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Total 911 results found since Jan 2013.

Exercise as a Mild Senotherapeutic
Exercise is known to improve health and extend the healthy portion of life span, but not extend life span itself in mice. This is a much lesser effect than that of calorie restriction, which does extend maximum life span in addition to improving health. From a very high level view, both exercise and calorie restriction are similar, in that they trigger many of the same stress response mechanisms, making those mechanisms work harder to maintain cell function than they would otherwise have done. Evidently exercise and calorie restriction achieve this goal in quite different ways at the detail level, given the quite different...
Source: Fight Aging! - January 5, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Fight Aging! Newsletter, January 4th 2021
The objective of this study is to quantify the overall and cancer type-specific risks of subsequent primary cancers (SPCs) among adult-onset cancer survivors by first primary cancer (FPC) types and sex. Among 1,537,101 survivors (mean age, 60.4 years; 48.8% women), 156,442 SPC cases and 88,818 SPC deaths occurred during 11,197,890 person-years of follow-up (mean, 7.3 years). Among men, the overall risk of developing any SPCs was statistically significantly higher for 18 of the 30 FPC types, and risk of dying from any SPCs was statistically significantly higher for 27 of 30 FPC types as compared with risks in the general po...
Source: Fight Aging! - January 3, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

A Look Back at 2020: Progress Towards the Treatment of Aging as a Medical Condition
While I suspect that COVID-19 will feature prominently in most retrospectives on 2020, I'll say only a little on it. The data on mortality by year end, if taken at face value, continues to suggest that the outcome will fall at the higher end of the early estimates of a pandemic three to six times worse than a bad influenza year, ten times worse than a normal influenza year. The people who die are near entirely the old, the co-morbid, and the immunocompromised. They die because they are suffering the damage and dysfunction of aging. Yet the societal conversation and the actions of policy makers ignore this. There is ...
Source: Fight Aging! - December 31, 2020 Category: Research Authors: Reason Tags: Of Interest Source Type: blogs

Cancer Survivors Exhibit Greater Risk of New Cancers and Higher Mortality Due to those Cancers
The objective of this study is to quantify the overall and cancer type-specific risks of subsequent primary cancers (SPCs) among adult-onset cancer survivors by first primary cancer (FPC) types and sex. Among 1,537,101 survivors (mean age, 60.4 years; 48.8% women), 156,442 SPC cases and 88,818 SPC deaths occurred during 11,197,890 person-years of follow-up (mean, 7.3 years). Among men, the overall risk of developing any SPCs was statistically significantly higher for 18 of the 30 FPC types, and risk of dying from any SPCs was statistically significantly higher for 27 of 30 FPC types as compared with risks in the general po...
Source: Fight Aging! - December 29, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Fight Aging! Newsletter, December 28th 2020
In conclusion, our study demonstrated that the molecular processes of aging are relatively subtle in their progress, and the aging process of every tissue depends on the tissue's specialized function and environment. Hence, individual gene or process alone cannot be described as the key of aging in the whole organism. Mouse Age Matters: How Age Affects the Murine Plasma Metabolome A large part of metabolomics research relies on experiments involving mouse models, which are usually 6 to 20 weeks of age. However, in this age range mice undergo dramatic developmental changes. Even small age differences may l...
Source: Fight Aging! - December 27, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, December 21st 2020
In this study, we have found that administration of a specific Sgk1 inhibitor significantly reduces the dysregulated form of tau protein that is a pathological hallmark of AD, restores prefrontal cortical synaptic function, and mitigates memory deficits in an AD model. These results have identified Sgk1 as a potential key target for therapeutic intervention of AD, which may have specific and precise effects." Targeting histone K4 trimethylation for treatment of cognitive and synaptic deficits in mouse models of Alzheimer's disease Epigenetic aberration is implicated in aging and neurodegeneration. Using p...
Source: Fight Aging! - December 20, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Network medicine offers new insights into susceptibility to diseases such as COVID-19
In the past year, we ' ve become familiar with the factors that can make a person more vulnerable to COVID-19 infection. The elderly are more at risk, as are those who smoke and are already dealing with other diseases, such as cancer and Type 2 diabetes.At a deeper level, though, there are dozens of other factors that may come into play and influence a person ' s susceptibility to disease. A recent analysis of hospitalized COVID-19 patients in 14 states found that among patients ages 50-64 that obesity was the most prevalent underlying medical condition. Similarly, there ' s growing evidence to suggest that vitamin D defic...
Source: Life as a Healthcare CIO - December 17, 2020 Category: Information Technology Source Type: blogs

