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Wait, Other People Don ’ t Think about Suicide?
The most startling thing I’ve heard in my life is that not everyone thinks about suicide every day. Or now and then. Or even once in a long while. Can that be? I heard this from a co-worker a while ago. We were collaborating on a dreary project, and I joked about it being the kind of work that makes you want to kill yourself and what a relief that would be. “I know, right?” I expected her to say. Instead, she chuckled uncomfortably, then asked if I really thought that way. When I said yes, she was taken aback and a little disbelieving. “You never have?” I asked. “Of course not!” I was taken aback. And a littl...
Source: World of Psychology - April 28, 2020 Category: Psychiatry & Psychology Authors: Rich Pliskin Tags: Personal Suicide Depression Suicidal Thoughts Source Type: blogs

Fight Aging! Newsletter, April 27th 2020
In conclusion, our study demonstrated that Nrf2 deficiency promoted the increasing trend of autophagy during aging in skeletal muscle. Nrf2 deficiency and increasing age may cause excessive autophagy in skeletal muscle, which can be a potential mechanism for the development of sarcopenia. To What Degree is Chondrocyte Hypertrophy in Osteoarthritis Due to Cellular Senescence? https://www.fightaging.org/archives/2020/04/to-what-degree-is-chondrocyte-hypertrophy-in-osteoarthritis-due-to-cellular-senescence/ Senescent cells are large. They do not replicate, that function is disabled, but it is as if they go ...
Source: Fight Aging! - April 26, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, April 20th 2020
In conclusion, elevated brain amyloid was associated with family history and APOE ε4 allele but not with multiple other previously reported risk factors for AD. Elevated amyloid was associated with lower test performance results and increased reports of subtle recent declines in daily cognitive function. These results support the hypothesis that elevated amyloid represents an early stage in the Alzheimer's continuum. Blood Metabolites as a Marker of Frailty https://www.fightaging.org/archives/2020/04/blood-metabolites-as-a-marker-of-frailty/ Frailty in older people is usually diagnosed in a symptomatic ...
Source: Fight Aging! - April 19, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The American Society for Reproductive Medicine Covid-19 Guidelines: In Favor of Delaying Most Infertility Treatments without Devaluing Them
In response to the global Covid-19 pandemic, the American Society for Reproductive Medicine (ASRM) created a specific task force to address infertility treatments, which were only indirectly mentioned in other Covid-19 guidelines. Their guidelines generated some controversy, as evidenced by a change.org petition that as of this writing, has over 13,300 signatures opposing ASRM’s recommendations to “[s]uspend initiation of new treatment cycles,” “[s]trongly consider cancellation of all embryo transfers,” and “[s]uspend elective surgeries and non-urgent diagnostic procedures.” More i...
Source: blog.bioethics.net - April 13, 2020 Category: Medical Ethics Authors: Bioethics Today Tags: Health Care Author: Campo-Engelstein Fertility reproductive medicine reproductive rights syndicated Women's Reproductive Rights Source Type: blogs

Patients & Vulnerable Populations Pandemically Left in the Dark
By GRACE CORDOVANO PhD, BCPA To be honest, the United States blew it on the mask front. From a public health, caregiver and patient safety, as well as community transmission standpoint, we are at least 3 months late to game. Anytime a brand new virus that humanity does not have any immunity to makes an appearance, is highly contagious, starts rapidly infecting people as well as the doctors and nurses caring for them, hospitalizing, and killing them in concerning numbers across the globe, we should enable every proactive safety measure at our disposal. The first confirmed case of COVID-19 in the US was on January 20,...
Source: The Health Care Blog - April 7, 2020 Category: Consumer Health News Authors: Christina Liu Tags: COVID-19 Health Policy coronavirus Grace Cordovano masks Pandemic Source Type: blogs

‘Sophie’s Choice’ in the time of coronavirus: Deciding who gets the ventilator
Three otherwise healthy patients go to the emergency department with severe acute respiratory failure. Only one ventilator, required to sustain life until the worst of the coronavirus infection has passed, is available. Who gets the vent? That’s what “A Framework for Rationing Ventilators and Critical Care Beds During the COVID-19 Pandemic,” a Viewpoint just published in the Journal of the American Medical Association (JAMA), addresses. Douglas White, MD, MAS, Endowed Chair for Ethics in Critical Care Medicine at the University of Pittsburgh School of Medicine ...
Source: blog.bioethics.net - April 6, 2020 Category: Medical Ethics Authors: Bioethics Today Tags: Health Care Author: Lewis syndicated Source Type: blogs

Fight Aging! Newsletter, March 30th 2020
This study, for the first time, shows that transplantation of non-autologous mitochondria from healthy skeletal muscle cells into normal cardiomyocytes leads to short-term improvement of bioenergetics indicating "supercharged" state. However, over time these improved effects disappear, which suggests transplantation of mitochondria may have a potential application in settings where there is an acute stress. Outlining Some of the Science Behind Partial Reprogramming at Turn.bio https://www.fightaging.org/archives/2020/03/outlining-some-of-the-science-behind-partial-reprogramming-at-turn-bio/ Turn.bio is a...
Source: Fight Aging! - March 29, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The role of our minds in the avoidance of falls
A few years ago, my grandmother suffered a fall and broke her hip. She has never fully recovered and is now constantly fearful of falling, and has significantly limited her activities to prevent a fall from ever happening again. As a scientist focused on translational research in mobility and falls in older adults, of course I asked her how she fell. She stated that she was standing in the kitchen and reading a recipe when the phone rang. When she turned and started to walk over to the phone, her feet “weren’t in the right spot.” She fell sideways and unfortunately, her hip was unable to absorb the impact without bre...
Source: Harvard Health Blog - February 28, 2020 Category: Consumer Health News Authors: Brad Manor, PhD Tags: Bones and joints Caregiving Healthy Aging Neurological conditions Source Type: blogs

Five healthy habits net more healthy years
Are healthy habits worth cultivating? A recent study suggests healthy habits may help people tack on years of life and sidestep serious illnesses, such as diabetes and cancer. After all, if you’re going to gain an extra decade of life on this earth, you want to enjoy it! What did this research focus on? Researchers from the Harvard T.H. Chan School of Public Health looked at data from more than 73,000 women enrolled in the Nurses’ Health Study (NHS) who were followed for 34 years, and more than 38,000 men enrolled in the Health Professionals Follow-up Study (HPFS) who were followed for 28 years. In a previous study usi...
Source: Harvard Health Blog - February 19, 2020 Category: Consumer Health News Authors: Monique Tello, MD, MPH Tags: Exercise and Fitness Health Healthy Aging Healthy Eating Men's Health Women's Health Source Type: blogs

Fight Aging! Newsletter, February 10th 2020
In conclusion, the concept of an epigenetic clock is compelling, but caution should be taken in interpreting associations with age acceleration. Association tests of age acceleration should include age as a covariate. A Discussion of Recent Work on Allotopic Expression of Mitochondrial Genes at the SENS Research Foundation https://www.fightaging.org/archives/2020/02/a-discussion-of-recent-work-on-allotopic-expression-of-mitochondrial-genes-at-the-sens-research-foundation/ A paper published last month outlines recent progress on allotopic expression of mitochondrial genes carried out by the SENS Research ...
Source: Fight Aging! - February 9, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Chronic Inflammation is of Great Importance in the Progression of Aging
We describe the multi-level mechanisms underlying SCI and several risk factors that promote this health-damaging phenotype, including infections, physical inactivity, poor diet, environmental and industrial toxicants, and psychological stress. Furthermore, we suggest potential strategies for advancing the early diagnosis, prevention and treatment of SCI.
Source: Fight Aging! - February 4, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Fight Aging! Newsletter, January 27th 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - January 26, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

A Letter to Ms. Judy Faulkner & Mr. Tommy Thompson
By GRACE CORDOVANO PhD, BCPA Being a patient or a carepartner can be a lonely, powerless place. There’s no high powered legal or lobbying team to help support you in your or your loved one’s health care journey. There’s no PR team at your beck and call. There’s no advisory board, no executive committee, no assistants, no chatbots or AI-powered technology coming to the rescue. There’s no funding or a company sponsoring your efforts. There’s no course in how to be a professional patient or carepartner. There’s no one there in the stillness and dark of the night, when you are in the quiet of your tho...
Source: The Health Care Blog - January 24, 2020 Category: Consumer Health News Authors: Christina Liu Tags: Health Policy Patients caregivers carepartner Grace Cordovano Judy Faulkner patient advocacy Patient advocates Tommy Thompson Source Type: blogs

Misunderstandings of Mental Illness Cost Qualified People Their Jobs
Complaining about work is a popular pastime. It can be a way of bonding with others who also have impossible bosses, annoying coworkers, or miserable working conditions. But few of us would want to be unfairly barred from all that work can offer. The benefits of a job go beyond economic support. In the best cases, jobs can provide structure, social ties and social support, welcome challenges, and maybe even a sense of self and a meaningful life. If you have a mental illness, though, you may find it particularly difficult to land a job, even if you want to work and you are qualified for the jobs that interest you. According...
Source: World of Psychology - January 22, 2020 Category: Psychiatry & Psychology Authors: Bella DePaulo, Ph.D. Tags: Policy and Advocacy Stigma Mental Illness Stigma Source Type: blogs

Notes on the SENS Research Foundation Pitch Day, January 2020
The J.P. Morgan Healthcare conference runs every year in San Francisco, a big draw for the biotech industry, and many organizations take the opportunity to host events at the same time. Among these, the SENS Research Foundation has for the past few years hosted a pitch day in which biotech companies in the longevity industry, largely startups, present to that portion of the Bay Area investor community interested in funding the treatment of aging as a medical condition. I was there to present on progress at Repair Biotechnologies, and took some notes on the other companies as they talked about their work. Kimera Labs ...
Source: Fight Aging! - January 20, 2020 Category: Research Authors: Reason Tags: Investment Source Type: blogs