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Clearance of Senescent Cells Reverses the Peripheral Neuropathy Caused by Chemotherapy
A primary goal of chemotherapy is to force cancerous cells into programmed cell death or cellular senescence. Cellular senescence is a state of growth arrest that should normally be triggered by exactly the sort of damage and dysfunction exhibited by cancer cells, but cancer is characterized by a mutation-induced ability to bypass those restrictions. Chemotherapy remains the primary approach to cancer therapy, but chemotherapeutic agents are still at best only marginally discriminating. Treating cancer with chemotherapy has always been a fine balance between harming the cancer and harming the patient. Even in the best of o...
Source: Fight Aging! - September 14, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Fight Aging! Newsletter, September 14th 2020
This study is the first to provide a direct link between this inflammation and plaque development - by way of IFITM3. Scientists know that the production of IFITM3 starts in response to activation of the immune system by invading viruses and bacteria. These observations, combined with the new findings that IFITM3 directly contributes to plaque formation, suggest that viral and bacterial infections could increase the risk of Alzheimer's disease development. Indeed, researchers found that the level of IFITM3 in human brain samples correlated with levels of certain viral infections as well as with gamma-secretase activ...
Source: Fight Aging! - September 13, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

A Meta-Analysis of the Ability of Exercise to Reduce Age-Related Mortality
The objective of this study was to conduct a systematic review and dose-response meta-analysis of physical activity and mortality in people with selected non-communicable diseases (NCDs). We aimed to define the dose-response relationship between post-diagnosis physical activity and mortality rates for nine NCDs with a high global burden of disease, including low back pain, type 2 diabetes (T2D), osteoarthritis, depressive disorder, chronic obstructive pulmonary disease (COPD), breast cancer, lung cancer, stroke, and ischemic heart disease (IHD). In total, 28 studies were included in the meta-analysis: 12 for breast ...
Source: Fight Aging! - September 10, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, August 31st 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - August 30, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, August 24th 2020
We report that electrical stimulation (ES) stimulation of post-stroke aged rats led to an improved functional recovery of spatial long-term memory (T-maze), but not on the rotating pole or the inclined plane, both tests requiring complex sensorimotor skills. Surprisingly, ES had a detrimental effect on the asymmetric sensorimotor deficit. Histologically, there was a robust increase in the number of doublecortin-positive cells in the dentate gyrus and SVZ of the infarcted hemisphere and the presence of a considerable number of neurons expressing tubulin beta III in the infarcted area. Among the genes that were unique...
Source: Fight Aging! - August 23, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Podcast: Medical Model Errors and Omissions in Treating Mental Illness
  From lobotomies to pharmaceutical advertising to forced treatment, let’s discuss some of the more taboo topics in the history of psychiatry. While some of these approaches are obviously terrible (especially in hindsight) others are in the gray area. Should pharmaceutical companies be able to advertise directly to the patient? Is it OK to force psychiatric treatment in certain cases? What do you think? Tune in to today’s Not Crazy episode for a great discussion on the more controversial topics in the field of psychiatry. (Transcript Available Below) Please Subscribe to Our Show: And We Love Written Reviews! ...
Source: World of Psychology - August 18, 2020 Category: Psychiatry & Psychology Authors: Not Crazy Podcast Tags: General Not Crazy Podcast Psychiatry Treatment Source Type: blogs

Suicide After Suicide: What We Must Do to Break the Cycle
Each day, from every corner of the world, people left in the devastating aftermath of suicide call out to other survivors of such loss wherever they gather. It is helpful to connect with people who have experienced similar tragedies and are trying to make sense of what happened to their lives. Another, more painful reason they seek comfort from strangers is this: in the case of suicide, those who knew them best often withdraw or are unable to help because of misunderstanding and fear. Most do survive and go on to rebuild, but some experience multiple suicides and a few follow loved ones by ending their own lives. As a sur...
Source: World of Psychology - August 16, 2020 Category: Psychiatry & Psychology Authors: Jan McDaniel Tags: Depression Grief and Loss Suicide Suicide contagion suicide loss survivor Survivor Guilt Source Type: blogs

How to Get Into Star Trek
This article idea was suggested by a Conscious Growth Club member. After a little reflection, I thought, why not? I’ve seen every episode of every non-animated Star Trek series, including the original 1960s classic, The Next Generation, Deep Space Nine, Voyager, Enterprise, Discovery, and the new Picard series. I’ve seen many episodes multiple times. I’ve seen all of the movies. I’ve been to a Star Trek Convention in Las Vegas. So I’m pretty well versed in Star Trek lore. I met William Shatner (aka Captain Kirk) very briefly when I was in my 20s because we had the same lawyer for a while...
Source: Steve Pavlina's Personal Development Blog - August 13, 2020 Category: Psychiatry & Psychology Authors: Steve Pavlina Tags: Lifestyle Values Source Type: blogs

Redefining Values in American Health Care
By RICHARD HOEHN, MD Experts claim we could have been better prepared when the COVID-19 pandemic struck in early 2020. With an annual budget of $400-700 million, the Strategic National Stockpile (SNS) is designed to respond to chemical, biological, and other disasters. Its $8 billion inventory included 13,000 ventilators and a limited supply of personal protective equipment, N95 masks, and medical supplies. This left state and local governments scrambling as the COVID-19 pandemic accelerated and the capacity of many hospitals was overwhelmed. Faced with immediate and visible death and suffering, leaders took drastic...
Source: The Health Care Blog - August 6, 2020 Category: Consumer Health News Authors: Christina Liu Tags: Economics Health Policy Healthcare spending Richard Hoen Source Type: blogs

4 Examples Of Merging Gaming & Digital Health
Pausing to check his map, Sam confirms that he is on the right track for his next delivery, only 2 kilometres left. He takes the opportunity to quench his thirst and check if his delivery load is securely attached to his back; some contain fragile vials of medicines and digital pills susceptible to damage if handled inappropriately. After making sure of the integrity of those packages, Sam takes a final look at his surroundings. “It’s quite peaceful with nobody around,” he thinks to himself and resumes his path.  Upon arrival at his destination, his gear is disinfected before he has access to the inte...
Source: The Medical Futurist - August 4, 2020 Category: Information Technology Authors: Prans Tags: Artificial Intelligence Augmented Reality Digital Health Research Healthcare Design Healthcare Policy Telemedicine & Smartphones Virtual Reality fda gamification Fitbit covid19 Apple Watch WHO gaming roche MySugr Foldit A Source Type: blogs

Podcast: My Husband Has Psychosis
  What does psychosis feel like? What’s the difference between a delusion that demons exist and a religious belief of the same? In today’s show, Gabe and Lisa recall Gabe’s real-life psychotic episodes and discuss all the pain and stress surrounding psychosis. Join us as Gabe shares how it felt when there were demons under his bed and when the window washers were watching his every move. (Transcript Available Below) Please Subscribe to Our Show: And We Love Written Reviews!  About The Not Crazy podcast Hosts Gabe Howard is an award-winning writer and speaker who lives with bipolar disorder. He is the auth...
Source: World of Psychology - August 4, 2020 Category: Psychiatry & Psychology Authors: Not Crazy Podcast Tags: Bipolar General Not Crazy Podcast Schizophrenia Source Type: blogs

Seven evidence-based reasons to start meditating yesterday
Yes, starting today is OK too. I started meditating soon after 9/11. I was living in Manhattan, an already chaotic place, at an extremely chaotic time. I realized I had no control over my external environment. But the one place I did have a say over was my mind, through meditation. When I started meditating, I did not realize it would also make me healthier, happier, and more resilient. Having witnessed the benefits, I devoted my PhD research at Stanford to studying the impact of meditation. I saw people from diverse backgrounds from college students to combat veterans benefit. In the last 10 years, hundreds of studies hav...
Source: SharpBrains - August 3, 2020 Category: Neuroscience Authors: Emma Seppala, PhD Tags: Cognitive Neuroscience Education & Lifelong Learning Health & Wellness brain emotion regulation happiness meditation mental hygiene mind productivity self-control Source Type: blogs

When the World Is Breaking Your Heart
The other week, my husband and I were driving home after visiting a beloved family member who is struggling with the excruciating pain and to-the-bone weariness of cancer. As our car lugged down the highway, I thought about the ongoing cruelty of our world: the ravages of disease and war, the current pandemic, the never-ending inhumanity, inequality, and brutality, as well as the general disregard to our earth and the innocent creatures who are clinging to survive on it. (And, yes, I do realize that I’m just as guilty as the masses in spewing out pollution by the simple fact that I drive a car). I held back tears, and th...
Source: World of Psychology - August 2, 2020 Category: Psychiatry & Psychology Authors: Tracy Shawn, MA Tags: Death & Dying Depression Grief and Loss Inspiration & Hope Personal Cancer Optimism Source Type: blogs

Fight Aging! Newsletter, August 3rd 2020
In this study, we examined the effects of oxytocin on the Aβ-induced impairment of synaptic plasticity in mice. To investigate the effect of oxytocin on synaptic plasticity, we prepared acute hippocampal slices for extracellular recording and assessed long-term potentiation (LTP) with perfusion of the Aβ active fragment (Aβ25-35) in the absence and presence of oxytocin. We found that oxytocin reversed the impairment of LTP induced by Aβ25-35 perfusion in the mouse hippocampus. These effects were blocked by pretreatment with the selective oxytocin receptor antagonist L-368,899. Furthermore, the treatment with the...
Source: Fight Aging! - August 2, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

My Journey from Fear to Love
"Everything will be okay in the end. If it's not okay, it's not the end." – John Lennon January - 2012 I remember sitting in a small dark room waiting for the surgeon to arrive. My son had just had major surgery, and it had taken much longer than expected. My stomach felt tense as the surgeon sat in the chair opposite us. He looks at the floor as he started to speak. "it's not good news," he said. "We think he has a week left to live." After that, my mind switched off. I felt my wife's head on my shoulder and heard her tears. Was it a bad dream? June – 2017 My feet feel heavy as I am ne...
Source: PickTheBrain | Motivation and Self Improvement - July 30, 2020 Category: Consumer Health News Authors: Thomas Westenholz Tags: creativity family featured happiness relationships self-improvement fear love self improvement Source Type: blogs