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Fight Aging! Newsletter, March 25th 2019
This study defines a new clinically relevant concept of T-cell senescence-mediated inflammatory responses in the pathophysiology of abnormal glucose homeostasis. We also found that T-cell senescence is associated with systemic inflammation and alters hepatic glucose homeostasis. The rational modulation of T-cell senescence would be a promising avenue for the treatment or prevention of diabetes. Intron Retention via Alternative Splicing as a Signature of Aging https://www.fightaging.org/archives/2019/03/intron-retention-via-alternative-splicing-as-a-signature-of-aging/ In recent years researchers have inv...
Source: Fight Aging! - March 24, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

How To Go Beyond The Airline Medical Kit To Keep Passengers Healthy In The Future?
Humanity has come a long way from treating patients who have fallen off cliffs after having tried to fly, dressed like birds: parallel to the development of flying, the practice of how to keep people alive during flights has also greatly evolved. How can digital health add to the practice of aviation medicine in the future and make sure that passengers step off the plane as healthy as they got in? From Icarus through hot air balloons to mid-air meditation The human desire to conquer the sky is a thousand-year-old story, with tales such as the Greek myth about Daedalus and Icarus. The duo wanted to escape from Crete,...
Source: The Medical Futurist - March 21, 2019 Category: Information Technology Authors: nora Tags: Future of Medicine Health Sensors & Trackers aero aeronautics aviation emergency emergency medicine flight flight medicine Healthcare portable portable diagnostics predictive prevention technology wearables Source Type: blogs

Over-the-counter cold and flu medicines can affect your heart
As the cold and flu season continues this year, it is important to be aware that many of the most commonly used over-the-counter (OTC) remedies for congestion, aches, pains, and low-grade fevers contain medicines that can have harmful effects on the cardiovascular system. Chief among these medications are nonsteroidal anti-inflammatory drugs (NSAIDs) and decongestants. NSAIDs and your heart Certain NSAIDs are associated with a small increase in the relative risk for developing a heart attack, stroke, heart failure, atrial fibrillation, increased blood pressure, and blood clots. NSAIDs relieve pain and inflammation by inhib...
Source: Harvard Health Blog - March 20, 2019 Category: Consumer Health News Authors: Mark Benson, MD, PhD Tags: Cold and Flu Drugs and Supplements Health Heart Health Source Type: blogs

Improvement in Heart Attack Incidence and Outcomes Over the Past Twenty Years
The story of the past few decades has been a steady reduction in the incidence and mortality of the major age-related diseases that dominated old age in the last century. This has been a strange triumph, in the sense that it was achieved using very inefficient strategies for medical research and development, coupled with an aggressive push towards prevention through lifestyle choice. At no point were the causes of aging deliberately targeted; instead medical efforts focused on tinkering with the downstream consequences of the late disease state. That this combination nonetheless achieved the results that it did is a testam...
Source: Fight Aging! - March 18, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Purported Links Between Vaping and Heart Attacks are Based on Crappy Science
This study, being presented tomorrow (Monday) morning at the annual meeting of the American College of Cardiology in New Orleans, reports that " adults who report puffing e-cigarettes, or vaping, are significantly more likely to have a heart attack, coronary artery disease and depression compared with those who don ’t use them or any tobacco products. "These conclusions were based on a cross-sectional analysis of data from the 2014, 2016, and 2017 National Health Interview Surveys. Respondents were asked to report whether they had ever been diagnosed with having had a heart attack, coronary artery disease, or depression....
Source: The Rest of the Story: Tobacco News Analysis and Commentary - March 18, 2019 Category: Addiction Source Type: blogs

ISCHEMIA Trial baseline data
International Study of Comparative Health Effectiveness With Medical and Invasive Approaches (ISCHEMIA) trial was sponsored by the New York University School of Medicine. Collaborators include National Heart, Lung, and Blood Institute (NHLBI), Stanford University, Duke University, Emory University, Harvard University and several other leading institutions. ISCHEMIA trial randomized 5179 patients with stable ischemic heart disease with moderate to severe degree of inducible ischemia on stress testing. Blinded CT coronary angiogram was used to exclude those with significant unprotected left main coronary artery disease or ...
Source: Cardiophile MD - March 16, 2019 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiology Source Type: blogs

Aspirin for primary prevention of cardiovascular disease, part 2
Update In March 2019, the American College of Cardiology (ACC) and the American Heart Association (AHA) released new guidelines that suggest that most adults without a history of heart disease should not take low-dose daily aspirin to prevent a first heart attack or stroke. Based on the ASPREE, ARRIVE, and ASCEND trials, the ACC/AHA guidelines concluded that the risk of side effects from aspirin, particularly bleeding, outweighed the potential benefit. The new guidelines do not pertain to people with established cardiovascular disease, in whom the benefits of daily aspirin have been found to outweigh the risks. ___________...
Source: Harvard Health Blog - March 14, 2019 Category: Consumer Health News Authors: Deepak Bhatt, MD, MPH Tags: Heart Health Prevention Source Type: blogs

The Heart of The Matter: Technology In The Future of Cardiology
Sound, rhythm, rate, structure, function – countless features of the heart are measured to keep it healthy for as long as possible. Recently, an army of digital health technologies joined the forces of traditional preventive tools in cardiology to counter stroke, heart attack, heart failure or any other cardiovascular risks. In the future, minuscule sensors, digital twins, and artificial intelligence could strengthen their ranks. Let’s see what the future of cardiology might look like! Fitness trackers, chatbots and A.I. against heart disease Let’s say 36-year-old Maria living in Sao Paulo in 2033 decides one d...
Source: The Medical Futurist - March 12, 2019 Category: Information Technology Authors: nora Tags: Artificial Intelligence in Medicine Future of Medicine Health Sensors & Trackers Portable Diagnostics cardiology cardiovascular cardiovascular diseases digital digital twin health trackers heart heart health heart rate heart soun Source Type: blogs

