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Fight Aging! Newsletter, February 28th 2022
In conclusion, as BMI and waist circumference are related to elevations of immune markers in the IL-6 pathway, chronic inflammation might be an important mediator of the relationship between BMI and frailty.
Fat Tissue Becomes Dysfunctional with Age as Mitochondria Falter
https://www.fightaging.org/archives/2022/02/fat-tissue-becomes-dysfunctional-with-age-as-mitochondria-falter/
Mitochondria are effectively power plants, hundreds of them working in every cell to produce chemical energy store molecules to power cellular processes. Mitochondrial function declines with age, unfortunately, for underlying re...
Source: Fight Aging! - February 27, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, February 21st 2022
In conclusion, clinical trials targeting aging in humans have shown promising but limited results on biomarkers so far.
Mycobacterium Vaccae Immunization as an Anti-Inflammatory Strategy
https://www.fightaging.org/archives/2022/02/mycobacterium-vaccae-immunization-as-an-anti-inflammatory-strategy/
In today's open access paper, researchers discuss immunization with Mycobacterium vaccae as an approach to reduce the inflammatory overactivity of the aged immune system. Researchers have made some initial inroads into studying the way in which this bacteria can alter the function of the immune system, and here...
Source: Fight Aging! - February 20, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Rationing and Indication
I ' ll let y ' all in on a secret: I ' m writing a book. It ' s basically everything you need to know, as a citizen, taxpayer, consumer of medical services, friend or family member of consumers of medical services, and just plain person, about health and health care in the U.S. For some reason I haven ' t much connected the work on the book to this blog -- there is tons of materials I could have lifted from my book chapters and posted here for your delectation and delight. I ' m not sure why I haven ' t been doing that, and maybe I will.Anyway, the previous post creates an occasion to discuss a matter that seems pretty obv...
Source: Stayin' Alive - January 31, 2022 Category: American Health Source Type: blogs
Fight Aging! Newsletter, January 31st 2022
In conclusion, the effects of MR on the gut barrier were likely related to alleviation of the oscillations of inflammation-related microbes. MR can enable nutritional intervention against age-related gut barrier dysfunction.
Clearing Senescent Cells from the Neural Stem Cell Niche Rapidly Improves Neurogenesis in Old Mice
https://www.fightaging.org/archives/2022/01/clearing-senescent-cells-from-the-neural-stem-cell-niche-rapidly-improves-neurogenesis-in-old-mice/
Neurogenesis is the generation of new neurons in the brain, and their integration into existing neural circuits. It is essential to learning an...
Source: Fight Aging! - January 30, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, January 17th 2022
In conclusion, fibroblasts in monolayers cultured with soluble pentosidine and tridimensional in vitro skin constructs exposed to the combination of AGEs and UVA promote an inflammatory state and an alteration of the dermal compartment in relation to an elastosis-like environment.
Source: Fight Aging! - January 16, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Join Dr. Davis ’ Infinite Health Boot Camp January 5th to the 14th
Undoctored is now Dr. Davis Infinite Health (www.DrDavisInfiniteHealth that goes live in early January) as its name suggests, puts personal control over health back in your hands. We continue many of the strategies of the Wheat Belly lifestyle but expand them with lessons learned through this worldwide experience, while adding new dimensions and practices. While we make the transition to Dr. Davis Infinite Health and away from Undoctored, the concepts and practices remain the same.
The Dr. Davis’ Wild, Naked, and Unwashed program causes you to revert back to the way humans were supposed to be eating and living all ...
Source: Wheat Belly Blog - December 22, 2021 Category: Cardiology Authors: April Duval Tags: Open Undoctored Source Type: blogs
Join the Undoctored Boot Camp January 5th to the 14th
Undoctored, as its name suggests, puts personal control over health back in your hands. We continue many of the strategies of the Wheat Belly lifestyle but expand them with lessons learned through this worldwide experience, while adding new dimensions and practices.
The Undoctored Wild, Naked, and Unwashed program causes you to revert back to the way humans were supposed to be eating and living all along to mimic the behavior and health of primitive people who have virtually no modern diseases such as diabetes, colon cancer, and obesity (still lived to old age if they did not succumb to injury or infection). Learn:
How...
Source: Wheat Belly Blog - December 22, 2021 Category: Cardiology Authors: April Duval Tags: Open Undoctored Source Type: blogs
Fight Aging! Newsletter, December 13th 2021
In conclusion, there is a good amount of pre-clinical and clinical data showing a strong positive correlation between reduction of senescent cells frequencies and functional improvement of skin. Whether senescence of skin cells makes a significant causal contribution to skin ageing can still not be conclusively decided, however. Nonetheless, there is strong evidence existing today to assume that better understanding of cell senescence in skin may lead to a breakthrough in interventions into skin ageing.
Isomerization of Tau May be Involved in Alzheimer's Disease
https://www.fightaging.org/archives/2021/12/isome...
Source: Fight Aging! - December 12, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Exercise Slows Retinal Aging, but Which of the Many Mechanisms Involved are Important?
As researchers note here, there is evidence for exercise to slow retinal aging and the progression of conditions involving retinal degeneration. Exercise affects many aspects of aging, not to the same degree as the practice of calorie restriction, but likely through an overlapping set of mechanisms related to cellular stress response upregulation, including increased autophagy and mitochondrial quality control. There is is a vast forest of interacting metabolic changes to explore, however, and the research community has yet to come to a solid grasp of which of the effects of exercise are the most relevant in any given tiss...
Source: Fight Aging! - December 10, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, December 6th 2021
In this study, they found these drugs can kill senescent cells from cultures of human fat tissue. The tissue was donated by individuals with obesity who were known to have metabolic troubles. Without treatment, the human fat tissues induced metabolic problems in immune-deficient mice. After treatment with dasatinib and quercetin, the harmful effects of the fat tissue were almost eliminated.
Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity
Insulin resistance is a pathological state often associated with obesity, representing a major risk factor for type 2...
Source: Fight Aging! - December 5, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, November 29th 2021
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - November 28, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Is Anatomy Finished? | A Review of New Discoveries | TAPP 105
Are there reallyno more discoveries in human anatomy? In this episode, I'll review some recent discoveries: the rise of thefabella, macrophage barriers, the interstitium, button and zipper junctions, lymph node micro-organs, new vessels in bones, andtubarial salivary glands.00:00 | Introduction00:41 | Is Anatomy Finished?03:44 | Sponsored by AAA04:16 | Rise of the Fabella11:52 | Sponsored by HAPI12:38 | Macrophage Barriers23:18 | Sponsored by HAPS23:55 | Interstitium27:48 | Button and Zipper Junctions35:28 | Lymphatic Micro-Organ40:05 | Free Update Newsletter41:05 | New Vessels in Bones44:44 | Tubarial Salivary Glands...
Source: The A and P Professor - November 16, 2021 Category: Physiology Authors: Kevin Patton Source Type: blogs
Fight Aging! Newsletter, November 15th 2021
This article will review the relationship between diabetes mellitus and AD as it relates to tau pathology. More understanding of the link between diabetes mellitus and AD could change the approach researchers and clinicians take toward both diseases, potentially leading to new treatments and preventative strategies in the future.
Signaling from White Fat Tissue Contributes to Age-Related Hair Follicle Dysfunction
https://www.fightaging.org/archives/2021/11/signaling-from-white-fat-tissue-contributes-to-age-related-hair-follicle-dysfunction/
Changes in fat tissue behavior in the skin take place with age, ...
Source: Fight Aging! - November 14, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
More Data to Suggest that Moderate Alcohol Consumption Confers No Benefits
The objective was to analyze former alcohol or drug use disorders, risky drinking, tobacco smoking, and fair to poor health among persons who reported abstinence from alcohol drinking in the last 12 months before baseline in relation to total, cardiovascular, and cancer mortality 20 years later. A sample of residents aged 18 to 64 years had been drawn at random among the general population in northern Germany and a standardized interview conducted in the years 1996 to 1997. The baseline assessment included 4,093 persons (70.2% of those who had been eligible). Vital status and death certificate data were retrieved in the ye...
Source: Fight Aging! - November 11, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
The Tumor Suppression Theory of Aging
While they cannot explain aging as a whole, single cause theories of aging can be useful tools to frame discussion and investigation aimed at better understanding aging and its evolution. The theory presented here is aging viewed through the lens of cancer, two entwined processes. Aging is viewed as largely a consequence of tumor suppression mechanisms that evolved to keep cancer at a low enough incidence for successful selection and continuation of the species. Cancer and evolution are themselves in a dynamic, competing equilibrium. Evolution requires a certain minimal rate of spontaneous mutation, while cancer thrives on...
Source: Fight Aging! - November 4, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
