Filtered By:
Condition: Obesity

This page shows you your search results in order of date. This is page number 6.

Order by Relevance | Date

Total 911 results found since Jan 2013.

Fight Aging! Newsletter, August 22nd 2022
In conclusion, application of a multi-species bat epigenetic clock provides strong evidence that hibernation is associated with slower epigenetic ageing. The multi-species clock explains 94% of the variation in the chronological ages of both hibernating and non-hibernating big brown bats; however, the clock estimates are equal to or greater than the chronological age, suggesting big brown bats age slightly faster than a 'typical' bat, especially during the active period.
Source: Fight Aging! - August 21, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

How not go get cancer
The Global Burden of Disease project is a decades long international collaboration, based at the Institute for Health Metrics and Evaluation at the University of Washington, but involving researchers around the world. It was originally funded by the World Bank, and now receives its principal support from the Bill and Melinda Gates Foundation. GBD (not to be confused with golden brown and delicious) essentially tries to quantify the prevalence of diseases, and injuries around the world; the prevalence of associated disability; causes of death; and risk factors. They use a lot of complicated methods. If you ' re really ...
Source: Stayin' Alive - August 19, 2022 Category: American Health Source Type: blogs

Fight Aging! Newsletter, August 8th 2022
In conclusion, aging research will benefit from a better definition of how specific regulators map onto age-dependent change, considered on a phenotype-by-phenotype basis. Resolving some of these key questions will shed more light on how tractable (or intractable) the biology of aging is. Does Acarbose Extend Life in Short Lived Species via Gut Microbiome Changes? https://www.fightaging.org/archives/2022/08/does-acarbose-extend-life-in-short-lived-species-via-gut-microbiome-changes/ Acarbose is one of a few diabetes medications shown to modestly slow aging in short-lived species. Researchers here take a ...
Source: Fight Aging! - August 7, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Aging and the Severity of Inflammatory Infectious Disease Such as SARS-CoV-2
This article provides a pathophysiologic view of COVID-19 in older adults within the frame of inflammaging, with a focus on antiinflammatory treatments for acute and postacute disease. How can Biology of Aging Explain the Severity of COVID-19 in Older Adults Aging has been identified as one of the most relevant risk factors for poor outcomes in COVID-19 disease, independently from the presence of preexisting diseases. The COVID-19 mortality risk sharply increases for elderly subjects, as showed by the reports of China, Italy, and the United States. In particular, in Italy, case fatality rate for patient a...
Source: Fight Aging! - August 2, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Fight Aging! Newsletter, August 1st 2022
In this study, we used the recently released Infinium Mouse Methylation BeadChip to compare such epigenetic modifications in C57BL/6 (B6) and DBA/2J (DBA) mice. We observed marked differences in age-associated DNA methylation in these commonly used inbred mouse strains, indicating that epigenetic clocks for one strain cannot be simply applied to other strains without further verification. Interestingly, the CpGs with highest age-correlation were still overlapping in B6 and DBA mice and included the genes Hsf4, Prima1, Aspa, and Wnt3a. Furthermore, Hsf4, Aspa, and Wnt3a revealed highly significant age-associated DNA methyla...
Source: Fight Aging! - July 31, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Science Snippet: Lipids in the Limelight
This study could inform the advancement of new antibiotics.Developing new imaging technologies to track lipid droplet formation and breakdown in cancer cells. Understanding this phenomenon could shed light on why lipid droplets accumulate in these cells, which could aid in creating new therapies. Learn about other scientific terms with the NIGMS glossary.
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - July 27, 2022 Category: Research Authors: Chrissa Chverchko Tags: Cells Chemistry, Biochemistry and Pharmacology Cellular Processes COVID-19 Medicines Science-snippet Source Type: blogs

A gastric bypass might help some people bypass cancer
In an exciting recent study, researchers found that for adults with obesity, weight loss through bariatric surgery lowered their risk of cancer by 35% and reduced their risk of cancer-related death by 43%. This was true of both gastric bypass and gastric sleeve surgeries, and the results were observed ten years after patients’ procedures. This Read more… A gastric bypass might help some people bypass cancer originally appeared in KevinMD.com.
Source: Kevin, M.D. - Medical Weblog - July 23, 2022 Category: General Medicine Authors: Tags: Conditions Obesity Surgery Source Type: blogs

