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Can vaping help you quit smoking?
It’s hard to overstate the dangers of smoking. Nearly 500,000 people die of tobacco-related disease each year in the US. Over the next decade, estimates are that around eight million people will die prematurely worldwide each year due to tobacco use. The list of tobacco-related diseases and conditions is long and growing. It includes: cardiovascular disease, including heart attack and stroke emphysema, bronchitis, and asthma lung and other types of cancer tooth decay weathering of the skin having a low-birthweight baby diabetes eye damage (including cataracts and macular degeneration). And there are others. The point i...
Source: Harvard Health Blog - February 27, 2019 Category: Consumer Health News Authors: Robert H. Shmerling, MD Tags: Health Prevention Smoking cessation Source Type: blogs

Digesting ten unpalatable myths about food
I’ve put together a menu of my favourite food myths #DeceivedWisdom and separated the fact and fiction based on the debunking of nutrition myths in a recent well-referenced feature on examine.com. Myth 10 is my own bonus myth debunked. Myth 1: Carbs are bad for you Fact: As long as you do not overindulge, there is nothing inherently harmful about carbohydrates. Myth 2: Fat is bad for you Fact: If you eat too much and don’t get enough exercise, and so stay in a caloric surplus, a low-fat diet won’t help you lose weight. You need some omega-3 and omega-6 fatty acids. Saturated fat won’t give you a heart attac...
Source: David Bradley Sciencebase - Songs, Snaps, Science - February 25, 2019 Category: Science Authors: David Bradley Tags: Sciencebase Source Type: blogs

Fight Aging! Newsletter, February 18th 2019
This study showed that potential vicious cycles underlying ARDs are quite diverse and unique, triggered by diverse and unique factors that do not usually progress with age, thus casting doubts on the possibility of discovering the single molecular cause of aging and developing the single anti-aging pill. Rather, each disease appears to require an individual approach. However, it still cannot be excluded that some or all of these cycles are triggered by fundamental processes of aging, such as chronic inflammation or accumulation of senescent cells. Nevertheless, experimental data showing clear cause and effect relationships...
Source: Fight Aging! - February 17, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Clearance of Senescent Cells Reverses Cardiac Fibrosis and Hypertrophy in Mice
Cells become senescent in response to a toxic environment, or during regeneration, or when damaged in ways that may increase cancer risk, but the vast majority are created when cells reach the end of their replicative life span, the Hayflick limit. Senescence is irreversible, and a senescent cell is blocked from further replication. In all these cases, near all newly senescent cells are soon destroyed, either by their own programmed cell death mechanisms, or by the immune system. A tiny fraction lingers, however. Senescent cells are very metabolically active, secreting a potent mix of molecules that disrupts tissue structu...
Source: Fight Aging! - February 11, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Top Smart Algorithms In Healthcare
As artificial intelligence tools have been invading more or less every area of healthcare, we made a list to keep track of the top smart algorithms aiming for better diagnostics, more sophisticated patient care or further sighted predictions of diseases. Does A.I. beat doctors? Only if you lived under a rock for the last couple of years, could you not have heard about artificial intelligence. Some might have even come across the spread and potential of A.I. in healthcare. Not only smart algorithms themselves but also the hype around A.I. has grown immensely, thus every time a new study about deep learning or machine...
Source: The Medical Futurist - February 5, 2019 Category: Information Technology Authors: nora Tags: Artificial Intelligence in Medicine AI cancer death future Health Healthcare pathology prediction Radiology technology Source Type: blogs

Fight Aging! Newsletter, February 4th 2019
In this study, we examined the benefits of early-onset, lifelong AET on predictors of health, inflammation, and cancer incidence in a naturally aging mouse model. Lifelong, voluntary wheel-running (O-AET; 26-month-old) prevented age-related declines in aerobic fitness and motor coordination vs. age-matched, sedentary controls (O-SED). AET also provided partial protection against sarcopenia, dynapenia, testicular atrophy, and overall organ pathology, hence augmenting the 'physiologic reserve' of lifelong runners. Systemic inflammation, as evidenced by a chronic elevation in 17 of 18 pro- and anti-inflammatory cytokin...
Source: Fight Aging! - February 3, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Ten reasons to NEVER eat gluten-free processed foods
. It saddens me: As popular as the Wheat Belly books and lifestyle have been, there are still millions of people who say things like “Oh, that Wheat Belly thing is just about being gluten-free.” They couldn’t be more wrong and have clearly not read any of the books. Yes, you can be gluten-free and consume foods that naturally have no gluten, gliadin, wheat germ agglutinin, amylopectin A, phytates, and the rest of the toxic components contained in wheat and related grains. You can eat apples, bacon, eggs, and salmon that are naturally gluten-free. You can drink water or tea that is gluten-free. No problems...
Source: Wheat Belly Blog - February 1, 2019 Category: Cardiology Authors: Dr. Davis Tags: News & Updates gluten gluten-free grain-free grains wheat belly Source Type: blogs

The Goal of Symbiotic Microbes in Tissues, Generating Additional Oxygen as Required
We live in an era of biotechnology, of tremendous year by year increases in the capacity to engineer the fundamental mechanisms of life and disease. The research community and funding institutions should aim high, aim at the new and the amazing, rather than slouching forward in the service of crafting yet more marginal, incremental improvements to existing forms of therapy. Sadly, mediocrity rules when it comes to all too much of the research community. Vision is lacking, and far too few people are willing to tread the roads yet untraveled. Why is it necessary to spend so much time and effort to convince people to f...
Source: Fight Aging! - January 31, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

CXCL12 Promotes Small Artery Growth in Injured Hearts, but Why Not Apply this Approach in Advance of Injury as Well?
While rejuvenation research aims at a world in which no-one ever suffers coronary artery disease or a heart attack, the causes of those conditions prevented and controlled, we still live in a world in which these conditions are accepted as inevitable, and the near term focus of regenerative medicine is structural repair for the survivors after the fact. This is a poor second best, but the research community continues to develop ever better potential means of repair. In this case, in which researchers provoke greater construction of secondary arteries that can support the primary blood vessels of the heart, capable of suppl...
Source: Fight Aging! - January 30, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, January 21st 2019
In this study, scientists screened cells from old animals to identify any RBPs that change upon aging. The screening showed that one particular protein, Pumilio2 (PUM2), was highly induced in old animals. PUM2 binds mRNA molecules containing specific recognition sites. Upon its binding, PUM2 represses the translation of the target mRNAs into proteins. Using a systems genetics approach, the researchers then identified a new mRNA target that PUM2 binds. The mRNA encodes for a protein called Mitochondrial Fission Factor (MFF), and is a pivotal regulator of mitochondrial fission - a process by which mitochondria break u...
Source: Fight Aging! - January 20, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Asking Patients To Draw Their Illness Can Be Surprisingly Revealing
“an adult’s perceptions of how the heart has been affected by damage and blockages following a heart attack” – from Broadbent et al 2018 / 2004 By Christian Jarrett Asking patients to draw the parts of their body affected by illness (and similar drawing challenges) can provide insights into how they think about their illness, the seriousness of their condition, and how well they are likely to cope, among other things. For instance, when people who had experienced a heart attack were asked on repeated occasions to draw their heart, an increase in the size of their drawings over time correlated with more anxi...
Source: BPS RESEARCH DIGEST - January 17, 2019 Category: Psychiatry & Psychology Authors: BPS Research Digest Tags: Health Source Type: blogs

Fight Aging! Newsletter, January 14th 2019
In conclusion, reduction of LDL-C to less than 50 mg/dl seems safe and provides greater CV benefits compared with higher levels. Data for achieved LDL-C lower than 20-25 mg/dl is limited, although findings from the above mentioned studies are encouraging. However, further evaluation is needed for future studies and post-hoc analyses. Wary of the Beautiful Fairy Tale of Near Term Rejuvenation https://www.fightaging.org/archives/2019/01/wary-of-the-beautiful-fairy-tale-of-near-term-rejuvenation/ One might compare this interview with researcher Leonid Peshkin to last year's discussion with Vadim Gladyshev. ...
Source: Fight Aging! - January 13, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

LESS BAD is not necessarily GOOD
One of the reasons why the Wheat Belly lifestyle is so spectacularly effective for restoring health, losing weight, and turning back the clock a decade or two is because we reject the flawed logic of conventional nutritional advice. There is a long list of reasons why conventional nutritional advice gets it so wrong, from logical blunders, to relying on flawed observational evidence (rather than clinical trials), to getting too cozy with Big Food companies like Coca Cola and Kraft. Let’s discuss a common and widely-held blunder in logic that is applied over and over again in nutrition: If something bad is replaced by...
Source: Wheat Belly Blog - January 8, 2019 Category: Cardiology Authors: Dr. Davis Tags: News & Updates gluten-free grain-free grains undoctored wheat belly Source Type: blogs

Fight Aging! Newsletter, December 24th 2018
In conclusion, we found a gradient of increasing blood pressure with higher levels of BMI. The fact that this gradient is present even in the fully adjusted analyses suggests that BMI may cause a direct effect on blood pressure, independent of other clinical risk factors. PRRX1 as a Possible Point of Control for Remyelination https://www.fightaging.org/archives/2018/12/prrx1-as-a-possible-point-of-control-for-remyelination/ Researchers here outline what is possibly a new point of intervention in the processes that maintain the myelin sheath that wraps nerves. This sheath is vital to the correct operatio...
Source: Fight Aging! - December 23, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs