Query: 
This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. 
Subscribe to this data using MyMedWorm.
Subscribe to this data using GoogleReader.
Subscribe to this data using Bloglines.
Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors
This page shows you your search results in order of date.
596400 records returned
Prevalence, Patterns, and Persistence of Sleep Problems in the First 3 Years of Life
Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Sleep problems are common during childhood, but screening for sleep problems in the clinic setting is often cursory. Moreover, there are few longitudinal studies examining the prevalence and persistence of sleep problems in young children.
Patterns of sleep problems vary across early development, but sleep problems arising in infancy persist in 21% of children through 36 months of age. Parent response to a nonspecific query about sleep problems may overlook relevant sleep symptoms and behaviors. (Read the full article)
Source: PEDIATRICS - February 1, 2012 Category: Pediatrics Tags: Pediatrics Digest Summary Source Type: research
Interleukin-1 receptor-associated kinase-3 is a key inhibitor of inflammation in obesity and metabolic syndrome.Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
CONCLUSION: IRAK3 is a key inhibitor of inflammation in association with obesity and metabolic syndrome. Our data warrant further evaluation of IRAK3 as a diagnostic and prognostic marker, and as a target for intervention.
PMID: 22272346 [PubMed - in process]
Source: Atherosclerosis - January 31, 2012 Category: Cardiology Authors: Hulsmans M, Geeraert B, De Keyzer D, Mertens A, Lannoo M, Vanaudenaerde B, Hoylaerts M, Benhabilès N, Tsatsanis C, Mathieu C, Holvoet P Tags: PLoS One Source Type: research
Loss of regulator of g protein signaling 5 exacerbates obesity, hepatic steatosis, inflammation and insulin resistance.Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
CONCLUSIONS/SIGNIFICANCE: Our data suggest that loss of RGS5 exacerbates HF-induced obesity, hepatic steatosis, inflammation and insulin resistance.
PMID: 22272317 [PubMed - in process]
Source: Atherosclerosis - January 31, 2012 Category: Cardiology Authors: Deng W, Wang X, Xiao J, Chen K, Zhou H, Shen D, Li H, Tang Q Tags: PLoS One Source Type: research
Indicators of the atherogenic lipoprotein phenotype measured with density gradient ultracentrifugation predict changes in carotid intima-media thickness in men and women.Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
CONCLUSION: These data indicate that DGU-derived indicators of the "atherogenic lipoprotein phenotype," including increased TG-rich lipoprotein cholesterol, lower HDL-C and HDL-C subfractions, and a greater proportion of LDL-C carried by more dense LDL particles, are associated with CIMT progression in men and women at moderate risk for coronary heart disease.
PMID: 22272073 [PubMed - in process]
Source: Atherosclerosis - January 31, 2012 Category: Cardiology Authors: Maki KC, Dicklin MR, Davidson MH, Mize PD, Kulkarni KR Tags: Vasc Health Risk Manag Source Type: research
The Influence of Low and Moderate Carotid Stenosis on Neurophysiologic Status of Patients Undergoing on-pump Coronary Artery Bypass Grafting.Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Conclusion: Our results suggest that the presence of low and moderate ICA stenosis is one of the factors affecting the neurophysiologic status of CHD patients. It has been assumed that the patients with ≤50% ICA stenoses constitute a high-risk group for cerebral complications after on-pump CABG.
PMID: 22279441 [PubMed - in process]
Source: Atherosclerosis - January 31, 2012 Category: Cardiology Authors: Trubnikova O, Tarasova I, Barbarash O Tags: Front Neurol Source Type: research
Proteomic Analysis of Aortae from Human Lipoprotein(a) Transgenic Mice Shows an Early Metabolic Response Independent of Atherosclerosis.Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
CONCLUSIONS: Our study shows that human LDL and lipoprotein(a) promote changes in the expression of a unique set of arterial proteins which may be early indicators of the metabolic disturbances preceding atherosclerosis.
PMID: 22276189 [PubMed - in process]
Source: Atherosclerosis - January 31, 2012 Category: Cardiology Authors: Rodger EJ, Suetani RJ, Jones GT, Kleffmann T, Carne A, Legge M, McCormick SP Tags: PLoS One Source Type: research
Rac1 Regulates the NLRP3 Inflammasome Which Mediates IL-1beta Production in Chlamydophila pneumoniae Infected Human Mononuclear Cells.Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
In conclusion, C. pneumoniae infection of mononuclear cells stimulates IL-1β production dependent on a NLRP3 inflammasome-mediated processing of proIL-1β which is controlled by Rac1.
PMID: 22276187 [PubMed - in process]
Source: Atherosclerosis - January 31, 2012 Category: Cardiology Authors: Eitel J, Meixenberger K, van Laak C, Orlovski C, Hocke A, Schmeck B, Hippenstiel S, N'guessan PD, Suttorp N, Opitz B Tags: PLoS One Source Type: research
Macrophage Phenotype Modulation by CXCL4 in Atherosclerosis.Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Abstract
During atherogenesis, blood monocytes transmigrate into the subendothelial space and differentiate toward macrophages and foam cells. The major driver of monocyte-macrophage differentiation is macrophage colony-stimulating factor (M-CSF). M-CSF-induced macrophages are important promoters of atherogenesis as demonstrated in M-CSF and M-CSF receptor knock out mice. However, M-CSF is not the only relevant promoter of macrophage differentiation. The platelet chemokine CXCL4 also prevents monocyte apoptosis and promotes macrophage differentiation in vitro. It is secreted from activated platelets and has effects...
Source: Atherosclerosis - January 31, 2012 Category: Cardiology Authors: Gleissner CA Tags: Front Physiol Source Type: research
The Virtual Fly Brain browser and query interfaceEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
We present an online resource that provides a convenient way to study and query fly brain anatomy, expression and genetic data. We extended the newly developed BrainName nomenclature for the adult fly brain into a logically structured ontology that relates a comprehensive set of published neuron classes to the brain regions they innervate. The Virtual Fly Brain interface allows users to explore the structure of the Drosophila brain by browsing 3D images of a brain with subregions displayed as coloured overlays. An integrated query mechanism allows complex searches of underlying anatomy, cells, expression and other data fro...
Source: Bioinformatics - January 30, 2012 Category: Bioinformatics Authors: Milyaev, N., Osumi-Sutherland, D., Reeve, S., Burton, N., Baldock, R. A., Armstrong, J. D. Tags: DATABASES AND ONTOLOGIES Source Type: research
An infrastructure for ontology-based information systems in biomedicine: RICORDO case studyEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Summary: The article presents an infrastructure for supporting the semantic interoperability of biomedical resources based on the management (storing and inference-based querying) of their ontology-based annotations. This infrastructure consists of: (i) a repository to store and query ontology-based annotations; (ii) a knowledge base server with an inference engine to support the storage of and reasoning over ontologies used in the annotation of resources; (iii) a set of applications and services allowing interaction with the integrated repository and knowledge base. The infrastructure is being prototyped and developed and...
Source: Bioinformatics - January 30, 2012 Category: Bioinformatics Authors: Wimalaratne, S. M., Grenon, P., Hoehndorf, R., Gkoutos, G. V., de Bono, B. Tags: DATABASES AND ONTOLOGIES Source Type: research
Insulin resistance: Is it time for primary prevention?Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Abstract
Insulin resistance is a clinical condition characterized by a decrease in sensitivity and responsiveness to the metabolic actions of insulin, so that a given concentration of insulin produces a less-than-expected biological effect. As a result, higher levels of insulin are needed to maintain normal glucose tolerance. Hyperinsulinemia, indeed, is one of the principal characteristics of insulin resistance states. This feature is common in several pathologic conditions, such as type 2 diabetes, obesity, and dyslipidemia, and it is also a prominent component of hypertension, coronary heart disease, and atheros...
Source: Atherosclerosis - January 26, 2012 Category: Cardiology Authors: Mercurio V, Carlomagno G, Fazio V, Fazio S Tags: World J Cardiol Source Type: research
The Scientist: Jim Hansen Risks Handcuffs to Make His Research ClearEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Editor's note: Climate Query is a semi-weekly feature offered by Daily Climate, presenting short Q&A's with players large and small in the climate arena. Read others in the series at http://wwwp.dailyclimate.org/tdc-newsroom/query/climate-queries . [More]
Source: Scientific American - Official RSS Feed - January 24, 2012 Category: Science Tags: Energy & Sustainability,Society Policy,Everyday Science,Climate,Energy Sustainability,Environment,More Science Source Type: research
Automating classification of free‐text electronic health records for epidemiological studiesEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
ConclusionsAlthough a training set still needs to be created manually, text mining can help reduce the amount of manual work needed to incorporate narrative data in an epidemiological study and will make the data extraction more reproducible. An advantage of machine learning is that it is able to pick up specific language use, such as abbreviations and synonyms used by physicians. Copyright © 2012 John Wiley & Sons, Ltd.
Source: Pharmacoepidemiology and Drug Safety - January 24, 2012 Category: Drugs & Pharmacology Authors: Martijn J. SchuemieEmine SenGeert W. 't JongEva M. SoestMiriam C. SturkenboomJan A. Kors Tags: Original Report Source Type: research
Ligand Based Virtual Screening and Molecular Docking Studies to Identify the Critical Chemical Features of Potent Cathepsin D InhibitorsEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
AbstractCathepsin D (CatD) is a major component of lysosomes and plays a major role in catabolism and degenerative diseases. The quantitative structure‐activity relationship study was used to explore the critical chemical features of CatD inhibitors. Top ten hypotheses were built based on 36 known CatD inhibitors using HypoGen/Discovery Studio v2.5. The best hypothesis, Hypo1 consists of three hydrophobic, one hydrogen bond acceptor lipid, and one hydrogen bond acceptor features. The selected Hypo1 model was cross validated using Fischer’s randomization method to identify the strong correlation between experimental and...
Source: Chemical Biology and Drug Design - January 23, 2012 Category: Biology Authors: Sugunadevi SakkiahSundarapandian ThangapandianKeun Woo Lee Source Type: research
Visually defining and querying consistent multi-granular clinical temporal abstractionsEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Discussion and conclusions: In this work we have considered the issue of visually composing and querying temporal clinical patient data. In this context we have proposed a visual framework for the specification of consistent temporal abstractions with different granularities and for the visual composition of different temporal abstractions to build (possibly) complex queries on clinical databases. A new algorithm has been proposed to check the consistency of the specified granular abstraction. From the evaluation of the proposed metaphors and interfaces and from the comparison of the visual query language with a well known...
Source: Artificial Intelligence in Medicine - January 21, 2012 Category: Bioinformatics Authors: Carlo Combi, Barbara Oliboni Tags: Research Articles Source Type: research
Use of electronic health record data to evaluate overuse of cervical cancer screening.Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
ConclusionSecondary analysis of EHR data can accurately measure the use of low-value services such as Pap testing performed sooner than recommended in women at low risk of cervical cancer. Similar application of our methodology could facilitate efforts to simultaneously improve quality and decrease costs, maximizing value in the US healthcare system.
PMID: 22268215 [PubMed - as supplied by publisher]
Source: Journal of the American Medical Informatics Association - January 19, 2012 Category: Information Technology Authors: Mathias JS, Gossett D, Baker DW Tags: J Am Med Inform Assoc Source Type: research
Targeted data extraction of the MS/MS spectra generated by data independent acquisition: a new concept for consistent and accurate proteome analysis.Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Abstract
Most proteomic studies use liquid chromatography coupled to tandem mass spectrometry to identify and quantify the peptides generated by the proteolysis of a biological sample. However with the current methods it remains challenging to rapidly, consistently, reproducibly, accurately, and sensitively detect and quantify large fractions of proteomes across multiple samples. Here we present a new strategy that systematically queries sample sets for the presence and quantity of essentially any protein of interest. It consists of using the information available in fragment ion spectral libraries to mine the comp...
Source: Molecular and Cellular Proteomics : MCP - January 18, 2012 Category: Molecular Biology Authors: Gillet LC, Navarro P, Tate S, Roest H, Selevsek N, Reiter L, Bonner R, Aebersold R Tags: Mol Cell Proteomics Source Type: research
MPs query 'carer spotting' schemeEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
MPs question a government-supported scheme which sees supermarkets helping to identify carers.
Source: BBC News | Health | UK Edition - January 17, 2012 Category: Consumer Health News Source Type: news
The influence of eating rate on satiety and intake among participants exhibiting high dietary restraint.Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
CONCLUSION: Eating slower is not likely to be an effective strategy to control intake in a meal among those exhibiting HDR.
PMID: 22232571 [PubMed - in process]
Source: Food and Nutrition Research - January 17, 2012 Category: Nutrition Authors: Privitera GJ, Cooper KC, Cosco AR Tags: Food Nutr Res Source Type: research
Use of cognitive question testing methodologies in participant action research: Implementing the three-step test-interview method in Indian county.Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
This study describes the use of cognitive question testing methods to pretest a Web-based questionnaire designed to gather information from American Indian and Alaska Native (AI/AN) youth between the ages of 18 and 25. The questionnaire included items related to risk and resiliency factors as well as potentially sensitive topics of victimization and delinquency. Question testing was completed with a sample of 15 youth living in three different regions of the United States. The Three Step Test Interview Method was modified to collect information related to interface usability, cognitive response, and cultural interpretation...
Source: Cultural Diversity and Ethnic Minority Psychology - January 16, 2012 Category: Psychiatry & Psychology Authors: Pavkov, Thomas W.;Priest, Jacob;Fox, Kathleen Source Type: research
Data-driven information retrieval in heterogeneous collections of transcriptomics data links SIM2s to malignant pleural mesotheliomaEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Motivation: Genome-wide measurement of transcript levels is an ubiquitous tool in biomedical research. As experimental data continues to be deposited in public databases, it is becoming important to develop search engines that enable the retrieval of relevant studies given a query study. While retrieval systems based on meta-data already exist, data-driven approaches that retrieve studies based on similarities in the expression data itself have a greater potential of uncovering novel biological insights.
Results: We propose an information retrieval method based on differential expression. Our method deals with arbitrary ex...
Source: Bioinformatics - January 16, 2012 Category: Bioinformatics Authors: Caldas, J., Gehlenborg, N., Kettunen, E., Faisal, A., Ronty, M., Nicholson, A. G., Knuutila, S., Brazma, A., Kaski, S. Tags: DATA AND TEXT MINING Source Type: research
Surgical Outcomes for Type-A Aortic Dissection in Septuagenarians and OctogenariansEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Conclusions: Data suggest that despite high morbidity and mortality, satisfactory long-term survival can be achieved for 70- and 80-year-old patients requiring surgical treatment for TAAD. However, interpretation of this study, and other similar ones, must account for a likely high degree of bias in selection of only the good-risk (elderly) patients for surgery. in elderly patients treated surgically for TAAD, EF predicts mortality in the younger portion of this (elderly) group. This trend diminishes as age increases.
Source: Journal of Surgical Research - January 14, 2012 Category: Surgery Authors: N. Dobrilovic, A.K. Singh, J.G. Fingleton, A. Maslow, J. Machan, J. Feng, F.W. Sellke Source Type: research
Google Flu Trends: Correlation With Emergency Department Influenza Rates and Crowding MetricsEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
This study assesses the temporal correlation of city GFT data to cases of influenza and standard crowding [...]
Source: ICMCC: The International Council on Medical and Care Compunetics - January 11, 2012 Category: Information Technology Authors: Lodewijk Tags: Bibliography Journal Article Science Disease Surveillance emergency Internet Source Type: news
An Interactive System for Computer-Aided Diagnosis of Breast MassesEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
This study demonstrated the feasibility of developing an interactive CAD system with a large reference database
and achieving improved performance.
Content Type Journal ArticlePages 1-10DOI 10.1007/s10278-012-9451-0Authors
Xingwei Wang, Department of Radiology, University of Pittsburgh, 3362 Fifth Avenue, Pittsburgh, PA 15213, USALihua Li, College of Life Information Science and Instrument Engineering, Hangzhou Dianzi University, Hangzhou, 310018 ChinaWei Liu, College of Life Information Science and Instrument Engineering, Hangzhou Dianzi University, Hangzhou, 310018 ChinaWeidong Xu, College of Life Information Sci...
Source: Journal of Digital Imaging - January 10, 2012 Category: Radiology Tags: Journal of Digital Imaging Source Type: research
Laparoscopic resection of gastric gastrointestinal stromal tumors presenting as left adrenal tumors.Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
We report two documented cases of gastric GISTs mimicking left adrenal tumors which were successfully treated with pure laparoscopic adrenalectomy and wedge resection of the stomach by excising the tumor from the stomach with serial firing of endoscopic gastrointestinal staplers. The surgical margins were clear, and the patients recovered smoothly. No adjuvant therapy with imatinib was prescribed. During the surveillance for 9 mo and 44 mo respectively, no tumor recurrence and metastasis were documented. Laparoscopic tumor excision, when adhering to the principles of surgical oncology, seems feasible and the prognosis is f...
Source: World Journal of Gastroenterology : WJG - January 7, 2012 Category: Gastroenterology Authors: Chung SD, Chueh JS, Yu HJ Tags: World J Gastroenterol Source Type: research
Inflammatory pseudotumor of the liver and spleen diagnosed by percutaneous needle biopsy.Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
In this study, a case of a woman aged over 70 years was reported, who presented with a general malaise lasting more than two months. A computed tomography scan demonstrated a diffusely spread lesion of the liver with a portal vein occlusion and a splenic lesion surrounded by a soft density layer. Since the percutaneous liver biopsy showed findings that suggested an IPT, although the radiological findings did not exclude the possibility of a malignancy, we performed a percutaneous spleen biopsy to enable a more definitive diagnosis. The microscopic findings from the spleen specimen lead us to a diagnosis of IPT involving th...
Source: World Journal of Gastroenterology : WJG - January 7, 2012 Category: Gastroenterology Authors: Kawaguchi T, Mochizuki K, Kizu T, Miyazaki M, Yakushijin T, Tsutsui S, Morii E, Takehara T Tags: World J Gastroenterol Source Type: research
Unsuccessful treatment of four patients with acute graft-vs-host disease after liver transplantation.Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
CONCLUSION: New and effective treatments are required for GVHD after liver transplantation to improve the prognosis of patients with this diagnosis.
PMID: 22228975 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - January 7, 2012 Category: Gastroenterology Authors: Chen XB, Yang J, Xu MQ, Wen TF, Yan LN Tags: World J Gastroenterol Source Type: research
Growth inhibitory effect of 4-phenyl butyric acid on human gastric cancer cells is associated with cell cycle arrest.Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
CONCLUSION: The growth inhibitory effect of PBA on gastric cancer cells is associated with alteration of the cell cycle. For moderately-differentiated gastric cancer cells, the cell cycle was arrested at the G(0)/G(1) and G(2)/M phases. For lowly-differentiated gastric cancer cells, the cell cycle was arrested at the G(0)/G(1) and S phases.
PMID: 22228974 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - January 7, 2012 Category: Gastroenterology Authors: Li LZ, Deng HX, Lou WZ, Sun XY, Song MW, Tao J, Xiao BX, Guo JM Tags: World J Gastroenterol Source Type: research
Germline promoter hypermethylation of tumor suppressor genes in gastric cancer.Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
CONCLUSION: Mosaic germline epimutation of the MLH1 gene is present in suspected hereditary GC patients in China but at a very low level. Germline epimutation of the CDH1 or P16(INK4a) gene is not a frequent event.
PMID: 22228973 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - January 7, 2012 Category: Gastroenterology Authors: Wu PY, Zhang Z, Wang JM, Guo WW, Xiao N, He Q, Wang YP, Fan YM Tags: World J Gastroenterol Source Type: research
Risk factors for adverse outcome in low rectal cancer.Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
CONCLUSION: Despite a higher rate of positive resection margins after APR, the type of surgery was not identified as an independent risk factor for survival.
PMID: 22228972 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - January 7, 2012 Category: Gastroenterology Authors: Chen ZH, Song XM, Chen SC, Li MZ, Li XX, Zhan WH, He YL Tags: World J Gastroenterol Source Type: research
Efficacy and safety of treatment of hepatitis C virus infection in renal transplant recipients.Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
CONCLUSION: The combination of pegylated interferon and ribavirin is effective in suppressing HCV-RNA, with a low risk of graft rejection or failure in HCV infected renal transplant recipients.
PMID: 22228971 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - January 7, 2012 Category: Gastroenterology Authors: Aljumah AA, Saeed MA, Al Flaiw AI, Al Traif IH, Al Alwan AM, Al Qurashi SH, Al Ghamdi GA, Al Hejaili FF, Al Balwi MA, Al Sayyari AA Tags: World J Gastroenterol Source Type: research
Outcome after gastrectomy in gastric cancer patients with type 2 diabetes.Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
CONCLUSION: The course of T2DM was significantly correlated to the BMI reduction ratio but not to the type of surgery without a significant change in BMI.
PMID: 22228970 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - January 7, 2012 Category: Gastroenterology Authors: Kim JW, Cheong JH, Hyung WJ, Choi SH, Noh SH Tags: World J Gastroenterol Source Type: research
Influence of proton pump inhibitor treatment on Helicobacter pylori stool antigen test.Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
CONCLUSION: The stool antigen test was equally sensitive to the UBT, making it a useful and reliable diagnostic method, even during PPI administration.
PMID: 22228969 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - January 7, 2012 Category: Gastroenterology Authors: Kodama M, Murakami K, Okimoto T, Fukuda Y, Shimoyama T, Okuda M, Kato C, Kobayashi I, Fujioka T Tags: World J Gastroenterol Source Type: research
Increased numbers of Foxp3-positive regulatory T cells in gastritis, peptic ulcer and gastric adenocarcinoma.Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
CONCLUSION: Tregs are positively associated with endoscopic findings of gastroduodenal diseases and histological grade but negatively associated with intestinal metaplasia in gastritis and peptic ulcer groups.
PMID: 22228968 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - January 7, 2012 Category: Gastroenterology Authors: Cheng HH, Tseng GY, Yang HB, Wang HJ, Lin HJ, Wang WC Tags: World J Gastroenterol Source Type: research
An update on chemotherapy of colorectal liver metastases.Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Abstract
Surgical resection of liver metastases of colorectal cancer greatly improves the clinical outcome of patients with advanced disease. Developments in chemotherapeutic agents and strategies bring hope of a cure to patients with initially unresectable colorectal liver metastases (CLM). Perioperative chemotherapy significantly improves the survival time of patients who receive curative-intent hepatectomy. Even for unresectable CLM, recent studies demonstrated that active preoperative chemotherapy could achieve shrinkage of liver metastasis and thus render some for resection. Furthermore, an increase in tumor r...
Source: World Journal of Gastroenterology : WJG - January 7, 2012 Category: Gastroenterology Authors: Wang CC, Li J Tags: World J Gastroenterol Source Type: research
Multi-modality treatment of colorectal liver metastases.Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Abstract
Liver metastases synchronously or metachronously occur in approximately 50% of colorectal cancer patients. Multimodality comprehensive treatment is the best therapeutic strategy for these patients. However, the optimal pattern of multimodality therapy is still controversial, and it raises several significant concerns. Liver resection is the most important treatment for colorectal liver metastases. The definition of resectability has shifted to focus on the completion of R0 resection and normal liver function maintenance. The role of neoadjuvant and adjuvant chemotherapy still needs to be clarified. The man...
Source: World Journal of Gastroenterology : WJG - January 7, 2012 Category: Gastroenterology Authors: Cai GX, Cai SJ Tags: World J Gastroenterol Source Type: research
Recurrence and rejection in liver transplantation for primary sclerosing cholangitis.Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Abstract
Primary sclerosing cholangitis (PSC) is a chronic progressive inflammatory disease affecting the bile ducts, leading to fibrosis and eventually cirrhosis in most patients. Its etiology is unknown and so far no effective medical therapy is available. Liver transplantation (LTX) is the only curative treatment and at present PSC is the main indication for LTX in the Scandinavian countries. Close to half of the PSC patients experience one or more episodes of acute cellular rejection (ACR) following transplantation and approximately 1/5 of the transplanted patients develop recurrent disease in the graft. In add...
Source: World Journal of Gastroenterology : WJG - January 7, 2012 Category: Gastroenterology Authors: Fosby B, Karlsen TH, Melum E Tags: World J Gastroenterol Source Type: research
Querying Genomic Databases: Refining the Connectivity MapEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
The advent of high-throughput biotechnologies, which can efficiently measure gene expression on a global basis, has led to the creation and population of correspondingly rich databases and compendia. Such repositories have the potential to add enormous scientific value beyond that provided by individual studies which, due largely to cost considerations, are typified by small sample sizes. Accordingly, substantial effort has been invested in devising analysis schemes for utilizing gene-expression repositories. Here, we focus on one such scheme, the Connectivity Map (cmap), that was developed with the express purpose of iden...
Source: Statistical Applications in Genetics and Molecular Biology - January 6, 2012 Category: Genetics & Stem Cells Tags: Computational Biology/Bioinformatics Microarrays Statistical Theory and Methods Source Type: research
Mystery bird: Swallow-tailed cotinga, Phibalura flavirostris | @GrrlScientistEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
This monotypic species is a taxonomic orphan: no one knows which family it belongs to (includes video) Swallow-tailed cotinga, Phibalura flavirostris flavirostris, Vieillot, 1816, photographed at Intervales State Park, São Paulo state, Brazil (South America). Image: Nick Athanas/Tropical Birding, 1 October 2007 (with permission) [velociraptorize].Samsung digital camera I encourage you to purchase images from the photographers who freely share their beautiful work with us. Question: This Brazilian mystery bird species is poorly known and is placed in a taxonomic family that I've never shown to you before. Can you identify ...
Source: Guardian Unlimited Science - January 6, 2012 Category: Science Authors: GrrlScientist Tags: Science guardian.co.uk Blogposts Source Type: news
Mystery bird: Swallow-tailed cotinga, Phibalura flavirostris | GrrlScientistEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
This monotypic species is a taxonomic orphan: no one knows which family it belongs to (includes video)Swallow-tailed cotinga, Phibalura flavirostris flavirostris, Vieillot, 1816, photographed at Intervales State Park, São Paulo state, Brazil (South America). Image: Nick Athanas/Tropical Birding, 1 October 2007 (with permission) [velociraptorize].Samsung digital camera I encourage you to purchase images from the photographers who freely share their beautiful work with us. Question: This Brazilian mystery bird species is poorly known and is placed in a taxonomic family that I've never shown to you before. Can you identify t...
Source: Guardian Unlimited Science - January 6, 2012 Category: Science Authors: GrrlScientist Tags: Zoology Science Birds Wildlife Animals guardian.co.uk Blogposts Source Type: news
Full-time orthopedic traumatologists enhance rural trauma center pelvic fracture outcomes and financials. - Testerman GM, Harris RM, West M, Easparam S.Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
We hypothesized that full-time orthopedic traumatologists would increase interfacility transfer patients with pelvic ring injuries at a trauma center seeking American College of Surgeons Level I verification. A trauma registry query identified 790 patients...
Source: SafetyLit: All (Unduplicated) - January 6, 2012 Category: Global & Universal Tags: Non-Categorized Source Type: news
Physician Data Query (PDQ(R)) UpdateEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Source: JNCI - January 3, 2012 Category: Cancer & Oncology Tags: NEWS Source Type: research
SciFinder - Latest EnhancementsEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
The latest SciFinder enhancements help scientists quickly find the substance information most relevant to their research. New bioactivity and target indicator features let scientists easily assess the biological relevance of a specific substance or an entire substance answer set. With new substance relevance ranking, scientists can quickly review answer sets and access the substances that are most similar to their query.
Source: CAS - Chemical Abstracts Service - January 1, 2012 Category: Chemistry Source Type: news
Diuretic use, increased serum urate levels, and risk of incident gout in a population‐based study of adults with hypertension: The Atherosclerosis Risk in Communities cohort studyEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
ConclusionThiazide and loop diuretics were associated with increased gout risk, an association mediated by a change in serum urate levels.
Source: Arthritis and Rheumatism - January 1, 2012 Category: Rheumatology Authors: Mara A. McAdams DeMarcoJanet W. MaynardAlan N. BaerAllan C. GelberJ. Hunter YoungAlvaro AlonsoJosef Coresh Tags: Gout Source Type: research
Empirical versus pre-emptive antifungal therapy for persistent febrile neutropenia.Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
PMID: 22210330 [PubMed - in process]
Source: Haematologica - January 1, 2012 Category: Hematology Authors: Castagnola E, Haupt R Tags: Haematologica Source Type: research
Patient and physician characteristics associated with erythropoiesis-stimulating agent use in patients with myelodysplastic syndromes.Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Abstract
Patient and physician characteristics associated with use of erythropoiesis-stimulating agents in myelodysplastic syndrome patients have not yet been described. Myelodysplastic syndrome patients diagnosed from 2001 to 2005 were identified from the Surveillance Epidemiology and End Results-Medicare database. Multivariate regressions examined the association between patient and physician characteristics and the probability of receiving any erythropoiesis-stimulating agents, and of receiving therapeutic-length (≥8 week) treatment episodes. Among the 6,588 myelodysplastic syndrome patients studied, 65% recei...
Source: Haematologica - January 1, 2012 Category: Hematology Authors: Davidoff AJ, Weiss Smith S, Baer MR, Ke X, Bierenbaum JM, Hendrick F, McNally DL, Gore SD Tags: Haematologica Source Type: research
ATM and chronic lymphocytic leukemia: mutations, and not only deletions, matter.Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
PMID: 22210328 [PubMed - in process]
Source: Haematologica - January 1, 2012 Category: Hematology Authors: Rossi D, Gaidano G Tags: Haematologica Source Type: research
The corepressors BCOR and BCORL1: two novel players in acute myeloid leukemia.Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
PMID: 22210327 [PubMed - in process]
Source: Haematologica - January 1, 2012 Category: Hematology Authors: Tiacci E, Grossmann V, Martelli MP, Kohlmann A, Haferlach T, Falini B Tags: Haematologica Source Type: research
The other Achilles' heel of BCR-ABL1.Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
PMID: 22210326 [PubMed - in process]
Source: Haematologica - January 1, 2012 Category: Hematology Authors: De Keersmaecker K Tags: Haematologica Source Type: research
