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Total 33 results found since Jan 2013.

Enabling partnerships for Alzheimer & #039;s disease drug development —meeting report
It was the best of times, it was the worst of times... --Charles Dickens. These words sum up the state of Alzheimer & rsquo;s disease (AD) research, specifically therapy development, over the last few years. On the one hand, the budget climate and dismal therapeutic results cloud the future. On the other hand, there are tremendous opportunities presented by the U.S. National Plan to Address Alzheimer & rsquo;s Disease and by the emergence of systems and precision medicine. These could transform AD research and drug development.
Source: Inside NIA: A Blog for Researchers - June 12, 2013 Category: Geriatrics Authors: Suzana Petanceska, Program Director, Division of Neuroscience Source Type: blogs

Clinical Trial for Alzheimer ' s Disease - Is LMTX Ineffective or Unprecedented?
Conclusions : The outcomes of this phase 3 trial will highlight the potential therapeutic value of tau aggregation inhibitor therapy in AD. A second phase 3 trial of LMTM for AD will be completed and reported later in 2016.
Source: The Neurocritic - July 28, 2016 Category: Neuroscience Authors: The Neurocritic Source Type: blogs

Link feast
Our editor’s pick of the 10 best psychology and neuroscience links from the last week or so:  Why We should Celebrate Shyness From Agatha Christie and Charles Darwin to Keira Knightley, Francoise Hardy and Morrissey, the socially awkward and anxious have changed the world for the better. Have we forgotten the benefits of being shy? How to Talk to Strangers The health benefits are clear. The political benefits are newly relevant Worldwide initiatives to advance brain research To highlight worldwide efforts to fund neuroscience research and address the growing threat of brain disorders, Nature Neuroscience asked lea...
Source: BPS RESEARCH DIGEST - September 3, 2016 Category: Psychiatry & Psychology Authors: researchdigestblog Tags: Feast Source Type: blogs

Sleep Deprivation May Contribute to Alzheimer ’s
A study published in JAMA Neurology reports that participants with evidence of preclinical Alzheimer's experienced worse sleep efficiency than those with no evidence of potential Alzheimer’s. One hundred forty five people between ages 45 and 75 took part in the study conducted by researchers at the Charles F. and Joanne Knight Alzheimer's Disease Research Center, Washington University School of Medicine. While none of the study participants had any cognitive concerns, once their spinal fluid was analyzed test results showed that about one-third of them were very likely to have Alzheimer's-linked Amyloid plaqu...
Source: Minding Our Elders - September 11, 2016 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs

Nature vs Nurture
  By, SAURABH JHA MD My wife chooses sides in the nature-versus-nurture war expeditiously. When our children are polite, she credits her nurture. When they’re rowdy, she blames my genes. But the nature-nurture war won’t be resolved anytime soon. The gene played a significant role in the great Indian epic, the Mahabharata. Karna, abandoned by his mother, Kunti, and raised by a charioteer, was taught warfare by Parashurama, a gifted teacher with a fiery temperament, who despised warriors and only taught Brahmins. One day, Parashurama was asleep with his head on Karna’s lap. Karna was bitten by a scorpion but d...
Source: The Health Care Blog - April 29, 2017 Category: Consumer Health News Authors: John Irvine Tags: Uncategorized Source Type: blogs

Alzheimer's Care When a Loved One with Alzheimer's Doesn't Recognize You (Part 1)
Our reader Pat, an Alzheimer's caregiver, is dealing with a problem that is more common than I would like to admit.Not being recognized by a loved one is both gut wrenching and heartbreaking. I know because I have talked about this in person with hundreds of caregivers.Pat wrote,"When my husband doesn't recognize me, he keeps asking where is Pat his wife. If I tell him I'm his wife Pat it irritates him and he says no I'm not his wife. I can't seem to satisfy him no matter what I say. Hope u have a good answer for me. He keeps asking where is his wife?"I asked our top expertDr. Rita Jablonski to respond to Pat's questi...
Source: Alzheimer's Reading Room, The - November 30, 2017 Category: Neurology Tags: alzheimer's not recognizing spouse alzheimers care care of dementia patients dementia care my mom doesn't recognize me Source Type: blogs

Lack of sleep can lead to Alzheimer ’s and dementia
This study is the clearest demonstration in humans that sleep disruption leads to an increased risk of Alzheimer’s disease through an amyloid beta mechanism,” said senior author Randall Bateman, MD, the Charles F. and Joanne Knight Distinguished Professor of Neurology. “The study showed that it was due to overproduction of amyloid beta during sleep deprivation.”More than 5 million Americans are living with Alzheimer ’s, a disease characterized by gradual memory loss and cognitive decline.What is the Difference Between Alzheimer ’s and DementiaThis study indicatesthat sleeping poorly increases levels of bra...
Source: Alzheimer's Reading Room, The - December 28, 2017 Category: Neurology Tags: health lack of sleep alzheimer's lack of sleep dementia poor sleep linked to alzheimer Source Type: blogs

New $30M venture philanthropy fund aims at revolutionizing the diagnosis of Alzheimer ’s Disease
_____ Why diagnosing Alzheimer’s today is so difficult—and how we can do better (Bill Gates): “Alzheimer’s research is a frontier where we can dramatically improve human life—both the lives of people who have the disease and their loved ones. I’m optimistic that we can substantially alter the course of Alzheimer’s if we make progress in several key areas. One of the biggest things we could do right now is develop a reliable, affordable, and accessible diagnostic. The process of getting diagnosed with Alzheimer’s today is less than ideal…First, it can be expensive and invasive…Second, patients aren’t b...
Source: SharpBrains - August 8, 2018 Category: Neuroscience Authors: SharpBrains Tags: Cognitive Neuroscience Health & Wellness ADDF Alzheimer’s Drug Discovery Foundation Alzheimers-research Bill Gates Brain-health cognitive-decline diagnosis diagnostics Diagnostics Accelerator venture philanthropy Source Type: blogs

Fight Aging! Newsletter, May 20th 2019
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - May 19, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Journalists Have Very Fragmentary, Incomplete Views of the Longevity Industry
The lengthy and somewhat overwrought article I'll point out today is a good example of the way in which journalists fail when writing on the topic of the growing biotechnology industry that is making the first steps towards the medical control of aging. They talk to just a few people, and thus have a very narrow (generously) or absolutely incorrect (more accurately) view of what might be happening, the prospects for the future, and the shape of the field as a whole. In this case the few people are the folk at AgeLab at MIT, and George Church, with a focus on the veterinary deployment of gene therapies by Rejuvenate Bio, an...
Source: Fight Aging! - May 21, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Fight Aging! Newsletter, May 27th 2019
In this study, we found that cofilin competes with tau for direct microtubule binding in vitro, in cells, and in vivo, which inhibits tau-induced microtubule assembly. Genetic reduction of cofilin mitigates tauopathy and synaptic defects in Tau-P301S mice and movement deficits in tau transgenic C. elegans. The pathogenic effects of cofilin are selectively mediated by activated cofilin, as active but not inactive cofilin selectively interacts with tubulin, destabilizes microtubules, and promotes tauopathy. These results therefore indicate that activated cofilin plays an essential intermediary role in neurotoxic signaling th...
Source: Fight Aging! - May 26, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Inside Schizophrenia: The Role Nurses Play in Schizophrenia Treatment
Some of the professionals that work most with helping people with schizophrenia are nurses. There are so many types with different skill sets. Host Rachel Star Withers and Co-host Gabe Howards learn who these often overlooked healthcare workers are. Dr. Tari Dilks, Professor and President of the American Psychiatric Nurses Association, joins with insight on what goes into being a psychiatric nurse.  Highlights in “The Role Nurses Play in Schizophrenia Treatment” Episode [01:14] Doctor sidekicks? [04:00] The types of nurses [06:40] Nurse Practitioners [11:00] Nurses specialties [13:00] Psychiatric Nursing [1...
Source: World of Psychology - May 20, 2020 Category: Psychiatry & Psychology Authors: Rachel Star Withers Tags: Inside Schizophrenia Mental Health and Wellness Psychiatry Psychology Mental Disorder Mental Illness Nurses Nursing Psychiatric Nurse Psychotherapy Treatment For Schizophrenia Source Type: blogs

On Stress, Yoga Meditation, and The Evolution Revolution
In the Tale of Two Cities, Charles Dickens wrote: “It was the best of times, it was the worst of times. It was the age of wisdom, it was the age of foolishness…. It was the season of light, it was the season of darkness. It was the spring of hope, it was the winter of despair” Yes, the period of which Dickens wrote is a lot like the present day. We are living through extraordinary times in a complicated world. In my 74 ½ years, I’ve never seen anything like it — from the virus to political strife to protests, stress is rampant. Stress may impact negatively virtually every system of our body, from the immune sy...
Source: SharpBrains - August 14, 2020 Category: Neuroscience Authors: Dr. Dharma Singh Khalsa at Alzheimer's Research & Prevention Foundation Tags: Cognitive Neuroscience Health & Wellness anxiety chronic-stress depression immune system insomnia Kirtan-Kriya lower cognitive ability mbsr meditation mental health Mindfulness-Based-Stress-Reduction telomere Transcendental Med Source Type: blogs

Update on the aducanumab (Aduhelm) saga, retirement, financial advice, cognitive health, excessive worrying, neurotech, and more
Welcome to a new edition of SharpBrains’ e‑newsletter, providing this time a summary of the saga around the FDA approval of aducanumab (Aduhelm) as a supposed treatment for Alzheimer’s Disease, plus a range of timely research findings and resources for lifelong brain health. First, below are some key reads to navigate “probably the worst drug approval decision in recent U.S. history” — Dr. Aaron Kesselheim, the Professor of Medicine at Harvard Medical School who resigned rom the FDA Advisory Committee in protest. #1. Growing backlash against the FDA approval of unproven Alzheimer’s tr...
Source: SharpBrains - June 30, 2021 Category: Neuroscience Authors: SharpBrains Tags: Brain/ Mental Health Education & Lifelong Learning SharpBrains Monthly eNewsletter Technology & Innovation aducanumab Aduhelm Alzheimers-disease anti-amyloid drug Biogen Brain Teasers brain-teaser cognitive decline cognitive-exerci Source Type: blogs