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Condition: Obesity
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Total 911 results found since Jan 2013.
Development of a Safe Mitochondrial Uncoupler, OPC-163493
We describe here the optimization process from initial screening hit compound to a liver-localized mitochondrial uncoupler OPC-163493, which recently demonstrated its potent antidiabetic and cardiovascular beneficial effects with acceptable safety.
Link: https://doi.org/10.1021/acsomega.1c01993
Source: Fight Aging! - July 21, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
A case for changing the way we talk about obesity
You are finger. No, I have fingers. You are leg. No, I have legs. You are pancreas. No, I have a pancreas. You are fat. Hmm … Now let’s try this with disease processes: You are diabetes. No, I have diabetes. You are cancer. No, I have cancer. You are anorexia. No, I have anorexia.Read more …A case for changing the way we talk about obesity originally appeared inKevinMD.com.
Source: Kevin, M.D. - Medical Weblog - July 16, 2021 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/jill-becker" rel="tag" > Jill Becker, MD < /a > < /span > Tags: Conditions Obesity Source Type: blogs
Life sciences vision
Department for Business, Energy& Industrial Strategy - This document outlines government and the life science sector ’s ambitions for the sector over the next decade. It sets out the government's plans to stimulate a thriving UK life sciences sector. It also focuses on how the sector can address the some of the UK ’s most significant healthcare challenges, including cancer, dementia, and obesity.DocumentPress release
Source: Health Management Specialist Library - July 12, 2021 Category: UK Health Authors: The King ' s Fund Library Tags: Digital health and data Source Type: blogs
Fight Aging! Newsletter, July 12th 2021
In conclusion, our study demonstrated that elevated cumulative SBP or DBP was independently associated with increased risk of CVD in the Chinese population. Among participants with 15-year cumulative BP levels higher than the median, that is, 1970.8/1239.9 mmHg-year for cumulative SBP/DBP, which was equivalent to maintaining SBP/DBP level higher than 131/83 mmHg in 15 years, the CVD risk would increase significantly irrespective of whether or not the BP measurements at one examination was high. Our findings emphasize the importance of cumulative BP level in identifying individuals with high risk of CVD in the future.
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Source: Fight Aging! - July 11, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, July 5th 2021
In conclusion, the findings suggest that DNAm GrimAge is a strong predictor of mortality independent of genetic influences.
Heart Failure Correlates with Increased Cancer Risk
https://www.fightaging.org/archives/2021/07/heart-failure-correlates-with-increased-cancer-risk/
Age-related disease results from the underlying cell and tissue damage that causes aging. Different people accumulate that damage at modestly different rates, the result of lifestyle choices and exposure to infectious disease. Thus the presence of a sufficient burden of damage to produce one age-related disease will be accompanied by a ...
Source: Fight Aging! - July 4, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Heart Failure Correlates with Increased Cancer Risk
Age-related disease results from the underlying cell and tissue damage that causes aging. Different people accumulate that damage at modestly different rates, the result of lifestyle choices and exposure to infectious disease. Thus the presence of a sufficient burden of damage to produce one age-related disease will be accompanied by a raised risk of other age-related conditions. The conditions themselves need not have any direct relationship with one another, but can be distinct outcomes of the same root causes. Here, however, researchers propose that heart failure may provoke increased cancer risk via inflammatory and ot...
Source: Fight Aging! - July 1, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Mobility-Enabled Compression Device for Lymphedema: Interview with CEO of Koya Medical
Koya Medical, a medtech company based in California, has developed the Dayspring active compression system for the treatment of lymphedema. The company received FDA clearance for the use of Dayspring on the upper extremities in June 2020, and just re...
Source: Medgadget - June 23, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Exclusive Surgery Vascular Surgery Source Type: blogs
Fight Aging! Newsletter, June 21st 2021
This study showed that the leakage of this mitochondrial nucleic material may occur as a result of mitochondrial dysfunction, which may involve genetic mutations in genes encoding mitochondrial proteins or incomplete degradation of mitochondrial dsDNA in the lysosome - which is a 'degradation factory' of the cell. Upon the leakage into the cytoplasm, this undegraded dsDNA is detected by a 'foreign' DNA sensor of the cytoplasm (IFI16) which then triggers the upregulation of mRNAs encoding for inflammatory proteins."
Using a PD zebrafish model (gba mutant), the researchers demonstrated that a combination of PD-like ph...
Source: Fight Aging! - June 20, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
How Big Pharma Bought Big Media for $6 Billion: The Unintended Consequences of Direct-to-Consumer Drug Advertising
Media, whether broadcast, streamed, or print, is a lifeline of information for most Americans. Updates on the pandemic, results of an election, knowing whether you are in the path of an oncoming hurricane or snowstorm—we are alerted by news reports and thereby dependent on the factual information they provide. Media informs, shapes opinions, keeps us out of harm’s way. Despite the public pummeling media has received over the past few years, media remains the means through which Americans view much of their world. What the media reports—or does not report—is therefore crucial to shaping opinion and behavior.
There...
Source: Wheat Belly Blog - June 18, 2021 Category: Cardiology Authors: Dr. Davis Tags: Open undoctored wheat belly Source Type: blogs
Fight Aging! Newsletter, June 14th 2021
In conclusion, a number of high-income countries, changes in health expectancies over time have not kept pace with the growth in life expectancy. That is, people are living longer but disability and poor health are occupying an increasing proportion of later life. Our findings suggest that countries still need to make significant progress to achieve the WHO's Decade of Healthy Ageing goal of healthier, longer lives for all.
Progress on Understanding Why Human Growth Hormone Receptor Variants are Associated with Greater Longevity
https://www.fightaging.org/archives/2021/06/progress-on-understanding-why-human-gro...
Source: Fight Aging! - June 13, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, June 7th 2021
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - June 6, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, May 31st 2021
In conclusion, iMSC-sEVs could rejuvenate the senescence of NPCs and attenuate the development of IVDD.
Cell Signaling via Exosomes in the Development of Vascular Calcification
https://www.fightaging.org/archives/2021/05/cell-signaling-via-exosomes-in-the-development-of-vascular-calcification/
Vascular calcification is a feature of aging, a process in which cells in the blood vessel wall take on inappropriate identities and activities that are more appropriate to bone tissue. Evidence of recent years implicates chronic inflammation and the presence of senescent cells in this process. Senescent cells caus...
Source: Fight Aging! - May 30, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, May 24th 2021
In conclusion, we showed that addition of resistance exercise training, but not dietary EAAs, to the myostatin inhibition further increased muscle mass through the attenuation of muscle protein breakdown with proportionate improvements in muscle strength. Interestingly, addition of dietary EAAs to the myostatin inhibition with or without resistance exercise training improved muscle quality. Thus, dissection of the underlying mechanisms behind the combined positive effect of dietary EAAs and resistance exercise training on muscle mass and quality can shed light on the discovery of effective therapeutics against muscle wasti...
Source: Fight Aging! - May 23, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
On Balance, Vegetarians Exhibit Better Biomarkers than Non-Vegetarians
There is a fair amount of epidemiological data to suggest that vegetarians have, on balance, better long-term health prospects than people who consume meat. The usual caveats apply, in that vegetarianism in many wealthier study populations is correlated with a range of other potentially relevant line items, such as education, wealth, and better lifestyle choices. Further, the average vegetarian may well be mildly calorie restricted in comparison to the average meat eater, and that may be enough in and of itself to explain health effects. Other suggested contributing factors include dietary advanced glycation end-products, ...
Source: Fight Aging! - May 18, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
5 inflammation-fighting food swaps
Inflammation: if you follow health news, you probably hear about it often. When is inflammation helpful? How can it be harmful? What steps can you take to tone it down?
What is inflammation and how does it affect your body?
If you’re not familiar with the term, inflammation refers to an immune system reaction to an infection or injury. In those instances, inflammation is a beneficial sign that your body is fighting to repair itself by sending in an army of healing white blood cells. As the injury heals or the illness is brought under control, inflammation subsides. You’ve probably seen this happen with a minor ankle sp...
Source: Harvard Health Blog - May 10, 2021 Category: Consumer Health News Authors: Kelly Bilodeau Tags: Arthritis Autoimmune diseases Health Heart Health Nutrition Source Type: blogs
