MedWorm: MMR (Measles,Mumps,Rubella) Vaccine

Development of a bead-based multiplex immunoassay for the simultaneously quantitative detection of IgG serum antibodies against Measles, Mumps, Rubella and Varicella Zoster.

Clinical and Vaccine Immunology — Wed, 11 Jan 2012 05:00:00 +0100

In conclusion, the MMRV multiplex assay is a good alternative for the conventional ELISAs and suitable for use in serosurveillance and vaccine studies. PMID: 22237896 [PubMed - as supplied by publisher] (Source: Clinical and Vaccine Immunology)

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Concomitant MMRV, Prevnar Safe for Healthy InfantsConcomitant MMRV, Prevnar Safe for Healthy Infants

Medscape Pediatrics Headlines — Wed, 07 Dec 2011 03:52:35 +0100

Administering a child's first dose of the measles, mumps, rubella and varicella (MMRV) vaccine together with the pneumococcal vaccine is "highly immunogenic and generally well tolerated." Reuters Health Information (Source: Medscape Pediatrics Headlines)

Concomitant MMRV, Prevnar safe for healthy infants

Modern Medicine — Mon, 05 Dec 2011 05:00:00 +0100

NEW YORK (Reuters Health) - Administering a child's first dose of the measles, mumps, rubella and varicella (MMRV) vaccine together with the pneumococcal vaccine is "highly immunogenic and generally well tolerated," a new study shows. (Source: Modern Medicine)

Immunogenicity and Safety of MMRV and PCV-7 Administered Concomitantly in Healthy Children

PEDIATRICS — Thu, 01 Dec 2011 05:00:00 +0100

CONCLUSIONS: Concomitant administration of the MMRV and PCV-7 is highly immunogenic and generally well tolerated. Similar immune responses between the groups support concomitant administration of the MMRV and PCV-7 to healthy children 12 to 15 months of age. (Source: PEDIATRICS)

Vaccines in the News

About.com Pediatrics — Mon, 28 Nov 2011 19:10:28 +0100

It is not unusual for vaccines to make the news, but today there was news on a lot of different vaccine topics from the American Academy of Pediatrics. One study, "Immunogenicity and Safety of MMRV and PCV-7 Administered Concomitantly in Healthy Children," should reassure many parents who are worried about vaccines. The study, which will be printed in the December issue of Pediatrics, found that it was safe to give toddlers ProQuad (a vaccine that combines MMR and Varivax) and Prevnar at the same time. The researchers found this combination of shots to be well tolerated and "highly immunogenic" as just over 1,000 children were followed for 28 days after they received the shots together or six weeks apart....Read Full Post (Source: About.com Pediatrics)

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Antibody persistence for 3 years following two doses of tetravalent measles–mumps–rubella–varicella vaccine in healthy children

European Journal of Pediatrics — Tue, 20 Sep 2011 15:46:10 +0100

Conclusion: Immunogenicity of the combined MMRV vaccine was sustained 3 years post-vaccination. (208136/041/NCT00406211). Content Type Journal ArticleCategory Original PaperPages 1-8DOI 10.1007/s00431-011-1569-4Authors Markus Knuf, Children’s Department of Pediatrics, University Medicine Hospital, Johannes Gutenberg-University, Langenbeckstrasse 1, 55101 Mainz, GermanyFred Zepp, Children’s Department of Pediatrics, University Medicine Hospital, Johannes Gutenberg-University, Langenbeckstrasse 1, 55101 Mainz, GermanyKlaus Helm, Pediatric Office, Detmold, GermanyHartwig Maurer, Pediatric Office, Salzburg, AustriaAlbrecht Prieler, Pediatric Office, Salzburg, AustriaDorothee Kieninger-Baum, Children’s Department of Pediatrics, University Medicine Hospital, Johannes Gutenberg-...

Prevention of Varicella: Update of Recommendations for Use of Quadrivalent and Monovalent Varicella Vaccines in Children

PEDIATRICS — Wed, 31 Aug 2011 23:00:00 +0100

Two varicella-containing vaccines are licensed for use in the United States: monovalent varicella vaccine (Varivax [Merck & Co, Inc, West Point, PA]) and quadrivalent measles-mumps-rubella-varicella vaccine (MMRV) (ProQuad [Merck & Co, Inc]). It is estimated from postlicensure data that after vaccination at 12 through 23 months of age, 7 to 9 febrile seizures occur per 10 000 children who receive the MMRV, and 3 to 4 febrile seizures occur per 10 000 children who receive the measles-mumps-rubella (MMR) and varicella vaccines administered concurrently but at separate sites. Thus, 1 additional febrile seizure is expected to occur per approximately 2300 to 2600 children 12 to 23 months old vaccinated with the MMRV, when compared with separate MMR and varicella vaccine administration. ...

Tetravalent meningococcal serogroups A, C, W-135 and Y conjugate vaccine is well tolerated and immunogenic when co-administered with measles-mumps-rubella-varicella vaccine during the second year of life: An open, randomized controlled trial.

Vaccine — Fri, 25 Mar 2011 00:00:00 +0100

This study has been registered at www.clinicaltrials.gov NCT00474266. PMID: 21443965 [PubMed - as supplied by publisher] (Source: Vaccine)

New Vaccine Recommendations Offer Combined Benefits While Saving Children Two Extra Shots

Health News from Medical News Today — Thu, 28 Oct 2010 08:00:00 +0100

Last week, Canada's National Advisory Committee on Immunization (NACI) issued several statements including its recommendations for the use of PRIORIX-TETRA™; the first, and at present, the only measles-mumps-rubella-varicella (MMRV) combivalent vaccine authorized for use in Canada. In a simultaneously issued statement, NACI has now recommended that all children receive a second dose of varicella vaccine at either 18 months or 4-6 years of age, which can be given in combination with the scheduled second dose of the Measles-Mumps-Rubella vaccine. Manufactured by GlaxoSmithKline Inc... (Source: Health News from Medical News Today)

MMRV and Seizures [Health Agencies Update]

JAMA — Tue, 24 Aug 2010 19:50:43 +0100

(Source: JAMA)

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MMRV vaccine elevates risk of febrile seizures

Reactions — Fri, 23 Jul 2010 02:06:15 +0100

(Source: Reactions)

Detection of IgG-class antibodies to measles, mumps, rubella, and varicella-zoster virus using a multiplex bead immunoassay

Diagnostic Microbiology and Infectious Disease — Wed, 21 Jul 2010 07:46:41 +0100

This study evaluated the performance of the MMRV IgG AtheNA Multi-Lyte® assay using nonclinically characterized serum specimens submitted to our laboratory for routine MMRV IgG testing. Mumps (n = 492) or rubella (n = 500) IgG were initially tested by enzyme-linked fluorescent antibody (ELFA), whereas measles (n = 494) or varicella (n = 497) were analyzed by EIA. Each sample was also tested by the AtheNA Multi-Lyte assay. Discordant results were retested by the predicate method and the multiplex assay, with further discrepancies being arbitrated by a third test. Compared to EIA/ELFA for MMRV IgG, the AtheNA assay demonstrated an overall agreement of 97.4%, 98.2%, 97.6%, and 100%, respectively. Use of this multiplex assay allows for the simultaneous detection of MMRV IgG, potentially decre...

Measles-Mumps-Rubella-Varicella Combination Vaccine and the Risk of Febrile Seizures

PEDIATRICS — Thu, 01 Jul 2010 15:02:54 +0100

CONCLUSIONS: Among 12- to 23-month-olds who received their first dose of measles-containing vaccine, fever and seizure were elevated 7 to 10 days after vaccination. Vaccination with MMRV results in 1 additional febrile seizure for every 2300 doses given instead of separate MMR + varicella vaccines. Providers who recommend MMRV should communicate to parents that it increases the risk of fever and seizure over that already associated with measles-containing vaccines. (Source: PEDIATRICS)

Combo MMRV Vaccine Tied to Higher Febrile Seizure Risk

Pediatric News — Wed, 30 Jun 2010 23:00:00 +0100

Major Finding: In the 7- to10-day postvaccination period, use of MMRV was associated with 4.3 additional febrile seizures per 10,000 doses, compared with separate administration of MMR and varicella vaccine. (Source: Pediatric News)

Combination MMRV vaccine linked with two-fold risk of seizures, study finds

ScienceDaily Headlines — Wed, 30 Jun 2010 03:00:00 +0100

The combination vaccine for measles, mumps, rubella and chickenpox is associated with double the risk of febrile seizures for 1- to 2-year-old children compared with same-day administration of the separate vaccine for measles, mumps and rubella and the varicella vaccine for chicken pox. Funded by the US Centers for Disease Control, the study analyzed 459,000 children 1 to 2 years old from numerous health systems across the US receiving their first dose of measles-containing vaccine. (Source: ScienceDaily Headlines)

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Electronic Health Records Study Of 459,000 Children Sparked New CDC Recommendations Regarding Vaccine And Link To Seizures

ICMCC: The International Council on Medical and Care Compunetics — Tue, 29 Jun 2010 20:52:26 +0100

“The combination vaccine for measles, mumps, rubella and chickenpox (MMRV) is associated with double the risk of febrile seizures for 1- to 2-year-old children compared with same-day administration of the separate vaccine for MMR (measles, mumps, rubella) and the varicella (V) vaccine for chicken pox, according to a Kaiser Permanente Division of Research study appearing [...] (Source: ICMCC: The International Council on Medical and Care Compunetics)

Vaccine Safety Data Show Risk Levels For Febrile Seizures After MMRV Vaccine

Health News from Medical News Today — Tue, 29 Jun 2010 10:00:00 +0100

Researchers found a higher risk of febrile seizures 7 to 10 days after vaccination with Measles-Mumps-Rubella-Varicella combination vaccine (MMRV) compared to when MMR and varicella vaccines were given separately. Febrile seizures are seizures caused by a sudden spike in body temperature, and they are generally harmless... (Source: Health News from Medical News Today)

Electronic Health Records Study Of 459,000 Children Sparked New CDC Recommendations Regarding Vaccine And Link To Seizures

Health News from Medical News Today — Tue, 29 Jun 2010 10:00:00 +0100

The combination vaccine for measles, mumps, rubella and chickenpox (MMRV) is associated with double the risk of febrile seizures for 1- to 2-year-old children compared with same-day administration of the separate vaccine for MMR (measles, mumps, rubella) and the varicella (V) vaccine for chicken pox, according to a Kaiser Permanente Division of Research study appearing online in the journal Pediatrics. A febrile seizure is a brief, fever-related convulsion but it does not lead to epilepsy or seizure disorders, researchers explained. Funded by the U.S... (Source: Health News from Medical News Today)

Seizure Risk Rises With MMRV Vaccine

eMedicineHealth.com — Tue, 29 Jun 2010 07:00:00 +0100

(Source: eMedicineHealth.com)

Childhood Combo-Vaccine Raises Risk of Seizures

Medical Headlines From Ivanhoe.com — Tue, 29 Jun 2010 05:00:00 +0100

(Ivanhoe Newswire) -- MMRV, the combination vaccine for measles, mumps, rubella and chickenpox, may double the risk of febrile seizures in 1- to 2-year-old children, compared with same-day administration of the vaccines as separate injections. (Source: Medical Headlines From Ivanhoe.com)

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MMRV Vaccine Ups Fever and Seizure Risk

Modern Medicine — Mon, 28 Jun 2010 23:00:00 +0100

Measles-mumps-rubella-varicella vaccination is associated with an increased risk of fever and seizure in young children, above that already associated with measles-containing vaccines, according to research published online June 29 in Pediatrics, confirming preliminary evidence from a previous study. (Source: Modern Medicine)

MMRV Doubles Risk for Febrile Seizures 7 to 10 Days After Vaccination

Medscape Today Headlines — Mon, 28 Jun 2010 20:59:52 +0100

A new study suggests the vaccine causes 1 additional seizure for every 2300 doses with the combination vaccine, so the risk is still low, researchers note. Medscape Medical News (Source: Medscape Today Headlines)

Seizure Risk Rises With 4-in-1 Vaccine

WebMD Health — Mon, 28 Jun 2010 18:36:52 +0100

The risk of fever-related seizures in infants nearly doubles with the 4-in-1 measles-mumps-rubella-chickenpox vaccine (MMRV) compared to separate injections with the measles-mumps-rubella (MMR) vaccine and the chickenpox vaccine, according to a new study. (Source: WebMD Health)

Electronic Medical Records Strengthen Vaccine Safety Monitoring In Seizure Study

ICMCC: The International Council on Medical and Care Compunetics — Mon, 28 Jun 2010 17:01:53 +0100

“Intelligent use of electronic health records—even those collected from multiple health systems—can alert providers to harmful medical practices. That’s how Kaiser Permanente’s analysis of 459,000 pediatric health records revealed that young children who received the combo MMRV (measles, mumps, rubella, varicella) vaccine experienced twice the rate of febrile seizures as did children who received two separate [...] (Source: ICMCC: The International Council on Medical and Care Compunetics)

MMRV vaccine associated with 2-fold risk of seizures

Medicineworld.org: New Article Alert — Mon, 28 Jun 2010 13:36:33 +0100

The combination vaccine for measles, mumps, rubella and chickenpox (MMRV) is linked to double the risk of febrile seizures for 1- to 2-year-old children compared with same-day administration of the separate vaccine for MMR (measles, mumps, rubella) and the varicella (V) vaccine for chicken pox, as per a Kaiser Permanente Division of Research study appearing online in the journal Pediatrics A febrile seizure is a brief, fever-related convulsion but it does not lead to epilepsy or seizure disorders, scientists explained........ (Source: Medicineworld.org: New Article Alert)

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2 shots may be better than one for measles, mumps, rubella and chicken pox

Los Angeles Times - Science — Mon, 28 Jun 2010 04:11:00 +0100

A single vaccine of MMRV doubles the risk of fever-related seizures in children, a study finds. Children who receive a single vaccine that protects against measles, mumps, rubella and chicken pox appear to have an increased risk of fever-related seizures in the days after the shot than do children who receive two separate vaccinations. (Source: Los Angeles Times - Science)

Combination MMRV vaccine linked with 2-fold risk of seizures

EurekAlert! - Medicine and Health — Mon, 28 Jun 2010 04:00:00 +0100

(Kaiser Permanente) The combination vaccine for measles, mumps, rubella and chickenpox is associated with double the risk of febrile seizures for 1- to 2-year-old children compared with same-day administration of the separate vaccine for measles, mumps and rubella and the varicella vaccine for chicken pox. Funded by the US Centers for Disease Control, the study analyzed 459,000 children 1 to 2 years old from numerous health systems across the US receiving their first dose of measles-containing vaccine. (Source: EurekAlert! - Medicine and Health)

Should We Consider Giving MMR Earlier?

Pediatric News — Mon, 31 May 2010 23:00:00 +0100

DR. HARRISON is a professor of pediatrics and pediatric infectious diseases at Children's Mercy Hospitals and Clinics, Kansas City, Mo. Dr. Harrison disclosed he has received grant support from GlaxoSmithKline and Sanofi Pasteur Inc. for research on MMR and MMRV vaccines within the past 3 years. E-mail Dr. Harrison at pdnews@elsevier.com. (Source: Pediatric News)

Bio-Rad Launches A Measles, Mumps, Rubella, And Varicella-Zoster Virus IgG Kit For Its BioPlex 2200 System

Health News from Medical News Today — Tue, 25 May 2010 07:00:00 +0100

Bio-Rad Laboratories, Inc. (NYSE: BIO) and (NYSE: BIO.B), a multinational manufacturer and distributor of life science research and clinical diagnostic products, announced the launch of the BioPlex® 2200 MMRV IgG kit for use on the company's BioPlex® 2200 system. The MMRV IgG kit (measles; mumps; rubella; and the varicella-zoster virus, which is commonly known as chicken pox) provides simultaneous results for the four tests that are commonly ordered together to determine a patient's susceptibility to MMRV... (Source: Health News from Medical News Today)

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CDC Updates Recommendations for MMRV Vaccination

AAFP Clinical Care and Research — Wed, 12 May 2010 16:45:00 +0100

Physicians who provide care for children should be aware that the CDC has published updated recommendations for vaccination against measles, mumps, rubella and varicella. The recommendations, which have been adopted by the AAFP, offer clinicians insight into the preferred use of combination measles, mumps, rubella and varicella, or MMRV, vaccine versus use of MMR vaccine plus varicella vaccine. (Source: AAFP Clinical Care and Research)

ACIP Issues New Guidelines for Use of Combination Measles, Mumps, Rubella, Varicella Vaccine

Medscape Today Headlines — Tue, 11 May 2010 20:04:04 +0100

A MMWR report offers new recommendations for use of the MMRV vaccine adopted in June 2009 by the Centers for Disease Control and Prevention Advisory Committee on Immunization Practices. Medscape Medical News (Source: Medscape Today Headlines)

Use of combination measles, mumps, rubella, and varicella vaccine: recommendations of the Advisory Committee on Immunization Practices (ACIP).

MMWR Recomm Rep — Thu, 06 May 2010 23:00:00 +0100

This report presents new recommendations adopted in June 2009 by CDC's Advisory Committee on Immunization Practices (ACIP) regarding use of the combination measles, mumps, rubella, and varicella vaccine (MMRV, ProQuad, Merck & Co., Inc.). MMRV vaccine was licensed in the United States in September 2005 and may be used instead of measles, mumps, rubella vaccine (MMR, M-M-RII, Merck & Co., Inc.) and varicella vaccine (VARIVAX, Merck & Co., Inc.) to implement the recommended 2-dose vaccine schedule for prevention of measles, mumps, rubella, and varicella among children aged 12 months-12 years. At the time of its licensure, use of MMRV vaccine was preferred for both the first and second doses over separate injections of equivalent component vaccines (MMR vaccine and varicella vacci...

Safety, immunogenicity and immediate pain of intramuscular versus subcutaneous administration of a measles–mumps–rubella–varicella vaccine to children aged 11–21 months

European Journal of Pediatrics — Thu, 11 Feb 2010 11:48:10 +0100

This study compared intramuscular and subcutaneous administration of two doses of measles–mumps–rubella–varicella (MMRV) combination vaccine (Priorix-Tetra™, GlaxoSmithKline Biologicals) in children. Healthy children (N = 328) were randomised to receive MMRV either intramuscularly or subcutaneously. Reactogenicity was similar between treatment groups for immediate vaccination pain, vaccination site pain, redness and incidence of fever and rashes. Slightly less vaccination site swelling occurred during days 0–3 of the post-vaccination period after intramuscular administration. Seroconversion rates for all components, 42–56 days post-dose 2, ranged from 99.3% to 100% in the intramuscular group and from 98.6% to 100% in the subcutaneous. Cell-mediated immunity data s...

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ACIP, AAP support choice of MMRV or separate MMR, varicella vaccines [NEWS AND FEATURES]

AAP News — Fri, 01 Jan 2010 18:01:17 +0100

(Source: AAP News)

A combined measles, mumps, rubella and varicella vaccine (Priorix-Tetra): Immunogenicity and safety profile.

Vaccine — Wed, 05 Aug 2009 23:00:00 +0100

Authors: Czajka H, Schuster V, Zepp F, Esposito S, Douha M, Willems P Priorix-Tetra (GlaxoSmithKline Biologicals) is a combined measles, mumps, rubella and varicella (MMRV) vaccine. Eight studies involving more than 3000 children were reviewed. Compared with co-administration of MMR (Priorix) and varicella (Varilrix) vaccines, the MMRV vaccine showed: similar immunogenicity, with immunity shown up to 3 years post-vaccination; a higher rate of fever after the first dose; a slight increase in mild local reactions after the second dose. This MMRV vaccine can be used either as a two-dose vaccine or as a second dose in children primed with separate MMR and/or varicella vaccines, offering a convenient way to introduce varicella vaccination into routine vaccination programmes. PMID: 19665...

ACIP says either MMR or MMRV is okay

Modern Medicine Contemporary Pediatrics — Tue, 30 Jun 2009 23:00:00 +0100

Two shots, or one? After a lot of study, the immunization division of the CDC say it?s up to you. (Source: Modern Medicine Contemporary Pediatrics)

MMRV Is Favored for Second Dose, Not for First

Pediatric News — Tue, 30 Jun 2009 23:00:00 +0100

ATLANTA — The Centers for Disease Control and Prevention's vaccine advisory panel recommended the use of either the combination measles-mumps-rubella-varicella vaccine or the separate MMR and varicella vaccines for children at 12–15 months of age, but to retain a preference for the MMRV vaccine for the second dose given at 4–6 years of age. (Source: Pediatric News)

Varicella vaccination in Europe - taking the practical approach

BMC Medicine — Thu, 28 May 2009 04:00:00 +0100

Varicella is a common viral disease affecting almost the entire birth cohort. Although usually self-limiting, some cases of varicella can be serious, with 2 to 6% of cases attending a general practice resulting in complications. The hospitalisation rate for varicella in Europe ranges from 1.3 to 4.5 per 100,000 population/year and up to 10.1% of hospitalised patients report permanent or possible permanent sequelae (for example, scarring or ataxia). However, in many countries the epidemiology of varicella remains largely unknown or incomplete.In countries where routine childhood vaccination against varicella has been implemented, it has had a positive effect on disease prevention and control. Furthermore, mathematical models indicate that this intervention strategy may provide economic bene...

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Knowledge Gaps Wide On MMRV Vaccine

Family Practice News — Fri, 15 May 2009 04:00:00 +0100

BALTIMORE — In a survey, just 26% of family physicians, compared with 71% of pediatricians, were aware of the known link between febrile seizure and the combination measles, mumps, rubella, and varicella vaccine in children aged 12-15 months. (Source: Family Practice News)

MMRV Vaccine-Febrile Seizure Link Eyed

Pediatric News — Mon, 01 Dec 2008 05:00:00 +0100

ATLANTA — The available evidence is insufficient for concluding whether children receiving the first dose of the combined measles, mumps, rubella, and varicella vaccine have an overall increased risk for febrile seizures within 30 days of vaccination, according to the MMRV vaccine safety working group of the Centers for Disease Control and Prevention's Advisory Committee on Immunization Practices. (Source: Pediatric News)

Immunogenicity and safety of measles-mumps-rubella-varicella (MMRV) vaccine followed by one dose of varicella vaccine in children aged 15 months-2 years or 2-6 years primed with measles-mumps-rubella (MMR) vaccine.

Vaccine — Mon, 10 Nov 2008 05:00:00 +0100

Authors: Gillet Y, Steri GC, Behre U, Arsène JP, Lanse X, Helm K, Esposito S, Meister N, Desole MG, Douha M, Willems P In this open, randomized, comparative study (105908/NCT00353288), 458 age-stratified children (15 months-2 years and 2-6 years) previously primed with MMR received one dose of either a combined MMRV vaccine (Priorix-Tetratrade mark, MMRV group) or concomitant MMR and varicella vaccines (Priorixtrade mark and Varilrixtrade mark, MMR+V group), followed 42-56 days later by another dose of varicella vaccine (Varilrixtrade mark) in both groups. Post-vaccination measles, mumps and rubella seropositivity rates and antibody geometric mean titers (GMTs) were high (99.5% for anti-measles and 100% for anti-mumps and anti-rubella) in both vaccine groups. In the two age strata...

The Epidemiology of Varicella Zoster Virus Infection in Italy

BMC Public Health - Latest articles — Mon, 27 Oct 2008 04:00:00 +0100

Conclusions: The results of this study can contribute to evaluating the options for varicella vaccination. It is possible that in a few years, in all Italian Regions, there will exist the conditions necessary for implementing a mass vaccination campaign and that the large-scale availability of MMRV tetravalent vaccines will facilitate mass vaccination. (Source: BMC Public Health - Latest articles)

Live attenuated measles, mumps, rubella, and varicella zoster virus vaccine (Priorix-Tetra).

Paediatric Drugs — Sat, 04 Oct 2008 15:16:20 +0100

Authors: Dhillon S, Curran MP The live attenuated tetravalent vaccine against measles, mumps, rubella, and varicella zoster viruses (MMRV) is a combination of the measles, mumps, and rubella (MMR) vaccine and the varicella zoster virus vaccine. The immunogenicity after each dose of a two-dose vaccination course of MMRV vaccine was generally similar to that of two doses of separately administered MMR plus varicella zoster vaccines, or a single dose of separately administered MMR plus varicella zoster vaccines followed by a dose of MMR vaccine, in infants aged 9-24 months. In infants aged 9-24 months administered a two-dose course of MMRV vaccine, geometric mean titers for antibodies against all vaccine antigens increased after the second dose relative to the first dose, with the increas...

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Measles-Mumps-Rubella-Varicella (MMRV) Vaccine Effective Alone or in Combination

Medscape PublicHealth Headlines — Sun, 25 May 2008 20:04:08 +0100

GlaxoSmithKline's MMR-varicella vaccine (Priorix-TetraTM) is safe and produces adequate protection when given either alone or in combination with other childhood vaccines, according to researchers who presented their data here at the 26th Annual Meeting of the European Society for Paediatric Infectious Diseases. Reuters Health Information (Source: Medscape PublicHealth Headlines)

FROM THE CENTERS FOR DISEASE CONTROL AND PREVENTION: Update: Recommendations From the Advisory Committee on Immunization Practices (ACIP) Regarding Administration of Combination MMRV Vaccine

JAMA — Tue, 15 Apr 2008 04:00:00 +0100

(Source: JAMA)

[NEWS AND FEATURES] Experts no longer prefer MMRV over separate shots

AAP News — Tue, 01 Apr 2008 04:00:00 +0100

(Source: AAP News)

Government Issues Note On Risk Of Quad Vaccine Shot

LexisNexis® Mealey's™ Thimerosal & Vaccines Legal News — Fri, 21 Mar 2008 19:08:12 +0100

ATLANTA - An apparent doubled risk of febrile seizures has prompted the Advisory Committee on Immunization Practices (ACIP) of the U.S. Centers for Disease Control to downgrade Merck & Co.'s ProQuad quadrivalent measles-mumps-rubella-varicella (MMRV) vaccine from the preferred option to an even footing with the older MMR plus a separate varicella injection. Full story on lexis.com (Source: LexisNexis® Mealey's™ Thimerosal & Vaccines Legal News)

Guidelines Updated for Administration of Combination MMRV Vaccine

Medscape Pathology Headlines — Tue, 18 Mar 2008 18:03:12 +0100

The Advisory Committee on Immunization Practices no longer prefers administering combination measles, mumps, rubella, and varicella vaccine vs separate injections of equivalent component vaccines. Medscape Medical News (Source: Medscape Pathology Headlines)

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U.S. Health Officials Back Off Preference for New MMRV Vaccine

MedicineNet Kids Health General — Fri, 14 Mar 2008 07:00:00 +0100

Title: U.S. Health Officials Back Off Preference for New MMRV VaccineCategory: Health NewsCreated: 3/14/2008 2:00:00 AMLast Editorial Review: 3/14/2008 (Source: MedicineNet Kids Health General)

1) General recommendations on immunization: recommendations of the Advisory Committee on Immunization Practices (ACIP). 2) Update: recommendations from the Advisory Committee on Immunization Practices (ACIP) regarding administration of combination MMRV vaccine.

National Guideline Clearinghouse (NGC) — Fri, 14 Mar 2008 05:00:00 +0100

(Source: National Guideline Clearinghouse (NGC))

1) Prevention of varicella: recommendations of the Advisory Committee on Immunization Practices (ACIP). 2) Update: recommendations from the Advisory Committee on Immunization Practices (ACIP) regarding administration of combination MMRV vaccine.

National Guideline Clearinghouse (NGC) — Fri, 14 Mar 2008 05:00:00 +0100

(Source: National Guideline Clearinghouse (NGC))

Update: recommendations from the Advisory Committee on Immunization Practices (ACIP) regarding administration of combination MMRV vaccine.

MMWR Morb Mortal Wkl... — Fri, 14 Mar 2008 04:00:00 +0100

This report summarizes current knowledge regarding the risk for febrile seizures after MMRV vaccination and presents updated ACIP recommendations that were issued after presentation of the new information. These updated recommendations remove ACIP's previous preference for administering combination MMRV vaccine over separate injections of equivalent component vaccines (i.e., measles, mumps, and rubella [MMR] vaccine and varicella vaccine). PMID: 18340332 [PubMed - in process] (Source: MMWR Morb Mortal Wkl...)

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Update: Recommendations from the Advisory Committee on Immunization Practices (ACIP) Regarding Administration of Combination MMRV Vaccine

CDC — Thu, 13 Mar 2008 19:12:39 +0100

(Source: CDC)

Universal two-dose MMRV vax a viable prospect in Germany.

PharmacoEconomics & Outcomes News — Tue, 04 Dec 2007 01:29:57 +0100

Page: 8 (Source: PharmacoEconomics & Outcomes News)

Universal two-dose MMRV vax a viable prospect in Germany

Inpharma — Mon, 03 Dec 2007 12:47:40 +0100

(Source: Inpharma)

Merck Apologizes for Vaccine Shortages, Delays

AAFP Clinical Care and Research — Wed, 29 Aug 2007 20:35:00 +0100

Pharmaceutical manufacturer Merck & Co. Inc. has issued a letter apologizing to its customers for "recent vaccine supply interruptions" that have resulted in shortages and shipping delays involving some vaccines frequently administered by family physicians. Those vaccines are Merck's measles-mumps-rubella-varicella vaccine, or MMRV, sold as ProQuad, and the adult and pediatric formulations of its hepatitis A vaccine, inactivated, sold as VAQTA. (Source: AAFP Clinical Care and Research)

Safety and Immunogenicity of Early Vaccination with Two Doses of Tetravalent Measles-Mumps-Rubella-Varicella (MMRV) Vaccine in Healthy Children from 9 Months of Age

Infection — Tue, 21 Aug 2007 06:47:54 +0100

Conclusion Early vaccination with two doses of this experimental MMRV vaccine at 9 and 12 months of age was well-tolerated and at least as immunogenic as two doses of separate licensed MMR and varicella vaccines. Content TypeJournal Article JournalInfectionOnline ISSN 1439-0973Print ISSN 0300-8126 (Source: Infection)

[NEWS AND FEATURES] Supply difficulties expected with MMRV

AAP News — Fri, 01 Jun 2007 04:00:00 +0100

(Source: AAP News)

Immunogenicity and safety of a tetravalent measles-mumps-rubella-varicella vaccine co-administered with a booster dose of a combined diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus- Haemophilus influenzae type b conjugate vaccine in healthy children aged 12–23 months

European Journal of Pediatrics — Thu, 31 May 2007 17:28:02 +0100

This study was undertaken to assess the co-administration of an experimental measles-mumps-rubella-varicella vaccine (MMRV, GlaxoSmithKline Biologicals) with a combined diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus-Haemophilus influenzae type b conjugate (DTPa-HBV-IPV/Hib) vaccine in healthy children. Healthy children aged 12–23 months (N = 451) were randomised to one of three parallel groups to receive one dose of MMRV vaccine co-administered with a booster dose of DTPa-HBV-IPV/Hib vaccine (co-administration group), or one dose of MMRV vaccine alone (MMRV group), or a booster dose of DTPa-HBV-IPV/Hib vaccine alone (DTPa-HBV-IPV/Hib group). No differences in seroconversion rates for measles (>95%), mumps (>80%), rubella (>99%) and varicel...

[Chickenpox: sufficient reasons for the introduction of vaccination]

Herpes — Tue, 09 Jan 2007 22:27:02 +0100

Authors: Rümke H, de Groot R The incidence of chickenpox and its complications is high enough to favour introducing varicella vaccination into the Dutch immunisation programme for children, although current Dutch figures may even underestimate the incidence. Safe and effective MMRV vaccines, in which varicella (V) vaccine is combined with measles, mumps and rubella (MMR), could well replace the MMR vaccine used at present. MMRV vaccines should be administered subcutaneously in two doses. Ten years after the introduction of varicella vaccination in the United States of America, the incidence of complications has decreased impressively. An effect on the incidence of herpes zoster has not (yet) been seen. PMID: 17205937 [PubMed - in process] (Source: Herpes)

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Assessing the introduction of universal varicella vaccination in the Netherlands.

Vaccine — Thu, 16 Nov 2006 04:48:01 +0100

Authors: Boot HJ, de Melker HE, Stolk EA, de Wit GA, Kimman TG Although varicella is seen as a benign disease in the Netherlands, about 40,000 visits to a general practitioner (GP) are made, over 200 hospital admission occur, and 2.3 persons die on average each year. Most of this burden of disease can be prevented by universal varicella childhood vaccination. Ten years after the introduction of the single-shot, single-component varicella childhood vaccination in the USA, a major reduction in hospitalization, mortality, and burden of disease has been reported. Using our recently vaccine evaluation model for the introduction of a new vaccine in our national immunization program, we have analyzed the feasibility of universal varicella vaccination by replacing the measles-mumps-rubella (MM...

Measles, rubella, mumps, and varicella seroprevalence among health care workers in Turkey: is prevaccination screening cost-effective?

American Journal of Infection Control — Wed, 01 Nov 2006 07:00:00 +0100

CONCLUSION: A policy based on obtaining the history of varicella infection from the staff and then screening the ones with negative history and vaccination of only seronegative HCWs was found to be appropriate. PMID: 17097453 [PubMed - indexed for MEDLINE] (Source: American Journal of Infection Control)

[NEWS AND FEATURES] MMRV vaccine brings changes to 12- to 15-month visit

AAP News — Fri, 28 Apr 2006 06:00:00 +0100

(No abstract is available for this citation) (Source: AAP News)