure without sequel was achieved in 98.4% of the cases. The mean sensitivity of the PSAEFI was 22.3% and 31.6%, respectively, for HHE and convulsions, varying widely among states. Reporting rates correlated positively wi...

Hib vaccine shortage over; recall patients for booster shot [NEWS AND FEATURES]

AAP News — Fri, 26 Feb 2010 18:01:27 +0100

(Source: AAP News)

Presence of multiple copies of capsulation loci in invasive Haemophilus influenzae type b (Hib) strains in Japan before introduction of the Hib conjugate vaccine

Microbiology and Immunology — Thu, 25 Feb 2010 00:00:00 +0100

We examined 24 Hib strains from Japanese children with invasive diseases due to Hib. Although all strains showed the same capb sequence, Southern blot analysis showed that four strains (16.7%) harbored multiple copies (more than two) of the capb locus. Careful analysis of the locus in circulating Hib strains is necessary now that the Hib vaccine has been introduced into Japan. (Source: Microbiology and Immunology)

Challenge with hepatitis B vaccine in children previously vaccinated with a hepatitis B-containing combination vaccine.

Advances in Therapy — Thu, 25 Feb 2010 00:00:00 +0100

CONCLUSION: Vaccination with a HBV-containing multivalent vaccine during infancy induces a lasting immune memory that can be boosted, even in children with a decline in anti-HBs concentrations. The present results confirm that the full primary vaccination schedule in infancy seems to confer long-term protection via immune memory and that an additional HBV dose is not generally required. PMID: 20182924 [PubMed - as supplied by publisher] (Source: Advances in Therapy)

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DTP-poliovirus vaccine/Hib-DTP-poliovirus vaccine/Hib vaccine: Platelet disorder in an infant: case report

Reactions — Mon, 22 Feb 2010 14:16:47 +0100

(Source: Reactions)

Merck Resumes Distribution of Monovalent Hib Vaccine

AAFP Clinical Care and Research — Fri, 12 Feb 2010 21:10:00 +0100

Merck & Co. Inc. has announced that PedvaxHIB, the manufacturer's monovalent Haemophilus influenzae type b, or Hib, conjugate vaccine is back on the market after an absence of more than two years. (Source: AAFP Clinical Care and Research)

Hib vaccine/meningococcal vaccine: Dermatolipomyonecrosis: case report

Reactions — Tue, 19 Jan 2010 14:09:29 +0100

(Source: Reactions)

Licensure of a Haemophilus influenzae Type b (Hib) Vaccine (Hiberix) and Updated Recommendations for Use of Hib Vaccine

Medscape Today Headlines — Mon, 18 Jan 2010 12:04:49 +0100

The recent shortage of Hib vaccines has left many children in need of catch-up vaccination. With vaccine supplies increasing, now is the time to recall those children in need, according to the CDC. Morbidity & Mortality Weekly Report (Source: Medscape Today Headlines)

Safety assessment of recalled Haemophilus influenzae type b (Hib) conjugate vaccines - United States, 2007-2008

Pharmacoepidemiology and Drug Safety — Mon, 18 Jan 2010 00:00:00 +0100

On 13 December 2007, Merck & Co., Inc. voluntarily recalled 1.2 million doses of Haemophilus influenzae type b (Hib) vaccines that had been distributed since April 2007 for concerns regarding potential Bacillus cereus contamination. Enhanced postrecall surveillance was conducted to detect vaccine-associated B. cereus infections.We reviewed reports involving recalled Hib vaccines received by the Vaccine Adverse Event Reporting System (VAERS) during 1 April 2007-29 February 2008. For each reported death, autopsy review sought evidence of B. cereus infections. For each specified outcome, the proportional reporting ratios (PRRs) were calculated to compare the recalled Hib vaccines with the manufacturer's nonrecalled Hib vaccines in the VAERS databases. On 20 December 2007, we used the Epidemic...

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Lasting immune memory against hepatitis B in children after primary immunization with 4 doses of DTPa-HBV-IPV/Hib in the first and 2nd year of life

BMC Infectious Diseases — Fri, 15 Jan 2010 00:00:00 +0100

Background: Few studies have assessed long term persisting immunity against hepatitis B virus (HBV) in children vaccinated during infancy with combined vaccines containing recombinant HBV surface antigen (HBs). We assessed antibody persistence and immune memory in children 4-5 years of age, previously vaccinated with four doses of combined hexavalent DTPa-HBV-IPV/Hib vaccine (Infanrix hexaTM). Methods: Immune memory was assessed in 301 children through administration of a challenge dose of monovalent HBV vaccine. Results: At 4-5 years of age, 85.3% of subjects had persisting anti-HBs antibody concentrations [greater than or equal to]10 mIU/mL, rising to 98.6% after the HBV challenge dose. All but 12 subjects (95.8%) achieved post-challenge anti-HBs concentrations [greater than or equal to]...

Long-term complications and risk of other serious infections following invasive Haemophilus influenzae serotype b disease in vaccinated children.

Vaccine — Mon, 04 Jan 2010 00:00:00 +0100

This study describes the long-term complications in children with Haemophilus influenzae serotype b (Hib) vaccine failure and to determine their risk of other serious infections. The families of children with invasive Hib disease after appropriate vaccination (i.e. vaccine failure) were contacted to complete a questionnaire relating to their health. Overall, 323 families were contacted and 260 (80.5%) completed the questionnaire. Of the 124 children with meningitis, 18.5% reported serious long-term sequelae and a further 12% of parents attributed other problems to Hib meningitis. Forty-nine children (18.9%) had at least one other episode of serious infection requiring hospital admission and 7.7% had at least two serious infections. In a Poisson regression model, the risk of another serious...

The immunogenicity of a heptavalent conjugate pneumococcal vaccine concurrently administered with a combination DTaP/IPV/Hib vaccine and a meningococcal group C conjugate vaccine at 2, 3 and 4 months of age.

Clinical and Vaccine Immunology — Wed, 30 Dec 2009 00:00:00 +0100

In conclusion when vaccinated according to this schedule infants had lower post-primary immunisation responses to Hib, MCC and pneumococcal serotype 6B than demonstrated with other schedules. Despite this there was a good response following a 4(th) dose of PCV7. PMID: 20042517 [PubMed - as supplied by publisher] (Source: Clinical and Vaccine Immunology)

Characterization of nontypeable Haemophilus influenzae collected from respiratory infections and invasive disease cases in Manitoba, Canada

FEMS Immunology and Medical Microbiology — Wed, 23 Dec 2009 00:00:00 +0100

With the introduction of the Haemophilus influenzae serotype b (Hib) vaccine, invasive Hib disease has decreased substantially, but nontypeable H. influenzae (NT Hi) disease appears to be increasing. In order to understand the origin of NT Hi strains and their relationship with serotypeable strains, we analysed 125 NT Hi isolates collected from individual patients with either invasive disease (70 isolates) or respiratory tract infections (55 isolates). Serotype-specific and capsular transport genes were absent by PCR analysis, confirming their nonencapsulated status, which also suggested the NT Hi isolates were not encapsulated strains that shed their capsules. Multilocus sequence typing confirmed the NT Hi isolates did not have the same genetic background as serotypeable strains, includin...

Children With Persistent AOM Have Poor Immune Responses to Pneumococcal and HiB Vaccines

Medscape Today Headlines — Wed, 02 Dec 2009 19:07:51 +0100

Children with recurrent ear infections have a poor immunogenic response to pneumococcal-7 and Hemophilus influenza B vaccines; only 13% appear to be fully immunized against Streptococcal pneumonia. Medscape Medical News (Source: Medscape Today Headlines)

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Vaccines: Hyperhaemolysis (first reports with meningococcal vaccine groups A C Y W-135 polysaccharide and Hib vaccine conjugate) in an EBV-infected patient: case report

Reactions — Mon, 16 Nov 2009 14:06:44 +0100

(Source: Reactions)

Pattern of functional antibody activity against Haemophilus influenzae type b (Hib) in infants immunized with diphtheria-tetanus-pertussis/Hib Brazilian combination vaccine.

Braz J Med Biol Res — Fri, 06 Nov 2009 00:00:00 +0100

Authors: Matos DC, Silva AM, Neves PC, Martins RM, Homma A, Marcovistz R We evaluated the functional activity of Haemophilus influenzae B (Hib) antibodies elicited in a group of infants immunized with the diphtheria-tetanus-pertussis vaccine combined with an Hib vaccine produced totally in Brazil after technological transfer of Hib vaccine production from Glaxo SmithKline, Belgium. Blood samples from immunized infants (N = 985) were collected for the determination of Hib antibodies. Total Ig and IgM and IgG subclasses of antibodies against polyribosyl ribitol phosphate (PRP) were analyzed by ELISA. Almost all vaccinees (97.56%, 961/985) developed a strong anti-PRP IgG antibody response (>/=1.0 mug/mL), while an anti-PRP IgM response was observed in 64.24% (634/985) of them (>/=0....

Haemophilus influenzae serotype b conjugate vaccine failure in twelve countries with established national childhood immunization programmes

Clinical Microbiology and Infection — Thu, 05 Nov 2009 00:00:00 +0100

Clin Microbiol Infect The present study describes the clinical and immunological features of children with Hib vaccine failure, who were identified through national surveillance between 1996 and 2001 in Europe, Israel and Australia. True vaccine failure was defined as invasive Hib disease occurring [ge]2 weeks after one dose, given after the first birthday, or [ge]1 week after [ge]2 doses, given at (Source: Clinical Microbiology and Infection)

NTAGI Subcommittee Recommendations on Haemophilus influenzae Type b (Hib) Vaccine Introduction in India.

Indian Pediatrics — Sun, 01 Nov 2009 00:00:00 +0100

Authors: , Kant L Background: WHO estimates that Haemophilus influenzae type b (Hib) caused over 8 million cases of serious disease and 376,000 deaths globally in the year 2000. The introduction of Hib vaccines has essentially eliminated Hib disease in countries where they are routinely used. Now, almost all Hib disease cases and deaths occur in countries where Hib vaccines is not incorporated in the routine immunization program. Process: The Hib and Pneumococcal subcommittee of National Technical Advisory Group on Immunization (NTAGI) in India met in April 2008. This paper focuses on the discussions regarding Hib vaccine introduction; the pneumococcal vaccine discussion is being published separately. The subcommittee reviewed the available published and unpublished literature as well...

Hib vaccine conjugate: Lack of efficacy in a child, leading to Hib epiglottitis: case report

Reactions — Mon, 26 Oct 2009 14:08:49 +0100

(Source: Reactions)

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Effect of probiotic supplementation on immunoglobulins, isoagglutinins and antibody response in children of low socio-economic status

European Journal of Nutrition — Fri, 16 Oct 2009 17:54:13 +0100

Conclusions Supplementation of standard fermented milk with additional probiotics was not of benefit. The high natural rate of early microbial exposure in infants and children from a population of low socio-economic status living in a “less hygienic environment” may account for the absence of an additional immune-stimulating effect by supplementary probiotics. Content Type Journal ArticleCategory Original ContributionDOI 10.1007/s00394-009-0063-5Authors Néstor Pérez, Hospital de Niños de La Plata, Comisión de Investigaciones Científicas de la Provincia de Buenos Aires (CICPBA) Unidad de Inmunología S.M. Ludovica, 14 y 65 La Plata 1900 ArgentinaJuan C. Iannicelli, Hospital de Niños de La Plata, Comisión de Investigaciones Científicas de la Provincia de Bue...

South Asia News in brief: 2–14 October 2009

SciDev.Net — Wed, 14 Oct 2009 03:26:46 +0100

Scientists produce biofuel from water hyacinths, global climate models adjusted for local use, Bhutan to introduce Hib vaccine, and more. (Source: SciDev.Net)

CDC, AAFP Recommending Recall of Children in Need of Hib Booster Dose

AAFP Health of the Public — Mon, 28 Sep 2009 21:55:00 +0100

As the nation's supply of Haemophilus influenzae type b, or Hib, vaccine increases thanks to the FDA's August approval of GlaxoSmithKline's Hiberix as a booster dose for children ages 15 months to 4 years, the AAFP has adopted the CDC's recommendation that physicians recall children who have not received a booster dose. (Source: AAFP Health of the Public)

Licensure of a Haemophilus influenzae type b (Hib) vaccine (Hiberix) and updated recommendations for use of Hib vaccine.

MMWR Morb Mortal Wkl... — Thu, 17 Sep 2009 23:00:00 +0100

This report summarizes the indications for Hiberix use and provides guidance on Hib booster dose administration based on increasing vaccine supplies. Vaccination recommendations in this report update the previous advisory on Hib booster administration (June 26, 2009), which advised that children with deferred booster doses receive it at the next regularly scheduled visit. Vaccination providers are now recommended to begin recall of children in need of the booster dose when feasible and monovalent Hib vaccine supply in the office is adequate. PMID: 19763078 [PubMed - indexed for MEDLINE] (Source: MMWR Morb Mortal Wkl...)

Licensure of a Haemophilus influenzae Type b (Hib) Vaccine (Hiberix) and Updated Recommendations for Use of Hib Vaccine

CDC Morbidity and Mortality Weekly Report — Thu, 17 Sep 2009 16:06:02 +0100

(Source: CDC Morbidity and Mortality Weekly Report)

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Phenotypic and genetic characterizations of nontypeable Haemophilus influenzae isolates in a hospital in Thailand

Journal of Infection — Wed, 02 Sep 2009 23:00:00 +0100

Since the introduction of the Haemophilus influenzae serotype b (Hib) vaccine, the decline in invasive Hib disease and the relative increase in nontypeable H. influenzae (NTHi) infections has been well documented in many parts of the world. In South East Asia, however, Hib disease burden is controversial and has been a matter of debate. The decision on the use of Hib vaccine thus awaits for more data on the true incidence of Hib disease. In Thailand where Hib vaccine has not been nationally introduced, H. influenzae remains one of the most important respiratory pathogens. While studies regarding the infections caused by H. influenzae in Thailand have been exclusively to Hib, the situation of NTHi infections has been limited. The present study was therefore to determine the prevalence of a...

Approved Hib Booster Vaccine Shores Up Supply

Family Practice News — Mon, 31 Aug 2009 23:00:00 +0100

The Food and Drug Administration has approved a new Haemophilus influenzae type b (Hib) vaccine for use as a booster dose in children aged 15 months through 4 years, providing another option for children whose boosters were deferred as a result of the nationwide Hib vaccine shortage that began almost 2 years ago, the agency announced last month. (Source: Family Practice News)

New Hib Booster Vaccine Shores Up Supply

Pediatric News — Mon, 31 Aug 2009 23:00:00 +0100

IgG responses after booster vaccination with different pertussis vaccines in Dutch children 4 years of age: Effect of vaccine antigen content.

Vaccine — Sun, 30 Aug 2009 23:00:00 +0100

This study shows that a booster vaccine with high pertussis antigen concentrations induces higher antibody levels than a low antigen containing vaccine. In children primed with the Dutch DTwP-IPV-Hib vaccine we suggest to administer a booster vaccine containing high pertussis antigens to optimize IgG responses. The pertussis vaccination history has to be taken into account in decisions on changes in pertussis vaccination policy. PMID: 19729085 [PubMed - as supplied by publisher] (Source: Vaccine)

No Evidence That Combined DTP-HBV-Hib Vaccine Works Better

Health Behavior News Service — Fri, 28 Aug 2009 12:24:15 +0100

07/21/2009, Cochrane Library, There is no evidence that giving infants a combination vaccine for diphtheria (D), tetanus (T), pertussis (P), hepatitis B (HBV), and Haemophilus influenza type B (Hib) protects them as effectively as separate vaccines, according to the results of a new Cochrane review. (Source: Health Behavior News Service)

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National, state, and local area vaccination coverage among children aged 19-35 months - United States, 2008.

MMWR Morb Mortal Wkl... — Thu, 27 Aug 2009 23:00:00 +0100

This report describes the 2008 NIS coverage estimates for this series and individual vaccines, 7-valent pneumococcal conjugate vaccine (PCV7), >or=2 doses of hepatitis A vaccine (HepA), and hepatitis B vaccination received in the first 3 days of life (HepB birth dose) among children born during January 2005-June 2007. In 2008, 4:3:1:3:3:1 series coverage was 76.1%, compared with 77.4% in 2007; >or=90% coverage was maintained for all recommended series vaccines, except >or=4 doses of diphtheria, tetanus, and acellular pertussis (DTaP) vaccine. Coverage with >or=3 doses of Haemophilus influenzae type b vaccine (Hib) decreased from 2007, likely because of the shortage of Hib vaccine and the recommendation to defer the routine Hib vaccine booster dose administered at age 12-15 mont...

New GSK Product Should Help Alleviate Hib Vaccine Shortage

AAFP Clinical Care and Research — Wed, 26 Aug 2009 22:20:00 +0100

The nation's supply of Haemophilus influenzae type b, or Hib, vaccine should see a much-needed upsurge in the coming weeks, thanks to the Aug. 19 FDA approval of GlaxoSmithKline's Hiberix as a booster dose for children ages 15 months to 4 years. (Source: AAFP Clinical Care and Research)

FDA Approves Glaxosmithkline's Hib Vaccine, Hiberix(R)

Health News from Medical News Today — Fri, 21 Aug 2009 08:00:00 +0100

In response to a U.S. shortage of a vaccine to protect infants from Haemophilus influenzae type b (Hib), GlaxoSmithKline (NYSE: GSK) has received accelerated approval from the FDA (Food and Drug Administration) for Hiberix® [Haemophilus b Conjugate Vaccine (Tetanus Toxoid Conjugate)] as a booster dose in children 15 months through four years of age. (Source: Health News from Medical News Today)

New Hib Vaccine Granted Accelerated Approval

MedicineNet Hepatitis C General — Fri, 21 Aug 2009 07:00:00 +0100

Title: New Hib Vaccine Granted Accelerated ApprovalCategory: Health NewsCreated: 8/20/2009 2:10:00 PMLast Editorial Review: 8/21/2009 (Source: MedicineNet Hepatitis C General)

New Hib Vaccine Granted Accelerated Approval

MedicineNet Kids Health General — Fri, 21 Aug 2009 07:00:00 +0100

Title: New Hib Vaccine Granted Accelerated ApprovalCategory: Health NewsCreated: 8/20/2009 2:10:00 PMLast Editorial Review: 8/21/2009 (Source: MedicineNet Kids Health General)

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FDA Okays Vaccine for Hib Booster

MedPage Today Infectious Disease — Thu, 20 Aug 2009 17:47:09 +0100

WASHINGTON (MedPage Today) -- The FDA has approved a new Haemophilus influenzae type b (Hib) vaccine -- Hiberix -- for use as a booster dose from age 15 months through 4 years. (Source: MedPage Today Infectious Disease)

Accelerated FDA Approval of New Hib Vaccine Boosts Nationwide Supply

Medscape Today Headlines — Thu, 20 Aug 2009 15:32:56 +0100

The FDA has granted accelerated approval for a Haemophilus influenza type b vaccine as a booster dose for children aged 15 months through 4 years. Medscape Medical News (Source: Medscape Today Headlines)

FDA Approves GSK's Hib Vaccine, Hiberix

Drugs.com - New Drug Approvals — Thu, 20 Aug 2009 13:53:07 +0100

PHILADELPHIA, Aug. 19 /PRNewswire-FirstCall/ -- In response to a U.S. shortage of a vaccine to protect infants from Haemophilus influenzae type b (Hib), GlaxoSmithKline (NYSE:GSK) has received accelerated approval from the FDA (Food and Drug... (Source: Drugs.com - New Drug Approvals)

Accelerated Approval Of Hiberix To Help Sustain Adequate Vaccine Supply

Health News from Medical News Today — Thu, 20 Aug 2009 11:00:00 +0100

The U.S. Food and Drug Administration approved Hiberix, a Haemophilus influenzae Type b (Hib) vaccine, as a booster dose for children 15 months through 4 years old. Hiberix is manufactured by GlaxoSmithKline, with U.S. headquarters in Research Triangle Park, N.C. and Philadelphia. (Source: Health News from Medical News Today)

Accelerated Approval of Hiberix to Help Sustain Adequate Vaccine Supply

Food and Drug Administration — Wed, 19 Aug 2009 22:10:00 +0100

The U.S. Food and Drug Administration today approved Hiberix, a Haemophilus influenzae Type b (Hib) vaccine, as a booster dose for children 15 months through 4 years old. Hiberix is manufactured by GlaxoSmithKline, with U.S. headquarters in Research Triangle Park, N.C. and Philadelphia. (Source: Food and Drug Administration)

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Jury out on Added Benefit of Combined DTP-HBV-HIB Vaccine

Medscape Today Headlines — Thu, 06 Aug 2009 15:54:46 +0100

It is unclear whether the combined diphtheria-tetanus-pertussis, hepatitis B, and Haemophilus influenzae type B (DTP-HBV-HIB) vaccine is as effective as the separate DTP-HBV and HIB vaccine, researchers say. Reuters Health Information (Source: Medscape Today Headlines)

Jury out on benefit of infant vaccine combo

Reuters: Health — Wed, 05 Aug 2009 19:41:40 +0100

NEW YORK (Reuters Health) - It is unclear whether giving infants a combination vaccine for diphtheria-tetanus-pertussis, hepatitis B, and Haemophilus influenzae type B (DTP-HBV-HIB) protects them as effectively as separate DTP-HBV and HIB vaccines, a review of published studies indicates. (Source: Reuters: Health)

Combined vs separately administered vaccines for prevention of diphtheria tetanus pertussis HBV and HIB

Gastroenterology and Liver Diseases Specialist Library - Liver — Wed, 22 Jul 2009 11:01:46 +0100

Published July 2009Plain language conclusion: Combined DTP-HBV-HIB vaccine versus separately administered DTP-HBV and HIB vaccines for prevention of diphtheria, tetanus, pertussis, hepatitis B and Haemophilus influenzae B in healthy infants up to two years of age (Source: Gastroenterology and Liver Diseases Specialist Library - Liver)

Combined vs separately administered vaccines for prevention of diphtheria tetanus pertussis HBV and HIB

Gastroenterology and Liver Diseases Specialist Library - Prevention — Wed, 22 Jul 2009 11:00:38 +0100

Combined vs separately administered vaccines for prevention of diphtheria tetanus pertussis HBV and HIB

Gastroenterology and Liver Diseases Specialist Library - Prevention — Wed, 22 Jul 2009 10:58:33 +0100

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No Evidence That Combined DTP-HBV-Hib Vaccine Works Better

Health News from Medical News Today — Wed, 22 Jul 2009 09:00:00 +0100

There is no evidence that giving infants a combination vaccine for diphtheria (D), tetanus (T), pertussis (P), hepatitis B (HBV), and Haemophilus influenza type B (Hib) protects them as effectively as separate vaccines, according to the results of a new Cochrane review. (Source: Health News from Medical News Today)

Long‐Term Immunological Follow‐Up of Children with Haemophilus influenzae Serotype b Vaccine Failure in the United Kingdom

Clinical Infectious Diseases Latest Issue — Mon, 06 Jul 2009 15:30:28 +0100

The objective of this study was to determine Hib antibody concentrations in children several years after infection and to identify risk factors for low antibody concentrations. Methods. The families of children from the United Kingdom who developed invasive Hib disease after prior immunization with Hib conjugate vaccine (i.e., Hib vaccine failure) from October 1992 through December 2005 were asked to complete a questionnaire. A blood sample was also obtained from each child. Results. Of 323 families approached, 260 (80.5%) returned a completed questionnaire, and 175 (54.2%) children provided a blood sample. The median age at follow‐up was 8.4 years (interquartile range [IQR], 6.2–15.4 years), and the median duration of follow‐up was 4.1 years (IQR, 3.5–9.7 years). Twenty‐se...

CDC Reinstates Hib Booster Dose for 12- to 15-month-olds

AAFP Clinical Care and Research — Wed, 01 Jul 2009 15:40:00 +0100

After more than a year and a half of deferrals, the booster dose of Haemophilus influenzae type b, or Hib, vaccine should again be considered a routine part of the childhood immunization schedule. The CDC -- in consultation with its Advisory Committee on Immunization Practices, or ACIP, the AAFP and the American Academy of Pediatrics -- is recommending that physicians immediately reinstate the Hib booster dose for children ages 12-15 months who have completed the three-dose primary series. (Source: AAFP Clinical Care and Research)

Hib Vaccine Booster Dose Reinstated

Pediatric News — Tue, 30 Jun 2009 23:00:00 +0100

ATLANTA — Physicians should resume giving booster vaccinations for Haemophilus influenzae type b to children aged 12–15 months at routine visits, the Centers for Disease Control and Prevention recommended. (Source: Pediatric News)

Booster HiB vaccine reinstituted in select age groups

Modern Medicine — Sun, 28 Jun 2009 23:00:00 +0100

Booster shots of a vaccine guarding against bacterial meningitis have been reinstated for children by the CDC. (Source: Modern Medicine)

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Booster HiB vaccine reinstituted in select age groups

Modern Medicine Contemporary Pediatrics — Sun, 28 Jun 2009 23:00:00 +0100

Booster shots of a vaccine guarding against bacterial meningitis have been reinstated for children by the CDC. (Source: Modern Medicine Contemporary Pediatrics)

Updated Recommendations for Use of Haemophilus influenzae Type b (Hib) Vaccine: Reinstatement of the Booster Dose at Ages 12--15 Months

CDC Morbidity and Mortality Weekly Report — Fri, 26 Jun 2009 09:46:25 +0100

(Source: CDC Morbidity and Mortality Weekly Report)

Sanofi Pasteur Responds To Nation's Need For Hib Vaccine With Increased Supply

Health News from Medical News Today — Fri, 26 Jun 2009 09:00:00 +0100

Sanofi Pasteur, the vaccines division of the sanofi-aventis Group (EURONEXT: SAN and NYSE: SNY), announced that the company has been able to increase the supply of its Hib-containing vaccines to enable the return to a full series of vaccinations for U.S. children. Based on the increased supply, on July 1, the U.S. (Source: Health News from Medical News Today)

Updated recommendations for use of Haemophilus influenzae type b (Hib) vaccine: reinstatement of the booster dose at ages 12-15 months.

MMWR Morb Mortal Wkl... — Thu, 25 Jun 2009 23:00:00 +0100

Authors: On December 13, 2007, certain lots of Haemophilus influenzae type b (Hib) vaccine marketed as PedvaxHIB (monovalent Hib vaccine) and Comvax (Hib-HepB vaccine), and manufactured by Merck & Co., Inc., were recalled voluntarily, and the company temporarily suspended production of these vaccines. To conserve the limited supply of Hib-containing vaccines, CDC, in consultation with the Advisory Committee on Immunization Practices (ACIP), the American Academy of Family Physicians (AAFP), and the American Academy of Pediatrics (AAP), on December 18, 2007, recommended that vaccination providers temporarily defer the routine Hib vaccine booster dose administered to most healthy children at age 12-15 months. PMID: 19553904 [PubMed - indexed for MEDLINE] (Source: MMWR Morb Morta...

CDC Reinstates Recommendation for Haemophilus Vaccine Booster (CME/CE)

MedPage Today Infectious Disease — Thu, 25 Jun 2009 16:28:02 +0100

ATLANTA (MedPage Today) -- With a shortage of Haemophilus influenzae type b (Hib) vaccine now relieved, the CDC is again recommending that most children receive a booster dose at 12 to 15 months of age. (Source: MedPage Today Infectious Disease)

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CDC to reinstate booster shots of HiB vaccine

Reuters: Health — Thu, 25 Jun 2009 15:21:52 +0100

CHICAGO (Reuters) - The U.S. Centers for Disease Control and Prevention said on Thursday it plans to reinstate booster shoots of a vaccine that protects children against bacterial meningitis. (Source: Reuters: Health)

CDC to reinstate booster shots for HiB vaccine

Reuters: Health — Thu, 25 Jun 2009 14:35:00 +0100

CHICAGO (Reuters) - The U.S. Centers for Disease Control and Prevention said on Thursday it plans to reinstate booster shoots of a vaccine that protects babies and toddlers against bacterial meningitis. (Source: Reuters: Health)

CDC to Reinstate Booster Shots of HiB Vaccine

MedlinePlus Health News — Thu, 25 Jun 2009 14:21:52 +0100

The U.S. Centers for Disease Control and Prevention said on Thursday it plans to reinstate booster shoots of a vaccine that protects children against bacterial meningitis. Source: Reuters Health Related MedlinePlus Topic: Childhood Immunization (Source: MedlinePlus Health News)

Invasive Haemophilus influenzae Type b Disease in Five Young Children—Minnesota, 2008

Annals of Emergency Medicine — Thu, 25 Jun 2009 07:36:09 +0100

[Centers for Disease Control and Prevention. Invasive Haemophilus influenzae type b disease in five young children—Minnesota, 2008. MMWR Morb Mortal Wkly Rep. 2009;58:58-60.] In 2008, 5 children younger than 5 years were reported to the Minnesota Department of Health (MDH) with invasive Haemophilus influenzae type b (Hib) disease; one child died. Only 1 of the children had completed the primary Hib immunization series; 3 had received no doses of Hib-containing vaccine. The 5 Hib cases are the largest number among children younger than 5 years reported from Minnesota since 1992. The cases occurred during a Hib vaccine recall and continuing nationwide shortage that began in December 2007. The recall of certain lots of the 2 Hib-containing vaccines manufactured by Merck and Co., Inc. (West...

Commentary

Annals of Emergency Medicine — Thu, 25 Jun 2009 07:36:09 +0100

[Ann Emerg Med. 2009;54:85.] Historically, emergency physicians were well acquainted with invasive disease caused by Hib. Today, most physicians in training will finish residency never having seen a child present with complications caused by Hib. Since 1990, a conjugate Hib vaccine has decreased the annual incidence of invasive disease to near nondetectable levels. However, the above report describes an unusually high frequency of cases identified in 2008 in Minnesota, mainly among underimmunized children. (Source: Annals of Emergency Medicine)

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Sanofi Pasteur Responds To Nation's Need For Hib Vaccine With Increased Supply

Pharmaceutical Online News — Thu, 25 Jun 2009 05:46:00 +0100

Sanofi Pasteur, the vaccines division of the sanofi-aventis Group (EURONEXT: SAN and NYSE: SNY), announced today that the company has been able to increase the supply of its Hib-containing vaccines to enable the return to a full series of vaccinations for U.S. children. (Source: Pharmaceutical Online News)

Clinical characteristics of Haemophilus influenzae meningitis in Denmark in the post-vaccination era

Clinical Microbiology and Infection — Sun, 21 Jun 2009 23:00:00 +0100

In conclusion, meningitis caused by Hib has been infrequent in Denmark after introduction of the Hib vaccine in the childhood vaccination programme, and no increase in meningitis cases due to non-b type H. influenzae has been observed. Cases with H. influenzae meningitis frequently had an otogenic focus, with low risk of an unfavourable outcome. (Source: Clinical Microbiology and Infection)

Humoral immunity to diphtheria, tetanus, measles, and hemophilus influenzae type b in children with acute lymphoblastic leukemia and response to re-vaccination

Pediatric Blood and Cancer — Wed, 17 Jun 2009 23:00:00 +0100

Loss of immunity to previous vaccination and timing of re-vaccination in children receiving chemotherapy remains controversial. The aim of this study was to investigate the immunity to vaccine preventable diseases in children with acute lymphoblastic leukemia (ALL).Sixty-one patients with ALL and 13 healthy siblings were enrolled. Three study groups included newly diagnosed patients (group 1), patients on maintenance chemotherapy (group 2), and patients that completed chemotherapy (group 3). Blood samples for baseline antibody titers were obtained from all the patients and controls. Patients in group 2 were vaccinated with diphtheria, tetanus, and hemophilus influenzae type b (Hib). Patients in group 3 and controls received the measles vaccine in addition to all the above vaccines. In grou...

Reduction of meningitis and impact on under-5 pneumonia after introducing the Hib vaccine in the Kingdom of Tonga.

Annals of Tropical Paediatrics — Sun, 31 May 2009 23:00:00 +0100

CONCLUSION: Hib vaccine has reduced invasive Hi disease and Hi meningitis in Tonga. The reduction in inpatient pneumonia is more likely a reflection of annual fluctuations in viral pneumonia than of a reduction in Hib pneumonia, but ongoing surveillance is recommended. PMID: 19460264 [PubMed - in process] (Source: Annals of Tropical Paediatrics)

Primary and booster immunization with a diphtheria, tetanus, acellular pertussis, hepatitis B (DTPa–HBV) and Haemophilus influenzae type b (Hib) vaccine administered separately or together is safe and immunogenic

International Journal of Infectious Diseases — Thu, 21 May 2009 00:00:00 +0100

Summary: Objectives: The aim of this study was to evaluate the safety and immunogenicity of DTPa–HBV and Hib vaccines given mixed or separately to 360 healthy infants at 2, 4, and 6 months of age.Methods: Immune memory was assessed in lower responders (post-primary anti-PRP (Source: International Journal of Infectious Diseases)

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Infants' Pain Response To Immunization Varies Based On Which Vaccine Is First

Health News from Medical News Today — Wed, 13 May 2009 10:00:00 +0100

Infants who receive the pneumococcal conjugate vaccine (PCV) following the combination vaccine for diphtheria, polio, tetanus, pertussis and Haemophilus influenza type b (DPTaP-Hib vaccine) appear to experience less pain than those who are immunized in the opposite order, according to a report in the May issue of Archives of Pediatrics & Adolescent Medicine, a theme issue on vaccines. (Source: Health News from Medical News Today)

The Order Of Vaccine Injections Has An Effect On The PainÂ´s Feedback In Infants

Health News from Medical News Today — Wed, 06 May 2009 07:00:00 +0100

A report in the May issue of Archives of Pediatrics & Adolescent Medicine indicates that infants who receive the pneumococcal conjugate vaccine (PCV) after being given the grouping vaccine for diphtheria, polio, tetanus, pertussis and Haemophilus influenza type b (DPTaP-Hib vaccine) seem to experience less pain than other infants who are given the vaccinations in the reverse order. (Source: Health News from Medical News Today)

ARTICLE: Progress in Timely Vaccination Coverage Among Children Living in Low-Income Households

Archives of Pediatrics — Mon, 04 May 2009 04:00:00 +0100

Conclusions Disparities in vaccination coverage associated with low household income persist. Further progress in timely vaccination may be achieved by improving health care providers' reminder/recall systems, implementing educational interventions that address barriers to vaccination, and increasing parents' awareness of the Vaccines for Children Program. (Source: Archives of Pediatrics)

ARTICLE: Order of Vaccine Injection and Infant Pain Response

Archives of Pediatrics — Mon, 04 May 2009 04:00:00 +0100

Conclusions Pain was reduced when the DPTaP-Hib vaccine was administered before the PCV in infants undergoing routine vaccination. We recommend that the order of vaccine injections be the DPTaP-Hib vaccine followed by the PCV. Trial Registration clinicaltrials.gov Identifier: NCT00390130 (Source: Archives of Pediatrics)

Government Stipulates To Lump Sum, Annuity For Vaccine Injuries

LexisNexis® Mealey's™ Thimerosal & Vaccines Legal News — Mon, 20 Apr 2009 12:21:14 +0100

WASHINGTON, D.C. - While denying that a petitioner was injured by the diphtheria-tetanus-acellular pertussis (DTaP) or haemophilus influenzae type b (HIB) vaccines, the government on March 17 agreed to pay a lump sum of $769,803 plus an annuity for counseling (Jason Agresti, et al. v. Secretary, No. 05-752V, Fed. Clms., Off. Spec. Masters). Full story on lexis.com (Source: LexisNexis® Mealey's™ Thimerosal & Vaccines Legal News)

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Invasive Haemophilus influenzae infections in Germany: impact of non-type b serotypes in the post-vaccine era

BMC Infectious Diseases — Mon, 20 Apr 2009 04:00:00 +0100

Conclusions: There was no increase in non-type b Hi invasive infections during 8 years of active surveillance in Germany. Invasive disease due to non-type b Hi is not confined to children with risk factors. In patients with capsulated non-type b Hi infections the proportion of meningitis cases is similar to Hib, but double as high as in non-capsulated Hi. (Source: BMC Infectious Diseases)

Second Disease Outbreak Illustrates Heightened Need to Complete Hib Primary Series

AAFP Clinical Care and Research — Tue, 24 Mar 2009 19:40:00 +0100

The AAFP has issued a statement agreeing with recommendations laid out in a CDC health advisory disseminated in the wake of an ongoing nationwide shortage of Haemophilus influenzae type b, or Hib, vaccine. In its statement, the Academy advises members who are having difficulty obtaining an adequate supply of Hib-containing vaccine to contact their vaccine suppliers and, if necessary, their state health departments. (Source: AAFP Clinical Care and Research)

Petition Fails For Lack Of An Expert To Show Causation

LexisNexis® Mealey's™ Thimerosal & Vaccines Legal News — Fri, 20 Mar 2009 06:30:26 +0100

WASHINGTON, D.C. - The Office of Special Masters has denied compensation to a petitioner who provided no expert to back up her contention that the measles, mumps and rubella (MMR) varicella and hemophilus influenzae type b (Hib) vaccines caused her son's idiopathic thrombocytopenia purpura, a seizure disorder and unspecified neurologic injuries (Mariana Ruvalcaba v. Secretary, No. 07-259V, Fed. Clms., Off. Spec. Masters). Full story on lexis.com (Source: LexisNexis® Mealey's™ Thimerosal & Vaccines Legal News)

Burden of Invasive Disease Caused by Haemophilus influenzae Type b in Asia.

Japanese Journal of Infectious Diseases — Sun, 01 Mar 2009 05:00:00 +0100

Authors: Broker M Globally, Haemophilus influenzae type b (Hib) is one of the leading causes of childhood meningitis and pneumonia. Vaccines against Hib have been developed and introduced into routine immunization programs in most industrialized nations, in which the burden of Hib disease has been clearly demonstrated. In Asia, the burden of Hib disease has been perceived as relatively low compared with other parts of the world. However, the results of several recent studies have allowed for a more cautious assessment of the disease burden in different populations and settings throughout Asia. These studies suggest that the true burden of Hib disease may have been underestimated, and point to several key factors that may have contributed to this problem, such as antibiotic use prior to...

CDC Urging Docs to Complete Hib Primary Series

AAFP Clinical Care and Research — Wed, 25 Feb 2009 22:40:00 +0100

With the nation's shortage of Haemophilus influenzae type b, or Hib, vaccine now stretching into its 15th month, the CDC is directly contacting thousands of health care providers with a reminder that all children should complete the primary Hib immunization series. (Source: AAFP Clinical Care and Research)

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DSHS Issues Pentacel Advisory

Blogged_Arteries — Thu, 05 Feb 2009 00:00:00 +0100

State health officials say physicians should use Pentacel only for the first three doses of the diphtheria, tetanus, pertussis (DTaP), inactivated polio vaccine (IPV), and Haemophilus influenzae type b (Hib) vaccination series until the U.S. supply of the Hib vaccine improves. (Source: Blogged_Arteries)

Cameroon: Health - New free vaccine for children

AllAfrica News: Health and Medicine — Mon, 02 Feb 2009 14:41:13 +0100

The DTC Hep + Hib vaccine will be officially launched on February 4 in Okola in the Lekié Division of the Centre Region. (Source: AllAfrica News: Health and Medicine)

Is Hib vaccine of economic value in South Korea?

J Korean Med Sci — Sun, 01 Feb 2009 05:00:00 +0100

Authors: Griffiths UK, Edmond K, Hajjeh R PMID: 19270839 [PubMed - in process] (Source: J Korean Med Sci)

Invasive Haemophilus influenzae Type B disease in five young children--Minnesota, 2008.

MMWR Morb Mortal Wkl... — Fri, 30 Jan 2009 05:00:00 +0100

Authors: In 2008, five children aged <5 years were reported to the Minnesota Department of Health (MDH) with invasive Haemophilus influenzae type b (Hib) disease; one died. Only one of the children had completed the primary Hib immunization series; three had received no doses of Hib-containing vaccine. The five Hib cases are the largest number among children aged <5 years reported from Minnesota since 1992. The cases occurred during a Hib vaccine recall and continuing nationwide shortage that began in December 2007. The recall of certain lots of the two Hib-containing vaccines manufactured by Merck Co., Inc. (West Point, Pennsylvania) and cessation of production of both vaccines left only one manufacturer of Hib vaccine in the United States (Sanofi Pasteur, Swiftwater, Pennsylv...

Hib Cases Jumped In Minnesota In 2008, Vaccine Shortage Led To Fewer Immunizations

Health News from Medical News Today — Sat, 24 Jan 2009 10:00:00 +0100

The reappearance of the childhood infectious disease Haemophilus influenza type B (Hib) in Minnesota last year has prompted authorities to acquire extra vaccines. The Minnesota Department of Health is urging parents to work with their health care providers so that infants receive the recommended primary series of three doses of Hib vaccine. (Source: Health News from Medical News Today)

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DTP poliovirus vaccine/Hib vaccine/Hib-DTP-poliovirus vaccine: Discoloured leg syndrome in infants: 2 case reports

Reactions — Sat, 24 Jan 2009 07:16:13 +0100

(Source: Reactions)

Increase in meningitis prompts CDC warning

BCBS.com: General Headlines — Sat, 24 Jan 2009 05:00:00 +0100

Merck & Co. in 2007 recalled its Hib vaccines because production equipment may not have been properly sterilized. Hib vaccine made by Sanofi Pasteur, the vaccines division of Sanofi-Aventis, remains available. Vaccination has cut that by 99 percent, officials said. (Source: BCBS.com: General Headlines)

CDC Stresses Importance of Hib Vaccination for Young Children

MedPage Today Public Health — Fri, 23 Jan 2009 21:02:29 +0100

ATLANTA (MedPage Today) -- Prompted by an unusual uptick in cases of invasive Haemophilus influenzae type b (Hib) in Minnesota, the CDC urged parents today to make sure their young children are fully vaccinated with the primary series of three doses. (Source: MedPage Today Public Health)

Incremental system costs of introducing combined DTwP-hepatitis B-Hib vaccine into national immunization services in Ethiopia.

Vaccine — Mon, 12 Jan 2009 05:00:00 +0100

CONCLUSION: In Ethiopia introduction of pentavalent vaccine necessitated considerable investments in additional cold storage equipment as well as an increase in vaccine transport frequency. A GAVI Alliance introduction grant of US$ 0.30 per child in the birth cohort would cover approximately 20% of the capital investments undertaken to facilitate introduction. PMID: 19146901 [PubMed - as supplied by publisher] (Source: Vaccine)

Safety and Immunogenicity of a Pentavalent Vaccine Compared With Separate Administration of Licensed Equivalent Vaccines in US Infants and Toddlers and Persistence of Antibodies Before a Preschool Booster Dose: A Randomized, Clinical Trial

PEDIATRICS — Mon, 29 Dec 2008 05:00:00 +0100

CONCLUSIONS. DTaP5-IPV-Hib combination vaccine was shown to be immunogenic and well tolerated. No clinically important differences in the safety or immunologic profiles were noted for DTaP5-IPV-Hib versus the separately administered, US-licensed equivalent vaccines. DTaP5-IPV-Hib is a suitable replacement for separately administered DTaP, IPV, and Hib vaccines. (Source: PEDIATRICS)

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Malaria vaccine trial offers hope

Guardian Unlimited Science — Tue, 09 Dec 2008 00:16:09 +0100

Trials in Africa of a new malaria vaccine have shown it more than halves the number of serious bouts of the disease in small children, it was revealed yesterday.Expectations are high for the vaccine, which has already shown promise in early trials. The latest trial results, published online in the New England Journal of Medicine (NEJM), are better than before. Early trials in Mozambique found the vaccine reduced by almost a third the number of cases of malaria warranting clinical care. In the new trials in Tanzania and Kenya, it reduced such cases by 53% in five- to 17-month-old babies. Malaria kills almost a million people a year, mostly babies and small children in Africa.This is the latest of a series of trials designed to test the efficacy of the vaccine RTS,S - which is being develope...

[NEWS AND FEATURES] Hib vaccine supplies still low; continue deferring booster dose

AAP News — Mon, 01 Dec 2008 05:00:00 +0100

(Source: AAP News)

Immunogenicity and Safety of Two Different Haemophilus influenzae Type b Conjugate Vaccines in Korean Infants.

J Korean Med Sci — Mon, 01 Dec 2008 05:00:00 +0100

Authors: Kim KH, Lee H, Chung EH, Kang JH, Kim JH, Kim JS, Lee HJ, Oh SH, Park EA, Park SE The incidence of invasive diseases, including meningitis caused by Haemophilus influenzae type b (Hib) was markedly decreased after routine immunization of Hib vaccine through diverse schedules in many countries. The purpose of this study was to evaluate the immunogenicity and safety of Hib conjugate vaccines in Korean children before the implementation of a national immunization program against Hib in Korea. A multicenter controlled trial was performed on two different Hib vaccines in Korean children. A total of 319 infants were enrolled: 199 infants were immunized with the Hib polysaccharide conjugated to the tetanus toxoid (PRP-T) and 120 infants with the Hib polysaccharide conjugated to the o...

Hib Vaccine Shortage in US Makes Surveillance Critical

Medscape PublicHealth Headlines — Fri, 21 Nov 2008 17:49:04 +0100

As a shortage of Haemophilus influenzae type b (Hib) conjugate vaccines is expected to persist until mid-2009, clinicians are advised to increase their efforts to serotype and report all cases of invasive H. influenzae disease in young children. Reuters Health Information (Source: Medscape PublicHealth Headlines)

CDC Monitors Shortage of Hib Vaccine

MedicineNet Senior Health General — Fri, 21 Nov 2008 07:00:00 +0100

Title: CDC Monitors Shortage of Hib VaccineCategory: Health NewsCreated: 11/21/2008 2:00:00 AMLast Editorial Review: 11/21/2008 (Source: MedicineNet Senior Health General)

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Continued Shortage of Haemophilus influenzae Type b (Hib) Conjugate Vaccines and Potential Implications for Hib Surveillance --- United States, 2008.

MMWR Morb Mortal Wkl... — Fri, 21 Nov 2008 05:00:00 +0100

Authors: In December 2007, Merck & Co., Inc. (West Point, Pennsylvania) announced a voluntary recall of certain lots of two Haemophilus influenzae type b (Hib) conjugate vaccines, PedvaxHIB(R) (monovalent Hib vaccine) and Comvax(R) (Hib-HepB vaccine) and suspended production of both vaccines, disrupting the U.S. supply of Hib vaccine. When the recall was announced, Merck projected restoration of these vaccines to the U.S. market in late 2008. To ensure that enough vaccine would be available for all U.S. children to complete the primary Hib vaccination series, on December 18, 2007, CDC recommended that providers defer the booster dose of Hib vaccine (scheduled for administration at age 12--15 months) for all children except those at increased risk for invasive Hib disease. On Octo...

Hib Vaccine Shortage Extended

WebMD Health — Thu, 20 Nov 2008 05:00:00 +0100

The current U.S. shortage of childhood Hib vaccine, cut off in December 2007, will continue at least until mid-2009, the CDC warns. (Source: WebMD Health)

DTaP-IPV/Hib Vaccine (Pentacel)

Pediatric Drugs — Sat, 15 Nov 2008 08:35:47 +0100

(Source: Pediatric Drugs)

DTaP-IPV/Hib Vaccine (Pentacel((R))).

Paediatric Drugs — Thu, 13 Nov 2008 16:53:44 +0100

Authors: Dhillon S, Keam SJ PMID: 18998751 [PubMed - in process] (Source: Paediatric Drugs)

DTaP-IPV/Hib Vaccine (Pentacel(R)).

Pediatric Drugs — Thu, 13 Nov 2008 11:35:40 +0100

Page: 405DOI: 10.2165/0148581-200810060-00008Authors: Dhillon, Sohita; Keam, Susan J (Source: Pediatric Drugs)

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Forecasting demand for Hib-containing vaccine in the world's poorest countries: A 4-year prospective experience.

Vaccine — Wed, 12 Nov 2008 05:00:00 +0100

This article analyzes the performance of a Hib vaccine demand forecast developed in 2003 for 68 GAVI-supported countries between 2004 and 2007. During that period of time, corresponding to an acceleration of Hib vaccine uptake, several groups of countries were identified based on the stage of their decision-making process, perception of Hib disease burden and programme performance. Better forecast accuracy was obtained for countries having already introduced the vaccine or that were about to do so. The ability to anticipate global needs in terms of vaccine volumes was highly dependant on the actual year of introduction of a small number of very large countries. PMID: 19013493 [PubMed - as supplied by publisher] (Source: Vaccine)

Immunogenicity, reactogenicity and consistency of production of a Brazilian combined vaccine against diphtheria, tetanus, pertussis and Haemophilus influenzae type b.

Memorias do Instituto Oswaldo Cruz — Sat, 01 Nov 2008 04:00:00 +0100

Authors: Martins RD, Camacho LA, Marcovistz R, Noronha TG, Maia MD, Santos EM, Barbosa GG, Silva AM, Souza PC, Lemos MC, Homma A A randomized, double-blinded study evaluating the immunogenicity, safety and consistency of production of a combined diphtheria-tetanus-pertussis-Haemophilus influenzae type b vaccine entirely produced in Brazil by Bio-Manguinhos and Instituto Butantan (DTP/Hib-BM) was undertaken. The reference vaccine had the same DTP vaccine but the Hib component was produced using purified materials supplied by GlaxoSmithKline (DTP/Hib-GSK), which is registered and has supplied the Brazilian National Immunization Program for over more than five years. One thousand infants were recruited for the study and received vaccinations at two, four and six months of age. With respec...

Coadministration of RIX4414 Oral Human Rotavirus Vaccine Does Not Impact the Immune Response to Antigens Contained in Routine Infant Vaccines in the United States

PEDIATRICS — Fri, 31 Oct 2008 04:00:00 +0100

CONCLUSIONS. Two doses of RIX4414 coadministered with routine infant vaccines as recommended in the United States (DTaP-HBV-IPV, PCV7, and Hib) did not impair the immune response to any of the coadministered antigens. (Source: PEDIATRICS)

Japanese launch of paediatric conjugate Hib vaccine delayed.

Inpharma — Mon, 13 Oct 2008 06:58:10 +0100

(Source: Inpharma)

Japanese launch of paediatric conjugate Hib vaccine delayed.

Inpharma Weekly — Sat, 11 Oct 2008 10:37:18 +0100

Page: 23 (Source: Inpharma Weekly)

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Reactogenicity of infant whole cell pertussis combination vaccine compared with acellular pertussis vaccines with or without simultaneous pneumococcal vaccine in the Netherlands.

Vaccine — Tue, 02 Sep 2008 04:00:00 +0100

CONCLUSION: Whole cell pertussis vaccine showed a significantly higher reactogenicity regarding the adverse events analysed, while addition of conjugated pneumococcal vaccine administered simultaneously with acellular pertussis showed no statistically different adverse event profile. PMID: 18775463 [PubMed - as supplied by publisher] (Source: Vaccine)

Hib Disease Declines After Booster Campaign

Medscape PublicHealth Headlines — Sat, 16 Aug 2008 03:20:43 +0100

Haemophilus influenzae serotype b (Hib) cases declined significantly following a Hib vaccination booster campaign in England and Wales targeting young children, according to a report in the August issue of the Archives of Disease in Childhood. Reuters Health Information (Source: Medscape PublicHealth Headlines)

[VACCINE UPDATE] DTaP-IPV/Hib vaccine approved for infants, toddlers

AAP News — Fri, 01 Aug 2008 04:00:00 +0100

(Source: AAP News)

[Original articles] Fall in Haemophilus influenzae serotype b (Hib) disease following implementation of a booster campaign

Archives of Disease in Childhood — Mon, 21 Jul 2008 04:00:00 +0100

Conclusions: The Hib booster campaign has helped to re-establish herd immunity in the UK. The increase in Hib disease among toddlers after 2004 supports the decision to introduce routine boosting for Hib at 12 months of age. (Source: Archives of Disease in Childhood)

[Original articles] Host and environmental factors associated with Hib in England, 1998-2002

Archives of Disease in Childhood — Mon, 21 Jul 2008 04:00:00 +0100

Conclusions: The association noted between invasive infection and social deprivation in this and other studies is concerning and merits further investigation. The importance of ongoing surveillance of vaccine-preventable diseases to allow nested studies of this kind was reinforced. (Source: Archives of Disease in Childhood)

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Immunogenicity, Reactogenicity and Safety of a Diphtheria-Tetanus-Acellular Pertussis-Inactivated Polio and Haemophilus Influenzae Type b Vaccine in a Placebo-controlled Rotavirus Vaccine Study.

Annals of the Academy of Medicine, Singapore — Tue, 01 Jul 2008 04:00:00 +0100

Conclusion: The combined DTPa- IPV/Hib vaccine is safe, well tolerated and highly immunogenic when given alone or coadministered with the rotavirus vaccine for infants in Singapore. PMID: 18695765 [PubMed - in process] (Source: Annals of the Academy of Medicine, Singapore)

Incidence of Haemophilus influenzae type b meningitis in India.

The Indian Journal of Medical Research — Tue, 01 Jul 2008 04:00:00 +0100

CONCLUSION: Our data are the first minimal estimate of the incidence of Hib meningitis for Indian children. The observed incidence data are similar to European reports before Hib vaccine use, suggest substantial disease before 24 months of age, and provide data useful for policy regarding Hib immunization. PMID: 18820360 [PubMed - in process] (Source: The Indian Journal of Medical Research)

Haemophilus influenzae type b conjugate vaccine use and effectiveness.

The Lancet Infectious Diseases — Sat, 28 Jun 2008 17:54:06 +0100

Authors: Morris SK, Moss WJ, Halsey N Haemophilus influenzae type b (Hib) is an important cause of invasive bacterial disease in children, including meningitis and pneumonia. The introduction of Hib conjugate vaccines into routine vaccination schedules has contributed to a substantial reduction in the burden of Hib-related disease in many developed countries. However, introduction of Hib conjugate vaccines in developing countries has progressed more slowly. We review the worldwide use and effectiveness of Hib conjugate vaccines. At present, 119 countries have programmes for routine Hib immunisation. WHO estimates that in the developed world 92% of the eligible population is vaccinated against Hib; however, average coverage is 42% in developing countries and only 8% in the poorest count...

The Finnish decision-making process to recommend a new vaccine: From vaccine research to vaccination policy

Journal of Public Health — Sat, 28 Jun 2008 07:59:27 +0100

Conclusion Surveillance and research are valuable tools for modern vaccine programme design. Market forces and advocacy groups strongly drive the development and implementation of new vaccines, meaning that impartial and evidence-based decision-making is essential to vaccine introduction into national programmes. At the same time, economic analyses are occupying an increasingly important place in this decision-making. Vaccine costs are not necessarily compared to government expenditure on illness and disease. From a moral point of view, it should not be forgotten that children ought to have the right to best available health. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10389-008-0204-yAuthors Hanna Nohynek, Mannerheimintie 166 FIN-00300 Helsink...

Acute epiglottitis in Iceland 1983-2005.

Auris, Nasus, Larynx — Thu, 22 May 2008 04:00:00 +0100

CONCLUSION: There have been major changes in the epidemiology of epiglottitis in Iceland during the study period. Previously a childhood disease, epiglottitis has disappeared in children and is now almost exclusively found in adults. This can be attributed to widespread Hib vaccination, eliminating the major causative agent in children. The treatment of this life-threatening disease remains a challenge. Our series suggest that it is safe to observe patients with mild/moderate symptoms without airway intervention. PMID: 18502071 [PubMed - as supplied by publisher] (Source: Auris, Nasus, Larynx)

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Diagnosis and management of supraglottitis (Epiglottitis)

Current Infectious Disease Reports — Fri, 16 May 2008 06:14:47 +0100

Abstract Acute supraglottitis is a serious, potentially fatal infection in both adults and children. Haemophilus influenzae type b (Hib) is the most common cause in children, even in this era of the Hib vaccine. Most cases of acute supraglottitis in adults are thought to be caused by other bacterial organisms, viral or combined viral-bacterial infections, and noninfectious etiologies. Early visualization of the larynx is essential, as is establishment of a secure airway in selected cases. Most cases will respond to intravenous antibiotic therapy and will not require an artificial airway. Admission to an area of high-intensity nursing is essential. Daily laryngoscopy is necessary to monitor response to treatment. Although the incidence of acute supraglottitis in children has...

Immunogenicity and reactogenicity of DTPa-HBV-IPV/Hib vaccine as primary and booster vaccination in low-birth-weight premature infants

Acta Paediatrica — Fri, 16 May 2008 04:00:00 +0100

Aim: To assess suitability of a combined DTPa-HBV-IPV/Hib vaccine (Infanrix hexa[trade]) for immunization of low-birth-weight ( (Source: Acta Paediatrica)

Corticosteroids don't affect mortality in children with meningitis

NeLM Headline News — Wed, 07 May 2008 00:00:00 +0100

This study was intended to determine whether corticosteroid treatment affected mortality and length of hospital treatment in children with bacterial meningitis in an area where Hib vaccination was widespread. The study cohort was derived from an administrative database of resource utilisation data provided by about 20% of US tertiary care children's hospitals; it included all children younger than 18 discharged from any of the participating hospitals with a diagnosis of bacterial meningitis, excluding those with pre-existing ventricular shunts. Study period was 2001 to 2006 inclusive, the exposure of interest was administration of corticosteroid during the first 24 hours after admission, and the main outcome measures were time to death and time to hospital discharge. There were 2,780 pat...

Progress in Vaccination against Haemophilus influenzae type b in the Americas

PLoS Medicine — Tue, 29 Apr 2008 07:00:47 +0100

The authors review the progress to date in Hib vaccine introduction, the lessons learned, and the remaining challenges. (Source: PLoS Medicine)

[News and Features] Reminder: Defer Hib vaccine for healthy 12- to 15-month olds

AAP News — Fri, 25 Apr 2008 04:00:00 +0100

(Source: AAP News)

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Reminder: Defer Hib vaccine for healthy 12- to 15-month olds [News and Features]

AAP News — Thu, 24 Apr 2008 23:00:00 +0100

(Source: AAP News)

Uganda: Country is Meningitis-Free - WHO

AllAfrica News: Health and Medicine — Mon, 21 Apr 2008 13:54:21 +0100

MENINGITIS has been eliminated in children in Uganda five years since the introduction of Haemophilus influenzae type b (Hib) vaccine, a study has revealed. (Source: AllAfrica News: Health and Medicine)

How much progress has there been in vaccinating against Hib in the Americas?

EurekAlert! - Infectious and Emerging Diseases — Mon, 21 Apr 2008 04:00:00 +0100

In a policy paper in this week's PLoS Medicine, M. Carolina Danovaro-Holliday and colleagues examine the progress of Hib vaccine introduction in the Americas. (Source: EurekAlert! - Infectious and Emerging Diseases)

[NEWS AND FEATURES] Reminder: Suspend administering booster dose of Hib vaccine

AAP News — Tue, 01 Apr 2008 04:00:00 +0100

(Source: AAP News)

Action for child survival: elimination of Haemophilus influenzae type b meningitis in Uganda.

Bulletin of the World Health Organization — Tue, 01 Apr 2008 04:00:00 +0100

CONCLUSION: Infant immunization with Hib vaccine has virtually eliminated Hib meningitis in Uganda within 5 years. Ensuring long-term benefits of Hib vaccine urgently requires sustainable vaccine financing, high-quality ongoing surveillance, and a health sector able to deliver a robust immunization programme. PMID: 18438518 [PubMed - in process] (Source: Bulletin of the World Health Organization)

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Uganda: Widespread Vaccination Eliminates Deadly Disease in Children

AllAfrica News: Health and Medicine — Tue, 11 Mar 2008 19:21:18 +0100

Haemophilus influenzae type b (Hib) meningitis has been virtually eliminated in young children in Uganda, just five years after the country introduced the (Hib) vaccine nationwide, according to an independent study. (Source: AllAfrica News: Health and Medicine)

Nearly 100 Percent Drop In Hib Meningitis As A Result Of Widespread Vaccination

Infectious Diseases / Bacteria / Viruses News From Medical News Today — Tue, 11 Mar 2008 10:00:00 +0100

Hib meningitis has been virtually eliminated in young children in Uganda just five years after the country introduced Haemophilus influenzae type b (Hib) vaccine nationwide, according to an independent study. Haemophilus influenzae type b is a leading cause of pneumonia and meningitis, an inflammation of the lining covering the brain and spinal cord. Each year, Hib kills approximately 400,000 children under five years of age, most of them in the developing world. (Source: Infectious Diseases / Bacteria / Viruses News From Medical News Today)

Vaccine Shortage Dictates Deferring Hib Booster in Healthy Kids

AAFP Clinical Care and Research — Wed, 05 Mar 2008 22:30:00 +0100

For a typical family medicine practice, administering immunizations is part and parcel of the everyday routine -- especially when it comes to youngsters who've come in for their well-child visits. So, deciding to forgo a key piece of the recommended childhood immunization schedule may seem counterintuitive. In the face of an ongoing shortage of Haemophilus influenzae type b, or Hib, conjugate vaccine, however, the CDC is reminding vaccine providers about an interim recommendation that urges temporary deferral of the Hib vaccine booster usually given to healthy children at the 12- or 15-month visit except for certain high-risk children. (Source: AAFP Clinical Care and Research)

Haemophilus influenzae type b conjugate vaccine is highly effective in the Ugandan routine immunization program: a case–control study

Tropical Medicine and International Health — Tue, 26 Feb 2008 20:08:27 +0100

Tropical Medicine & International Health, Volume 0, Issue 0, Page ???, OnlineEarly Articles. SummaryobjectiveTo study the effectiveness of the Haemophilus influenzae type b (Hib) vaccination program in Uganda.methodsCase–control study of Hib vaccine effectiveness against Hib meningitis. Cases were children hospitalized with Hib meningitis ... (Source: Tropical Medicine and International Health)

Two variants among Haemophilus influenzae serotype b strains with distinct bcs4, hcsA and hcsB genes display differences in expression of the polysaccharide capsule

BMC Microbiology - Latest articles — Mon, 25 Feb 2008 05:00:00 +0100

Conclusion: Type II strains were only isolated during the pre-vaccination era from young, non-vaccinated individuals and displayed a lower expression of capsular polysaccharide than type I strains. The higher polysaccharide expression may have provided a selective advantage for type I strains resulting in the rapid elimination of type II from the Dutch Hib population after introduction of nationwide Hib vaccination. However, this phenomenon does not explain the increase in the number of Hib vaccine failures in the Netherlands. (Source: BMC Microbiology - Latest articles)

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Progress toward introduction of Haemophilus influenzae type b vaccine in low-income countries--worldwide, 2004-2007.

MMWR Morb Mortal Wkl... — Fri, 15 Feb 2008 05:00:00 +0100

Authors: Haemophilus influenzae type b (Hib) disease is estimated to cause 3 million cases of meningitis and severe pneumonia and approximately 386,000 deaths worldwide per year in children aged <5 years. Safe and effective Hib conjugate vaccines have been widely used in industrialized countries for nearly 20 years. However, primarily because of financial constraints and lack of awareness among both public health officials and the public regarding Hib disease burden and benefits of the vaccine, use of these vaccines has been low in developing countries, where most Hib disease and deaths occur. In 2000, the GAVI Alliance (formerly known as the Global Alliance for Vaccines and Immunizations) began providing financial support for Hib vaccine in 72 countries that had a gross national ...

Placental transfer of Haemophilus influenzae type b antibodies in malnourished pregnant women.

Braz J Infect Dis — Fri, 01 Feb 2008 05:00:00 +0100

This study evaluated the vaccination response to Haemophilus influenzae type b (Hib) in malnourished pregnant women (MN), cord blood (CB) and in infants at two and six months of age for comparison with a control group (C). Twenty-eight malnourished pregnant women and 29 pregnant controls were immunized with conjugated Act-HIB(R) in the third trimester of pregnancy. Blood samples were collected from all before the immunization, during labor (post immunization), and from CB. All infants were immunized with Hib vaccine according to normal vaccine schedule and sera were collected at two and six months of age. Antibody levels to polyribosylribitol phosphate (PRP) were similar for both groups. Preimmunization: MN 1.94 microg/mL, C 1.68 microg/mL; post-vaccination: MN 18.53 microg/mL and C 17.55 ...

Reproductive and Child Health Inequities in Chandigarh Union Territory of India

Journal of Urban Health — Wed, 16 Jan 2008 16:00:18 +0100

Abstract Health inequity is an emerging issue all over the world. Some populations living in specific geographic areas may have less access to basic health facilities. Therefore, a sample survey of households was carried out to study access of different population groups to reproductive and child health. Cluster sampling technique was used to select 30 clusters (18 urban, 9 slum, and 3 rural) from Chandigarh Union Territory in India. From each of these clusters, 40 households were selected randomly. Data were collected using a standard questionnaire developed by UNICEF from April to June 2006 by graduate male and female field workers who were specially recruited and trained for this purpose. A total of 5383 individuals were studied in 1200 sample households with proportion...

Hib booster dose should be deferred until vaccine shortage is over

Drug Topics - Hot off the Press — Thu, 03 Jan 2008 05:00:00 +0100

Interim recommendations issued for Hib vaccine shortage (Source: Drug Topics - Hot off the Press)

December 21, 2007: In the News

Medscape FamilyMedicine Headlines — Fri, 21 Dec 2007 15:25:42 +0100

A new study finds uninsured cancer patients are twice as likely to die within 5 years as those with health insurance. Also today, a call to halt Hib vaccines. (Source: Medscape FamilyMedicine Headlines)

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Interim recommendations for the use of Haemophilus influenzae type b (Hib) conjugate vaccines related to the recall of certain lots of Hib-containing vaccines (PedvaxHIB and Comvax).

MMWR Morb Mortal Wkl... — Fri, 21 Dec 2007 05:00:00 +0100

Authors: On December 13, 2007, Merck & Co., Inc. (West Point, Pennsylvania) announced a voluntary recall of certain lots of two Haemophilus influenzae type b (Hib) conjugate vaccines, PedvaxHIB (monovalent Hib vaccine) and Comvax(R) (Hib/hepatitis B vaccine). Providers should return unused vaccine from these recalled lots using procedures outlined on the Merck website at http://www.merckvaccines.com/PCHRecall.pdf. Additional information regarding the affected lots is available online from the Food and Drug Administration (FDA) at http://www.fda.gov/consumer/updates/hib121307.html. Merck has suspended production of its Hib conjugate vaccines and does not expect to resume distribution of these vaccines until the fourth quarter of 2008. The recall of PedvaxHIB and Comvax and suspens...

CDC Recommends Deferring Hib Booster Shots in Light of Vaccine Shortage

MedPage Today Pediatrics — Thu, 20 Dec 2007 22:16:17 +0100

ATLANTA -- In the wake of the recall of a million doses of Haemophilus influenzae type B (Hib) vaccine, the CDC has asked physicians to delay booster vaccinations for most children. (Source: MedPage Today Pediatrics)

CDC Defers Hib Vaccine For Children Due To Supply Problems

Infectious Diseases / Bacteria / Viruses News From Medical News Today — Thu, 20 Dec 2007 08:00:00 +0100

The US Centers for Disease Control and Prevention (CDC), has asked doctors to defer the final booster dose of the childhood Haemophilus influenzae type b vaccine (Hib b vaccine) because of a possible problem with supplies.However, children at high risk of Hib, which causes serious bacterial infections, including meningitis and pneumonia, should continue to receive the booster shot which is given at age 12 to 15 months. [click link for full article] (Source: Infectious Diseases / Bacteria / Viruses News From Medical News Today)

Restraint Urged for Hib Vaccine

WSJ.com: Health — Thu, 20 Dec 2007 05:22:00 +0100

Federal health officials said doctors should temporarily stop giving children the final booster shot of the Hib vaccine because of expected shortages caused by a recall. (Source: WSJ.com: Health)

CDC, AAFP, Others Release Interim Hib Vaccine Recommendations

AAFP Clinical Care and Research — Wed, 19 Dec 2007 23:05:00 +0100

In response to a looming shortage of Haemophilus influenzae type b, or Hib, conjugate vaccine, the CDC, in consultation with its Advisory Committee on Immunization Practices, or ACIP; the AAFP; and the American Academy of Pediatrics, is recommending that physicians and other vaccine providers temporarily defer the routine Hib vaccine booster dose typically administered at age 12-15 months except for children in specific high-risk groups. CDC officials are encouraging health care professionals to track children in whom the booster dose is deferred so they can be recalled for immunization when the current Hib vaccine supply disruption improves. (Source: AAFP Clinical Care and Research)

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CDC Tweaks Kids' Vaccine Recommendation

WebMD Health — Wed, 19 Dec 2007 05:00:00 +0100

The CDC has suspended its advice that kids age 12-15 months get booster shots of the Hib vaccine due a recall-related Hib vaccine shortage. (Source: WebMD Health)

No vaccine worries for UAE

Healthcare — Sat, 15 Dec 2007 03:48:26 +0100

The decision last week by pharmaceutical firm Merck and Company to recall haemophilus influenzae type B (HiB) vaccines in the US due to contamination concerns, will not have any impact on supplies in the UAE, reported Gulf News. The vaccines guard against meningitis, pneumonia and other infections but the UAE receives its drugs from another pharmaceutical company, Sanofi-Aventis. The UAE also has enough supplies of these vaccines to last a year. (Source: Healthcare)

Merck Recalls 1 Million Doses of Childhood Hib Vaccine

Medscape Today Headlines — Fri, 14 Dec 2007 16:58:40 +0100

Healthcare professionals advised against using potentially contaminated vaccines. Medscape Medical News (Source: Medscape Today Headlines)

Merck Recalls 1 Million Hib Vaccine Doses

AAFP Clinical Care and Research — Thu, 13 Dec 2007 21:05:00 +0100

Vaccine manufacturer Merck & Co. Inc. yesterday announced a voluntary recall involving two vaccine products containing its Haemophilus influenzae type b, or Hib, conjugate vaccine because of a potential for contamination of these products. The recall covers 10 lots of Merck's Hib conjugate vaccine, sold as PedvaxHIB, and two lots of its combination Hib/hepatitis B vaccine, COMVAX. In all, about 1 million doses of vaccine have been recalled. (Source: AAFP Clinical Care and Research)

Effects of feeding probiotics during weaning on infections and antibody responses to diphtheria, tetanus and Hib vaccines

Pediatric Allergy and Immunology — Thu, 13 Dec 2007 00:28:41 +0100

Pediatric Allergy and Immunology, Volume 0, Issue 0, Page ???, OnlineEarly Articles. West CE, Gothefors L, Granström M, Käyhty H, Hammarström M-L, Hernell O. Effects of feeding probiotics during weaning on infections and antibody responses to diphtheria, tetanus and Hib vaccines.Pediatr Allergy Immunol 2007 0: 00–00. © 2007 The Authors ... (Source: Pediatric Allergy and Immunology)

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Merck Recalls Million Doses of Hib Vaccine

MedPage Today Public Health — Wed, 12 Dec 2007 22:51:08 +0100

ATLANTA -- Merck has issued a voluntary recall of one million doses of its Haemophilus influenzae type b vaccine, an action that the CDC said does not threaten public health but will cause a serious vaccine shortage. (Source: MedPage Today Public Health)

Merck Recalls Childhood Vaccine

WSJ.com: Health — Wed, 12 Dec 2007 22:51:00 +0100

Merck is recalling a million doses of a childhood vaccine after sterilization problems were reported in a Pennsylvania factory. The company said it wasn't aware of any harm to children who received the Hib vaccine. (Source: WSJ.com: Health)

1M Doses Of Hib Vaccine For Kids Recalled

WDSU.com - Health — Wed, 12 Dec 2007 22:19:24 +0100

A vaccine for meningitis and pneumonia could have a sterlization problem, the maker says. (Source: WDSU.com - Health)

1 Million Doses of Hib Vaccine Recalled

WebMD Health — Wed, 12 Dec 2007 05:00:00 +0100

The drug company Merck is recalling about 1 million doses of its haemophilus influenzae vaccine. (Source: WebMD Health)

CDC and FDA Advise Public of Vaccine Recall

Centers for Disease Control and Prevention — Wed, 12 Dec 2007 05:00:00 +0100

Telebriefing to discuss Merck(c) Haemophilus influenzae type b (Hib) vaccine recall (Source: Centers for Disease Control and Prevention)

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CDC and FDA Advise Public of Vaccine Recall

Centers for Disease Control and Prevention — Wed, 12 Dec 2007 00:00:00 +0100

Telebriefing to discuss Merck(c) Haemophilus influenzae type b (Hib) vaccine recall (Source: Centers for Disease Control and Prevention)

CDC and FDA Advise Public of Vaccine Recall

Centers for Disease Control and Prevention — Wed, 12 Dec 2007 00:00:00 +0100

Telebriefing to discuss Merck(c) Haemophilus influenzae type b (Hib) vaccine recall (Source: Centers for Disease Control and Prevention)

Epidemiology and outcomes of bacterial meningitis in Mexican children: 10-year experience (1993-2003).

International Journal of Infectious Diseases — Thu, 06 Dec 2007 05:00:00 +0100

CONCLUSIONS: In our hospital, acute bacterial meningitis remains a severe disease with important sequelae and mortality. The incidence of Hib meningitis cases has declined since the introduction of the Hib vaccine. However, S. pneumoniae persists as an important cause of bacterial meningitis, highlighting the need for the implementation of vaccination policies against this pathogen. PMID: 18068385 [PubMed - as supplied by publisher] (Source: International Journal of Infectious Diseases)

Merck Temporarily Unable to Ship Hib Vaccine

AAFP Clinical Care and Research — Fri, 16 Nov 2007 21:30:00 +0100

Merck & Co. Inc. recently notified the CDC that its Haemophilus influenzae type b conjugate vaccine, sold as PedvaxHIB, currently is unavailable for shipment. Merck said it anticipates the vaccine, which is indicated for routine immunization against invasive disease caused by H. influenzae type b in infants and children ages 2-71 months, will become available again sometime in the first quarter of 2008; the exact timing will depend on resolution of a manufacturing issue. (Source: AAFP Clinical Care and Research)