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Fight Aging! Newsletter, August 31st 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - August 30, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

A Two Part Interview with Greg Bailey of Juvenescence
Juvenescence and Life Biosciences are presently the two large business development companies in the growing longevity industry. They act much like venture funds, in that they create or take controlling positions in biotech startups, but are organized as companies in structure, with the ability to later go public. The resulting entity looks much like a Big Pharma company with many subsidiaries. It is quite possible to do this at a smaller scale and bootstrap towards much the same end goal - see Ichor Therapeutics and its portfolio companies, for example. Greg Bailey is one of the cofounders of Juvenescence, alongside...
Source: Fight Aging! - August 25, 2020 Category: Research Authors: Reason Tags: Investment Source Type: blogs

Podcast: Medical Model Errors and Omissions in Treating Mental Illness
  From lobotomies to pharmaceutical advertising to forced treatment, let’s discuss some of the more taboo topics in the history of psychiatry. While some of these approaches are obviously terrible (especially in hindsight) others are in the gray area. Should pharmaceutical companies be able to advertise directly to the patient? Is it OK to force psychiatric treatment in certain cases? What do you think? Tune in to today’s Not Crazy episode for a great discussion on the more controversial topics in the field of psychiatry. (Transcript Available Below) Please Subscribe to Our Show: And We Love Written Reviews! ...
Source: World of Psychology - August 18, 2020 Category: Psychiatry & Psychology Authors: Not Crazy Podcast Tags: General Not Crazy Podcast Psychiatry Treatment Source Type: blogs

Fight Aging! Newsletter, August 17th 2020
In this study, we sought to elucidate the role of VRK-1 in regulation of adult life span in C. elegans. We found that overexpression of VRK-1::GFP (green fluorescent protein), which was detected in the nuclei of cells in multiple somatic tissues, including the intestine, increased life span. Conversely, genetic inhibition of vrk-1 decreased life span. We further showed that vrk-1 was essential for the increased life span of mitochondrial respiratory mutants. We demonstrated that VRK-1 was responsible for increasing the level of active and phosphorylated form of AMPK, thus promoting longevity. A Fisetin Variant, C...
Source: Fight Aging! - August 16, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The Future Of Food And Eating
I do not have to stress how important a role food and eating play in our lives. Food is at the base in Maslow’s hierarchy of our needs; it is essential for our survival. It shows perfectly the creativity of humankind: food exists in the richest variety of ingredients, forms, shapes, tastes and colors all over the world from the Greenlandic kiviak (dozens of small birds stuffed into a seal fermented under a rock) through the Liquid Pea Sphere of molecular gastronomy to the tagliatelle with hand-cut meat ragout from the world’s best restaurant, Osteria Francescana. The advent of novel digital health tools will radicalise...
Source: The Medical Futurist - August 11, 2020 Category: Information Technology Authors: berci.mesko Tags: Future of Food 3d printing genomics Innovation technology GC1 sensors nutrigenomics food sensors Source Type: blogs

Redefining Values in American Health Care
By RICHARD HOEHN, MD Experts claim we could have been better prepared when the COVID-19 pandemic struck in early 2020. With an annual budget of $400-700 million, the Strategic National Stockpile (SNS) is designed to respond to chemical, biological, and other disasters. Its $8 billion inventory included 13,000 ventilators and a limited supply of personal protective equipment, N95 masks, and medical supplies. This left state and local governments scrambling as the COVID-19 pandemic accelerated and the capacity of many hospitals was overwhelmed. Faced with immediate and visible death and suffering, leaders took drastic...
Source: The Health Care Blog - August 6, 2020 Category: Consumer Health News Authors: Christina Liu Tags: Economics Health Policy Healthcare spending Richard Hoen Source Type: blogs

Fight Aging! Newsletter, August 3rd 2020
In this study, we examined the effects of oxytocin on the Aβ-induced impairment of synaptic plasticity in mice. To investigate the effect of oxytocin on synaptic plasticity, we prepared acute hippocampal slices for extracellular recording and assessed long-term potentiation (LTP) with perfusion of the Aβ active fragment (Aβ25-35) in the absence and presence of oxytocin. We found that oxytocin reversed the impairment of LTP induced by Aβ25-35 perfusion in the mouse hippocampus. These effects were blocked by pretreatment with the selective oxytocin receptor antagonist L-368,899. Furthermore, the treatment with the...
Source: Fight Aging! - August 2, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Podcast: Your Gut Instinct is Bad For Your Relationships
While caring for his wife as she struggled with a severe nervous breakdown, Dr. Gleb Tsipursky put the cognitive strategies he’d long been teaching others to work on his strained relationship. After seeing the incredible impact it had on his marriage as a whole, he decided to write a book to share these relationship-changing communication strategies. Join us as Dr. Tsipursky explains why going with your “gut” can actually backfire and shares 12 practical mental habits you can begin using today for excellent communication. We want to hear from you — Please fill out our listener survey by clicking the graphic a...
Source: World of Psychology - July 30, 2020 Category: Psychiatry & Psychology Authors: The Psych Central Podcast Tags: Communication General Habits Interview LifeHelper Marriage and Divorce Podcast Relationships The Psych Central Show Source Type: blogs

Tackling obesity: empowering adults and children to live healthier lives
Department of Health and Social Care - It has been known for decades that living with obesity reduces life expectancy and increases the chance of serious diseases such as cancer, heart disease and type 2 diabetes. In the last few months it has been seen that excess weight puts individuals at risk of worse outcomes from coronavirus (Covid-19). This policy paper outlines actions the government will take to tackle obesity and help adults and children to live healthier lives.Policy paperPress release 
Source: Health Management Specialist Library - July 26, 2020 Category: UK Health Authors: The King ' s Fund Library Tags: Local authorities, public health and health inequalities Source Type: blogs

Fight Aging! Newsletter, July 27th 2020
In this study, we applied a well studied prediction model developed on data from five CpG sites, to increase the practicability of these tests. We have determined the biological age of the heart, specifically of the right atrium (RA) and left atrium (LA), and of peripheral blood leucocytes, by measuring the mitotic telomere length (TL) and the non-mitotic epigenetic age (DNAmAge). We found that DNAmAge, of both atrial tissues (RA and LA), was younger in respect to the chronological age (-12 years). Furthermore, no significant difference existed between RA and LA, suggesting that, although anatomically diverse and ex...
Source: Fight Aging! - July 26, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The OneSkin Technologies DNA Methylation Clock for Assessment of Skin Aging
OneSkin Technologies is one of the first generation of startup biotech companies in the longevity industry; you'll find an overview of their programs and technology in an interview with founder Carolina Reis last year. In summary, OneSkin works on both improved models of aging skin, and topical senolytic compounds capable of selectively destroying the senescent cells thought to be responsible for a sizable fraction of skin aging in later life. Unlike other companies in the longevity industry, the OneSkin staff is focused on the cosmetics regulatory path to market. This is in some ways more limited, and in other ways much c...
Source: Fight Aging! - July 22, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Podcast: Life with Binge Eating Disorder
  At one point, Gabe weighed more than 550 pounds. Today, he and Lisa remember and discuss the extreme pain and slow healing process of living with binge-eating disorder. Gabe shares his shame in being so overweight, his intense relationship with food, the story of his gastric bypass and the difficult process of learning new coping mechanisms. How did Gabe’s bipolar and panic attacks tie in with his binge eating? And, importantly, how is he managing the illness today? Join us for an open and honest discussion on living with an eating disorder. (Transcript Available Below) Please Subscribe to Our Show: And We Lov...
Source: World of Psychology - July 21, 2020 Category: Psychiatry & Psychology Authors: Not Crazy Podcast Tags: Binge Eating Disorders Eating Disorders General Not Crazy Podcast Source Type: blogs

Fight Aging! Newsletter, July 20th 2020
This study was the first to demonstrate a causal relationship between glial senescence and neurodegeneration. In this study, accumulations of senescent astrocytes and microglia were found in tau-associated neurodegenerative disease model mice. Elimination of these senescent cells via a genetic approach can reduce tau deposition and prevent the degeneration of cortical and hippocampal neurons. Most recently, it was shown that clearance of senescent oligodendrocyte progenitor cells in AD model mice with senolytic agents could lessen the Aβ plaque load, reduce neuroinflammation, and ameliorate cognitive deficits. This...
Source: Fight Aging! - July 19, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, July 13th 2020
In conclusion, sitting for prolonged periods of time without interruption is unfavorably associated with DBP and HDL cholesterol. Exercise Slows Inappropriate Growth of Blood Vessels in a Mouse Model of Macular Degeneration https://www.fightaging.org/archives/2020/07/exercise-slows-inappropriate-growth-of-blood-vessels-in-a-mouse-model-of-macular-degeneration/ Excessive growth of blood vessels beneath the retina is a proximate cause of blindness in conditions such as macular degeneration. Researchers here provide evidence for physical activity to be influential in the pace at which this process of tissue...
Source: Fight Aging! - July 12, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, July 6th 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - July 5, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs