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Fight Aging! Newsletter, January 29th 2018
In conclusion, the present study demonstrated that TIGIT is a prominent negative immune regulator involved in immunosenescence. This novel finding is highly significant, as targeting TIGIT might be an effective strategy to improve the immune response and decrease age-related comorbidities. Delivery of Extracellular Vesicles as a Potential Basis for Therapies https://www.fightaging.org/archives/2018/01/delivery-of-extracellular-vesicles-as-a-potential-basis-for-therapies/ Here I'll point out a readable open access review paper on the potential use of extracellular vesicles as a basis for therapy: harveste...
Source: Fight Aging! - January 28, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, January 22nd 2018
In conclusion, death is a natural part of human existence, but human progress is essentially a story of overcoming undesirable natural limits. In the near future, technological progress might make it possible to stop natural biological death. Should humankind embrace such technology? Yes: Even though such technology would not be without risks, the risks are almost certainly manageable. The benefits of ending natural death, on the other hand, are immense. Death is an obstacle that is slowing down human progress. If we remove that obstacle, humankind could increase the speed of both its moral and its epistemic progress. ...
Source: Fight Aging! - January 21, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, November 27th 2017
We examined associations between mortality and accelerometer-measured PA using age-relevant intensity cutpoints in older women of various ethnicities. The results support the hypothesis that higher levels of accelerometer-measured PA, even when below the moderate-intensity threshold recommended in current guidelines, are associated with lower all-cause and CVD mortality in women aged 63 to 99. Our findings expand on previous studies showing that higher self-reported PA reduces mortality in adults aged 60 and older, specifically in older women, and at less than recommended amounts. Moreover, our findings challenge th...
Source: Fight Aging! - November 26, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

James Peyer at TEDxStuttgart: Can We Defeat the Diseases of Aging?
My attention was drawn today to a recently published presentation by James Peyer. He heads up Apollo Ventures, one of the new crop of investment concerns focused on funding companies that are developing means to treat aging. These include the Longevity Fund, first out of the gate some years ago, as well as Juvenescence and the Methuselah Fund, created this year, and a repurposing of existing funds, such as Michael Greve's Kizoo ventures. Apollo Ventures is the source of the Geroscience online magazine that helps to advance and explain the position taken on aging by this group; this is something that more investors should d...
Source: Fight Aging! - November 23, 2017 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs

Obstruction of Magendie's Foramen :MRI
 Case Report : A 33-year-old woman presented with visual disturbance and balance difficulty on MRI brain shows dilatation of lateral, III and IV ventricles along with periventricular T2/FLAIR hyperintensity. Temporal horns are dilated. Fourth ventricle appears dilated out of propotion along with prominent CSF flow void in the IV ventricle and some enhancement in ependymal surface of IV ventricle. Contour abnormality in the foramen of magendie. These findings are indicative of IV ventricular outflow tract obstruction possibly post infective sequele/arachnoiditis in foramen of magendieTeaching Points:Memb...
Source: Sumer's Radiology Site - September 7, 2017 Category: Radiology Authors: Sumer Sethi Source Type: blogs

Vaccine Ingredients: America ’s Dirty Little Secret
Conclusion The increase in childhood illness must have a cause or trigger. There must be common factors when half of America’s children are chronically ill. Could vaccine ingredients be the causal factor of the increase in childhood illnesses? This question remains unanswered by the CDC. As stated above, many CDC employees have a vested financial interest in continuing to sell and market vaccines. As childhood illnesses continue to increase, logic and reason must be applied to the debate and we must identify common factors. What do American children have in common? The large majority receive vaccines per the CDC schedule...
Source: vactruth.com - June 25, 2017 Category: Allergy & Immunology Authors: Sarah Carrasco Tags: Logical Sarah Carrasco Top Stories Polysorbate 80 truth about vaccines vaccine ingredients Source Type: blogs

Fight Aging! Newsletter, June 19th 2017
This study is the first to show that downregulation of PAPP-A expression in adult mice can significantly extend life span. Importantly, this beneficial longevity phenotype is distinct from the dwarfism of long-lived PAPP-A KO, Ames dwarf, Snell dwarf and growth hormone receptor (GHR) KO mice with germ-line mutations. Thus, downregulation of PAPP-A expression joins other treatment regimens, such as resveratrol, rapamycin and dietary restriction, which can extend life span when started in mice as adults. In a recent study, inducible knockdown of the GHR in young adult female mice increased maximal, but not median, lif...
Source: Fight Aging! - June 18, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, April 3rd 2017
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - April 2, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, March 27th 2017
In conclusion, DNAm of multiple disease-related genes are strongly linked to mortality outcomes. The recently established epigenetic clock (DNAm age) has received growing attention as an increasing number of studies have uncovered it to be a proxy of biological ageing and thus potentially providing a measure for assessing health and mortality. Intriguingly, we targeted mortality-related DNAm changes and did not find any overlap with previously established CpGs that are used to determine the DNAm age. Our findings are in line with evidence, suggesting that DNAm involved in ageing or health-related outcomes are mostly...
Source: Fight Aging! - March 26, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Why do patients accept chemotherapy, but not flu shots?
Fall brings school buses, a freshening breeze and an avalanche of meetings.  There are seasonal sales, myriad projects and the splendor of colored leaves.  The season is also announced, again and again, by a particular peculiar and perilous decision, which, no matter how much I try, I do not fully understand. Frankly, I just don’t get it. “Jane, it is time to start chemotherapy.” “What are the side effects?” “Well, this is powerful chemotherapy.  It is necessary to cure your cancer.  It will cause hair loss. It will cause a drop in your blood counts.  It might cause severe diarrhea.  There might be numbne...
Source: Kevin, M.D. - Medical Weblog - November 1, 2016 Category: Journals (General) Authors: < a href="http://www.kevinmd.com/blog/post-author/james-c-salwitz" rel="tag" > James C. Salwitz, MD < /a > Tags: Physician Medications Source Type: blogs

Meningitis FAQ
You know when they say the symptoms of meningitis are commonly a headache and a stiff neck and perhaps purple blotches on the skin that don’t pale when pressed…well…it can be far worse than that and can kill. If you’re in a vulnerable group, make sure you’re vaccinated. It is highly recommended that new university and college students are vaccinated because meningitis is far worse than a spot of “fresher’s flu” (usually just a cold) and can be passed on through coughs and sneezes, close contact and kissing infected people and even just sharing kitchen utensils. If it doesn...
Source: David Bradley Sciencebase - Songs, Snaps, Science - October 6, 2016 Category: Science Authors: David Bradley Tags: Science Source Type: blogs

The Dangerous Expansion of Adult Vaccinations
Conclusion The vaccination comprises a misguided and unsafe national health care program which claims to prevent disease. Many significant health injuries are associated with vaccinating adults. Government resources are being spent researching and developing new and different vaccinations. Subjecting adults to more vaccinations is likely to cause more health injury and illness. References: http://www.vaccinationcouncil.org/2012/07/05/herd-immunity… http://www.cdc.gov/chronicdisease/overview/ http://www.vaccinationcouncil.org/2011/02/18/60-lab-studies… http://www.cdc.gov/vaccines/schedules/hcp/adult.html http:...
Source: vactruth.com - September 10, 2016 Category: Allergy & Immunology Authors: Michelle Goldstein Tags: Logical Michelle Goldstein Recent Articles Top Stories adult vaccination adult vaccines new vaccines shingles vaccine truth about vaccines Source Type: blogs

So What Does RA Feel Like?
There is a big difference between rheumatoid arthritis and osteoarthritis. Osteoarthritis is the kind from overuse that causes your knee/elbow/hand to hurt when you over use it, or maybe even when you aren ' t using it. Rheumatoid arthritis is systemic and starts with your little joints - like your feet and hands. The joints become achy and bulge and more.Thisarticle explains better than anything else I have seen on what RA really feels like:Like the fatigue and exhaustion after climbing a mountain or running a marathon.Like the aches and pains after a significant fall or being in a car accident.Like the full body aches an...
Source: Caroline's Breast Cancer Blog - September 9, 2016 Category: Cancer & Oncology Tags: pain rheumatoid arthritis stress Source Type: blogs

Letting Go of a Depression Cure Can Set You Free
I keep going back to this quote by Vivian Greene when it comes to learning how to live with my chronic illness: “Life isn’t about waiting for the storm to pass… It’s about learning to dance in the rain.” In fact, every morning I drink out of a mug with that quote on it to remind myself of Vivian’s wisdom: IT’S NOT ABOUT GETTING TO THE OTHER SIDE. With chronic illness, the important exercise is to get out the rain boots and start stomping in the puddles — to not let the downpour stop you from living. Going into the second decade of living with a host of conditions — retractable depression, inflam...
Source: World of Psychology - September 7, 2016 Category: Psychiatry & Psychology Authors: Therese J. Borchard Tags: Depression Inspiration & Hope Mental Health and Wellness Motivation and Inspiration Personal Self-Help Bipolar Disorder Mood Disorder Stigma Source Type: blogs

How naive T cells decline with age
AIM, within the Institute for Basic Science (IBS), released an intriguing paper in Scientific Reports, on August 2, describing a novel explanation to a issue known to immunologists for decades: What causes the particular decline in immunity in outdated individuals? As soon as we are born we are destined to age, it’s a natural law which everyone adheres in order to. As we grow older our immunity gradually diminishes to a point where it is no longer able to effectively orchestrate an immune system response to fight and extinguish pathogens. The flu vaccine, for example , is only 17 to 53 percent effective in people age...
Source: My Irritable Bowel Syndrome Story - August 2, 2016 Category: Gastroenterology Authors: Ken Tags: IBS News Source Type: blogs