Fight Aging! Newsletter, July 18th 2022
In conclusion, we show that PVS morphology in mice is variable and that the structure and function of pia suggests a previously unrecognized role in regulating CSF transport and amyloid clearance in aging and disease. Reversing Ovarian Fibrosis in Mice https://www.fightaging.org/archives/2022/07/reversing-ovarian-fibrosis-in-mice/ Researchers here provide evidence for ovarian fibrosis to be an important mechanism in limiting the age at which female mammals can remain fertile. Interestingly, existing antifibrotic drugs can produce some reversal of this fibrosis, enough to restore ovulation in mice. Fibros...
Source: Fight Aging! - July 17, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Catching Up With ReMARCable Vanderbilt Graduates
Four of the first-cohort MARC scholars in April 2022. From left to right: Cassidy Johnson, Lucy Britto, Hannah Craft, and Sim Plotkin. Credit: Dr. Katherine Friedman. In 2021, we shared the perspectives of third-year undergraduates who had recently joined the first cohort of the Maximizing Access to Research Careers (MARC) program at Vanderbilt University in Nashville, Tennessee. Vanderbilt’s MARC program provides mentorship and professional development opportunities to third- and fourth-year undergraduates who plan to pursue advanced degrees and are from groups that are underrepresented in the biomedical sci...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - July 13, 2022 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Training Source Type: blogs

See what happens when the consultant is " Not convinced of STEMI "
 Sent by Arjun V, written by Pendell Meyers, edits by SmithA man in his early 40s with history of HTN and obesity suffered sudden out of hospital cardiac arrest. EMS arrived and found him in VF. He was defibrillated successfully, but had several more episodes of VF arrest on the way to the Emergency Department. Here are some examples of his prehospital rhythms:At the ED, sustained ROSC was achieved. He was intubated with minimal available neurologic exam.He had several ECGs recorded in the ED soon after ROSC:The ECGs show likelyAFib with RBBB morphology.  There isprofound right axis deviation, which likely r...
Source: Dr. Smith's ECG Blog - July 13, 2022 Category: Cardiology Authors: Pendell Source Type: blogs

Fight Aging! Newsletter, July 11th 2022
In this study we employ a transcriptome-wide and multi-tissue approach to analyze the influence of both LTDR and short-term DR (STDR) at old age on the aging phenotype. We were able to characterize a common transcriptional gene network driving inflammaging in most of the analyzed tissues. This network is characterized by chromatin opening and upregulation in the transcription of innate immune system receptors and by activation of interferon signaling through interferon regulatory factors, inflammatory cytokines, and Stat1-mediated transcription. We also found that both DR interventions ameliorate this inflammaging phenotyp...
Source: Fight Aging! - July 10, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

ALCAT1 in Age-Related Mitochondrial Dysfunction
One should always be somewhat dubious when researchers claim the primacy of any single mechanism in age-related dysfunction. It is one thing to demonstrate that a mechanism exists and is damaging, and quite another to show that it provides a significant contribution to aging in animal models or humans. Aging is enormously complex, and it has traditionally proven very challenging to repair or ameliorate just one mechanism in isolation, in order to see what happens. Bear this in mind while reading this otherwise interesting paper on the function of ALCAT1 in age-related mitochondrial dysfunction. Cardiolipin (CL) is...
Source: Fight Aging! - July 5, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Innate Immune Activation as a Contributing Cause of Inflammaging, Reduced by Calorie Restriction
In this study we employ a transcriptome-wide and multi-tissue approach to analyze the influence of both LTDR and short-term DR (STDR) at old age on the aging phenotype. We were able to characterize a common transcriptional gene network driving inflammaging in most of the analyzed tissues. This network is characterized by chromatin opening and upregulation in the transcription of innate immune system receptors and by activation of interferon signaling through interferon regulatory factors, inflammatory cytokines, and Stat1-mediated transcription. We also found that both DR interventions ameliorate this inflammaging phenotyp...
Source: Fight Aging! - July 4, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Cancer Survivors Exhibit a Significantly Higher Risk of Cardiovascular Disease
The dominant cancer therapies of chemotherapy and radiotherapy have not yet been replaced by immunotherapies for more than a handful of cancer types. These classes of therapy produce a significantly increased burden of senescent cells in patients; one of the goals of cancer therapy is to drive cancerous cells into senescence, those that cannot be killed. These additional senescent cells in turn accelerate the progression of degenerative aging. The advent of senolytic therapies to clear senescent cells from aged tissues will make a sizable difference to these patients. More effort should be undertaken today to enable patien...
Source: Fight Aging! - July 4, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Lifestyle Medicine Could Be The Key To Digital Health Adoption
I’ve been wearing several generations and types of smartwatches for a couple of years and I only remove my watch when I shower. I use it to track my sleep and its smart alarm wakes me up at the optimal time every morning. With the pocketable Kardia, I regularly check my ECG at home to detect any anomalies. For an in-depth analysis of what my genetic makeup predisposes me to, I had my whole genome sequenced. And I bring relevant data to my general practitioner during my checkups so that we can decide on preventive measures. In short, I’m trying to live like the patient of the future, using lifestyle medicine to prev...
Source: The Medical Futurist - June 29, 2022 Category: Information Technology Authors: Pranavsingh Dhunnoo Tags: Lifestyle medicine E-Patients Health Sensors & Trackers Healthcare Design Medical Education Personalized Medicine sleep stress food scanner sleep apnea Apple Watch Dr. Vernes Baylor ACLM Source Type: blogs