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Fight Aging! Newsletter, June 20th 2022
This study showed a negative relationship between the gaps and the number of senescence cells. Moreover, we found a similar reduction in 30-month-old naturally and 7-month-old D-gal-induced aging rats. Given these consistent data from different eukaryotic organisms, it suggests that the Youth-DNA-GAP is a marker of phenotype-related aging degree
Towards Scaffold-Based Regeneration of Dental Pulp
https://www.fightaging.org/archives/2022/06/towards-scaffold-based-regeneration-of-dental-pulp/
Researchers are working towards the ability to regenerate the dental pulp inside teeth. Full regeneration of teeth h...
Source: Fight Aging! - June 19, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Lipid Nanodiscs Unlock the Potential of Cytokine Treatment
Researchers at the University of Texas at Austin created a nanocarrier for stem cell factor, a regenerative cytokine. The nanotechnological approach renders the treatment much safer, as previous attempts to use stem cell factor as a pro-angiogenic tr...
Source: Medgadget - June 13, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Cardiac Surgery Cardiology Medicine Nanomedicine Source Type: blogs
Chest pain, trop > 50,000 but only 30% LAD stenosis on angiogram: what ' s the diagnosis?
Conclusion: Correlation of the recurrence of this patient ' s chest pain with evolving ECG changes (loss of anterior R waves, waxing and waning of Q waves — and dynamic change in shape and relative amount of ST segment deviation) — was enough to justify the determination of an " acute STEMI " despite no more than borderline ECG criteria for this diagnosis and non-obstructive coronary disease on 2 catheterizations. Clinically — Stenting of the non-obstructive 60% mid-LAD lesion effectively prevented further infarction. Dependence on mill...
Source: Dr. Smith's ECG Blog - June 5, 2022 Category: Cardiology Authors: Jesse McLaren Source Type: blogs
Chest pain, shortness of breath, T wave inversion, and rising troponin in a young healthy runner.
In this study, 40 presumably healthy male marathon runners had their cardiac troponin and other findings measured before and after running a marathon. 39 pts (97.5%) had baseline cTnT values below the reference limit (less than 14 ng/L). 38 pts (95%) of participants had post-marathon cTnT concentration rise above this reference limit. The median post-marathon cTnT was 41 ng/L, and the 95th percentile concentration was 90 ng/L. None reported " cardiac symptoms " after the race.See this single post for many examples of BTWI:Understanding this pathognomonic ECG would have greatly benefitted the patient.More cases involving BT...
Source: Dr. Smith's ECG Blog - May 19, 2022 Category: Cardiology Authors: Pendell Source Type: blogs
A man in his 40s who really needs you to understand his ECG
Written by Pendell MeyersA man in his 40s presented for " left sided chest pain sudden onset yesterday when sneezing and coughing that is worsened with inspiration. " He also complained of associated SOB, dizziness, jaw pain, and back pain, which he described as " muscle spasms. " He has also had rhinorrhea and cough for 1 week. Also, left hand numbness today. He went to urgent care for evaluation. An ECG was performed there (unavailable) which reportedly was abnormal, so EMS was called to urgent care to take him to the ED.On EMS arrival, they noted the patient vomited then became unresponsive. He was reportedly...
Source: Dr. Smith's ECG Blog - May 1, 2022 Category: Cardiology Authors: Pendell Source Type: blogs
A man in his 40s with RUQ abdominal pain
Conclusion:In hemodynamically stable patients with chest pain, sinus tachycardia aids in the identification of patients unlikely to have type I MI, especially in those with HR greater than 120 bpm.===================================MY Comment by KEN GRAUER, MD (4/28/2020):===================================Insightful case presented by Drs. Goss and Meyers highlighting the importance of recognizing the ECG signs of acute PE. I focus my comments on further dissecting some of these " tell-tale " ECG features.The " theme " of today ' s case was "pattern recognition". Like the ECG diagnos...
Source: Dr. Smith's ECG Blog - April 28, 2022 Category: Cardiology Authors: Pendell Source Type: blogs
Chest pain, a ‘normal’ ECG, a ' normal trop ' , and low HEART and EDACS scores: Discharge home? Stress test? Many errors here.
Written by Jesse McLaren, with comments from Smith and GrauerA 60 year old presented with three weeks of intermittent non-exertional chest pain without associated symptoms. ECG was labeled ‘normal’ by the computer (confirmed by the overreading cardiologist) and the high-sensitivity Troponin I was normal at a value of 11 ng/L (Abbott Alinity assay, where normal is<26 in males,<16 in females; this assay is nearly identical to the Abbott Architect high sensitivity assay). So the patient was low risk according to HEART and EDACS scores. Should this patient be discharged home? How about a stress test? ...
Source: Dr. Smith's ECG Blog - April 22, 2022 Category: Cardiology Authors: Jesse McLaren Source Type: blogs
A man in his 50s with acute chest pain and history of prior MI
Written by Pendell MeyersA man in his 50s with prior history of anterior MI with LAD stent presented with acute chest pain similar but more intense than his last MI. He presented around midnight with pain that had started around 9pm the night before. He had taken NTG at home with no improvement, and immediately received morphine on arrival at the ED for severe chest pain (a very bad idea if your accuracy for finding OMI on ECG is low, since ongoing pain will be your last chance to identify those with ongoing untreated OMI).Here is his triage ECG at 0012:What do you think? What is the differential of this ECG?There is sinus...
Source: Dr. Smith's ECG Blog - April 13, 2022 Category: Cardiology Authors: Pendell Source Type: blogs
A woman in her 30s with sudden chest pain, nausea, and diaphoresis. Was her cardiology management appropriate?
Case written and submitted by Brandon Fetterolf MD, edits by MeyersA woman in her early 30s with multiple autoimmune disorders including vasculitis presented with 2-3 hours of mid-left side chest discomfort with radiation to neck and left arm and associated with nausea, diaphoresis and dizziness. Initial ECG on presentation at 1554 (no prior for comparison):What do you think is happening to his 30s woman? The ECG shows NSR with a normal QRS except for poor R wave progression and pathologic QS-waves in V2-3. There is STE and hyperacute T waves in V2, I, and aVL with reciprocal STD in II, III, and aVF. This is...
Source: Dr. Smith's ECG Blog - April 8, 2022 Category: Cardiology Authors: Pendell Source Type: blogs
Chest pain + troponin of 1600 + LBBB + 6mm ST elevation = occlusion MI, right?
This case is by Jesse McLaren (@ECGCases), with comments by Smith and GrauerA 50 year-old with CAD and ESRD went to their regular hemodialysis appointment complaining of two days of exertional chest pain. The patient was sent to the ED when high-sensitivity Troponin I returned at 1,526 ng/L (normal<26 in males,<16 in females). They were painfree on arrival, with BP 180/70 and other vitals normal. What do you think? There ’s sinus rhythm with LBBB and appropriate discordant ST changes: there’s no concordant ST elevation, no concordant ST depression in V1-3, and no excessive discordance...
Source: Dr. Smith's ECG Blog - March 31, 2022 Category: Cardiology Authors: Jesse McLaren Source Type: blogs
Is there evidence of OMI on this ECG?
This is another one from Amandeep ( " Deep " ) Singh, with many comments by Smith. Dept Emergency Medicine, Highland Hospital, Oakland.Case67yo male with h/o schizophrenia and who has become increasingly distrustful of Western medicine presents with chest pain radiating to the right shoulder associated with shortness of breath for 24 hours duration. He states that he was unable to sleep secondary to the pain. The patient seems very worried about his right shoulder and is requesting a x-ray. An x-ray was obtained, as well as an ECG and a troponin. Prior to the trop...
Source: Dr. Smith's ECG Blog - March 26, 2022 Category: Cardiology Authors: Steve Smith Source Type: blogs
Smartphone App Calculates Genetic Risk of Coronary Artery Disease
Researchers at the Scripps Research Institute in California have developed a smartphone app that can calculate a user’s genetic risk of coronary artery disease. The app can import genetic information from a commonly used genetic testing service, 23...
Source: Medgadget - March 25, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Cardiology Diagnostics Informatics scripps Source Type: blogs
False cath lab activation or false cancellation?
Written by Jesse McLarenA 40 year old developed sudden chest pain radiating to the jaw, with diaphoresis and vomiting. What do you think?What do you think? There ’s normal sinus rhythm with normal conduction, normal axis, normal R wave progression and normal voltages. There are hyperacute T wave in I/aVL and possibly V5-6, with reciprocal change in III. There’s also ST depression in V1-3. The computer interpretation labeled this ECG as “nonspecific”, and it does not meet STEMI criteria. But there are ischemic abnormalities in the majority of leads that add up to an ECG diagnostic of posterolateral Occlusion MI...
Source: Dr. Smith's ECG Blog - March 16, 2022 Category: Cardiology Authors: Jesse McLaren Source Type: blogs
Missing ECG signs of OMI is associated with early death
Written by Sean Trostel MD, with edits by Smith and MeyersA man in his 80s with history of CAD, MI s/p PCI, HTN, HLD, Afib, and HFrEF, presented with sudden onset, aching, central chest pain radiating to the left arm and shortness of breath that began in the morning, 1 hour prior to arrival to the ED. This was his initial triage ECG, recorded one hour after onset of symptoms, and a baseline ECG below for comparison:What do you think?Baseline on file: This ECG was interpreted as sinus bradycardia with no acute ST or T wave changes compared to prior. Despite the very poor quality and wanderin...
Source: Dr. Smith's ECG Blog - February 25, 2022 Category: Cardiology Authors: Pendell Source Type: blogs
Occlusion/reperfusion through 6 ‘normal’ ECGs
This is written and contributed by Jesse McLaren (@ECGCases), with comments and edits by Smith, and commentary by Ken Grauer (@EKGPress)An 80 year-old female presented with weakness and a fall, with normal vitals and no injuries. The ECG was labeled ‘normal’ by the computer, later confirmed by the cardiologist. What do you think? There ’s normal sinus rhythm, normal conduction, normal axis, normal R wave progression, and normal voltages. There’s usually a small amount of concave ST elevation in V2-3 but here there is horizontal ST depression in V2 and possibly V1. Smith: without any furt...
Source: Dr. Smith's ECG Blog - February 10, 2022 Category: Cardiology Authors: Jesse McLaren Source Type: blogs