What will you do for this patient transferred to you who is now asymptomatic?
A middle-aged woman with history of hypertension presented to another hospital approximately 2 hours after onset of chest pain and shortness of breath.This ECG was recorded on arrival:What do you think?This is technically a STEMI, with 1.5 mm STE in V1 and 1.5-2.0 mm in V2. The current criteria only require 1mm in V1 and 1.5mm in V2 for a female. However, I think many practitioners might not see this as a clear STEMI, and would instead call this " borderline. " The normal QRS complex with STE and large volume underneath the T-waves in V1-V3 confirm Occlusion MI (OMI). There is not technically STD in V6 and I, however the m...
Source: Dr. Smith's ECG Blog - March 5, 2019 Category: Cardiology Authors: Pendell Source Type: blogs

Papillary muscles – echocardiogram
Papillary muscles – echocardiogram IVS: Interventricular septum Echocardiogram from parasternal short axis view showing the two papillary muscles in the left ventricle (posteromedial and anterolateral). Papillary muscles form part of the mitral valve apparatus which prevent bulging back of the mitral leaflets during systole and thus avoiding mitral regurgitation. When the papillary muscles are ischemic and dysfunctional it results in mitral regurgitation due to papillary muscle dysfunction. If the head of the papillary muscle gets necrosed and ruptures in acute myocardial infarction, it results in acute severe mitra...
Source: Cardiophile MD - March 3, 2019 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiology catheter ablation Source Type: blogs

BIOTRONIK ’s Orsiro Ultrathin Coronary Stent Approved in U.S.
BIOTRONIK won FDA approval for its Orsiro drug-eluting coronary stent, an ultrathin device that’s already been approved in Europe for eight years and has been implanted in more than a million patients worldwide. The Orsiro is a cobalt chromium ...
Source: Medgadget - February 25, 2019 Category: Medical Devices Authors: Editors Tags: Cardiology Source Type: blogs

An ER Doctor Answers Our Questions About End-of-Life Care
...Dr. Kevin Haselhorst: Life changing, yes! And perhaps a moment of divine intervention. An elderly man with COPD (chronic obstructive pulmonary disease) was rushed to the cardiac cath lab after being diagnosed with an acute myocardial infarction (MI). He was struggling to breathe, yet pleaded with me to not insert the breathing tube and to let him die. The cardiologist was scared to do it. With a voice coming from above saying, “Let My People Go!” I honored the man’s wishes. I tremble every time I read this passage. Read the full article on HealthCentral for answers from an ER doctor about end-of-life c...
Source: Minding Our Elders - February 22, 2019 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs

How much time are you willing to wait for OMI to become STEMI (if it ever does)?
Written by Pendell Meyers, few edits by SmithA man in his 60s with history of stroke and hypertension but no known heart disease presented with chest pain that started on the morning of presentation at around 8am.Here is his triage ECG when he presented at 1657:What do you think?There is sinus rhythm with normal QRS complex and ST depression in V2-V5, maximal in V3-V4. There is no ST depression in V6, II, III, or aVF, and no significant ST elevation in aVR, all confirming that the ST vector is not consistent with diffuse subendocardial ischemia, but rather a focal ST vector pointed at the posterior wall. It is posterior OM...
Source: Dr. Smith's ECG Blog - February 16, 2019 Category: Cardiology Authors: Pendell Source Type: blogs

A positive mindset can help your heart
Can being positive protect against heart disease? Yes! There is a lot of evidence suggesting that having a positive outlook — like being optimistic, cheerful, having gratitude and purpose in life — can be heart-protective. Researchers in the UK looked at psychological characteristics of over 8,000 people, and found that those who scored high on optimism and a sense of well-being enjoyed a 30% lower risk of developing heart disease. Other studies report similar findings: in a study of over 70,000 women followed for over 10 years, those who scored highest on an optimism questionnaire had a significantly lower risk of dea...
Source: Harvard Health Blog - February 14, 2019 Category: Consumer Health News Authors: Monique Tello, MD, MPH Tags: Heart Health Mind body medicine Source Type: blogs

Critical gaps in STEMI knowledge base : What is the relationship between “ Time window ” and “ Age ” of IRA thrombus ?
Cardiologists are grappling with at least  half a dozen time windows  in the management of STEMI. (It can be combinations of any of the following :Symptom – DAPT Loading – Door – Needle /Balloon-Sheath, wire crossing etc ) Time windows are Important in choosing the right (or no)modality of re-perfusion . Though superiority of  primary PCI  is thought to be established in academic community , it  may not be in real world. Published studies that suggest pPCI is superior to lysis at any time window  still lack good evidence. Why is this long drawn confusion  ?  One of the important determinant of...
Source: Dr.S.Venkatesan MD - February 9, 2019 Category: Cardiology Authors: dr s venkatesan Tags: cath lab tips and tricks PCI PTCA Hardware Primary -PCI STEMI STEMI -Managment STEMI-Primary PCI Thrombolysis how to estimate the age of thrombus in stemi acs soft vs hard thrombus in stemi thrombus hardening time thrombus organising t Source Type: blogs