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Is the blood pressure same on both arms? Cardiology Basics
Guidelines on hypertension by medical societies generally recommend measurement of blood pressure in both arms in the initial visit. They also suggest that the arm with higher blood pressure recording should be used to record blood pressure in subsequent visits. It is often mentioned that there is a small difference in the blood pressure between the arms and usually it is the right arm blood pressure which is higher. The origin of brachiocephalic artery is in line with the ascending aorta. It is presumed that the force of ejection of the left ventricle is conveyed more to the right subclavian artery for this reason. When ...
Source: Cardiophile MD - October 6, 2022 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs

How is thyroid linked to heart disease? Cardiology Basics
Disorders of thyroid gland can cause heart disease in multiple ways. Heart disease can occur with both hypothyroidism and hyperthyroidism. In hyperthyroidism, heart rate increases and there is a hyperdynamic circulatory state which can lead to high output cardiac failure. Unlike in the usual congestive heart failure in which the extremities are cold due to vasoconstriction, in heart failure due to hyperthyroidism, the extremities are warm. Instead of a low volume pulse in usual heart failure, thyrotoxic heart failure has a high volume pulse. Another important cardiac problem in hyperthyroidism is atrial fibrillation with ...
Source: Cardiophile MD - October 5, 2022 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs

PROTECTED TAVR – Cerebral embolic protection?
PROTECTED TAVR – Cerebral embolic protection? Higher rates of stroke have been considered as a limitation of transcatheter aortic valve replacement (TAVR) in comparison with surgical aortic valve replacement (SAVR) [1,2]. Stroke following TAVR has been shown to increase the 30 day mortality from 3.7% to 16.7% according to a retrospective report from Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapies Registry. The registry had 101 430 patients who were treated with femoral and non-femoral TAVR at 521 US hospitals between 2011 and 2017 [3]. A previous study had used cerebral embol...
Source: Cardiophile MD - October 5, 2022 Category: Cardiology Authors: Johnson Francis Tags: Angiography and Interventions General Cardiology Structural Heart Disease Interventions Source Type: blogs

Coffee good for heart health – Large study
Coffee good for heart health – Large study Usually physicians, including me, ask patients with cardiovascular disease to avoid coffee, especially for those with cardiac arrhythmia [1]. Now, here is a study which says that taking 2-3 cups of decaffeinated, ground or instant coffee a day is associated with significant reductions in incident cardiovascular disease and mortality. Even more, ground and instant coffee, but not decaffeinated coffee was associated with reduced arrhythmia [2]. In fact, coffee consumption at 3-4 cups per day has been described as probably not harmful and perhaps even moderately beneficial in t...
Source: Cardiophile MD - September 30, 2022 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs

Contrasting results of REDUCE-IT and STRENGTH trials of Omega 3
Contrasting results of REDUCE-IT [1] and STRENGTH [2] trials of Omega 3 fatty acid preparations have caught the attention of scientific community. Icosapent ethyl, a highly purified eicosapentaenoic acid ethyl ester was evaluated in REDUCE-IT (Reduction of Cardiovascular Events With Icosapent Ethyl-Intervention Trial). In STRENGTH trial carboxylic acid formulation of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) were used. REDUCE-IT was a multicenter, randomized, double blind, placebo controlled trial. Patients enrolled had established cardiovascular disease or diabetes with other risk factors. They were rece...
Source: Cardiophile MD - September 27, 2022 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs

hs-CRP as a risk assessment tool for cardiovascular disease
It is often mentioned that almost half of first cardiovascular events occur in individuals with no known risk factors. C-reactive protein (CRP) which is usually considered as an inflammatory marker, has emerged as an important cardiovascular risk marker as well. CRP is equivalent to LDL cholesterol (low density lipoprotein cholesterol) as a risk marker. Being an inflammatory marker, high CRP levels also indicate the possibility of plaque rupture leading to coronary thrombosis and myocardial infarction [1]. The current high sensitivity assays of CRP known in short as hs-CRP can also predict recurrent coronary events in tho...
Source: Cardiophile MD - September 25, 2022 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs

Finerenone, a non-steroidal MRA
Finerenone is a nonsteroidal, selective mineralocorticoid receptor antagonist. Finerenone is thought to have lower risk of hyperkalemia and renal issues compared to other MRAs. It has been shown to reduce albuminuria in patients with chronic kidney disease and type 2 diabetes mellitus. FInerenone in reducing kiDnEy faiLure and dIsease prOgression in Diabetic Kidney Disease (FIDELIO-DKD) study evaluated the renal and cardiovascular outcomes in patients with CKD and type 2 diabetes mellitus. 5734 patients with CKD and type 2 diabetes were randomized to finerenone or placebo. All patients were on renin-angiotensin system blo...
Source: Cardiophile MD - September 24, 2022 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs

Spontaneous coronary artery dissection (SCAD)
Spontaneous coronary artery dissection (SCAD) is an important, though rare cause of acute coronary syndrome. Management of SCAD is different from that of acute coronary syndrome due to atherosclerosis [1]. High index of suspicion is required for the diagnosis of SCAD in young patients with acute coronary syndrome. Unlike atherosclerotic coronary artery disease, management of SCAD is mostly medical, in stable patients. Revascularization is considered only in high risk patients with left main dissection, ongoing ischemia, severely limited flow, hemodynamic compromise or refractory cardiac arrhythmia [2]. It has been mentio...
Source: Cardiophile MD - September 23, 2022 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs

5 Scenarios Of How Your Health Data Can Be (Or Was Already) Stolen
I really don’t want to sound like Aunt Karen, suspecting a culprit hiding behind every bush, but chances are your health data was or will be stolen. This is a strong statement and might sound paranoid. But, as the old joke goes: being paranoid doesn’t mean someone is not after you.  Here we will introduce five general scenarios of how unknown third-party actors can access your health data without your knowledge (and consent). We introduce these to paint a clearer picture of how medical data can change hands and help you prepare to avoid it – as much as possible. You had a genetic test done You o...
Source: The Medical Futurist - September 15, 2022 Category: Information Technology Authors: Andrea Koncz Tags: TMF Forecast Artificial Intelligence in Medicine Digital Health Research Future of Food Healthcare Policy Security & Privacy Source Type: blogs

Vitamin K antagonist superior to DOAC in RHD with AF – INVICTUS study
Vitamin K antagonist superior to DOAC in RHD with AF – INVICTUS study The INVICTUS program (INVestIgation of rheumatiC AF Treatment Using VKA) was designed as an open label parallel group trial comparing treatment with vitamin K antagonists or rivaroxaban, in rheumatic heart disease with atrial fibrillation [1]. It was an international multicentre randomized study. A registry of 17,000 patients was also planned to document the contemporary clinical course of patients with RHD, including a focused sub-study on pregnant women with RHD within the registry. RHD is considered as a neglected disease affecting 33 million pe...
Source: Cardiophile MD - September 10, 2022 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs

Weekly Overseas Health IT Links –10th September, 2022.
This article is adapted fromVoices in the Code: A Story About People, Their Values, and the Algorithm They Made,out Sept. 8 from Russell Sage Foundation Press.In May 2021, I got a call I never expected. I was working on abook about A.I. ethics, focused on the algorithm that gives out kidneys to transplant patients in the United States. Darren Stewart —a data scientist from UNOS, the nonprofit that runs the kidney allocation process—was calling to get my take: How many decimal places should they include when calculating each patient’s allocation score? The score is an incredibly important number, given it determines w...
Source: Australian Health Information Technology - September 10, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs

Weekly Overseas Health IT Links –27th August 2022.
In this study, researchers gathered a diverse group of participants; 43 percent were Black, and 68 percent were women. They also considered factors such as age and insurance status when drawing conclusions.The study occurred through a clinical trial, where all participants were randomly assigned to have their next visit occur through either phone or video-based platforms. The central unit of measurement was visit satisfaction rate, reported on a ten-point scale. Researchers noted noninferiority data based on whether patient satisfaction between the telehealth methods exceeded a -15 percent margin.-----https://www.theverge....
Source: Australian Health Information Technology - August 27, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs

Pharmacists Can Now Prescribe Paxlovid. Good idea?
BY ANISH KOKA Apparently, the US Food and Drug Administration (FDA), that has long been charged with the safety and efficacy of drugs and devices now also controls who can prescribe drugs. I was under the mistaken impression that in our highly rule based society you would need to pass a law to allow that to happen. Passing laws , of course, can be a long, messy, process that involves having to convince constituencies, and ruling by executive order is just way more efficient apparently. So by decree of the FDA patients can now get Paxlovid, an anti-viral for the virus that causes COVID19, “directly from...
Source: The Health Care Blog - August 22, 2022 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Medical Practice Physicians Primary Care COVID-19 FDA Paxlovid Source Type: blogs

Fight Aging! Newsletter, June 20th 2022
This study showed a negative relationship between the gaps and the number of senescence cells. Moreover, we found a similar reduction in 30-month-old naturally and 7-month-old D-gal-induced aging rats. Given these consistent data from different eukaryotic organisms, it suggests that the Youth-DNA-GAP is a marker of phenotype-related aging degree Towards Scaffold-Based Regeneration of Dental Pulp https://www.fightaging.org/archives/2022/06/towards-scaffold-based-regeneration-of-dental-pulp/ Researchers are working towards the ability to regenerate the dental pulp inside teeth. Full regeneration of teeth h...
Source: Fight Aging! - June 19, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Inflammaging as a Contributing Factor in the Development of Cardiovascular Disease
Inflammaging is the name given to the decline of the aging immune system into a state of constant, unresolved inflammation. Inflammatory signaling in the aged body arises in part because of an increased burden of senescent cells. These cells secrete a potent mix of pro-inflammatory signals, disrupting tissue function. This is one of the reasons why removal of lingering senescent cells produces such rapid rejuvenation, as these errant cells actively maintain a portion of the degradation of function and environment in aged tissues. Beyond senescent cells, the broad molecular damage and cellular dysfunction of aging produces ...
Source: Fight Aging! - June 15, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs