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Fight Aging! Newsletter, December 24th 2018
In conclusion, we found a gradient of increasing blood pressure with higher levels of BMI. The fact that this gradient is present even in the fully adjusted analyses suggests that BMI may cause a direct effect on blood pressure, independent of other clinical risk factors.
PRRX1 as a Possible Point of Control for Remyelination
https://www.fightaging.org/archives/2018/12/prrx1-as-a-possible-point-of-control-for-remyelination/
Researchers here outline what is possibly a new point of intervention in the processes that maintain the myelin sheath that wraps nerves. This sheath is vital to the correct operatio...
Source: Fight Aging! - December 23, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Johnson and Johnson ' s Latest Ethical Misadventures: Settled Kickback Allegations, Reportedly Concealed Knowledge of Adverse Effects of a " Sacred Cow " Product
Giant pharmaceutical/ biotechnology/ device company Johnson& Johnson has its famous" credo " which starts withWe believe our first responsibility is to the doctors, nurses and patients, to mothers and fathers and all others who use our products and services. In meeting their needs everything we do must be of high quality..Nonetheless, the company has a long history of ethical misadventures (lookhere, and see appendix below). Now late in 2018, we note two more Johnson& Johnson misadventures. In chronological order,$360 Million Settlement of Allegations of Kickbacks to Medicare/ Medicaid Patients to...
Source: Health Care Renewal - December 15, 2018 Category: Health Management Tags: adulterated drugs adverse effects deception impunity Johnson and Johnson kickbacks legal settlements Source Type: blogs
Fight Aging! Newsletter, November 5th 2018
In conclusion, weight cycling significantly increased life-span relative to remaining with obesity and had a similar benefit to sustained modest weight loss.
Support for Oxidized Cholesterol as a Primary Cause of Atherosclerosis
https://www.fightaging.org/archives/2018/11/support-for-oxidized-cholesterol-as-a-primary-cause-of-atherosclerosis/
In the paper I'll point out today, the authors provide evidence in support of the concept that it is specifically oxidized cholesterol that is the primary cause of atherosclerosis rather than the condition resulting from too much cholesterol in general. In atheroscl...
Source: Fight Aging! - November 4, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Recent Research into the Interaction of Exercise and Aging
Today's open access papers touch on aspects of the interaction between exercise and the pace of aging. People age at somewhat different rates, and for the vast majority of us lifestyle is a far greater determinant of that rate than our genes. Until such time as the clinical deployment of rejuvenation therapies is well underway, and in regions of the world sufficiently wealthy to have tamed the majority of infectious disease, it remains the case that our choices regarding our health, such as calorie restriction and exercise, are the most reliable means of improving life expectancy. The size of the effect is not enormous in ...
Source: Fight Aging! - November 2, 2018 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
To help restore healthy bowel flora, eat no GMOs
One of the most potentially harmful aspects of genetically-modified crops, or GMOs, are that such crops are often engineered to be resistant to specific herbicides or pesticides. A farmer therefore can spray an herbicide to kill weeds, while the GM crop plant survives. But it means that the plant now has herbicide residues in it. Or it may contain its own built-in pesticide such as Bt toxin, expressed by the plant because the gene for this pest-resistant compound has been spliced into the plant’s genetic code. So GMO crops pose a double-whammy: the crop itself with new genetically-programmed components, especially pr...
Source: Wheat Belly Blog - October 29, 2018 Category: Cardiology Authors: Dr. Davis Tags: News & Updates dysbiosis Inflammation prebiotic probiotic sibo small intestinal bacterial overgrowth wheat belly Source Type: blogs
Fight Aging! Newsletter, October 15th 2018
This study suggests that exocrine glands can be induced from pluripotent stem cells for organ replacement regenerative therapy.
Replacement of Aged Microglia Partially Reverses Cognitive Decline in Mice
https://www.fightaging.org/archives/2018/10/replacement-of-aged-microglia-partially-reverses-cognitive-decline-in-mice/
Researchers here report on a compelling demonstration that shows the degree to which dysfunctional microglia contribute to age-related neurodegeneration. The scientists use a pharmacological approach to greatly deplete the microglial population and then allow it to recover naturally. The...
Source: Fight Aging! - October 14, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Few More Reasons Not to Become Overweight and Obese
Being obese or overweight is, for the overwhelming majority of such individuals, a choice. There is plenty of ink spilled over how hard or easy the choice of body weight is to make, but it is nonetheless a choice. Want to weigh less? Then persist in eating fewer calories in the context of a sanely balanced diet. It really is as simple as that. The only way to fail is to fail to eat fewer calories. That this is eternally a challenge, and that obesity is increasingly prevalent in an environment of cheap calories, tells us more about human nature than it does about our biology.
The present consensus on the effects of e...
Source: Fight Aging! - October 11, 2018 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Why Do We Forgive?
This study, the first to elucidate the cumulative effects of severe stress and forgiveness on mental health, led authors to suggest development of a more forgiving coping strategy may be beneficial in reducing stress-caused disorders and conditions.
We Choose to Forgive
Considered a forgiveness trailblazer by Time Magazine and other media, Robert D. Enright, professor of psychology at the University of Wisconsin, Madison and president of the International Forgiveness Institute at UWMadison, is the author of Forgiveness Is a Choice: A Step-by-Step Process for Resolving Anger and Restoring Hope. In this self-help book, Enrig...
Source: World of Psychology - October 6, 2018 Category: Psychiatry & Psychology Authors: Suzanne Kane Tags: Ethics & Morality Family Friends Inspiration & Hope Source Type: blogs
Quite Simply: UNACCEPTABLE
Last week, my mom stunned me with bad news: A young woman named Tiffany Costa died. She was diagnosed with breast cancer in 2002 and died two weeks ago from stage II breast cancer at just 29 years old. She was metastatic for many years.
Tiffany’s extended family members are dear friends of my mom. I came to “meet” Tiffany because of an email my mom forwarded to me. She was being treated with Doxil. There was (and it would appear there still IS) a shortage of Doxil and she was trying to raise money to have the drugs brought into this country from Europe. The cost was exorbitant. I remember reading the email and I reca...
Source: Disruptive Women in Health Care - September 25, 2018 Category: Consumer Health News Authors: dw at disruptivewomen.net Tags: Uncategorized Source Type: blogs
FDA Launches New Campaign to Warn Kids about the Dangers of E-Cigarettes
The FDA launched a new, comprehensive campaign to warn kids about the dangers of e-cigarette use as part of the agency’s Youth Tobacco Prevention Plan.
“The Real Cost” Youth E-Cigarette Prevention Campaign will target nearly 10.7 million at-risk youth through digital platforms, social media, and in-school ads nationwide. With its tagline, “Know the Real Cost of Vaping,” the campaign aims to educate youth that using e-cigarettes, just like cigarettes, puts them at risk for addiction and other health consequences. The messages highlight that nicotine can rewire the brain to crave more nicotine, particularly because...
Source: BHIC - September 19, 2018 Category: Databases & Libraries Authors: Michelle Burda Tags: Children and Teens General Source Type: blogs
Writing as an antidote to loneliness
It may not seem possible to be able to write your way to better health. But as a doctor, a public health practitioner, and a poet myself, I know what the scientific data have to say about this: when people write about what’s in their hearts and minds, they feel better and get healthier. And it isn’t just that they’re getting their troubles off their chests.
Writing provides a rewarding means of exploring and expressing feelings. It allows you to make sense of yourself and the world you are experiencing. Having a deeper understanding of how you think and feel — that self-knowledge — provides you with a stronger co...
Source: Harvard Health Blog - September 14, 2018 Category: Consumer Health News Authors: Jeremy Nobel, MD, MPH Tags: Behavioral Health Mental Health Stress Source Type: blogs
Fight Aging! Newsletter, September 10th 2018
In conclusion, HSC ageing is characterised by reduced self-renewal, myeloid and platelet HSC skewing, and expanded clonal haematopoiesis that is considered a preleukaemic state. The underlying molecular mechanisms seem to be related to increased oxidative stress due to ROS accumulation and DNA damage, which are influenced by both cell- and cell non-autonomous mechanisms such as prolonged exposure to infections, inflammageing, immunosenescence, and age-related changes in the HSC niche. Thus, HSC ageing seems to be multifactorial and we are only beginning to connect all the dots.
The Price of Progress or the Waste...
Source: Fight Aging! - September 9, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
MRI Uncovers Missing Contact Lens Found 28 Years Later in Patient ’s Upper Eyelid
In Scotland, a contact lens that had gone missing for nearlythree decades was finally located when the owner of the lens underwent a MRI for upper eyelid swelling and ptosis.The MRI had indicated a cyst with proteinaceous content. When surgeons made an excision of the cyst, a rigid gas permeable (RGO) lens was discovered, deep in the upper eyelid soft tissue.“The features on the MRI were in keeping with a cyst with proteinaceous content. There were no radiological features of a foreign body seen within the cyst,” wrotethe patient ’s ophthalmologists in a report published in BMJ Case Reports.The disappearance of the...
Source: radRounds - August 30, 2018 Category: Radiology Authors: Julie Morse Source Type: blogs
Have You Run Out of Spoons? It ’ s Time to Replenish Your Energy Reserves
A few days ago, a friend indicated on her Facebook page that she had “run out of spoons” and asked for support and energy to be sent her way. I had heard the term but didn’t know what it meant, so I turned to Google and typed in those words and what came up was the explanation that came from a conversation between two friends, one of whom had Lupus.
Christine Miserandino was sitting at a table with her college roommate who asked her what it was like to have a disease that for many people would be considered invisible since overt symptoms may be elusive to the casual observer.
Christine pondered for an ever ...
Source: World of Psychology - August 15, 2018 Category: Psychiatry & Psychology Authors: Edie Weinstein, MSW, LSW Tags: Caregivers Inspiration & Hope Motivation and Inspiration Policy and Advocacy Stigma alone time caregiving Disability Disability Advocacy energy Rejuvenation Source Type: blogs
Fight Aging! Newsletter, August 13th 2018
We report that the disruption of excitation-contraction coupling contributes to impaired force generation in the mouse model of Sod1 deficiency. Briefly, we found a significant reduction in sarcoplasmic reticulum Ca2+ ATPase (SERCA) activity as well as reduced expression of proteins involved in calcium release and force generation. Another potential factor involved in EC uncoupling in Sod1-/- mice is oxidative damage to proteins involved in the contractile response.
In summary, this study provides strong support for the coupling between increased oxidative stress and disruption of cellular excitation contraction mac...
Source: Fight Aging! - August 12, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