The Quality of Epigenetic Clocks Continues to Improve
There is at present a diverse exploration of clocks that assess biological age, these clocks constructed as weighted combinations of data picked from the epigenome, transcriptome, or proteome, all of which change in characteristic ways with age. Many different clocks are at various stages of development and refinement. The goal is the production of a robust, low-cost, rapid way to assess the efficacy of potential rejuvenation therapies: if one can use a blood test ten days before and ten days after a treatment, that would be a great deal easier than having to wait and see over the course of a life span. Unfortunate...
Source: Fight Aging! - December 16, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Nutritional lessons from the coronavirus pandemic
You’ve heard the headlines: Upon contracting COVID-19, people with various co-morbidities are at increased risk for becoming critically ill, such as developing acute respiratory distress syndrome necessitating mechanical ventilation. They are several-fold more likely to die of the disease, also. Among the most common health conditions that put people at high risk for becoming severely ill include: Obesity Type 2 diabetes Hypertension Coronary disease and heart failure Cerebrovascular disease There are other conditions that also confer increased risk such as smoking, lung disease, and lung cancer. But the four condi...
Source: Wheat Belly Blog - December 14, 2020 Category: Cardiology Authors: Dr. Davis Tags: Open coronavirus covid Inflammation insulin pandemic undoctored wheat belly Source Type: blogs

What is culinary medicine and why do we need it?  
It is no secret that physicians spend countless hours studying a wide variety of disease processes and treatments. We all know that sub-optimal dietary choices and habits can lead to chronic diseases such as obesity, cardiovascular disease, diabetes, and cancer. The burden of these diseases is rising astronomically. According to the USDA 2015-2020 guidelines, in […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more.
Source: Kevin, M.D. - Medical Weblog - December 12, 2020 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/disha-narang-and-nisha-patel" rel="tag" > Disha Narang, MD and Nisha Patel, MD < /a > < /span > Tags: Physician Nutrition Source Type: blogs

What I Got Wrong (and Right) about COVID19
In May, I wrote a column about COVID19 that got some attention. My reason for writing was the change in messaging about the strategy of flatten-the-curve. We were first told to flatten-the-curve to prevent overwhelming hospitals. But then the thinking changed to flatten-the-curve to save lives.  I made eight assertions about COVID19. Let’s see how I did.  Assertion 1: The virus will not be contained. Verdict: Correct. You might argue that New Zealand and Australia contained the virus, but I would counter that these are not fair comparisons to the US, Canada, and the EU.  Assertion 2: Tests...
Source: Dr John M - December 12, 2020 Category: Cardiology Authors: Dr John Source Type: blogs

Fight Aging! Newsletter, December 7th 2020
In this study, except for the reduction in body weight, the aging characteristics related to epidermal and muscle tissue in mice were significantly ameliorated in the CR group compared with the control group. Additional studies have indicated that not stem cells themselves but the stem cell microenvironment is the key factor mediating stem cell activation, proliferation and differentiation. Mitochondrial dysfunction is an important factor leading to age-related muscular atrophy. Considering the dependence of skeletal muscle on ATP, loss of mitochondrial function, which can lead to a decrease in strength and enduranc...
Source: Fight Aging! - December 6, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Teaching Old Cells New Tricks: Insights Into Molecular-Level Aging
When someone mentions aging, you may think of visible changes, like graying hair. Scientists can see signs of aging in cells, too. Understanding how basic cell processes are involved in aging is a first step to help people lead longer, healthier lives. NIGMS-funded researchers are discovering how aging cells change and applying this knowledge to health care. Discovering the Wisdom of Worms C. elegans with a ribosomal protein glowing red and muscle fibers glowing green. Credit: Hannah Somers, Mount Desert Island Biological Laboratory. Aric Rogers, Ph.D., and Jarod Rollins, Ph.D., assistant professors of regenerati...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - December 2, 2020 Category: Research Authors: Chrissa Chverchko Tags: Injury and Illness Cellular Processes Research Roundup Source Type: blogs

Fight Aging! Newsletter, November 23rd 2020
In conclusion, the study indicates that HBOT may induce significant senolytic effects that include significantly increasing telomere length and clearance of senescent cells in the aging populations. Data on the Prevalence of Liver Fibrosis in Middle Age https://www.fightaging.org/archives/2020/11/data-on-the-prevalence-of-liver-fibrosis-in-middle-age/ Fibrosis is a consequence of age-related disarray in tissue maintenance processes, leading to the deposition of scar-like collagen that disrupts tissue structure and function. It is an ultimately fatal issue for which there are only poor treatment options a...
Source: Fight Aging! - November 22, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, November 16th 2020
This study conclusively demonstrates the long-speculated relationship between aging, gene regulation, and somatic damage. The results open up new avenues of research with practical implications. If the same level of coordination reduction between genes is indeed a leading cause for aging phenomena, there may be a need to change course in current efforts to develop aging treatments. Using Oligodendrocyte Extracellular Vesicles to Induce Tolerance to Myelin as a Treatment for Multiple Sclerosis https://www.fightaging.org/archives/2020/11/using-oligodendrocyte-extracellular-vesicles-to-induce-tolerance-to-myelin-a...
Source: Fight Aging! - November 15, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs